2025/08/02 更新

写真a

アヤダ ヨシユキ
綾田 善行
Ayada Yoshiyuki
所属
医歯薬学域 助教
職名
助教
外部リンク

研究キーワード

  • 病理

  • 骨軟部腫瘍

  • リンパ腫

研究分野

  • ライフサイエンス / 人体病理学

学歴

  • 岡山大学大学院   医歯薬学総合研究科病理学(腫瘍病理)  

    2020年4月 - 2024年3月

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  • 岡山大学   Medical School  

    2012年4月 - 2018年3月

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経歴

  • 岡山大学大学院医歯薬学総合研究科   病理学(腫瘍病理)   助教

    2025年4月 - 現在

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  • 岡山大学病院   病理診断科   助教

    2024年4月 - 2025年3月

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  • 岡山大学大学院医歯薬学総合研究科   病理学(腫瘍病理)   博士課程-大学院生

    2020年4月 - 2024年3月

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  • 香川県立中央病院   卒後臨床研修センター   初期研修医

    2018年4月 - 2020年3月

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所属学協会

  • 日本臨床細胞学会

    2023年12月 - 現在

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  • 日本病理学会

    2019年4月 - 現在

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論文

  • Occult cartilaginous choristoma in a child with myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis. 国際誌

    Sayaka Enomoto, Hiroki Tsuchiya, Yoshiyuki Ayada, Yoshiki Takai, Toshiki Takenouchi

    Journal of neuroimmunology   406   578674 - 578674   2025年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Myelin oligodendrocyte glycoprotein antibody-associated disease is a central inflammatory demyelinating disorder that cause diverse neurological symptoms. Paraneoplastic neurologic syndromes occur in association with malignant neoplasms and manifest with a wide range of neuropsychiatric symptoms. Paraneoplastic neurological syndrome is rare in myelin oligodendrocyte glycoprotein antibody-associated disease and, when reported, is typically seen in adults. Herein, we report a 3-year-old girl who presented with lower limb paralysis, urinary retention, and seropositivity for myelin oligodendrocyte glycoprotein antibody. Her symptoms did not respond to various immunotherapies. She was incidentally found to have a cartilaginous choristoma in the neck, after surgical resection of which, she showed symptomatic recovery without recurrence. Immunohistochemical analysis of the resected tumor revealed expression of myelin oligodendrocyte glycoprotein within the cartilage tissue. Based on this case experience, children presenting with myelin oligodendrocyte glycoprotein antibody-associated disease who fail to respond to immunotherapies may need prompt screening for occult tumors.

    DOI: 10.1016/j.jneuroim.2025.578674

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  • Successful immunotherapy with ipilimumab and nivolumab in a patient with pulmonary sclerosing pneumocytoma. 国際誌

    Yumi Inukai-Motokura, Kiichiro Ninomiya, Takahiro Baba, Hiroki Omori, Tetsuya Takeguchi, Mari Uno, Yoshiyuki Ayada, Takehiro Tanaka, Yoshinobu Maeda, Kadoaki Ohashi

    International cancer conference journal   14 ( 1 )   60 - 63   2025年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Pulmonary sclerosing pneumocytoma (PSP) is a rare form of lung cancer that occasionally presents with lymph node and extrapulmonary metastases, and multiple lesions. The treatment of metastatic PSP remains undefined. This study reports the case of a 48-year-old female patient diagnosed with PSP following surgical intervention for a solitary nodule in the left lower lobe. Four years later, recurrence occurred in the left hilar and mediastinal lymph nodes, necessitating an additional resection. Concurrently, sacral metastases developed and required palliative radiotherapy. Genetic analysis identified an AKT1 E17K mutation, characteristic of PSP, and absence of programmed cell death ligand 1 (PD-L1) expression in the tumor. Two years post-recurrence, the tumor recurred in the left mammary gland and mediastinal lymph nodes. Combination immunotherapy with ipilimumab and nivolumab yielded a significantly positive response in this metastatic PSP case. This is the first reported case of successful treatment of multiple distant metastatic PSP with ipilimumab and nivolumab, following the failure of various local treatments. Further case series are warranted to validate the efficacy of immunotherapy in metastatic PSP.

