研究者詳細 - 坂本　竜哉

MISC - 坂本　竜哉

分割表示 150 件中 1 - 20 件目／全件表示 >>

Ushimado Marine Institute (UMI), Faculty of Science, Okayama University

竜哉坂本

NIPPON SUISAN GAKKAISHI 88 ( 3 ) 186 - 186 2022年5月

Directors-Council of National Marine and Inland Biological Stations in Japan

竜哉坂本

NIPPON SUISAN GAKKAISHI 88 ( 1 ) 23 - 23 2022年1月

オキシトシンによる脊髄射精中枢を介した男性性機能の調節メカニズム

越智拓海, 越智拓海, 坂本竜哉, 坂本浩隆

日本性機能学会中部総会プログラム・抄録集 32nd 2022年

オキシトシン放出を調節する1回膜貫通型タンパク質CD38のはたらき

坂本浩隆, 越智拓海, 越智拓海, 大坪秋人, 川上奈津子, 坂本竜哉

日本解剖学会総会・全国学術集会講演プログラム・抄録集 127th (CD-ROM) 2022年

ミネラルコルチコイド受容体ノックアウト(MR-KO)メダカにおける異常な視覚依存行動の観察

唐嘉榮, 今野紀文, 中町智哉, 坂本浩隆, 坂本竜哉, 松田恒平

日本比較内分泌学会大会及びシンポジウムプログラム・講演要旨 45th 2021年

ラット精巣におけるオキシトシン・オキシトシン受容体の局在

ZUN Miho, 伊藤隆志, 坂本竜哉, 小谷享, 坂本浩隆, 越智拓海, 越智拓海

Science Journal of Kanagawa University 32 2021年

17β-エストラジオールによる痒み閾値調節

高浪景子, 歌大介, 松田賢一, 河田光博, 河田光博, CARSTENS Earl, 坂本竜哉, 坂本浩隆

日本神経内分泌学会学術集会プログラム・抄録集 47th 2021年

コペプチン動態に着目したバソプレシン前駆体・プロセシング機構の解明

大坪秋人, 川上奈津子, 前嶋翔, 坂本竜哉, 坂本浩隆

バゾプレシン研究会プログラム・講演抄録 31st 2021年

内側視索前野の性的二型核に発現するガストリン放出ペプチド系は雄ラットの性的活性を制御する

前嶋翔, 野村黎, 高浪景子, 坂本竜哉, 坂本浩隆

日本神経内分泌学会学術集会プログラム・抄録集 47th 2021年

扁形動物ヒラムシから紐解くGnRHの祖先型機能

森俊輔, 酒井丈実, 濱田麻友子, 坂本竜哉, 坂本浩隆

日本比較内分泌学会大会及びシンポジウムプログラム・講演要旨 45th 2021年

Oxytocin Influences Male Sexual Activity via Non-synaptic Axonal Release in the Spinal Cord 国際誌

Takumi Oti, Keita Satoh, Daisuke Uta, Junta Nagafuchi, Sayaka Tateishi, Ryota Ueda, Keiko Takanami, Larry J. Young, Antony Galione, John F. Morris, Tatsuya Sakamoto, Hirotaka Sakamoto

