研究者詳細 - 牧　尉太

論文 - 牧　尉太

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聴覚障害者における災害時・緊急時の情報伝達の課題と解決に向けた取り組み査読

片岡祐子, 小林有美子, 野田夕月奈, 大守伊織, 牧尉太, 日吉顕太, 本多達也

29 ( 2 ) 124 - 130 2024年5月

Total laparoscopic wedge resection for an intramural ectopic pregnancy using an intraoperative ultrasound system: A case report. 査読

Kotaro Kubo, Atsushi Fujikawa, Tomohiro Mitoma, Sakurako Mishima, Akiko Ohira, Satoe Kirino, Jota Maki, Eriko Eto, Hisashi Masuyama

Asian journal of endoscopic surgery 17 ( 2 ) e13303 2024年4月

記述言語：英語

Intramural pregnancy is a rare form of ectopic pregnancy, and the optimal treatment remains uncertain. We describe a 33-year-old woman (gravida 2, para 0) who visited our hospital with suspected ectopic pregnancy. The patient was asymptomatic and hemodynamically stable. Transvaginal ultrasonography revealed pregnancy at 6 weeks of gestation and a gestational sac and fetal heartbeat in the anterior muscular layer of the uterus, away from the endometrium. The fetal sac measured 26 mm. The serum human chorionic gonadotropin (hCG) level had increased to 27 655 mIU/mL. Accordingly, the patient was diagnosed with an intramural ectopic pregnancy and underwent total laparoscopic wedge resection using intraoperative ultrasonography. The postoperative course was uneventful, and she was discharged after 4 days. Her serum hCG level normalized at 26 days postoperatively. This case indicates that intraoperative laparoscopic ultrasonography seems viable for treating intramural pregnancies.

DOI： 10.1111/ases.13303

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【産婦人科医のための緊急対応サバイバルブック】産科編妊産褥婦の合併疾患への対応法糖尿病性ケトアシドーシス査読

牧尉太

臨床婦人科産科 78 ( 4 ) 308 - 312 2024年4月

帝王切開-疾患構造の変化に対応する新たな取り組み- 子宮創部菲薄化低減を目指す糸の役割 Barbed Sutureによる無結紮子宮再建査読

牧尉太, 増山寿

日本周産期・新生児医学会雑誌 59 ( 4 ) 479 - 481 2024年4月

【帝王切開のネガティブ・インパクトの克服と新たな取り組み】ネガティブ・インパクトの回避に向けた取り組み有棘糸を用いた子宮筋層縫合法査読

牧尉太

産婦人科の実際 73 ( 3 ) 243 - 248 2024年3月

Assessing the efficacy of simulation-based education for paramedics in extended focused assessment with sonography for trauma under physician guidance. 査読国際誌

Akiko Ohira, Jota Maki, Kohei Ageta, Hikari Nakato, Hikaru Oba, Tomohiro Mitoma, Sakurako Mishima, Kazumasa Tani, Satoe Kirino, Eriko Eto, Atsunori Nakao, Hisashi Masuyama

Scientific reports 14 ( 1 ) 4190 - 4190 2024年2月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

We investigated the effectiveness of simulation-based education in Focused Assessment with Sonography for Trauma (FAST) to increase the number of Emergency Medical Technicians (EMTs) capable of performing ultrasound examinations in vehicles under the guidance of a physician. Twenty-eight paramedics watched a 14-min video on the features of the ultrasound system, its use, and the scanning method for each part of the body. Each participant performed four FAST examinations using a portable ultrasound device, and the task performance was rated using the Task Specific Checklist (TSC) and Global Rating Scale (GRS). The time required for visualizing each examination site and each FAST was assessed. The mean time required for the first and fourth FAST was 144.6 ± 52.4 s and 90.5 ± 31.0 s, respectively. The time required for each test significantly decreased with repeated testing (p < 0.001). The time to complete FAST was significantly shortened for the pericardial cavity (33.4 ± 23.1/15.3 ± 10.6 s, p < 0.01), right thoracic cavity (25.2 ± 11.8/12.1 ± 8.3 s, p < 0.01), Morrison fossa (19.1 ± 10.8/10.8 ± 6.3 s, p < 0.05), and left thoracic cavity (19.0 ± 8.3/15.6 ± 8.3 s, p < 0.05). TSC and GRS scores were elevated, and all EMTs could obtain valid images. The combination of a brief video lecture and hands-on training significantly reduced the time required for FAST performance. Moreover, repeated practice enabled the EMTs to efficiently obtain accurate and clinically useful images.

