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Nitrite protects rat lung grafts from ischemia/reperfusion injury via nitric oxide 査読

Ryujiro Sugimoto, Atsunori Nakao, Junichi Kohmoto, Yinna Wang, Mark T. Gladwin, Timothy R. Billiar, Kenneth R. McCurry

AMERICAN JOURNAL OF TRANSPLANTATION 8 498 - 498 2008年5月

Hydrogen inhalation ameliorates cold ischemia/reperfusion injury of rat cardiac grafts 査読

Atsunori Nakao, David J. Kaczorowski, Ryujiro Sugimoto, Yinna Wang, Timothy R. Billiar, Kenneth R. McCurry

AMERICAN JOURNAL OF TRANSPLANTATION 8 501 - 501 2008年5月

Application of heme oxygenase-1, carbon monoxide and biliverdin for the prevention of intestinal ischemia/reperfusion injury. 査読

Atsunori Nakao, David J Kaczorowski, Ryujiro Sugimoto, Timothy R Billiar, Kenneth R McCurry

Journal of clinical biochemistry and nutrition 42 ( 2 ) 78 - 88 2008年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION

Intestinal ischemia/reperfusion (I/R) injury occurs frequently in a variety of clinical settings, including mesenteric artery occlusion, abdominal aneurism surgery, trauma, shock, and small intestinal transplantation, and is associated with substantial morbidity and mortality. Although the exact mechanisms involved in the pathogenesis of intestinal I/R injury have not been fully elucidated, it is generally believed that polymorphonuclear neutrophils, pro-inflammatory cytokines, and mediators generated in the setting of oxidative stress, such as reactive oxygen species (ROS), play important roles. Heme oxygenase (HO) is the rate-limiting enzyme that catalyzes the degradation of heme into equimolar quantities of biliverdin and carbon monoxide (CO), while the central iron is released. An inducible form of HO (HO-1), biliverdin, and CO, have been shown to possess generalized endogenous anti-inflammatory activities and provide protection against intestinal I/R injury. Further, recent observations have demonstrated that exogenous HO-1 expression, as well as exogenously administered CO and biliverdin, have potent cytoprotective effects on intestinal I/R injury as well. Here, we summarize the currently available data regarding the role of the HO system in the prevention intestinal I/R injury.

DOI： 10.3164/jcbn.2008013

Web of Science

PubMed

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Reduction of cerebral infarction in rats by biliverdin associated with amelioration of oxidative stress 査読国際誌

Kentaro Deguchi, Takeshi Hayashi, Shoko Nagotani, Yoshihide Sehara, Han Zhe Zhang, Atsushi Tsuchiya, Yasuyuki Ohta, Koji Tomiyama, Nobutoshi Morimoto, Masahiro Miyazaki, Nam ho Huh, Atsunori Nakao, Tatsushi Kamiya, Koji Abe

Brain Research 1188 ( 1 ) 1 - 8 2008年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER

Biliverdin (BV), one of the byproducts of heme catalysis through heme oxygenase (HO) system, is a scavenger of reactive oxygen species (ROS). We hypothesized that BV treatment could protect rat brain cells from oxidative injuries via its anti-oxidant efficacies. Cerebral infarction was induced by transient middle cerebral artery occlusion (tMCAO) for 90 min, followed by reperfusion. BV or vehicle was administered intraperitoneally immediately after reperfusion. The size of the cerebral infarction 2 days after tMCAO was evaluated by 2,3,5-triphenyltetrazolium chloride (TTC) stain. Superoxide generation 4 h after tMCAO was determined by detection of oxidized hydroethidine. In addition, the oxidative impairment of neurons were immunohistochemically assessed by stain for lipid peroxidation with 4-hydroxy-2-nonenal (4-HNE) and damaged DNA with 8-hydroxy-2′-deoxyguanosine (8-OHdG). BV treatment significantly reduced infarct volume of the cerebral cortices associated with less superoxide production and decreased oxidative injuries of brain cells. The present study demonstrated that treatment with BV ameliorated the oxidative injuries on neurons and decreased brain infarct size in rat tMCAO model. © 2007 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.brainres.2007.07.104

Toll-like receptor 4 mediates the early inflammatory response after cold ischemia/reperfusion. 査読国際誌

