研究者詳細 - 吉田　沙織

論文 - 吉田　沙織

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Central dentinogenic ghost cell tumor of the maxilla: a case report with new imaging findings and review of the literature 査読

Suzuka Yoshida, Yohei Takeshita, Toshiyuki Kawazu, Miki Hisatomi, Shunsuke Okada, Mamiko Fujikura, Kyoichi Obata, Kiyofumi Takabatake, Saori Yoshida, Junichi Asaumi

Oral Radiology 2024年7月

掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

Abstract

A dentinogenic ghost cell tumor (DGCT) is a rare benign odontogenic tumor that commonly shows characteristics of solid proliferation and has a relatively high risk of recurrence after surgical treatment. We herein report a case of a central DGCT that occurred in the maxilla and resulted in bone expansion. This study highlights new imaging findings (particularly magnetic resonance imaging) along with histopathological observations. In addition, we conducted a review of the existing literature on this rare tumor. A 37-year-old man developed swelling around the right cheek. A benign odontogenic tumor such as ameloblastoma was suspected based on the imaging examination findings (including bone expansion and the internal characteristics of the tumor) on panoramic imaging, computed tomography, and magnetic resonance imaging. The lesion was surgically excised from the right maxilla. Postoperative histopathological examination led to a definitive diagnosis of central DGCT. The tumor comprised epithelial neoplastic islands, resembling ameloblastoma, inside tight fibroconnective tissue; masses of ghost cells and formation of dentin were also observed. We had suspected that the minute high-density region around the molars on the imaging examinations represented alveolar bone change; however, it represented dentin formation. This led to difficulty diagnosing the lesion. Although DGCT may present characteristic findings on imaging examinations, its occurrence is infrequent, and in some cases, the findings may include the presence or absence of an impacted tooth without obvious calcification. The present case suggests that we should consider the possibility of an odontogenic tumor with calcification when high-density structures are observed inside the lesion.

DOI： 10.1007/s11282-024-00764-4

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その他リンク： https://link.springer.com/article/10.1007/s11282-024-00764-4/fulltext.html

Efficacy of Cisplatin–CXCR4 Antagonist Combination Therapy in Oral Cancer 査読

Saori Yoshida, Hotaka Kawai, Yamin Soe, Htoo Shwe Eain, Sho Sanou, Kiyofumi Takabatake, Yohei Takeshita, Miki Hisatomi, Hitoshi Nagatsuka, Junichi Asaumi, Yoshinobu Yanagi

Cancers 16 ( 13 ) 2326 - 2326 2024年6月

担当区分：筆頭著者掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

Cisplatin is a platinum-based compound that is widely used for treating inoperable oral squamous cell carcinoma (OSCC) in Japan; however, resistance to cisplatin presents a challenge and innovative approaches are required. We aimed to investigate the therapeutic potential of targeting the chemokine receptor CXCR4, which is involved in angiogenesis and tumor progression, using the CXCR4 inhibitor AMD3100, in combination with cisplatin. AMD3100 induced necrosis and bleeding in OSCC xenografts by inhibiting angiogenesis. We investigated the combined ability of AMD3100 plus cisplatin to enhance the antitumor effect in cisplatin-resistant OSCC. An MTS assay identified HSC-2 cells as cisplatin-resistant cells in vitro. Mice treated with the cisplatin-AMD combination exhibited the most significant reduction in tumor volume, accompanied by extensive hemorrhage and necrosis. Histological examination indicated thin and short tumor vessels in the AMD and cisplatin–AMD groups. These results indicated that cisplatin and AMD3100 had synergistic antitumor effects, highlighting their potential for vascular therapy of refractory OSCC. Antitumor vascular therapy using cisplatin combined with a CXCR4 inhibitor provides a novel strategy for addressing cisplatin-resistant OSCC.

