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SCN5A遺伝子のスプライシングドナーサイトに新規のmutationを認めたBrugada症候群の1例

三浦大志, 中村一文, 三浦綾, 平松茂樹, 渡邊敦之, 西井伸洋, 伴場主一, 谷山真規子, 木村英夫, 岩崎淳, 浦川茂美, 角田和歌子, 湯本晃久, 河野康之, 永瀬聡, 櫻木悟, 草野研吾, 大江透

心電図 26 ( 4 ) 500 - 500 2006年6月

イオンチャネル異常による致死性不整脈 Brugada症候群におけるSCN5A遺伝子変異の臨床的意義

伴場主一, 永瀬聡, 三浦大志, 平松茂樹, 西井伸洋, 渡辺敦之, 中村一文, 櫻木悟, 酒井芳昭, 草野研吾, 大江透

心電図 26 ( 4 ) 408 - 408 2006年6月

Andersen症候群の母子における各種薬剤負荷による心電図学的検討

永瀬聡, 西井伸洋, 伴場主一, 渡辺敦之, 平松茂樹, 酒井芳昭, 三浦大志, 三浦綾, 中村一文, 桜木悟, 草野研吾, 大江透

心電図 26 ( 4 ) 485 - 485 2006年6月

SCN5A遺伝子のスプライシングドナーサイトに新規のmutationを認めたBrugada症候群の1例

Journal of Arrhythmia 22 ( Suppl. ) 244 - 244 2006年5月

イオンチャネル異常による致死性不整脈 Brugada症候群におけるSCN5A遺伝子変異の臨床的意義

伴場主一, 永瀬聡, 三浦大志, 平松茂樹, 西井伸洋, 渡辺敦之, 中村一文, 桜木悟, 酒井芳昭, 草野研吾, 大江透

Journal of Arrhythmia 22 ( Suppl. ) 152 - 152 2006年5月

Andersen症候群の母子における各種薬剤負荷による心電図学的検討

永瀬聡, 西井伸洋, 伴場主一, 渡辺敦之, 平松茂樹, 酒井芳昭, 三浦大志, 三浦綾, 中村一文, 桜木悟, 草野研吾, 大江透

Journal of Arrhythmia 22 ( Suppl. ) 229 - 229 2006年5月

[Long QT syndrome].

Atsuyuki Watanabe, Kazufumi Nakamura, Hiroshi Morita, Kengo Fukushima Kusano, Tohru Ohe

Nihon rinsho. Japanese journal of clinical medicine 63 ( 7 ) 1171 - 7 2005年7月

記述言語：日本語掲載種別：研究論文（学術雑誌）

The long QT syndrome (LQTS) is characterized by prolongation of the QT interval, causing torsade de pointes and sudden cardiac death. This syndrome can be divided into idiopathic (congenital) and acquired forms. The idiopathic form is a familial disorder that can be associated with sensorineural deafness (Jervell and Lange--Nielsen syndrome, autosomal recessive) or normal hearing (Romano--Ward syndrome, autosomal dominant). The acquired form has a long QT interval caused by various drugs such as quinidine sotalol and dofetilide, also by noncardiovascular drugs such as antihistamine, antibiotics, antipsychotics and others. Also, the QT interval is prolonged by electrolyte abnormalities such as hypokalemia and hypomagnesemia, central nervous system lesions, significant bradyarrhythmias, cardiac ganglionitis, mitral valve prolapse and probucol. DNA variants appearing to predispose to drug-associated acquired long QT syndrome have been reported in congenital long QT.

