記述言語：英語  

We presented a case of primary bone lymphoma (PBL) which demonstrated fever of unknown origin. Although the diagnosis of PBL is difficult, up to 11% of patients with fever of unknown origin were later diagnosed with PBL, which suggests that there may be many cases of misdiagnosis. This case study emphasizes the importance of careful diagnosis for fever of unknown origin especially when the patient has bone pain.

DOI： 10.1002/jgf2.529

PubMed

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記述言語：日本語   出版者・発行元：(一社)日本内分泌学会  

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記述言語：日本語   出版者・発行元：(一社)日本内分泌学会  

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

We presented a case of primary bone lymphoma (PBL) which demonstrated fever of unknown origin. Although the diagnosis of PBL is difficult, up to 11% of patients with fever of unknown origin were later diagnosed with PBL, which suggests that there may be many cases of misdiagnosis. This case study emphasizes the importance of careful diagnosis for fever of unknown origin especially when the patient has bone pain.

DOI： 10.1002/jgf2.529

その他リンク： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9249926/

記述言語：日本語   出版者・発行元：(一社)日本内科学会  

J-GLOBAL

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

Introduction The long-term clinical course, prognosis, and optimal management of symptoms and conditions after the acute phase of coronavirus disease 2019 (COVID-19) remain to be elucidated. The purpose of this study was to clarify the characteristics of patients referred to a COVID-19 aftercare (CAC) clinic established at a tertiary academic hospital in Japan. Methods This study was a descriptive case series study. All patients who visited the CAC clinic between February 15 and September 17 in 2021 were included. Patients' background, chief complaints, and clinical courses after the onset of COVID-19 were described. Results A total of 87 Japanese patients (median age, 40.0 years; interquartile range [IQR], 26.5-53.0 years; 52.9% women) were referred to the CAC clinic. The median interval between the onset of COVID-19 and the visit to the clinic was 79.0 (IQR, 52.5-112.0) days. Referral sources were hospitals (36 patients), clinics (47 patients), a local healthcare center (3 patients), and other (1 patient). The most common chief complaint was general fatigue (50.4%) followed by dysosmia (28.7%), dysgeusia (26.4%), hair loss (18.4%), headache (17.2%), dyspnea (16.1%), and dyssomnia (13.1%). Respiratory symptoms were common in the early stages of the disease but were less common as the chief complaints when visiting the clinic. On the other hand, neurological, psychiatric, and extremity symptoms were predominant one month after the onset of COVID-19. Conclusions Regardless of the severity in the acute phase, patients visiting our CAC clinic suffered from a variety of symptoms. General physicians skilled in using a comprehensive approach would be optimal to see patients with such complex symptoms.

DOI： 10.7759/cureus.18568

その他リンク： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8571943/

担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

The gold standard for the diagnosis of coronavirus disease 2019 (COVID-19) is a nucleic acid detection test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may occasionally reveal false-positive or false-negative results. Herein, we describe a case of a patient infected with human coronavirus NL63 (HCoV-NL63) who was falsely diagnosed with COVID-19 using the Ampdirect™ 2019-nCoV detection kit (Shimadzu Corporation, Japan) and SARS-CoV-2 Detection Kit (TOYOBO co., ltd.), and was admitted to a COVID-19 hospital ward. We suspected a cross-reaction between HCoV-NL63 and SARS-CoV-2; however, the reported genome sequences of HCoV-NL63 and N1/N2 primers for SARS-CoV-2 do not correspond. Thus, the PCR result was supposed to be a false positive possibly due to contamination or human error. Although the issue of a false-negative result has been the focus of much attention to prevent the spread of the disease, a false positive is fraught with problems as well. Physicians should recognize that unnecessary isolation violates human rights and a careful diagnosis is indispensable when the results of laboratory testing for COVID-19 are unclear. Generally, in cases such as a duplicate PCR test was partially positive, either N1 or N2 alone was positive, PCR testing for two or more target regions resulted in a positive only for single region, a high cycle threshold >35 was obtained, a false positive should be suspected. Especially, when these conditions coincide, we should recognize the high likelihood of a false positive.

