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論文 - 竹内　栄

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Neuromedin U Deficiency Disrupts Daily Testosterone Fluctuation and Reduces Wheel-running Activity in Rats 査読国際共著国際誌

Mai Otsuka, Yu Takeuchi, Maho Moriyama, Sakura Egoshi, Yuki Goto, Tingting Gu, Atsushi P Kimura, Shogo Haraguchi, Taishi Yoshii, Sakae Takeuchi, Makoto Matsuyama, George E Bentley, Sayaka Aizawa

Endocrinology 2025年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：The Endocrine Society

Abstract

The objective of this study was to elucidate the role of endogenous Neuromedin U (NMU) in rats by performing NMU knockout (KO). Male, but not female NMU KO rats exhibited decreased wheel-running activity versus wild-type (WT), although overall home cage activity was not affected. Plasma testosterone in WT rats varied significantly over the course of a day, with a peak at ZT1 and a nadir at ZT18, whereas in NMU KO rats testosterone remained stable throughout the day. Chronic administration of testosterone restored wheel-running activity in NMU KO rats to the same level as in WT rats, suggesting that the decrease in wheel-running activity in NMU KO rats is due to the disruption of the diurnal change of testosterone. Accordingly, expression of the luteinizing hormone beta subunit (Lhb) mRNA in the pars distalis of anterior pituitary was significantly lower in NMU KO rats; immunostaining revealed that the size of LH-expressing cells also was relatively small in those animals. In the brain of male WT rats, Nmu was highly expressed in the pars tuberalis and NMU receptor Nmur2 was highly expressed in the ependymal cell layer of the third ventricle. This study reveals a novel function of NMU and indicates that endogenous NMU in rats plays a role in the regulation of motivated activity via regulation of testosterone.

DOI： 10.1210/endocr/bqaf102

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Identification of pennaceous barbule cell factor (PBCF), a novel gene with spatiotemporal expression in barbule cells during feather development 査読国際誌

Minori Nakaoka, Hibiki Fukuchi, Maho Ogoshi, Sayaka Aizawa, Sakae Takeuchi

Gene 941 149244 - 149244 2025年3月

Crosstalk between prolactin, insulin-like growth factors, and thyroid hormones in feather growth regulation in neonatal chick wings, 査読国際誌

Yuri Nozawa, Ayako Okamura, Hibiki Fukuchi, Masamichi Shinohara, Sayaka Aizawa, Sakae Takeuchi

General and Comparative Endocrinology, 2024, 114657, ISSN 0016-6480 2024年12月

Revisiting the hormonal control of sexual dimorphism in chicken feathers 査読国際誌

Li You, Kaori Nishio, Kinue Kowata, Minaru Horikawa, Hibiki Fukuchi, Maho Ogoshi, Sayaka Aizawa, Sakae Takeuchi

General and Comparative Endocrinology 357 114601 - 114601 2024年10月

A regulatory mechanism of mouse kallikrein 1 gene expression by estrogen 査読国際誌

Takumi Iwasaki, Megumi Tokumori, Misaki Matsubara, Fumiya Ojima, Kana Kamigochi, Sayaka Aizawa, Maho Ogoshi, Atsushi P. Kimura, Sakae Takeuchi, Sumio Takahashi

Molecular and Cellular Endocrinology 577 112044 - 112044 2023年11月

Neuromedin U-deficient rats do not lose body weight or food intake 査読国際誌

Kyoka Yokogi, Yuki Goto, Mai Otsuka, Fumiya Ojima, Tomoe Kobayashi, Yukina Tsuchiba, Yu Takeuchi, Masumi Namba, Mayumi Kohno, Minami Tetsuka, Sakae Takeuchi, Makoto Matsuyama, Sayaka Aizawa

Scientific Reports 12 ( 1 ) 17472 - 17472 2022年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

Abstract

Studies in genetically modified mice establish that essential roles of endogenous neuromedin U (NMU) are anorexigenic function and metabolic regulation, indicating that NMU is expected to be a potential target for anti-obesity agents. However, in central administration experiments in rats, inconsistent results have been obtained, and the essential role of NMU energy metabolism in rats remain unclear. This study aims to elucidate the role of endogenous NMU in rats. We generated NMU knockout (KO) rats that unexpectedly showed no difference in body weight, adiposity, circulating metabolic markers, body temperature, locomotor activity, and food consumption in both normal and high fat chow feeding. Furthermore, unlike reported in mice, expressions of Nmu and NMU receptor type 2 (Nmur2) mRNA were hardly detectable in the rat hypothalamic nuclei regulating feeding and energy metabolism, including the arcuate nucleus and paraventricular nucleus, while Nmu was expressed in pars tuberalis and Nmur2 was expressed in the ependymal cell layer of the third ventricle. These results indicate that the species–specific expression pattern of Nmu and Nmur2 may allow NMU to have distinct functions across species, and that endogenous NMU does not function as an anorexigenic hormone in rats.