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カルシウム拮抗薬(CCB)の抗炎症作用についての検討

三浦龍志, 中村一文, 三浦大志, 三浦綾, 久松研一, 橋本克史, 永瀬聡, 森田宏, 草野研吾, 齋藤博則, 江森哲郎, 大江透

Circulation Journal 69 ( Suppl.II ) 805 - 805 2005年4月

SCN5A遺伝子異常(R282H)を認めたBrugada症候群の一家系

中村一文, 三浦大志, 平松茂樹, 湯本晃久, 江森哲郎, 森田宏, 渡辺敦之, 永瀬聡, 齋藤博則, 草野研吾, 西井伸洋, 大江透, 長野仁, 神山憲王

Circulation Journal 69 ( Suppl.II ) 798 - 798 2005年4月

心室細動に対してキニジンが奏功したBrugada症候群の1例

渡辺敦之, 森田宏, 角田和歌子, 伴場主一, 西井伸洋, 永瀬聡, 中村一文, 齋藤博則, 草野研吾, 江森哲郎, 大江透

Circulation Journal 69 ( Suppl.II ) 797 - 797 2005年4月

Relationships between depolarization abnormality and repolarization abnormality in patients with Brugada syndrome: using body surface signal-averaged electrocardiography and body surface maps. 国際誌

Kenichi Hisamatsu, Kengo Fukushima Kusano, Hiroshi Morita, Shiho Takenaka, Satoshi Nagase, Kazufumi Nakamura, Tetsuro Emori, Hiromi Matsubara, Hiroshi Mikouchi, Yoshitomo Nishizaki, Tohru Ohe

Journal of cardiovascular electrophysiology 15 ( 8 ) 870 - 6 2004年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

INTRODUCTION: Repolarization and depolarization abnormalities have been reported to be related to Brugada syndrome. METHODS AND RESULTS: We evaluated the relationships between repolarization abnormality and depolarization abnormality using 48-lead unipolar signal-averaged electrocardiograms and 87-lead unipolar body surface maps in 15 patients with Brugada-type ECGs. Data were compared with those from healthy control subjects (n = 5) and within subgroups of Brugada syndrome with (n = 8) and without (n = 7) ventricular arrhythmias (VA) induced by programmed electrical stimulation (PES). Eighty-seven-lead body surface maps were recorded, and potential maps were constructed to evaluate elevation of the ST segment 20 ms after the J point. Forty-eight-lead signal-averaged ECGs were recorded, and isochronal maps of duration of the delayed potential (dDP) were constructed to evaluate the dDP in each lead. Potential maps showed that patients with Brugada-type ECG, especially those with VA induced by programmed electrical stimulation, had greater elevation of the ST segment in the right ventricular outflow tract, especially at E5. Isochronal maps of dDP in the Brugada-type ECG group showed that maximum dDP was located at E5 and that the area with long dDP was larger than that in the control subjects. The dDPs at E7, E5, F7, and F5 in the VA-inducible group were significantly longer than those in the VA-noninducible group. These results showed that the location of greater elevation in the ST segment coincided with the location of longer dDP. CONCLUSION: Repolarization abnormality and depolarization abnormality in the walls of both ventricles, especially in the right ventricular outflow tract, are related to the VA of Brugada syndrome.

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不整脈治療とその効果 QOLと予後の改善をめざして Brugada症候群に対する植込み型除細動器による治療予後とQOLの観点からの検討

江森哲郎, 森田宏, 永瀬聡, 西井伸洋, 伴場主一, 渡辺敦之, 中村一文, 斉藤博則, 草野研吾, 大江透

Journal of Cardiology 44 ( Suppl.I ) 194 - 194 2004年8月

Brugada症候群患者でのイソプレナリンの治療効果

渡辺敦之, 森田宏, 西井伸洋, 伴場主一, 永瀬聡, 中村一文, 斎藤博則, 草野研吾, 江森哲郎, 大江透

心電図 24 ( 5 ) 345 - 345 2004年8月

非虚血性心筋症患者の生命予後と心室頻拍に対する治療戦略について

西井伸洋, 江森哲郎, 宮地克維, 永瀬聡, 中村一文, 森田宏, 斎藤博則, 草野研吾, 大江透

心電図 24 ( 5 ) 382 - 382 2004年8月

不整脈治療とその効果 QOLと予後の改善をめざして Brugada症候群に対する植込み型除細動器による治療予後とQOLの観点からの検討

江森哲郎, 森田宏, 永瀬聡, 西井伸洋, 伴場主一, 渡辺敦之, 中村一文, 斉藤博則, 草野研吾, 大江透

心電図 24 ( 5 ) 293 - 293 2004年8月

Evaluation of the usefulness of recording the ECG in the 3rd intercostal space and prevalence of Brugada-type ECG in accordance with recently established electrocardiographic criteria.