DOI： 10.1016/j.jiac.2021.05.001.

その他リンク： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106895/

担当区分：筆頭著者,　最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

We have presented a case of barium appendicitis, which is a rare complication of barium enema studies. Barium sulfate is used widely for gastrointestinal radiographic studies and is associated with few complications. Clinicians need to be fully aware of this complication.

DOI： 10.1002/ccr3.4583

その他リンク： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299263/

担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) mainly affects young adults and can have a potential impact on social functioning. As this syndrome is associated with endothelial dysfunction, the heart can be damaged via ischemia due to endothelial damage. This might potentially lead to heart failure, which accounts for approximately 20% of deaths among patients with ME/CFS. While cardiac ischemia is thought be a pathophysiologically important manifestation of this syndrome, this is not yet reported. Herein, we present a case of a young female with newly diagnosed vasospastic or microvascular angina and concurrent exacerbation of ME/CFS severity. Her anginal symptoms, including exertional chest pain and transient chest discomfort, mimicked those of ME/CFS but were relieved after the administration of a calcium channel blocker. We emphasize the possibility of concurrent angina and exacerbation of ME/CFS and the importance of detecting cardiac ischemia to avoid unfavorable outcomes.

DOI： 10.3390/diagnostics11030460

その他リンク： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001656/

担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

Physicians should be aware of the risk of malignancy in patients with toxic multinodular goiter. Radionuclide scan cannot be used to predict the malignant potential of thyroid nodules. A comprehensive evaluation of imaging studies is needed.

DOI： 10.1002/ccr3.3843.

その他リンク： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981636/

担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

Anorexia nervosa (AN) is occasionally complicated with hypoglycemic coma, which may cause sudden death by unknown mechanisms. We present the case of a 36-year-old woman with recurrent comas and a nineteen-year history of AN. She was found in a coma with remarkable hypoglycemia (28 mg/dL). Her BMI was 11.1 kg/m2. Endocrine workup revealed extremely low serum levels of glucagon, IGF-I and insulin. Asymptomatic hypoglycemia occurred with liver injury in the refeeding process. An aberrant glucose metabolism due to liver damage might have been involved in her susceptibility to hypoglycemia. This case suggests a possible mechanism of hypoglycemic coma in AN.

DOI： 10.18926/AMO/62776.

その他リンク： https://ousar.lib.okayama-u.ac.jp/ja/62776

担当区分：筆頭著者,　最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

We have presented a case of Salmonella-induced infective aortic aneurysm in which the presence of peri-aortic gas was a clue for diagnosis. The disease is clinically infrequent but potentially has a high mortality rate. Clinicians should consider this fatal disease from any trivial findings.

DOI： 10.1002/ccr3.3367.

その他リンク： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7752411/

担当区分：筆頭著者,　最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

We herein report a teenage girl who had been taking oral contraceptive pills for three months and complained of left lower abdominal pain that had continued for two months. A physical examination indicated anterior cutaneous nerve entrapment syndrome (ACNES), although no abnormality was found in various biochemical and imaging examinations. The pain was only transiently ameliorated by trigger-point injection, and neurectomy surgery was eventually effective. Sex steroids can be involved in the progress of local tissue edema causing ACNES. ACNES should be considered in cases of abdominal pain in patients taking oral contraceptives.

DOI： 10.2169/internalmedicine.1361-18.

その他リンク： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548911/

担当区分：筆頭著者,　最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.2169/internalmedicine.1692-18.

