Updated on 2021/12/27

写真a

 
YOSHIYAMA Masahiro
 
Organization
Medicine, Dentistry and Pharmaceutical Sciences Professor
Position
Professor
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Degree

  • 歯学博士 ( 徳島大学 )

Research Interests

  • 再生歯科

  • 保存修復学

  • 審美歯科

  • 象牙質接着

  • Dentin bonding

Research Areas

  • Life Science / Conservative dentistry

  • Life Science / Oral biological science

Education

  • The University of Tokushima   歯学研究科   歯学

    - 1987

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    Country: Japan

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  • The University of Tokushima    

    - 1987

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  • The University of Tokushima    

    - 1983

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  • The University of Tokushima   Faculty of Dentistry  

    - 1983

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    Country: Japan

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Research History

  • - 岡山大学医歯薬学総合研究科 教授

    2004

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  • - Professor,Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University

    2004

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Professional Memberships

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Committee Memberships

  • 日本歯科保存学会   理事  

    2021.4 - 2022.3   

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    Committee type:Academic society

  • 日本歯科審美学会   理事  

    2021.4 - 2022.3   

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    Committee type:Academic society

  • 日本接着歯学会   理事  

    2021.4 - 2022.3   

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    Committee type:Academic society

  • 日本再生歯科医学会   名誉会長  

    2021.4 - 2022.3   

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    Committee type:Academic society

  • 象牙質歯髄治療学会   会長  

    2021.4 - 2022.3   

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    Committee type:Academic society

  • 日本歯科保存学会   常任理事(研究活性化委員会)  

    2011   

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    Committee type:Academic society

    日本歯科保存学会

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  • 日本再生歯科医学会   会長  

    2009   

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    Committee type:Academic society

    日本再生歯科医学会

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  • 国際歯科研究学会(International Association of Dental Research)   一般会員  

    2009   

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    Committee type:Academic society

    国際歯科研究学会(International Association of Dental Research)

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  • 日本歯科保存学会   理事  

    2009   

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    Committee type:Academic society

    日本歯科保存学会

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  • 日本歯科理工学会   評議員  

    2009   

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    Committee type:Academic society

    日本歯科理工学会

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  • 岡山歯学会   理事  

    2009   

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    Committee type:Academic society

    岡山歯学会

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  • 日本再生歯科医学会   学会長  

    2008   

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    Committee type:Academic society

    日本再生歯科医学会

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  • 日本歯科理工学会   評議員  

       

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    Committee type:Academic society

    日本歯科理工学会

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  • 日本歯科保存学会   理事  

       

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    Committee type:Academic society

    日本歯科保存学会

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  • 岡山歯学会   理事  

       

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    Committee type:Academic society

    岡山歯学会

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  • 硬組織生物学会   理事  

       

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    Committee type:Academic society

    硬組織生物学会

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  • 日本再生歯科医学会   会長  

       

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    Committee type:Academic society

    日本再生歯科医学会

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  • 日本バイオマリテリアル学会   評議員  

       

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    Committee type:Academic society

    日本バイオマリテリアル学会

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  • 接着歯学会   理事  

       

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    Committee type:Academic society

    接着歯学会

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Papers

  • Cavity adaptation of composite restorations prepared at crown and root: Optical assessment using OCT Reviewed International coauthorship

    RZ. Shahni, Y. Shimada, J. Tagami, M. Yoshiyama, A. Sadr

    Dental Materials Journal   38 ( 5 )   779 - 789   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

  • 漂白歯変化のSS-OCT評価 Reviewed International coauthorship

    神農泰生、島田康史、松崎久美子、横山章人、田上順次、吉山昌宏

    日本歯科保存学雑誌   64 ( 4 )   265 - 270   2021.8

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    Authorship:Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Assessment of Demineralization Inhibition Effects of Dentin Desensitizers Using Swept-Source Optical Coherence Tomography. International journal

    Kumiko Matsuzaki, Yasushi Shimada, Yasuo Shinno, Serina Ono, Kozo Yamaji, Naoko Ohara, Alireza Sadr, Yasunori Sumi, Junji Tagami, Masahiro Yoshiyama

    Materials (Basel, Switzerland)   14 ( 8 )   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    The purpose of this study was to evaluate the mechanism of action and the inhibiting effects of two types of desensitizers against dentin demineralization using pre-demineralized hypersensitivity tooth model in vitro. In this study, we confirmed that a hypersensitivity tooth model from our preliminary experiment could be prepared by immersing dentin discs in an acetic acid-based solution with pH 5.0 for three days. Dentin discs with three days of demineralization were prepared and applied by one of the desensitizers containing calcium fluoro-alumino-silicate glass (Nanoseal, NS) or fluoro-zinc-silicate glass (Caredyne Shield, CS), followed by an additional three days of demineralization. Dentin discs for three days of demineralization (de3) and six days of demineralization (de6) without the desensitizers were also prepared. The dentin discs after the experimental protocol were scanned using swept-source optical coherence tomography (SS-OCT) to image the cross-sectional (2D) view of the samples and evaluate the SS-OCT signal. The signal intensity profiles of SS-OCT from the region of interest of 300, 500, and 700 µm in depth were obtained to calculate the integrated signal intensity and signal attenuation coefficient. The morphological differences and remaining chemical elements of the dentin discs were also analyzed using scanning electron microscopy and energy-dispersive X-ray spectroscopy. SS-OCT images of CS and NS groups showed no obvious differences between the groups. However, SS-OCT signal profiles for both the CS and NS groups showed smaller attenuation coefficients and larger integrated signal intensities than those of the de6 group. Reactional deposits of the desensitizers even after the additional three days of demineralization were observed on the dentin surface in NS group, whereas remnants containing Zn were detected within the dentinal tubules in CS group. Consequently, both CS and NS groups showed inhibition effects against the additional three days of demineralization in this study. Our findings demonstrate that SS-OCT signal analysis can be used to monitor the dentin demineralization and inhibition effects of desensitizers against dentin demineralization in vitro.

    DOI: 10.3390/ma14081876

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  • Effect og gelatin hydrogel containing BMP-2 on bone formation in aged rats Reviewed

    K. Yamaji, A. Yokoyama, K. Matsuzaki, N. Ohara, M. Yoshiyama

    19 ( 1 )   10 - 14   2021.4

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  • Diagnosis of occlusal tooth wear using 3D imaging of OCT ex vivo Reviewed International coauthorship

    Sensors   20 ( 6016 )   6016-1 - 6016-14   2020.12

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    DOI: 10.3390//s20216016

  • 3D imaging of proximal caries in posterior teeth using OCT Reviewed International coauthorship

    Y. Shimada, J. Tagami, M. Yoshiyama, A. Sadr

    Scientific reports   10 ( 15754 )   15754-1 - 15754-10   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-020-7

  • Influence of 10-MDP on the adhesion and physical properties of self-adhesive resin cements Reviewed

    Restorative Dentistry & Endodontics   44 ( 4 )   e45 - e45   2020.10

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.5395/rde.2019.44.

  • 頭頸部癌患者に対する強度変調放射線治療中の体重減少に関する検討 Reviewed

    松崎秀信、松崎久美子、吉山昌宏他

    頭頸部癌   46 ( 3 )   264 - 269   2020.10

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  • 乾燥が成形修復材料の質量および曲げ強度に及ぼす影響 Reviewed

    渋谷和彦、大原直子、吉山昌宏他

    日本歯科保存学雑誌   63 ( 2 )   199 - 206   2020.9

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  • Color Matching Evaluation Using the Visual Analog Scale

    Serina ONO, Masahiro YOSHIYAMA, Naoko OHARA, Kumiko MATSUZAKI, Kazuhiko SHIBUYA, Akihito YOKOYAMA, Kei TAKAHASHI, Yasuo SHINNO, Kozo YAMAJI, Yasushi SHIMADA

    The Japanese Journal of Conservative Dentistry   63 ( 1 )   30 - 37   2020

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    Language:Japanese   Publisher:The Japanese Society of Conservative Dentistry  

    <p> Purpose: Recently, the application of composite resin restorations has expanded. Although chromatic studies of composite resins have progressed, color differences measured by colorimeters and visual color evaluation do not always match. The aim of this study was to establish a method of evaluating the visual color of composite resins by using the visual analog scale (VAS), which evaluates subjective data as a continuous variable, and to examine its validity.</p><p> Method: One structural color composite resin (experimental resin : ECM-001) and three commercial composite resins of shade A3 were used in this study. Class Ⅴ and class Ⅲ cavities were prepared in artificial maxillary central incisors of four shades (A1, A2, A3, and A3.5) and each composite resin was filled and its color matching was evaluated on a black-and-white background using VAS. The correlation between VAS value and visual evaluation was analyzed. The color matching of teeth and composite resin were statistically analyzed using one-way analysis of variance and Tukey's HSD test (p<0.05). Background differences in the same sample were analyzed by the <i>t</i>-test (p<0.05).</p><p> Results: In the Class Ⅴ restoration, ECM-001 showed better color matching than other composite resins. In the Class Ⅲ restoration, ECM-001 showed excellent color matching with a wide range of teeth shades on the white background. The VAS values of the other composite resins were higher on the black background than on the white background. However, the VAS value of ECM-001 on the black background tended to decrease. Because the evaluation of VAS color matching by evaluators showed the same tendency, the VAS value reflects information that can be recognized by visual observation. It is suggested that the evaluation of VAS value correlates with visual evaluation.</p><p> Conclusion: It is suggested that the evaluation of color matching of composite resin restorations using VAS is useful for structural color composite resins, providing a new method of visually evaluating composite resin restorations.</p>

    DOI: 10.11471/shikahozon.63.30

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  • Influence of 10-MDP concentration on the adhesion and physical properties of self-adhesive resin cements. International journal

    Kazuhiko Shibuya, Naoko Ohara, Serina Ono, Kumiko Matsuzaki, Masahiro Yoshiyama

    Restorative dentistry & endodontics   44 ( 4 )   e45   2019.11

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    Objectives: Self-adhesive resin cements contain functional monomers that enable them to adhere to the tooth structure without a separate adhesive or etchant. One of the most stable functional monomers used for chemical bonding to calcium in hydroxyapatite is 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP). The aim of this study was to evaluate the influence of the10-MDP concentration on the bond strength and physical properties of self-adhesive resin cements. Materials and Methods: We used experimental resin cements containing 3 different concentrations of 10-MDP: 3.3 wt% (RC1), 6.6 wt% (RC2), or 9.9 wt% (RC3). The micro-tensile bond strength of each resin cement to dentin and a hybrid resin block (Estenia C&B, Kuraray Noritake Dental) was measured, and the fractured surface morphology was analyzed. Further, the flexural strength of the resin cements was measured using the three-point bending test. The water sorption and solubility of the cements following 30 days of immersion in water were measured. Results: The bond strength of RC2 was significantly higher than that of RC1. There was no significant difference between the bond strength of RC2 and that of RC3. The water sorption of RC3 was higher than that of any other cement. There were no significant differences in the three-point bending strength or water solubility among all three types of cements. Conclusions: Within the limitations of this study, it is suggested that 6.6 wt% 10-MDP showed superior properties than 3.3 wt% or 9.9 wt% 10-MDP in self-adhesive resin cement.

    DOI: 10.5395/rde.2019.44.e45

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  • The effect of flowable composite lining and dentin location on microtensile bond strength and internal fracture formation Reviewed International coauthorship

    N. Kominami, Y. Shimada, J. Tagami, M. Yoshiyama, A. Sadr

    38 ( 5 )   798 - 805   2019.10

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  • 亜鉛ガラス含有グラスアイオノマーセメントによる根面脱灰抑制効果の検討 Reviewed

    高橋圭、島田康史、田上順次、吉山昌宏

    日本歯科保存学雑誌   62 ( 4 )   190 - 198   2019.8

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  • 透明根管模型歯における根管充填の評価法に関する検討

    松崎 久美子, 大原 直子, 澁谷 和彦, 横山 章人, 岡田 俊輔, 村上 純, 久富 美紀, 浅海 淳一, 吉山 昌宏

    岡山歯学会雑誌   38 ( 1 )   11 - 18   2019.6

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    Language:Japanese   Publisher:岡山歯学会  

    歯学部学生の臨床前基礎実習において透明根管模型歯は、全ての学生が同一条件下で実習を行えることや、根管治療における各ステップを目視できる等の利点がある。今回、本学歯学部4年次生47名が象牙質歯髄複合体診断・治療学実習の実技試験で根管充填を行った透明根管模型歯について、視診による評価と、デジタルX線画像のモニタ上での視診による評価、およびデジタルX線画像を画像解析ソフト(ImageJ)により解析した評価を行い、各評価法の妥当性について比較検討した。その結果、画像解析ソフトで解析する方法は成績の過小評価を防ぐうえで有用であり、より客観的な評価が可能と考えられた。

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  • Effect of direct pulp capping on hard tissue formation by using alginate gel containing bone morphogenic protein-2 Reviewed

    A. Yokoyama, K. Yamaji, K. Matsuzaki, N. Ohara, M. Yoshiyama

    17 ( 2 )   53 - 58   2019.4

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  • Three dimensional assessment of proximal contact enamel using optical coherence tomography Reviewed International coauthorship

    TZ. Ei, Y. Shimada, J. Tagami, M. Yoshiyama, A. Sadr

    Dental materials   35 ( 1 )   e74 - e82   2019.1

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  • ヒドロキシアパタイトを含む実験的接着剤を用いた長期間の樹脂のミネラル化(Mineralization of Resin Using Experimental Adhesives Containing Hydroxyapatite in Long Term)

    Hoshika Tomohiro, Nishitani Yoshihiro, Takahashi Kei, Ogata Haruka, Ohara Naoko, Kajihara Takehiro, Yoshiyama Masahiro

    Journal of Oral Tissue Engineering   13 ( 2 )   85 - 95   2015.12

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    Language:English   Publisher:日本再生歯科医学会  

    酸腐食象牙質への樹脂の浸透が不完全な場合は、ハイブリッド層に水分の多い、樹脂の少ない領域(隙間)が残ってしまい、樹脂や微細繊維の分解を引き起こすと推測される。実験的樹脂にヒドロキシアパタイト(Hap)を加えると、微小隙間をリン酸カルシウムで満すことができると考え、その仮説について検証した。0、5、10wt%のHApを加えた樹脂を作成した。この樹脂について、水分吸着と可溶性評価、カルシウム沈着誘導の評価、走査型電子顕微鏡観察とエネルギー分散X線分析、引張り試験を行った。その結果、HApは象牙質への樹脂の浸透には効果がなかったが、歯科用接着剤にHApを添加するとハイブリッド層の下に結晶を形成させ、強いアンカーになることが示唆された。

    DOI: 10.11223/jarde.13.85

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  • Effects of quaternary ammonium-methacrylates on the mechanical properties of unfilled resins. Reviewed

    Hoshika T, Nishitani Y, Yoshiyama M, Key WO, Brantley W, Agee KA, Breschi L, Cadenaro M, Tay FR, Rueggeberg F, Pashley DH

    Dental materials : official publication of the Academy of Dental Materials   30 ( 11 )   1213 - 1223   2014.11

  • ヒト骨髄間葉系幹細胞からのES細胞の誘導 細胞のエピジェネティック制御および初期化(Induction of ES cells from Human Bone Marrow Mesenchymal Stem Cells: Epigenetic Control and Initialization of the Cells)

    Izawa Shunji, Yamaji Kozo, Hoshika Tomohiro, Nishitani Yoshihiro, Yoshiyama Masahiro

    Journal of Oral Tissue Engineering   11 ( 3 )   220 - 226   2014.3

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    細胞の初期化と密接に関連するエピジェネティック制御に焦点をあて、腫瘍壊死因子(TNF)-αおよびアクチビンAの転写因子セットを用いてエピジェネティック制御の初期化マーカーであるOct4の発現レベルを検討した。自然治癒、免疫反応、再生力の活性化因子としてTNF-αおよび環境因子としてアクチビンAのサイトカインセットを含む培地(試験群)、TNF-αのみを含む培地、アクチビンAのみを含む培地、どちらも含まない培地でヒト間葉系幹細胞(hMSC)を培養し、Oct4およびSox2のmRNA発現を評価した。細胞の初期化を示すOct4のmRNAは試験群で経時的に増大したが、Sox2のmRNAは全培地で著しく減少した。ES細胞初期化の典型的マーカーであるアルカリホスファターゼ活性が試験群において3週間後に検出された。以上から、TNF-αおよびアクチビンAの転写因子セットは、ES様細胞へのhMSCの初期化を誘導することが示唆された。

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  • 接着技法を応用した破折歯の治療術式の検討 Invited Reviewed

    吉山 昌宏, 小田 豊, 山本 一世, 今里 聡, 中村 洋, 川浪 雅光, 菅谷 勉, 林 美加子, 西谷 佳浩

    日本歯科医学会誌   33   69 - 73   2014

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  • セルフアドヘッシヴ・レジンセメントのサーマルサイクル負荷後のジルコニアに対する接着強さと曲げ特性

    入江 正郎, 田仲 持郎, 松本 卓也, 長岡 紀幸, 丸尾 幸憲, 西川 悟郎, 吉山 昌宏

    接着歯学   31 ( 3 )   139 - 139   2013.11

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  • Effects of chlorhexidine in self-etching adhesive: 24 hours results. Reviewed

    Nishitani Y, Hosaka K, Hoshika T, Yoshiyama M, Pashley DH

    Dental materials journal   32 ( 3 )   420 - 424   2013

  • 新しい多用途型処理材の接着強さからの検討

    入江 正郎, 田仲 持郎, 松本 卓也, 玉田 宜之, 丸尾 幸憲, 西川 悟郎, 吉山 昌宏

    接着歯学   30 ( 3 )   126 - 126   2012.11

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  • Adhesive properties of newly bonding resin Absolute 3

    Morimoto Sayako, Nishitani Yoshihiro, Hoshika Tomohiro, Yamaji Kozo, Yoshiyama Masahiro

    Abstracts of the General Sessions of the Japanese Society for Dental Materials and Devices   2009 ( 0 )   72 - 72   2009

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    Language:Japanese   Publisher:The Japanese Society for Dental Materials and Devices  

    The purpose of this study was to evaluate the properties of Absolute2 and Absolute3.We made specimens to measure micro-tensile bond strengths (MTBS) and observe morphological structure by scanning electron microscopy with Absolute2 and Absolute3. Moreover, specimens bonded to dry enamel and dentin surface were made additionally.MTBS of Absolute3 was higher than those of Absolute2 or Absolute3 bonded to dry tooth surface. It was indicated that the property of Absolute3 was equivalent or superior compared to that of Absolute2.

    DOI: 10.14832/gsjsdmd.2009f.0.72.0

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  • ブリーチング後のエナメル質の微小硬度および表面粗さの変化に関する研究

    大前正範, 山田敦子, 岸本麻実, 穴吹優佳, 高橋圭, 西谷佳浩, 吉山昌宏

    歯科審美   21 ( 1 )   6 - 11   2008

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  • ホワイトニングのコンポジットレジンの表面性状に与える影響

    山田敦子, 大前正範, 岸本麻実, 穴吹優佳, 高橋圭, 西谷佳浩, 吉山昌宏

    歯科審美   21 ( 1 )   12 - 19   2008

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  • Water sorption and solubility of methacrylate resin - based root canal sealers Reviewed

    Donnelly Adam, Sword Jeremy, Nishitani Yoshihiro, Yoshiyama Masahiro, Agee Kelli, Tay Franklin R, Pashley David H

    JOURNAL OF ENDODONTICS   33 ( 8 )   990 - 994   2007.8

  • Bond strength of one step bonding systems to artificial demineralized root dentin

    Doi Junichi, Omae Masanori, Yamaji Kozo, Nishitani Yoshihiro, Yoshiyama Masahiro

    Abstracts of the General Sessions of the Japanese Society for Dental Materials and Devices   2007 ( 0 )   146 - 146   2007

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    Language:Japanese   Publisher:The Japanese Society for Dental Materials and Devices  

    DOI: 10.14832/gsjsdmd.2007s.0.146.0

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  • Bone formation induced by combined recombinant human BMP-2 and atero collagen sponge in vivo

    Yamaji Kozo, Itota Toshiyuki, Doi Junichi, Tashiro Yoko, Omae Masanori, Nishitani Yoshihiro, Yoshiyama Masahiro

    Abstracts of the General Sessions of the Japanese Society for Dental Materials and Devices   2006 ( 0 )   101 - 101   2006

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    Publisher:The Japanese Society for Dental Materials and Devices  

    DOI: 10.14832/gsjsdmd.2006s.0.101.0

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  • Effects of water sorption on modulus of elasticity of unfilled dental resins Reviewed

    S.Ito, T.Saito, K.Endo, H.Ohno, M.Hashimoto, M.Yoshiyama, FR.Tay, DH.Pashley

    Achieves of Bioceramics Research   5   412 - 415   2005

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  • rhBMP-2誘導性硬組織形成に対するphosphophorynの影響

    斎藤 隆史, 小林 文人, 吉山 昌宏, 別所 和久

    日本再生歯科医学会誌   1 ( 1 )   70 - 70   2003.12

  • Effect of remineralization-accelerating agent on dentin bonding Reviewed

    Y Nishitani, T Yamada, S Nakabo, T Itota, M Yoshiyama

    DENTIN/PULP COMPLEX   132 - 134   2002

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    Language:English   Publishing type:Research paper (international conference proceedings)   Publisher:QUINTESSENCE PUBLISHING CO INC  

    Resent in vivo dentin bonding studies revealed that hybrid layers might be degraded by hydrolysis of adhesive resins and hydrolytic attack of collagen fibrils. A remineralization-accelerating agent (RE-01) has been developed by GC, and application of RE-01 to dentin surfaces can form fluorapatite on the surfaces instantly. If hybrid layers include fluorapatite during dentin bonding, it is possible to increase the longevity of hybrid layers in vivo. To evaluate the possibility of RE-01 as pretreatment for bonding, we have measured the microtensile bond strengths of an adhesive system (Unifil Bond) to RE-01-applied human dentin. Intact extracted human teeth were used, and sound ground dentin surfaces were prepared on coronal dentin. RE-01 was applied on the surfaces, and Unifil Bond was bonded to the pretreated surfaces. After composite buildup, the specimens were subjected to microtensile bond strength testing and scanning electron microscopy (SEM). The bond strength of Unifil Bond to untreated dentin was 32.0 +/- 5.35 MPa, but that to RE-01-treated dentin was 20.5 +/- 7.09 MPa. There was a significant difference between the values (P&lt;0.05, t-test). SEM observation revealed that RE-01 could form fluorapatite crystals on the surfaces, and these crystals could be incorporated into the hybrid layers. These results suggest that pretreatment with RE-01 might contribute to the longevity of dentin bonding.

    Web of Science

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  • Abnormal dentin as a bonding substrate: Resin adhesion to carious and sclerotic dentin Reviewed

    M Yoshiyama, Y Nishitani, T Yamada, J Doi, T Itota, FR Tay, RM Carvalho, DH Pashley

    DENTIN/PULP COMPLEX   71 - 77   2002

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    Language:English   Publishing type:Research paper (international conference proceedings)   Publisher:QUINTESSENCE PUBLISHING CO INC  

    Almost all adhesive bonding studies are done on normal dentin rather than on clinically relevant substrates such as caries-affected dentin or sclerotic cervical root dentin.
    Recently, a new bond-testing procedure has been developed which permits the measurement of small (ca. 1mm(2)) cross-sectional bonded area. It has been called the microtensile bond strength test (MTBS), and the bond strengths of current bonding systems to normal versus caries-affected dentin could be measured. Moreover, we could clarify the adhesive property of current resin systems to cervical sclerotic dentin. Recently, we reported the bond strengths of current bonding, systems to caries-infected dentin, and observed the interfacial morphology of resin-bonded caries-infected dentin by a transmission electron microscopy (TEM). These results suggested that even caries-infected dentin could be considered a. substrate for resin bonding, and that bonding agents can embed carious bacteria within the denatured dentin matrix. However, to establish the new caries treatment method named as modified sealed restoration (MSR), bonding to caries-infected dentin should be improved.

    Web of Science

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  • Distribution of calbindin D-28k and osteonectin in human carious teeth Reviewed

    T Itota, Y Nishitani, Y Tashiro, S Nakabo, T Takatsuka, N Konishi, Y Torii, M Yoshiyama

    DENTIN/PULP COMPLEX   110 - 112   2002

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    Language:English   Publishing type:Research paper (international conference proceedings)   Publisher:QUINTESSENCE PUBLISHING CO INC  

    Immunolocalizations of calbindin D-28k (CB) and osteonectin (ON) in human carious teeth were studied by using an indirect immunofluorescence method. Carious teeth were decalcified and cryostat sections were prepared for immunofluorescence staining. Sections were incubated with anti-CB antibody and anti-ON antibody, followed by the incubation with tetramethyl rhodamine-conjugated swine anti-rabbit IgG and FITC-conjugated donkey anti-mouse IgG. They were examined under a confocal laser scanning microscope. The sections were then stained with hematoxylin-eosin. In hematoxylin-eosin stain, tertiary dentin with the tubule-poor pattern was observed underneath carious lesion, and this dentin was eosinophilic. Beneath this dentin, odontoblasts usually lacked CB immunoreactivity, whereas ones underneath the secondary dentin in carious teeth showed the immunoreactivity. ON immunoreactivity was detected in odontoblasts and dentin in carious teeth. Odontoblasts beneath the tertiary dentin, however, showed the weak ON immunoreactivity regardless of the moderate immunoreactivity in odontoblasts underneath the secondary dentin. The tertiary dentin also showed the thin ON immunoreactivity regardless of the moderate immunoreactivity in primary and secondary dentin. In conclusion, it was demonstrated that the expressions of CB and ON immunoreactivities in odontoblasts and dentin underneath carious lesion were different from those underneath the portion without carious lesion in carious teeth. These findings may suggest that the odontoblasts underneath carious lesion became inactively after the formation of tertiary dentin.

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  • Tensile bond strength and SEM evaluation of caries-affected dentin using dentin adhesives.(共著)

    Nakajima M, Sano H, Burrow MF, Tagami J, Yoshiyama M, Ebisu S, Ciucchi B, Russell CM, Pashley DH

    Journal of Dental Research   74 ( 10 )   1679 - 1688   1995

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  • 歯根部の象牙質齲蝕病巣における侵入細菌の局在性に関する免疫組織学的研究 Reviewed

    尾崎和美, 松尾敬志, 中江英明, 野杁由一郎, 大木元玲子, 吉山昌宏, 恵比須繁之

    日本歯科保存学雑誌   36 ( 5 )   1284 - 1291   1993.10

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    Language:Japanese  

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  • 小窩裂溝部および平滑面部の象牙質齲蝕病巣における侵入細菌の局在性に関する免疫組織学的研究 Reviewed

    尾崎和美, 松尾敬志, 中江英明, 野杁由一郎, 大木元玲子, 吉山昌宏, 恵比須繁之

    日本歯科保存学雑誌   36 ( 4 )   1059 - 1069   1993.8

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    Language:Japanese   Publisher:(NPO)日本歯科保存学会  

    1)Smは小窩裂溝および平滑面齲蝕の全てで検出され,またその細菌侵入率も齲蝕の表層および中層で他の細菌種に比して著明に高かった。2)SSは,Smに次ぐ細菌検出率を示したが,その侵入率はSmよりかなり低かった。3)Av,Lc,Lpおよび偏性嫌気性細菌のPm,Ea,Paは,比較的高い細菌検出率だが,その侵入率はSmに比して有意に低い値を示した。4)Sa,Fn,Peは細菌検出率,細菌侵入率とも著明に低い値を示した

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Books

  • 保存修復学21第6版 Reviewed

    吉山昌宏( Role: Joint author ,  レジン充填)

    永末書店  2021.12 

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    Total pages:350   Responsible for pages:160-170   Language:Japanese

  • 保存修復学第7版 Reviewed

    吉山昌宏( Role: Joint author ,  コンポジットレジンインレー)

    医歯薬出版  2019.9 

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    Total pages:300   Responsible for pages:297-211   Language:Japanese Book type:Textbook, survey, introduction

  • 保存修復学21第5版

    永末書店  2017 

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  • 口腔組織・発生学第2版

    医歯薬出版  2015 

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  • 保存修復学第6版

    医歯薬出版  2013 

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  • 力を診る(歯列を守る力のマネジメント)

    医歯薬出版  2012 

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  • 雑学読本 NHK ためしてガッテン15

    NHK出版  2011  ( ISBN:9784140113066

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  • 保存修復21

    永末書店  2011  ( ISBN:9784816012211

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  • Oral clinic companion for dentists

    Kinbara publishing company  2010  ( ISBN:9784307450119

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  • Drugs '10/'11 Dental medication

    Quintessence publishing company  2010  ( ISBN:9784781201634

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  • 医師・歯科医師のための口腔診療必携

    金原出版株式会社  2010  ( ISBN:9784307450119

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  • 薬 '10/'11 歯科疾患名から治療薬と処方例がすぐわかる本

    クインテッセンス出版株式会社  2010  ( ISBN:9784781201634

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  • MI時代の歯科組織―プラークコントロール サイエンス&プラクティス

    永末書店  2009 

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  • 保存修復学専門用語集

    医歯薬出版  2009 

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  • 保存修復学専門用語集

    医歯薬出版  2009 

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  • 保存修復学専門用語集

    医歯薬出版  2009 

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  • MI時代の歯科組織―プラークコントロール サイエンス&プラクティス

    永末書店  2009 

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  • 接着ここが知りたい-歯科技工士編

    口腔保健協会  2008 

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  • 現代の治療指針 保存・審美修復&カリオロジーと全治療分野編

    クインテッセンス出版,東京  2007 

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  • 現代の治療指針 保存・審美修復&カリオロジーと全治療分野編

    クインテッセンス出版,東京  2007 

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  • 歯科臨床研修マニュアル アドバンス編 --ひとつ上をめざす研修医のために--

    永末書店,京都  2007 

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  • 歯科臨床研修マニュアル アドバンス編 --ひとつ上をめざす研修医のために--

    永末書店,京都  2007 

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  • 保存修復学第5版

    医歯薬出版,東京  2007 

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  • 目的別PMTCとオーラルケア

    クインテッセンス出版,東京  2006 

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  • 歯科薬理学、第5版

    医歯薬出版  2005 

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  • う蝕治療のミニマルインターベンション

    クインテッセンス出版,東京  2004 

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  • う蝕治療のミニマルインターベンション

    クインテッセンス出版,東京  2004 

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  • 現代の治療指針 全治療分野とカリオロジー

    クインテッセンス,Tokyo  2003 

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  • Proceeding of the international symposium '01 in Tokyo

    Kuraray medical,Tokyo  2003 

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  • Giomer international meeting/Japan proceedings

    Shofu,Kyoto  2003 

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  • 現代の治療指針 全治療分野とカリオロジー

    クインテッセンス,Tokyo  2003 

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  • Modern Trends in Adhesive Dentistry Proceedings of the Adhesive Dentistry Forum 2001 in Okayama, Japan