David J Kaczorowski, Atsunori Nakao, Kevin P Mollen, Raghuveer Vallabhaneni, Ryujiro Sugimoto, Junichi Kohmoto, Kimimasa Tobita, Brian S Zuckerbraun, Kenneth R McCurry, Noriko Murase, Timothy R Billiar

Transplantation 84 ( 10 ) 1279 - 87 2007年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS

BACKGROUND: Ischemia/reperfusion (I/R) injury leads to graft dysfunction and may contribute to alloimmune responses posttransplantation. The molecular mechanisms of cold I/R injury are only partially characterized but may involve toll-like receptor (TLR)-4 activation by endogenous ligands. We tested the hypothesis that TLR4 mediates the early inflammatory response in the setting of cold I/R in a murine cardiac transplant model. METHODS: Syngeneic heart transplants were performed in mutant mice deficient in TLR4 signaling (C3H/HeJ) and wild-type mice (C3H/HeOuJ). Transplants were also performed between the strains (mutant hearts into wild-type recipients and the converse). Donor hearts were subjected to 2 hr of cold ischemia. The grafts were retrieved at 3 and 24 hr after reperfusion. Serum samples were collected for cytokine analysis. Reverse-transcription polymerase chain reaction and histologic analysis were used to assess intra-graft inflammation. RESULTS: After transplant, serum tumor necrosis factor (TNF), interleukin (IL)-6, JE/monocyte chemotractant protein (MCP)-1, IL-1beta, and troponin I levels, as well as intragraft TNF, IL-1beta, IL-6, early growth response (EGR)-1, intercellular adhesion molecule (ICAM)-1, and inducible nitric oxide synthase (iNOS) mRNA levels, were significantly lower in the mutant-->mutant group compared to the wild-type-->wild-type group (P< or =0.05). Intermediate levels of serum IL-6, JE/MCP-1, as well as intragraft TNF, IL-1beta, IL-6, and ICAM-1 mRNA were observed after transplants in the mutant-->wild-type and wild-type-->mutant groups. Immunohistochemistry revealed less myocardial nuclear factor-kappaB nuclear translocation at and less neutrophil infiltration in the mutant-->mutant group compared to the wild-type-->wild-type group. CONCLUSIONS: These findings demonstrate that TLR4 signaling is central to both the systemic and intragraft inflammatory responses that occur after cold I/R in the setting of organ transplantation and that TLR4 signaling on both donor and recipient cells contributes to this response.

DOI： 10.1097/01.tp.0000287597.87571.17

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Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. 国際誌

The Journal of experimental medicine 203 ( 10 ) 2377 - 89 2006年10月

Heart allograft protection with low-dose carbon monoxide inhalation: effects on inflammatory mediators and alloreactive T-cell responses. 査読国際誌

Atsunori Nakao, Hideyoshi Toyokawa, Masanori Abe, Tetsuma Kiyomoto, Kiichi Nakahira, Augustine M K Choi, Michael A Nalesnik, Angus W Thomson, Noriko Murase

Transplantation 81 ( 2 ) 220 - 30 2006年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Carbon monoxide (CO), a byproduct of heme catalysis, has lately received considerable attention as a regulatory molecule in cellular and biological processes. CO has been shown to provide potent protection against a variety of tissue injuries. We hypothesized in this study that low concentration CO would be beneficial for organ allografts, which frequently undergo several types of injury such as ischemia/reperfusion, alloimmune reaction, and inflammation METHODS: The efficacy of low-dose CO was examined in a fully allogeneic LEW to BN rat heterotopic heart transplantation (HHTx) model. Recipients were kept in air or exposed to low-dose CO (20 ppm) for 14, 28, or 100 days after HHTx under short-course tacrolimus RESULTS: CO treatment (d0-28, 0-100) was remarkably effective in prolonging heart allograft survival to a median of >100 from 45 days in the air-control group, with significant reductions of arteritis, fibrosis, and cellular infiltration, including macrophages and T cells. CO inhibited intragraft upregulation of Th1 type cytokines (IL-2, IFNgamma), proinflammatory mediators (IL-1beta, TNFalpha, IL-6, COX-2), and adhesion molecule. Shorter CO exposure in early (0-13d) and late (14-28d) posttransplant periods also prolonged graft survival, with a significant inhibition of inflammatory mediators CONCLUSIONS: These results show that low dose CO inhalation protects heart allografts and can considerably prolong their survival. CO appears to function via multiple mechanisms, including direct inhibition of Th1 type cytokine production and regulation of inflammatory responses.