    DOI: 10.1007/s13691-024-00737-8

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  • Intracardiac Echocardiography-Guided Biopsy for a Giant Cardiac Angiosarcoma with Extensive Invasion.

    Yoshitake Fukuda, Kazufumi Nakamura, Koji Nakagawa, Hironobu Toda, Yuki Otsuka, Yohei Masuda, Yoshiaki Soejima, Masahiro Tabata, Yoshiyuki Ayada, Gentaro Kato, Shingo Kasahara, Fumio Otsuka, Shinsuke Yuasa

    International heart journal   66 ( 4 )   706 - 711   2025年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Cardiac angiosarcoma is a rare malignant tumor with a poor prognosis. Because of its aggressive nature, early pathological diagnosis is essential. Previous studies have reported the efficacy of intracardiac echocardiography (ICE) -guided biopsy for unknown cardiac masses; however, its application is unclear. Herein, we describe a case of a giant cardiac angiosarcoma with extensive invasion, successfully diagnosed using ICE-guided biopsy. A 52-year-old man with palpitations and facial edema was admitted to our hospital. Contrast-enhanced computed tomography (CT) revealed a giant hypervascular tumor in the right atrium, extending into nearby structures, including the interatrial septum and left atrial roof. The tumor was initially suspected to be either a mediastinal tumor with cardiac invasion or a primary cardiac tumor. Given the high bleeding risk associated with percutaneous CT-guided or thoracoscopic biopsies, an ICE-guided biopsy of the right atrial mass was performed using a steerable sheath, without complications. The patient was diagnosed with angiosarcoma and underwent surgical resection. Intra-operative evaluation revealed that the tumor was confined to the pericardium with no mediastinal invasion, confirming the diagnosis of primary cardiac angiosarcoma. The patient underwent postoperative chemotherapy and radiotherapy, and is alive 7 months after surgery, demonstrating that ICE-guided biopsy using a steerable sheath is a safe and effective diagnostic tool for cardiac masses, particularly those with malignant characteristics and extensive invasion.

    DOI: 10.1536/ihj.25-105

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  • Treatment of Tenosynovial Giant Cell Tumor of the Cervical Spine with Postoperative Anti-RANKL Antibody (Denosumab) Administration.

    Yuichi Hirata, Takayuki Nagase, Susumu Sasada, Yoshiyuki Ayada, Hayato Miyake, Chiaki Sugahara, Hidetaka Yamamoto, Yoshinao Oda, Takao Yasuhara, Shota Tanaka

    Acta medica Okayama   78 ( 6 )   469 - 474   2024年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Tenosynovial giant cell tumor (TGCT) is a fibrous histiocytic tumor originating in the synovial membrane. While cervical TGCT may not be considered a common diagnosis preoperatively because it is relatively rare, it has a high recurrence rate and should be considered. Total resection is preferable, but it can be challenging due to the risk of damaging the vertebral artery. Denosumab has shown effectiveness as a postoperative treatment for osteolytic bone lesion. Denosumab administration coupled with close follow-up might offer an effective postoperative treatment option for unresectable TGCT with bone invasion.

    DOI: 10.18926/AMO/67877

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  • Response to Imatinib in a Patient With Gastric Adenocarcinoma With KIT Q556_K558 In-Frame Deletion: A Case Report. 国際誌

    Kiichiro Ninomiya, Daisuke Ennishi, Kunio Okamoto, Midori Ando, Satoko Nakamura, Shuta Tomida, Yoshiyuki Ayada, Go Makimoto, Eiki Ichihara, Natsuko Okita, Shinichi Toyooka, Yoshinobu Maeda, Masahiro Tabata

    JCO precision oncology   8   e2400228   2024年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Imatinib may be a useful targeted agent for patients with advanced gastric adenocarcinoma who have KIT mutations.

    DOI: 10.1200/PO.24.00228

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  • Extranodal natural killer/T-cell lymphoma coexisting with peripheral T-cell lymphoma, not otherwise specified.