    Kuraray Medical Inc.  2002 

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  • 保存修復学 21

    永末書店,東京  2002 

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  • 接着歯学 minimal Interventionを求めて

    医歯薬出版,東京  2002 

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  • Proceedings of the International Conference on Dentin/Pulp Complex 2001

    Quintessence publishing,Tokyo  2002 

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  • Proceedings of the International Conference on Dentin/Pulp Complex 2001

    Quintessence publishing,Tokyo  2002 

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  • Modern trends in adhesive dentistry processings of the adhesive dentistry forum 2001 in okayama japan

    Kuraray Medical ,Tokyo  2002 

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  • Modern trends in adhesive dentistry processings of the adhesive dentistry forum 2001 in okayama japan

    Kuraray Medical ,Tokyo  2002 

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  • Modern Trends in Adhesive Dentistry Proceedings of the Adhesive Dentistry Forum 2001 in Okayama, Japan

    Kuraray Medical Inc.  2002 

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  • Modern trends in adhesive dentistry processings of the adhesive dentistry forum 2001 in okayama japan

    Kuraray Medical ,Tokyo  2002 

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  • Modern Trends in Adhesive Dentistry Proceedings of the Adhesive Dentistry Forum 2001 in Okayama

    Kuraray Medical ,Tokyo  2002 

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  • Modern Trends in Adhesive Dentistry Proceedings of the Adhesive Dentistry Forum 2001 in Okayama, Japan

    Kuraray Medical Inc.  2002 

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  • Caries Preventive Restoration

    GC Co.  2001 

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  • Caries Preventive Restoration

    GC Co.  2001 

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  • Caries Preventive Restoration

    GC Co.  2001 

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  • Advanced adhesive dentistry 3rd international kuraray symposium

    Kuraray Co. Ltd  2000 

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  • 新保存修復学 (共著)

    クインテッセンス出版 

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  • 接着歯学

    医歯薬出版 

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  • 歯科薬理学(第4版)

    医歯薬出版株式会社 

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MISC

  • Influence of dentin desensitizer on bond strength of self-etching adhesive system

    K. Tanaka, M. Yoshiyama

    Japanese journal of conservative dentistry   60 ( 1 )   22 - 31   2017

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  • MTAの剪断接着強さに対する接着材料の影響

    吉山昌宏

    ザ・クインテッセンス   36 ( 3 )   196 - 197   2017

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  • 象牙質知覚過敏抑制材がセルフエッチング接着システムの接着強さに及ぼす影響

    松崎ー田中久美子, 吉山昌宏

    日本歯科保存学   60 ( 1 )   22 - 31   2017

  • Treatment of root caries for super aging

    M. Yoshiyama

    1252 ( 12 )   42 - 44   2017

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  • Treatment of root caries for super aging

    M. Yoshiyama

    1251 ( 11 )   45 - 48   2017

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  • Treatment of root caries for super aging

    M. Yoshiyama

    The Quintessence   36 ( 9 )   66 - 73   2017

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  • 超高齢社会における歯科の緊急課題ー根面う蝕への対応(2)

    吉山昌宏

    月刊保団連   1252 ( 12 )   42 - 44   2017

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  • 超高齢社会における歯科の緊急課題ー根面う蝕への対応

    吉山昌宏

    月刊保団連   1251 ( 11 )   45 - 48   2017

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  • 超高齢社会を見据えた根面う蝕と知覚過敏への対応

    吉山昌宏

    ザ   36 ( 9 )   66 - 73   2017

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  • 各種象牙質知覚過敏抑制材の象牙細管封鎖性について

    清水裕久, 吉山昌宏他

    日本歯科保存学雑誌   59 ( 3 )   249 - 258   2016

  • Effects of Aging on Bone Formation Induced by BMP-2 using Low-intensity Pulsed Ultrasound

    YAMAJI Kozo, YOKOYAMA Akihito, MATSUZAKI Kumiko, OHARA Naoko, NISHIYAMA Eriko, SUGAYA Tsutomu, YOSHIYAMA Masahiro

    Journal of Oral Tissue Engineering   14 ( 1 )   65 - 69   2016

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    Language:English   Publisher:Japanese Association of Regenerative Dentistry  

    <p>The purpose of this study was to evaluate the effects of aging on bone formation induced by Bone Morphogenetic Protein-2 (BMP-2) using low-intensity pulsed ultrasound (LIPUS)in 12-week-old (12w group) and 70-week-old (70w group) Wistar rats.</p><p>The experimental sites (palatal subperiosteal sites) were divided into three sites as follows: BMP site, BMP-2 was implanted; LI-BMP site, LIPUS treatment was performed every three days after implantation of BMP-2; and Control site, neither implantation of BMP-2 nor LIPUS treatment was done.</p><p>At 3 weeks after surgery, thickness of new bone (TNB) was significantly higher in both the BMP and LI-BMP sites than in the Control site (P<0.05). TNB of every site in the 12w group was significantly higher than that of the same experimental site in the 70w group (P<0.05). Newly formed bone was almost integrated with original bone at the LI-BMP site.</p><p>These results suggest that LIPUS enhances the maturation of bone formation induced by BMP-2 even in senescent rats, although the volume of bone decreased with aging.</p>

    DOI: 10.11223/jarde.14.65

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  • Study of Pluripotency and Activation of Totipotency in Human Adipose-derived Stem Cells

    IZAWA Shunji, YAMAJI Kozo, YOKOYAMA Akihito, MATSUZAKI Kumiko, OHARA Naoko, YOSHIYAMA Masahiro

    Journal of Oral Tissue Engineering   13 ( 3 )   131 - 135   2016

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    Language:English   Publisher:Japanese Association of Regenerative Dentistry  

    Tissue regeneration is the important issue in the field of operative dentistry. In the previous study, we demonstrated that TNFα activates the potential for totipotency in human bone marrow mesenchymal stem cells (hMSCs) and leads to the regeneration of target cells or tissues along with the appropriate differentiating factor such as Emd-Gel. In this study, we apply the transcription factor set of TNF-α and Amelogenin to the human adipose-derived stem cells (hASCs) and our results indicate that this transcription factor set differentiate hASCs into odontblasts simillary and suggest that TNFα activates potential totipotency of hASCs and the activation can lead to the regeneration of target cells or tissues

    DOI: 10.11223/jarde.13.131

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  • 一液性処理材の歯質接着強さ 処理時間の影響

    入江 正郎, 田仲 持郎, 松本 卓也, 武田 宏明, 鳥井 康弘, 吉山 昌宏, 吉原 久美子

    特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集   142回   110 - 110   2015.6

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  • 象牙質知覚過敏抑制材塗布がレジン接着強さに及ぼす影響

    高橋圭, 吉山昌宏他

    接着歯学   33 ( 4 )   163 - 169   2015

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  • フッ化ナトリウムの配合が接着性レジンセメントの曲げ強さと吸水および溶解に及ぼす影響

    大原直子, 吉山昌宏他

    日本歯科保存学会誌   58 ( 1 )   10 - 16   2015

  • セルフアドヘッシブ・レジンセメントの劣化加速試験後の機械的特性

    入江 正郎, 田仲 持郎, 松本 卓也, 長岡 紀幸, 丸尾 幸憲, 西川 悟郎, 皆木 省吾, 吉山 昌宏

    接着歯学   32 ( 3 )   166 - 166   2014.11

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    Language:Japanese   Publisher:(一社)日本接着歯学会  

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  • 垂直歯根破折歯を口腔外接着再植法にて保存した症例

    大原直子, 吉山昌宏他

    岡山歯学会雑誌   33 ( 1 )   7 - 10   2014

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  • Tooth Wearに対してコンポジットレジンによる審美修復を行った症例

    田中久美子, 西谷佳浩, 大原直子, 吉山昌宏他

    岡山歯学会   33 ( 1 )   1 - 5   2014

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  • コンポジットレジン修復の歯質接着強さの経時的推移

    入江正朗, 吉山昌宏他

    接着歯学   32 ( 1 )   8 - 13   2014

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  • IZ法による樹脂含浸層におけるMMP活性の解析

    吉山昌宏

    the Quintessence   32 ( 4 )   202 - 203   2013

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  • 合着用レジン添加型グラスアイオノマーセメントの種々の被着体への接着性と曲げ強度

    入江正郎他

    接着歯学   31 ( 2 )   45 - 52   2013

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  • A case of resin composite restoration using rubber dam for the patient with dysphagia in okayama university hospital head and neck cancer center

    K. Tanaka, M. Yoshiyama

    Okayama Dental Association Journal   32 ( 2 )   65 - 70   2013

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  • セルフアドヒーシブレジンセメントで合着された間接法MODコンポジットレジンインレーの接着

    大原直子, 吉山昌宏

    the Quintessence   32 ( 7 )   210 - 211   2013

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  • 知覚過敏抑制材:ティースメイト・ディセンシタイザー

    吉山昌宏

    デンタルマガジン   ( 144 )   1 - 4   2013

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  • レジン象牙質接着界面の観察

    田中久美子, 西谷佳浩, 大原直子, 吉山昌宏

    日本歯科保存学雑誌   56 ( 4 )   310 - 317   2013

  • 嚥下障害を有する岡山大学病院頭頸部がんセンターの患者に対して厳重なラバーダム装着がコンポジットレジン修復に有効であった症例

    田中久美子, 西谷佳浩, 大原直子, 吉山昌宏

    岡山歯学会雑誌   32 ( 2 )   65 - 70   2013

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  • rBMP-2を生体ラットに移植した場合の骨形成に対する低出力超音波パルスの影響

    山路公造他

    日本歯科保存学雑誌   56 ( 4 )   318 - 324   2013

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    Language:Japanese   Publisher:(NPO)日本歯科保存学会  

    目的:低出力超音波パルス(Low-intensity Pulsed Ultrasound,LIPUS)は,骨形成を促し治癒を促進させることが知られており,現在骨折の治療などに臨床応用されている.本研究は増殖因子であるリコンビナントヒトBMP-2(rhBMP-2)を成体ラットの口蓋部骨膜下に移植しLIPUS照射を施した場合,骨形成にどのような影響を及ぼすか検討する目的で行った.材料と方法:15週齢ウィスター系雄性ラットの口蓋粘膜を.離後,rhBMP-2を配合したポリ乳酸グリコール酸共重合体/ゼラチンスポンジ複合体(配合比1.0μg/μl)を移植し,LIPUSを照射した場合(LI-BMP群)と,照射しない場合(BMP群)のグループに分けた.また,何も移植せずにLIPUSを照射した場合(LI群)と,照射しない場合(Cont群)のグループに分けた.LIPUSの照射条件は1.0MHz,240mW,照射時間5分間とし,移植後から観察期間終了まで3日ごとに照射を行った.観察期間は3週間とした.成績:LI-BMP群とBMP群の新生骨は,LI群およびCont群と比べて有意に多かった(p<0.05).LI-BMP群とBMP群間には有意差は認められなかった(p>0.05).また,BMP群の新生骨は既存骨と明瞭な境界で接していたのに対して,LI-BMP群では緻密な構造を有し既存骨とほとんど一体化していた.結論:以上の結果,rhBMP-2を成体ラットの口蓋部骨膜下に移植した場合,低出力超音波パルスを照射することにより新生骨形成が促進され,早期に既存骨と一体化する可能性が示唆された.(著者抄録)

    DOI: 10.11471/shikahozon.56.318

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  • Bonding to NaOCl-treated Dentin: Effect of Pretreatment with Sodium Toluene Sulfinic Acid

    Xianghong Li, Weidong Ma, Xiaodong Chen, Jiaming Zhao, Takashi Nakata, Kumiko Tanaka, Kei Takahashi, Yoshihiro Nishitani, Masahiro Yoshiyama

    JOURNAL OF ADHESIVE DENTISTRY   14 ( 2 )   129 - 136   2012.4

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    Purpose: The use of sodium hypochlorite (NaOCl) can decrease the bond strength of 4-META/MMA-TBB resin cement to root dentin. The aim of this in vitro study was to evaluate the effect of sodium toluene sulfinic acid (SA) as a pretreatment to increase bond strength to NaOCl-treated dentin.
    Materials and Methods: The root canal dentin of bovine teeth was treated with 6 methods: group 10-3 (10% citric acid/3% ferric chloride; control); group SA; group NC (sodium hypochlorite/10-3 solution); group NS-10-3 (NaOCl + sulfinic acid + 10-3 solution); group HSA-10-3 (NaOCl + H2O2 + NaOCl + sulfinic acid + 10-3 solution); group H0-10-3 (NaOCl + H2O2 + NaOCl + 10-3 solution). The roots were then filled with Super-Bond C&B (SB) or Super-Bond sealer (SBS). Samples were stored in distilled water for 24 h at 37 degrees C and then cross sectioned into five slabs (0.8 mm thick) that were subjected to "trimming" microtensile bond strength testing. All treated dentin surfaces and resin/dentin bond interfaces were analyzed under SEM.
    Results: Compared with the control, NaOCl treatment significantly decreased the resin/dentin bond strengths. However, SA treatment following NaOCl irrigation resulted in no significant differences of bond strength values.
    Conclusion: Sulfinic acid was effective in restoring 4-META/MMA-TBB resin cement bond strength after NaOCl irrigation.

    DOI: 10.3290/j.jad.a22090

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  • Study of the dentin permeability of the dentin desensitizers

    SHIMIZU H, HOSHIKA T, NISHITANI Y, YOSHIYAMA M

    The journal of the Japanese Society for Dental Materials and Devices   31 ( 2 )   178 - 178   2012.3

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    Presently, many dentin desensitizers have already been applied in clinical situation. However, the sealing mechanism of dentin tubules by dentin desensitizers is not same. In this study, we pay attention to the difference of the sealing mechanism of dentin tubules by dentin desensitizers, and the products that have different sealing mechanisms of dentin tubules were applied to the dentin hypersensitive model that applied the hydrostatic pressure from the pulp chamber side to the dentin surface side, and evaluated the ratio of the dentin permeability from the movement of the water in dentin tubules before and after the dentin desensitizer application.

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  • Carbodiimide Cross-linking Inactivates Soluble and Matrix-bound MMPs, in vitro

    A. Tezvergil-Mutluay, M. M. Mutluay, K. A. Agee, R. Seseogullari-Dirihan, T. Hoshika, M. Cadenaro, L. Breschi, P. Vallittu, F. R. Tay, D. H. Pashley

    JOURNAL OF DENTAL RESEARCH   91 ( 2 )   192 - 196   2012.2

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    Matrix metalloproteinases (MMPs) cause collagen degradation in hybrid layers created by dentin adhesives. This in vitro study evaluated the feasibility of using a cross-linking agent, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), to inactivate soluble rhMMP-9, as an example of dentin MMPs, and matrix-bound dentin proteases. The inhibitory effects of 5 EDC concentrations (0.01-0.3 M) and 5 incubation times (1-30 min) on soluble rhMMP-9 were screened with an MMP assay kit. The same EDC concentrations were used to evaluate their inhibitory effects on endogenous proteinases from completely demineralized dentin beams that were incubated in simulated body fluid for 30 days. Decreases in modulus of elasticity (E) and dry mass of the beams, and increases in hydroxyproline content of hydrolysates derived from the incubation medium were used as indirect measures of matrix collagen hydrolysis. All EDC concentrations and pre-treatment times inactivated MMP-9 by 98% to 100% (p &lt; 0.05) compared with non-crosslinked controls. Dentin beams incubated in 0.3 M EDC showed only a 9% decrease in E (45% decrease in control), a 3.6% to 5% loss of dry mass (18% loss in control), and significantly less solubilized hydroxyproline when compared with the control without EDC cross-linking (p &lt; 0.05). It is concluded that EDC application for 1 min may be a clinically relevant and effective means for inactivating soluble rhMMP-9 and matrix-bound dentin proteinases if further studies demonstrate that EDC is not toxic to pulpal tissues.

    DOI: 10.1177/0022034511427705

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  • Study of Pluripotency and Activation of Totipotency in Human Bone Marrow Mesenchymal Stem Cell.

    Shunji IZAWA, Kozo Yamaji, Tomohiro Hoshika, Yoshihiro Nishitani, Masahiro Yoshiyama

    J Oral Tissue Engin   10 ( 2 )   95 - 103   2012

  • 合着用レジン添加型グラスアイオノマーセメントの歯質接着性と曲げ特性

    入江正郎, 松本卓也, 吉山昌宏

    日本接着歯学会   30 ( 4 )   137 - 144   2012

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  • Microtensile bond strength of self-adhesive luting cements to ceramics

    Tomoko Abo, Shigeru Uno, Masahiro Yoshiyama, Toshimoto Yamada, Nobuhiro Hanada

    International Journal of Dentistry   1 - 5   2012

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    The purpose of this paper was to compare the bond strengths of the self-adhesive luting cements between ceramics and resin cores and examine their relation to the cement thickness. Three self-adhesive luting cements (Smartcem, Maxcem, and G-CEM) and a resin cement (Panavia F 2.0) for control were used in the paper. The thickness of the cements was controlled in approximately 25, 50, 100, or μ200m. Each 10 specimens were made according to the manufacturers instructions and stored in water at 37C. After 24 hours, microtensile bond strength (μTBS) was measured. There were significant differences in cements. Three self-adhesive cements showed significantly lower TBSs than control that required both etching and priming before cementation (Tukey, P &lt
    0.05). The cement thickness of 50 or 100m tended to induce the highest TBSs for each self-adhesive luting cements though no difference was found. © Copyright 2012 Tomoko Abo et al.

    DOI: 10.1155/2012/278623

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  • う蝕除去法の異なる象牙質へのセルフエッチングシステムの接着.

    西谷佳浩, 糸田俊之, 星加知宏, 高橋圭, 田中久美子, 森本紗也子, 伊澤俊次, 山路公造, 鳥井康弘, 吉山昌宏

    日本歯科保存学雑誌   54 ( 4 )   276 - 288   2011

  • 楔状欠損と歯根露出による知覚過敏の発症原因とその対処法.

    吉山昌宏

    補綴臨床   44 ( 4 )   355 - 365   2011

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  • 潜在疾患tooth wear 患者啓発と指導.

    吉山昌宏

    DENTAL Press ADVANCE   3   0-0   2011

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  • 岡山大学病院 審美歯科外来.

    伊澤俊次, 神農泰生, 山路公造, 西谷佳浩, 吉山昌宏

    審美歯科   23 ( 2 )   5 - 15   2011

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  • 根管治療を行った大臼歯におけるコンポジットレジンとポーセレンCAD/CAMオーバーレイ修復の疲労抵抗性試験.

    大原直子, 吉山昌宏

    The Quintessence   30 ( 3 )   130 - 137   2011

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  • 知覚過敏症のメカニズムと対処法

    吉山昌宏

    GCサークル   13 ( 8 )   17   2011

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  • 象牙質知覚過敏の発症メカニズムとその予防と治療.

    吉山昌宏

    日本歯科医師会雑誌   63 ( 11 )   1187 - 1195   2011

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  • Neutralizing effect by resin-based materials containing silane-coated glass fillers

    Toshiyuki Itota, Toshiyuki Nakatsuka, Kumiko Tanaka, Yoko Tashiro, John F. McCabe, Masahiro Yoshiyama

    DENTAL MATERIALS JOURNAL   29 ( 4 )   362 - 368   2010.7

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    The aim of this study was to evaluate the fluoride release, neutralizing ability and inhibitory effect on secondary caries of resin-based materials containing a silane-coated glass filler. Resin-based materials containing fluoro-boro-alumino-silicate glass coated by 3-methacryloxypropyltrimethoxysilane or 3-a minopropyltrimethoxysilane were used and resin material containing glass filler without coating was used as a control. The fluoride release and pH value after immersion were measured for 10 weeks. The inhibitory effect was also evaluated. During the initial period, the material with 3-aminopropyltrimethoxysilane gave the greater amount of fluoride release and produced a higher pH value compared with the other materials. However, the neutralizing ability of the material with 3-aminopropyltrimethoxysilane filler became weaker with ageing of the specimens. The mean depth of outer lesions was similar among the three materials. Within the limitations of this study, secondary caries around restorations could not be inhibited even for products showing high fluoride releasing and neutralizing ability.

    DOI: 10.4012/dmj.2009-108

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  • クロルヘキシジン含有の酸コンディショナーはレジンと象牙質の接着の寿命を保つ

    伊沢俊次, 西谷佳浩, 吉山昌宏

    ザ・クインテッセンス   29 ( 8 )   116 - 117   2010

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  • 象牙質再生と再建のハーモナイゼーション

    西谷佳浩, 吉山昌宏, 山路公造

    日本歯科評論   70 ( 2 )   151 - 154   2010

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  • 2%クロルヘキシジンが健全象牙質とう蝕影響象牙質の接着強さに与える影響

    高橋圭, 西谷佳浩, 吉山昌宏

    ザ・クインテッセンス   29 ( 1 )   150 - 151   2010

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  • 各種漂白剤処理後のエナメル質に対する接着性の検討

    岸本麻実, 神農泰生, 穴吹優佳, 中田貴, 田中久美子, 西谷佳浩, 吉山昌宏

    日本歯科保存学雑誌   53 ( 6 )   585 - 591   2010

  • A Study of Resin-enamel Adhesion after Tooth Bleaching by Several Bleaching Agents

    Kishimoto Mami, Shinnoo Yasuo, Anabuki Yuka, Nakata Takashi, Tanaka Kumiko, Nishitani Yoshihiro, Yoshiyama Masahiro

    The Japanese Journal of Conservative Dentistry   53 ( 6 )   585 - 591   2010

  • ストップ!The 知覚過敏ー薬剤によるアプローチ

    吉山昌宏

    日本歯科理工学会誌   29 ( 4 )   293 - 296   2010

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  • 象牙質・歯髄複合体再生療法の現状と展望

    吉山昌宏, 斉藤隆史

    日本歯科評論   70 ( 2 )   133 - 134   2010

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  • Effects of Ultrasound on Bone Formation Induced by BMP-2

    Kozo YAMAJI, Maiko NISHIMURA, Yoshihiro NISHITANI, Shunji IZAWA, Tomohiro HOSHIKA, Shintaro SHIODE, Masahiro YOSHIYAMA

    Jounal of Oral Tissue Engineering   8 ( 1 )   47 - 51   2010

  • MMA系レジンセメントのサーマルサイクリング後のおよび水中浸漬後の象牙質接着強さ

    中田貴, 西谷佳浩, 吉山昌宏

    接着歯学   28 ( 2 )   67 - 72   2010

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  • Chlorhexidine-containing acid con-ditioner preserves the longevity of resin-dentin bonds.

    Izawa Syunji, Nishitani Yoshihiro, Yoshiyama Masahiro

    the Qintessence   29 ( 8 )   116 - 117   2010

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  • Innovation of Antin-Hypersensitive Drugs

    Yoshiyama Masahiro

    the Qintessence   29 ( 8 )   142 - 149   2010

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  • 進化し続ける象牙質知覚過敏抑制剤

    吉山昌宏

    ザ・クインテッセンス   29 ( 8 )   142 - 149   2010

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  • Harmony of Dentin Regeneration and Reconstraction

    Nishitani Yoshihiro, Yoshiyama Masahiro, Ymaji Kouzou

    The Nippon Dental Review   70 ( 2 )   151 - 154   2010

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  • Effect 2% chlorhexidine digluconate on the bond strength to normal versus caries-affected dentin

    Takahashi Kei, Nishitani Yoshihiro, Yoshiyama Masahiro

    tha Quintessence   29 ( 1 )   150 - 151   2010

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  • Micro-tensile bond strengths of MMA-based resin cements to dentin after thermal cycling and immersion in water

    Nakata Takashi, Nishitani Yoshihiro, Yoshiyama Masahiro

    Adhesive dentistry   28 ( 2 )   67 - 72   2010

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  • STOP! Dentin hypersensitivity.

    Yoshiyama Masahiro

    The Jornal of Japanese Society for Dental Materials and Devices.   29 ( 4 )   293 - 296   2010

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  • Outlook of Dentin Regeneration

    Yoshiyama Masahiro, Saitou Takashi

    The Nippon Dental Review   70 ( 2 )   133 - 134   2010

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  • Adhesive properties of newly bonding resin Absolute 3

    MORIMOTO S, NISHITANI Y, HOSHIKA T, YAMAJI K, YOSHIYAMA M

    Journal of the Japanese Society for Dental Materials and Devices   28 ( 5 )   250 - 250   2009.9

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    The purpose of this study was to evaluate the properties of Absolute2 and Absolute3. We made specimens to measure micro-tensile bond strengths (MTBS) and observe morphological structure by scanning electron microscopy with Absolute2 and Absolute3.Moreover, specimens bonded to dry enamel and dentin surface were made additionally. MTBS of Absolute3 was higher than those of Absolute2 or Absolute3 bonded to dry tooth surface. It was indicated that the property of Absolute3 was equivalent or superior compared to that of Absolute2.

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  • XPS analysis of the dentin irradiated by Er:YAG laser

    Masanori Omae, Yasuo Shinnou, Kumiko Tanaka, Tomoko Abo, Takashi Nakata, Koichiro Suzuki, Yoshinori Hatsuoka, Naohiro Iwata, Kazushi Yoshikawa, Yoshihiro Nishitani, Kazuyo Yamamoto, Masahiro Yoshiyama

    DENTAL MATERIALS JOURNAL   28 ( 4 )   471 - 476   2009.7

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    The aim of this study was to investigate the effect of Er:YAG laser irradiation on human dentin surface using X-ray photoelectron spectroscopy (XPS). 10 human dentin disks were prepared from extracted human molars for XPS analysis. These specimens were divided into two groups of five: a control group and group that were irradiated by an Er:YAG laser beam (1.00 mJ, 1Hz). All specimens were analyzed by XPS over a wide scanning range and narrow scanning ranges. The Ca/P ratio was calculated from the XPS results.
    In the results, the binding energies of Ca, P, and N in the laser-irradiated group were higher than those in the control group. The Ca/P ratio of the Er:YAG laser irradiated group (1.24 +/- 0.05) was significantly lower than that of the control group (1.52 +/- 0.16). This study showed that Er:YAG laser irradiation decreased Ca/P ratio and denatured the collagen of human dentin.

    DOI: 10.4012/dmj.28.471

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  • Durability of Resin-Dentin Bonds to Water-vs. Ethanol-saturated Dentin

    K. Hosaka, Y. Nishitani, J. Tagami, M. Yoshiyama, W. W. Brackett, K. A. Agee, F. R. Tay, D. H. Pashley

    JOURNAL OF DENTAL RESEARCH   88 ( 2 )   146 - 151   2009.2

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    Higher 24-hour resin-dentin bond strengths are created when ethanol is used to replace water during wet bonding. This in vitro study examined if ethanol-wet-bonding can increase the durability of resin-dentin bonds over longer times. Five increasingly hydrophilic experimental resin blends were bonded to acid-etched dentin saturated with water or ethanol. Following composite build-ups, the teeth were reduced into beams for 24-hour microtensile bond strength evaluation, and for water-aging at 37 degrees C for 3, 6, or 12 months before additional bond strength measurements. Although most bonds made to water-saturated dentin did not change over time, those made to ethanol-saturated dentin exhibited higher bond strengths, and none of them fell over time. Decreased collagen fibrillar diameter and increased interfibrillar spacing were seen in hybrid layers created with ethanol-wet-bonding. Increases in bond strength and durability in ethanol-wet-bonding may be due to higher resin uptake and better resin sealing of the collagen matrix, thereby minimizing endogenous collagenolytic activities.

    DOI: 10.1177/0022034508328910

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  • コラーゲン固定化エチレン-ビニルアルコール共重合体(EVA+C)添加試作石灰化誘導促進性接着材の接着強さと生体親和性.

    神農泰生, 岸本麻実, 穴吹優佳, 山路公造, 西谷佳浩, 田中 亨, 佐野秀彦, 吉山昌宏

    日本再生歯科医学会誌   2009

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  • フロアブルコンポジットレジンのフロー性に関する研究.

    星加知宏, 西谷佳浩, 高橋 圭, 田中久美子, 中田 貴, 山路公造, 吉山昌宏

    接着歯学   2009

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  • 次亜塩素酸ナトリウム処理した象牙質へのMMA系レジンセメント3種の接着強さ.

    中田 貴, 李 相紅, 西谷佳浩, 吉山昌宏

    Adhesive Dentistry   2009

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  • ワンボトルセルフエッチングシステムの脱灰および再石灰化象牙質に対する接着.

    田中久美子, 西谷佳浩, 高橋 圭, 星加知宏, 吉山昌宏

    日本歯科保存学雑誌   2009

  • CLINICAL REPORT クリアフィルSAルーティングを活用した接着修復臨床.

    吉山昌宏

    デンタルマガジン   2009

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  • 臨床座談, 1ステップボンディング材を再考する―「Gボンドプラス」の評価と臨床.

    吉山昌宏, 佐野英彦

    GCサークル   2009

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  • ヒト骨髄間葉系幹細胞を用いた象牙芽細胞分化と象牙質再生.

    伊澤俊次, 山路公造, 星加知宏, 中田 貴, 神農泰生, 西谷佳浩, 吉山昌宏

    日本再生歯科医学会誌   2009

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  • 岡山大学病院周術期管理センター(歯科部門)設立後5ヵ月間の活動内容および今後の展開

    山中玲子, 曽我賢彦, 縄稚久美子, 柳文修, 兒玉直紀, 中田貴, 三浦留美, 羽川操, 竹内哲男, 山根美榮子, 森田学, 高柴正悟, 浅海淳一, 皆木省吾, 吉山昌宏, 下野勉, 窪木拓男, 佐々木朗, 森田潔

    岡山歯学会雑誌   28 ( 1 )   37 - 42   2009

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  • 第三の歯科疾患Tooth Wear 原因、予防、対処法と象牙質知覚過敏症との関連(解説).

    中田貴, 山路公造, 西谷佳浩, 吉山昌宏

    歯界展望   112 ( 3 )   460 - 468   2008

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  • 象牙質接着におけるレジンの親水性の影響.

    西谷佳浩, 高橋 圭, 林 幸則, 星加知宏, 堀川 元, 中田 貴, 田中久美子, 佐野英彦, 吉山昌宏

    接着歯学   26 ( 2 )   92 - 98   2008

  • 特集:Tooth Wearを考える- Tooth Wearとは何か? 知覚過敏症を中心に.

    吉山昌宏, 西谷佳浩

    日本歯科評論   68 ( 7 )   59 - 64   2008

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  • 第三の歯科疾患Tooth Wear 原因、予防、対処法と象牙質知覚過敏症との関連(解説).

    中田貴, 山路公造, 西谷佳浩, 吉山昌宏

    歯界展望   112 ( 3 )   460 - 468   2008

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  • 齲蝕歯周病に次ぐ第三の疾患Tooth Wear(TSL)━象牙質知覚過敏との関連

    吉山昌宏, 中田貴, 西谷佳浩

    The Quintessence   27 ( 4 )   181 - 190   2008

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  • 臼歯垂直修復用コンポジットレジンの物性に関する検討.