Kenichi Hisamatsu, Hiroshi Morita, Kengo Fukushima Kusano, Shiho Takenaka, Satoshi Nagase, Kazufumi Nakamura, Tetsuro Emori, Tohru Ohe

Circulation journal : official journal of the Japanese Circulation Society 68 ( 2 ) 135 - 8 2004年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: It has been reported that recording electrocardiograms (ECGs) in the 3rd intercostal space (ICS) is one method that can be used for detecting Brugada syndrome; however, the prevalence of Brugada-type ECGs recorded in the 3rd ICS and the usefulness of recording the ECG in the 3rd ICS in accordance with recently established electrocardiographic criteria is unknown. METHODS AND RESULTS: ECGs were recorded in both the 4th and 3rd ICS in 17 Brugada-type ECG patients (group A) and in 206 consecutive male subjects (group B). Brugada-type ECGs were divided into 3 types. In group A, the prevalence of type 1 ECG, which is a coved-type ECG with ST-segment elevation of >/=2 mm, increased from 23.5% to 64.7% when ECG was recorded in the 3rd ICS. The conversion to type 1 ECG was found to be related to induction of ventricular arrhythmia. In group B, the prevalence of Brugada-type ECG increased from 1.5% to 5.8% when the ECG was recorded in the 3rd ICS. CONCLUSIONS: Recording the ECG in the 3rd ICS is useful for identifying high-risk patients with Brugada-type ECG and for detecting concealed Brugada-type ECG.

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Risk stratification for asymptomatic patients with Brugada syndrome.

Hiroshi Morita, Shiho Takenaka-Morita, Kengo Fukushima-Kusano, Makoto Kobayashi, Satoshi Nagase, Mikio Kakishita, Kazufumi Nakamura, Tetsuro Emori, Hiromi Matsubara, Tohru Ohe

Circulation journal : official journal of the Japanese Circulation Society 67 ( 4 ) 312 - 6 2003年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

Ventricular fibrillation (VF) is induced in some asymptomatic patients with Brugada syndrome (BS), but the prognostic value of programmed electrical stimulation (PES) in such patients is controversial. The clinical characteristics of 41 asymptomatic BS patients, divided into 2 groups according to whether VF was induced by PES (inducible VF group: n=13, non-inducible VF group: n=28) were evaluated. ST levels in the right precordial leads were measured before and after administration of pilsicainide and the abnormal late potential (LP) was evaluated on the signal-averaged electrogram. The ST level at V(2) at baseline in the inducible VF group was significantly higher than that in the non-inducible VF group (p<0.05). Pilsicainide induced significant ST segment elevation in both groups and the ST level after pilsicainide in the inducible VF group was higher than that in the non-inducible VF group (p<0.01). LP was more frequent in the inducible VF group than in the non-inducible VF group. The criterion of ST level >0.15 mV at baseline with pilsicainide-induced additional ST elevation >0.10 mV and positive LP showed high sensitivity (92%) and specificity (89%) for detection of PES-induced VF in asymptomatic BS patients.

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原発性肺高血圧症における右室心筋内微小血管の検討二次性肺高血圧症と比較して

大田恵子, 中村陽一, 草野研吾, 永瀬聡, 中村一文, 森田宏, 江森哲朗, 松原広己, 大江透

血栓と循環 10 ( 1 ) 85 - 85 2002年3月

原発性肺高血圧症における右室心筋内微小血管の検討二次性肺高血圧症と比較して

大田恵子, 中村陽一, 草野研吾, 永瀬聡, 中村一文, 森田宏, 江森哲朗, 松原広己, 大江透

循環器科 51 ( 2 ) 192 - 192 2002年2月

原発性肺高血圧症における右室心筋内微小血管の組織学的検討

大田恵子, 草野研吾, 永瀬聡, 宮地克維, 中村一文, 森田宏, 江森哲郎, 松原広己, 大江透, 中村陽一

Japanese Circulation Journal 65 ( Suppl.III ) 798 - 798 2001年10月

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