DOI： 10.1038/s41598-024-54779-2

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Crucial factors for implementing treatment strategies in intractable atonic postpartum haemorrhage: early phase contrast medium extravasation on dynamic CT 査読

T. Mitoma, J. Maki, A. Suemori, C. Kuriyama, K. Hayata, H. Masuyama

Clinical Radiology 79 ( 1 ) 73 - 79 2024年1月

Association of Regular Cervical Cancer Screening with Socioeconomic, COVID-19 Infection and Vaccine Status Among Japanese Population: Cohort Observational Study. 査読国際誌

Tomohiro Mitoma, Jota Maki, Hikaru Ooba, Chikako Ogawa, Hisashi Masuyama, Takahiro Tabuchi

International journal of general medicine 17 541 - 551 2024年

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: Among the Organisation for Economic Co-operation and Development countries, Japan has one of the lowest cervical cancer screening coverages. Cancer screening coverage has worsened due to the coronavirus disease of 2019 (COVID-19) pandemic. This study investigated the relationship between socioeconomic background, COVID-19 infection history and vaccine status, and regular cervical cancer screening (CCS) during the two years of the COVID-19 era in Japan. PATIENTS AND METHODS: We used data from the Japan COVID-19 and Society Internet Survey, a nationwide, Internet-based, self-report cohort observational study conducted in 2022. The outcome variable was identified by asking whether the participants had undergone CCS within the last two years. Cervical cytology was performed in Japan by brushing the external cervical os. This study used multivariate log-binomial regression models to evaluate inequalities during regular checkups for CCS. Adjusted prevalence ratios (APRs) with 95% confidence intervals (CIs) were estimated to incorporate the socioeconomic background variables. RESULTS: Of the 12,066 participants, 5597 (46.4%) had undergone regular CCS for over two years. The prevalence ratio (PR) of patients who underwent CCS was 0.70 for those in their 20s and 0.78 for those in their 60s, compared to those in their 40s. Socioeconomic inequities were found in the following groups: unemployed/student, unmarried, high school graduate or lower, and household income below 4 million Yen. Our final multivariate analysis revealed that participants who were in their 20s or 60s, had a household income below 4 million Yen, were unmarried, had no annual health check-ups, and were unvaccinated with COVID-19 were at a higher risk of not undergoing CCS. CONCLUSION: The relationship between socioeconomic inequality and CCS hesitancy is prevalent among younger participants. The CCS coverage in Japan during the COVID-19 pandemic year (2020-2022) was not low compared with the pre-pandemic era.

DOI： 10.2147/IJGM.S453675

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Net119緊急通報システムを補助するサブシステムの構想と開発査読

山下範之, 片岡祐子, 牧尉太

情報処理学会全国大会講演論文集 86th ( 4 ) 2024年

帝王切開創部の菲薄化予防の試み査読

牧尉太

日本産婦人科医会報 76 ( 5 ) 2024年

デジタル田園健康特区での健康医療系サービス実装に関する現状と課題

牧尉太, 牧尉太, 那須保友, 那須保友, 櫻井淳, 櫻井淳, 前田嘉信, 前田嘉信

医療情報学連合大会論文集(CD-ROM) 44th 2024年

周産期医療に関する知識・技術の向上を目的とした研修会を開催

大前允人, 牧尉太

プレホスピタル・ケア 37 ( 6 ) 2024年

Short stature in small-for-gestational-age offspring born to mothers with hypertensive disorders of pregnancy. 査読国際誌

Sakurako Mishima, Takashi Mitsui, Kazumasa Tani, Jota Maki, Eriko Eto, Kei Hayata, Yosuke Washio, Junko Yoshimoto, Hirokazu Tsukahara, Hisashi Masuyama

Hypertension in pregnancy 42 ( 1 ) 2187623 - 2187623 2023年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: To investigate the incidence and risk factors of small-for-gestational age (SGA) short stature at 2 and 3 years of age in SGA offspring born to women with hypertensive disorders of pregnancy (HDP). METHODS: We examined 226 women with HDP whose respective SGA offspring were delivered. RESULTS: Eighty offspring (41.2%) were diagnosed with SGA short stature. The prematurity before 32 weeks of gestation was the most significant factor for catch-up growth failure. CONCLUSION: In SGA offspring born to women with HDP, SGA short stature incidence was high, and the risk factor was prematurity before 32 weeks of gestation.