その他リンク： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522395/

記述言語：英語   掲載種別：研究論文（学術雑誌）  

AIM: To examine the change in vertebral bone mineral density (BMD) using abdominal computed tomography in patients treated for sepsis. METHODS: A single-center, retrospective, observational study was undertaken to evaluate BMD after critical care at Okayama Saiseikai General Hospital (Okayama, Japan) from January 2016 to April 2018. Sepsis was defined as an absolute increase of ≥2 in Sequential Organ Failure Assessment score in the intensive care unit or high care unit. Bone mineral density was evaluated in Hounsfield units (HU) by computed tomography. Patients were divided into groups based on the presence or absence of osteoporosis, which was defined as average vertebral body HU <110. Paired t-tests were used to compare the mean BMD of each vertebra between before and after critical care. We also analyzed accidental bone fracture events after discharge. The survival rate was analyzed as an outcome using the Kaplan-Meier method. RESULTS: Fifty-two of 188 patients met the inclusion criteria. We found significant differences between admission and follow-up vertebral BMD values in the spine at the thoracic 12, lumbar 1-5, and sacrum 1 levels (P < 0.05), especially in the non-osteoporosis groups. No difference in mortality was observed between patients with osteoporosis and those without. Two of 19 patients with osteoporosis developed a bone fracture. CONCLUSION: We found that sepsis was associated with loss in BMD following critical care.

DOI： 10.1002/ams2.401

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担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

Aim: To examine the change in vertebral bone mineral density (BMD) using abdominal computed tomography in patients treated for sepsis.

Methods: A single-center, retrospective, observational study was undertaken to evaluate BMD after critical care at Okayama Saiseikai General Hospital (Okayama, Japan) from January 2016 to April 2018. Sepsis was defined as an absolute increase of ≥2 in Sequential Organ Failure Assessment score in the intensive care unit or high care unit. Bone mineral density was evaluated in Hounsfield units (HU) by computed tomography. Patients were divided into groups based on the presence or absence of osteoporosis, which was defined as average vertebral body HU <110. Paired t-tests were used to compare the mean BMD of each vertebra between before and after critical care. We also analyzed accidental bone fracture events after discharge. The survival rate was analyzed as an outcome using the Kaplan-Meier method.

Results: Fifty-two of 188 patients met the inclusion criteria. We found significant differences between admission and follow-up vertebral BMD values in the spine at the thoracic 12, lumbar 1-5, and sacrum 1 levels (P < 0.05), especially in the non-osteoporosis groups. No difference in mortality was observed between patients with osteoporosis and those without. Two of 19 patients with osteoporosis developed a bone fracture.

Conclusion: We found that sepsis was associated with loss in BMD following critical care.

DOI： 10.1002/ams2.401

その他リンク： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442538/

担当区分：筆頭著者,　最終著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.2169/internalmedicine.1320-18

その他リンク： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367079/

担当区分：最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

We retrospectively analyzed the cases of 148 febrile patients whose body temperature (BT) was ≥ 37.5°C at our hospital. We categorized them into seven groups; those with bacterial and viral infection, nonspecific inflammation, neoplasm, connective tissue disease (CTD), drug-induced disease, and unidentified causes. Our analysis revealed that the patient's BT at the 1st visit (BT-1st visit) and highest BT during the febrile period (BT-max) differed significantly among all categories except neoplasm. The greatest difference between BT-1st visit and BT-max was highest in the CTD group (1.5°C). Positive correlations of heart rate and C-reactive protein (CRP) level with BT-max and a negative correlation between serum sodium level with BT-max were uncovered. The serum thyroid-stimulating hormone (TSH) level and the ratio of TSH/free thyroxine were negatively correlated with BT-max, especially in the viral infection group, suggesting the existence of occult thyrotoxicosis in accord with a febrile condition, possibly leading to febrile tachycardia. A febrile gap between BT-1st visit and BT-max (except in the neoplasm group) was shown, in which BT-max was correlated with thyroid function. Clinicians should recognize the fluctuation of BT when diagnosing febrile patients, and tachycardia in such febrile patients may be, at least in part, associated with subclinical thyroid dysfunction.

DOI： 10.18926/AMO/56242.

その他リンク： https://ousar.lib.okayama-u.ac.jp/ja/56242

記述言語：日本語   出版者・発行元：(一社)日本病院総合診療医学会  

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担当区分：筆頭著者,　最終著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

A 77-year-old female with renal dysfunction, hypercalcemia, and hypercalciuria was presented. Systemic investigations including renal biopsy showed that the patient had Fanconi syndrome secondary to renal sarcoidosis. Treatment with 25 mg per day of prednisolone was initiated and her condition improved. Complication of Fanconi syndrome in patients with sarcoidosis is extremely rare. Although the pathological mechanism is still unknown, corticosteroid therapy was effective for ameliorating proteinuria, glycosuria, hypercalciuria, and aminoaciduria.

