2022/07/02 更新

写真a

ホンダ ヒロユキ
本多 寛之
HONDA Hiroyuki
所属
岡山大学病院 助教(特任)
職名
助教(特任)
外部リンク

学位

  • 医学博士 ( 2019年12月   岡山大学 )

研究キーワード

  • 糖尿病

研究分野

  • ライフサイエンス / 代謝、内分泌学  / 糖尿病

学歴

  • 岡山大学   Graduate School of Medicine , Dentistry and Pharmaceutical Sciences  

    2015年4月 - 2019年12月

      詳細を見る

  • 岡山大学    

    2004年4月 - 2010年3月

      詳細を見る

経歴

  • 岡山大学病院   総合内科・総合診療科   助教

    2021年4月 - 現在

      詳細を見る

  • 岡山大学医歯薬学総合研究科   瀬戸内(まるがめ)総合診療医学講座   助教

    2020年4月 - 2021年3月

      詳細を見る

  • 岡山市立市民病院   内科・糖尿病センター   医員

    2015年4月 - 2020年3月

      詳細を見る

  • 岡山市立市民病院   後期研修医

    2012年4月 - 2015年3月

      詳細を見る

  • 岡山市立市民病院   初期研修医

    2010年4月 - 2012年3月

      詳細を見る

所属学協会

  • 日本糖尿病医療学学会

    2020年6月 - 現在

      詳細を見る

  • 日本糖尿病・妊娠学会

    2017年10月 - 現在

      詳細を見る

  • 日本糖尿病学会

    2012年12月 - 現在

      詳細を見る

  • 日本内科学会

    2010年11月 - 現在

      詳細を見る

 

論文

  • Impact of the day of the week on the discontinuation of broad-spectrum antibiotic prescriptions; a multi-centered observational study. 国際誌

    Hiroyuki Honda, Hideharu Hagiya, Tsukasa Higashionna, Yuto Haruki, Mai Haruki, Shiho Kajita, Kengo Mukuda, Yuji Yokoyama, Yasuhiro Nakano, Hiroko Ogawa, Yasuyo Morimoto, Yoshihisa Hanayama, Setsuko Kanda, Hitomi Kataoka, Hitomi Muguruma, Fumio Otsuka

    Scientific reports   11 ( 1 )   20784 - 20784   2021年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    To encourage and guide antimicrobial stewardship team (AST) activity and promote appropriate antibiotic use, we studied the impact of day of the week on the initiation and discontinuation of antibiotic administration. This was a multicenter observational study conducted at 8 Japanese hospitals from April 1 to September 30, 2019, targeting patients who underwent treatment with broad-spectrum antibiotics, such as anti-methicillin-resistant Staphylococcus aureus agents and anti-pseudomonal agents. We compared the weekly numbers of initiations and discontinuations of antibiotic prescription on each day of the week or on the days after a holiday. There was no statistical difference in the number of antibiotic initiations on both weekdays and the day after a holiday. However, antibiotic discontinuation was significantly higher from Tuesday onward than Monday and from the second day than the first day after a holiday. Similar trends were observed regardless of the categories of antibiotics, hospital and admission ward, and AST activity. This study suggests that broad-spectrum antibiotics tend to be continued during weekends and holidays and are most likely to be discontinued on Tuesday or the second day after a holiday. This was probably due to behavioral factors beyond medical indications, requiring further antimicrobial stewardship efforts in the future.

    DOI: 10.1038/s41598-021-00206-9

    PubMed

    researchmap

  • Clinical Relevance of Blood Glucose and Gastroesophageal Reflux Symptoms to Depressive Status in Patients with Type 2 Diabetes Mellitus.

    Hiroyuki Honda, Yoshihisa Hanayama, Mikako Obika, Kou Hasegawa, Jun Hamahara, Masayuki Kishida, Hideharu Hagiya, Hiroko Ogawa, Hitomi Kataoka, Fumio Otsuka

    Acta medica Okayama   74 ( 1 )   33 - 40   2020年2月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A relationship between diabetes and depression is apparent. To clarify the clinical relevance of diabetic patients' gastroesophageal symptoms to their psychological status, we retrospectively analyzed the data from a Selfrating Depression Scale (SDS) and a Frequency Scale for Symptoms of Gastroesophageal reflux disease (FSSG) among 143 type 2 diabetic patients who visited a general medicine department. Among the 45 Japanese patients enrolled, the group with relatively high SDS scores (≥ 36) showed higher (FSSG) dysmotility symptom scores versus the low-SDS (< 36) group, although the 2 groups' characteristics and laboratory data were not significantly different. Positive correlations of postprandial plasma glucose (PPG) levels with FSSG scores (R=0.321, p<0.05), particularly with reflux scores (R=0.455, p<0.01) were revealed. PPG and HbA1c levels were not correlated with SDS scores. The patients' SDS scores were significantly correlated with their FSSG scores (R=0.41, p<0.01), suggesting that depressive status is linked to GERD-related manifestations. Considering that the patients' PPG levels were correlated with GERD-related symptoms, diabetic patients' blood glucose levels are associated with depressive status. Collectively, key symptoms related to GERD and glucose level values would be helpful.

