Faculty Profiles - MAKI Jota

Papers - MAKI Jota

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Assessing the efficacy of simulation-based education for paramedics in extended focused assessment with sonography for trauma under physician guidance. Reviewed International journal

Akiko Ohira, Jota Maki, Kohei Ageta, Hikari Nakato, Hikaru Oba, Tomohiro Mitoma, Sakurako Mishima, Kazumasa Tani, Satoe Kirino, Eriko Eto, Atsunori Nakao, Hisashi Masuyama

Scientific reports 14 ( 1 ) 4190 - 4190 2024.2

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

We investigated the effectiveness of simulation-based education in Focused Assessment with Sonography for Trauma (FAST) to increase the number of Emergency Medical Technicians (EMTs) capable of performing ultrasound examinations in vehicles under the guidance of a physician. Twenty-eight paramedics watched a 14-min video on the features of the ultrasound system, its use, and the scanning method for each part of the body. Each participant performed four FAST examinations using a portable ultrasound device, and the task performance was rated using the Task Specific Checklist (TSC) and Global Rating Scale (GRS). The time required for visualizing each examination site and each FAST was assessed. The mean time required for the first and fourth FAST was 144.6 ± 52.4 s and 90.5 ± 31.0 s, respectively. The time required for each test significantly decreased with repeated testing (p < 0.001). The time to complete FAST was significantly shortened for the pericardial cavity (33.4 ± 23.1/15.3 ± 10.6 s, p < 0.01), right thoracic cavity (25.2 ± 11.8/12.1 ± 8.3 s, p < 0.01), Morrison fossa (19.1 ± 10.8/10.8 ± 6.3 s, p < 0.05), and left thoracic cavity (19.0 ± 8.3/15.6 ± 8.3 s, p < 0.05). TSC and GRS scores were elevated, and all EMTs could obtain valid images. The combination of a brief video lecture and hands-on training significantly reduced the time required for FAST performance. Moreover, repeated practice enabled the EMTs to efficiently obtain accurate and clinically useful images.

DOI： 10.1038/s41598-024-54779-2

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Crucial factors for implementing treatment strategies in intractable atonic postpartum haemorrhage: early phase contrast medium extravasation on dynamic CT Reviewed

T. Mitoma, J. Maki, A. Suemori, C. Kuriyama, K. Hayata, H. Masuyama

Clinical Radiology 79 ( 1 ) 73 - 79 2024.1

Association of Regular Cervical Cancer Screening with Socioeconomic, COVID-19 Infection and Vaccine Status Among Japanese Population: Cohort Observational Study. Reviewed International journal

Tomohiro Mitoma, Jota Maki, Hikaru Ooba, Chikako Ogawa, Hisashi Masuyama, Takahiro Tabuchi

International journal of general medicine 17 541 - 551 2024

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Among the Organisation for Economic Co-operation and Development countries, Japan has one of the lowest cervical cancer screening coverages. Cancer screening coverage has worsened due to the coronavirus disease of 2019 (COVID-19) pandemic. This study investigated the relationship between socioeconomic background, COVID-19 infection history and vaccine status, and regular cervical cancer screening (CCS) during the two years of the COVID-19 era in Japan. PATIENTS AND METHODS: We used data from the Japan COVID-19 and Society Internet Survey, a nationwide, Internet-based, self-report cohort observational study conducted in 2022. The outcome variable was identified by asking whether the participants had undergone CCS within the last two years. Cervical cytology was performed in Japan by brushing the external cervical os. This study used multivariate log-binomial regression models to evaluate inequalities during regular checkups for CCS. Adjusted prevalence ratios (APRs) with 95% confidence intervals (CIs) were estimated to incorporate the socioeconomic background variables. RESULTS: Of the 12,066 participants, 5597 (46.4%) had undergone regular CCS for over two years. The prevalence ratio (PR) of patients who underwent CCS was 0.70 for those in their 20s and 0.78 for those in their 60s, compared to those in their 40s. Socioeconomic inequities were found in the following groups: unemployed/student, unmarried, high school graduate or lower, and household income below 4 million Yen. Our final multivariate analysis revealed that participants who were in their 20s or 60s, had a household income below 4 million Yen, were unmarried, had no annual health check-ups, and were unvaccinated with COVID-19 were at a higher risk of not undergoing CCS. CONCLUSION: The relationship between socioeconomic inequality and CCS hesitancy is prevalent among younger participants. The CCS coverage in Japan during the COVID-19 pandemic year (2020-2022) was not low compared with the pre-pandemic era.