    神農泰生, 岸本麻実, 穴吹優佳, 神谷絵里子, 大前正範, 西谷佳浩, 吉山昌宏

    日本歯科保存学雑誌   51 ( 6 )   622 - 628   2008

  • セルフアドヒーシブルーティングセメントの錬和方法がセラミックスとの接着強さに及ぼす影響.

    阿保備子, 宇野 滋, 山田敏元, 田中久美子, 高橋 圭, 西谷佳浩, 吉山昌宏

    接着歯学   26 ( 2 )   106 - 111   2008

  • ワンボトルボンディング材"アブソリュート2"を用いた汚染歯質に対する接着.

    高橋 圭, 西谷佳浩, 星加知宏, 田中久美子, 吉山昌宏

    接着歯学   26 ( 2 )   99 - 105   2008

  • Effects of BMP-2 injected into the palatal sites on bone formation.

    Yamaji K, Takahashi K, Nishitani Y, Izawa S, Horikawa G, Nishimura M, Hoshika T, Yoshiyama M

    J Oral Tissue Engin   6 ( 1 )   62 - 66   2008

  • Dentin Regeneration by Direct Pulp Capping using rhBMP-2

    YAMAJI Kozo, HORIKAWA Gen, NISHITANI Yoshihiro, IZAWA Shunji, YOSHIYAMA Masahiro

    Journal of Oral Tissue Engineering   5 ( 3 )   145 - 149   2008

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    The purpose of this study was to evaluate the effect of direct pulp capping using recombinant human BMP-2 (rhBMP-2) on dentin regeneration. RhBMP-2 (1.0 mg/ml) was dissolved in alginate-based gel (AG). Cavities with the exposed pulp area were prepared of first molars in Wister rats. All cavities were divided into two groups: The exposed pulps were covered with AG contained rhBMP-2 (BMP group), and covered with AG alone (AG group). Then they were sealed with glass ionomer cement (Fuji IILC EM). The animals were sacrificed at 3 and 8 weeks after operation. In both groups, the covered materials were observed at 3 weeks after operation, while they had disappeared and the tertiary dentin formation was observed into the prepared cavity at 8 weeks after operation. Thickness of the tertiary dentin of BMP group was significantly higher than that of AG group (P<0.05). These results suggest that AG is effective scaffold and direct pulp capping using AG contains rhBMP-2 is capable of enhancing dentin regeneration.

    DOI: 10.11223/jarde.5.145

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  • 特集:Tooth Wearを考える- Tooth Wearとは何か? 知覚過敏症を中心に.

    吉山昌宏, 西谷佳浩

    日本歯科評論   68 ( 7 )   59 - 64   2008

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  • P09. New treatment of bone regeneration using combined recombinant human BMP-2 and Alginic acid gel(Poster Presentation,The 5^<th> Annual Meeting of Japanese Association of Regeneration Dentistry)

    Yamaji Kozo, Nishitani Yoshihiro, Izawa Shunji, Doi Junichi, Shinno Yasuo, Omae Masanori, Abo Youko, Yamauchi Junichi, Yoshiyama Masahiro

    Journal of the Japanese Association of Regenerative Dentistry   5 ( 1 )   57 - 57   2007.12

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  • Effect of pretreatment for self-adhesive resin cements

    HOSHIKA Tomohiro, NISHITANI Yoshihiro, YAMAJI Kozo, TAKAHASHI Kei, YOSHIYAMA Masahiro

    25 ( 2 )   122 - 122   2007.10

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  • Practice Training of Conservative Dentistry on Postgraduate Clinical Training Course at Okayama University Hospital

    KONO Takayuki, YAMAJI Kozo, YOSHIYAMA Masahiro, ARAI Hideo, TAKASHIBA Shogo, TORII Yasuhiro

    日本歯科保存学雑誌 = THE JAPANESE JOURNAL OF CONSERVATIVE DENTISTRY   50   2007.10

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  • Effects of dose of recombinant human BMP-2 on bone formation at palatal sites in young and old rats

    Kozo Yamaji, Masamitsu Kawanami, Atsushi Matsumoto, Tomoomi Odajima, Yoshihiro Nishitani, Kensuke Iwasaka, Keiko Yoshimitsu, Masahiro Yoshiyama

    DENTAL MATERIALS JOURNAL   26 ( 4 )   481 - 486   2007.7

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    This study was designed to examine the effects of dose of recombinant human BMP-2 (rhBMP-2) on bone formation at palatal sites in 10-week-old (10w) and 70-week-old (70w) rats, when combined with a polylactate-polyglycolate copolymer/gelatine sponge (PGS).
    New bone formation was observed at six weeks after implantation. In the 10w rats, thickness of new bone (TNB) increased as the dosage increased from 0 mu g to 4 mu g, and decreased significantly as the dosage increased from 8 mu g to 24 mu g. In contrast, in the 70w rats, TNB increased as the dosage increased from 0 mu g to 16 mu g, and did not significantly change as the dosage increased from 16 mu g to 24 lug.
    These results suggest that the most effective dosage of rhBMP-2 for induction of bone formation varies according to age.

    DOI: 10.4012/dmj.26.481

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  • Effects of dose of recombinant human BMP-2 on bone formation at palatal sites in young and old rats

    Kozo Yamaji, Masamitsu Kawanami, Atsushi Matsumoto, Tomoomi Odajima, Yoshihiro Nishitani, Kensuke Iwasaka, Keiko Yoshimitsu, Masahiro Yoshiyama

    DENTAL MATERIALS JOURNAL   26 ( 4 )   481 - 486   2007.7

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    This study was designed to examine the effects of dose of recombinant human BMP-2 (rhBMP-2) on bone formation at palatal sites in 10-week-old (10w) and 70-week-old (70w) rats, when combined with a polylactate-polyglycolate copolymer/gelatine sponge (PGS).
    New bone formation was observed at six weeks after implantation. In the 10w rats, thickness of new bone (TNB) increased as the dosage increased from 0 mu g to 4 mu g, and decreased significantly as the dosage increased from 8 mu g to 24 mu g. In contrast, in the 70w rats, TNB increased as the dosage increased from 0 mu g to 16 mu g, and did not significantly change as the dosage increased from 16 mu g to 24 lug.
    These results suggest that the most effective dosage of rhBMP-2 for induction of bone formation varies according to age.

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  • Effect of wet vs. dry testing on the mechanical properties of hydrophilic self-etching primer polymers

    Keiichi Hosaka, Junji Tagami, Yoshihiro Nishitani, Masahiro Yoshiyama, Marcela Carrilho, Franklin R. Tay, Kelli A. Agee, David H. Pashley

    EUROPEAN JOURNAL OF ORAL SCIENCES   115 ( 3 )   239 - 245   2007.6

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    Self-etching primers and adhesives contain very hydrophilic methacrylate monomers that result in high water sorptions by their polymers. Water sorption plasticizes the polymers and lowers their mechanical properties. The purpose of this work was to rank the hydrophilicity of a series of acidic primers by their Hoy's solubility parameters (delta) to determine if there was a significant relationship between the delta of polymers and their mechanical properties. A series of six acidic primer blends containing a fixed concentration of phenyl-P but variable amounts of 2-hydroxyethyl methacrylate (HEMA), 2,2 bi[4-(2-hydroxy-3-methacryloyloxy) propane (BisGMA), and triethyleneglycol dimethacrylate (TEGDMA) was formulated and their Hoy's solubility parameters calculated. The polymers were cast into small 'I' beams and light-cured. The modulus of elasticity (E) and ultimate tensile strength (UTS) were measured in dry polymers and after immersion in water for 24 h. The results showed significant correlations between E and UTS under dry or wet conditions. Both E and UTS fell significantly when the specimens were immersed in water. After water immersion, the E and UTS showed significant correlations with Hoy's delta(P) values. Both E and UTS correlated significantly with the BisGMA concentration of the polymers, either wet or dry. The percentage changes in E or UTS were significantly correlated with the water sorption of the polymers.

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  • Effect of wet vs. dry testing on the mechanical properties of hydrophilic self-etching primer polymers

    Keiichi Hosaka, Junji Tagami, Yoshihiro Nishitani, Masahiro Yoshiyama, Marcela Carrilho, Franklin R. Tay, Kelli A. Agee, David H. Pashley

    EUROPEAN JOURNAL OF ORAL SCIENCES   115 ( 3 )   239 - 245   2007.6

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    Self-etching primers and adhesives contain very hydrophilic methacrylate monomers that result in high water sorptions by their polymers. Water sorption plasticizes the polymers and lowers their mechanical properties. The purpose of this work was to rank the hydrophilicity of a series of acidic primers by their Hoy's solubility parameters (delta) to determine if there was a significant relationship between the delta of polymers and their mechanical properties. A series of six acidic primer blends containing a fixed concentration of phenyl-P but variable amounts of 2-hydroxyethyl methacrylate (HEMA), 2,2 bi[4-(2-hydroxy-3-methacryloyloxy) propane (BisGMA), and triethyleneglycol dimethacrylate (TEGDMA) was formulated and their Hoy's solubility parameters calculated. The polymers were cast into small 'I' beams and light-cured. The modulus of elasticity (E) and ultimate tensile strength (UTS) were measured in dry polymers and after immersion in water for 24 h. The results showed significant correlations between E and UTS under dry or wet conditions. Both E and UTS fell significantly when the specimens were immersed in water. After water immersion, the E and UTS showed significant correlations with Hoy's delta(P) values. Both E and UTS correlated significantly with the BisGMA concentration of the polymers, either wet or dry. The percentage changes in E or UTS were significantly correlated with the water sorption of the polymers.

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  • Effect of a desensitizing agent containing glutaraldehyde and HEMA on bond strength to Er : YAG laser-irradiated dentine

    Masanori Omae, Masataka Inoue, Toshiyuki Itota, Werner J. Finger, Masayoshi Inoue, Kumiko Tanaka, Kazuyo Yamamoto, Masahiro Yoshiyama

    JOURNAL OF DENTISTRY   35 ( 5 )   398 - 402   2007.5

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    Objectives: The aim of this study was to investigate whether a desensitizing agent (GLUMA Desensitizer) containing glutaraldehyde and HEMA improved the bond strength and bonding durability of a self-etching primer adhesive to Er:YAG-irradiated dentine.
    Method: Dentine of 120 human molars was exposed by wet grinding on SiC paper for bond strength testing. Thirty specimens each were allocated to the following treatment groups: (1) control; (2) Er:YAG laser irradiation; (3) Er:YAG laser irradiation followed by application of GLUMA Desensitizer; (4) Er:YAG laser irradiation followed by application of GLUMA Desensitizer and 10s rinsing with water. Composite cylinders were bonded to the dentine surfaces with a self-etching priming adhesive system. Tensile bond strengths (TBS) of 10 specimens of each treatment group were measured after 24-h water storage, 6 months water storage and 12 months water storage, respectively, and the failure modes were analyzed. TBS data were statistically treated by two-way ANOVA and Fisher's PLSD test at a significance level of p &lt; 0.05.
    Results: TBSs for the GLUMA-non rinse and GLUMA-rinse groups were significantly higher than for the laser group at 24 h and 12 months. Specimens from the Er:YAG-irradiated dentine group had significantly lower bond strengths than the control group at each storage time. All control specimens showed cohesive fractures in resin close to the bonding interface whereas the Er:YAG laser-irradiated groups showed both dentine cohesive, resin cohesive and dentine-resin mixed failures.
    Conclusion: Application of GLUMA Desensitizer to Er:YAG-irradiated dentine increases the bond strength and durability of the self-etching priming adhesive used. (c) 2006 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.jdent.2006.11.004

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  • Effect of a desensitizing agent containing glutaraldehyde and HEMA on bond strength to Er : YAG laser-irradiated dentine

    Masanori Omae, Masataka Inoue, Toshiyuki Itota, Werner J. Finger, Masayoshi Inoue, Kumiko Tanaka, Kazuyo Yamamoto, Masahiro Yoshiyama

    JOURNAL OF DENTISTRY   35 ( 5 )   398 - 402   2007.5

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    Objectives: The aim of this study was to investigate whether a desensitizing agent (GLUMA Desensitizer) containing glutaraldehyde and HEMA improved the bond strength and bonding durability of a self-etching primer adhesive to Er:YAG-irradiated dentine.
    Method: Dentine of 120 human molars was exposed by wet grinding on SiC paper for bond strength testing. Thirty specimens each were allocated to the following treatment groups: (1) control; (2) Er:YAG laser irradiation; (3) Er:YAG laser irradiation followed by application of GLUMA Desensitizer; (4) Er:YAG laser irradiation followed by application of GLUMA Desensitizer and 10s rinsing with water. Composite cylinders were bonded to the dentine surfaces with a self-etching priming adhesive system. Tensile bond strengths (TBS) of 10 specimens of each treatment group were measured after 24-h water storage, 6 months water storage and 12 months water storage, respectively, and the failure modes were analyzed. TBS data were statistically treated by two-way ANOVA and Fisher's PLSD test at a significance level of p &lt; 0.05.
    Results: TBSs for the GLUMA-non rinse and GLUMA-rinse groups were significantly higher than for the laser group at 24 h and 12 months. Specimens from the Er:YAG-irradiated dentine group had significantly lower bond strengths than the control group at each storage time. All control specimens showed cohesive fractures in resin close to the bonding interface whereas the Er:YAG laser-irradiated groups showed both dentine cohesive, resin cohesive and dentine-resin mixed failures.
    Conclusion: Application of GLUMA Desensitizer to Er:YAG-irradiated dentine increases the bond strength and durability of the self-etching priming adhesive used. (c) 2006 Elsevier Ltd. All rights reserved.

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  • Bond strength of one step bonding systems to demineralized root dentin

    DOI J., OMAE M., YAMAJI K., NISHITANI Y., YOSHIYAMA M.

    Journal of the Japanese Society for Dental Materials and Devices   26 ( 2 )   224 - 224   2007.4

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  • Use of Hoy's solubility parameters to predict water sorption/solubility of experimental primers and adhesives

    Yoshihiro Nishitani, Masahiro Yoshiyama, Keiichi Hosaka, Junji Tagami, Adam Donnelly, Marcela Carrilho, Franklin R. Tay, David H. Pashley

    EUROPEAN JOURNAL OF ORAL SCIENCES   115 ( 1 )   81 - 86   2007.2

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    Self-etching primers and adhesives contain very hydrophilic acidic monomers that result in high water sorption/solubilities of their polymers. However, the chemical composition of these products varies widely. The purpose of this work was to vary the chemical composition of experimental self-etching primers and adhesives to determine if the water sorption/solubility of the polymers were affected in a predictable manner. The Hoy's solubility parameters of these mixtures were calculated to permit ranking of the degree of hydrophilicity of the polymers. Water sorption/solubility was measured according to ISO 4049. The results showed highly significant (R-2 = 0.86, P &lt; 0.001) correlations between water sorption and Hoy's solubility parameter for polar forces (delta(p)) of the polymers. Similar correlations were obtained between polymer solubility and dp. When these results were compared with previously published results obtained with more hydrophobic resins, excellent correlations were obtained, indicating that Hoy's dp values may be used to predict the water sorption behavior of methylmethacrylate polymers.

    DOI: 10.1111/j.1600-0722.2007.00430.x

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  • Use of Hoy's solubility parameters to predict water sorption/solubility of experimental primers and adhesives

    Yoshihiro Nishitani, Masahiro Yoshiyama, Keiichi Hosaka, Junji Tagami, Adam Donnelly, Marcela Carrilho, Franklin R. Tay, David H. Pashley

    EUROPEAN JOURNAL OF ORAL SCIENCES   115 ( 1 )   81 - 86   2007.2

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    Self-etching primers and adhesives contain very hydrophilic acidic monomers that result in high water sorption/solubilities of their polymers. However, the chemical composition of these products varies widely. The purpose of this work was to vary the chemical composition of experimental self-etching primers and adhesives to determine if the water sorption/solubility of the polymers were affected in a predictable manner. The Hoy's solubility parameters of these mixtures were calculated to permit ranking of the degree of hydrophilicity of the polymers. Water sorption/solubility was measured according to ISO 4049. The results showed highly significant (R-2 = 0.86, P &lt; 0.001) correlations between water sorption and Hoy's solubility parameter for polar forces (delta(p)) of the polymers. Similar correlations were obtained between polymer solubility and dp. When these results were compared with previously published results obtained with more hydrophobic resins, excellent correlations were obtained, indicating that Hoy's dp values may be used to predict the water sorption behavior of methylmethacrylate polymers.

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  • 特集:接着性コンポジットレジン修復の基礎と臨床 基礎編 う蝕と歯頸部欠損の構造と処置 歯頸部欠損の構造とその処置.

    吉山昌宏

    日本歯科評論(0289-0909)特別号   22 - 27   2007

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  • 平成18年度岡山大学医学部・歯学部附属病院歯科医師臨床研修における歯科保存分野診療研修の分析.

    河野隆幸, 山路公造, 吉山昌宏, 新井英雄, 高柴正悟, 鳥井康弘

    日本歯科保存学雑誌   50 ( 6 )   731 - 739   2007

  • ホワイトニング前後における歯質への着色量の変化に関する研究.

    大前正範, 星加知宏, 末松亮, 西村綾乃, 美甘真, 穴吹優佳, 神谷絵里子, 岸本麻実, 林真千子, 神農泰生, 吉山昌宏

    日本歯科保存学雑誌   50 ( 6 )   675 - 680   2007

  • ホワイトニング前後における歯質への着色量の変化に関する研究.

    大前正範, 星加知宏, 末松亮, 西村綾乃, 美甘真, 穴吹優佳, 神谷絵里子, 岸本麻実, 林真千子, 神農泰生, 吉山昌宏

    日本歯科保存学雑誌   50 ( 6 )   675 - 680   2007

  • Dopamine Receptor Presence in the Rat Area Postrema Identified by RT-PCR, Immunohistochemistry, and In Situ Hybridization

    Shunji Izawa, Tomoichiro Yamaai, Yoshiki Mukudai, Kozo Yamaji, Yoshihiro Nishitani, Toshiyuki Itota, Ryuji Matsuo, Masaharu Takigawa, Masahiro Yoshiyama

    Journal of Oral Biosciences   49 ( 4 )   259 - 268   2007

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    Dopamine (DA) is a major central nervous system (CNS) neurotransmitter with many important physiological activities. Investigations into the neuroanatomy and neurologic functions of the dopaminergic neural systems have generated much debate. Regarding neuroanatomy, physiological and pharmacological criteria have divided DA receptors into D1 and D2 subtypes. The genes encoding these subtypes have been cloned and classified into a D1 subfamily encompassing D1 and D5 receptors and a D2 subfamily with D2, D3, and D4. Based on the sequences of the cloned receptors, we prepared antibodies and riboprobes to elucidate the expression of the corresponding proteins and mRNAs in the rat area postrema (AP) by immunohistochemistry and in situ hybridization (ISH). The AP was obtained from adult male Sprague-Dawley rats undergoing brain surgery, and tissue samples were used for RT-PCR, immunohistochemistry, and ISH. The results showed that D2 and D5 receptors and their mRNAs exist in the rat AP. On the other hand, D1, D3, and D4 receptors and their mRNAs were not detected. © 2007, Japanese Association for Oral Biology. All rights reserved.

    DOI: 10.2330/joralbiosci.49.259

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  • 特集:接着性コンポジットレジン修復の基礎と臨床 基礎編 接着の進歩と研究・開発の現状 レジンボンディング材の将来展望.

    吉山昌宏

    日本歯科評論(0289-0909)特別号   116 - 119   2007

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  • 特集:接着性コンポジットレジン修復の基礎と臨床 基礎編 う蝕と歯頸部欠損の構造と処置 歯頸部欠損の構造とその処置.

    吉山昌宏

    日本歯科評論(0289-0909)特別号   22 - 27   2007

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  • 平成18年度岡山大学医学部・歯学部附属病院歯科医師臨床研修における歯科保存分野診療研修の分析.

    河野隆幸, 山路公造, 吉山昌宏, 新井英雄, 高柴正悟, 鳥井康弘

    日本歯科保存学雑誌   50 ( 6 )   731 - 739   2007

  • Effect of light-curing of the bonding system on bond strength of Clearfil Esthetic Cement-dentin

    YOSHIMITSU Keiko, DOI Junichi, TAKABATAKE Yasumitsu, YAMAJI Kozo, ITOTA Toshiyuki, YOSHIYAMA Masahiro

    Adhesive Dentistry   25 ( 1 )   1 - 6   2007

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    This study investigated the effect of light-curing of Clearfil DC Bond (DC Bond) on the micro-tensile bond strength of Clearfil Esthetic Cement to dentin. Extracted human teeth were used in this study. The coronal dentin surfaces were prepared, and treated with DC Bond with or without light-curing, or ED primer II according to the manufacturer's instruction and luted composite block using Clearfil Esthetic Cement. The bond strengths were measured with the micro-tensile bond test. The bond strengths were statistically compared with ANOVA and Duncan's new multiple range tests. The debonded specimens and resin-dentin interfaces were also examined by SEM. There were no significant differences in bond strength among all the groups. In the SEM observations, no morphological differences were found among all the groups. For all fractured surfaces in the debonded DC Bond with light-curing group, cohesive failure in resin was observed. Adhesive fracture was predominantly observed in the debonded DC Bond without light-curing group. The cohesive failure in resin was predominantly observed in the debonded ED primer group.<BR>In conclusion, although the type of fractured surface for the DC Bond without light-curing group differed from that for the DC Bond with light-curing group, there was no significant difference in the dentin bond strength of Clearfil Esthetic Cement between the two groups.

    DOI: 10.11297/adhesdent1983.25.1

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  • Bonding of self-etching adhesive systems to demineralized and remineralized dentin

    TANAKA Kumiko, DOI Junichi, TAKABATAKE Yasumitsu, NISHITANI Yoshihiro, YAMAJI Kozo, ITOTA Toshiyuki, YOSHIYAMA Masahiro

    Adhesive Dentistry   25 ( 1 )   12 - 18   2007

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    This study investigated the bond strengths of one-or two-step self-etching adhesive systems to human sound, demineralized and remineralized dentin. Remineralized dentin was created by remineralization for1or4weeks after demineralization. The dentin surfaces were treated with Clearfil SE Bond or Clearfil Tri-S Bond and the microtensile bond strengths were measured. There were no significant differences in the bond strength of Clearfil SE Bond among the three groups (demineralized, 1-week and4-week remineralized dentin groups) except for the sound dentin group. On the other hand, the bond strength of Clearfil Tri-S Bond to1-week remineralized dentin was significantly higher than those to demineralized dentin and4-week remineralized dentin. In comparing the two adhesive systems, Clearfil SE Bond produced higher bond strengths to all dentin surfaces than Clearfil Tri-S Bond. In conclusion, it is suggested that the difference of the adhesive system affected the bond strength to demineralized and remineralized dentin.

    DOI: 10.11297/adhesdent1983.25.12

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  • Effect of light-curing of the bonding system on bond strength of Clearfil Esthetic Cement-dentin

    YOSHIMITSU Keiko, DOI Junichi, TAKABATAKE Yasumitsu, YAMAJI Kozo, ITOTA Toshiyuki, YOSHIYAMA Masahiro

    Adhesive Dentistry   25 ( 1 )   1 - 6   2007

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    This study investigated the effect of light-curing of Clearfil DC Bond (DC Bond) on the micro-tensile bond strength of Clearfil Esthetic Cement to dentin. Extracted human teeth were used in this study. The coronal dentin surfaces were prepared, and treated with DC Bond with or without light-curing, or ED primer II according to the manufacturer's instruction and luted composite block using Clearfil Esthetic Cement. The bond strengths were measured with the micro-tensile bond test. The bond strengths were statistically compared with ANOVA and Duncan's new multiple range tests. The debonded specimens and resin-dentin interfaces were also examined by SEM. There were no significant differences in bond strength among all the groups. In the SEM observations, no morphological differences were found among all the groups. For all fractured surfaces in the debonded DC Bond with light-curing group, cohesive failure in resin was observed. Adhesive fracture was predominantly observed in the debonded DC Bond without light-curing group. The cohesive failure in resin was predominantly observed in the debonded ED primer group.<BR>In conclusion, although the type of fractured surface for the DC Bond without light-curing group differed from that for the DC Bond with light-curing group, there was no significant difference in the dentin bond strength of Clearfil Esthetic Cement between the two groups.

    DOI: 10.11297/adhesdent1983.25.1

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  • 岡山大学病院特殊歯科総合治療部における開設以来23年間の障害者歯科診療の実態調査 当科の現状と地域の障害者歯科医療.

    森貴幸, 有岡享子, 森田幸介, 石原牧子, 北ふみ, 梶原京子, 石田瞭, 江草正彦, 宮脇卓也, 吉山昌宏

    岡山歯学会雑誌   26 ( 2 )   87 - 95   2007

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  • ワンボトルワンステップ接着剤の採取後の放置時間が歯質接着性に及ぼす影響.

    山田敦子, 高畑安光, 吉光景子, 田中久美子, 野本正盛, 田代陽子, 大前正範, 山路公造, 神農泰生, 土居潤一, 西谷佳浩, 糸田俊之, 吉山昌宏

    日本歯科保存学雑誌   50 ( 2 )   126 - 132   2007

  • ワンボトルワンステップ接着剤の採取後の放置時間が歯質接着性に及ぼす影響.

    山田敦子, 高畑安光, 吉光景子, 田中久美子, 野本正盛, 田代陽子, 大前正範, 山路公造, 神農泰生, 土居潤一, 西谷佳浩, 糸田俊之, 吉山昌宏

    日本歯科保存学雑誌   50 ( 2 )   126 - 132   2007

  • Bonding of self-etching adhesive systems to demineralized and remineralized dentin

    TANAKA Kumiko, DOI Junichi, TAKABATAKE Yasumitsu, NISHITANI Yoshihiro, YAMAJI Kozo, ITOTA Toshiyuki, YOSHIYAMA Masahiro

    Adhesive Dentistry   25 ( 1 )   12 - 18   2007

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    This study investigated the bond strengths of one-or two-step self-etching adhesive systems to human sound, demineralized and remineralized dentin. Remineralized dentin was created by remineralization for1or4weeks after demineralization. The dentin surfaces were treated with Clearfil SE Bond or Clearfil Tri-S Bond and the microtensile bond strengths were measured. There were no significant differences in the bond strength of Clearfil SE Bond among the three groups (demineralized, 1-week and4-week remineralized dentin groups) except for the sound dentin group. On the other hand, the bond strength of Clearfil Tri-S Bond to1-week remineralized dentin was significantly higher than those to demineralized dentin and4-week remineralized dentin. In comparing the two adhesive systems, Clearfil SE Bond produced higher bond strengths to all dentin surfaces than Clearfil Tri-S Bond. In conclusion, it is suggested that the difference of the adhesive system affected the bond strength to demineralized and remineralized dentin.

    DOI: 10.11297/adhesdent1983.25.12

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  • Dopamine Receptor Presence in the Rat Area Postrema Identified by RT-PCR, Immunohistochemistry, and In Situ Hybridization

    Shunji Izawa, Tomoichiro Yamaai, Yoshiki Mukudai, Kozo Yamaji, Yoshihiro Nishitani, Toshiyuki Itota, Ryuji Matsuo, Masaharu Takigawa, Masahiro Yoshiyama

    Journal of Oral Biosciences   49 ( 4 )   259 - 268   2007

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    Dopamine (DA) is a major central nervous system (CNS) neurotransmitter with many important physiological activities. Investigations into the neuroanatomy and neurologic functions of the dopaminergic neural systems have generated much debate. Regarding neuroanatomy, physiological and pharmacological criteria have divided DA receptors into D1 and D2 subtypes. The genes encoding these subtypes have been cloned and classified into a D1 subfamily encompassing D1 and D5 receptors and a D2 subfamily with D2, D3, and D4. Based on the sequences of the cloned receptors, we prepared antibodies and riboprobes to elucidate the expression of the corresponding proteins and mRNAs in the rat area postrema (AP) by immunohistochemistry and in situ hybridization (ISH). The AP was obtained from adult male Sprague-Dawley rats undergoing brain surgery, and tissue samples were used for RT-PCR, immunohistochemistry, and ISH. The results showed that D2 and D5 receptors and their mRNAs exist in the rat AP. On the other hand, D1, D3, and D4 receptors and their mRNAs were not detected. © 2007, Japanese Association for Oral Biology. All rights reserved.

    DOI: 10.2330/joralbiosci.49.259

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  • 岡山大学病院特殊歯科総合治療部における開設以来23年間の障害者歯科診療の実態調査 当科の現状と地域の障害者歯科医療.

    森貴幸, 有岡享子, 森田幸介, 石原牧子, 北ふみ, 梶原京子, 石田瞭, 江草正彦, 宮脇卓也, 吉山昌宏

    岡山歯学会雑誌   26 ( 2 )   87 - 95   2007

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  • 特集:接着性コンポジットレジン修復の基礎と臨床 基礎編 接着の進歩と研究・開発の現状 レジンボンディング材の将来展望.

    吉山昌宏

    日本歯科評論(0289-0909)特別号   116 - 119   2007

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  • P15.アルギン酸ゲルをスキャホールドとしたrhBMP-2移植による組織反応(一般演題(ポスター展示),第4回日本再生歯科医学会学術大会および総会 硬組織再生の新たな展開)

    山路 公造, 糸田 俊之, 伊澤 俊次, 西谷 佳浩, 野本 正盛, 山内 淳一, 吉山 昌宏

    日本再生歯科医学会誌   4 ( 1 )   78 - 78   2006.12

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  • P01.生体吸収性創傷被覆材Kurabio gelに対する象牙質・歯髄複合体の反応(一般演題(ポスター展示),第4回日本再生歯科医学会学術大会および総会 硬組織再生の新たな展開)

    田代 陽子, 糸田 俊之, 高木 了, 山路 公造, 伊澤 俊次, 神農 泰生, 吉山 昌宏

    日本再生歯科医学会誌   4 ( 1 )   71 - 71   2006.12

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  • Effects of resin hydrophilicity on dentin bond strength

    Y. Nishitani, M. Yoshiyama, A. M. Donnelly, K. A. Agee, J. Sword, F. R. Tay, D. H. Pashley

    JOURNAL OF DENTAL RESEARCH   85 ( 11 )   1016 - 1021   2006.11

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    The purpose of this study was to determine if hydrophobic resins can be coaxed into dentin wet with ethanol instead of water. The test hypothesis was that dentin wet with ethanol would produce higher bond strengths for hydrophobic resins than would dentin wet with water. This study examined the microtensile bond strength of 5 experimental adhesives (50 wt% ethanol/50% comonomers) of various degrees of hydrophilicity to acid-etched dentin that was left moist with water, moist with ethanol, or air-dried. Following composite buildups, hourglass-shaped slabs were prepared from the bonded teeth for microtensile testing. For all 3 types of dentin surfaces, higher bond strengths were achieved with increased resin hydrophilicity. The lowest bond strengths were obtained on dried dentin, while the highest bond strengths were achieved when dentin was bonded moist with ethanol. Wet-bonding with ethanol achieved higher bond strengths with hydrophobic resins than were possible with water-saturated matrices.