    DOI: 10.18926/AMO/57950

    PubMed

    researchmap

  • Relationship between patients’ characteristics and efficacy of calcimimetics for primary hyperparathyroidism in the elderly

    Koichiro Yamamoto, Yasuhiro Nakano, Kazuki Tokumasu, Hiroyuki Honda, Kou Hasegawa, Asuka Sato, Hiroko Ogawa, Mikako Obika, Yoshihisa Hanayama, Fumio Otsuka

    Clinical Case Reports   10 ( 4 )   2022年4月

     詳細を見る

    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1002/ccr3.5713

    researchmap

    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ccr3.5713

  • Hemothorax and Bloody Ascites Caused by Vascular Ehlers-Danlos Syndrome. 国際誌

    Shuichi Tanaka, Hiroyuki Honda, Kou Hasegawa, Koji Tomita, Reimi Sogawa, Hideki Yamamoto, Takao Hiraki, Akira Hirasawa, Fumio Otsuka

    The American journal of medicine   2022年3月

     詳細を見る

  • 肺癌治療中の発熱を契機に発見されたペムブロリズマブによるirAEの1例

    平仲 凪, 山本 紘一郎, 田中 秀一, 孫 麗那, 高橋 美砂, 本多 寛之, 長谷川 功, 大塚 文男

    日本内分泌学会雑誌   97 ( 4 )   951 - 951   2021年12月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

    researchmap

  • GH補充療法により脂肪肝の著明な改善を認めたAGHDの1例

    高瀬 了輔, 中野 靖浩, 山本 紘一郎, 越智 可奈子, 本多 寛之, 長谷川 功, 三好 智子, 小川 弘子, 大塚 文男

    日本内分泌学会雑誌   97 ( 4 )   951 - 951   2021年12月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

    researchmap

  • COVID-19後の倦怠感を契機に発見されたLOH症候群の1例

    副島 佳晃, 中野 靖浩, 中本 健太, 大塚 勇輝, 櫻田 泰江, 徳増 一樹, 本多 寛之, 長谷川 功, 萩谷 英大, 大塚 文男

    日本内分泌学会雑誌   97 ( 4 )   958 - 958   2021年12月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

    researchmap

  • Clinical utility of urinary levels of catecholamines and their fraction ratios related to heart rate and thyroid function.

    Naruhiko Sunada, Yoshihisa Hanayama, Koichiro Yamamoto, Yasuhiro Nakano, Takahiro Nada, Hiroyuki Honda, Kou Hasegawa, Hideharu Hagiya, Fumio Otsuka

    Endocrine journal   2021年11月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Urinary catecholamines (CAs) have been examined for the screening of pheochromocytomas. The decision to perform screening is based on symptoms suggesting secondary hypertension or hyperactivities of the sympathetic nervous system. To elucidate the usefulness of urinary fractions and ratios of CAs, 79 patients in whom 24-h excretions of urinary CAs including adrenaline (AD), noradrenaline (NA) and dopamine (DA) had been examined from 2015 until 2020 were retrospectively analyzed. There were no significant differences in urinary CA levels between two age groups, gender groups and two BMI groups. Patients with histories of preexisting hypertension and diabetes showed significantly higher levels of urinary NA excretion, and the urinary ratio of NA/DA was also increased in the patients with a history of hypertension. Heart rate (HR) was significantly correlated with the urinary ratio of NA/DA. Serum free thyroxine (FT4) concentration and ratio of FT4/thyrotropin (TSH) were correlated with the level of urinary AD. The levels of TSH and FT4/TSH showed negative and positive correlations, respectively, with the urinary NA/DA ratio. Thus, increases of HR are related to the enhanced conversion of DA to NA and increased thyroid hormones are involved in the increase in urinary AD and the conversion of DA to NA. History of lifestyle-related diseases and changes of HR and thyroid functions need to be considered for the evaluation of urinary CAs and their ratios.

    DOI: 10.1507/endocrj.EJ21-0488

    PubMed

    researchmap

  • 【COVID-19-その診断と治療】倦怠感

    大塚 勇輝, 徳増 一樹, 本多 寛之, 萩谷 英大, 大塚 文男

    カレントテラピー   39 ( 11 )   1034 - 1039   2021年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:(株)ライフメディコム  

    新型コロナウイルス感染症(COVID-19)が最初に報告されてからおよそ1年半が経過したが、いまだ収束の兆しの見えない世界的流行のなかで「Long-COVID」ないし「post-acute sequelae of COVID-19(PASC)」と定義され、一般には「コロナ後遺症」として知られる、急性期以降に残存する症状に悩まされる患者が多く存在している。そのなかでも「倦怠感」は、最も多い症状として報告され、COVID-19罹患後に4割程度の患者が自覚すると言われている。倦怠感は視認できず検査での客観的評価も難しい症状である一方で、さまざまな要因が複雑に絡みあって生じており病態メカニズムも未解明なところが多く、診療に難渋する。われわれは2021年2月にLong-COVID/PASCを専門的に診療する「コロナ・アフターケア(COVID-19 aftercare:CAC)外来」を大学病院内にいち早く設立し、倦怠感などの症状に悩む患者の診療と研究・教育に取り組んできた。本稿ではそうしたわれわれの診療経験も踏まえ、診断や治療を行ううえでの対面診療の必要性や総合診療的アプローチの重要性についても触れながら、Long-COVID/PASCにおける倦怠感について概説する。(著者抄録)

    researchmap

  • Calcified spleen associated with Pneumocystis jirovecii infection. 国際誌

    Koichiro Yamamoto, Hiroyuki Honda, Hideharu Hagiya, Fumio Otsuka

    QJM : monthly journal of the Association of Physicians   2021年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/qjmed/hcab260