DOI： 10.2147/IJGM.S453675

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Conception and development of subsystems to supplement the Net119 emergency call system Reviewed

山下範之, 片岡祐子, 牧尉太

情報処理学会全国大会講演論文集 86th ( 4 ) 2024

帝王切開創部の菲薄化予防の試み Reviewed

牧尉太

日本産婦人科医会報 76 ( 5 ) 2024

Short stature in small-for-gestational-age offspring born to mothers with hypertensive disorders of pregnancy. Reviewed International journal

Sakurako Mishima, Takashi Mitsui, Kazumasa Tani, Jota Maki, Eriko Eto, Kei Hayata, Yosuke Washio, Junko Yoshimoto, Hirokazu Tsukahara, Hisashi Masuyama

Hypertension in pregnancy 42 ( 1 ) 2187623 - 2187623 2023.12

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To investigate the incidence and risk factors of small-for-gestational age (SGA) short stature at 2 and 3 years of age in SGA offspring born to women with hypertensive disorders of pregnancy (HDP). METHODS: We examined 226 women with HDP whose respective SGA offspring were delivered. RESULTS: Eighty offspring (41.2%) were diagnosed with SGA short stature. The prematurity before 32 weeks of gestation was the most significant factor for catch-up growth failure. CONCLUSION: In SGA offspring born to women with HDP, SGA short stature incidence was high, and the risk factor was prematurity before 32 weeks of gestation.

DOI： 10.1080/10641955.2023.2187623

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救急救命士へのタスクシフト内閣府デジタル田園健康特区での取り組み Reviewed

上田浩平, 平山隆浩, 牧尉太, 増山寿, 那須保友, 中尾篤典

日本在宅救急医学会誌 7 ( 1 ) 9 - 11 2023.10

Successful myomectomy using barbed sutures at 15 weeks of gestation: A case report. Reviewed International journal

Yui Negoro, Michihisa Shiro, Jota Maki, Tsubasa Kokehara, Hisashi Masuyama, Shigeki Yoshida

Case reports in women's health 39 e00550 2023.9

Language：English

To date, there are no reports on the use of barbed sutures in myomectomy during pregnancy. Herein, successful laparotomic myomectomy at 15 weeks of gestation using barbed sutures is described. A 38-year-old pregnant woman with a large myoma (16 × 11 cm) underwent myomectomy at 15 weeks and 4 days of gestation because of strong pain at the myoma site, a high level of inflammatory markers with degeneration of uterine fibroids, and severe anemia caused by denaturation of myoma. The uterine wall was reconstructed using monofilament absorbable 0 barbed sutures. Unlike conventional sutures, barbed sutures do not retract, so an assistant does not need to hold onto it during reconstruction of the uterine wall, resulting in less pressure and damage to the gravid uterus while maintaining resistance and the ability to hold the tissue under tension. The pregnancy continued with no evidence of myometrial thinning or symptoms of preterm labor. The patient delivered a healthy baby via cesarean section due to partial placenta previa at 36 weeks. The case shows the satisfactory outcome of perinatal myomectomy using barbed sutures during pregnancy.

DOI： 10.1016/j.crwh.2023.e00550

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多角的視点から考えるライフステージと喫煙の影響～大規模データから得た新知見～喫煙と小児期、妊娠期、うつへの影響など加熱式タバコ使用による胎盤早期剥離リスク Reviewed

大羽輝, 牧尉太, 田淵貴大, 増山寿

日本女性栄養・代謝学会誌 29 ( 1 ) 84 - 85 2023.8

Endothelin-1 production via placental (pro)renin receptor in a mouse model of preeclampsia. Reviewed International journal

Sakurako Mishima, Takashi Mitsui, Kazumasa Tani, Hikaru Ooba, Tomohiro Mitoma, Akiko Ohira, Jota Maki, Satoe Kirino, Eriko Eto, Kei Hayata, Hisashi Masuyama

Placenta 138 44 - 50 2023.7

Language：English Publishing type：Research paper (scientific journal)

INTRODUCTION: Preeclampsia (PE) pathogenesis is explained by the two-stage disorder theory. However, mechanisms underlying hypertension and proteinuria in PE remain unclear. The role of (pro)renin receptor (PRR) in PE pathology has received special attention. We examined endothelin-1 (ET-1) production via placental PRR in a PE mouse model. METHODS: At 14.5 day-post-coitum (DPC), we performed a reduced uterine perfusion pressure (RUPP) operation, ligating the uterine arteriovenous vessels in female mice. We also infused these mice with a PRR inhibitor, decoy peptide in the handle region of prorenin (HRP) for mice (NH2-RIPLKKMPSV-COOH). At 18.5 DPC, blood, urine, and placenta were collected; fetus and placenta were weighed. We evaluated placental hypoxia using quantitative polymerase chain reaction (PCR), with hypoxia-inducible factor-1α (HIF-1α) as index. We also evaluated PRR, transforming growth factor-β1 (TGF-β1), and ET-1 expression in the placenta using quantitative PCR and western blotting. ET-1 concentration in blood plasma was assessed using enzyme-linked immunosorbent assay. RESULTS: Blood pressure and proteinuria significantly increased, and fetal and placental weights decreased in RUPP mice. HIF-1α, PRR, TGF-β1, and ET-1 expressions considerably increased in RUPP mice placentas. ET-1 concentration in RUPP mice blood plasma was markedly increased. PRR inhibitor suppressed these changes. DISCUSSION: In PE model mice that underwent RUPP treatment, placental hypoxia increased PRR and ET-1 expression suggesting a causative relationship between ET-1 and intracellular PRR signaling. RUPP treatment, when combined with HRP, reversed the effect of elevated ET-1 levels in the model. This study may help to elucidate the pathogenesis of PE considering PRR and ET-1.