DOI： 10.1038/s41598-022-21764-6

PubMed

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その他リンク： https://www.nature.com/articles/s41598-022-21764-6

Adrenomedullin 2 and 5 activate the calcitonin receptor-like receptor (clr) – Receptor activity-modifying protein 3 (ramp3) receptor complex in Xenopus tropicalis 査読国際誌

Maho Ogoshi, Mikoto Takahashi, Kota Aoyagi, Kazuyoshi Ukena, Sayaka Aizawa, Hideaki Takeuchi, Sumio Takahashi, Sakae Takeuchi

General and Comparative Endocrinology 306 113752 - 113752 2021年5月

Discovery of a new nucleotide substitution in the MC1R gene and haplotype distribution in native and non-Japanese chicken breeds 査読

M. H. Kabir, A. Takenouchi, M. I. Haqani, Y. Nakamura, S. Takeuchi, M. Tsudzuki

Animal Genetics 51 ( 2 ) 235 - 248 2020年3月

Adenosine stimulates neuromedin U mRNA expression in the rat pars tuberalis. 査読

Sayaka Aizawa, Tingting Gu, Arisa Kaminoda, Ryuya Fujioka, Fumiya Ojima, Ichiro Sakata, Takafumi Sakai, Maho Ogoshi, Sumio Takahashi, Sakae Takeuchi

Molecular and cellular endocrinology 1 ( 496 ) 2019年10月

Runx3 regulates folliculogenesis and steroidogenesis in granulosa cells of immature mice. 査読

Fumiya Ojima, Yuka Saito, Yukiko Tsuchiya, Maho Ogoshi, Hiroshi Fukamachi, Kenichi Inagaki, Fumio Otsuka, Sakae Takeuchi, Sumio Takahashi

Cell and tissue research 375 ( 3 ) 743 - 754 2019年3月

Changes in prolactin receptor homodimer availability may cause late feathering in chickens 査読

Ayako Okamura, Ayane Masumoto, Atsushi Takenouchi, Toshiyuki Kudo, Sayaka Aizawa, Maho Ogoshi, Sumio Takahashi, Masaoki Tsudzuki, Sakae Takeuchi

General and Comparative Endocrinology 272 109 - 116 2019年2月

Runx3 transcription factor regulates ovarian functions and ovulation in female mice 査読

Fumiya Ojima, Yuka Saito, Yukiko Tsuchiya, Daichi Kayo, Syusuke Taniuchi, Maho Ogoshi, Hiroshi Fukamachi, Sakae Takeuchi, Sumio Takahashi

JOURNAL OF REPRODUCTION AND DEVELOPMENT 62 ( 5 ) 479 - 486 2016年10月

Functional characterization of the mouse melanocortin 3 receptor gene promoter. 査読国際誌

Okutsu K, Ojima F, Shinohara N, Taniuchi S, Mizote Y, Aoki K, Kudo T, Ogoshi M, Takeuchi S, Takahashi S

Gene 562 ( 1 ) 62 - 69 2015年5月

IGF-1 Gene Expression Is Differentially Regulated by Estrogen Receptors alpha and beta in Mouse Endometrial Stromal Cells and Ovarian Granulosa Cells 査読

Yuki Ogo, Shusuke Taniuchi, Fumiya Ojima, Sayo Hayashi, Itsuo Murakami, Yuka Saito, Sakae Takeuchi, Toshiyuki Kudo, Sumio Takahashi

JOURNAL OF REPRODUCTION AND DEVELOPMENT 60 ( 3 ) 216 - 223 2014年6月

Identification of a feather β-keratin gene exclusively expressed in pennaceous barbule cells of contour feathers in chicken 査読

Kinue Kowata, Minori Nakaoka, Kaori Nishio, Ayaka Fukao, Akira Satoh, Maho Ogoshi, Sumio Takahashi, Masaoki Tsudzuki, Sakae Takeuchi

Gene 542 ( 1 ) 23 - 28 2014年5月

Insulin-like Growth Factor 1(IGF1) mRNA Expression in the Uterus of Streptozotocin (STZ)-treated Diabetic Mice 査読

Yoshie Manabe, Makoto Tochigi, Akiyoshi Moriwaki, Sakae Takeuchi, Sumio Takahashi

Journal of Reproduction and Development 59 ( 4 ) 398 - 404 2013年

Conserved distal promoter of the agouti signaling protein (ASIP) gene controls sexual dichromatism in chickens 査読

Eri Oribe, Ayaka Fukao, Chihiro Yoshihara, Misa Mendori, Karen G Rosal, Sumio Takahashi, Eri Oribe, Ayaka Fukao, Chihiro Yoshihara, Misa Mendori, Karen G Rosal, Sumio Takahashi, Sakae Takeuchi

General and Comparative Endocrinology 177 ( 2 ) 231 - 237 2012年6月

Elaborate color patterns of individual chicken feathers may be formed by the agouti signaling protein 査読国際誌

Yoshihara, C. Fukao, A. Ando, K. Tashiro, Y. Taniuchi, S. Takahashi, Yoshihara, C., Fukao, A., Ando, K., Tashiro, Y., Taniuchi, S., Takahashi, S. Takeuchi, S

General and Comparative Endocrinology 175 ( 3 ) 495 - 499 2012年2月

Pit-1w may regulate prolactin gene expression in mouse testis 査読

Maeda, K, Taniuchi, S, Takahashi, S, Takeuchi, S

General and Comparative Endocrinology 175 ( 00 ) 180 - 184 2012年

Transforming growth factor- mRNA expression and its possible roles in mouse endometrial stromal cells 査読

Tetsuya Maekawa, Atsuko Sakuma, Shusuke Taniuchi, Yuki Ogo, Taisen Iguchi, Sakae Takeuchi, Sumio Takahashi

Zoological Science 29 ( 6 ) 377 - 383 2012年

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