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  • Bone formation induced by combined recombinant human BMP-2 and atelocollagen sponge in vivo

    YAMAJI K., ITOTA T., DOI J., TASHIRO Y., OMAE M., NISHITANI Y., YOSHIYAMA M.

    Journal of the Japanese Society for Dental Materials and Devices   25 ( 2 )   186 - 186   2006.4

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  • Activation of gelatinolytic/collagenolytic activity in dentin by self-etching adhesives

    Y Nishitani, M Yoshiyama, B Wadgaonkar, L Breschi, F Mannello, A Mazzoni, RM Carvalho, L Tjaderhane, FR Tay, DH Pashley

    EUROPEAN JOURNAL OF ORAL SCIENCES   114 ( 2 )   160 - 166   2006.4

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    Mild acids are known to activate dentin matrix metalloproteinase (MMPs). All self-etching dental adhesives are acidic (pH 1.5-2.7) and may activate dentin MMPs. The purpose of this study was to compare the ability of several all-in-one adhesives to activate gelatinolytic and collagenolytic activities in powdered mineralized dentin. Powdered dentin made from human teeth was mixed with all-in-one adhesives (Clearfil Tri-S Bond, G-Bond, Adper Prompt L-Pop) or a self-etching primer (Clearfil SE Bond primer) for varying times and then the reaction was stopped by extracting the adhesives using acetone. Fresh untreated mineralized dentin powder had a gelatinolytic activity of 3.31 +/- 0.39 relative fluorescent units (RFU) per mg dry weight (24 h) that increased, over storage time, to 87.5 RFU mg(-1) (24 h) after 6-8 wk. When fresh powder was treated with acidic Tri-S Bond, the gelatinolytic activity increased from 3.24 +/- 0.70 RFU mg(-1) to &gt; 112.5 RFU mg(-1) (24 h) after 20 min and then remained unchanged. Monomers with lower pH values produced less activity. There was a significant, direct correlation between gelatinolytic activity and pH, with Tri-S giving the highest activity. Coating dentin powder with Tri-S resin prevented fluorescent substrates from gaining access to the enzyme, even though it activated the enzyme. In conclusion, self-etch adhesives may activate latent MMP and increase the activity to near-maximum levels and contribute to the degradation of resin-dentin bonds over time.

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  • Effect of fluoride-releasing liner on demineralized dentin

    Toshiyuki Itota, Satoshi Nakabo, Yasuhiro Torii, Tomoko Narukami, Junichi Doi, Masahiro Yoshiyama

    QUINTESSENCE INTERNATIONAL   37 ( 4 )   297 - 303   2006.4

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    Objective: The aim Of this study was to evaluate the remineralization of residual demineralized dentin underneath restorations by fluoride-releasing liners in vitro. Method and materials: Two glass-ionomer cement liners, Lining Cement (GC) and RK-141A (GC), and two light-cured resin liners with and without 5 wt% NaF were used in this study. The resin liners were made by mixing TEGDMA and bis-GMA. Class 5 cavities were prepared on extracted human premolars. Demineralized dentin was promoted by using a bacterial caries induction system at the cavity floor. Cavities were restored with a resin composite following application of each liner. Specimens were then stored for 4 weeks at 37 degrees C and 100% humidity. After storage, the specimens were cut through the restorations, and axial sections of about 80-mu m thickness were prepared. Contact microradiographs were taken, and the radiopacity of the demineralized dentin layer underneath the liner was analyzed. Results: The ratios of radiopacity of demineralized dentin under the fluoride-releasing liners were significantly higher than those under the resin liner without fluoride release. Although the amounts of fluoride release from the glass-ionomer cement liners were lower than that from the resin liner with fluoride release, there were no significant differences in the ratios of radiopacity in demineralized dentin layers among the 3 liners with fluoride release. Conclusion: Although the fluoride released from liners can enhance remineralization of demineralized dentin, the amount of fluoride release does not affect the ratio of radiopacity in the remineralized dentin.

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  • Bone Formation Induced by Recombinant Human BMP-2 Combined with Bioabsorbable Material at Subperiosteal Sites

    YAMAJI Kozo, NISHITANI Yoshihiro, IZAWA Shunji, SHINNO Yasuo, OMAE Masanori, YOSHIYAMA Masahiro

    Journal of Oral Tissue Engineering   4 ( 2 )   101 - 105   2006

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    The purpose of this study was to evaluate the effect of bone formation induced by recombinant human BMP-2 (rhBMP-2) combined with bioabsorbable material Kurabio<sup>&reg;</sup>AG (AG) at palatal subperiosteal sites in Wistar rats. AG was freeze-dried alginated gel dressing.<BR>Experimental sites were divided into three groups according to the implans : BMP group (rhBMP-2 combined with AG), AG group (AG alone) and Control group.<BR>In every group, infected region or atypical cell proliferation was not observed, and new bone formation was observed at 6 weeks after implantation. Thickness of new bone (TNB) of BMP group was significantly higher than that of AG and Control groups. There was no significant difference in TNB between AG and Control groups.<BR>These results suggest that rhBMP-2 combined with AG have the ability to promote bone formation, although AG alone do not have any effect on bone formation.

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  • アクティブ処理を採用するワンステップ接着システムのう蝕象牙質への接着性.

    趙 暁華, 吉山昌宏

    接着歯学   2006

  • フッ素徐放性ワンステップ接着システムの象牙質接着性に関する研究.

    趙 暁華, 吉山昌宏

    接着歯学   2006

  • Study on Bone Formation Induced by Recombinant Human BMP-2 at Palatal Sites in Adult Rats

    YAMAJI Kozo, ITOTA Toshiyuki, IZAWA Shunji, NISHITANI Yoshihiro, YOSHIYAMA Masahiro

    Journal of Oral Tissue Engineering   4 ( 1 )   37 - 42   2006

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    This study was designed to examine the effects of bone formation induced by recombinant human BMP-2 (rhBMP-2), which was implanted together with a poly-lactate-polyglycolate-copolymer/gelatine sponge (PGS) at palatal sites in 30-week- old male Wister rats. The rats were divided into four groups according to the dose of rhBMP-2: 0&micro;g, 4&micro;g, 8&micro;g and 16&micro;g.<BR>New bone formation was observed in every group, and new bone was continuous with the original bone at 6 weeks after implantation. Thickness of new bone (TNB) increased as the dose increased from 0&micro;g to 8&micro;, reached the maximal level at 8&micro;g. In contrast, TNB decreased significantly as the dose increased from 8&micro;g to 16&micro;g.<BR>The results of this study indicate that new bone formation varies according to the dose of rhBMP-2 at palatal sites in adult rats.

    DOI: 10.11223/jarde.4.37

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  • Dentin/pulp complex regeneration by direct pulp capping using a bioabsorbable material

    TASHIRO Yoko, ITOTA Toshiyuki, TAKAGI Ryo, YAMAJI Kozo, SHINNO Yasuo, YOSHIYAMA Masahiro

    49   210 - 210   2006

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  • 特集:象牙質接着を考える-そのシステム・メカニズム・耐久性- レジン接着システムの現状とその展望.

    吉山昌宏

    DE   156,1-2?   2006

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  • 3.生体吸収性創傷被覆材を用いた象牙質・歯髄複合体の再生(一般口演,第3回日本再生歯科医学会学術大会および総会)

    糸田 俊之, 田代 陽子, 高木 了, 山路 公造, 神農 泰生, 吉山 昌宏

    日本再生歯科医学会誌   3 ( 1 )   65 - 65   2005.12

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  • Tensile strength of mineralized/demineralized human normal and carious dentin

    Y Nishitani, M Yoshiyama, FR Tay, B Wadgaonkar, J Waller, K Agee, DH Pashley

    JOURNAL OF DENTAL RESEARCH   84 ( 11 )   1075 - 1078   2005.11

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    The bond strengths of resins to caries-affected dentin are low. This could be due to weakened organic matrix. The purpose of this work was to determine if the ultimate tensile strength (UTS) of excavated carious dentin is weaker than that of normal dentin. Soft caries was excavated from extracted human molars, and the tooth was vertically sectioned into slabs. Each slab was trimmed to an hourglass shape, parallel or perpendicular to the tubule direction. Half of the specimens were mineralized, while the other half were completely demineralized in EDTA. ANOVA on ranks showed that the three-factor interactions (mineralization, caries, tubule direction) were all significant (p &lt; 0.0001), indicating that mineralization and tubule direction gave different UTS results in normal and caries-affected dentin. No significant differences were seen between the UTS of normal and and that of caries-affected demineralized dentin in the parallel or perpendicular group. The matrix of demineralized caries-affected dentin was as strong as that of normal demineralized dentin when tested in the same direction.

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  • Fluoride release from aged resin composites containing fluoridated glass filler

    T Itota, OT Al-Naimi, TE Carrick, M Yoshiyama, JF McCabe

    DENTAL MATERIALS   21 ( 11 )   1033 - 1038   2005.11

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    Objectives: The aim of this study was to evaluate the fluoride release from aged resin composites containing different types of fluoridated glass filter into both deionized distilled water and lactic acid sotution.
    Methods: Three resin composites, UniFil S (containing fluoro-alumino-silicate glass filter), Reactmer (containing pre-reacted glass-ionomer filter) and Beautifil (containing both types of filters) were used. A conventional glass-ionomer cement, Ketac-Fit, was used as a controt. Five disk specimens of each material were prepared and aged in water for 10 weeks. After aging, specimens were immersed in deionized distilled water for a further 6 days and then in aqueous tactic acid (pH 4.0) for 2 days. This process was repeated twice more and the specimens were subsequently immersed in water for a further 12 days. Fluoride release was measured every 2 days throughout the post-aging period.
    Results: The amount of fluoride release for aged UniFil S and Beautifil markedly increased in acid solution compared with water storage. The difference was not so great for aged Reactmer and Ketac-Fil. UniFit S and Beautifil gave significantly greater fluoride release in water following immersion in acid solution (p&lt; 0.05, two-way ANOVA and Scheffe's test), but Reactmer and Ketac-Fil showed no such increase in fluoride release after acid immersion.
    Significance: These results suggested that the nature of the fluoridated glass filter within a resin composite and the way in which the material interacts with an acidic environment affected the amount of fluoride released. (c) 2005 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

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  • Effects of resin hydrophilicity on water sorption and changes in modulus of elasticity

    S Ito, M Hashimoto, B Wadgaonkar, N Svizero, RM Carvalho, C Yiu, FA Rueggeberg, S Foulger, T Saito, Y Nishitani, M Yoshiyama, FR Tay, DH Pashley

    BIOMATERIALS   26 ( 33 )   6449 - 6459   2005.11

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    As acidic monomers of self-etching adhesives are incorporated into dental adhesives at high concentrations, the adhesive becomes more hydrophilic. Water sorption by polymers causes plasticization and lowers mechanical properties. The purpose of this study was to compare the water sorption and modulus of elasticity (E) of five experimental neat resins (EX) of increasing hydrophilicity, as ranked by their Hoy's solubility parameters and five commercial resins.
    Methods: After measuring the initial modulus of all resin disks by biaxial flexure, half the specimens were stored in hexadecane and the rest were stored in water. Repeated measurements of stiffness were made for 3 days. Water sorption and solubility measurements were made in a parallel experiment.
    Results: None of the specimens stored in oil showed any significant decrease in modulus. All resins stored in water exhibited a time-dependent decrease in modulus that was proportional to their degree of water sorption. Water sorption of EX was proportional to Hoy's solubility parameter for polar forces (delta(p)) with increasing polarity resulting in higher sorption. The least hydrophilic resin absorbed 0.55 wt% water and showed a 159110 decrease in modulus after 3 days. The most hydrophilic experimental resin absorbed 12.8wt% water and showed a 73% modulus decrease during the same period. The commercial resins absorbed between 5% and 12% water that was associated with a 19-42% reduction in modulus over 3 days. (c) 2005 Elsevier Ltd. All rights reserved.

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  • Fluoride release and neutralizing effect by resin-based materials

    T Itota, OT Al-Naimi, TE Carrick, M Yoshiyama, JF McCabe

    OPERATIVE DENTISTRY   30 ( 4 )   522 - 527   2005.7

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    This study evaluated the fluoride-releasing and neutralizing abilities of resin-based materials containing fluoride in water and aqueous lactic acid. Two composites, containing a low-solubility fluoride component (Heliomolar) and a fluoro-alumino-silicate glass (UniFil S), and two giomers, containing surface reaction type pre-reacted glass-ionomer filler (Beautifil) and full reaction type glass-ionomer filler (Reactmer paste), were used. Resin-modified glass-ionomer cement (Fuji II LC) was used as a control. The fluoride release and pH value in storage medium, after immersion in each material, was measured for 10 weeks. For UniFil S and Beautifil, the amount of fluoride released in acid solution markedly increased compared to storage in water (p&lt;0.05). Although all materials, except Heliomolar, neutralized the storage media, the neutralizing ability of these resin-based materials in acid solution sharply decreased with aging of the specimens, except for Fuji II LC. These results suggest that the nature of fluoride incorporated into resin-based materials affect the fluoride-releasing and neutralizing ability of materials in water and aqueous lactic acid.

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  • Effect of two-step adhesive systems on inhibition of secondary caries around fluoride-releasing resin composite restorations in root dentine

    T Itota, S Nakabo, T Narukami, Y Tashiro, Y Torii, JF McCabe, M Yoshiyama

    JOURNAL OF DENTISTRY   33 ( 2 )   147 - 154   2005.2

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    Objective. The purpose of this study was to investigate the effect of two-step adhesive systems on secondary caries inhibition around fluoride-releasing materials in vitro.
    Methods. Two self-etching primer systems, Clearfil SE Bond (SE) and UniFil Bond (UB), and two one-bottle systems with a totat-etch wet-bonding technique, Single Bond (SB) and One-Step (OS), were used prior to placement of resin composites either with (Reactmer) or without (Z100) fluoride release. Class V cavities prepared in extracted human premolars were restored with various combinations of materials: Reactmer/SE, Reactmer/UB, Reactmer/SB, Reactmer/OS, Z100/SE, Z100/UB, Z100/SB and Z100/OS. After storage for 14 days, the restored teeth were incubated in bacterial medium containing sucrose with Streptoccus mutans for 2 weeks. Water sorption and desorption of the adhesives and fluoride release from the resins either coated with adhesive or uncoated were also determined.
    Results. The one-bottle groups showed higher water sorption and desorption than the self-etching primer groups. Although fluoride release from the Reactmer specimens was suppressed by the adhesive coating, the one-bottle groups allowed significantly higher fluoride release than the self-etching primer groups. On microradiographs, the radio-opaque layers adjacent to the Reactmer restorations were thick and clear, white the layers adjacent to the Z100 restorations were thin and unclear. For the Reactmer restorations, the radio-opaque Layers associated with the one-bottle groups were significantly thicker than for the self-etching primer groups.
    Conclusions. These results indicated that the use of one-bottle wet-bonding systems for bonding of fluoride-releasing resin composites to dentine may contribute to inhibit secondary caries compared to self-etching primer systems. (C) 2004 Elsevier Ltd. All rights reserved.

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  • Water content and apparent stiffness of non-caries versus caries-affected human dentin

    S Ito, T Saito, FR Tay, RM Carvalho, M Yoshiyama, DH Pashley

    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS   72B ( 1 )   109 - 116   2005.1

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    Caries-affected dentin contains less mineral and more water than surrounding normal dentin. Such dentin should be less stiff and should shrink more than normal dentin when dried. The purpose of this study was to test the relationships between the stiffness, shrinkage, and water content of caries-affected versus normal dentin. Extracted human carious third molars were stained with caries-detector dye and the occlusal surfaces ground down until only caries-affected dentin remained, surrounded by normal dentin. Dentin disks were prepared from these crowns placed in a aluminum well positioned under a modified thermal mechanical analyzer. Changes in specimen height and stiffness were measured following drying or static loading in both caries-affected and surrounding normal dentin. Core samples of these two types of dentin were used to gravimetrically measure water content. Two-way ANOVA and regression analysis was used to test the relationship between shrinkage versus water content, stiffness versus water content, and stiffness versus shrinkage. Caries-affected dentin was found to be less stiff and contained more water than normal dentin (p &lt; 0.05). Regression analysis revealed highly significant inverse relationships between stiffness and water content, and stiffness and shrinkage (p &lt; 0.0005). (C) 2004 Wiley Periodicals, Inc.

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  • 文献と臨床の橋わたし --フッ素徐放性材料は二次齲蝕抑制が可能か?--.

    糸田俊之, 吉山昌宏

    日本歯科評論   65,11,187-189   2005

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  • Distribution of calbindin D-28k in odontoblasts after cavity preparation in human teeth.

    Tashiro Y, Itota T, Takagi R, Shinno Y, Yoshiyama M

    Journal of Oral Tissue Engineering   2005

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  • Effects of multiple coatings of two all-in-one adhesives on dentin bonding

    Shuichi Ito, Franklin R. Tay, Masanori Hashimoto, Masahiro Yoshiyama, Takashi Saito, William W. Brackett, Jennifer L. Waller, David H. Pashley

    Journal of Adhesive Dentistry   7 ( 2 )   133 - 141   2005

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    Purpose: Simple changes to bonding technique can improve resin-dentin bond strengths. The objective of this study was to evaluate the effects of multiple coatings of two all-in-one adhesive resins on both microtensile bond strength (μTBS) and nanoleakage. Materials and Methods: The mid-coronal occlusal dentin of extracted human molars was used. Two all-in-one adhesives - iBond (Heraeus Kulzer) and Xeno III (Caulk Dentsply) - were applied to 320-grit abraded dentin surfaces. In groups 1 and 3 during bonding, monomer application and solvent evaporation were done 1, 2, 3, 4 or 5 times on the dentin surface before light curing. In groups 2 and 4 after light curing the first layer, the adhesive was re-applied, the solvent evaporated, and the layer light cured. This was repeated from 2 to 5 times, followed by creation of composite buildups. After 24 h storage in 37°C water, the teeth were sectioned perpendicular to the adhesive interface to produce multiple beams of composite-bonded dentin, approximately 0.9 mm2 in area. These were tested to failure in tension. Data were evaluated by three-way ANOVA (material vs coatings vs light curing) followed by multiple comparisons at α = 0.05. Additionally, nanoleakage of silver uptake and adhesive layer thickness were evaluated using transmission electron microscopy (TEM). The results indicated that bond strengths increased with the number of coatings (p &lt
    0.0001) with both adhesives, up to 3 layers, especially if each layer was light cured. Nanoleakage of silver tended to decrease with each coat in both adhesive systems. Conclusion: By simply applying more coats of adhesive, the strength and quality of dentin adhesion can be improved.

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  • 接着を活かせば歯は長持ちするか 脱灰象牙質再石灰化能を有する接着システムが開発される.

    吉山昌宏

    デンタルダイヤモンド   30,1,42-43   2005

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  • セルフエッチングプライマー接着システムの歯面処理時間短縮が歯質接着性に及ぼす影響.

    高畑安光, 糸田俊之, 土居潤一, 田中久美子, 西谷佳浩, 吉山昌宏

    接着歯学   2005

  • ワンボトルワンステップ接着システムの脱灰象牙質への接着性.

    高畑安光, 山本香穂里, 土居潤一, 高木 了, 田代陽子, 宇城直樹, 糸田俊之, 吉山昌宏

    日本歯科保存学雑誌   2005

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  • 文献と臨床の橋わたし --象牙質接着の評価法を考える--.

    西谷佳浩, 吉山昌宏

    日本歯科評論   65,12,185-187   2005

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  • 文献と臨床の橋わたし --一般臨床家の行うミニマルインターベンション--.

    吉山昌宏

    日本歯科評論   65,10,177-179   2005

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  • Effect of 2-hydroxyethyl methacrylate pre-treatment on micro-tensile bond strength of resin composite to demineralized dentin

    J Doi, T Itota, Y Torii, S Nakabo, M Yoshiyama

    JOURNAL OF ORAL REHABILITATION   31 ( 11 )   1061 - 1067   2004.11

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    The purpose of this study was to evaluate the effect of 2-hydroxyethyl methacrylate (HEMA) application on the micro-tensile bond strength of resin composite to demineralized dentin. Artificially demineralized lesions were formed on bovine dentin surfaces and treated with 10, 30, 50, 70 and 100 wt% HEMA aqueous solution. The surfaces were then applied and covered with SE Bond and AP-X according to the manufacturer's instruction. After immersion in 37 degreesC water for 24 h, bond strength were measured using a universal testing machine. Bond strengths to both demineralized dentin and normal dentin, without HEMA application, were also measured. Scanning electron microscopic (SEM) observation and confocal laser scanning microscopy (CLSM) analysis at the resin-dentin interface were also performed. The bond strength data were statistically compared with ANOVA and Scheffe's test (P &lt; 0.05). Bond strength to demineralized dentin treated with over 30 wt% HEMA aqueous solution were significantly higher than that to demineralized dentin without HEMA application, but significantly lower than that to normal dentin. SEM observation revealed that the hybrid layer and resin-tags thickened and lengthened with HEMA application. In CLSM, the diffusion of adhesive primer into demineralized dentin increased with HEMA application. These results indicated that HEMA application might increase the bond strength to demineralized dentin by the enhancement of resin monomer penetration of HEMA.

    DOI: 10.1111/j.1365-2842.2004.01338.x

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  • Fluoride release and recharge in giomer, compomer and resin composite

    T Itota, TE Carrick, M Yoshiyama, JF McCabe

    DENTAL MATERIALS   20 ( 9 )   789 - 795   2004.11

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    Objectives. The aim of this study was to examine the fluoride recharging and releasing abilities of resin-based materials containing fluoridated glass filler to determine whether the extent of the glass-ionomer matrix of the material affects these properties.
    Methods. Three materials having a different proportion of the hydrogel matrix surrounding the glass filler, namely: Reactmer paste, Dyract AP and Xeno CF, were used for this study. Five disk specimens of each material were placed into distilled/ deionized water and the fluoride release measured during 38 days. For fluoride recharge the disks were exposed to 250 ppm F solution for 1 h and the pre- and post-recharge fluoride release were determined using an ion-selective electrode (total fluoride ions) and ion chromatography (free fluoride ions).
    Results. The amounts of total and free fluoride release from each material at the initial period in descending order were Reactmer paste &gt; Dyract AP &gt; Xeno CF (p &lt; 0.05, ANOVA and Scheffe's test). After fluoride recharge, Reactmer paste showed a greater amount of fluoride release than the other materials. Dyract AP and Xeno CF showed a similar total level of fluoride release after recharging. For Xeno CF the amount of total fluoride released after recharging was significantly greater than that of free fluoride, but there was no significant difference between total and free fluoride released after recharging for Dyract AP (p = 0.05, paired t-test).
    Significance. These results suggested that the extent of the glass-ionomer matrix of the glass filler played an important role for fluoride-releasing and recharging abilities of the resin-based materials. (C) 2004 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.dental.2003.11.009

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  • Micro-tensile bond strength of self-etching primer adhesive systems to human coronal carious dentin

    J Doi, T Itota, Y Torii, S Nakabo, M Yoshiyama

    JOURNAL OF ORAL REHABILITATION   31 ( 10 )   1023 - 1028   2004.10

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    The aim of this study was to evaluate the micro-tensile bond strengths of three self-etching primer adhesive systems to normal dentin (ND), caries-affected dentin (CAD) and caries-infected dentin (CID). Human extracted molars with caries were used, and flat dentin surfaces ground by 600-grit SiC paper were prepared. The surfaces were dyed using Caries-Detector solution, treated with Clearfil SE Bond, Mac-Bond II and UniFil Bond, and then covered with resin composites according to manufacturer's instructions. After immersion in 37degreesC water for 24 h, the teeth were serially sectioned into multiple slices. Each slice was distinguished into ND, CAD and CID groups by the degree of staining, and the bond strength was measured in a universal testing machine. Scanning electron microscopic (SEM) observation was also performed. For statistical analysis, ANOVA and Scheffe's test were used (P &lt; 0.05). The bond strengths of the three adhesive systems to CAD and CID were significantly lower than those to ND. There was significant difference in the bond strength to ND between Clearfil SE Bond and UniFil Bond, but no significant differences to CAD and CID among the three adhesive systems. On SEM, the hybrid layers in CAD and CID showed more porous structures compared with ND. The results indicated that the bond strengths to CAD and CID were not affected by a variety of self-etching primer adhesive systems because of the porous hybrid layer formation in carious dentin.

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  • Nanoleakage types and potential implications: Evidence from unfilled and filled adhesives with the same resin composition

    FR Tay, DH Pashley, C Yiu, C Cheong, M Hashimoto, K Itou, M Yoshiyama, NM King

    AMERICAN JOURNAL OF DENTISTRY   17 ( 3 )   182 - 190   2004.6

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    Purpose: To compare nanoleakage patterns of an unfilled (OS; One-Step), a 6 wt% spherical silica-filled (OSs; One-Step Plus) and a 15 wt% glass-filled (OSg) version of a two-step, acetone-based self-priming adhesive. Permeability of bonded dentin treated with OS and OSs was also examined. Methods: Deep, coronal dentin from extracted third molars were etched and bonded using these adhesives. One-mm thick sections were immersed in 50 wt% ammoniacal silver nitrate (pH 9.5) for 24 hours. Unstained, undernineralized sections were examined by TEM. The permeability of dentin bonded with OS and OSs were investigated at 20 cm of H2O hydrostatic pressure and compared with the osmotic conductance determined with 4.8 M CaCl2 at zero hydrostatic pressure. Composite-dentin beams bonded with OS, OSs and OSg that were fractured after microtensile bond testing were examined by SEM. Results: Two types of nanoleakage patterns were recognized along the resin-dentin interfaces. The reticular type consisted of discontinuous islands of silver deposits and was exclusively seen in hybrid layers. The spotted type consisted of isolated silver grains and was evident throughout the hybrid and adhesive layers in OS. These two patterns were seen to variable extents in the two filled adhesive versions OSs and OSg and their distribution was independent of one another. OS and OSs bonded dentin were permeable to fluid filtration. However, part of this fluid movement was due to the permeability of the adhesive layer, as demonstrated by osmotic fluid conductance in the absence of hydrostatic pressure. Fractographic analysis revealed denuded collagen fibrils within fractured hybrid layers that were indicative of incomplete resin infiltration.

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  • Bonding to root caries by a self-etching adhesive system containing MDPB

    JC Doi, T Itota, M Yoshiyama, FR Tay, DH Pashley

    AMERICAN JOURNAL OF DENTISTRY   17 ( 2 )   89 - 93   2004.4

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    Purpose: To evaluate the bonding of an experimental antibacterial fluoride-releasing adhesive system (ABF) to normal and carious dentin in human teeth with Class V root caries. Methods: Mesiodistal sectioning removed the buccal enamel, superficial dentin and much of the carious dentin in 21 extracted human bicuspids with root surface caries. The surfaces of normal coronal and root dentin, and caries-affected and caries-infected dentin were ground with wet 600-grit SiC paper to create a standardized smear layer. Tooth surfaces were treated with the ABF according to manufacturer's instructions, and then covered with excess resin composite. After immersion in 37 C water for 24 hours, the restored teeth were horizontally sectioned into serial slabs that were trimmed into hourglass shapes to isolate the bonded area to the test substrates, and then their bond strengths were measured by the microtensile bond test, and the interfaces examined by SEM and TEM. The bond strengths were statistically compared with ANOVA and Fisher's PLSD (P&lt; 0.05). Results: The bond strengths of ABF to caries-affected and caries-infected dentin were significantly lower than those to normal coronal and root dentin. SEM micrographs revealed that the hybrid layers in caries-affected and caries-infected-dentin were more porous compared to the hybrid layer in normal coronal and root dentin. TEM micrographs showed that bacteria that had invaded the dentin were embedded in this adhesive monomer in caries-infected dentin.

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  • An Association of Communication Skills Competencies among OSCE Stations

    YOSHIDA Toshiko, MIYAWAKI Shouichi, ARAI Hideo, TORII Yasuhiro, ARAKAWA Hikaru, SHIMONO Tsutomu, YOSHIYAMA Masahiro, NAGAI Noriyuki

    日本歯科医学教育学会雑誌 = Journal of Japanese Association for Dental Education   19 ( 2 )   332 - 342   2004.3

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    異なる課題においてのコミュニケーション技能の評価を検討する目的で,平成14年度の岡山大学歯学部Objective Structured Clinical Examination(OSCE)トライアルにおいて,初診時の医療面接(1つのステーション)と病状説明(2つのステーション)を設定し,内容とプロセス領域を含んだ評価項目を作成して試験を実施した.はじめに評価者間の評価の差を検討し,次に3つの課題間においてコミュニケーションの2つの構成領域ごとに関連性があるのかを検討した.また,課題ごとにそれぞれ,内容領域とプロセス領域の関連性も検討した.課題が異なれば,その課題内容に特異的な知識については差があるが,コミュニケーション技能に関しては,課題設定が異なっても共通した技能である可能性が示唆された

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  • Determination of fluoride ions released from resin-based dental materials using ion-selective electrode and ion chromatograph

    T Itota, TE Carrick, S Rusby, OT Al-Naimi, M Yoshiyama, JF McCabe

    JOURNAL OF DENTISTRY   32 ( 2 )   117 - 122   2004.2

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    Objectives. The aim of this study was to investigate the quantities of total and free fluoride ions released from four resin-based composites containing fluoride (Heliomolar (HE), UniFil S (UF), Beautifil (BE) and Reactmer paste (RP)) and one glass ionomer cement (Ketac-Fil Plus Aplicap (KF)).
    Methods. Five disk specimens of each material were prepared and the fluoride release was measured at 1, 2, 4, 7, 14, 21 and 28 days. The amounts of total and free fluoride ions released from materials were measured by using an ion-selective electrode (ISE) and ion chromatography (IC). Data were statistically analyzed using a t-test at a significant level of 0.05.
    Results. For HE, fluoride release is undetectable using the ISE but was detected by the IC method. There were no significant differences in the free and total fluoride ions released from UF and BE (p &gt; 0.05). For RP, the free fluoride ions were significantly lower than the total fluoride ions after 4 days (p &lt; 0.05). KF showed significant difference between total and free fluoride ions at 7 and 28 days (p &lt; 0.05).
    Conclusions. The nature of the fluoride incorporated into dental materials affected the amounts of free and total fluoride ions released from materials. (C) 2003 Elsevier Ltd. All rights reserved.