DOI： 10.1016/j.placenta.2023.05.002

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【ここまで進んだ産婦人科領域の検査法-先制医療に向けて-】周産期・生殖内分泌妊婦の糖代謝異常の評価 Reviewed

増山寿, 衛藤英理子, 牧尉太

産科と婦人科 90 ( 7 ) 732 - 736 2023.7

Authorship：Last author Language：Japanese Publisher：(株)診断と治療社

＜文献概要＞糖代謝異常のスクリーニング法は,妊娠前に糖尿病と診断されていない全妊婦に対して妊娠初期(8～12週)に随時血糖測定(95または100mg/dL)および中期(24～28週)に随時血糖測定(100mg/dL以上)または50gGCT(140mg/dL以上)で異常を認めた場合に75gOGTTを行う.血糖管理のおもな目標は,母体面からみると糖尿病性腎症,網膜症,ケトアシドーシスなどの糖尿病合併症や妊娠高血圧症候群,児の予後からみると妊娠初期の高血糖による胎児奇形および妊娠中後期の早産,巨大児・難産や低血糖,黄疸や呼吸窮迫症候群などの新生児合併症などの発症抑制である.

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J00525&link_issn=&doc_id=20230622010008&doc_link_id=10.34433%2Fog.0000000298&url=https%3A%2F%2Fdoi.org%2F10.34433%2Fog.0000000298&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

帝王切開瘢痕症候群予防的観点から Invited Reviewed

牧尉太, 増山寿

産婦人科手術 ( 34 ) 103 - 111 2023.6

改めて考える周産期医療における手術の役割子宮創部菲薄化低減を目指す糸の役割無結紮縫合による子宮再建術の時代へ Invited Reviewed

牧尉太, 増山寿

産婦人科手術 ( 34 ) 39 - 43 2023.6

帝王切開瘢痕症候群予防的観点から Reviewed

牧尉太, 増山寿

産婦人科手術 ( 34 ) 103 - 111 2023.6

改めて考える周産期医療における手術の役割子宮創部菲薄化低減を目指す糸の役割無結紮縫合による子宮再建術の時代へ Reviewed

牧尉太, 増山寿

産婦人科手術 ( 34 ) 39 - 43 2023.6

Therapeutic plasma exchange in postpartum HELLP syndrome: a case report. Reviewed International journal

Nana Kojima, Kosuke Kuroda, Makiko Tani, Tomoyuki Kanazawa, Kazuyoshi Shimizu, Jota Maki, Hisashi Masuyama, Hiroshi Morimatsu

JA clinical reports 9 ( 1 ) 9 - 9 2023.2

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Postpartum hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome is more difficult to treat than HELLP syndrome during pregnancy. We describe a case of postpartum HELLP syndrome that responded to plasma exchange (PE) therapy. CASE PRESENTATION: A 30-year-old primipara woman was hospitalized for gestational hypertension at 33 weeks of gestation and underwent an emergent cesarean section at 36 weeks and 6 days of gestation due to rapidly progressing pulmonary edema. After delivery, liver dysfunction and a rapid decrease in platelet count were observed, and the patient was diagnosed with severe HELLP syndrome. She experienced multiple organ failure despite intensive care, and PE therapy was initiated. Her general condition dramatically stabilized within a few hours of PE therapy. CONCLUSION: It is controversial whether PE therapy should be used primarily in the management of HELLP syndrome, but early initiation of PE therapy could be effective for severe HELLP syndrome.

