2026/09/13 更新

写真a

ハヤシ　ケイゴ
林　啓悟
Hayashi Keigo
所属
学術研究院医療開発領域 助教（特任）
職名
助教（特任）
外部リンク
 

論文

  • Impact of Sex, Serostatus, and Smoking on Risk for Rheumatoid Arthritis–Associated Interstitial Lung Disease Subtypes

    Gregory C. McDermott, Keigo Hayashi, Pierre‐Antoine Juge, Ritu Gill, Suzanne Byrne, Staci Gagne, Xiaosong Wang, Misti L. Paudel, Matthew Moll, Michael H. Cho, Kathleen Vanni, Emily Kowalski, Grace Qian, Katarina Bade, Alene Saavedra, Yumeko Kawano, Michael DiIorio, Taylor Wolfgang, Edy Y. Kim, Paul F. Dellaripa, Michael E. Weinblatt, Nancy Shadick, Tracy J. Doyle, Jeffrey A. Sparks

    Arthritis Care & Research   2025年2月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/acr.25432

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  • Serum Biomarkers of Pulmonary Damage and Risk for Progression of Rheumatoid Arthritis–Associated Interstitial Lung Disease

    Sung Hae Chang, Yong-Beom Park, Gregory C. McDermott, Misti L. Paudel, Keigo Hayashi, You-Jung Ha, Jeong Seok Lee, Min Uk Kim, Chan Ho Park, Ji-Won Kim, Jang Woo Ha, Sang Wan Chung, Sung Won Lee, Eun Ha Kang, Yeon Ah Lee, Jung-Yoon Choe, Eun Young Lee, Jeffrey A. Sparks

    The Journal of Rheumatology   2025年1月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3899/jrheum.2024-0713

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  • Effect of Shared Decision‐Making on Trust in Physicians in the Management of Systemic Lupus Erythematosus: The Trust Measurement for Physicians and Patients With Systemic Lupus Erythematosus Prospective Cohort Study

    Ryusuke Yoshimi, Nobuyuki Yajima, Chiharu Hidekawa, Natsuki Sakurai, Nao Oguro, Kenta Shidahara, Keigo Hayashi, Takanori Ichikawa, Dai Kishida, Yoshia Miyawaki, Ken‐ei Sada, Yasuhiro Shimojima, Yuichi Ishikawa, Yuji Yoshioka, Yosuke Kunishita, Daiga Kishimoto, Kaoru Takase‐Minegishi, Yohei Kirino, Shigeru Ohno, Noriaki Kurita, Hideaki Nakajima

    Arthritis Care & Research   2024年12月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1002/acr.25409

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  • Association between sleep-disordered breathing and moderate to severe depression in systemic lupus erythematosus: the TRUMP2-SLE study

    Yuichi Ishikawa, Nao Oguro, Takanori Ichikawa, Dai Kishida, Natsuki Sakurai, Chiharu Hidekawa, Kenta Shidahara, Keigo Hayashi, Yoshia Miyawaki, Yasuhiro Shimojima, Ryusuke Yoshimi, Ken-ei Sada, Nobuyuki Yajima, Noriaki Kurita

    2024年8月

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  • Fractures in Patients With Acute Calcium Pyrophosphate Crystal Arthritis Versus Matched Comparators in a Large Cohort Study

    Sara K. Tedeschi, Keigo Hayashi, Ann Rosenthal, Muneet Gill, Javier Marrugo, Sho Fukui, Ellen Gravallese, Daniel H. Solomon