    PubMed

    researchmap

  • Clinical Characteristics of Japanese Patients Who Visited a COVID-19 Aftercare Clinic for Post-Acute Sequelae of COVID-19/Long COVID. 国際誌

    Yuki Otsuka, Kazuki Tokumasu, Yasuhiro Nakano, Hiroyuki Honda, Yasue Sakurada, Naruhiko Sunada, Daisuke Omura, Kou Hasegawa, Hideharu Hagiya, Mikako Obika, Keigo Ueda, Hitomi Kataoka, Fumio Otsuka

    Cureus   13 ( 10 )   e18568   2021年10月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Introduction The long-term clinical course, prognosis, and optimal management of symptoms and conditions after the acute phase of coronavirus disease 2019 (COVID-19) remain to be elucidated. The purpose of this study was to clarify the characteristics of patients referred to a COVID-19 aftercare (CAC) clinic established at a tertiary academic hospital in Japan. Methods This study was a descriptive case series study. All patients who visited the CAC clinic between February 15 and September 17 in 2021 were included. Patients' background, chief complaints, and clinical courses after the onset of COVID-19 were described. Results A total of 87 Japanese patients (median age, 40.0 years; interquartile range [IQR], 26.5-53.0 years; 52.9% women) were referred to the CAC clinic. The median interval between the onset of COVID-19 and the visit to the clinic was 79.0 (IQR, 52.5-112.0) days. Referral sources were hospitals (36 patients), clinics (47 patients), a local healthcare center (3 patients), and other (1 patient). The most common chief complaint was general fatigue (50.4%) followed by dysosmia (28.7%), dysgeusia (26.4%), hair loss (18.4%), headache (17.2%), dyspnea (16.1%), and dyssomnia (13.1%). Respiratory symptoms were common in the early stages of the disease but were less common as the chief complaints when visiting the clinic. On the other hand, neurological, psychiatric, and extremity symptoms were predominant one month after the onset of COVID-19. Conclusions Regardless of the severity in the acute phase, patients visiting our CAC clinic suffered from a variety of symptoms. General physicians skilled in using a comprehensive approach would be optimal to see patients with such complex symptoms.

    DOI: 10.7759/cureus.18568

    PubMed

    researchmap

  • COVID-19肺炎を発症した高Ca血症・肺病変を伴うMEN1の1例

    大塚 勇輝, 田中 秀一, 本多 寛之, 長谷川 功, 萩谷 英大, 小松原 基志, 岸田 雅之, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   548 - 548   2021年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

    researchmap

  • COVID-19後の後遺症が診断の契機となったLOH症候群の1例

    副島 佳晃, 中野 靖浩, 徳増 一樹, 大塚 勇輝, 櫻田 泰江, 本多 寛之, 中本 健太, 長谷川 功, 萩谷 英大, 植田 圭吾, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   496 - 496   2021年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

    researchmap

  • 心不全・肝不全から発見された高齢橋本病の1例

    上枝 礼佳, 山本 紘一郎, 田中 秀一, 孫 麗那, 本多 寛之, 長谷川 功, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   516 - 516   2021年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

    researchmap

  • 不明熱精査からirAEによるACTH単独欠損症と診断した2例

    平仲 凪, 山本 紘一郎, 田中 秀一, 孫 麗那, 高橋 美砂, 本多 寛之, 長谷川 功, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   488 - 488   2021年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

    researchmap

  • 虹彩炎が治療導入の契機となった2型糖尿病の1例

    中本 健太, 本多 寛之, 平 佑貴, 庵谷 紘美, 中野 靖浩, 長谷川 功, 萩谷 英大, 小比賀 美香子, 片岡 仁美, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   555 - 555   2021年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

    researchmap

  • 虹彩炎が治療導入の契機となった2型糖尿病の1例

    中本 健太, 本多 寛之, 平 佑貴, 庵谷 紘美, 中野 靖浩, 長谷川 功, 萩谷 英大, 小比賀 美香子, 片岡 仁美, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   555 - 555   2021年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

    researchmap

  • COVID-19後の後遺症が診断の契機となったLOH症候群の1例

    副島 佳晃, 中野 靖浩, 徳増 一樹, 大塚 勇輝, 櫻田 泰江, 本多 寛之, 中本 健太, 長谷川 功, 萩谷 英大, 植田 圭吾, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   496 - 496   2021年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

    researchmap

  • 不明熱精査からirAEによるACTH単独欠損症と診断した2例

    平仲 凪, 山本 紘一郎, 田中 秀一, 孫 麗那, 高橋 美砂, 本多 寛之, 長谷川 功, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   488 - 488   2021年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

    researchmap

  • COVID-19肺炎を発症した高Ca血症・肺病変を伴うMEN1の1例

    大塚 勇輝, 田中 秀一, 本多 寛之, 長谷川 功, 萩谷 英大, 小松原 基志, 岸田 雅之, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   548 - 548   2021年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

    researchmap

  • 心不全・肝不全から発見された高齢橋本病の1例

    上枝 礼佳, 山本 紘一郎, 田中 秀一, 孫 麗那, 本多 寛之, 長谷川 功, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   516 - 516   2021年10月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

    researchmap

  • Triad signs shown by bone scintigraphy in FGF23-related osteomalacia. 国際誌

    Koichiro Yamamoto, Hiroyuki Honda, Itsuro Ota, Fumio Otsuka

    QJM : monthly journal of the Association of Physicians   2021年9月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/qjmed/hcab240