DOI： 10.1080/10641955.2023.2187623

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救急救命士へのタスクシフト内閣府デジタル田園健康特区での取り組み査読

上田浩平, 平山隆浩, 牧尉太, 増山寿, 那須保友, 中尾篤典

日本在宅救急医学会誌 7 ( 1 ) 9 - 11 2023年10月

Successful myomectomy using barbed sutures at 15 weeks of gestation: A case report. 査読国際誌

Yui Negoro, Michihisa Shiro, Jota Maki, Tsubasa Kokehara, Hisashi Masuyama, Shigeki Yoshida

Case reports in women's health 39 e00550 2023年9月

記述言語：英語

To date, there are no reports on the use of barbed sutures in myomectomy during pregnancy. Herein, successful laparotomic myomectomy at 15 weeks of gestation using barbed sutures is described. A 38-year-old pregnant woman with a large myoma (16 × 11 cm) underwent myomectomy at 15 weeks and 4 days of gestation because of strong pain at the myoma site, a high level of inflammatory markers with degeneration of uterine fibroids, and severe anemia caused by denaturation of myoma. The uterine wall was reconstructed using monofilament absorbable 0 barbed sutures. Unlike conventional sutures, barbed sutures do not retract, so an assistant does not need to hold onto it during reconstruction of the uterine wall, resulting in less pressure and damage to the gravid uterus while maintaining resistance and the ability to hold the tissue under tension. The pregnancy continued with no evidence of myometrial thinning or symptoms of preterm labor. The patient delivered a healthy baby via cesarean section due to partial placenta previa at 36 weeks. The case shows the satisfactory outcome of perinatal myomectomy using barbed sutures during pregnancy.

DOI： 10.1016/j.crwh.2023.e00550

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多角的視点から考えるライフステージと喫煙の影響～大規模データから得た新知見～喫煙と小児期、妊娠期、うつへの影響など加熱式タバコ使用による胎盤早期剥離リスク査読

大羽輝, 牧尉太, 田淵貴大, 増山寿

日本女性栄養・代謝学会誌 29 ( 1 ) 84 - 85 2023年8月

Endothelin-1 production via placental (pro)renin receptor in a mouse model of preeclampsia. 査読国際誌

Sakurako Mishima, Takashi Mitsui, Kazumasa Tani, Hikaru Ooba, Tomohiro Mitoma, Akiko Ohira, Jota Maki, Satoe Kirino, Eriko Eto, Kei Hayata, Hisashi Masuyama

Placenta 138 44 - 50 2023年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

INTRODUCTION: Preeclampsia (PE) pathogenesis is explained by the two-stage disorder theory. However, mechanisms underlying hypertension and proteinuria in PE remain unclear. The role of (pro)renin receptor (PRR) in PE pathology has received special attention. We examined endothelin-1 (ET-1) production via placental PRR in a PE mouse model. METHODS: At 14.5 day-post-coitum (DPC), we performed a reduced uterine perfusion pressure (RUPP) operation, ligating the uterine arteriovenous vessels in female mice. We also infused these mice with a PRR inhibitor, decoy peptide in the handle region of prorenin (HRP) for mice (NH2-RIPLKKMPSV-COOH). At 18.5 DPC, blood, urine, and placenta were collected; fetus and placenta were weighed. We evaluated placental hypoxia using quantitative polymerase chain reaction (PCR), with hypoxia-inducible factor-1α (HIF-1α) as index. We also evaluated PRR, transforming growth factor-β1 (TGF-β1), and ET-1 expression in the placenta using quantitative PCR and western blotting. ET-1 concentration in blood plasma was assessed using enzyme-linked immunosorbent assay. RESULTS: Blood pressure and proteinuria significantly increased, and fetal and placental weights decreased in RUPP mice. HIF-1α, PRR, TGF-β1, and ET-1 expressions considerably increased in RUPP mice placentas. ET-1 concentration in RUPP mice blood plasma was markedly increased. PRR inhibitor suppressed these changes. DISCUSSION: In PE model mice that underwent RUPP treatment, placental hypoxia increased PRR and ET-1 expression suggesting a causative relationship between ET-1 and intracellular PRR signaling. RUPP treatment, when combined with HRP, reversed the effect of elevated ET-1 levels in the model. This study may help to elucidate the pathogenesis of PE considering PRR and ET-1.

DOI： 10.1016/j.placenta.2023.05.002

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【ここまで進んだ産婦人科領域の検査法-先制医療に向けて-】周産期・生殖内分泌妊婦の糖代謝異常の評価査読

増山寿, 衛藤英理子, 牧尉太

産科と婦人科 90 ( 7 ) 732 - 736 2023年7月

帝王切開瘢痕症候群予防的観点から招待査読

牧尉太, 増山寿

産婦人科手術 ( 34 ) 103 - 111 2023年6月

改めて考える周産期医療における手術の役割子宮創部菲薄化低減を目指す糸の役割無結紮縫合による子宮再建術の時代へ招待査読

牧尉太, 増山寿

産婦人科手術 ( 34 ) 39 - 43 2023年6月

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