DOI： 10.3109/14397595.2014.1002163

その他リンク： https://academic.oup.com/mr/article-lookup/doi/10.3109/14397595.2014.1002163

記述言語：英語   掲載種別：研究論文（学術雑誌）  

A 77-year-old female with renal dysfunction, hypercalcemia, and hypercalciuria was presented. Systemic investigations including renal biopsy showed that the patient had Fanconi syndrome secondary to renal sarcoidosis. Treatment with 25 mg per day of prednisolone was initiated and her condition improved. Complication of Fanconi syndrome in patients with sarcoidosis is extremely rare. Although the pathological mechanism is still unknown, corticosteroid therapy was effective for ameliorating proteinuria, glycosuria, hypercalciuria, and aminoaciduria.

DOI： 10.3109/14397595.2014.1002163

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総ページ数：p265-499   記述言語：日本語

CiNii Books

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J-GLOBAL

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出版者・発行元：株式会社医学書院  

DOI： 10.11477/mf.3103900887

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出版者・発行元：株式会社医学書院  

DOI： 10.11477/mf.3103900888

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記述言語：英語  

Introduction The long-term clinical course, prognosis, and optimal management of symptoms and conditions after the acute phase of coronavirus disease 2019 (COVID-19) remain to be elucidated. The purpose of this study was to clarify the characteristics of patients referred to a COVID-19 aftercare (CAC) clinic established at a tertiary academic hospital in Japan. Methods This study was a descriptive case series study. All patients who visited the CAC clinic between February 15 and September 17 in 2021 were included. Patients' background, chief complaints, and clinical courses after the onset of COVID-19 were described. Results A total of 87 Japanese patients (median age, 40.0 years; interquartile range [IQR], 26.5-53.0 years; 52.9% women) were referred to the CAC clinic. The median interval between the onset of COVID-19 and the visit to the clinic was 79.0 (IQR, 52.5-112.0) days. Referral sources were hospitals (36 patients), clinics (47 patients), a local healthcare center (3 patients), and other (1 patient). The most common chief complaint was general fatigue (50.4%) followed by dysosmia (28.7%), dysgeusia (26.4%), hair loss (18.4%), headache (17.2%), dyspnea (16.1%), and dyssomnia (13.1%). Respiratory symptoms were common in the early stages of the disease but were less common as the chief complaints when visiting the clinic. On the other hand, neurological, psychiatric, and extremity symptoms were predominant one month after the onset of COVID-19. Conclusions Regardless of the severity in the acute phase, patients visiting our CAC clinic suffered from a variety of symptoms. General physicians skilled in using a comprehensive approach would be optimal to see patients with such complex symptoms.

DOI： 10.7759/cureus.18568

PubMed

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担当区分：最終著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(公社)日本医師会  

国際化を背景に、在日外国人も新型コロナウイルス感染症(COVID-19)に罹患しているが、本邦でその診療上の課題に関する文献はない。2020年2月からの1年間に岡山大学病院総合内科・総合診療科に入院した、外国人COVID-19患者全5人を対象として、患者背景や言語状況、入院中のトラブルや解決策について診療録から抽出した。全員が日本語の書字・読字が全く不能であり、うち1人は日常会話も困難で電話医療通訳サービスを要したが、担当医や看護師に加えて、国際診療支援センターや臨床栄養部、精神科などと連携することで隔離解除まで入院継続が可能であった。COVID-19では本人の希望に沿わない入院や予定外入院のため、通常の外国人診療に比して負担・課題が大きい。特に言語面での制約は、隔離管理下での意思疎通や同意書の取得などの面で障壁となることが明らかとなった。院内組織の連携と、病院を超えた情報共有による病軟な対応が重要である。

記述言語：英語   出版者・発行元：Okayama University Medical School  

Anorexia nervosa (AN) is occasionally complicated with hypoglycemic coma, which may cause sudden death by unknown mechanisms. We present the case of a 36-year-old woman with recurrent comas and a nineteen-year history of AN. She was found in a coma with remarkable hypoglycemia (28 mg/dL). Her BMI was 11.1 kg/m2. Endocrine workup revealed extremely low serum levels of glucagon, IGF-I and insulin. Asymptomatic hypoglycemia occurred with liver injury in the refeeding process. An aberrant glucose metabolism due to liver damage might have been involved in her susceptibility to hypoglycemia. This case suggests a possible mechanism of hypoglycemic coma in AN.