    Kenta Hayashino, Chikamasa Yoshida, Yoshiyuki Ayata, Ryouya Yukawa, Aya Komura, Makoto Nakamura, Yusuke Meguri, Kazuhiko Yamamoto, Wakako Oda, Kenji Imajo

    Journal of clinical and experimental hematopathology : JCEH   64 ( 1 )   52 - 58   2024年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We report the case of a 52-year-old male who presented to our hospital with cervical lymphadenopathy. Lymph node biopsy revealed small atypical lymphoid cells positive for CD3 and CD5 and negative for CD56 and Epstein-Barr virus (EBV)-encoded small RNA (EBER) by in situ hybridization. CD4-positive cells and CD8-positive cells were mixed in almost equal numbers. He was diagnosed with peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). The patient received one cycle of chemotherapy, resulting in severe sepsis. While undergoing treatment in the intensive care unit with an antimicrobial agent and prednisone, ascitic fluid appeared. Abdominal aspiration revealed neutrophil-predominant ascites and microbiological studies revealed Candida albicans. However, ascites did not improve when treated with micafungin for Candida peritonitis. Abdominal aspiration was re-performed, and atypical lymphoid cells that were positive for CD3 and CD56 were detected. EBV-DNA levels in whole blood were significantly elevated. Atypical lymphoid cells were positive for EBER by in situ hybridization and Southern blot analysis showed EBV terminal repeat monoclonal patterns. Bone marrow examination revealed the same atypical lymphoid cells. Therefore, the patient was diagnosed with extranodal natural killer/T-cell lymphoma (ENKTL) with bone marrow involvement 3 months after the diagnosis of PTCL-NOS. Complications associated with PTCL-NOS and ENKTL are rare. PTCL-NOS, chemotherapy, sepsis, and prednisone might have led to immunodeficiency and reactivation of EBV, which might be one of the pathophysiologies for developing ENKTL. Our case indicates that measuring EBV-DNA in the blood is a simple and prompt examination to detect complications of EBV-associated lymphoma.

    DOI: 10.3960/jslrt.23049

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  • Kimura disease forming a human polyomavirus 6-negative parotid gland nodule with prominent squamous metaplasia in a young female: A case report. 国際誌

    Kenji Yorita, Tatsuya Fujii, Toshitaka Nagao, Ichiro Murakami, Yumiko Hashida, Tomonori Higuchi, Masanori Daibata, Makoto Toi, Yoshiyuki Ayada, Takuro Igawa

    Radiology case reports   18 ( 5 )   1933 - 1938   2023年5月

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    記述言語:英語  

    A case of an asymptomatic 19-year-old woman with Kimura disease presenting with a nodule in the right parotid gland is presented. She had a medical history of atopic dermatitis and noticed a mass on her right-side neck. Cervical lymphadenopathy was clinically diagnosed. The initial management plan was to observe the lesion, which had enlarged from 1 cm to 2 cm in diameter 6 months later. An excisional biopsy was performed, and the pathology confirmed an eosinophil-containing inflammatory parotid gland lesion with many squamous nests and cysts, mimicking a parotid gland tumor. High serum immunoglobulin E levels, peripheral blood eosinophilia, and pathological and genetic diagnoses confirmed Kimura disease. The lesion tested negative for human polyomavirus 6. No recurrence was observed 15 months after the biopsy. The prognosis of Kimura disease without human polyomavirus 6 infection may be favorable; however, further validation of this hypothesis is required as only 5 or 6 cases of Kimura disease have been evaluated for this viral infection. Proliferative squamous metaplasia occurring in parotid gland lesions of Kimura disease is rare and may complicate the diagnostic imaging and pathological diagnosis.

    DOI: 10.1016/j.radcr.2023.02.027

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  • Immunohistochemistry for IRTA1 and MNDA helps differentiate gastric MALT lymphoma from chronic gastritis/reactive lymphocyte hyperplasia.

    Yoshiyuki Ayada, Takuro Igawa, Yusuke Naoi, Kyosuke Horikawa, Tetsuya Tabata, Takehiro Tanaka, Tadashi Yoshino