DOI： 10.3390/cancers16132326

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分化度が異なるOSCCにおけるCXCR4阻害剤の有用性

吉田沙織, 河合穂高, 竹下洋平, 岡田俊輔, 藤倉満美子, 久富美紀, 河津俊幸, 長塚仁, 浅海淳一, 柳文修

日本病理学会会誌 112 ( 1 ) 290 - 290 2023年3月

分化度の異なる口腔扁平上皮癌におけるシスプラチンとCXCR4阻害剤併用の効果

吉田沙織, 河合穂高, 竹下洋平, 岡田俊輔, 藤倉満美子, 久富美紀, 河津俊幸, 長塚仁, 浅海淳一, 柳文修

日本口腔診断学会雑誌 36 ( 1 ) 82 - 82 2023年2月

Prediction Formula for Pathological Depth of Invasion From Clinical Depth of Invasion in Tongue Squamous Cell Carcinoma (SCC) Stage I/II Cases. 査読国際誌

Mei Hamada, Yasuhiro Ebihara, Saori Yoshida, Naoko Saito, Yuichro Enoki, Hitoshi Inoue, Satoko Matsumura, Mitsuhiko Nakahira, Masanori Yasuda, Masashi Sugasawa

Cureus 15 ( 2 ) e34516 2023年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The depth of invasion (DOI) of tongue squamous cell carcinoma (SCC) is an important prognostic factor. The definition is clear for pathological DOI (pDOI), but the treatment strategy is determined by the preoperative clinical DOI (cDOI). Few studies have investigated the difference between these DOIs. The purpose of this study was to obtain the correlation equation between cDOI and pDOI for Stage I/II tongue SCC and to consider the points to be noted in actual clinical practice. METHODS: In this retrospective study, 58 patients with clinical stage I/II tongue SCC were included. Correlations between cDOI and pDOI were obtained for all 58 cases, as well as for 39 cases which excluded superficial and exophytic lesions. RESULTS: The overall cDOI and pDOI median values were 8.0 and 5.5 mm, respectively; the 2.5 mm reduction was significant (p < 0.01). The correlation equation was pDOI = 0.81 × cDOI-0.23 (r = 0.73). Furthermore, re-analysis of the 39 cases revealed that pDOI = 0.84 × cDOI-0.37 (r = 0.62). Hence, a derived equation pDOI = 0.84 × (cDOI-0.44) was obtained to predict pDOI from cDOI. CONCLUSIONS: This study indicated that it is necessary to consider contraction due to specimen fixation by subtracting the thickness of the mucosal epithelium. Clinical T1 cases with a cDOI of 5 mm or less had a pDOI of 4 mm or less, and it would be expected to have low positive rate of neck lymph node metastasis.

DOI： 10.7759/cureus.34516

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分化度の異なる口腔扁平上皮癌におけるシスプラチンとCXCR4阻害剤併用の効果

吉田沙織, 河合穂高, 竹下洋平, 岡田俊輔, 藤倉満美子, 久富美紀, 河津俊幸, 長塚仁, 浅海淳一, 柳文修

日本口腔内科学会雑誌 28 ( 2 ) 106 - 106 2022年12月

Ultrasound procedure for the diagnosis of mass lesions in the oral region.

Yohei Takeshita, Toshiyuki Kawazu, Miki Hisatomi, Shunsuke Okada, Mamiko Fujikura, Saori Yoshida, Yuri Namba, Yudai Shimizu, Yoshinobu Yanagi, Junichi Asaumi

Oral radiology 39 ( 1 ) 93 - 100 2022年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: To examine the diagnostic usefulness and procedures of ultrasonography (US) for mass lesions in the soft tissue of the oral region. METHODS: This study involved patients with mass lesions (tumorous lesions and cysts) who had undergone US and histopathological examinations from January 2017 to December 2019. The following points were evaluated by two observers using an evaluation scale: vascularity, echo intensity level, boundary, margin shape, distribution of internal echoes, and capsule. The usefulness of each point for differential diagnosis of tumorous lesions and cysts was statistically analyzed. RESULTS: Forty-five mass lesions in the soft tissue of the oral region (33 tumorous lesions and 12 cysts) were analyzed. There were significant differences in four evaluation points between the tumorous lesions and cysts: vascularity, echo intensity level, boundary, and margin shape. Cysts were almost completely excluded diagnostically, especially when vascularity was observed. There were also significant differences in two evaluation points between nonvascular tumorous lesions and cysts: echo intensity level and boundary. CONCLUSIONS: In US examination for mass lesions in the oral region, it was possible to diagnose tumorous lesions and exclude cysts when vascularity was observed. When vascularity was not observed, however, tumorous lesions and cysts could be identified using two evaluation points: echo intensity level and boundary.