DOI： 10.18926/amo/62776

PubMed

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CiNii Books

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その他リンク： https://search.jamas.or.jp/link/ui/2022228485

記述言語：日本語   出版者・発行元：日本医師会  

CiNii Article

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その他リンク： https://search.jamas.or.jp/link/ui/2022039263

記述言語：英語  

We have presented a case of barium appendicitis, which is a rare complication of barium enema studies. Barium sulfate is used widely for gastrointestinal radiographic studies and is associated with few complications. Clinicians need to be fully aware of this complication.

DOI： 10.1002/ccr3.4583

PubMed

CiNii Article

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記述言語：英語  

The gold standard for the diagnosis of coronavirus disease 2019 (COVID-19) is a nucleic acid detection test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may occasionally reveal false-positive or false-negative results. Herein, we describe a case of a patient infected with human coronavirus NL63 (HCoV-NL63) who was falsely diagnosed with COVID-19 using the Ampdirect™ 2019-nCoV detection kit (Shimadzu Corporation, Japan) and SARS-CoV-2 Detection Kit (TOYOBO co., ltd.), and was admitted to a COVID-19 hospital ward. We suspected a cross-reaction between HCoV-NL63 and SARS-CoV-2; however, the reported genome sequences of HCoV-NL63 and N1/N2 primers for SARS-CoV-2 do not correspond. Thus, the PCR result was supposed to be a false positive possibly due to contamination or human error. Although the issue of a false-negative result has been the focus of much attention to prevent the spread of the disease, a false positive is fraught with problems as well. Physicians should recognize that unnecessary isolation violates human rights and a careful diagnosis is indispensable when the results of laboratory testing for COVID-19 are unclear. Generally, in cases such as a duplicate PCR test was partially positive, either N1 or N2 alone was positive, PCR testing for two or more target regions resulted in a positive only for single region, a high cycle threshold >35 was obtained, a false positive should be suspected. Especially, when these conditions coincide, we should recognize the high likelihood of a false positive.

DOI： 10.1016/j.jiac.2021.05.001

PubMed

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その他リンク： https://search.jamas.or.jp/link/ui/2022102510

担当区分：最終著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

担当区分：最終著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

担当区分：最終著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   出版者・発行元：(一社)日本内分泌学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本内分泌学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本内分泌学会  

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記述言語：英語  

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) mainly affects young adults and can have a potential impact on social functioning. As this syndrome is associated with endothelial dysfunction, the heart can be damaged via ischemia due to endothelial damage. This might potentially lead to heart failure, which accounts for approximately 20% of deaths among patients with ME/CFS. While cardiac ischemia is thought be a pathophysiologically important manifestation of this syndrome, this is not yet reported. Herein, we present a case of a young female with newly diagnosed vasospastic or microvascular angina and concurrent exacerbation of ME/CFS severity. Her anginal symptoms, including exertional chest pain and transient chest discomfort, mimicked those of ME/CFS but were relieved after the administration of a calcium channel blocker. We emphasize the possibility of concurrent angina and exacerbation of ME/CFS and the importance of detecting cardiac ischemia to avoid unfavorable outcomes.

DOI： 10.3390/diagnostics11030460

PubMed

CiNii Article

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記述言語：英語  

Physicians should be aware of the risk of malignancy in patients with toxic multinodular goiter. Radionuclide scan cannot be used to predict the malignant potential of thyroid nodules. A comprehensive evaluation of imaging studies is needed.