    Journal of clinical and experimental hematopathology : JCEH   62 ( 4 )   195 - 201   2022年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    It is difficult to histologically differentiate extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) from chronic gastritis (CG)/ reactive lymphoid hyperplasia (RLH). To determine whether immunohistochemistry for IRTA1 and MNDA can differentiate gastric MALT lymphoma from CG/RLH, we investigated 81 stomach biopsy specimens [Wotherspoon grade (WG) 1, 11 cases; WG 2, 9 cases; WG 3, 20 cases; WG 4, 31 cases; and WG 5, 10 cases]. According to a previously reported algorithm involving PCR for immunoglobulin heavy (IgH) chain locus rearrangement, all 81 cases were divided into three groups: CG/RLH (55 cases), MALT lymphoma (19 cases) groups, and IgH undetectable group (7 cases). We analyzed the CG/RLH and MALT lymphoma groups. The median percentage of IRTA1-positive cells was 0% (range 0%-90.6%) in the CG/RLH group and 43.5% (range 0%-97.6%) in the MALT lymphoma group (p < 0.0001). The median percentage of MNDA-positive cells was 32.4% (range 0%-97.6%) in the CG/RLH group and 55.1% (range 0%-97.6%) in the MALT lymphoma group (p = 0.0044). These results indicate that immunohistochemistry for IRTA1 and MNDA can help differentiate gastric MALT lymphoma from CG/RLH.

    DOI: 10.3960/jslrt.22021

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  • Overexpression of folate receptor alpha is an independent prognostic factor for outcomes of pancreatic cancer patients.

    Shizuma Omote, Katsuyoshi Takata, Takehiro Tanaka, Tomoko Miyata-Takata, Yoshiyuki Ayada, Mai Noujima-Harada, Rika Omote, Tetsuya Tabata, Yasuharu Sato, Tatsuya Toyokawa, Hironari Kato, Takahito Yagi, Hiroyuki Okada, Tadashi Yoshino

    Medical molecular morphology   51 ( 4 )   237 - 243   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Pancreatic cancer has a poor prognosis; hence, novel prognostic markers and effective therapeutic targets should be identified. We aimed to evaluate folate receptor alpha (FR-α) expression in pancreatic cancer and examine its association with clinicopathological features. We utilized tissue samples from 100 primary pancreatic cancer patients who underwent surgery. FR-α was expressed in 37 of 100 cases (37%). The FR-α-positive group (median, 18.8 months) had a significantly poorer prognosis than the FR-α-negative group [median 21.3 months; HR 1.89 (1.12-3.12); P = 0.017]. These groups were not significantly different regarding progression-free survival (P = 0.196). Furthermore, other serum tumor markers including CA19-9 (mean, 186 vs. 822 U/ml; P = 0.001), Dupan-2 (286 vs. 1133 U/ml; P = 0.000), and Span-1 (69.7 vs. 171.9 U/ml; P = 0.006) were significantly downregulated in the FR-α-positive group. CA19-9 was another prognostic factor, in addition to FR-α, and patient prognosis showed clear stratification curves with the expression of these two molecules. Along with CA19-9, FR-α expression was an independent prognostic factor for the overall survival. FR-α and CA19-9 helped predict patient prognosis based on stratification curves.

    DOI: 10.1007/s00795-018-0197-8

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MISC

  • HAVCR2ホモ接合型変異を有し家族内発症した皮下脂肪織炎様T細胞リンパ腫

    植田 裕子, 藤井 伸治, 松原 千哲, 近藤 歌穂, 寺尾 俊紀, 松村 彰文, 清家 圭介, 藤原 英晃, 淺田 騰, 遠西 大輔, 藤井 敬子, 松岡 賢市, 森坂 広行, 綾田 善行, 吉野 正, 前田 嘉信

    臨床血液   65 ( 5 )   465 - 466   2024年5月

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    記述言語:日本語   出版者・発行元:(一社)日本血液学会-東京事務局  

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  • プロスタグランジンI2製剤投与中の肺動脈性肺高血圧症患者に発症した胃病変に対する病理学的検討 査読

    堀川 恭佑, 田中 健大, 荒島 拓馬, 綾田 善行, 小野 早和子, 井川 卓朗, 磯田 哲也, 神農 陽子, 万波 智彦, 山元 英崇

    日本病理学会会誌   113 ( 1 )   376 - 376   2024年2月

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    記述言語:日本語   出版者・発行元:(一社)日本病理学会  

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  • 悪性Triton腫瘍様の組織像とH3K27me3発現消失を呈する脱分化軟骨肉腫の一剖検例 査読

    綾田 善行, 溝渕 光一, 守都 敏晃, 大原 信哉, 小田 義直, 山元 英崇

    日本病理学会会誌   113 ( 1 )   443 - 443   2024年2月

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    記述言語:日本語   出版者・発行元:(一社)日本病理学会  