    PubMed

    researchmap

  • Leriche syndrome. 国際誌

    Hiroki Matsuura, Hiroyuki Honda

    Cleveland Clinic journal of medicine   88 ( 9 )   482 - 483   2021年9月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3949/ccjm.88a.20179

    PubMed

    researchmap

  • Gender-Dependent Characteristics of Serum 1,25-Dihydroxyvitamin D/25-Hydroxyvitamin D Ratio for the Assessment of Bone Metabolism. 国際誌

    Manami Fujita-Yamashita, Koichiro Yamamoto, Hiroyuki Honda, Yoshihisa Hanayama, Kazuki Tokumasu, Yasuhiro Nakano, Kou Hasegawa, Hideharu Hagiya, Mikako Obika, Hiroko Ogawa, Fumio Otsuka

    Cureus   13 ( 9 )   e18070   2021年9月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Objectives Vitamin D deficiency, which is common worldwide, increases the risks of falls and fractures and can lead to increased morbidity and mortality. However, the clinical utility and relevance of vitamin D activation remain unknown. The aim of the present study was to clarify the clinical usefulness of serum 1,25-dihydroxyvitamin D (1,25D)/25-hydroxyvitamin D (25D) ratio for assessment of the extent of bone metabolism. Methods We retrospectively screened data for 87 patients whose serum 1,25D and 25D levels were measured. Eight patients who were taking vitamin D preparations were excluded, and data for 79 patients (33 males and 46 females) were analyzed. Since menopausal status can be associated with serum vitamin D level, we divided the patients by gender and divided the female patients into two groups at the age of 50 years. Results The median serum 1,25D/25D ratio was significantly lower in males than in females, with the most considerable difference in all males [4.1 (interquartile range: 2.3-5.8) × 10-3] versus elderly females (aged ≧50 years) [7.9 (3.3-10.1) × 10-3). Main disorders were endocrine (30.6%), inflammatory (18.5%), and bone-related (16.7%) disorders. The ratios of serum 1,25D/25D had significant negative correlations with femoral dual-energy X-ray absorptiometry % young adult mean (DEXA %YAM) (R=-0.35) and lumbar DEXA %YAM (R=-0.32). Significant correlations were found between the 1,25D/25D ratio and serum levels of inorganic phosphate (iP), parathyroid hormone, and alkaline phosphatase (ALP). The 1,25D/25D ratio had gender-specific characteristics: the ratio was significantly correlated with age in males (R=-0.49), while it was significantly correlated with BMI in females (R=0.34). Conclusions The results of this study suggested that vitamin D activity is negatively correlated with bone mineral density, being reduced in aged males but enhanced in obese females.

    DOI: 10.7759/cureus.18070

    PubMed

    researchmap

  • Acute pancreatitis without abdominal pain induced by administration of nivolumab and ipilimumab. 国際誌

    Koichiro Yamamoto, Kosuke Oka, Reina Son, Hiroyuki Honda, Hiroyuki Sakae, Kou Hasegawa, Shigeru Horiguchi, Hironari Kato, Osamu Yamasaki, Fumio Otsuka

    Modern rheumatology case reports   5 ( 2 )   425 - 430   2021年7月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Immune checkpoint inhibitors (ICIs) such as nivolumab and ipilimumab are emerging agents for the treatment of cancers including melanoma. ICIs are known to cause immune-related adverse events (irAEs), including the development of enterocolitis, dermatitis, and nephritis. However, ICI-induced pancreatitis has seldom been reported, and its pathophysiology and clinical importance remain largely unknown. We describe a 76-year-old man with melanoma who developed acute pancreatitis without abdominal pain after immunotherapy with nivolumab and ipilimumab. The patient was referred due to 2-week-long general fatigue, anorexia, and dermatitis after his second immunotherapy. Laboratory examinations in serum showed high inflammation and renal dysfunction. Plain computed tomography (CT) on admission showed no new lesions including colitis or pancreatitis. On the 4th day of hospitalisation, serum pancreatic enzymes were extremely elevated. Amylase was increased to 683 U/L (normal range: 44-132) and lipase was increased to 1520 U/L (13-55), but he had no abdominal tenderness. Contrast-enhanced CT showed enlarged pancreatic parenchyma and magnetic resonance cholangiopancreatography showed peripancreatic fat stranding, suggesting pancreatitis. Blood culture tests and empirical antibiotic therapy with ceftriaxone indicated no active infectious diseases. We diagnosed ICI-induced pancreatitis and treated him with 0.5 mg/kg/day of prednisolone, which improved his general fatigue, anorexia, dermatitis, and pancreatitis. The potential significance of asymptomatic elevations of pancreatic enzymes has been unclear; however, this case suggested that ICI-induced pancreatitis without abdominal tenderness could be clinically significant. Clinicians should pay attention to the development of latent pancreatitis in patients receiving ICIs, even those without abdominal pain.