DOI： 10.1002/ccr3.3843

PubMed

CiNii Article

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担当区分：最終著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本内分泌学会  

記述言語：日本語   出版者・発行元：(一社)日本内分泌学会  

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記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本総合病院精神医学会  

記述言語：日本語   出版者・発行元：(一社)日本総合病院精神医学会  

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担当区分：最終著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本内分泌学会  

記述言語：日本語   出版者・発行元：(一社)日本内分泌学会  

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記述言語：英語  

We have presented a case of Salmonella-induced infective aortic aneurysm in which the presence of peri-aortic gas was a clue for diagnosis. The disease is clinically infrequent but potentially has a high mortality rate. Clinicians should consider this fatal disease from any trivial findings.

DOI： 10.1002/ccr3.3367

PubMed

CiNii Article

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記述言語：英語   出版者・発行元：The Japanese Society of Internal Medicine  

We herein report a teenage girl who had been taking oral contraceptive pills for three months and complained of left lower abdominal pain that had continued for two months. A physical examination indicated anterior cutaneous nerve entrapment syndrome (ACNES), although no abnormality was found in various biochemical and imaging examinations. The pain was only transiently ameliorated by trigger-point injection, and neurectomy surgery was eventually effective. Sex steroids can be involved in the progress of local tissue edema causing ACNES. ACNES should be considered in cases of abdominal pain in patients taking oral contraceptives.

DOI： 10.2169/internalmedicine.1361-18

PubMed

CiNii Article

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その他リンク： https://search.jamas.or.jp/link/ui/2020190177

記述言語：日本語   出版者・発行元：(一社)日本病院総合診療医学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本病院総合診療医学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本病院総合診療医学会  

J-GLOBAL

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記述言語：英語   出版者・発行元：The Japanese Society of Internal Medicine  

DOI： 10.2169/internalmedicine.1692-18

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その他リンク： https://search.jamas.or.jp/link/ui/2020189984

担当区分：筆頭著者,　最終著者,　責任著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本内科学会  

記述言語：日本語   出版者・発行元：(一社)日本内科学会  

J-GLOBAL

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記述言語：英語   出版者・発行元：The Japanese Society of Internal Medicine  

DOI： 10.2169/internalmedicine.1320-18

PubMed

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担当区分：最終著者,　責任著者  

担当区分：最終著者  

記述言語：英語  

To clarify potential relationships between chief complaints of patients and laboratory data with a focus on aging-related changes, we retrospectively analyzed the data of 843 patients who visited a general medicine department for the first time. Their chief complaints were classified into 8 major symptoms: visceral pain, somatic pain, fever, cough, dizziness, fatigue, appetite loss, and edema. We compared the laboratory data obtained from the patients with complaints with the data of symptom-free (control) patients. The serum sodium and potassium levels in the fever group were decreased compared to those in the control group. In the fever group, the serum sodium level was inversely correlated with age. The ratio of serum urea nitrogen to creatinine (UN/Cr) was increased in the appetite-loss group. There were significant age-dependent increases in the UN/Cr ratio in the appetite-loss and edema groups. Of note, serum levels of free thyroxin were lower in the dizziness group compared to the control group. In addition, the free thyroxin level was inversely correlated with age in the dizziness group but not in the asymptomatic control group. Collectively, the results indicated that osmolality-related laboratory data are strongly associated with individual primary symptoms at the first visit regardless of the final diagnosis. The consideration of age-dependent changes of these markers is helpful for diagnosing latent disorders based on various primary symptoms.

DOI： 10.18926/amo/56372

PubMed

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その他リンク： https://search.jamas.or.jp/link/ui/2019286375