DOI： 10.1097/01.tp.0000188637.80695.7f

PubMed

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Multiple hepatic adenomas caused by long-term administration of androgenic steroids for aplastic anemia in association with familial adenomatous polyposis.

NAKAO Atsunori, SAKAGAMI Kenichi, NAKATA Yusei, KOMAZAWA Katsutaka, AMIMOTO Tatsuya, NAKASHIMA Koichiro, ISOZAKI Hiroshi, TAKAKURA Norihisa, TANAKA Noriaki

Journal of gastroenterology 35 ( 7 ) 557 - 562 2000年7月

Generalized peritonitis due to spontaneously perforated pyometra presenting as pneumoperitoneum: report of a case.

NAKAO ATSUNORI, MIMURA HISASHI, FUJISAWA KENJI, EZAWA KAZUHIKO, OKAMOTO TAKAHIRO, IWAGAKI HIROMI, ISOZAKI HIROSHI, TAKAKURA NORIHISA, TANAKA NORIAKI

Surgery today 30 ( 5 ) 454 - 457 2000年5月

Gastric perforation caused by a bulimic attack in an anorexia nervosa patient: report of a case.

NAKAO ATSUNORI, ISOZAKI HIROSHI, IWAGAKI HIROMI, KANAGAWA TAIICHIRO, TAKAKURA NORIHISA, TANAKA NORIAKI

Surgery today 30 ( 5 ) 435 - 437 2000年5月

Gallbladder torsion: case report and review of 245 cases reported in the Japanese literature

NAKAO A

Journal of Hepato-Biliary-Pancreatic Surgery 6 418 - 421 1999年12月

Portal venous gas associated with splenic abscess secondary to colon cancer.

NAKAO A

Anticancer research 19 5641 - 5644 1999年12月

Dermoid cyst of the spleen: Report of a case

NAKAO Atsunori, SAITO Shinya, YAMANO Taketoshi, TAKAKURA Norihisa, ISOZAKI Hiroshi, NOTOHARA Kenji, TANAKA Noriaki

Surgery Today 29 ( 7 ) 660 - 662 1999年7月

Gastric carcinoma with predominant choriocarcinomatous component

NAKAO Atsunori, SAKAGAMI Kenichi, UDA Masashi, MITSUOKA Shintaro, YAMASHITA Naoto, ITO Hisao

International Journal of Clinical Oncology 3 ( 6 ) 403 - 405 1998年12月

Benign fibrous mesothelioma successfully treated by thoracoscope-Assisted surgery: Report of a case

NAKAO ATSUNORI, SAKAGAMI KENICHI, UDA MASASHI, MITSUOKA SHINTARO, ITO HISAO

Surgery Today 28 ( 10 ) 1087 - 1090 1998年10月

所属リンパ節にサルコイド反応がみられた胆管癌の1症例

中尾篤典

胆と膵 17 963 - 966 1996年12月

Bobbin threaderを用いた骨弁形成術の新しい工夫

中尾篤典, 広畑泰三, 大林直彦

脳神経外科ジャーナル 5 ( 6 ) 470 - 471 1996年11月

担当区分：筆頭著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本脳神経外科コングレス

骨弁形成の際,ドリルで開けた小孔に遊離骨弁を固定するための糸を通すが,その操作は意外に煩雑さを感じることがある.われわれはBobbin Threader^[○!R]を用いて,硬膜を損傷する危険がなく,安全で容易な閉頭術を行っている.Bobbin Threader[○!R]の臨床使用経験と有用性を報告する.

CiNii Article

CiNii Books

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粘膜内癌を伴った巨大な直腸villous tumorの1例??10cm以上の大腸villous tumor本邦報告15例の検討

中尾篤典

広島医学 49 970 - 972 1996年7月

抗血小板療法中に起きた大腿神経麻痺を伴う腸腰筋血腫の1例

中尾篤典

外科診療 6 745 - 747 1996年6月

肝癌術後の肺転移に対し, Epirubicinの少量頻回投与が有効であった2症例

中尾篤典

癌と化学療法 22 1831 - 1834 1995年10月

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