DOI： 10.1007/s11282-022-00605-2

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A Case of Odontogenic Myxoma of the Mandible with Expansion to the Alveolar Crest - Comparison of Imaging Findings and Pathological Findings: A Case Report 査読

Saori Yoshida, Yohei Takeshita, Toshiyuki Kawazu, Tatsushi Matsumura, Junichi Asaumi, Hitoshi Nagatsuka, Yoshinobu Yanagi

OPEN DENTISTRY JOURNAL 16 2022年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BENTHAM SCIENCE PUBL LTD

Background:An odontogenic myxoma is an intraosseous tumor characterized by stellate and spindle-shaped cells embedded in an abundant myxoid or mucoid extracellular matrix. We herein describe an odontogenic myxoma that expanded not only to the bone marrow but also to the outside of the alveolar bone. Diagnosis of an odontogenic myxoma in a tooth-deficient region by imaging findings alone was difficult because the positional relationship between the tumor and the tooth is unknown. Furthermore, some of these odontogenic myxomas reportedly show rapid growth.Case Report:Here, we present the case of a patient, a 44-year-old man, who had a hard, bone-like swelling on his right mandible molar region and mild paresthesia on his right cheek. An odontogenic myxoma and ameloblastoma were suspected based on the imaging findings; however, pathological examination of the biopsy led to a diagnosis of odontogenic myxoma. Right segmental mandibulectomy was performed, and there was no recurrence observed after surgery.Conclusion:To improve the accuracy of imaging diagnosis, it is important to compare the imaging findings with the pathological findings of the surgical specimen. This comparison in the present case revealed differences in the magnetic resonance imaging signal intensity in regions with different types of cell components.

DOI： 10.2174/18742106-v16-2202140

Web of Science

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Resident stroma-secreted chemokine CCL2 governs myeloid-derived suppressor cells in the tumor microenvironment 国際誌

May Wathone Oo, Hotaka Kawai, Kiyofumi Takabatake, Shuta Tomida, Takanori Eguchi, Kisho Ono, Qiusheng Shan, Toshiaki Ohara, Saori Yoshida, Haruka Omori, Shintaro Sukegawa, Keisuke Nakano, Kuniaki Okamoto, Akira Sasaki, Hitoshi Nagatsuka

JCI Insight 7 ( 1 ) 2021年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：American Society for Clinical Investigation

Accumulating evidence has shown that cancer stroma and BM-derived cells (BMDCs) in the tumor microenvironment (TME) play vital roles in tumor progression. However, the mechanism by which oral cancer stroma recruits any particular subset of BMDCs remains largely unknown. Here, we sought to identify the subset of BMDCs that is recruited by cancer stroma. We established a sequential transplantation model in BALB/c nude mice, including (a) BM transplantation of GFP-expressing cells and (b) coxenografting of patient-derived stroma (PDS; 2 cases, designated PDS1 and PDS2) with oral cancer cells (HSC-2). As controls, xenografting was performed with HSC-2 alone or in combination with normal human dermal fibroblasts (HDF). PDS1, PDS2, and HDF all promoted BMDC migration in vitro and recruitment in vivo. Multicolor immunofluorescence revealed that the PDS coxenografts recruited Arginase-1+CD11b+GR1+GFP+ cells, which are myeloid-derived suppressor cells (MDSCs), to the TME, whereas the HDF coxenograft did not. Screening using microarrays revealed that PDS1 and PDS2 expressed CCL2 mRNA (encoding C-C motif chemokine ligand 2) at higher levels than did HDF. Indeed, PDS xenografts contained significantly higher proportions of CCL2+ stromal cells and CCR2+Arginase-1+CD11b+GR1+ MDSCs (as receiver cells) than the HDF coxenograft. Consistently, a CCL2 synthesis inhibitor and a CCR2 antagonist significantly inhibited the PDS-driven migration of BM cells in vitro. Furthermore, i.p. injection of the CCR2 antagonist to the PDS xenograft models significantly reduced the CCR2+Arginase-1+CD11b+GR1+ MDSC infiltration to the TME. In conclusion, oral cancer stroma-secreted CCL2 is a key signal for recruiting CCR2+ MDSCs from BM to the TME.