Current Biology 31 ( 1 ) 103 - 114 2020年10月

記述言語：英語出版者・発行元：Elsevier BV

Oxytocinergic neurons in the paraventricular nucleus of the hypothalamus that project to extrahypothalamic brain areas and the lumbar spinal cord play an important role in the control of erectile function and male sexual behavior in mammals. The gastrin-releasing peptide (GRP) system in the lumbosacral spinal cord is an important component of the neural circuits that control penile reflexes in rats, circuits that are commonly referred to as the "spinal ejaculation generator (SEG)." We have examined the functional interaction between the SEG neurons and the hypothalamo-spinal oxytocin system in rats. Here, we show that SEG/GRP neurons express oxytocin receptors and are activated by oxytocin during male sexual behavior. Intrathecal injection of oxytocin receptor antagonist not only attenuates ejaculation but also affects pre-ejaculatory behavior during normal sexual activity. Electron microscopy of potassium-stimulated acute slices of the lumbar cord showed that oxytocin-neurophysin-immunoreactivity was detected in large numbers of neurosecretory dense-cored vesicles, many of which are located close to the plasmalemma of axonal varicosities in which no electron-lucent microvesicles or synaptic membrane thickenings were visible. These results suggested that, in rats, release of oxytocin in the lumbar spinal cord is not limited to conventional synapses but occurs by exocytosis of the dense-cored vesicles from axonal varicosities and acts by diffusion-a localized volume transmission-to reach oxytocin receptors on GRP neurons and facilitate male sexual function.

DOI： 10.1016/j.cub.2020.09.089

PubMed

researchmap

Variation of pro‐vasopressin processing in parvocellular and magnocellular neurons in the paraventricular nucleus of the hypothalamus: Evidence from the vasopressin‐related glycopeptide copeptin

Natsuko Kawakami, Akito Otubo, Sho Maejima, Ashraf H. Talukder, Keita Satoh, Takumi Oti, Keiko Takanami, Yasumasa Ueda, Keiichi Itoi, John F. Morris, Tatsuya Sakamoto, Hirotaka Sakamoto

Journal of Comparative Neurology 2020年9月

Introducing the Amphibious Mudskipper Goby as a Unique Model to Evaluate Neuro/Endocrine Regulation of Behaviors Mediated by Buccal Sensation and Corticosteroids

Yukitoshi Katayama, Kazuhiro Saito, Tatsuya Sakamoto

International Journal of Molecular Sciences 21 ( 18 ) 6748 - 6748 2020年9月

出版者・発行元：MDPI AG

Some fish have acquired the ability to breathe air, but these fish can no longer flush their gills effectively when out of water. Hence, they have developed characteristic means for defense against external stressors, including thirst (osmolarity/ions) and toxicity. Amphibious fish, extant air-breathing fish emerged from water, may serve as models to examine physiological responses to these stressors. Some of these fish, including mudskipper gobies such as Periophthalmodon schlosseri, Boleophthalmus boddarti and our Periophthalmus modestus, display distinct adaptational behaviors to these factors compared with fully aquatic fish. In this review, we introduce the mudskipper goby as a unique model to study the behaviors and the neuro/endocrine mechanisms of behavioral responses to the stressors. Our studies have shown that a local sensation of thirst in the buccal cavity—this being induced by dipsogenic hormones—motivates these fish to move to water through a forebrain response. The corticosteroid system, which is responsive to various stressors, also stimulates migration, possibly via the receptors in the brain. We suggest that such fish are an important model to deepen insights into the stress-related neuro/endocrine-behavioral effects.

DOI： 10.3390/ijms21186748

researchmap

Transcriptomic Analysis of the Kuruma Prawn Marsupenaeus japonicus Reveals Possible Peripheral Regulation of the Ovary 招待査読

Naoaki Tsutsui, Yasuhisa Kobayashi, Kouichi Izumikawa, Tatsuya Sakamoto

Frontiers in Endocrinology 11 2020年8月

Vasopressin gene products are colocalised with corticotrophin‐releasing factor within neurosecretory vesicles in the external zone of the median eminence of the Japanese macaque monkey ( Macaca fuscata )

Akito Otubo, Natsuko Kawakami, Sho Maejima, Yasumasa Ueda, John F. Morris, Tatsuya Sakamoto, Hirotaka Sakamoto

Journal of Neuroendocrinology 32 ( 8 ) 2020年8月

Facilitated NaCl Uptake in the Highly Developed Bundle of the Nephron in Japanese Red Stingray Hemitrygon akajei Revealed by Comparative Anatomy and Molecular Mapping

Naotaka Aburatani, Wataru Takagi, Marty Kwok-Sing Wong, Mitsutaka Kadota, Shigehiro Kuraku, Kotaro Tokunaga, Kazuya Kofuji, Kazuhiro Saito, Waichiro Godo, Tatsuya Sakamoto, Susumu Hyodo