    Arthritis & Rheumatology   2024年6月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    <jats:sec><jats:title>Objective</jats:title><jats:p>Calcium pyrophosphate deposition (CPPD) disease was associated with osteopenia in two cross‐sectional studies. We compared fracture risks in patients with acute calcium pyrophosphate (CPP) crystal arthritis versus matched comparators.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We performed a longitudinal cohort study using electronic health record data from a single large academic health system, with data from 1991 to 2023. Patients with one or more episodes of acute CPP crystal arthritis were matched to comparators on the index date (first documentation of “pseudogout” or synovial fluid CPP crystals or matched encounter) and first encounter in the health system. The primary outcome was first fracture at the humerus, wrist, hip, or pelvis. We excluded patients with fracture before the index date. Covariates included demographics, body mass index, smoking, comorbidities, health care use, glucocorticoids, and osteoporosis treatments. We estimated incidence rates and adjusted hazard ratios for fracture. Sensitivity analyses excluded patients prescribed glucocorticoids, patients prescribed osteoporosis treatments, or patients with rheumatoid arthritis and additionally adjusted for chronic kidney disease.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We identified 1,148 patients with acute CPP crystal arthritis matched to 3,730 comparators, with a mean age of 73 years. Glucocorticoids and osteoporosis treatments were more frequent in the acute CPP crystal arthritis cohort. Fracture incidence rates were twice as high in the acute CPP crystal arthritis cohort (11.7 per 1,000 person‐years) versus comparators (5.5 per 1,000 person‐years). After multivariable adjustment, fracture relative risk was twice as high in the acute CPP crystal arthritis cohort (hazard ratio 1.8 [95% confidence interval 1.3–2.3]); results were similar in sensitivity analyses.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In this first published study of fractures and CPPD, fracture risk was nearly doubled in patients with acute CPP crystal arthritis.</jats:p></jats:sec>

    DOI： 10.1002/art.42798

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  • Identifying the association between serum urate levels and gout flares in patients taking urate-lowering therapy: a post hoc cohort analysis of the CARES trial with consideration of dropout

    Sara K Tedeschi, Keigo Hayashi, Yuqing Zhang, Hyon Choi, Daniel H Solomon

    Annals of the Rheumatic Diseases   2024年5月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    <jats:sec><jats:title>Objective</jats:title><jats:p>To investigate gout flare rates based on repeated serum urate (SU) measurements in a randomised controlled trial of urate-lowering therapy (ULT), accounting for dropout and death.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We performed a secondary analysis using data from Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout, which randomised participants to febuxostat or allopurinol, titrated to target SU &lt;6 mg/dL with flare prophylaxis for 6 months. SU was categorised as ≤3.9, 4.0–5.9, 6.0–7.9, 8.0–9.9 or ≥ 10 mg/dL at each 3–6 month follow-up. The primary outcome was gout flare. Poisson regression models, adjusted for covariates and factors related to participant retention versus dropout, estimated gout flare incidence rate ratios by time-varying SU category.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Among 6183 participants, the median age was 65 years and 84% were male. Peak gout flare rates for all SU categories were observed in months 0–6, coinciding with the initiation of ULT and months 6–12 after stopping prophylaxis. Flare rates were similar across SU groups in the initial year of ULT. During months 36–72, a dose–response relationship was observed between the SU category and flare rate. Lower flare rates were observed when SU ≤3.9 mg/dL and greater rates when SU ≥10 mg/dL, compared with SU 4.0–5.9 mg/dL (p for trend &lt;0.01).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Gout flare rates were persistently higher when SU ≥6 mg/dL after the first year of ULT after accounting for censoring. The spike in flares in all categories after stopping prophylaxis suggests a longer duration of prophylaxis may be warranted.</jats:p></jats:sec>

    DOI： 10.1136/ard-2024-225761

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  • Effectiveness and tolerability of antifibrotics in rheumatoid arthritis-associated interstitial lung disease

    Pierre-Antoine Juge, Keigo Hayashi, Gregory C. McDermott, Kathleen M.M. Vanni, Emily Kowalski, Grace Qian, Katarina Bade, Alene Saavedra, Philippe Dieudé, Paul F. Dellaripa, Tracy J. Doyle, Jeffrey A. Sparks

    Seminars in Arthritis and Rheumatism   2024年2月

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    記述言語：英語   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1016/j.semarthrit.2023.152312

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  • Effect of Attending Rheumatologists’ Big 5 Personality Traits on Patient Trust in Patients With Systemic Lupus Erythematosus: The TRUMP2-SLE Project

    Nao Oguro, Nobuyuki Yajima, Yuichi Ishikawa, Natsuki Sakurai, Chiharu Hidekawa, Takanori Ichikawa, Dai Kishida, Keigo Hayashi, Kenta Shidahara, Yoshia Miyawaki, Ryusuke Yoshimi, Ken-ei Sada, Yasuhiro Shimojima, Noriaki Kurita

    The Journal of Rheumatology   2024年2月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3899/jrheum.2023-0603

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  • The impact of attending rheumatologist’s Big Five personality traits on systemic lupus erythematosus patients’ trust in their rheumatologist: the TRUMP2-SLE project