    DOI: 10.1080/24725625.2021.1899444

    PubMed

    researchmap

  • Clinical Utility of the Ratio of Urinary Free Cortisol to Aldosterone as an Index for Inflammatory and Metabolic Dysregulation. 国際誌

    Yuki Otsuka, Yasuhiro Nakano, Kazuki Tokumasu, Hiroyuki Honda, Mikako Obika, Kou Hasegawa, Yoshihisa Hanayama, Koichi Itoshima, Fumio Otsuka

    Annals of clinical and laboratory science   51 ( 3 )   352 - 358   2021年5月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    OBJECTIVE: Urinary free cortisol (UFC) is a reliable marker to avoid cortisol fluctuation and the effects of binding proteins. However, UFC levels are affected by fluid intake and urine volume, and the normal levels range widely. METHODS: To discover the utility of the ratio of urinary cortisol to aldosterone excretions, 246 patients in whom daily excretions of UFC and aldosterone (UAC) were measured were retrospectively analyzed. RESULTS: The UFC/UAC ratio showed significant positive and negative correlations with the levels of serum cortisol (R=0.287) and aldosterone (R=-0.762), respectively. The UFC/UAC ratio increased with aging in female patients, while it was not altered by the level of BMI in either gender. Markers for metabolic and inflammatory status, including hemoglobin A1c (R=0.327), albumin (R=-0.331), C-reactive protein (R=0.317), ferritin (R=0.473), and D-dimer (R=0.569), showed correlations with the ratio of UFC/UAC that were more significant than the correlations with the serum level of cortisol or UFC alone. Of note, the UFC/UAC ratio was shown to be an indicator for the risk of diabetes (AUC: 0.765), hypoalbuminemia (0.839), hyper-CRPemia (0.748), and thrombophilia (0.824), in which the cut-off levels of the UFC/UAC ratio were around 12. CONCLUSION: The UFC/UAC ratio is a variable for detecting metabolic and inflammatory complications related to adrenocortical dysfunction.

    PubMed

    researchmap

  • Pseudoacromegaly with acromegalic features in radiography. 国際誌

    Koichiro Yamamoto, Kosuke Oka, Hiroyuki Honda, Kou Hasegawa, Fumio Otsuka

    Clinical case reports   9 ( 5 )   e04095   2021年5月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Pseudoacromegaly is a condition characterized by acromegalic physical features without growth hormone excess, for which radiographic observation has seldom been reported. This is a rare case of pseudoacromegaly.

    DOI: 10.1002/ccr3.4095

    PubMed

    researchmap

  • An adrenal incidentaloma caused by synchronous and isolated metastasis. 国際誌

    Koichiro Yamamoto, Kosuke Oka, Hiroyuki Honda, Kou Hasegawa, Yoshihisa Hanayama, Tomofumi Watanabe, Yusuke Tominaga, Atsushi Takamoto, Takayuki Hara, Fumio Otsuka

    Clinical case reports   9 ( 4 )   2494 - 2495   2021年4月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    We report a patient with adrenal incidentaloma due to synchronous and isolated metastasis from lung cancer, which is a relatively rare condition. Close checkups for incidentaloma in oncologic patients are mandatory, leading to successful operation.

    DOI: 10.1002/ccr3.3996

    PubMed

    researchmap

  • 性腺機能低下を伴いコロナ禍で高度肥満を呈した成人21-水酸化酵素欠損症の1例

    山本 紘一郎, 岡 浩介, 長谷川 功, 越智 可奈子, 中野 靖浩, 徳増 一樹, 本多 寛之, 小比賀 美香子, 大塚 文男

    日本内分泌学会雑誌   96 ( 4 )   1041 - 1041   2021年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

    researchmap

  • 尿中遊離コルチゾール/アルドステロン比と代謝・炎症マーカーとの関連性

    大塚 勇輝, 中野 靖浩, 徳増 一樹, 本多 寛之, 大村 大輔, 花山 宜久, 長谷川 功, 小比賀 美香子, 小川 弘子, 大塚 文男

    日本内分泌学会雑誌   96 ( 4 )   1044 - 1044   2021年4月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

    researchmap

  • Clinical Characteristics of Low Androgen Status in Males with Type 2 Diabetes Mellitus.

    Jun Hamahara, Hiroyuki Honda, Koichiro Yamamoto, Kazuki Tokumasu, Yoshihisa Hanayama, Hideharu Hagiya, Mikako Obika, Keigo Ueda, Masayuki Kishida, Fumio Otsuka

    Acta medica Okayama   75 ( 1 )   1 - 8   2021年2月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    To determine the clinical characteristics of low androgen status in adult males with diabetes, we retrospectively analyzed the medical records of patients with type 2 diabetes mellitus in whom serum free testosterone (FT) levels were examined for 1 year. Among the 46 patients (56 ± 1.5 years old), decreases in serum FT levels to < 8.5 pg/ml (indicating the occurrence of late-onset hypogonadism [LOH]) were detected in 18 (39%). The per-centages of patients with low FT levels were high in the ≥ 50 years age group (83%), the HbA1c < 7% group (67%), and the 25 ≤ BMI < 30 kg/m2 group (56%). The serum FT levels tended to decrease age-dependently. The level of HbA1c was significantly correlated with the Heinemann Aging Male Symptoms (AMS) score (R = 0.47). The low-FT group had decreased levels of hemoglobin. Of note, the serum FSH level (R = -0.32) was negatively correlated with the serum FT level, whereas the serum TSH level (R = 0.36) was positively correlated with the serum FT level. Collectively, these results revealed that many diabetic males may have low FT levels and that the AMS score is related to the HbA1c level. A slightly anemic condition, thyroid dysfunction, and obesity (class 1) might be involved in LOH in middle-aged diabetic males.

    DOI: 10.18926/AMO/61424

    PubMed

    researchmap

  • Clinical Manifestations of Patients with Influenza Differ by Age : A Prospective, Multi-centered Study in the Setouchi Marine Area.