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  • 【がん遺伝子パネル検査と病理診断】症例提示 悪性骨巨細胞腫の遺伝子異常と組織像の関連

    山元 英崇, 石原 新, 岩崎 健, 綾田 善行, 溝渕 光一, 小田 義直

    病理と臨床   42 ( 1 )   0072 - 0075   2024年1月

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    記述言語:日本語   出版者・発行元:(株)文光堂  

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  • 非典型的な好酸性細胞とDDIT3遺伝子再構成を示す粘液型脂肪肉腫の1例

    綾田善行, 中田英二, 尾崎敏文, 山元英崇

    日本整形外科学会雑誌(CD-ROM)   98 ( 6 )   2024年

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  • 小児期に手術歴のあったcerebral amyloid angiopathyの2例

    吉岡良介, 唐沢康暉, 西堂創, 平野雄大, 坂口雄亮, 竹信敦充, 寺岡暉, 綾田善行, 山元英崇, 本田裕之, 稲生靖, 保谷克巳

    小児の脳神経(Web)   49 ( 3 )   2024年

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  • KIT Q556_K558欠失変異を有する胃腺癌患者に対してイマチニブが著効した1例

    二宮貴一朗, 遠西大輔, 岡本邦夫, 安藤翠, 中村聡子, 冨田秀太, 綾田善行, 槇本剛, 市原英基, 沖田南都子, 豊岡伸一, 前田嘉信, 田端雅弘

    日本癌治療学会学術集会(Web)   62nd   2024年

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  • 【病理診断クイックリファレンス 2023】(第15章)リンパ節・脾臓 トキソプラズマ症

    綾田 善行, 佐藤 康晴

    病理と臨床   41 ( 臨増 )   225 - 225   2023年4月

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    記述言語:日本語   出版者・発行元:(株)文光堂  

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  • 胃MALTリンパ腫と慢性胃炎/反応性リンパ過形成の鑑別におけるIRTA1とMNDAの免疫染色の有用性の検討

    綾田 善行, 井川 卓朗, 堀川 恭佑, 田端 哲也, 田中 健大, 吉野 正

    日本病理学会会誌   112 ( 1 )   359 - 359   2023年3月

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    記述言語:日本語   出版者・発行元:(一社)日本病理学会  

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  • 内視鏡的粘膜切除した印環細胞癌を伴った早期大腸癌(M癌)の1例

    平松 万尚, 砂田 光俊, 松尾 泰治, 松尾 恵輔, 日山 亨, 綾田 善行, 田中 健大

    広島医学   75 ( 3 )   148 - 152   2022年3月

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    記述言語:日本語   出版者・発行元:広島医学会  

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  • 傍腫瘍性神経症候群の合併が疑われたホジキンリンパ腫の一例

    綾田 善行, 井川 卓朗, 田端 哲也, 田中 健大, 佐藤 康晴, 吉野 正

    日本リンパ網内系学会会誌   61   109 - 109   2021年5月

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    記述言語:日本語   出版者・発行元:(一社)日本リンパ網内系学会  

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  • 特異な病理像を呈した免疫チェックポイント阻害剤関連肝障害の1例

    綾田 善行, 筒井 朱美, 妹尾 知典, 永野 拓也, 高口 浩一, 大橋 龍一郎, 安藤 翠

    日本消化器病学会四国支部例会プログラム・抄録集   111回   75 - 75   2019年6月

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    記述言語:日本語   出版者・発行元:日本消化器病学会-四国支部  

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  • 好酸性顆粒状胞体を有するXp11.2転座型腎細胞癌の一例

    綾田 善行, 安藤 翠, 中村 聡子, 黒田 直人, 溝渕 光一

    日本病理学会会誌   108 ( 1 )   466 - 466   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本病理学会  

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  • 葉酸レセプターαは膵癌において高率に発現し予後不良な経過を示す

    綾田 善行, 平部 顕子, 加藤 光晴, 高田 尚良, 高田 友子, 佐藤 康晴, 柳井 広之, 吉野 正

    日本病理学会会誌   104 ( 1 )   516 - 516   2015年3月

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    記述言語:日本語   出版者・発行元:(一社)日本病理学会  

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