    Nao Oguro, Nobuyuki Yajima, Yuichi Ishikawa, Natsuki Sakurai, Chiharu Hidekawa, Takanori Ichikawa, Dai Kishida, Keigo Hayashi, Kenta Shidahara, Yoshia Miyawaki, Ryusuke Yoshimi, Ken-ei Sada, Yasuhiro Shimojima, Noriaki Kurita

    2023年5月

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  • Effect of Communicative and Critical Health Literacy on Trust in Physicians Among Patients With Systemic Lupus Erythematosus (SLE): The TRUMP2-SLE Project

    Nao Oguro, Nobuyuki Yajima, Yoshia Miyawaki, Ryusuke Yoshimi, Yasuhiro Shimojima, Ken-ei Sada, Keigo Hayashi, Kenta Shidahara, Natsuki Sakurai, Chiharu Hidekawa, Dai Kishida, Takanori Ichikawa, Yuichi Ishikawa, Noriaki Kurita

    The Journal of Rheumatology   2023年5月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.3899/jrheum.220678

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  • Trust in the attending rheumatologist, health-related hope, and medication adherence among Japanese patients with systemic lupus erythematosus: the TRUMP2-SLE project

    Noriaki Kurita, Nao Oguro, Yoshia Miyawaki, Chiharu Hidekawa, Natsuki Sakurai, Takanori Ichikawa, Yuichi Ishikawa, Keigo Hayashi, Kenta Shidahara, Dai Kishida, Ryusuke Yoshimi, Ken-ei Sada, Yasuhiro Shimojima, Nobuyuki Yajima

    2022年7月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Cold Spring Harbor Laboratory  

    DOI： 10.1101/2022.07.06.22277337

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  • Real-world data on vitamin D supplementation and its impacts in systemic lupus erythematosus: Cross-sectional analysis of a lupus registry of nationwide institutions (LUNA)

    Keigo Hayashi, Ken-Ei Sada, Yosuke Asano, Yu Katayama, Keiji Ohashi, Michiko Morishita, Yoshia Miyawaki, Haruki Watanabe, Takayuki Katsuyama, Mariko Narazaki, Yoshinori Matsumoto, Nobuyuki Yajima, Ryusuke Yoshimi, Yasuhiro Shimojima, Shigeru Ohno, Hiroshi Kajiyama, Kunihiro Ichinose, Shuzo Sato, Michio Fujiwara, Jun Wada

    PLOS ONE   2022年6月

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    掲載種別：研究論文（学術雑誌）  

    DOI： 10.1371/journal.pone.0270569

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  • Fine Specificity Protein Antibodies and Prediction of Rheumatoid Arthritis-Associated Interstitial Lung Disease

    Vanessa Kronzer, Keigo Hayashi, Kazuki Yoshida, John M. Davis, Gregory McDermott, Weixing Huang, Paul Dellaripa, Jing Cui, Vivi Feathers, Ritu Gill, Hiroto Hatabu, Mizuki Nishino, Rachel Blaustein, Cynthia S. Crowson, William Robinson, jeremy sokolove, Katherine Liao, Michael Weinblatt, Nancy Shadick, Tracy Doyle, Jeffrey A. Sparks

    2022年

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  • Lymphoproliferative disease in a patient with Takayasu arteritis and ulcerative colitis

    Yosuke Asano, Ken-Ei Sada, Keigo Hayashi, Yuriko Yamamura, Sumie Hiramatsu, Keiji Ohashi, Yoshia Miyawaki, Michiko Morishita, Haruki Watanabe, Yoshinori Matsumoto, Tomoko Kawabata, Noriyuki Tanaka, Sakiko Hiraoka, Jun Wada

    Modern Rheumatology Case Reports   3 ( 1 )   34 - 37   2019年1月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：Informa {UK} Limited  

    DOI： 10.1080/24725625.2018.1507271

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  • Thrombocytosis as a prognostic factor in polymyalgia rheumatica: characteristics determined from cluster analysis

    Keigo Hayashi, Keiji Ohashi, Haruki Watanabe, Ken-Ei Sada, Kenta Shidahara, Yosuke Asano, Sumie Hiramatsu Asano, Yuriko Yamamura, Yoshia Miyawaki, Michiko Morishita, Yoshinori Matsumoto, Tomoko Kawabata, Jun Wada

    Therapeutic Advances in Musculoskeletal Disease   11   2019年1月

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    掲載種別：研究論文（学術雑誌）   出版者・発行元：{SAGE} Publications  

    DOI： 10.1177/1759720X19864822

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