    Ryosuke Takase, Hideharu Hagiya, Hiroyuki Honda, Yasuhiro Nakano, Hiroko Ogawa, Mikako Obika, Keigo Ueda, Hitomi Kataoka, Yoshihisa Hanayama, Fumio Otsuka

    Acta medica Okayama   75 ( 5 )   567 - 574   2021年

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Influenza potentially has a high mortality rate when it affects the elderly. We aimed to examine the differences in clinical manifestations in patients with influenza according to their age. This multicenter prospective study was performed in six medical institutions in Okayama and Kagawa prefectures (Japan). Between December 1, 2019 and March 31, 2020, we collected data on adult patients diagnosed with influenza type A, who were strat-ified into younger (20-49 years), middle-aged (50-64 years), and older groups (≥ 65 years). We compared the presence or absence of fever, respiratory symptoms, and extrapulmonary symptoms according to age group. In total, 203 patients (113, younger; 51, middle-aged; and 39, older) were eligible for the analysis. The maxi-mum body temperature and temperature at first physician visit in the older group were significantly lower than those in the younger group. The incidence of respiratory symptoms was not different among the three groups. Chills, muscle pain, and arthralgia as systemic symptoms were noted significantly more frequently in the younger (80.9%) and middle-aged (75.5%) groups than in the older group (51.3%) (p = 0.002). Fever and sys-temic symptoms were less likely to appear in older patients, possibly resulting in the delaying of hospital visits among older adults.

    DOI: 10.18926/AMO/62769

    PubMed

    researchmap

  • Recurrence of Hypoglycemic Coma in a Patient with Anorexia Nervosa.

    Koichiro Yamamoto, Daisuke Omura, Mai Yamane, Reina Son, Kou Hasegawa, Hiroyuki Honda, Mikako Obika, Nozomu Minao, Satoru Edahiro, Norihito Yamada, Fumio Otsuka

    Acta medica Okayama   75 ( 5 )   631 - 636   2021年

     詳細を見る

    記述言語:英語  

    Anorexia nervosa (AN) is occasionally complicated with hypoglycemic coma, which may cause sudden death by unknown mechanisms. We present the case of a 36-year-old woman with recurrent comas and a nineteen-year history of AN. She was found in a coma with remarkable hypoglycemia (28 mg/dL). Her BMI was 11.1 kg/m2. Endocrine workup revealed extremely low serum levels of glucagon, IGF-I and insulin. Asymptomatic hypoglycemia occurred with liver injury in the refeeding process. An aberrant glucose metabolism due to liver damage might have been involved in her susceptibility to hypoglycemia. This case suggests a possible mechanism of hypoglycemic coma in AN.

    DOI: 10.18926/AMO/62776

    PubMed

    researchmap

  • Antimicrobial prescription practices for outpatients with acute respiratory tract infections: A retrospective, multicenter, medical record-based study. 国際誌

    Tomoharu Ishida, Hideharu Hagiya, Hiroyuki Honda, Yasuhiro Nakano, Hiroko Ogawa, Mikako Obika, Keigo Ueda, Hitomi Kataoka, Yoshihisa Hanayama, Fumio Otsuka

    PloS one   16 ( 11 )   e0259633   2021年

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Antimicrobial stewardship for outpatients with acute respiratory tract infections (ARTIs) should be urgently promoted in this era of antimicrobial resistance. Previous large-sample studies were based on administrative data and had limited reliability. We aimed to identify current antimicrobial prescription practices for ARTIs by directly basing on medical records. This multicenter retrospective study was performed from January to December in 2018, at five medical institutes in Japan. We targeted outpatients aged ≥18 years whose medical records revealed International Classification of Diseases (ICD-10) codes suggesting ARTIs. We divided the eligible cases into three age groups (18-64 years, 65-74 years, and ≥75 years). We defined broad-spectrum antimicrobials as third-generation cephalosporins, macrolides, fluoroquinolones, and faropenem. Primary and secondary outcomes were defined as the proportion of antimicrobial prescriptions for the common cold and other respiratory tract infections, respectively. Totally, data of 3,940 patients were collected. Of 2,914 patients with the common cold, 369 (12.7%) were prescribed antimicrobials. Overall, compared to patients aged ≥75 years (8.5%), those aged 18-64 years (16.6%) and those aged 65-74 years (12.1%) were frequently prescribed antimicrobials for the common cold (odds ratio [95% confidential interval]; 2.15 [1.64-2.82] and 1.49 [1.06-2.09], respectively). However, when limited to cases with a valid diagnosis of the common cold by incorporating clinical data, no statistical difference was observed among the age groups. Broad-spectrum antimicrobials accounted for 90.2% of the antimicrobials used for the common cold. Of 1,026 patients with other respiratory infections, 1,018 (99.2%) were bronchitis, of which antimicrobials were prescribed in 49.9% of the cases. Broad-spectrum antimicrobials were the main agents prescribed, accounting for nearly 90% of prescriptions in all age groups. Our data suggested a favorable practice of antimicrobial prescription for outpatients with ARTIs in terms of prescribing proportions, or quantitative aspect. However, the prescriptions were biased towards broad-spectrum antimicrobials, highlighting the need for further antimicrobial stewardship in the outpatient setting from a qualitative perspective.