DOI： 10.1172/jci.insight.148960

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Secretory Carcinoma of Salivary Gland with High-Grade Histology Arising in Hard Palate: A Case Report

Kiyofumi Takabatake, Keisuke Nakano, Hotaka Kawai, Saori Yoshida, Haruka Omori, May Wathone Oo, Shan Qiusheng, Kenichiro Uchida, Katsuaki Mishima, Hitoshi Nagatsuka

Reports — Medical Cases, Images, and Videos 3 ( 2 ) 6 - 6 2020年3月

掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

Secretory carcinoma (SC) is a recently described salivary gland tumor reported in the fourth edition of World Health Organization classification of head and neck tumors. SC is characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression, and harbors a t(12;15)(p13;q25) translocation which leads to ETV6-NTRK3 fusion product. Histologically, SC displays a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with abundant eosinophilic homogenous or bubbly secretion. SC is generally recognized as low-grade malignancy with low-grade histopathologic features, and metastasis is relatively uncommon. In this case, we described a SC of hard palate that underwent high grade transformation and metastasis to the cervical lymph node in a 54-year-old patient. In addition, this case showed different histological findings between primary lesion and metastasis lesion. Therefore, the diagnosis was confirmed by the presence of ETV6 translocation. Here, we report a case that occurred SC with high-grade transformation in the palate, and a review of the relevant literature is also presented.

DOI： 10.3390/reports3020006

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Differentiation and roles of bone marrow-derived cells on the tumor microenvironment of oral squamous cell carcinoma. 査読国際誌

Anqi C, Takabatake K, Kawai H, Oo MW, Yoshida S, Fujii M, Omori H, Sukegawa S, Nakano K, Tsujigiwa H, Jinhua Z, Nagatsuka H

Oncology letters 18 ( 6 ) 6628 - 6638 2019年12月

The Role of Sonic Hedgehog Signaling in the Tumor Microenvironment of Oral Squamous Cell Carcinoma. 査読国際誌

Kiyofumi Takabatake, Tsuyoshi Shimo, Jun Murakami, Chang Anqi, Hotaka Kawai, Saori Yoshida, May Wathone Oo, Omori Haruka, Shintaro Sukegawa, Hidetsugu Tsujigiwa, Keisuke Nakano, Hitoshi Nagatsuka

International journal of molecular sciences 20 ( 22 ) 2019年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

Sonic hedgehog (SHH) and its signaling have been identified in several human cancers, and increased levels of SHH expression appear to correlate with cancer progression. However, the role of SHH in the tumor microenvironment (TME) of oral squamous cell carcinoma (OSCC) is still unclear. No studies have compared the expression of SHH in different subtypes of OSCC and focused on the relationship between the tumor parenchyma and stroma. In this study, we analyzed SHH and expression of its receptor, Patched-1 (PTCH), in the TME of different subtypes of OSCC. Fifteen endophytic-type cases (ED type) and 15 exophytic-type cases (EX type) of OSCC were used. H&E staining, immunohistochemistry (IHC), double IHC, and double-fluorescent IHC were performed on these samples. ED-type parenchyma more strongly expressed both SHH and PTCH than EX-type parenchyma. In OSCC stroma, CD31-positive cancer blood vessels, CD68- and CD11b-positive macrophages, and α-smooth muscle actin-positive cancer-associated fibroblasts partially expressed PTCH. On the other hand, in EX-type stroma, almost no double-positive cells were observed. These results suggest that autocrine effects of SHH induce cancer invasion, and paracrine effects of SHH govern parenchyma-stromal interactions of OSCC. The role of the SHH pathway is to promote growth and invasion.

DOI： 10.3390/ijms20225779

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コレステリン肉芽腫の骨髄由来免疫抑制細胞(MDSC)の免疫組織化学的検討(Immunohistohemical examination of Myeloid-derived suppressor cells(MDSC) of cholesterol granuloma)

Nakano Keisuke, Kawai Hotaka, Takabatake Kiyofumi, Yoshida Saori, Omori Haruka, Nagatsuka Hitoshi, Kawakami Toshiyuki

Journal of Hard Tissue Biology 28 ( 4 ) 395 - 395 2019年10月

骨・軟骨形成に対するハニカムTCPの幾何学的構造の影響の解析と臨床応用(Analysis of the geometrical structure effect of honeycomb TCP on bone and cartilage formation and clinical application)

Takabatake Kiyofumi, Tsujigiwa Hidetsugu, Kawai Hotaka, Yoshida Saori, Omori Haruka, Nakano Keisuke, Kawakami Toshiyuki, Nagatsuka Hitoshi

Journal of Hard Tissue Biology 28 ( 4 ) 395 - 395 2019年10月

Tumor Angiogenic Inhibition Triggered Necrosis (TAITN) in Oral Cancer. 査読国際誌

Yoshida S, Kawai H, Eguchi T, Sukegawa S, Oo MW, Anqi C, Takabatake K, Nakano K, Okamoto K, Nagatsuka H