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  • Calbindin D-28k distribution in odontoblasts underneath tertiary dentine in human carious teeth

    T Itota, Y Tashiro, Y Torii, Y Nishitani, JF McCabe, M Yoshiyama

    ARCHIVES OF ORAL BIOLOGY   49 ( 1 )   37 - 43   2004.1

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    Objective: The aim of this study was to examine the calbindin D-28k immunoreactivity in carious teeth to know whether this protein may have a function in tertiary dentine formation. Methods: Human extracted teeth with or without carious lesions were immersion-fixed with Zamboni fixative, demineralized in 4.13% EDTA solution (pH 7.4), frozen-sectioned, and processed for calbindin immunoreactivity and hematoxylin-eosin stain. The intensity of the immunostaining was evaluated by quantitative densitometry. Results: In intact teeth, numerous odontoblasts were aligned underneath the secondary dentine and their cell bodies showed the immunoreactivity. In carious teeth, tertiary dentine had poor- or rich tubular patterns under the carious lesion. Underneath the tubule-poor tertiary dentine, distinct odontoblasts could not be seen at the central site. However, some cells with a flat appearance were located at this site and were immunonegative for calbindin D-28k. On the other hand, columnar odontoblasts were seen at the peripheral site, and their cell bodies and processes showed strong immunoreactivity. Underneath the tubule-rich tertiary dentine, columnar odontoblasts were abundantly distributed, and the strong immunoreactivity was observed in their cell bodies and processes. The immunoreactivity in odontoblasts underneath the tertiary dentine with poor or rich tubular pattern was more intense than that for the secondary dentine in intact teeth (P &lt; 0.05). On the other hand, the intensity of the immunoreactivity in odontobtasts was similar underneath the secondary dentine in intact and carious teeth. Conclusions: The present study demonstrated that calbidin D-28k was actively synthesised by odontobtasts under the carious lesion. These findings may suggest that this protein plays an important rote in the tertiary dentine formation. (C) 2003 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/S0003-9969(03)00183-3

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  • Dentin regeneration and reconstruction: comparison of in vivo vs. in vitro dentin bonds with self-etching/self-priming adhesive systems.

    Shimizu H, Yoshiyama M, Nishitani Y, Ando N, Pashley DH

    Journal of Oral Tissue Engineering   2004

  • Modified sealed restoration and the development of dentin regeneration therapy.

    Yoshiyama M, Shimizu H, Nishitani Y, Itota T, Pashley DH

    Journal of Oral Tissue Engineering   2004

  • Bonding ability of adhesive resins to caries-affected and caries-infected dentin.

    Yoshiyama M, Doi J, Nishitani Y, Itota T, Tay FR, Carvalho RM, Pashley DH

    Journal of Applied Oral Science   12,3,171-176   2004

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  • 4種類のポストコアシステムで築造した歯内処置前歯の破折に対する抵抗性について.

    原著者, Hu YH, Pang LC, Hsu CC, Lau YH, 抄訳者, 高畑安光, 鳥井康弘, 吉山昌宏

    The Quintessence   23,6,159-163   2004

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  • 1ステップ接着システム その現状と課題.

    吉山昌宏

    The Quintessence   23,11,79-83   2004

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  • コラーゲン固定化エチレン-ビニルアルコール共重合体(EVA)のヒト歯髄由来細胞に対する影響.

    西谷佳浩, 高木 了, 宇城直樹, 糸田俊之, 玄 丞烋, 堤 定美, 吉山昌宏

    日本再生歯科医学会誌   2004

  • 審美修復用レジンセメントの象牙質接着性.

    吉山昌宏, 西谷佳浩

    歯科審美   2004

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  • 水酸化カルシウムペーストが根管象牙質への接着強さに及ぼす影響.

    西谷佳浩, 西谷登美子, 糸田俊之, 高畑安光, 吉山昌宏

    接着歯学   2004

  • 試作再石灰化溶液の象牙質接着に及ぼす影響.

    西谷佳浩, 高橋和宏, 西谷登美子, 安藤菜美子, 高橋 圭, 山本香穂里, 宇城直樹, 糸田俊之, 高畑安光, 清水洋利, 鳥井康弘, 吉山昌宏

    日本歯科保存学雑誌   2004

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  • 窩洞形成時疼痛の中枢抑制機構の解明-ラット最後野におけるドーパミン受容体の局在-.

    伊澤俊次, 高木 了, 土居潤一, 仲保 聡, 高畑安光, 西谷登美子, 西谷佳浩, 高務朋将, 清水洋利, 糸田俊之, 鳥井康弘, 吉山昌宏

    日本歯科保存学雑誌   2004

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  • Dentin phosphophoryn accelerates rhBMP-2/HAP-induced bone formation.

    Saito T, Kobayashi F, Izumikawa M, Koike T, Yoshiyama M, Uemura T, Bessho K

    Journal of Oral Tissue Engineering   2004

  • 次世代の接着[3]米国接着歯学の流れとその将来.

    Pashley D, Tay F, 吉山昌宏

    The Quintessence   23,3,68-74   2004

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  • 次世代の接着 象牙質再生をめざす接着性レジン.

    吉山昌宏, 仲保 聡, 西谷佳浩, 糸田俊之

    The Quintessence   23,6,53-58   2004

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  • 歯科臨床次の一手 歯科の最新テクノロジー う蝕治療に果すボンディング材の役割.

    西谷佳浩, 高橋 圭, 安藤菜美子, 吉山昌宏

    デンタルダイヤモンド   29,9,61-65   2004

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  • 破折歯症候群の診断,治療と予防.

    原著者, Geurtsen W, Schwarze T, G?nay H, 抄訳者, 伊澤俊次, 鳥井康弘, 吉山昌宏

    The Quintessence   23,6,151-158   2004

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  • Effect of EDTA conditioning on bond strength to bovine dentin promoted by four current adhesives

    Y Torii, R Hikasa, S Iwate, F Oyama, K Itou, M Yoshiyama

    AMERICAN JOURNAL OF DENTISTRY   16 ( 6 )   395 - 400   2003.12

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    Purpose: To investigate the effect of disodium dihydrogen ethylenediamine tetraacetate dihydrate (EDTA) conditioning prior to the application of adhesive systems on the bond strength of resin composite to dentin. Methods: 80 bovine teeth were ground with 600-grit SiC paper to obtain flat dentin surfaces. Half of the specimens were conditioned with 0.5 mol EDTA aqueous solution (pH 7.4) for 60 seconds, water-rinsed and air-dried, and the other half were used without any treatment. The specimens were randomly divided in four groups of 10 each. The dentin surfaces were treated with each of two "all-in-one" adhesive systems (One-up Bond F, OB; Reactmer Bond, RB), a self-etching priming system (Clearfil SE Bond, SE), and a total-etch one-bottle bonding system (Single Bond, SB). For SB, the adhesive was applied on EDTA-conditioned dentin without H3PO4 etching. Then a layer of resin composite was placed and light-cured for 40 seconds. The tensile bond strength was measured and the resin-dentin interface was observed using a scanning electron microscope. Results: The mean and standard deviation of tensile bond strength in MPa to ground dentin were 9.3 +/- 3.5/OB, 11.6 +/- 2.0/RB, 23.2 +/- 4.9/SE and 19.7 +/- 4.1/SB. Bond strengths to EDTA-conditioned dentin were 15.0 +/- 3.0/OB, 16.8 +/- 3.6/RB, 22.8 +/- 5.2/SE and 19.4 +/- 5.1/SB. Duncan's Multiple Range test revealed that the EDTA-conditioned dentin showed significantly higher tensile bond strength than the non-conditioned one for "all-in-one" adhesive systems (P &lt; 0.05) but no significant difference was found for the self-etching priming and total-etch one-bottle bonding systems. At the resin-dentin interface, EDTA-conditioned specimens formed thicker hybrid layers than non-conditioned ones for all systems except for SB.

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  • Viscoelastic properties of demineralized dentin matrix

    DH Pashley, KA Agee, JC Wataha, F Rueggeberg, L Ceballos, K Itou, M Yoshiyama, RM Carvalho, FR Tay

    DENTAL MATERIALS   19 ( 8 )   700 - 706   2003.12

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    Objectives. To evaluate the viscoelastic properties of demineralized dentin matrix. Stress-relaxation studies were done on matrices in tension and strain elongation or creep studies were done in both tension and compression.
    Methods. Mid-coronal dentin disks were prepared from extracted unerupted human third molars. Disks were 0.5 mm thick for stress-relaxation or tensile creep experiments and 0.2-0.3 mm thick for compressive creep studies. 'I' beam specimens were prepared from dentin disks and the middle region was demineralized in 0.5 M EDTA (pH 7) for 4 days. The specimens were held in miniature friction grips in water and pulled at 100 mum s(-1) to strains of 5, 10, 15 or 20% and then held for 10 min to follow the decay of stress over time. Creep was determined on demineralized dentin immersed in water in tension and in compression. Compressive creep was measured using an LVDT contact probe with loads of 0.02-0.5 N. Strain data were converted to compliance-time curves (strain/stress) and expressed as total compliance (J(t)), instantaneous elastic compliance (J(o)), retarded elastic compliance (J(R)) and viscous response (t/eta) or creep.
    Results. The dentin matrix exhibits both stress-relaxation and creep behavior. Stress-relaxation and tensile creep were independent of strain but compressive creep rates were inversely related to compressive strain.-Creep values were about 10% at low compressive strains, but fell progressively to 1% at high strains. Compliance-time curves fell with stress and came closer together. However, tensile creep was about 3% regardless of the strain.
    Significance. The dentin matrix exhibits viscoelastic properties, but is not linearly. viscoelastic. The relatively high creep rates of the matrix under low compressive loads may cause viscous deformations in poorly infiltrated hybrid layers in resin-bonded teeth under function. 2003 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

    DOI: 10.1016/S0109-5641(03)00016-2

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  • Immunocytochemical localization of dopamine receptors in rat area postrema

    S Izawa, T Yamada, S Nakabo, J Doi, Y Nishitani, T Takatsuka, T Itota, H Shimizu, Y Torii, M Yoshiyama

    JOURNAL OF DENTAL RESEARCH   82   426 - 426   2003.12

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:INT AMER ASSOC DENTAL RESEARCHI A D R/A A D R  

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  • Effect of drying methods on hybrid layer thickness

    K Itou, Y Torii, F Oyama, M Yoshiyama, DH Pashley

    AMERICAN JOURNAL OF DENTISTRY   16 ( 5 )   335 - 339   2003.10

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    Purpose: To evaluate the effect of drying methods used in scanning electron microscopy on the thickness of the hybrid layers created by several different adhesive systems. Methods: A total etch dry bonding system, (Photobond), a three-step bonding adhesive system, (Scotchbond Multi-Purpose), a wet-bonding adhesive system (All-Bond 2) and a self-etching primer system (Mac Bond II) were used in this study. To permit measurement of the thickness of the hybrid layer, the resin-dentin interfaces were polished and etched briefly to remove polishing debris followed by immersion in 10% NaOCl for 4 hours. Half of the specimens in each group were subjected to fixation and critical-point drying followed by gold sputter-coating. The remaining specimens were allowed to air dry prior to gold sputter-coating. SEM observations were carried out to determine the structure and thickness of the hybrid layers. Results: The thickness of hybrid layers were affected by the drying methods with the critical-point drying methods producing the thickest hybrid layers (P&lt; 0.05). The thickest hybrid layers were created by Photobond, with Scotchbond Multi-Purpose and All-Bond 2 producing intermediate thickness hybrid layers, among the total etch systems. The thinnest hybrid layer among all of the adhesive systems was produced by the self-etching primer, Mac Bond II.

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  • Sealing properties of a self-etching primer system to normal caries-affected and caries-infected dentin

    KW Lee, HH Son, M Yoshiyama, FR Tay, RM Carvalho, DH Pashley

    AMERICAN JOURNAL OF DENTISTRY   16   68A - 72A   2003.9

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    Purpose: To compare the ability of an experimental antibacterial self-etching primer adhesive system to seal exposure sites in normal, caries-affected and caries-infected human dentin. Methods: 30 extracted human third molars were used within 1 month of extraction. 10 intact normal teeth comprised the normal group. 20 teeth with occlusal caries that radiographically extended halfway to the pulp were excavated using caries-detector solution (CDS) and a #4 round carbide bur in a slowspeed handpiece. Half of those teeth were fully excavated free of CDS-stained material without exposing the pulp, and were designated as the caries-affected dentin group. The remaining 10 teeth were excavated as close to the pulp as possible without obtaining an exposure, but whose dentin continued to stain red with CDS; this group was designated as the caries-infected dentin group. The remaining dentin thickness in all of the specimens in the other two groups was then reduced to the same extent as the caries-infected group. Direct exposures of the pulp chamber were made with a 1/4 round bur in the normal dentin or a 25 gauge needle in the other two groups. After measuring the fluid flow through the exposure, the sites were then sealed with an experimental antibacterial fluoride-containing self-etching primer adhesive systems (ABF). Fluid conductance was remeasured every week for 16 weeks. Results: The fluid conductance through the exposure fell 99% in all groups following resin sealing. The seals of normal and caries-affected dentin remained relatively stable over the 16 weeks, while the seals of caries-infected dentin gradually deteriorated, reaching significance at 8 weeks. TEM examination revealed very thin (ca. 0.5 mm) hybrid layers in normal dentin, 3-4 mum thick hybrid layers in caries-affected dentin and 40 mum thick hybrid layers in caries-infected dentin. The tubules of caries-infected dentin were enlarged and filled with bacteria. Resin tags passed around these bacteria in the top 20-40 mum thereby encapsulating them in resin.

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  • Confocal laser scanning microscopic analysis of early plaque formed on resin composite and human enamel

    N Konishi, Y Torii, A Kurosaki, T Takatsuka, T Itota, M Yoshiyama

    JOURNAL OF ORAL REHABILITATION   30 ( 8 )   790 - 795   2003.8

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    The purpose of this study was to analyse quantitatively the early bacterial plaque formed on resin composite and human enamel in vivo , using a confocal laser scanning microscope. Test pieces of resin composite and human enamel were retained at the buccal surfaces of the upper first molars of three volunteers for 4, 8 and 24 h to allow plaque formation. Then, the specimens were immersed in propidium iodide in phosphate-buffered saline to stain adherent bacteria and observed with a confocal laser scanning microscope. The ratios of the area occupied by microorganisms to the whole area of the optical field were calculated using a photo-image analysis system. The thickness of the plaque was also measured. Quantitative analysis revealed that the resin composite showed significantly higher bacterial adherence than human enamel throughout the test period. A difference was noticed in the morphology of the bacteria between the two groups. Our findings suggest that resin composite shows higher bacteria adherence during early plaque formation compared with human enamel. In addition, the present findings may suggest a presence of the difference in bacterial composition of plaque in both specimens.

    DOI: 10.1046/j.1365-2842.2003.01129.x

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  • Effect of self-etching primer containing N-acryloyl aspartic acid on enamel adhesion

    Y Torii, K Itou, Y Nishitani, M Yoshiyama, K Ishikawa, K Suzuki

    DENTAL MATERIALS   19 ( 4 )   253 - 258   2003.6

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    Objectives: A previous study demonstrated that N-acryloyl aspartic acid (N-AAsp) aqueous solution is useful as a self-etching primer for dentin adhesion. The purpose of this study was to evaluate whether N-AAsp solution can be used for enamel etching, when compared with phosphoric acid.
    Methods: N-AAsp was synthesized by the reaction of DL-aspartic acid and acryloyl chloride. The experimental self-etching primers were prepared by dissolving N-AAsp in water at various concentrations up to 20 wt%. The tensile bond strength of resin to bovine enamel was measured after the enamel was treated with the N-AAsp primers. The 40 wt% H3PO4 was used for comparison. The treated enamel surfaces and the resin-enamel interfaces were also observed with a scanning electron microscope.
    Results: The tensile bond strength to enamel increased linearly with the increasing N-AAsp concentration and reached the same value as that to enamel etched with 40 wt% H3PO4 when N-AAsp concentration was 20 wt%, even though the etching ability of 20 wt% N-AAsp was inferior to 40 wt% H3PO4. Regardless of the concentration of N-AAsp, the bond strength to,enamel was the same as that to dentin reported in our previous study.
    Significance: The 20 wt% N-AAsp aqueous solution showed enamel bonding equivalent to 40 wt% H3PO4 in addition to the advantage of eliminating the rinse step with water. Based on the results obtained in this study along with those obtained in a previous study, it was concluded that 20 wt% N-AAsp aqueous solution is a promising self-etching primer to simultaneously treat enamel and dentin. (C) 2003 Academy of Dental Materials. Published by Elsevier Science Ltd. All rights reserved.

    DOI: 10.1016/S0109-5641(02)00028-3

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  • Bonding of all-in-one adhesive systems to carious dentin.

    Y. Nishitani, T. Yamada, K. Takahashi, T. Itota, H. Shimizu, M. Yoshiyama, D. H. Pashley

    JOURNAL OF DENTAL RESEARCH   82   B52 - B52   2003.6

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  • Development of the Dentin Regeneration Therapy : Effect of alginate gel to human cultured dental pulp cells

    SHIMIZU Hirotoshi, NISHITANI Yoshihiro, YAMADA Tomiko, TAKAHASHI Kazuhiro, TAKEMASA Eisaku, YAMAUCHI Junichi, YOSHIYAMA Masahiro

    46   53 - 53   2003.5

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  • Bonding of single component self-etching adhesive to dentin Early adhesive property to normal vs. caries-affected dentin

    SHINJO Ayano, YOSHII Satoko, NISHITANI Yoshihiro, TAKAHASHI Kazuhiro, YAMADA Tomiko, TORII Yasuhiro, YOSHIYAMA Masahiro, FUJIWARA Satoshi, ODA Naoki

    46   67 - 67   2003.5

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  • Treatment of fracture of Laminate Veneer

    SHIMIZU Hirotoshi, NISHITANI Yoshihiro, YOSHIYAMA Masahiro

    46   169 - 169   2003.5

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  • Diffusion of Adhesive resin into Intact and Carious Dentin

    OTSUKI Haruka, ARATA Masami, YAMAMOTO Takashi, DOI Junichi, NISHITANI Yoshihiro, YAMADA Tomiko, YOSHIYAMA Masahiro

    46   1 - 120   2003.5

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  • Optimizing filler content in an adhesive system containing pre-reacted glass-ionomer fillers

    K Ikemura, FR Tay, Y Kouro, T Endo, M Yoshiyama, K Miyai, DH Pashley

    DENTAL MATERIALS   19 ( 2 )   137 - 146   2003.3

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    Objectives. (1) To evaluate the optimal concentration of the calcium type pre-reacted glass-ionomer (PRG-Ca) fillers in experimental light-activated adhesives for bonding to tooth substrates and fluoride release; (2) to evaluate the polymerization reactivity of these experimental filled adhesives; and (3) to examine the ultrastructure of the resin-dentin interface bonded with the commercial version of this self-etching adhesive (Imperva Fluoro Bond, Shofu Inc., Kyoto, Japan).
    Materials and methods. PRG-Ca fillers were prepared from the acid-base reaction of calcium type fluoroaluminosilicate glass with poly(acrylic acid) in water. Different experimental light-cured adhesives were prepared, with 0-57 wt% PRG-Ca fillers and 3 wt% aerosil silica incorporated in a resin matrix. Twenty-four hours shear bond strengths to bovine enamel and dentin were assessed using the adhesive with/or without accelerated aging. The cumulative amount of fluoride released from the cured adhesives and differential scanning calorimetry (DSC) measurements were also conducted. 180-grit SiC paper polished human dentin disks were treated with Imperva Fluoro Bond that contains 17 wt% PRG-Ca fillers and prepared for TEM examination.
    Results. Increase in PRG-Ca filler content of experimental adhesives was highly correlated with the decrease in bond strengths to dentin (r = -0.96 to -0.99), the increase in cumulative fluoride release, (r = 0.97) and the decrease in polymerization energy (cal/g) of the adhesives (r = -0.99) (p &lt; 0.001). A PRG-Ca content of 17 wt% provided optimal bond strength to enamel and dentin after accelerated aging and fluoride release. TEM showed that salt-like matrices were present around the hydrogels and remnant glass cores of the PRG-Ca fillers. The commercial self-etching primer completely dissolved the smear layer and formed 2 mum thick hybrid layers in intact dentin.
    Significance. The use of silanized PRG-Ca fillers provides good adhesion and a source of fluoride release in a commercially available self-etching adhesive system. (C) 2003 Academy of Dental Materials. Published by Elsevier Science Ltd. All rights reserved.

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  • Effect of fluoride-releasing adhesive system on decalcified dentin

    T. Itota, Y. Torii, S. Nakabo, Y. Tashiro, N. Konishi, M. Nagamine, M. Yoshiyama

    Journal of Oral Rehabilitation   30 ( 2 )   178 - 183   2003.2

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    The aim of this study was to evaluate the effect of fluoride-releasing adhesive systems on human decalcified dentin in vitro. Two fluoride-releasing adhesive systems, Reactmer bond (RB, Shofu) and ABF (AF, Kuraray), an experimental system, and a commercial adhesive system without fluoride release, SE bond (SE, Kuraray), were used in this study. The amount of fluoride release from adhesive in deionized water was measured every week for 10 weeks. Class V cavities were prepared on extracted human pre-molars and decalcified dentin was promoted by using a bacterial caries induction system at the cavity floor. The cavities preserving decalcified dentin were restored with resin composite (AP-X, Kuraray) after treatment by each adhesive system. The specimens without treatment by adhesive system and restoration were used for control. The specimens with restoration were then incubated for 4 weeks at 37°C, 100% humidity. Microradiographs of the specimens showed that the radiopacities of the decalcified dentin layers in RB and AF groups with fluoride release were significantly higher than those in SE or control groups without fluoride release. This result suggested that the fluoride-releasing adhesive systems enhanced mineralization of decalcified dentin.

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  • Effect of fluoride-releasing adhesive system on decalcified dentin

    T. Itota, Y. Torii, S. Nakabo, Y. Tashiro, N. Konishi, M. Nagamine, M. Yoshiyama

    Journal of Oral Rehabilitation   30 ( 2 )   178 - 183   2003.2

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    The aim of this study was to evaluate the effect of fluoride-releasing adhesive systems on human decalcified dentin in vitro. Two fluoride-releasing adhesive systems, Reactmer bond (RB, Shofu) and ABF (AF, Kuraray), an experimental system, and a commercial adhesive system without fluoride release, SE bond (SE, Kuraray), were used in this study. The amount of fluoride release from adhesive in deionized water was measured every week for 10 weeks. Class V cavities were prepared on extracted human pre-molars and decalcified dentin was promoted by using a bacterial caries induction system at the cavity floor. The cavities preserving decalcified dentin were restored with resin composite (AP-X, Kuraray) after treatment by each adhesive system. The specimens without treatment by adhesive system and restoration were used for control. The specimens with restoration were then incubated for 4 weeks at 37°C, 100% humidity. Microradiographs of the specimens showed that the radiopacities of the decalcified dentin layers in RB and AF groups with fluoride release were significantly higher than those in SE or control groups without fluoride release. This result suggested that the fluoride-releasing adhesive systems enhanced mineralization of decalcified dentin.

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  • Effect of fluoride-releasing adhesive system on decalcified dentin

    T. Itota, Y. Torii, S. Nakabo, Y. Tashiro, N. Konishi, M. Nagamine, M. Yoshiyama

    Journal of Oral Rehabilitation   30 ( 2 )   178 - 183   2003.2

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    The aim of this study was to evaluate the effect of fluoride-releasing adhesive systems on human decalcified dentin in vitro. Two fluoride-releasing adhesive systems, Reactmer bond (RB, Shofu) and ABF (AF, Kuraray), an experimental system, and a commercial adhesive system without fluoride release, SE bond (SE, Kuraray), were used in this study. The amount of fluoride release from adhesive in deionized water was measured every week for 10 weeks. Class V cavities were prepared on extracted human pre-molars and decalcified dentin was promoted by using a bacterial caries induction system at the cavity floor. The cavities preserving decalcified dentin were restored with resin composite (AP-X, Kuraray) after treatment by each adhesive system. The specimens without treatment by adhesive system and restoration were used for control. The specimens with restoration were then incubated for 4 weeks at 37°C, 100% humidity. Microradiographs of the specimens showed that the radiopacities of the decalcified dentin layers in RB and AF groups with fluoride release were significantly higher than those in SE or control groups without fluoride release. This result suggested that the fluoride-releasing adhesive systems enhanced mineralization of decalcified dentin.

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  • Effect of fluoride-releasing adhesive system on decalcified dentin

    T Itota, Y Torii, S Nakabo, Y Tashiro, N Konishi, M Nagamine, M Yoshiyama

    JOURNAL OF ORAL REHABILITATION   30 ( 2 )   178 - 183   2003.2

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    The aim of this study was to evaluate the effect of fluoride-releasing adhesive systems on human decalcified dentin in vitro . Two fluoride-releasing adhesive systems, Reactmer bond (RB, Shofu) and ABF (AF, Kuraray), an experimental system, and a commercial adhesive system without fluoride release, SE bond (SE, Kuraray), were used in this study. The amount of fluoride release from adhesive in deionized water was measured every week for 10 weeks. Class V cavities were prepared on extracted human pre-molars and decalcified dentin was promoted by using a bacterial caries induction system at the cavity floor. The cavities preserving decalcified dentin were restored with resin composite (AP-X, Kuraray) after treatment by each adhesive system. The specimens without treatment by adhesive system and restoration were used for control. The specimens with restoration were then incubated for 4 weeks at 37 degreesC, 100% humidity. Microradiographs of the specimens showed that the radiopacities of the decalcified dentin layers in RB and AF groups with fluoride release were significantly higher than those in SE or control groups without fluoride release. This result suggested that the fluoride-releasing adhesive systems enhanced mineralization of decalcified dentin.

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  • Resin adhesion to carious dentin

    M Yoshiyama, FR Tay, Y Torii, Y Nishitani, J Doi, K Itou, B Ciucchi, DH Pashley

    AMERICAN JOURNAL OF DENTISTRY   16 ( 1 )   47 - 52   2003.2

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    Purpose: To investigate the microtensile bond strength (muTBS) of a self-etching priming adhesive system to normal, caries-affected and caries-infected dentin, and to observe the ultrastructure of the resin-dentin interface by transmission electron microscopy (TEM). Materials and Methods: Twelve extracted human molar teeth with deep occlusal caries were stained with caries detector solution and ground flat occlusally. The red-stained soft dentin was classified as caries-infected. The surrounding discolored dentin was classified as caries-affected dentin. The surrounding normal dentin served as a control. The entire flat surface was bonded with Clearfil Liner Bond 2V (CV) and covered with resin composite to form a composite crown 5 nun high. One day later the specimens were serially sectioned vertically into multiple slabs 0.8 mm thick. Under microscopic observation, the specimens were divided into normal or caries-infected or caries-affected dentin. These regions were isolated by cutting away the remaining dentin to form hour-glass shapes with the smallest surface area at the test site. After measuring the areas, the specimens were fixed to a microtensile tester and pulled under tension to failure. Additional slabs that were not used for bond strength tests were processed for TEM. Bond strength data were analyzed by Kruskal-Wallis one-way ANOVA and Student-Newman-Keuls multiple comparisons. Results: The muTBS of CV to normal, caries-affected and caries-infected dentin were 45 +/-10 MPa, 30 +/- 10 MPa, 10 +/- 5 MPa, respectively. TEM images showed that CV formed thin hybrid layers that were less than 1 mum thick in normal dentin, but that were between 6-8 mum thick in caries-affected dentin. Bacteria were only sparsely observed in the dentin tubules of bonded caries-affected dentin. However, in caries-infected dentin, an unusual interface was seen in which carious bacteria within disorganized non-banded collagen fibrils could be seen embedded by the adhesive. The hybrid layer in cariesinfected dentin was found to be 30-60 mum thick. (Am JDent 2003; 16: 47-52).

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  • 象牙質再生療法の開発--CTGF刺激によるヒト歯髄細胞におけるオステオネクチンの発現の解析--.

    清水洋利, 西谷佳浩, 山田登美子, 西田 崇, 滝川正春, 吉山昌宏

    日本再生歯科医学会誌   2003

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  • 岡山大学歯学部臨床実習直前学生に対するOSCEの試み--学生アンケート調査からの評価--.

    鳥井康弘, 吉田登志子, 荒川 光, 若狭 享, 宮脇正一, 新井英雄, 塚本剛一, 福永城司, 長塚 仁, 中村浩彰, 白井 肇, 糀谷 淳, 高木 愼, 岸本悦央, 嶋田昌彦, 山本敏男, 吉山昌宏, 鈴木一臣, 永井教之

    岡山歯学会雑誌   2003

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  • 新しいう蝕治療法を求めて--保存修復から象牙質再生への展開--.

    吉山昌宏, 西谷佳浩, 清水洋利, 土居潤一, 山田登美子, 堤 定美, 玄 丞烋, 前田伸子, 桃井保子, 秋元尚武, 今里 聡, 恵比須繁之, 斎藤隆史, 松田浩一

    日本歯科医学会誌   2003

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  • 臨床家のための歯髄の科学--注目の書籍「DENTAL PULP」に学ぶ--4. 歯髄-象牙質複合体の発生.

    吉山昌宏, 清水洋利, 高畑安光, 鳥井康弘, 伊東孝介, D’Souza R

    The Quintessence   22,4,139-145   2003

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  • 誌上収録SYMPOSIUM 公開シンポジウム「象牙質再生への新展開」より 第Ⅱ部 組織再生と再建のハーモナイゼーション シンポジウムの位置づけと意義.

    吉山昌宏

    The Quintessence   22,2,215   2003

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  • 誌上収録SYMPOSIUM 公開シンポジウム「象牙質再生への新展開」より 第Ⅰ部 象牙質/歯髄複合体の再生はどこまで可能か 成長因子(CTGF)を応用した象牙質再生療法開発の可能性を探る.

    清水洋利, 西谷佳浩, 山田登美子, 高橋和宏, 西田 崇, 滝川正春, 吉山昌宏

    The Quintessence   22,1,222-223   2003

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  • 誌上収録SYMPOSIUM 公開シンポジウム「象牙質再生への新展開」より 第Ⅰ部 象牙質/歯髄複合体の再生はどこまで可能か シンポジウムの位置づけと意義.

    吉山昌宏

    The Quintessence   22,1,215   2003

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  • 臨床家のための歯髄の科学--注目の書籍「DENTAL PULP」に学ぶ--5. 歯髄-象牙質複合体.

    高畑安光, 仲保 聡, 吉山昌宏, Pashley D

    The Quintessence   22,4,146-155   2003

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  • 根面う蝕への治療指針 ミニマム・インターベンションの視点から 各論4 根面う蝕治療における接着修復の信頼性.

    吉山昌宏, 土居潤一, 西谷佳浩

    The Quintessence   22,10,58-63   2003

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  • デンタルCAD/CAM GN-Iを応用した審美歯科修復.