    DOI: 10.1371/journal.pone.0259633

    PubMed

    researchmap

  • Acute encephalopathy associated with severe fever with thrombocytopaenia syndrome. 国際誌

    Manami Fujita, Yasuhiro Nakano, Hiroyuki Honda, Hideharu Hagiya

    BMJ case reports   13 ( 12 )   2020年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/bcr-2020-240075

    PubMed

    researchmap

  • Severe Visceral Obesity, Fatty Liver and Diabetes after Orchiectomy for Prostate Cancer.

    Nobuo Kajitani, Junko Takahashi, Hiroyuki Honda, Jun Hamahara, Shinichiro Ando

    Internal medicine (Tokyo, Japan)   59 ( 18 )   2281 - 2285   2020年9月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A 79-year-old man without a history of diabetes underwent orchiectomy for prostate cancer. Eight months after the operation, he suffered severe deterioration of visceral fat deposition, fatty liver and diabetes. Treatment for diabetes with canagliflozin and dulaglutide resulted in improvement in his glycemic control, visceral fat and fatty liver. Visceral fat-dominant deposition, which differs from the typical course after androgen deprivation therapy, may have been associated with severe exacerbation of diabetes and fatty liver. Glycemic management with a sodium glucose cotransporter 2 (SGLT2) inhibitor and glucagon-like peptide (GLP)-1 receptor agonist may help improve the glucose metabolism, visceral fat deposition and fatty liver after orchiectomy.

    DOI: 10.2169/internalmedicine.4653-20

    PubMed

    researchmap

  • 内科初診外来におけるSDSとFSSGスコアの有用性と相関性の検討

    菅波 由有, 岡 浩介, 花山 宜久, 浜原 潤, 小比賀 美香子, 本多 寛之, 狩山 和也, 岸田 雅之, 大塚 文男

    日本内科学会雑誌   109 ( Suppl. )   230 - 230   2020年2月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本内科学会  

    researchmap

  • Correlations between Depressive Condition and Gastroesophageal Reflux Symptoms in Patients Visiting a Department of General Medicine.

    Yu Suganami, Kosuke Oka, Yoshihisa Hanayama, Hiroyuki Honda, Jun Hamahara, Mikako Obika, Kazuya Kariyama, Masayuki Kishida, Fumio Otsuka

    Acta medica Okayama   73 ( 6 )   479 - 486   2019年12月

     詳細を見る

    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    To clarify the potential relevance of patients' chief complaints at a general medicine department to their self-rating depression scale (SDS) and frequency scale for symptoms of gastroesophageal reflux disease (GERD) (FSSG) scores, we analyzed data of 478 patients who visited our general medicine department. The chief complaints (553 symptoms of 447 patients) were categorized into major symptom-based groups: respiratory (31%), circulatory (3%), gastrointestinal (GI) tract (26%), neurology (8%), orthopedic and skin (10%), and systemic (22%) symptoms. The SDS score tended to be higher in females and younger patients. The FSSG score did not differ by gender but was higher in younger patients. The patients receiving social welfare had higher SDS and FSSG scores. A close inter-relationship between the FSSG (including both degrees of reflux and dysmotility) and SDS was observed in all patients. Although the averages of the SDS and FSSG scores were not significantly different among the symptom-based categories, we observed significantly positive correlations between the FSSG and SDS in each category, suggesting that depressive status may be closely related to GERD-related symptoms regardless of the patients' chief complaints. An initial checkup of patients' psychological condition and/or GERD-like symptoms could help screen for latent disorders in outpatients with uncertain complaints.

    DOI: 10.18926/AMO/57711

    PubMed

    researchmap

  • 総合内科外来におけるうつ状態とGERD症状の相関関係について

    菅波 由有, 岡 浩介, 花山 宜久, 浜原 潤, 小比賀 美香子, 本多 寛之, 狩山 和也, 岸田 雅之, 大塚 文男

    日本病院総合診療医学会雑誌   15 ( 6 )   615 - 615   2019年11月

     詳細を見る

    記述言語:日本語   出版者・発行元:(一社)日本病院総合診療医学会  

    researchmap

▼全件表示

書籍等出版物

  • 総合内科I II III・消化器・循環器・内分泌・代謝・腎臓

    筒泉 貴彦, 山田 悠史( 担当: 分担執筆)

    医学書院  2021年4月  ( ISBN:9784260043335

     詳細を見る

    総ページ数:ix, 405p   記述言語:日本語

    CiNii Books

    researchmap

  • General Mindで攻める総合内科で診る内分泌疾患

    大塚, 文男( 担当: 分担執筆 ,  範囲: CHAPTER 3 - 18 肥満への教育・治療介入)

