2021/04/08 更新

写真a

カタヤマ ユキトシ
片山 侑駿
KATAYAMA Yukitoshi
所属
自然科学学域 助教(特任)
職名
助教(特任)
プロフィール
魚類生理学、行動学の研究をしています。
外部リンク

研究分野

  • ライフサイエンス / 動物生理化学、生理学、行動学

 

論文

  • Introducing the Amphibious Mudskipper Goby as a Unique Model to Evaluate Neuro/Endocrine Regulation of Behaviors Mediated by Buccal Sensation and Corticosteroids. 国際誌

    Yukitoshi Katayama, Kazuhiro Saito, Tatsuya Sakamoto

    International journal of molecular sciences   21 ( 18 )   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Some fish have acquired the ability to breathe air, but these fish can no longer flush their gills effectively when out of water. Hence, they have developed characteristic means for defense against external stressors, including thirst (osmolarity/ions) and toxicity. Amphibious fish, extant air-breathing fish emerged from water, may serve as models to examine physiological responses to these stressors. Some of these fish, including mudskipper gobies such as Periophthalmodon schlosseri, Boleophthalmus boddarti and our Periophthalmus modestus, display distinct adaptational behaviors to these factors compared with fully aquatic fish. In this review, we introduce the mudskipper goby as a unique model to study the behaviors and the neuro/endocrine mechanisms of behavioral responses to the stressors. Our studies have shown that a local sensation of thirst in the buccal cavity-this being induced by dipsogenic hormones-motivates these fish to move to water through a forebrain response. The corticosteroid system, which is responsive to various stressors, also stimulates migration, possibly via the receptors in the brain. We suggest that such fish are an important model to deepen insights into the stress-related neuro/endocrine-behavioral effects.

    DOI: 10.3390/ijms21186748

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  • Seawater transfer down-regulates C-type natriuretic peptide-3 expression in prolactin-producing cells of Japanese eel: Negative correlation with plasma chloride concentration. 査読 国際誌

    Yukitoshi Katayama, Marty Kwok-Shing Wong, Makoto Kusakabe, Megumi Fujio, Natsuki Takahashi, Miku Yaguchi, Takehiro Tsukada

    Molecular and cellular endocrinology   507   110780 - 110780   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In euryhaline fishes, atrial and B-type natriuretic peptides are important hormones in hypo-osmoregulation, whereas osmoregulatory functions of C-type natriuretic peptides (CNPs) remain to be investigated. Although four CNP isoforms (CNP1-4) are mainly expressed in the brain, multiorgan expression of CNP3 was found in euryhaline Japanese eel, Anguilla japonica. Here we identified the CNP3-expressing cells and examined their response to osmotic stress in eel. CNP3 was expressed in several endocrine cells: prolactin-producing cells (pituitary), glucagon-producing cells (pancreas), and cardiomyocytes (heart). Pituitary CNP3 expression was the highest among organs and was decreased following seawater transfer, followed by a decrease in the freshwater-adaptating (hyper-osmoregulatory) hormone prolactin. We also showed the negative correlation between CNP3/prolactin expression in the pituitary and plasma Cl- concentration, but not for plasma Na+ concentration. These results suggest that CNP3 in the pituitary (and pancreas) plays a critical role in freshwater adaptation of euryhaline eel together with prolactin.

    DOI: 10.1016/j.mce.2020.110780

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  • Hormonal regulation of thirst in the amphibious ray-finned fish suggests the requirement for terrestrialization during evolution. 査読 国際誌

    Yukitoshi Katayama, Yoshio Takei, Makoto Kusakabe, Tatsuya Sakamoto

    Scientific reports   9 ( 1 )   16347 - 16347   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Thirst has evolved for vertebrate terrestrial adaptation. We previously showed that buccal drying induced a series of drinking behaviours (migration to water-taking water into the mouth-swallowing) in the amphibious mudskipper goby, thereby discovering thirst in ray-finned fish. However, roles of dipsogenic/antidipsogenic hormones, which act on the thirst center in terrestrial tetrapods, have remained unclear in the mudskipper thirst. Here we examined the hormonal effects on the mudskipper drinking behaviours, particularly the antagonistic interaction between angiotensin II (AngII) and atrial natriuretic peptide (ANP) which is important for thirst regulation in mammalian 'forebrain'. Expectedly, intracerebroventricular injection of ANP in mudskippers reduced AngII-increased drinking rate. ANP also suppressed the neural activity at the 'hindbrain' region for the swallowing reflex, and the maintenance of buccopharyngeal water due to the swallowing inhibition may attenuate the motivation to move to water. Thus, the hormonal molecules involved in drinking regulation, as well as the influence of buccopharyngeal water, appear to be conserved in distantly related species to solve osmoregulatory problems, whereas hormonal control of thirst at the forebrain might have been acquired only in tetrapod lineage during evolution.

    DOI: 10.1038/s41598-019-52870-7

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  • Drinking by amphibious fish: convergent evolution of thirst mechanisms during vertebrate terrestrialization. 査読 国際誌

    Yukitoshi Katayama, Tatsuya Sakamoto, Kazuhiro Saito, Hirotsugu Tsuchimochi, Hiroyuki Kaiya, Taro Watanabe, James T Pearson, Yoshio Takei

    Scientific reports   8 ( 1 )   625 - 625   2018年1月

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    記述言語:英語  

    Thirst aroused in the forebrain by angiotensin II (AngII) or buccal drying motivates terrestrial vertebrates to search for water, whereas aquatic fish can drink surrounding water only by reflex swallowing generated in the hindbrain. Indeed, AngII induces drinking through the hindbrain even after removal of the whole forebrain in aquatic fish. Here we show that AngII induces thirst also in the amphibious mudskipper goby without direct action on the forebrain, but through buccal drying. Intracerebroventricular injection of AngII motivated mudskippers to move into water and drink as with tetrapods. However, AngII primarily increased immunoreactive c-Fos at the hindbrain swallowing center where AngII receptors were expressed, as in other ray-finned fish, and such direct action on the forebrain was not found. Behavioural analyses showed that loss of buccal water on land by AngII-induced swallowing, by piercing holes in the opercula, or by water-absorptive gel placed in the cavity motivated mudskippers to move to water for refilling. Since sensory detection of water at the bucco-pharyngeal cavity like 'dry mouth' has recently been noted to regulate thirst in mammals, similar mechanisms seem to have evolved in distantly related species in order to solve osmoregulatory problems during terrestrialization.

    DOI: 10.1038/s41598-017-18611-4

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  • The Amphibious Mudskipper: A Unique Model Bridging the Gap of Central Actions of Osmoregulatory Hormones Between Terrestrial and Aquatic Vertebrates. 査読

    Katayama Y, Sakamoto T, Takanami K, Takei Y

    Frontiers in physiology   9   1112   2018年

  • Mudskipper to general behavioral neuroendocrinology 査読

    Tatsuya Sakamoto, Yukitoshi Katayama, Yasuhisa Kobayashi, Kazuhiro Saito, Yoshio Takei

    NIPPON SUISAN GAKKAISHI   81 ( 5 )   868 - 868   2015年9月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPANESE SOC FISHERIES SCIENCE  

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