    西谷佳浩, 山田登美子, 吉山昌宏

    デンタルダイヤモンド   28,7,144-146   2003

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  • FROM INTERNATIONAL JOURNALS:論文で知る臨床の潮流 各種フロアブルレジンのフローと皮膜厚さの検討.

    土居潤一, 仲保 聡, 吉山昌宏

    The Quintessence   22,4,200-201   2003

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  • Effect of fluoride application on tensile bond strength of self-etching adhesive systems to demineralized dentin

    T Itota, Y Torii, S Nakabo, M Yoshiyama

    JOURNAL OF PROSTHETIC DENTISTRY   88 ( 5 )   503 - 510   2002.11

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    Language:English   Publisher:MOSBY, INC  

    Statement of problem. It has been reported that the bond strength of composite to demineralized dentin is lower than that to sound dentin. This can be a problem in the success of so-called sealed restorations.
    Purpose. The aim of this study was to evaluate the effect of fluoride application on the tensile bond strength of self-etching adhesive systems to demineralized dentin.
    Material and methods. One hundred twenty extracted bovine incisors were ground flat with 600-grit silicone carbide paper. Ninety teeth were then immersed in acetate buffer (pH 4.0) to form demineralized dentin. These teeth were randomly divided into 3 groups of 30 each: surfaces treated with fluoride solution (Group NF), surfaces treated with fluoride solution followed by a water rinse (Group RF), and control surfaces with no pretreatment (Group C). The remaining 30 teeth comprised a group with normal dentin surfaces (Group S). Each group was further divided into 3 subgroups of 10 each to test the bond strength test of Clearfil SE Bond, unifil Bond, and Mac-Bond II. Tensile bond strengths (in MPa) were measured with a universal testing machine at a crosshead speed of 0.5 mm/min. Mean bond strengths were analyzed by 2-way analysis of variance and Fisher's PLSD (P = .05). SEM observations of the surfaces before and after priming and at resin-dentin interfaces in each group were performed. Elemental analysis of the dentin surfaces before priming was also carried out.
    Results. The bond strengths of the adhesives to demineralized dentin in Groups NF, RF, and C were significantly lower than that of the normal dentin in Group S (P .05). The mean bond strengths of the 3 adhesives in Group NF were higher than those in Groups RF and C, but a significant difference was observed only when Clearfil SE Bond was used (P &lt; .05). In SEM images the open dentinal tubules on the surface and the resin tag formation at the resin-dentin interface were apparent in Group NF but were not observed in Groups RF and C. On elemental analysis, considerable amounts of fluoride and calcium were detected in the surfaces of Group NF.
    Conclusion. Within the limitations of this study, the surface treatment with fluoride solution supported the resin tag formation at the resin-dentin interface and slightly improved the bond strength of the self-etching adhesive systems tested to demineralized dentin. This result indicated that the fluoride treatment to demineralized dentin might contribute to the success of the sealed restoration.

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  • Effect of etching time on shrinkage and expansion of dentin etched with phosphoric acid

    ITOU K., TORII Y., YOSHIDA Y., SUZUKI K., YOSHIYAMA M., PASHLEY D.H.

    21   21 - 21   2002.8

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  • Bonding of self-etch and total-etch adhesives to carious dentin

    M Yoshiyama, FR Tay, J Doi, Y Nishitani, T Yamada, K Itou, RM Carvalho, M Nakajima, DH Pashley

    JOURNAL OF DENTAL RESEARCH   81 ( 8 )   556 - 560   2002.8

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    Carious dentin is partially demineralized and contains mineral crystals in the tubules. This may permit the deeper etching of intertubular dentin but prevent resin tag formation during bonding. We hypothesize that resin adhesives will produce lower bond strengths to caries-infected and caries-affected dentin compared with normal dentin. We tested this by measuring the microtensile bond strength of a total-etch adhesive and an experimental self-etching adhesive (ABF) to caries-infected, caries-affected, and sound dentin and by correlating those results with ultrastructural observations. The bond strengths of both adhesives to sound dentin were significantly (p &lt; 0.05) higher than those to caries-affected dentin, which, in turn were significantly (p &lt; 0.05) higher than those to caries-infected dentin. For both adhesives, hybrid layers in caries-affected dentin were thicker but more porous than those in sound dentin. The lower bond strengths may be due to the lower tensile strength of caries-affected dentin. Clinically, this may not be a problem, since such lesions are normally surrounded by normal dentin or enamel.

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  • Effects of fluoride release from bis-GMA/TEGDMA resin regulated by gamma-methacryloxypropyltrimethoxysilane on demineralization of bovine enamel

    S Nakabo, Y Torii, T Itota, K Ishikawa, K Miyazaki, K Suzuki, M Yoshiyama

    BIOMATERIALS   23 ( 16 )   3503 - 3508   2002.8

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    We previously demonstrated that fluoride release from resins could be regulated by the polysiloxane coating of the fluoride additives. The present study investigated the effects of regulated fluoride release from resin oil enamel demineralization in vitro. Bovine enamel cavities were restored with bis-GMA/TEGDMA resins containing 50wt% NaF powders treated with or without gamma-methacryloxypropyltrimethoxysilane. Specimens were immersed in distilled water that was changed daily to measure the amount of fluoride released over 40 days, and thereafter Subjected to pH-cycling. Microradiographic observations were performed to determine total mineral loss (DeltaZ) and lesion depth (Ld) on the enamel. In addition, fluorine distribution was analyzed using EPMA. The resin containing untreated NaF exhibited high-rate and short-term fluoride release, whereas the resin containing treated NaF released low concentrations of fluoride over a longer period. The former showed high fluorine Uptake in the adjacent enamel. In contrast, the latter showed high fluorine uptake not only in the adjacent enamel, but also in a wider area of enamel surface. The latter also showed lower AZ and Ld values in the surrounding enamel, indicating a high inhibitory effect on caries formation. Therefore. it is Suggested that regulated fluoride release front the resin based on polysiloxane coating is effective in preventing caries formation. (C) 2002 Elsevier Science Ltd. All rights reserved.

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  • Two modes of nanoleakage expression in single-step adhesives

    FR Tay, DH Pashley, M Yoshiyama

    JOURNAL OF DENTAL RESEARCH   81 ( 7 )   472 - 476   2002.7

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    Self-etch adhesives that etch, prime, and bond simultaneously should not exhibit incomplete resin infiltration within hybrid layers. We hypothesized that nanoleakage patterns in these systems are artifacts caused by mineral dissolution in mildly acidic silver nitrate. Resin-dentin interfaces bonded with four single-step. self-etch adhesives were examined for nanoleakage by conventional (pH 4.2) and basic ammoniacal (pH 9.5) silver nitrate and prepared for transmission electron microscopy. All adhesives exhibited a reticular mode of nanoleakage within hybrid layers when conventional silver nitrate was used, With ammoniacal silver nitrate, an additional spotted pattern of nanoleakage was observed within adhesive and hybrid layers. The reticular mode of nanoleakage in self-etch adhesives probably represents sites of incomplete water removal that leads to regional suboptimal polymerization. The spotted pattern identified with the use of ammoniacal silver nitrate probably represents potentially permeable regions in the adhesive and hybrid layers that result from the interaction of the basic diamine silver ions with acidic/hydrophilic resin components.

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  • Regulation of fluoride ion release from Na2SiF6 contained in resin based on hydrophobic siloxane layer coating

    S Nakabo, Y Torii, T Itota, M Yoshiyama, K Ishikawa, K Suzuki

    JOURNAL OF ORAL REHABILITATION   29 ( 7 )   675 - 681   2002.7

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    Regulation of fluoride release from restorative resin or sealant is beneficial to patients as it will prevent the occurrence of the secondary caries. In this study, we evaluated whether or not the formation of a hydrophobic polysiloxane layer on the surface of the fluoride compound could contribute to the regulation of fluoride release from resin. First, sodium hexafluorosilicate (Na2SiF6) powder was treated with gamma-methacryloxypropyltrimethoxysilane (gamma-MPTS) and analysed with scanning electronmicroscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR) and electron spectroscopy for chemical analysis (ESCA). Analysis revealed that a hydrophobic polysiloxane layer was formed on the surface of Na2SiF6 powder. Heat treatment commonly used during gamma-MPTS treatment was not necessary for the polysiloxane layer formation on the surface of Na2SiF6 powder. Then Na-2 SiF6 powder treated with gamma-MPTS was loaded in bis-GMA/TEGDMA resin, immersed in distilled water and fluoride release was measured using a fluoride electrode. We found that the rate of fluoride release was significantly lower from the resin containing Na2SiF6 powder treated with c-MPTS. We concluded, therefore, that c-MPTS treatment and the resulting hydrophobic polysiloxane layer formation are very effective for the regulation of fluoride release from resin.

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  • Inhibition of artificial secondary caries by fluoride-releasing adhesives on root dentin

    T Itota, S Nakabo, Y Iwai, N Konishi, M Nagamine, Y Torii

    JOURNAL OF ORAL REHABILITATION   29 ( 6 )   523 - 527   2002.6

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    Fluoride-releasing materials can be expected to inhibit the secondary caries. The aim of this study was to evaluate the effect of fluoride-releasing adhesives on inhibition of secondary caries in outer and wall lesions. Two commercial fluoride-releasing adhesives, Reactmer bond (RB) and One-up bond F (OB), and a commercial adhesive without fluoride release, Mac-bond II (MB), were used prior to placement of restorative materials without fluoride release, Lite-fil II A (LF) and Estelite (EL), and a fluoride-releasing restorative material, Reactmer paste (RP). Class V cavities prepared on extracted human premolars were restored with various combinations of the materials: MB/EL, OB/EL, RB/LF and RB/RP. The restored teeth were incubated in bacterial medium containing sucrose with Streptoccus mutans for 14 days. Microradiographs of specimens showed no wall lesions in all groups and an acid-resistant layer adjacent to the restoration in the caries-like lesion. OB/EL, RB/LF and RB/RP groups showed thicker layers than the MB/EL group. The RB/RP group formed the shallowest outer lesion among all groups. These results indicate that fluoride-releasing adhesives are effective in the prevention of wall lesions but exhibit little outer lesion inhibition. Therefore, combined restoration using a fluoride-releasing adhesive and fluoride-releasing restorative material should be selected to inhibit secondary caries.

    DOI: 10.1046/j.1365-2842.2002.00858.x

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  • Influence of dentin conditioning using amino acid monomer on morphological structure of collagen and adhesion

    NISHITANI Y., TORII Y., YAMADA T., SHIMIZU H., ITOTA T., SUZUKI K., YAMAMOTO T., YOSHIYAMA M.

    19 ( 4 )   375 - 375   2002.3

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  • Resin adhesion to caries-affected and caries-infected dentin.

    Y Nishitani, T Yamada, T Itota, H Shimizu, M Yoshiyama, DH Pashley

    JOURNAL OF DENTAL RESEARCH   81   A70 - A70   2002.3

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  • ワンステップ型接着システムの象牙質接着性に及ぼす前処理の効果

    暈 理恵, 小山史子, 岩田修一, 伊東孝介, 佐藤公平, 鳥井康弘, 吉山昌宏

    日本歯科保存学雑誌   2002

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  • ワンステップ型接着システムの象牙質接着性に及ぼす前処理の効果.

    暈 理恵, 小山史子, 岩田修一, 伊東孝介, 佐藤公平, 鳥井康弘, 吉山昌宏

    日本歯科保存学雑誌   2002

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  • Development of Dentin Regeneration Therapy : Expression of Type I Collagen and Alkaline Phosphatase Induced by CTGF in Human Cultured Dental Pulp.

    Shimizu H, Nishitani Y, Yamada T, Nishida T, Takigawa M, Yoshiyama M

    J Hard Tissue Biology   2002

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  • 齲蝕病巣下のDentin/Pulp Complexにおける病理組織学的変化について.

    糸田俊之, 田代陽子, 鳴神智子, 黒崎昭夫, 高畑安光, 仲保 聡, 西谷佳浩, 高務朋将, 清水洋利, 伊澤俊次, 小西法文, 鳥井康弘, 吉山昌宏

    岡山歯学会雑誌   2002

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  • Effect of adhesives on the inhibition of secondary caries around compomer restorations

    T Itota, S Nakabo, Y Iwai, N Konishi, M Nagamine, Y Torii, M Yoshiyama

    OPERATIVE DENTISTRY   26 ( 5 )   445 - 450   2001.9

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    This study evaluated the effect of adhesives on the inhibition of secondary caries around compomer restorations in vitro. Two adhesive systems with a Bis-GMA resin, Scotch bond Multipurpose (MP) and Single Bond (SB), and one adhesive system with no Bis-GMA resin, F2000 compomer primer/adhesive (PA), were used prior to placement of the compomer (F2000), and nonfluoride releasing resin composite (Z100) was used as a control. Class V cavities prepared on extracted human premolars were restored with various combinations of materials: F2000/MP, F2000/SB, F2000/PA, Z100/MP, Z100/SB and Z100/PA. The restored teeth were incubated in bacterial medium containing sucrose with Streptococcus mutans for two weeks after storage for 14 days. On microradiographs, the radioopaque layers adjacent to the F2000 restorations were thick and clear, while the layers in the Z100 restorations were unclear. In the F2000 restorations, the mean thickness of the radio-opaque layers in the PA group was significantly greater than that of the MP and SB groups. In fluoride-releasing measurement, F2000 coated with PA showed a significantly higher amount of fluoride release than MP and SB, and no significant difference in the amount of fluoride release from uncoated F2000.
    These results indicated that applying an adhesive without Bis-GMA resin to compomer restoration has no suppressive effect on the fluoride release from compomer and might be beneficial for inhibiting secondary caries in vitro.

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  • Adhesion of Flowable Resins to Root Carious Dentin

    CHIKAMI Kana, DOI Junichi, YAMADA Tomiko, NISHITANI Yoshihiro, ITOU Kousuke, TORII Yasuhiro, YOSHIYAMA Masahiro

    19 ( 2 )   110 - 116   2001.8

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  • Effects of Polysiloxane Coating of NaF on the Release Profile of Fluoride Ion from Bis-GMA/TEGDMA Resin Containing NaF

    Satoshi Nakabo, Yasuhiro Torii, Toshiyuki Itota, Masahiro Yoshiyama, Kunio Ishikawa, Kazuomi Suzuki

    Dental Materials Journal   20 ( 1 )   53 - 62   2001

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    The aim of this study was to regulate fluoride release from restorative resin containing NaF using N-(β-aminoethyl)-γ-aminopropylmethyldimethoxysilane (AMMS) and evaluate factors that regulate fluoride release from the resin. ESCA analysis, FT-IR measurements along with SEM observations demonstrated that a polysiloxane layer was formed on the surface of NaF treated with AMMS. Bis-GMA/TEGDMA resin containing NaF powder treated with AMMS released lower concentrations of fluoride for longer periods when compared with that containing untreated NaF. However, AMMS treatment of NaF was less effective for the regulation of fluoride released from the resin than γ-methacryloxypropyltrimethoxysilane (γ-MPTS) treatment, despite its higher hydrophobic polysiloxane layer formation. These findings may have been caused by the higher density of polysiloxane prepared with γ-MPTS than that prepared with AMMS. The present findings suggested, therefore, that alkoxysilane should be chosen based not only on hydrophobicity but also the density of polysiloxane to effectively regulate fluoride release from the restorative resin containing NaF.

    DOI: 10.4012/dmj.20.53

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  • 楔状欠損と歯根露出による知覚過敏の発症メカニズムと予防

    吉山昌宏, 糸田俊之, 西谷佳浩

    歯界展望   98(6), 1195-1198   2001

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  • 脱灰象牙質コラーゲンのin vitro石灰化に対する2-hydroxyethyl methacrylate(HEMA)の影響

    斉藤隆史, 仲保 聡, 土居潤一, 西谷佳浩, 伊藤修一, 松田浩一, 吉山昌宏

    日本歯科保存学雑誌   2001

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  • 窩洞形成時疼痛の中枢抑制機構の解明

    伊澤俊次, 土居潤一, 山田登美子, 仲保 聡, 西谷佳浩, 高務朋将, 伊東孝介, 糸田俊之, 小西法文, 永峰道博, 鳥井康弘, 吉山昌宏

    日本歯科保存学雑誌   2001

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  • フッ素徐放性接着システムによる脱灰象牙質の再石灰化

    糸田俊之, 岩井陽一郎, 岡本美々子, 田代陽子, 仲保 聡, 西谷佳浩, 永峰道博, 鳥井康弘, 吉山昌宏

    日本歯科保存学雑誌   2001

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  • MIを生かす接着材料の新展開 接着の最新動向から

    吉山昌宏, 鳥井康弘, 糸田俊之, 西谷佳浩

    the Quintessence Year Book 2001   別冊,22-28   2001

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  • 新しいう蝕治療を求めて -シールド・レストレーションの可能性-

    吉山昌宏, 西谷佳浩, 土居潤一, 山田登美子, 鳥井康弘

    The Journal of dental Engineering   136, 27-30   2001

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  • ハイブリッド型硬質レジン「エステニア」インレーの臨床経過

    鳥井康弘, 吉山昌宏

    The Journal of dental Engineering   136, 7-10   2001

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  • 抗菌モノマーMDPB配合試作接着システムの齲蝕象牙質中の嫌気性菌に対する抗菌効果について

    高務朋将, 石尾富貴子, 黒崎昭夫, 高畑安光, 小西法文, 佐藤公平, 鳥井康弘, 吉山昌宏

    日本歯科保存学雑誌   2001

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  • In vitro resin bonding to artificial carious dentin

    A. Urayama, S. Nakabo, T. Kimochi, Y. Nishitani, Y. Doi, T. Matsuo, M. Yoshiyama

    Journal of Hard Tissue Biology   2001

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  • 歯科保存領域の感染症に対する抗菌薬アジスロマイシン(ジスロマックィ)の臨床効果

    鳥井康弘, 永峰道博, 吉山昌宏

    デンタルダイヤモンド   26 (368), 173-175   2001

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  • Comparison of conventional vs self-etching adhesive bonds to caries-affected dentin

    M Yoshiyama, A Urayama, T Kimochi, T Matsuo, DH Pashley

    OPERATIVE DENTISTRY   25 ( 3 )   163 - 169   2000.5

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    The mechanism of resin adhesion to caries-affected dentin is still unclear, This study evaluated the interfacial morphology of two bonding systems to caries-affected dentin, coupled with the measurement of microtensile bond strengths (mu TBS). Carious human molars were prepared as previously described in Nakajima and others (1995) and were bonded with Single Bond (SB) or FluoroBond (FB) according to the manufacturer's instructions, followed by creation of AP-X composite buildups, After one day of storage in 37 degrees C water, the teeth were serially sectioned vertically into 0.8 mm slabs, trimmed to yield a 1 mm(2) test area, and tested to failure in a Bencor device used in an Instron machine operated at 1 mm/min. Resin-dentin interfaces were observed with SEM before or after acid/base challenge, Bonding to normal dentin with the two bonding systems (SB and FB) showed tensile bond strengths significantly higher than those to caries-affected dentin, The moist bonding technique significantly increased bond strength of SE to normal and caries-affected dentin, SEM examination revealed that typical hybrid layer and resin tags could not be formed to caries-affected dentin, The results suggested that resin penetration may be prevented by occlusion of dentinal tubules by mineral deposits that may also impart acid-resistance to the intertubular matrix of caries-affected dentin.

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  • Morphological changes of enamel surfaces adjacent to restorations by demineralization

    Nagamine M, Henmi C, Itota T, Torii Y, Marshall GW, Staninec M, Yoshiyama M

    The Electronic Journal for Dentistry   2000

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  • Long-term mechanical properties of EDTA-demineralized dentin matrix

    Ricardo M. Carvalho, Franklin Tay, Hidehiko Sano, Masahiro Yoshiyama, David H. Pashley

    Journal of Adhesive Dentistry   2 ( 3 )   193 - 199   2000

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    Purpose: To determine the long-term ultimate tensile strength (UTS) and modulus of elasticity (E) of EDTA-demineralized human dentin after storage in PBS (phosphate buffered saline) for up to 48 months. Materials and Methods: Dentin beams measuring 0.7 × 0.7 × 8.0 mm were prepared from the crowns of extracted human third molars. The ends of the beams were covered with resin composite and demineralized for 6 days in 0.5 mol/L EDTA (pH = 7.0). Demineralized control specimens were subjected to tensile testing at 0.5 mm/min after 24 hours of immersion in PBS solution. Experimental specimens were stored in PBS at room temperature (25°C) and tested after 18 and 48 months. The maximum load at failure and the load/displacement curves were used to calculate the UTS as a function of the cross-sectional area and E, respectively. The results were analyzed by ANOVA and Student Neuman Keuis tests. TEM micrographs were obtained from the control specimens and from those that were stored and tested after 48 months. Results: No significant changes in either UTS or E were observed in the specimens after long-term storage. The 48-month values were not statistically significantly different from the values obtained at 24 hours (p &gt
    0.05). TEM images revealed a normal, intact structure of the collagen fibrils with no signs of degradation or denaturation. Conclusion: Long-term storage of EDTA-demineralized human dentin in PBS solution did not cause any significant reduction of its mechanical properties. The structure of the collagen fibrils as observed by TEM appeared normal and did not seem affected by long-term storage.

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  • Adhesion in vitro of Oral Streptococci to Porcelain, Composite Resin Cement and Human Enamel

    Tomomasa Takatsuka, Norifumi Konishi, Satoshi Nakabo, Takeshi Hashimoto, Yasuhiro Torii, Masahiro Yoshiyama

    Dental Materials Journal   19 ( 4 )   363 - 372   2000

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    We investigated the initial adhesion in vitro of oral streptococci to porcelain inlays. Four strains of streptococci, Streptococcus mitis NCTC12261, Streptococcus oralis ATCC9811, Streptococcus sanguis ATCC10556 and Streptococcus sobrinus OMZ176, were used in this study. The disc specimens were made of porcelain, composite resin cement and human enamel. These specimens, with or without a saliva-coat, were immersed in a suspension of each streptococci strain at 37°C for 1 hr, and the numbers of cells adhering to specimens were counted after staining. The saliva-coat significantly decreased the numbers of adhering cells in all strains tested (t-test, p&lt
    0.05). The adhesion to the porcelain and resin cements could be explained by a thermodynamic approach, although the adhesion to enamel could not be explained. These results indicated the possibility that the mechanism is different in initial adhered strains of streptococci between enamel and dental restorative materials.

    DOI: 10.4012/dmj.19.363

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  • Long-term mechanical properties of EDTA-demineralized dentin matrix

    Ricardo M. Carvalho, Franklin Tay, Hidehiko Sano, Masahiro Yoshiyama, David H. Pashley

    Journal of Adhesive Dentistry   2 ( 3 )   193 - 199   2000

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    Purpose: To determine the long-term ultimate tensile strength (UTS) and modulus of elasticity (E) of EDTA-demineralized human dentin after storage in PBS (phosphate buffered saline) for up to 48 months. Materials and Methods: Dentin beams measuring 0.7 × 0.7 × 8.0 mm were prepared from the crowns of extracted human third molars. The ends of the beams were covered with resin composite and demineralized for 6 days in 0.5 mol/L EDTA (pH = 7.0). Demineralized control specimens were subjected to tensile testing at 0.5 mm/min after 24 hours of immersion in PBS solution. Experimental specimens were stored in PBS at room temperature (25°C) and tested after 18 and 48 months. The maximum load at failure and the load/displacement curves were used to calculate the UTS as a function of the cross-sectional area and E, respectively. The results were analyzed by ANOVA and Student Neuman Keuis tests. TEM micrographs were obtained from the control specimens and from those that were stored and tested after 48 months. Results: No significant changes in either UTS or E were observed in the specimens after long-term storage. The 48-month values were not statistically significantly different from the values obtained at 24 hours (p &gt
    0.05). TEM images revealed a normal, intact structure of the collagen fibrils with no signs of degradation or denaturation. Conclusion: Long-term storage of EDTA-demineralized human dentin in PBS solution did not cause any significant reduction of its mechanical properties. The structure of the collagen fibrils as observed by TEM appeared normal and did not seem affected by long-term storage.

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  • Adhesion in vitro of Oral Streptococci to Porcelain, Composite Resin Cement and Human Enamel

    Tomomasa Takatsuka, Norifumi Konishi, Satoshi Nakabo, Takeshi Hashimoto, Yasuhiro Torii, Masahiro Yoshiyama

    Dental Materials Journal   19 ( 4 )   363 - 372   2000

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    We investigated the initial adhesion in vitro of oral streptococci to porcelain inlays. Four strains of streptococci, Streptococcus mitis NCTC12261, Streptococcus oralis ATCC9811, Streptococcus sanguis ATCC10556 and Streptococcus sobrinus OMZ176, were used in this study. The disc specimens were made of porcelain, composite resin cement and human enamel. These specimens, with or without a saliva-coat, were immersed in a suspension of each streptococci strain at 37°C for 1 hr, and the numbers of cells adhering to specimens were counted after staining. The saliva-coat significantly decreased the numbers of adhering cells in all strains tested (t-test, p&lt
    0.05). The adhesion to the porcelain and resin cements could be explained by a thermodynamic approach, although the adhesion to enamel could not be explained. These results indicated the possibility that the mechanism is different in initial adhered strains of streptococci between enamel and dental restorative materials.

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  • 次世代の充填材料評価法:信頼性とトラッキング

    吉山昌宏

    バウンダリー   16 (2),6-11   2000

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  • Long-term mechanical properties of EDTA-demineralized dentin matrix

    Ricardo M. Carvalho, Franklin Tay, Hidehiko Sano, Masahiro Yoshiyama, David H. Pashley

    Journal of Adhesive Dentistry   2 ( 3 )   193 - 199   2000

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    Purpose: To determine the long-term ultimate tensile strength (UTS) and modulus of elasticity (E) of EDTA-demineralized human dentin after storage in PBS (phosphate buffered saline) for up to 48 months. Materials and Methods: Dentin beams measuring 0.7 × 0.7 × 8.0 mm were prepared from the crowns of extracted human third molars. The ends of the beams were covered with resin composite and demineralized for 6 days in 0.5 mol/L EDTA (pH = 7.0). Demineralized control specimens were subjected to tensile testing at 0.5 mm/min after 24 hours of immersion in PBS solution. Experimental specimens were stored in PBS at room temperature (25°C) and tested after 18 and 48 months. The maximum load at failure and the load/displacement curves were used to calculate the UTS as a function of the cross-sectional area and E, respectively. The results were analyzed by ANOVA and Student Neuman Keuis tests. TEM micrographs were obtained from the control specimens and from those that were stored and tested after 48 months. Results: No significant changes in either UTS or E were observed in the specimens after long-term storage. The 48-month values were not statistically significantly different from the values obtained at 24 hours (p &gt
    0.05). TEM images revealed a normal, intact structure of the collagen fibrils with no signs of degradation or denaturation. Conclusion: Long-term storage of EDTA-demineralized human dentin in PBS solution did not cause any significant reduction of its mechanical properties. The structure of the collagen fibrils as observed by TEM appeared normal and did not seem affected by long-term storage.

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  • 根面う蝕へのシールド・レストレーションの応用:根面う蝕象牙質へのレジン接着性

    吉山昌宏, 伊東孝介, 西谷佳浩, 仲保 聡, 土居潤一, 山田登美子, 鳥井康弘, 松尾敬志, 浦山明久, 木持 健

    接着歯学   2000

  • 齲蝕・接着・修復の新たな展開:シールドレストレーションをめぐって シールドレストレーションの可能性

    吉山昌宏

    デンタルダイヤモンド   25 (5), 34-38   2000

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  • 接着性レジンを知覚過敏の臨床に生かす

    吉山昌宏, 木持健, 浦山明久, 松尾敬志

    クインテッセンス   19 (5), 35-41   2000

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  • Resin adhesion to caries-infected dentin.

    M Yoshiyama, T Kimochi, A Urayama, T Matsuo, DH Pashley

    JOURNAL OF DENTAL RESEARCH   79   510 - 510   2000

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  • う蝕象牙質へのレジン接着性:セルフエッチングボンディングシステムの効果

    吉山昌宏, 松尾敬志, 浦山明久, 木持健

    日本接着歯学会雑誌   1999

  • Adhesion of a New Commercial Self-etching/Self-priming Bonding Resin to Human Caries-infected Dentin

    Takeshi Kimochi, Masahiro Yoshiyama, Akihisa Urayama, Takashi Matsuo

    Dental Materials Journal   18 ( 4 )   437 - 443   1999

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    We have examined the adhesive properties of a new commercial self-etching/self-priming bonding resin (Unifil Bond, UB) to normal and caries-infected dentin of human extracted molars using scanning electron microscopy (SEM) and a micto-tensile bonding strength (MTBS) test. In this study, 7 human extracted molars with moderate occlusal caries were used, and flat surfaces including occlusal dentin caries were prepared from the teeth. After the application of UB to the surfaces, a composite resin was built up, and subjected to the measurement of MTBS and SEM observation of the interfacial morphology between UB and dentin. The MTBS of UB to normal dentin was 33.4 MPa, but that to caries-infected dentin was 11.0 MPa. There was a significant difference between the MTBS to normal and carious dentin. SEM observation revealed that the typical hybrid layer was not formed in caries-infected dentin. These results suggested that resin infiltration into caries-infected dentin was not sufficient to allow perfect sealing of the restoration.

    DOI: 10.4012/dmj.18.437

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  • The microtensile bond test: A review

    David H. Pashley, Ricardo M. Carvalho, Hidehiko Sano, Masatoshi Nakajima, Masahiro Yoshiyama, Yasuo Shono, Carlos A. Fernandes, Franklin Tay

    Journal of Adhesive Dentistry   1 ( 4 )   299 - 309   1999

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    Purpose: The purpose of this review is to describe all of the various modifications of the microtensile bond test in one paper, so that investigators can select the modification that best suits their needs. Methods: The essence of the microtensile test is the division of resin-bonded teeth into slabs between 0.5 and 1.0 mm thick that are then trimmed in such a manner that tensile force will be concentrated on the bonded interface during testing. Among the many advantages of the technique are that each tooth produces multiple specimens. Further, there is no need for a matrix to limit the bonded surface area, since the area is determined by the dimensions of the trimmed specimens. Results: The various modifications of the microtensile test have been used to measure differences in regional bond strength across occlusal dentin, down the external surface of teeth from crown through roots, down the internal surface of root canals from cervical to apical thirds, as well as to compare normal vs caries-affected occlusal dentin and normal vs sclerotic cervical dentin. The technique is ideal for evaluating the long-term durability of resin-hard-tissue bonds. Conclusion: The microtensile test methods offer versatility that cannot be achieved by conventional methods. It is more labor-intensive than conventional testing, but holds great potential for providing insight into the strength of adhesion of restorative materials to clinically relevant sites and substrates.