    中外医学社  2020年4月  ( ISBN:9784498020849

     詳細を見る

    総ページ数:iv,369p   記述言語:日本語

    CiNii Books

    researchmap

MISC

  • 新型コロナウイルス感染症対策における慰労金交付事業の影響およびその評価 査読

    萩谷英大, 三好智子, 西村義人, 徳増一樹, 本多寛之, 長谷川功, 小比賀美香子, 頼藤貴志, 大塚文男

    日本病院総合診療医学会雑誌   17 ( 6 )   608 - 616   2021年11月

     詳細を見る

  • 倦怠感

    大塚勇輝, 徳増一樹, 本多寛之, 萩谷英大, 大塚文男

    月間カレントテラピー   39 ( 11 )   18 - 23   2021年11月

     詳細を見る

  • 免疫グロブリン製剤の投与後に一過性の抗GAD抗体陽性を示した2型糖尿病の2例 査読

    高橋 順子, 本多 寛之, 浜原 潤, 梶谷 展生, 安藤 晋一郎, 出口 章子, 出口 健太郎

    糖尿病   63 ( 11 )   770 - 775   2020年11月

     詳細を見る

  • 2型糖尿病患者における随時血糖・胃食道逆流症状が及ぼす心理状態への影響

    本多寛之, 小比賀美香子, 花山宜久, 岸田雅之, 安田美帆, 長谷川功, 片岡仁美, 大塚文男

    糖尿病(Web)   63 ( 9 )   2020年

     詳細を見る

  • Basic Outcome Masterに沿った糖尿病教育入院クリニカルパスのバリアンス分析と改善の取り組み 査読

    高橋 順子, 本多 寛之, 浜原 潤, 寺見 隆宏, 安藤 晋一郎, 赤沢 友里恵, 安永 沙織, 杉山 直也, 黒住 友郁, 石井 和史

    日本クリニカルパス学会誌   20 ( 4 )   2018年4月

     詳細を見る

講演・口頭発表等

  • インスリン自己注射手技のチェックリストが有用であった高齢1型糖尿病の1例

    本多 寛之

    第64回 日本糖尿病学会年次学術集会  2021年5月22日 

     詳細を見る

    開催年月日: 2021年5月20日 - 2021年5月22日

    会議種別:口頭発表(一般)  

    researchmap

  • 虹彩炎が治療導入の契機となった2型糖尿病の1例

    中本健太, 本多寛之, 平佑貴, 庵谷紘美, 中野靖浩, 長谷川功, 萩谷英大, 小比賀美香子, 片岡仁美, 大塚文男

    第31回臨床内分泌代謝update  2021年11月26日 

     詳細を見る

    開催年月日: 2021年11月26日 - 2021年11月27日

    会議種別:ポスター発表  

    researchmap

  • 胸鎖関節炎・頸部膿瘍を契機に診断した2型糖尿病の1例

    中本健太, 本多寛之, 平佑貴, 庵谷紘美, 中野靖浩, 長谷川功, 萩谷英大, 小比賀美香子, 片岡仁美, 大塚文男

    日本糖尿病学会 中国四国地方会 第59回総会  2021年10月23日 

     詳細を見る

    開催年月日: 2021年10月22日 - 2021年10月23日

    会議種別:口頭発表(一般)  

    researchmap

  • 維持透析中の2型糖尿病患者に発症したフルニエ壊疽の1例

    庵谷紘美, 本多寛之, 平佑貴, 中本健太, 中野靖浩, 長谷川功, 萩谷英大, 小比賀美香子, 片岡仁美, 大塚文男

    日本糖尿病学会 中国四国地方会 第59回総会  2021年10月23日 

     詳細を見る

    開催年月日: 2021年10月22日 - 2021年10月23日

    会議種別:口頭発表(一般)  

    researchmap

  • COVID-19後の倦怠感を契機に発見されたLOH症候群の1例

    副島 佳晃, 中野 靖浩, 中本 健太, 大塚 勇輝, 櫻田 泰江, 徳増 一樹, 本多 寛之, 長谷川 功, 萩谷 英大, 大塚 文男

    第22回日本内分泌学会中国支部学術集会  2021年9月4日 

     詳細を見る

    開催年月日: 2021年9月4日

    会議種別:口頭発表(一般)  

    researchmap

  • GH補充療法により脂肪肝の著明な改善を認めたAGHDの1例

    高瀬 了輔, 中野 靖浩, 山本 紘一郎, 越智 可奈子, 本多 寛之, 長谷川 功, 三好 智子, 小川 弘子, 大塚 文男

    第22回日本内分泌学会中国支部学術集会  2021年9月4日 

     詳細を見る

    開催年月日: 2021年9月4日

    会議種別:口頭発表(一般)  

    researchmap

  • 肺癌治療中の発熱を契機に発見されたペムブロリズマブによるirAEの1 例

    平仲 凪, 山本 紘一郎, 田中 秀一, 孫 麗那, 高橋 美砂, 本多 寛之, 長谷川 功, 大塚 文男

    第22回日本内分泌学会中国支部学術集会  2021年9月4日 

     詳細を見る

    開催年月日: 2021年9月4日

    会議種別:口頭発表(一般)  

    researchmap

▼全件表示

Works(作品等)

  • 岡山大学病院ドクターカー外装デザイン

    本多寛之, Face活性化ミーティング

    2021年8月31日
    -
    現在

     詳細を見る

  • 岡山大学病院案内表紙デザイン

    本多寛之, Face活性化ミーティング

    2021年4月
    -
    2022年3月

     詳細を見る

  • 岡山大学病院総合トリアージステーション(GTS)ロゴデザイン

    本多寛之

    2020年10月
    -
    現在

     詳細を見る

  • 東京モノレール車内ステッカー広告デザイン

    本多寛之, Face活性化ミーティング

    2020年10月
    -
    2021年10月

     詳細を見る

  • 新型コロナウイルス感染対策院内ポスター

    本多寛之, Face活性化ミーティング

    2020年
    -
    現在

     詳細を見る

受賞

  • 楷の木賞

    2020年12月   岡山大学病院  

    "Face"活性化ミーティング

     詳細を見る

 

メディア報道

  • 岡山大学病院 ドクターカー 車体外観デザイン 新聞・雑誌

    毎日新聞  企画特集 「岡山の医療」〜歴史ある医療と教育、そして将来ビジョン〜  2021年12月10日

     詳細を見る