担当区分：最終著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本病院総合診療医学会  

記述言語：日本語   出版者・発行元：(一社)日本病院総合診療医学会  

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記述言語：英語  

We retrospectively analyzed the cases of 148 febrile patients whose body temperature (BT) was ≥ 37.5°C at our hospital. We categorized them into seven groups; those with bacterial and viral infection, nonspecific inflammation, neoplasm, connective tissue disease (CTD), drug-induced disease, and unidentified causes. Our analysis revealed that the patient's BT at the 1st visit (BT-1st visit) and highest BT during the febrile period (BT-max) differed significantly among all categories except neoplasm. The greatest difference between BT-1st visit and BT-max was highest in the CTD group (1.5°C). Positive correlations of heart rate and C-reactive protein (CRP) level with BT-max and a negative correlation between serum sodium level with BT-max were uncovered. The serum thyroid-stimulating hormone (TSH) level and the ratio of TSH/free thyroxine were negatively correlated with BT-max, especially in the viral infection group, suggesting the existence of occult thyrotoxicosis in accord with a febrile condition, possibly leading to febrile tachycardia. A febrile gap between BT-1st visit and BT-max (except in the neoplasm group) was shown, in which BT-max was correlated with thyroid function. Clinicians should recognize the fluctuation of BT when diagnosing febrile patients, and tachycardia in such febrile patients may be, at least in part, associated with subclinical thyroid dysfunction.

DOI： 10.18926/amo/56242

PubMed

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その他リンク： https://search.jamas.or.jp/link/ui/2019206207

記述言語：日本語   出版者・発行元：(一社)日本内分泌学会  

J-GLOBAL

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担当区分：筆頭著者,　最終著者,　責任著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本病院総合診療医学会  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本病院総合診療医学会  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本病院総合診療医学会  

記述言語：日本語   出版者・発行元：(一社)日本病院総合診療医学会  

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記述言語：日本語   出版者・発行元：(一社)日本病院総合診療医学会  

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記述言語：日本語   出版者・発行元：(一社)日本感染症学会  

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担当区分：筆頭著者,　最終著者,　責任著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本病院総合診療医学会  

担当区分：最終著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本病院総合診療医学会  

担当区分：最終著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本病院総合診療医学会  

記述言語：日本語   出版者・発行元：(一社)日本病院総合診療医学会  

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記述言語：日本語   出版者・発行元：(一社)日本病院総合診療医学会  

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記述言語：日本語   出版者・発行元：(一社)日本病院総合診療医学会  

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担当区分：最終著者  

担当区分：最終著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本内分泌学会  

担当区分：最終著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本内分泌学会  

記述言語：日本語   出版者・発行元：(一社)日本内分泌学会  

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担当区分：筆頭著者,　最終著者,　責任著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本病院総合診療医学会  

担当区分：最終著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本病院総合診療医学会  

担当区分：最終著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本病院総合診療医学会  

担当区分：最終著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本病院総合診療医学会  

担当区分：最終著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本病院総合診療医学会  

担当区分：最終著者   出版者・発行元：(一社)日本病院総合診療医学会  

記述言語：日本語   出版者・発行元：(一社)日本病院総合診療医学会  

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記述言語：日本語   出版者・発行元：(一社)日本病院総合診療医学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本病院総合診療医学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本病院総合診療医学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本病院総合診療医学会  

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記述言語：日本語   出版者・発行元：(一社)日本病院総合診療医学会  

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記述言語：日本語   出版者・発行元：(一社)日本病院総合診療医学会  

J-GLOBAL

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記述言語：日本語   出版者・発行元：(一社)日本病院総合診療医学会  

J-GLOBAL

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担当区分：最終著者   記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）   出版者・発行元：(一社)日本病院総合診療医学会  

開催年月日： 2021年4月9日 - 2021年4月10日

記述言語：日本語  

開催地：Web   国名：日本国  

開催年月日： 2021年2月19日 - 2021年2月28日

記述言語：日本語  

開催地：Web   国名：日本国  

開催年月日： 2021年2月19日 - 2021年2月28日

記述言語：日本語  

開催地：Web   国名：日本国  

開催年月日： 2021年2月17日

記述言語：日本語  

開催地：Web   国名：日本国  

開催年月日： 2021年2月17日

記述言語：日本語  

開催地：ホテルグランヴィア岡山   国名：日本国  

開催年月日： 2020年12月7日 - 2020年12月13日

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：Web   国名：日本国  

開催年月日： 2020年11月13日 - 2020年12月10日

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：Web   国名：日本国  

開催年月日： 2020年9月26日 - 2020年9月27日

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：ラフレさいたま   国名：日本国  

その他リンク： https://www.medicalonline.jp/meetings/detail?id=5168

開催年月日： 2020年9月26日 - 2020年9月27日

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：ラフレさいたま   国名：日本国  

その他リンク： https://www.medicalonline.jp/meetings/detail?id=5168

開催年月日： 2020年9月5日

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：Web   国名：日本国  

開催年月日： 2019年6月1日

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：岡山コンベンションセンターママカリフォーラム   国名：日本国  