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  • 人工象牙質ウ蝕へのレジン浸透性

    浦山明久, 吉山昌宏, 木持健, 松岡希実, 尾崎和美, 松尾敬志

    日本歯科保存学雑誌   1999

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  • SEM evaluation and bond strength to caries-affected dentin.

    M Yoshiyama, T Matsuo, DH Pashley

    JOURNAL OF DENTAL RESEARCH   77 ( 5 )   1304 - 1304   1998.5

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  • Interfacial morphology and bond strength to caries-affected dentin.

    M Yoshiyama, T Matsuo, DH Pashley

    JOURNAL OF DENTAL RESEARCH   77   226 - 226   1998

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  • Durability of bond strengths to dog dentin in vivo.

    M Yoshiyama, T Matsuo, DH Pashley

    JOURNAL OF DENTAL RESEARCH   77   657 - 657   1998

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  • In vitro study on the dimensional changes of human dentine after demineralization

    R. M. Carvalho, M. Yoshiyama, E. L. Pashley, D. H. Pashley

    Archives of Oral Biology   41 ( 4 )   369 - 377   1996

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    Dentine rods measuring approximately 0.7 × 0.7 × 5.0 mm were prepared from dentine of extracted human third molars stored in saline containing 0.5% sodium azide at 4°C until used. Forty specimens were demineralized in 10% citric acid plus 3% ferric chloride (w/w) solution for 8h, then assigned to four groups (A, B, C and D) of 10 specimens each. Groups A and B were used to investigate volumetric changes after air-drying and further immersion in either water, an aqueous solution of 50% 2-hydroxymethylmethacrylate (HEMA) or 100% HEMA, followed by air-drying. Groups C and D were used to investigate the ability of 100% HEMA or 100% ethylene glycol to prevent shrinkage of demineralized dentine during exposure to air. Demineralization caused a small, non-significant (1.9%) reduction in dentine volume. Air-drying further reduced the volume by 65.6%. When demineralized, shrunken specimens were immersed in water for 24 h, they recovered their original demineralized volume. Immersion in 100% HEMA did not re-expand demineralized shrunken dentine. Specimens immersed in 50% HEMA yielded a 50% volume shrinkage when exposed to air for 24 h. Both 100% HEMA and 100% ethylene glycol were effective in preventing shrinkage of demineralized dentine. The technique used provided useful information about maximal dimensional changes that may occur at a microscopic level during adhesive dental restorative procedures. Copyright © 1996 Elsevier Science Ltd.

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  • Regional bond strengths of resins to human root dentine

    M. Yoshiyama, R. M. Carvalho, H. Sano, J. A. Horner, P. D. Brewer, David H. Pashley

    Journal of Dentistry   24 ( 6 )   435 - 442   1996

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    Objectives: The demand for restoration of root dentine defects such as cervical erosion and root caries has significantly increased recently, but there is limited information on the performance of the adhesive resins to radicular dentine. The purpose of this study was to measure the regional tensile bond strength (TBS) of composite bonded to human root and coronal dentine, and to observe the interface between resin and root dentine by SEM. Methods: Human extracted cuspid teeth were used to measure TBS with a new microtensile bond test. Enamel and cementum were removed from the labial tooth surfaces to form a long cavity preparation into dentine from the mid-crown to the apex of the root within the same tooth. All Bond 2 (all etch technique) or Imperva Bond (no etch) was bonded to dentine surfaces and covered with Protect Liner resin composite. The resin-bonded teeth were serially sliced into 16 sections at right angles to the long axis of the tooth, and the bonded surfaces were trimmed to give a bonded surface area of 1 mm2 for TBS testing. Results: All Bond 2 bond strengths to coronal and apical dentine showed high values (23.5 MPa) but the bond strength was significantly lower on cervical root dentine. Imperva Bond produced a relatively high tensile bond strength to all regional areas. SEM showed that the thickness of the resin-infiltrated layer formed by All Bond 2 in root dentine was less than coronal areas. Resin infiltration with Imperva Bond was always less than 0.5 μm. The results suggest that high TBS values can be obtained with minimal resin infiltration in root dentine. Copyright © 1996 Elsevier Science Ltd.

    DOI: 10.1016/0300-5712(95)00102-6

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  • Regional bond strengths of resins to human root dentine

    M. Yoshiyama, R. M. Carvalho, H. Sano, J. A. Horner, P. D. Brewer, David H. Pashley

    Journal of Dentistry   24 ( 6 )   435 - 442   1996

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    Language:English   Publisher:Elsevier BV  

    Objectives: The demand for restoration of root dentine defects such as cervical erosion and root caries has significantly increased recently, but there is limited information on the performance of the adhesive resins to radicular dentine. The purpose of this study was to measure the regional tensile bond strength (TBS) of composite bonded to human root and coronal dentine, and to observe the interface between resin and root dentine by SEM. Methods: Human extracted cuspid teeth were used to measure TBS with a new microtensile bond test. Enamel and cementum were removed from the labial tooth surfaces to form a long cavity preparation into dentine from the mid-crown to the apex of the root within the same tooth. All Bond 2 (all etch technique) or Imperva Bond (no etch) was bonded to dentine surfaces and covered with Protect Liner resin composite. The resin-bonded teeth were serially sliced into 16 sections at right angles to the long axis of the tooth, and the bonded surfaces were trimmed to give a bonded surface area of 1 mm2 for TBS testing. Results: All Bond 2 bond strengths to coronal and apical dentine showed high values (23.5 MPa) but the bond strength was significantly lower on cervical root dentine. Imperva Bond produced a relatively high tensile bond strength to all regional areas. SEM showed that the thickness of the resin-infiltrated layer formed by All Bond 2 in root dentine was less than coronal areas. Resin infiltration with Imperva Bond was always less than 0.5 μm. The results suggest that high TBS values can be obtained with minimal resin infiltration in root dentine. Copyright © 1996 Elsevier Science Ltd.

    DOI: 10.1016/0300-5712(95)00102-6

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  • Transmission Electron Microscopic Characterization of Hypersensitive Human Radicular Dentin

    M. Yoshiyama, Y. Noiri, K. Ozaki, A. Uchida, Y. Ishikawa, H. Ishida

    Journal of Dental Research   69 ( 6 )   1293 - 1297   1990

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    Transmission electron microscopy (TEM) and x-ray microanalysis (XMA) were used for the study of the ultrastructure of the lumens of dentinal tubules in superficial layers of dentin specimens obtained by use of a new biopsy technique from both hypersensitive and naturally desensitized areas of exposed root surfaces, in vivo. The TEM images showed clearly that the lumens of most of the tubules were occluded with mineral crystals in naturally desensitized areas, but such lumens were empty and surrounded with peritubular and intertubular dentin in hypersensitive areas. Moreover, electron-dense structures that lined peritubular dentin were observed in the empty lumens of dentinal tubules. © 1990, SAGE Publications. All rights reserved.

    DOI: 10.1177/00220345900690061401

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  • Scanning Electron Microscopic Characterization of Sensitive vs. Insensitive Human Radicular Dentin

    M. Yoshiyama, J. Masada, A. Uchida, H. Ishida

    Journal of Dental Research   68 ( 11 )   1498 - 1502   1989

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    Language:English  

    Our aim was to investigate the structural changes of dentinal tubules in specimens obtained from both hypersensitive and naturally desensitized areas in wedge-shaped defects on the same exposed cervical dentin surface of a hypersensitive tooth. A new biopsy technique that makes use of a hollow, cylindrical diamond bur was designed so that specimens from exposed root dentin of vital teeth could be obtained. Twenty-two dentin biopsy pairs were divided into two groups
    one was prepared for scanning electron microscopy (SEM) and the other for microradiography (MR). Small hypersensitive areas were identified by a scratch test on exposed human dentin in vivo. SEM observation of the dentin biopsies showed that the orifices of many dentinal tubules in hypersensitive areas were open and that membranous structures appeared on the walls of dentinal tubules. In naturally desensitized areas on the same dentin surface, most of the dentinal tubules were obturated with rhombohedral crystals of all sizes
    membranous structures were not observed in these tubules. These results showed that hypersensitivity occurred on the exposed dentin when most of the tubular orifices were open. © 1989, SAGE Publications. All rights reserved.

    DOI: 10.1177/00220345890680110601

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  • Scanning Electron Microscopic Characterization of Sensitive vs. Insensitive Human Radicular Dentin

    M. Yoshiyama, J. Masada, A. Uchida, H. Ishida

    Journal of Dental Research   68 ( 11 )   1498 - 1502   1989

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    Language:English  

    Our aim was to investigate the structural changes of dentinal tubules in specimens obtained from both hypersensitive and naturally desensitized areas in wedge-shaped defects on the same exposed cervical dentin surface of a hypersensitive tooth. A new biopsy technique that makes use of a hollow, cylindrical diamond bur was designed so that specimens from exposed root dentin of vital teeth could be obtained. Twenty-two dentin biopsy pairs were divided into two groups
    one was prepared for scanning electron microscopy (SEM) and the other for microradiography (MR). Small hypersensitive areas were identified by a scratch test on exposed human dentin in vivo. SEM observation of the dentin biopsies showed that the orifices of many dentinal tubules in hypersensitive areas were open and that membranous structures appeared on the walls of dentinal tubules. In naturally desensitized areas on the same dentin surface, most of the dentinal tubules were obturated with rhombohedral crystals of all sizes
    membranous structures were not observed in these tubules. These results showed that hypersensitivity occurred on the exposed dentin when most of the tubular orifices were open. © 1989, SAGE Publications. All rights reserved.

    DOI: 10.1177/00220345890680110601

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Presentations

  • 新規2ステップシステムにおけるボンド塗布後のエアーブロー圧が象牙質接着性に及ぼす影響

    大原直子、小野瀬里奈、吉山昌宏

    第155回日本歯科保存学会秋季学術大会  2021.10.28  日本歯科保存学会

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    Event date: 2021.10.28

    Language:Japanese   Presentation type:Poster presentation  

    Venue:新潟市、オンライン  

  • 新規2ステップボンディング材の象牙質への接着耐久性

    大原直子、小野瀬里奈、吉山昌宏

    第154回日本歯科保存学会春季学術大会  2021.6.10  日本歯科保存学会

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    Language:Japanese   Presentation type:Poster presentation  

    Venue:鹿児島市、オンライン  

  • 構造色発色フロアブルコンポジットレジンの色調適合性

    小野瀬里奈、大原直子、吉山昌宏

    第153回日本歯科保存学会秋季学術大会  2020.11.16  日本歯科保存学会

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    Venue:オンライン  

  • 口腔乾燥症モデル作成のための基礎的研究

    第147回  2017 

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  • Influence of 10-MDP on the bond strength of resin cement

    Brazil-Japan Joint Research Workshop on Adhesive Dentistry  2017 

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  • 直接覆髄にBMP配合アルギン酸ゲルを用いた場合の硬組織反応

    日本再生歯科医学会  2017 

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  • コンポジットレジンの硬化前の汚染のSS-OCT

    第147回  2017 

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  • 漂白歯面変化のSS-OCT評価

    第147回日本歯科保存学会  2017 

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  • 充填用コンポジットレジンの色調に関する研究

    第146回日本歯科保存学会春季学術大会  2017 

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  • Assessment of surface contamination of uncured composite resin using SS-OCT

    Brazil-Japan Joint Research Workshop on Adhesive Dentistry  2017 

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  • 頭頸部がんに対する放射線治療後に多発性のう蝕を発症した一例

    第144回日本歯科保存学会春季学術大会  2016 

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  • 咬耗面積・接触面積・咬合接触点による咬耗症例の解析

    第145回日本歯科保存学会秋季学術大会  2016 

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  • 知覚過敏抑制材塗布後のレジン象牙質接着界面の観察

    第143回日本歯科保存学会秋季大会  2015 

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  • 一液性処理材の歯質接着強さ

    第142回日本歯科保存学会春季学術大会  2015 

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  • 歯面処理方法の違いが新規ワンステップボンディング材の象牙質微小引張り強さに及ぼす影響について

    第142回日本歯科保存学会秋季学術大会  2015 

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  • 光重合型レジン強化型ケイ酸カルシウム覆髄材の窩洞洗浄処理の違いによる封鎖性への影響

    第143回日本歯科保存学会秋季大会  2015 

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  • セルフアドヒーシブセメント中のMDP濃度が接着強さの及ぼす影響

    第143回日本歯科保存学会秋季大会  2015 

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  • 新規光硬化型動揺歯固定材料の接着強さと接着耐久性の評価

    第140回日本歯科保存学会春季学術大会  2014 

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  • j自己接着性フルアブルコンポジットレジンの人工酸蝕歯に対する引張り接着強度

    第141回日本歯科保存学会秋季学術大会  2014 

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  • 新規ワンステップボンディング材における象牙質接着強さについて

    第141回日本歯科保存学会秋季学術大会  2014 

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  • 裏層材の象牙質窩洞適合性:テフロンモールドに生じる間隙と接着強さの影響

    第141回日本歯科保存学会秋季学術大会  2014 

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  • Actinomyces種3菌種による歯根象牙質う蝕の誘発

    第140回日本歯科保存学会春季学術大会  2014 

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  • セルフアドヘッシヴ・レジンセメントの劣化加速試験後の機械的特性

    第33回日本接着歯学会学術大会  2014 

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  • レジンセメントの象牙質接着性: Dual-cure vs. self-cure

    第140回日本歯科保存学会春季学術大会  2014 

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  • フロワブルコンポジットレジンの硬化初期の動向:5級窩洞適合性,歯質接着性および曲げ特性からの検討

    日本歯科保存学会2013年度春季学術大会(138回)  2013 

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  • 高粉液比型グラスアイオノマーセメントの硬化初期のI級窩洞適合性と機械的強さの検討

    第139回日本歯科保存学会学術大会  2013 

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  • MDPおよびフッ化ナトリウムの配合が試作セルフアドヒーシブレジンセメントの吸水量および溶解量に及ぼす影響

    第139回日本歯科保存学会学術大会  2013 

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  • 新規光硬化型動揺歯固定材料の耐着色性の評価

    第24回日本歯科審美学会学術大会  2013 

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  • 歯科用象牙質接着材の細胞毒性と細胞回復度

    第139回日本歯科保存学会学術大会  2013 

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  • 多用途型試作歯面処理材の象牙質接着強さ

    第32回日本接着歯学会学術大会  2013 

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  • 細菌バイオミネラリゼーション誘導の試み

    第139回日本歯科保存学会学術大会  2013 

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  • 多用途型歯面処理材の象牙質接着強さ

    第139回日本歯科保存学会学術大会  2013 

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  • 象牙質知覚過敏抑制材がセルフエッチング接着システムの接着性に及ぼす影響

    第139回日本歯科保存学会学術大会  2013 

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  • Resin adhesion to caries-infected dentin

    歯科材料アカデミー(ADM)2013学術大会  2013 

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  • セルフアドヘッシヴ・レジンセメントのサーマルサイクル付加後のジルコニアに対する接着強さと曲げ特性

    第32回日本接着歯学会学術大会  2013 

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  • 象牙質知覚過敏抑制材の歯ブラシ摩耗と耐着色性の評価

    第136回日本歯科保存学会  2012 

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  • Mineralization of resin using experimental adhesives containing hydroxyapatite

    アメリカ国際歯科医学会  2012 

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  • 試作象牙質知覚過敏抑制材塗布後のレジン接着強さの影響について

    第30回日本接着歯学会  2012 

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  • 新規化学重合型プライマーの象牙質接着性

    第30回日本接着歯学会  2012 

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  • S-PRGフィラー配合試作レジンセメントの機械的性質

    第136回日本歯科保存学会  2012 

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  • 新規多用途型プライマーの歯面処理効果

    第136回日本歯科保存学会  2012 

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  • Effects of QAM on the fracture toughness of resin beams

    第90回国際歯科学会  2012 

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  • 各種象牙質知覚過敏抑制材の象牙質透過性の検討

    第59回日本歯科理工学会  2012 

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  • 号着用グラスアイオノマーセメントの初期硬化の動向

    第136回日本歯科保存学会  2012 

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  • フッ素含有知覚過敏抑制材の象牙質透過性の検討

    第136回日本歯科保存学会  2012 

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  • クロルヘキシジン配合セルフエッチングアドヒーシブのSmに対する抗菌性

    第136回日本歯科保存学会  2012 

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  • 新しい多用途型処理剤の接着強さからの検討

    第31回日本接着歯学会  2012 

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  • 超音波療法がBMPによる骨造成に及ぼす影響

    第10回日本再生歯科医学会  2012 

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  • 確かなエックス線診断と接着技法が破折歯を救う

    第136回日本歯科保存学会シンポジウム  2012 

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  • 最新の接着性レジンを用いた知覚過敏の治療

    第22回日本歯科医学会総会  2012 

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  • 骨髄間葉系幹細胞を用いたES細胞の誘導に関する研究

    第10回日本再生歯科医学会  2012 

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  • 象牙質知覚過敏抑制材の象牙質透過性の検討

    第10回日本再生歯科医学会  2012 

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  • コラーゲン固定化エチレンビニルアルコール共重合体添加石灰化誘導促進性接着材の骨に対する親和性

    第10回日本再生歯科医学会  2012 

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  • MDPおよびフッ化ナトリウムの配合が試作レジンセメントに及ぼす影響

    第31回日本接着歯学会  2012 

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  • 新規光硬化型動揺歯固定材料の接着強さと耐着色性の評価

    第31回日本接着歯学会  2012 

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  • 口腔連鎖球菌による歯根象牙質う蝕の誘発

    第137回日本歯科保存学会  2012 

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  • 号着用グラスアイオノマーセメントの初期硬化の動向

    第137回日本歯科保存学会  2012 

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  • ハイドロキシアパタイトを配合した試作接着システムの象牙質再石灰化についての検討

    第10回日本再生歯科医学会  2012 

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  • ハイドロキシアパタイトを配合した施策接着システムの象牙質再石灰化についての検討

    第9回日本再生歯科医学会学術大会  2011 

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  • 各種根管充填用シーラーを用いた根管封鎖性に関する研究

    第32回日本歯内療法学会  2011 

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  • 岡山大学病院における歯科医師臨床研修前後での臨床経験に関するアンケート調査

    第30回日本歯科医学教育学会総会  2011 

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  • 共焦点レーザー顕微鏡によるレジン象牙質接着界面の観察

    第134回日本歯科保存学会  2011 

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  • フッ素配合新規知覚過敏抑制材MSF-11の耐酸性について

    第134回日本歯科保存学会  2011 

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  • 直覆にコラーゲン固定化エチレンビニルアルコール共重合体添加石灰化誘導促進性接着剤を用いた象牙質再生療法

    第9回日本再生歯科医学会学術大会  2011 

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  • ヒト骨髄間葉系幹細胞を用いた象牙質・エナメル質複合体にの再生に関する研究

    第9回日本再生歯科医学会学術大会  2011 

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  • EDTA処理が根管象牙質のマトリックス分解活性に及ぼす影響

    第32回日本歯内療法学会  2011 

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  • 歯肉上皮細胞の歯周病原細菌取り込みに対するキトサンの影響

    第64回日本細菌学会中国四国支部総会  2011 

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  • 新規支台築造用レジンコアシステムに関する研究

    第135回日本歯科保存学会  2011 

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  • Er.YAGレーザー照射が象牙質ゼラチナーゼ活性に及ぼす影響

    第135回日本歯科保存学会  2011 

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  • Shear bond strengths to uncut enamel using new self-etching primer

    国際歯科医学会第89回世界大会  2011 

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  • MDPおよびフッ化ナトリウムの配合が試作レジンセメントの象牙質接着強さに及ぼす影響

    第134回日本歯科保存学会  2011 

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  • 表面歯質損失症候群の診断・治療法の開発

    第134回日本歯科保存学会  2011 

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  • セルフアドヒーシブレジンセメントにおける前処理が微小引張接着強さに及ぼす影響

    第134回日本歯科保存学会  2011 

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  • アスコルビン酸ナトリウム処理が漂白後のエナメル質接着に及ぼす影響

    第28回日本接着歯学会学術大会  2010 

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  • 共焦点レーザー顕微鏡を用いたレジンー象牙質接着界面の観察

    第28回日本接着歯学会  2010 

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  • ヒト骨髄間葉系幹細胞を用いた象牙質・エナメル質複合体の再生に関する研究全能性の同定のための遺伝子発現比較分析

    第8回日本再生歯科医学会  2010 

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  • オール・イン・ワン・アドヒーシブ前処理がレジンセメントの象牙質接着強さに及ぼす影響

    第132回日本歯科保存学会  2010 

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  • Water Sorption/Solubility Characteristics of Quaternary Ammonium Methacrylate-Containing Resins

    88nd International Association for Dental Research  2010 

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  • Tensile Strengths of Human Normal and Carious

    88nd International Association for Dental Research  2010 

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  • Effects of ultrasound on bone formation induced by BMP-2

    88nd International Association for Dental Research  2010 

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  • 浸漬溶液の違いがサーマルサイクル負荷後の象牙質接着強さに及ぼす影響

    第132回日本歯科保存学会  2010 

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  • 歯質界面表面損失症候群の診断・治療法のアンチエイジング歯学の確立

    第133回日本歯科保存学会  2010 

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  • 最新の自己接着性レジンに関する研究

    第133回日本歯科保存学会  2010 

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  • 新規科学重合型プライマー(DBC-510)の象牙質接着性

    第133回日本歯科保存学会  2010 

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  • 物性の異なる修復材料のサーマルサイクリング後の象牙質接着強さ

    第133回日本歯科保存学会  2010 

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  • 超音波がBMP骨膜注入後の骨形成に及ぼす影響

    第8回日本再生歯科医学会  2010 

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  • キトサンオリゴマーを配合した接着性レジンセメントの抗菌性の検討

    第8回日本再生歯科医学会  2010 

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  • A basic syudy: Bond strengths and bio-compatibility of experimental mineralization accelerationg adhesives containing collagen-immobilized poly ethylene-co-vinyl alcohol(EVA+C)

    K. Takahashi, M. Yoshiyama et al

    第二回岡山医療教育国際シンポジウム(岡山大学開学60周年記念事業)  2009.4 

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  • PCRサーマルサイクラーおよび従来型のサーマルサイクル付加後の象牙質接着強さ

    第131回日本歯科保存学会 2009年度秋季学術大会  2009 

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  • BMPによる骨形成に対するCO2レーザーの影響

    第7回日本再生歯科医学会  2009 

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  • ヒト骨髄間葉系幹細胞を用いた象牙質再生に関する研究

    第7回日本再生歯科医学会学術大会・総会  2009 

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  • 各種漂白剤処理後の時間経過がエナメル質接着におよぼす影響

    第130回日本歯科保存学会春期学術大会  2009 

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  • 術者の経験が接着性レジンの象牙質への接着強さに及ぼす影響

    第130回日本歯科保存学会  2009 

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  • Development of Adhesive Dental Material Inducing Hard Tissue Formation-Characteristics of Mineral Trioxide Aggregate and Super-Bond Sealer Mixture-

    第30回日本歯内療法学会  2009 

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  • 新規PMMA系レジンセメントのサーマルサイクル負荷後の象牙質接着強さ

    第27回日本接着歯学会  2009 

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  • 再石灰化象牙質に対するワンステップ接着システムの接着性

    第27回日本接着歯学会学術大会  2009 

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  • Bond Strength and Bio-Compatibility of Experimental Adhesives Added Collagen Immobilized Poly Ethylene-co-Vinyl Alcohol (EVA+C)

    2009 Autumn Scientific Meeting (the 132nd) and The 11th Joint-Scientific Meeting between KACD & JSCD  2009 

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  • 新規象牙質知覚過敏抑制材に関する微細形態学的研究

    第131回日本歯科保存学会  2009 

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  • オフィスホワイトニング後の時間経過がエナメル質に対する各種接着システムの接着強さに及ぼす影響

    第131回日本歯科保存学会  2009 

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  • 新規ボンディング材Absolute3の接着性について

    第54回日本歯科理工学会学術講演会  2009 

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  • Dentin bond strengths after thermal cycling using PCR thermal cycler or conventional thermal cycler

    2009 Autumn Scientific Meeting (the 132th) The 11th Joint Meeting between KACD and JSCD KDCD  2009 

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  • 術者の経験が接着性レジンの象牙質への接着強さに及ぼす影響

    第30回岡山歯学会総会ならびに学術集会  2009 

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  • セルフエッチングプライマーによる象牙質中のゼラチン分解酵素の活性化

    第30回岡山歯学会総会ならびに学術集会  2009 

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  • 各種漂白剤処理後のエナメル質に対する接着性の検討

    松崎久美子、吉山昌宏他

    第127回日本歯科保存学会  2008.6 

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  • Tensile strength of mineralized/demineralized human normal and carious dentin

    The 10th joint Meeting between KACD and JSCD  2008 

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  • CAD/CAM修復におけるレジンセメントの接着強さの評価

    第21回日本歯科医学会総会  2008 

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  • Tensile strength of mineralized/demineralized human normal and carious dentin

    The 10th joint meeting between KACD and JSCD  2008 

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  • Effects of BMP-2 on bone formation at palatal subperiosteal sites

    86th Internatioinal Association of Dental Research  2008 

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  • オフィスホワイトニング後のエナメル質に対する各種接着システムの接着強さ

    第127回日本歯科保存学会  2008 

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  • Er:YAGレーザー照射象牙質の元素分析に関する研究

    第127回日本歯科保存学会  2008 

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  • 新規PMMA系レジンセメントのサーマルサイクル後の象牙質接着強さ

    第127回日本歯科保存学会  2008 

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  • 接着性レジンセメントの錬和方法のセラミックに対する接着強さに及ぼす影響

    第51回日本歯科理工学会学術講演会  2008 

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  • Effects of incorporating chlorhexidine into all-in-one adhesives

    86th International Association for Dental Reserch  2008 

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  • 各種処理剤を塗布した歯面への接着

    第127回日本歯科保存学会  2008 

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  • Durability of Resina Bonded to Water Vs.Ethanol-Saturated Acid-Etched Dentin

    37th American Association for Dental Research  2008 

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  • Present status and future of self-etching system

    International Symposium for Adhesive Dentistry 2008 in Kanazawa  2008 

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  • Effect of irrigation with sodium hypochlorite on dentin bond strength of newly developed MMA-based resin cement

    International Symposium for Adhesive Dentistry 2008 in Kanazawa  2008 

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  • Tooth Wearの発症機序の解明とアンチエイジング歯学の展開

    第24回歯科医学を中心とした総合的な研究を推進する集い  2008 

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  • コラーゲン固定化エチレン・ビニルアルコール共重合体(EVA+C)添加試作石灰化誘導促進性接着材の接着強さと生体親和性に関する基礎的研究

    第129回日本歯科保存学会  2008 

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  • 試作ワンステップボンディング材GBA400の歯髄表面粗さの違いによる接着強さへの影響

    第129回日本歯科保存学会  2008 

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  • The current trends and future of minimal intervention dentistry with functional adhesive resins

    The 12th china international symposium on dental equipment, technology and products  2008 

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  • Resin adhesion to caries-affected and caries-infected dentin

    The Third international congress on adhesive dentistry  2008 

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  • Er:YAGレーザーに照射したう蝕影響象牙質へのレジン接着強さに関する研究

    第129回歯科保存学会  2008 

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  • Mechanical properties of one-step adhesive-polymers in dry vs.wet

    86th International Association for Dental Research  2008 

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  • Effects of eccentric vs concentric specimen attachment on micro-tansile bond strengths using 1 step self-etching adhesive

    The 3rd International Congress on Adhesive Dentistry  2008 

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  • 超音波治療とBMP-2を用いた骨再生療法

    第6回日本再生歯科医学会学術大会  2008 

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  • Dentin-regeneration by the Dentin Research

    86th International Association for Dental Reserch  2008 

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  • Er:YAGレーザー照射後の齲蝕影響象牙質に対する接着強さに関する研究

    第10回Er:YAGレーザー臨床研究会  2007 

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  • 再石灰化水溶液中におけるコンポジットレジンの物性に関する研究

    第126回日本歯科保存学会  2007 

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  • 直接覆髄にrhBMP-2配合アルギン酸ゲルを用いた場合の組織反応

    第126回日本歯科保存学会  2007 

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  • ワンステップボンディングシステムの歯根部人工脱灰象牙質に対する接着性

    第25回日本接着歯学会  2007 

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  • ワンボトルボンディング材アブソリュート2を用いた汚染歯質に対する接着

    第25回日本接着歯学会  2007 

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  • グルタールアルデヒド法を用いたEr:YAGレーザー照射象牙質のコンポジットレジン接着性改善に関する研究

    第10回Er:YAGレーザー臨床研究会  2007 

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  • 着色歯に対するホワイトニング効果および後戻りに関する研究

    第126回日本歯科保存学会  2007 

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  • 新規接着性モノマーを用いた1ステップ接着システムの接着性に関する研究

    第126回日本歯科保存学会  2007 

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  • 還元剤処理が次亜塩素酸ナトリウム処理歯冠部象牙質に対する4-META/MMA-TBBレジンの接着性に及ぼす影響

    第126回日本歯科保存学会  2007 

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  • 新規1液型ボンディング材IMB-3接着システムの象牙質接着性

    第25回日本接着歯学会  2007 

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  • Evaluation of dentine sealing using current coating materials.