Zoological Science 37 ( 5 ) 1 - 1 2020年7月

Detection and Characterization of Estrogen Receptor Beta Expression in the Brain with Newly Developed Transgenic Mice

Shoko Sagoshi, Sho Maejima, Masahiro Morishita, Satoshi Takenawa, Akito Otubo, Keiko Takanami, Tatsuya Sakamoto, Hirotaka Sakamoto, Shinji Tsukahara, Sonoko Ogawa

Neuroscience 438 182 - 197 2020年7月

Ghrelin and food acquisition in wild and cultured Japanese eel (Anguilla japonica)

Takashi Yada, Michihisa Abe, Kenzo Kaifu, Kazuki Yokouchi, Nobuto Fukuda, Sakie Kodama, Hiroshi Hakoyama, Maho Ogoshi, Hiroyuki Kaiya, Tatsuya Sakamoto, Shunsuke Moriyama, Katsumi Tsukamoto

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 245 110700 - 110700 2020年7月

記述言語：英語出版者・発行元：Elsevier BV

To clarify the relationships between growth, endocrine status and habitat characteristics in Japanese eel (Anguilla japonica), plasma and stomach mRNA levels of ghrelin were examined in wild eels captured in the river and the bay, and in cultured eels during and after experimental fasting. Wild juvenile eels captured in freshwater habitats within the river showed significantly higher plasma and stomach mRNA levels of ghrelin than did fish obtained from brackish-water habitats within the bay. In cultured eels experimentally fasted for 4 weeks, plasma and stomach mRNA levels of ghrelin increased. After refeeding, the both parameters returned to the levels observed in continuously feeding control fish. In pigmented elvers, 2 months of feed restriction resulted in a significant increase in whole-body ghrelin mRNA. It is suggested that interaction between ghrelin and feeding is related to their habitats through differential food acquisition in fresh and brackish water environments.

DOI： 10.1016/j.cbpa.2020.110700

Web of Science

researchmap

Current and Future Research at Japanese National Marine and Inland Water Stations

Sakamoto, T.

Ocean Newsletter 2019年12月

Hormonal regulation of thirst in the amphibious ray-finned fish suggests the requirement for terrestrialization during evolution. 国際誌

Yukitoshi Katayama, Yoshio Takei, Makoto Kusakabe, Tatsuya Sakamoto

Scientific reports 9 ( 1 ) 16347 - 16347 2019年11月

記述言語：英語

Thirst has evolved for vertebrate terrestrial adaptation. We previously showed that buccal drying induced a series of drinking behaviours (migration to water-taking water into the mouth-swallowing) in the amphibious mudskipper goby, thereby discovering thirst in ray-finned fish. However, roles of dipsogenic/antidipsogenic hormones, which act on the thirst center in terrestrial tetrapods, have remained unclear in the mudskipper thirst. Here we examined the hormonal effects on the mudskipper drinking behaviours, particularly the antagonistic interaction between angiotensin II (AngII) and atrial natriuretic peptide (ANP) which is important for thirst regulation in mammalian 'forebrain'. Expectedly, intracerebroventricular injection of ANP in mudskippers reduced AngII-increased drinking rate. ANP also suppressed the neural activity at the 'hindbrain' region for the swallowing reflex, and the maintenance of buccopharyngeal water due to the swallowing inhibition may attenuate the motivation to move to water. Thus, the hormonal molecules involved in drinking regulation, as well as the influence of buccopharyngeal water, appear to be conserved in distantly related species to solve osmoregulatory problems, whereas hormonal control of thirst at the forebrain might have been acquired only in tetrapod lineage during evolution.

DOI： 10.1038/s41598-019-52870-7

PubMed

researchmap

　前のページ - 次のページ　

<坂本 竜哉>

MISC - 坂本 竜哉

<坂本　竜哉>

MISC - 坂本　竜哉