DOI： 10.1186/s40981-023-00602-2

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Protocol for a randomised, placebo-controlled, double-blinded clinical trial on the effect of oestrogen replacement on physical performance to muscle resistance exercise for older women with osteoarthritis of knee joint: the EPOK trial Reviewed International journal

Tomohiro Mitoma, Jota Maki, Hikaru Ooba, Eriko Eto, Kasumi Takahashi, Tsunemasa Kondo, Tomohiro Ikeda, Yoko Sakamoto, Toshiharu Mitsuhashi, Hisashi Masuyama

BMC Geriatrics 23 ( 1 ) 104 - 104 2023.2

Authorship：Corresponding author Language：English Publisher：Springer Science and Business Media LLC

Abstract

Background

Knee osteoarthritis (KOA) is highly prevalent in older women, and previous studies suggest the involvement of hormonal factors play a role in the pathogenesis of osteoarthritis. KOA causes musculoskeletal impairment, resulting in decreased physical activity, muscle mass, and strength, which leads to sarcopenia and further increases the burden on healthcare systems. Oestrogen replacement therapy (ERT) improves joint pain and muscle performance in early menopausal women. Muscle resistance exercise (MRE) is a non-pharmacological method that preserves the physical functions of patients with KOA. However, data on short-term oestrogen administration combined with MRE in postmenopausal women, especially in those aged > 65 years, are limited. Therefore, this study presents a protocol of a trial aimed to examine the synergistic effect of ERT and MRE on lower-limb physical performance in older women with KOA.

Methods

We will conduct a double-blinded, randomised placebo-controlled trial in 80 Japanese women aged > 65 years living independently with knee pain. The participants will be randomly categorised into two groups: (1) 12-week MRE programme with transdermal oestrogen gel containing 0.54 mg oestradiol per push and (2) 12-week MRE programme with placebo gel. The primary outcome measured using the 30-s chair stand test, and secondary outcomes (body composition, lower-limb muscle strength, physical performance, self-reported measure of knee pain, and quality of life) will be measured at baseline, 3 months, and 12 months, and these outcomes will be analysed based on the intention-to-treat.

Discussion

The EPOK trial is the first study to focus on the efficacy of ERT on MRE among women aged > 65 years with KOA. This trial will provide an effective MRE to prevent KOA-induced lower-limb muscle weakness, confirming the benefit of short-term oestrogen administration.

Trial registration

Japan Registry of Clinical Trials: jRCTs061210062. Registered 17th December 2021, https://jrct.niph.go.jp/en-latest-detail/jRCTs061210062.

DOI： 10.1186/s12877-023-03828-y

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Other Link： https://link.springer.com/article/10.1186/s12877-023-03828-y/fulltext.html

Postpartum pyomyoma due to Mycoplasma hominis: A case report. Reviewed International journal

Tomohiro Mitoma, Hikaru Oba, Sakurako Mishima, Akiko Ohira, Satoe Kirino, Kazumasa Tani, Jota Maki, Eriko Eto, Kei Hayata, Hisashi Masuyama

Case reports in women's health 36 e00456 2022.10

Language：English

Pyomyoma is a rare condition that causes fever and abdominal pain associated with pregnancy, especially in the postpartum period. An appropriate diagnosis and early medical intervention are required to prevent serious complications. A 38-year-old primigravida with uterine fibroids had fever from the 11th day after cesarean section. The fever did not resolve despite repeated daily administration of broad-spectrum β-lactam antibiotics for 2 weeks. Although the physical examination did not show any lower abdominal pain, a pelvic magnetic resonance scan revealed degenerative fibroids, and myomectomy was performed. Yellow-greenish odorless pus inside the uterus was detected, and Mycoplasma hominis was detected in the pus culture. Mycoplasma species are resistant to broad-spectrum penicillin antibiotics and can cause pyomyoma. Pyomyomas may not cause uterine tenderness, and the causative organism may be difficult to identify; therefore, additional imaging studies should be considered.

DOI： 10.1016/j.crwh.2022.e00456

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糖代謝異常妊婦における母体体組成量および安静時代謝量と出生児体重の関係 Invited Reviewed

衛藤英理子, 横畑理美, 牧尉太, 増山寿

糖尿病と妊娠 22 ( 2 ) S - 112 2022.8

Language：Japanese Publisher：(一社)日本糖尿病・妊娠学会

糖代謝異常妊婦はheavy for date(HFD;在胎不当過体重児)のハイリスクである。糖代謝異常妊婦の体組成量や安静時代謝量の変化が出生児体重の予測因子となるかを研究した。その結果、糖代謝異常群では妊娠前期の安静時代謝量1520kcal/day以上(OR=6.1)と妊娠後期の除脂肪量47.0kg以上(OR=6.8)が出生児体重3500g以上の予測因子として抽出された。糖代謝異常妊婦における除脂肪量や安静時代謝量の変化は出生児体重の予測因子となり得ることより、母体体組成量測定を実施することが、HFD予測の一助となる可能性が示唆された。(著者抄録)

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Kibichuo Town is the first National Stragic Special Zone for innovative business collaboration in Japan: The role of universites in archiving regulatory reform with a vison toward a Digital Gareden City Nation Invited Reviewed

134 ( 2 ) 115 - 118 2022.8

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Papers - MAKI Jota