    85th of general session of International Association of Dental Research  2007 

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  • ホワイトニングを行った歯の形態学的研究

    第18回日本審美歯科学会  2007 

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  • セルフエッチング接着システムの再石灰化象牙質に対する接着性(第2報)

    第127回日本歯科保存学会  2007 

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  • 象牙質透過性に及ぼすコーティング法の影響

    第127回日本歯科保存学会  2007 

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  • 岡山大学病院歯科臨床研修における保存領域診療研修の状況について

    第127回日本歯科保存学会  2007 

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  • Effects of incorporating into chlorhexidine self-etching primers

    International Dental Material Congress  2007 

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  • 一液型1ステップ接着システムの採取後の放置時間が象牙質耐久性に及ぼす影響

    第26回日本接着歯学会  2007 

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  • セルフアドヒーシブレジンセメントにおける前処理の効果

    第26回日本接着歯学会  2007 

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  • pH緩衝能を有するフッ素徐放性レジンの開発

    第127回日本歯科保存学会  2007 

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  • リコンビナントヒトBMP-2配合アルギン酸ゲルを用いた骨再生療法の開発

    第5回日本再生歯科医学会  2007 

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  • ワンステップ接着システムの齲蝕象牙質への接着

    第24回日本接着歯学会  2006 

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  • 臼歯直接修復用コンポジットレジンの物性に関する検討

    第125回日本歯科保存学会  2006 

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  • ワンボトルワンステップ接着システムの採取後の放置時間が象牙質接着性に及ぼす影響

    第125回日本歯科保存学会  2006 

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  • 歯内療法の原点:歯髄保存を考える

    第27回日本歯内療法学会  2006 

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  • ワンボトルワンステップ接着システムの歯面処理時間が歯質接着性に及ぼす影響

    第24回日本接着歯学会  2006 

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  • 生体吸収性創傷被覆材による象牙質歯髄複合体の再生

    第125回日本歯科保存学会  2006 

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  • スキャホールドがrhBMP-2による骨形成に及ぼす影響

    第27回岡山歯学会  2006 

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  • Effects of hydrophilicity of resins on microtensile bond strengths

    35th Annual Meeting & Exhibition of the AADR  2006 

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  • 硬組織再生:象牙質再生療法の開発

    日本再生歯科医学会シンポジウム  2006 

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  • 歯科臨床におけるMI臨床の広がり:齲蝕象牙質への接着ストラテジー

    第二回国際歯科シンポジウム  2006 

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  • 新規カルボン酸系およびホスホン酸系接着モノマーを配合した接着システムの接着耐久性

    第124回日本歯科保存学会  2006 

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  • リコンビナントヒトBMP-2配合アテロコラーゲンスポンジによる骨形成反応

    第47回日本歯科理工学会  2006 

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  • 新規充填用レジンの開発

    歯科における産学連携インサテライトオフィイス大阪  2006 

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  • Activation of gelatinolytic/collagenolytic activity in dentin by self-etching adhesives

    35th of Annual Meeting of the AADR  2006 

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  • Bonding of adhesives to bur-cut, Er:YAG laser-irradiated and ultrasonic-excavated dentin

    84th International Association for Dental Research  2006 

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  • アルギン酸ゲルをスキャホールドとしたrhBMP-2移植による組織反応

    第4回日本再生歯科医学会  2006 

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  • 新規レジンセメントの象牙質接着強さに対する接着システムの影響

    第124回日本歯科保存学会  2006 

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  • 還元剤処理が次亜塩素酸ナトリウム処理歯冠部象牙質に対する4-META/MMA-TBBレジンの接着性に及ぼす影響

    第124回日本歯科保存学会  2006 

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  • Odontoblast differentiation-dependent gene expression of bone marrow mesenchymal stem cells

    84th of International Association for Dental Research  2006 

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  • Effects of remineralization-accelerating agent in odontoblast-like cell(MDPC-23)

    84th International Association fro Dental Research  2006 

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  • 象牙質接着におけるレジンの親水性の影響

    第125回日本歯科保存学会  2006 

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  • セルフエッチング接着システムの再石灰化象牙質に対する接着性

    第125回日本歯科保存学会  2006 

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  • セルフエッチングプライマーによる象牙質中のゼラチン分解酵素の活性化

    第48回日本歯科理工学会  2006 

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  • 生体吸収性創傷被覆材Kurabio gelに対する象牙質歯髄複合体の反応

    第4回日本再生歯科医学会  2006 

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  • 根充革命ー密着から接着へ

    第27回岡山歯学会ランチョンセミナー  2006 

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  • Effects of eccentric/concentric specimen attachment on micro-tensile bond strength

    83nd International Association for Dental Research, 2005/3/12, Baltimore  2005 

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  • リコンビナントヒトBMP-2の濃度がラットの骨形成に及ぼす影響

    日本歯科保存学会・2005年春季学会(第122回)  2005 

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  • セルフエッチングプライマー接着システムの歯面処理時間が歯質接着性に及ぼす影響

    日本歯科保存学会・2005年春季学会(第122回)  2005 

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  • ボンディングレジンの弾性率に対する吸水の影響

    第46回日本歯科理工学会,歯科材料・器械, 24(5), 391, 2005/9/16, 長崎  2005 

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  • Er:YAGレーザー照射象牙質に対する象牙質接着システムの引張り接着強さにおけるGLUMA&reg; Desensitizerの影響 -長期水中浸漬後の引張り接着強さ-

    第46回日本歯科理工学会  2005 

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  • 生体吸収性創傷被覆材を用いた象牙質・歯髄複合体の再生

    第3回日本再生歯科医学会, 2005/9/3, 東京  2005 

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  • 保存修復学と理工学のコラボレーション:次世代の接着歯学の確立

    平成17年度日本歯科理工学会近畿・中四国支部夏季セミナー, 2005/8/20, 安芸(広島)  2005 

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  • ホームブリーチングが象牙質のレジン接着強さに及ぼす影響

    第16回日本歯科審美学会, 2005/10/8-9, 大阪  2005 

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  • Identification of caspase-6 as a candidate tumor suppressor gene at 4q25 in oral cancer

    第1回口腔顔面頭蓋再生研究国際シンポジウム,第5回日本外傷歯学会,第14回硬組織再生生物学会, (P-84), 2005/9/19, 岡山  2005 

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  • Fine deletional mapping of chromosome 4q22-35 region in oral cancer

    第1回口腔顔面頭蓋再生研究国際シンポジウム,第5回日本外傷歯学会,第14回硬組織再生生物学会, (P-53), 2005/9/18, 岡山  2005 

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  • フッ素徐放性接着システムが象牙質に及ぼす影響-二次齲蝕抑制と再石灰化-

    第1回口腔顔面頭蓋再生研究国際シンポジウム,第5回日本外傷歯学会,第14回硬組織再生生物学会, 2005/9/18, 岡山  2005 

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  • 試作フロアブルレジンのフロー性におけるフィラー配合量およびモノマー組成の影響

    第123回日本歯科保存学会,日本歯科保存学会雑誌, 48(秋季特別号), 30, 2005/11/24, 東京  2005 

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  • Biocompatibility testing of hydroxyapatite using human gingival epithelial cells

    Japanese Association for Dental Research 53rd annual meeting, 89(Abstract 21), 2005/11/27, Okayama  2005 

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  • 岡山大学医学部・歯学部附属病院における歯科関連のインシデントレポートの分析

    第56回中国地区歯科医学大会, 2005/10/16, 岡山  2005 

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  • ワンステップボンディングシステムのう蝕象牙質への接着強さ

    第123回日本歯科保存学会,日本歯科保存学会雑誌, 48(秋季特別号), 171, 2005/11/25, 東京  2005 

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  • グラスアイオノマーセメントの粉液比がフッ素徐放性および曲げ強さに及ぼす影響

    第123回日本歯科保存学会,日本歯科保存学会雑誌, 48(秋季特別号), 168, 2005/11/25, 東京  2005 

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  • 歯科用レジンの弾性率に対する吸水の影響

    日本歯科保存学会・2005年春季学会(第122回)  2005 

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  • ワンステップボンディングシステムの歯冠部および歯根部象牙質に対する接着耐久性

    日本歯科保存学会・2005年春季学会(第122回)  2005 

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  • Adhesion of 4-META/MMA-TBB to carious dentin

    83nd International Association for Dental Research, 2005/3/12, Baltimore  2005 

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  • Effects of improved evaporation technique of single step adhesive

    83nd International Association for Dental Research, 2005/3/12  2005 

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  • Bond strength of caries-affected dentin using thin-film bonding agent

    82nd International Association for Dental Research, 2004/3/10-13, Honolulu,  2005 

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  • Bond Strength to Carious Dentin Using Thin-film Bonding Agents

    83nd International Association for Dental Research, 2005/3/10,  2005 

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  • Bond strength of thin-film bonding agent to caries-affected dentin

    第2回国際接着歯学会,第23回日本接着歯学会  2005 

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  • Microtensile bond strength of current adhesive systems to Er:YAG-laser-treated dentin

    第2回国際接着歯学会,第23回日本接着歯学会  2005 

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  • Fluoride release and neutralizing effect by resin-based materials

    83nd International Association for Dental Research, 2005/3/12, Baltimore  2005 

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  • 試作シングルステップボンディングシステムのエナメル質および象牙質への接着性

    第120回日本歯科保存学会, 日本歯科保存学会雑誌, 47(春季特別号), 115, 2004/6/11, 東京  2004 

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  • Expression of dopamine receptor mRNA in the rat area postrema

    The 2nd International Dental Science Symposium in Seoul National University and Okayama University (第2回日韓歯学国際シンポジウム), 2004/12/18, Okayama  2004 

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  • Expression of dopamine receptor mRNA in the rat area postrema

    Japanese Association for Dental Research 52nd annual meeting, 82(Abstract 35), 2004/11/28, Tokyo  2004 

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  • う蝕影響象牙質の形態と接着メカニズム

    第121回日本歯科保存学会,日本歯科保存学会雑誌, 47(秋季特別号), 151, 2004/11/19, 長崎,ポスター  2004 

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  • ワンステップボンディングシステムのう蝕象牙質への接着性

    第121回日本歯科保存学会,日本歯科保存学会雑誌, 47(秋季特別号), 11, 2004/11/18, 長崎  2004 

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  • 新規ワンボトルワンステップ接着システムの齲蝕象牙質接着性に関する研究

    第121回日本歯科保存学会,日本歯科保存学会雑誌, 47(秋季特別号), 10, 2004/11/18, 長崎  2004 

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  • う蝕象牙質へのレジン接着メカニズム

    第20回日本歯科医学会,日本歯科医師会雑誌,57(4), 130(abst 238), 2004/10/30,横浜  2004 

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  • う蝕影響象牙質への薄膜ボンディング材の接着性能

    第121回日本歯科保存学会,日本歯科保存学会雑誌, 47(秋季特別号), 150, 2004/11/19, 長崎  2004 

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  • 審美修復材料の表面改質によるin vitroでの細菌付着抑制効果

    第121回日本歯科保存学会,日本歯科保存学会雑誌, 47(秋季特別号), 89, 2004/11/18, 長崎  2004 

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  • 各種フロアブルレジンのフロー,X線造影性および物性に関する研究

    第121回日本歯科保存学会,日本歯科保存学会雑誌, 47(秋季特別号), 79, 2004/11/18, 長崎  2004 

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  • One step象牙質接着システムにおける操作時間が象牙質浸透性に及ぼす影響

    第121回日本歯科保存学会,日本歯科保存学会雑誌, 47(秋季特別号), 16, 2004/11/18, 長崎  2004 

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  • 樹脂含浸齲蝕象牙質の性質

    第120回日本歯科保存学会,日本歯科保存学会雑誌, 47(春季特別号), 65, 2004/6/10, 東京  2004 

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  • Modified Sealed Restorationに応用する接着システムの開発 -人工脱灰象牙質への接着におけるHEMA含有前処理溶液の溶媒の影響-

    第43回日本歯科理工学会,歯科材料・器械, 23(2), 152, 2004/4/11,  2004 

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  • Expression of osteonectin induced by CTGF in human pulp cells

    82nd International Association for Dental Research, 2004/3/10-13, Honolulu  2004 

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  • Effects of multiple all-in-one adhesive coatings on dentin bonding

    82nd International Association for Dental Research, 2004/3/10-13, Honolulu  2004 

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  • 象牙質再生療法の開発-CTGF刺激による培養ヒト歯髄細胞のosteonectinの発現に対するアルギン酸ゲルの影響-

    第120回日本歯科保存学会,日本歯科保存学会雑誌, 47(春季特別号), 90, 2004/6/10, 東京  2004 

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  • Resin adhesion to endodontically-treated root dentin

    82nd International Association for Dental Research, 2004/3/10-13, Honolulu  2004 

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  • 試作シングルステップボンディングシステムのう蝕象牙質に対する接着性

    第22回日本接着歯学会, 接着歯学, 21(4), 350-351, 2004/1/25, 鹿児島  2004 

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  • レジンからのフッ素徐放制御に関する研究 -コポリマー被覆フッ化物配合レジンのpH応答性-

    第20回日本歯科医学会,日本歯科医師会雑誌,57(4), 103(abst 57), 2004/10/30,横浜  2004 

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  • pH応答型フッ素徐放性レジンの開発-フッ化物の三級アミン処理がpH応答性および物性に与える影響-

    第44回日本歯科理工学会,歯科材料・器械, 23(5), 443, 2004/9/25, 京都  2004 

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  • 2004年度シンポジウム:新しい器材を用いた次世代の接着修復 次世代接着修復は器材と手技のコラボレーションから 多様な臨床被着面に接着するシングルステップシステムの開発

    日本接着歯学会2004年度シンポジウム, 接着歯学, 22(2), 142, 2004/9/12, 東京  2004 

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  • 接着性モノマーが脱灰象牙質の再石灰化に及ぼす影響

    第2回日本再生歯科医学会, 日本再生歯科医学会誌, 2(1), 81?, 2004/9/4, 札幌  2004 

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  • 試作シングルステップボンディングシステムの根面う蝕象牙質への接着性

    第120回日本歯科保存学会,日本歯科保存学会雑誌, 47(春季特別号), 114, 2004/6/11, 東京  2004 

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  • HEMA/1,2-propanediol含有溶液による前処理が齲蝕象牙質への接着に及ぼす影響

    第120回日本歯科保存学会,日本歯科保存学会雑誌, 47(春季特別号), 37, 2004/6/11, 東京  2004 

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  • All-in-one接着システムにおける多層コーティングによる象牙質接着への影響

    第2回日本再生歯科医学会,日本再生歯科医学会誌, 2(1), 81?, 2004/9/4, 札幌  2004 

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  • アルギン酸ゲルが培養ヒト歯髄細胞のosteonectinおよびosteocalcinの発現に及ぼす影響

    第2回日本再生歯科医学会, 日本再生歯科医学会誌, 2(1), 81?, 2004/9/4, 札幌  2004 

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  • 象牙質再建・再生法への新バイオマテリアルの応用

    第2回日本再生歯科医学会, 日本再生歯科医学会誌, 2(1), 81?, 2004/9/4, 札幌  2004 

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  • フッ素作用時期のエナメル質耐酸性に及ぼす影響

    第119回日本歯科保存学会  2003 

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  • 審美修復用レジンセメントの象牙質接着性

    第14回日本歯科審美学会  2003 

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  • 象牙質再生療法の開発 -CTGF刺激によるヒト歯髄細胞におけるオステオネクチン の発現の解析-

    第119回日本歯科保存学会  2003 

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  • 齲蝕象牙質への接着性レジン拡散性に関する研究

    118回日本歯科保存学会  2003 

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  • Bonding of all-in-one adhesive systems to carious dentin

    81st International Association for Dental Research  2003 

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  • ウェットボンディングシステムを応用したレジンセメントの接着性能について

    第41回日本歯科理工学会  2003 

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  • 酸処理象牙質の収縮動態について(第2報)接触および非接触型プローブによる測定

    第41回日本歯科理工学会  2003 

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  • 新しい根管充填材の開発―最新の接着システムを応用した根管治療後の象牙質接着性―

    第21回日本接着歯学会  2003 

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  • 象牙質再生療法の開発 ―アルギン酸ゲルの培養歯髄細胞に対する影響―

    第第118回日本歯科保存学会  2003 

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  • ラミネートベニア修復長期症例における破折への対応

    第118回日本歯科保存学会  2003 

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  • Single component self-etching adhesiveの象牙質接着 ―第一報 健全及びう蝕影響象牙質への初期接着性―

    第118回日本歯科保存学会  2003 

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  • 新しい根管充填材の開発 ―最新の接着システムを応用した根管治療後の象牙質接着性―

    第21回日本接着歯学会  2003 

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  • コラーゲンを固定化したエチレンビニールアルコールの象牙質再生療法への応用の可能性

    日本再生歯科医学会  2003 

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  • rhBMP-2誘導性硬組織形成に対するphosphophorynの影響

    日本再生歯科医学会  2003 

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  • pH応答型フッ素徐放性レジンの開発

    第42回日本歯科理工学会  2003 

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  • Effect of remineralization accelerating solution to dentin bonding

    FDI Annual World Dental Congress  2003 

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  • アルコキシシランの応用による審美修復材料の表面改質

    第119回日本歯科保存学会  2003 

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  • CTGF刺激によるヒト歯髄細胞におけるオステオネクチンの発現の解析

    日本再生歯科医学会  2003 

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  • OSCEにおけるコミュニケーション能力の評価について

    日本歯科医学教育学会総会・学術大会22回  2003 

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  • Determination of total and free fluoride ions released from resin-based composites containing fluoride

    81st International Association for Dental Research  2003 

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  • Development of dentin regeneration therapy: expression of type I collagen and alkaline phosphatase induced by CTGF in human cultured dental pulp cells

    81st International Association for Dental Research  2003 

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  • 窩洞形成時疼痛の中枢抑制機構の解明 -ラット最後野におけるドーパミン受容体の遺伝子解析-

    第116回日本歯科保存学会  2002 

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  • 接着性レジンに対する齲蝕象牙質の透過性に関する研究

    第117回日本歯科保存学会  2002 

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  • モディファイド・シールド・レストレーションに関する細菌学的研究 ―光重合型ボンディング材で封じ込められた細菌の生存性―

    第117回日本歯科保存学会  2002 

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  • レジンセメントの象牙質接着強さの時間的推移について

    第39回日本歯科理工学会  2002 

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  • 象牙質再生療法の開発 -ヒト培養歯髄におけるCTGF刺激によるalkaline phosphataseの発現-

    第116回日本歯科保存学会  2002 

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  • フルオロアパタイト析出能を有する接着修復法の開発 -試作再石灰化溶液(RE-01)の象牙質接着に及ぼす影響-

    第116回日本歯科保存学会  2002 

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  • Micro-tensile bond strength of self-etching adhesive systems to coronal caries-dentin

    The first International Congress on Adhesive Dentistry(第1回国際接着歯学会)(第20回日本接着歯学会)  2002 

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  • Influence of dentin conditioning using amino acid monomer on morphological structure of collagen and adhesion

    The first International Congress on Adhesive Dentistry(第1回国際接着歯学会)(第20回日本接着歯学会)  2002 

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  • フッ素徐放性を付与した試作ワン・ステップ・レジンシステムの象牙質接着性の検討

    第116回日本歯科保存学会  2002 

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  • Effect of Ultrasonic Caries Excavation on Dentin Bonding Promoted by Two Self-Etching Primer Systems

    Fourth International Congress on Dental Materials  2002 

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  • Effect of HEMA pretreatment on the bonding of the self-etching adhesive system to artificial demineralized dentin

    Fourth International Congress on Dental Materials  2002 

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  • The theory behind and clinical application of adhesive technology

    FDI Annual World Dental Congress  2002 

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  • 象牙質再生療法の開発 -ヒト培養歯髄におけるCTGF刺激によるType 1 collagen, ALPの発現-

    第11回硬組織生物学会総会  2002 

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  • フルオロアパタイト析出能を有する接着修復法の開発 ―試作再石灰化溶液(RE-02)の象牙質接着に及ぼす影響―

    第117回日本歯科保存学会  2002 

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  • 接着システムがフッ素徐放性修復材料の二次齲蝕抑制効果に及ぼす影響

    第117回日本歯科保存学会  2002 

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  • コンポジットレジンへの細菌付着メカニズムの解明―共焦点レーザー顕微鏡による分析―

    第23回岡山歯学会  2002 

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  • Controlled release of fluoride ion from the resin containing NaF coated with tertiary amine-TEGDMA copolymer.

    Fourth International Congress on Dental Materials  2002 

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  • リン酸処理時間が象牙質の脱灰コラーゲン層収縮および膨潤に及ぼす影響

    第40回日本歯科理工学会  2002 

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  • 新しいう蝕治療法を求めて:保存修復から象牙質再生への新展開

    第17回歯科医学を中心とした総合的な研究を推進する集い  2001 

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  • New technology for evaluating biofunctional adhesive resins

    Adhesive Dentistry Forum 2001 in Okayama  2001 

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  • Abnormal dentin as a bonding substrate: resin adhesion to carious and sclerotic dentin

    The International Conference on Dentin/Pulp Complex 2001  2001 

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  • 新規ウェットボンディングシステムの歯質接着性

    第19回日本接着歯学会  2001 

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  • 根面う蝕修復の新しい流れ -フロアブルレジンの接着性-

    第19回日本接着歯学会  2001 

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  • in vivo におけるイヌ象牙質への接着性レジンの接着強度の長期耐久性

    硬組織生物学会  2001 

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  • All-in-one adhesive systemの象牙質接着における各種conditioning法の効果

    第115回日本歯科保存学会  2001 

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  • フッ素徐放性修復材料のエナメル質耐酸性向上効果に及ぼすagingの影響

    第38回日本歯科理工学会  2001 

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  • 高分子被覆フッ化物配合によるレジンからのフッ素徐放制御

    第22回岡山歯学会総会  2001 

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  • 接着性レジン修復の現状とその新展開

    第22回岡山歯学会総会  2001 

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  • 象牙質再生療法の開発 -コラーゲン固定化エチレン-ビニルアルコール共重合体(EVA)へのヒト歯髄由来細胞培養-

    第115回日本歯科保存学会  2001 

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  • 齲蝕病巣下のdentin/pulp complexにおける病理組織学的検討

    第115回日本歯科保存学会  2001 

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  • HEMAの象牙質脱灰コラーゲン石灰化に対する影響 -象牙質最表層部微細構造の検討-

    第114回日本歯科保存学会  2001 

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  • う蝕象牙質へのレジン浸透性 -in vitroモデル解析-

    第37回日本歯科理工学会  2001 

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  • アミノ酸誘導体の分子構造が象牙質接着に及ぼす影響

    第37回日本歯科理工学会  2001 

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  • Modified sealed restoration combined with antibacterial adhesive system

    International Symposium "self-etching primer : current status and its evolution"  2001 

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  • GIOMER(リアクトマー)の象牙質接着性と短期臨床経過

    第114回日本歯科保存学会  2001 

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  • 各種接着システムの象牙質接着性に及ぼすEDTA処理の影響

    第114回日本歯科保存学会  2001 

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  • ABFを応用した根面う蝕象牙質へのMRS法の展開

    第114回日本歯科保存学会  2001 

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  • Effect of EDTA condition on dentin adhesion by self-etching promer

    79th International Association for Dental Research, 2001/6/29, Chiba, poster Journal of Dental Research  2001 

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  • Confocal laser-scanning microscope analysis of Actinomyces viscosus adherence to composite

    79th International Association for Dental Research  2001 

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  • Adhesion of oral streptococci to esthetic restorative materials in vitro

    79th International Association for Dental Research  2001 

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  • Effect of remineralization-accelerating agent to dentin bonding

    The International Conference on Dentin/Pulp Complex 2001  2001 

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  • Distribution of calbindin D-28k and osteonectin in human carious teeth

    The International Conference on Dentin/Pulp Complex 2001  2001 

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  • Effect of fluoride-releasing adhesives to dentin -inhibition of secondary caries and remineralization of decalcified dentin-

    2nd Giomer International Meeting  2001 

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  • Effect of fluoride-releasing liner on decalcified dentin

    79th International Association for Dental Research, 2001/6/29, Chiba, poster Journal of Dental Research  2001 

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  • シラン処理フッ化物を配合した長期フッ素徐放性レジンがエナメル質の脱灰抵抗性に及ぼす影響

    第36回日本歯科理工学会  2001 

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  • 抗菌性およびフッ素徐放能を有する試作ボンディングシステムの歯質接着性について

    第113回日本歯科保存学会  2000 

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  • New technology of evaluating biomaterials in dental field

    7th of International Conference on Composite Engineering  2000 

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  • MDPB配合試作接着システムの齲蝕象牙質中の嫌気性菌に対する効果について

    第113回日本歯科保存学会  2000 

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  • フッ素徐放性歯面処理材による脱灰象牙質の再石灰化

    第113回日本歯科保存学会  2000 

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  • HEMAは象牙質コラーゲンの石灰化誘導活性を増強させる

    第113回日本歯科保存学会  2000 

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  • 象牙質接着で生成する樹脂含浸層におけるN,O-diacryloxy tyrosineとN-acryloxy phenylalanineの効果

    第36回日本歯科理工学会  2000 

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  • A comparison of bacterial communities in carious dentine and plaque

    Japanese Association for Dental Research 48th annual meeting  2000 

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Awards

  • 日本歯科保存学会2020年度優秀論文賞

    2020.1   日本歯科保存学会  

    高橋圭、吉山昌宏

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    Award type:Honored in official journal of a scientific society, scientific journal 

  • 日本歯科保存学会2020年度学術賞

    2020.1   日本歯科保存学会  

    島田康史、吉山昌宏

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    Award type:Award from Japanese society, conference, symposium, etc. 

  • 日本再生歯科医学会学会功労賞

    2017  

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    Country:Japan

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  • 日本再生歯科医学会 優秀発表賞

    2012  

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    Country:Japan

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  • 日本再生歯科医学会 優秀発表賞

    2011  

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    Country:Japan

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  • 日本再生歯科医学会優秀発表賞

    2011  

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    Country:Japan

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  • 日本歯科保存学会 デンツプライ賞

    2009  

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    Country:Japan

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  • 日本再生歯科医学会 優秀ポスター賞

    2008  

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    Country:Japan

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  • 日本再生歯科医学会優秀論文賞

    2007  

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    Country:Japan

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  • 第五回日本再生歯科医学会発表優秀賞

    2007  

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    Country:Japan

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  • 日本歯科保存学会デンツプライ賞(保存修復・口頭発表)

    2007  

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    Country:Japan

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  • 日本歯科保存学会デンツプライ賞

    2004  

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    Country:Japan

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  • 接着歯学フォーラム・インプレッシブ・スピーカー賞

    1998  

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    Country:Japan

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  • 国際歯科研究学会歯髄研究部会海外発表者賞 (IADR Pulp Biology group : Travel Award)

    1993  

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Research Projects

  • 新規コンポジットレジンの開発とその評価

    Grant number:新規コンポジットレジンの開発  2021.04 - 2022.03

    株式会社トクヤマデンタル  受託研究 

    吉山昌宏

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    Authorship:Principal investigator  Grant type:Collaborative (industry/university)

    Grant amount:\500000 ( Direct expense: \400000 、 Indirect expense:\100000 )

  • 新規コンポジットレジンの開発とその評価

    Grant number:新規コンポジットレジンの開発  2020.04 - 2021.03

    株式会社トクヤマデンタル 

    吉山昌宏

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    Authorship:Principal investigator  Grant type:Collaborative (industry/university)

    Grant amount:\500000 ( Direct expense: \400000 、 Indirect expense:\100000 )

  • 硝酸カリウムによる神経鈍麻効果の評価

    Grant number:硝酸カリウム配合含嗽剤の知覚  2020.04 - 2021.03

    株式会社アース製薬  受託研究 

    吉山昌宏

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2000000 ( Direct expense: \1600000 、 Indirect expense:\400000 )

  • 新規コンポジットレジンの開発とその評価

    Grant number:新規コンポジットレジンの開発  2019.04 - 2020.03

    株式会社トクヤマデンタル  受託研究 

    吉山昌宏

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    Authorship:Principal investigator  Grant type:Collaborative (industry/university)

    Grant amount:\500000 ( Direct expense: \400000 、 Indirect expense:\100000 )

 

Class subject in charge

  • Practices of cavity preparation, filling technique and metal inlay restoration (2021academic year) 2-4 semesters  - [第2学期]金1,金2,金3, [第3学期]金5,金6,金7, [第4学期]金5,金6,金7

  • Practices of cavity preparation, filling technique and metal inlay restoration (2021academic year) 2-4 semesters  - [第2学期]金1,金2,金3, [第3学期]金5,金6,金7, [第4学期]金5,金6,金7

  • Practices of cavity preparation, filling technique and metal inlay restoration (2021academic year) 2-4 semesters  - [第2学期]金1,金2,金3, [第3学期]金5,金6,金7, [第4学期]金5,金6,金7

  • Research Presentation in Oral Functional Reconstruction (2021academic year) special  - その他

  • Clinical training: Advanced Esthetic Dentistry (2021academic year) special  - その他

  • Lecture and Research Projects: Advanced Esthetic Dentistry (2021academic year) special  - その他

  • Clinical training: Advanced Adhesive Dentistry (2021academic year) special  - その他

  • Lecture and Research Projects: Advanced Adhesive Dentistry (2021academic year) special  - その他

  • Research Projects and Practicals:Operative Dentistry I (2021academic year) special  - その他

  • Lecture and Research Projects: Operative Dentistry I (2021academic year) special  - その他

  • Research Projects and Practicals:Operative Dentistry II (2021academic year) special  - その他

  • Lecture and Research Projects: Operative Dentistry II (2021academic year) special  - その他

  • Diagnosis and treatment of Dentin/Pulp Complex (2021academic year) Fourth semester  - 金4

  • Practice of the diagnosis and treatment of Dentin/Pulp Complex (2021academic year) Fourth semester  - 金5

  • Clinical metal-based materials (2021academic year) Second semester  - 木1,木2

  • Clinical metal-based materials (2021academic year) Second semester  - 木1,木2

  • Cariology and Clinical adhesive materials (2021academic year) 1st semester  - 木1,木2

  • Cariology and Clinical adhesive materials (2021academic year) 1st and 2nd semester  - [第1学期]木1,木2, [第2学期]金4

  • Cariology and Clinical adhesive materials (2021academic year) 1st and 2nd semester  - [第1学期]木1,木2, [第2学期]金4

  • Practices of cavity preparation, filling technique and metal inlay restoration (2020academic year) 2-4 semesters  - [第2学期]金1,金2,金3, [第3学期]金5,金6,金7, [第4学期]金5,金6,金7

  • Practices of cavity preparation, filling technique and metal inlay restoration (2020academic year) 2-4 semesters  - [第2学期]金1,金2,金3, [第3学期]金5,金6,金7, [第4学期]金5,金6,金7

  • Practices of cavity preparation, filling technique and metal inlay restoration (2020academic year) 2-4 semesters  - [第2学期]金1,金2,金3, [第3学期]金5,金6,金7, [第4学期]金5,金6,金7

  • Research Presentation in Oral Functional Reconstruction (2020academic year) Year-round  - その他

  • Oral Functional Reconstruction (2020academic year) Year-round  - その他

  • Clinical training: Advanced Esthetic Dentistry (2020academic year) special  - その他

  • Lecture and Research Projects: Advanced Esthetic Dentistry (2020academic year) special  - その他

  • Clinical training: Advanced Adhesive Dentistry (2020academic year) special  - その他

  • Lecture and Research Projects: Advanced Adhesive Dentistry (2020academic year) special  - その他

  • Research Projects and Practicals:Operative Dentistry I (2020academic year) special  - その他

  • Lecture and Research Projects: Operative Dentistry I (2020academic year) special  - その他

  • Research Projects and Practicals:Operative Dentistry II (2020academic year) special  - その他

  • Lecture and Research Projects: Operative Dentistry II (2020academic year) special  - その他

  • Diagnosis and treatment of Dentin/Pulp Complex (2020academic year) Fourth semester  - 金4

  • Practice of the diagnosis and treatment of Dentin/Pulp Complex (2020academic year) Fourth semester  - 金5

  • Clinical metal-based materials (2020academic year) Second semester  - 木1,木2

  • Clinical metal-based materials (2020academic year) Second semester  - 木1,木2

  • Cariology and Clinical adhesive materials (2020academic year) 1st semester  - 木1,木2

  • Cariology and Clinical adhesive materials (2020academic year) 1st and 2nd semester  - [第1学期]木1,木2, [第2学期]金4

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