Research Projects -
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Study of blood glucose kinetics and glycemic control methods with the Real-Time Continuous Glucose Monitoring During labor of gestational diabetes and normal pregnant women.
Grant number：17K16852 2017.04 - 2020.03
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B) Grant-in-Aid for Young Scientists (B)
MAKI JOTA
Grant amount：\3640000 （ Direct expense: \2800000 、 Indirect expense：\840000 ）
Details of blood glucose fluctuations during labor by stage are unknown. Here we investigated whether blood glucose kinetics are affected when the 2nd stage of labor is prolonged (labor dystocia). Japanese pregnant women with gestational diabetes mellitus and normal glucose tolerance test results who underwent perinatal management between May 2016 and March 2019 and gave birth to a single baby vaginally at 37 weeks or later were enrolled. Among the 116 enrolled pregnant women, 52 were excluded. Of the remaining 64, 32 had gestational diabetes mellitus and 32 had normal glucose tolerance. The major outcome of our study is that the prolongation of period 2 resulted in an increased blood glucose at delivery. The prolongation of 2nd stage significantly increased blood glucose kinetics in gestational diabetes mellitus patients (p = 0.022). Regression coefficient indicated that the blood glucose levels increased linearly by about 0.058 mg/dL for every 1-min duration of period 2.