開催年月日： 2019年4月26日 - 2019年4月28日

記述言語：日本語   会議種別：ポスター発表  

開催地：ポートメッセなごや   国名：日本国  

開催年月日： 2019年2月15日 - 2019年2月16日

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：沖縄科学技術大学院大学   国名：日本国  

その他リンク： https://www.youtube.com/watch?v=3GpYcmO23rE&ab_channel=%E3%82%A2%E3%82%AB%E3%83%8D%E3%82%AF%E3%83%AA%E3%82%A8%E3%83%BC%E3%82%B7%E3%83%A7%E3%83%B3%E6%B2%96%E7%B8%84MICE%E3%82%B5%E3%83%BC%E3%83%93%E3%82%B9

開催年月日： 2019年2月15日 - 2019年2月16日

記述言語：日本語  

開催地：沖縄科学技術大学院大学   国名：日本国  

その他リンク： https://www.youtube.com/watch?v=3GpYcmO23rE&ab_channel=%E3%82%A2%E3%82%AB%E3%83%8D%E3%82%AF%E3%83%AA%E3%82%A8%E3%83%BC%E3%82%B7%E3%83%A7%E3%83%B3%E6%B2%96%E7%B8%84MICE%E3%82%B5%E3%83%BC%E3%83%93%E3%82%B9

開催年月日： 2018年11月2日 - 2018年11月3日

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：福岡国際会議場   国名：日本国  

その他リンク： https://dm-net.co.jp/event/2018/028010.php

開催年月日： 2018年9月15日 - 2018年9月16日

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：じゅうろくプラザ 岐阜サテライトキャンパス   国名：日本国  

その他リンク： https://www.medicalonline.jp/meetings/detail?id=3546

開催年月日： 2018年8月17日 - 2018年8月19日

記述言語：日本語  

開催地：高知市桂浜　国民宿舎「桂浜荘」   国名：日本国  

開催年月日： 2018年5月19日

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：米子コンベンションセンター BiG SHiP   国名：日本国  

開催年月日： 2018年3月2日 - 2018年3月3日

開催地：別府国際コンベンションセンター   国名：日本国  

その他リンク： https://okayama-u-sougounaika.jp/2018/03/05/%E7%AC%AC16%E5%9B%9E-%E6%97%A5%E6%9C%AC%E7%97%85%E9%99%A2%E7%B7%8F%E5%90%88%E8%A8%BA%E7%99%82%E5%8C%BB%E5%AD%A6%E4%BC%9A%EF%BC%882018-03-02-03%EF%BC%89/

開催年月日： 2018年3月2日 - 2018年3月3日

記述言語：日本語   会議種別：ポスター発表  

開催地：別府国際コンベンションセンター   国名：日本国  

開催年月日： 2018年3月2日 - 2018年3月3日

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：別府国際コンベンションセンター   国名：日本国  

開催年月日： 2018年2月8日

記述言語：日本語   会議種別：公開講演，セミナー，チュートリアル，講習，講義等  

開催地：岡山大学医学部　管理棟8階　第10カンファレンスルーム   国名：日本国  

開催年月日： 2017年11月24日 - 2017年11月25日

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：神戸国際展示場   国名：日本国  

開催年月日： 2017年11月18日

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：島根大学医学部看護学科棟・講義棟   国名：日本国  

開催年月日： 2014年9月19日 - 2014年9月20日

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：高崎シティギャラリー   国名：日本国  

開催年月日： 2014年9月19日 - 2014年9月20日

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：高崎シティギャラリー   国名：日本国  

開催年月日： 2014年9月3日

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：岡山   国名：日本国