Cells 8 ( 7 ) 2019年7月

頭頸部再建における吻合血管の動脈硬化予測因子の検討査読

松谷瞳, 横川秀樹, 浅野悠, 吉田沙織, 浜田芽衣, 寺部雄太, 中塚貴志

形成外科 62 ( 7 ) 780 - 787 2019年7月

記述言語：日本語出版者・発行元：克誠堂出版(株)

2016年10月〜2017年12月に頭頸部癌に対し遊離皮弁で再建手術を行った60例(男39例、女21例、平均年齢65.8歳)を対象に、患者背景因子および移植遊離皮弁の種類、CT画像の頸部動脈石灰化所見について、吻合動脈の病理組織学的動脈硬化の程度との相関性を後方視的に評価した。背景因子のうち年齢と糖尿病が皮弁栄養動脈の動脈硬化と正の相関を示した。移植遊離皮弁別では空腸(22/23例)と腓骨皮弁(5/5例)はほぼ全例で栄養動脈に硬化を認めた。また腓骨皮弁では2/5例に皮弁栄養動脈内の石灰化を認めた。移植床動脈の動脈硬化は年齢と動脈硬化が正の相関を示した。Agatston石灰化スコアを参考に頸部動脈の石灰化値を計算した結果、動脈硬化がなかった症例は平均8.3、動脈硬化があった症例は平均18.6であった。

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Notch Signaling Affects Oral Neoplasm Cell Differentiation and Acquisition of Tumor-Specific Characteristics. 査読国際誌

Nakano K, Takabatake K, Kawai H, Yoshida S, Maeda H, Kawakami T, Nagatsuka H

International journal of molecular sciences 20 ( 8 ) 2019年4月

Importance of tumor budding grade as independent prognostic factor for early tongue squamous cell carcinoma. 査読国際誌

Ebihara Y, Yoshida S, Nakahira M, Kogashiwa Y, Enoki Y, Kuba K, Inoue H, Minami K, Yasuda M, Sugasawa M

Head & neck 41 ( 6 ) 1809 - 1815 2019年1月

Significance of PD-L1 Expression in Tongue Cancer Development 査読国際誌

Saori Yoshida, Hitoshi Nagatsuka, Keisuke Nakano, Yasunao Kogashiwa, Yasuhiro Ebihara, Mitsutake Yano, Masanori Yasuda

International Journal of Medical Sciences 15 ( 14 ) 1723 - 1730 2018年11月

Immune checkpoint inhibitors of CTLA4 and PD-1 for malignant melanoma arising in ovarian cystic teratoma: A case report. 査読国際誌

Yano M, Asami Y, Nishikawa T, Yoshida S, Kamada K, Katoh T, Teramoto Y, Nakamura Y, Yasuda M

Medicine 97 ( 43 ) e12937 2018年10月

口腔扁平上皮癌における腫瘍間質による腫瘍生物学特性の制御(Control of tumor biological character by tumor stroma in oral squamous cell carcinoma)

Takabatake Kiyofumi, Kawai Hotaka, Yoshida Saori, Matsuda Hiroyuki, Fujii Masae, Nakano Keisuke, Nagatsuka Hitoshi

Journal of Hard Tissue Biology 27 ( 4 ) 365 - 366 2018年10月

ハニカムTCP構造の幾何学構造が骨・軟骨形成および血管新生に及ぼす影響(Effects of the geometrical structure of a honeycomb TCP structure on bone and cartilage formation and angiogenesis)

Matsuda Hiroyuki, Takabatake Kiyofumi, Tsujigiwa Hidetsugu, Kawai Hotaka, Yoshida Saori, Nakano Keisuke, Nagatsuka Hitoshi

Journal of Hard Tissue Biology 27 ( 4 ) 367 - 367 2018年10月

Effects of the Geometrical Structure of a Honeycomb TCP on Relationship between Bone / Cartilage Formation and Angiogenesis. 査読国際誌

Matsuda H, Takabatake K, Tsujigiwa H, Watanabe S, Ito S, Kawai H, Hamada M, Yoshida S, Nakano K, Nagatsuka H

International journal of medical sciences 15 ( 14 ) 1582 - 1590 2018年

耳下腺に発生した上皮筋上皮癌の1例

吉田沙織, 加藤智美, 南和彦, 矢野光剛, 榊美佳, 永田耕治, 藤野節, 新井栄一, 長谷部孝裕, 安田政実

日本臨床細胞学会雑誌 56 ( Suppl.1 ) 311 - 311 2017年4月

GFPマウス骨髄移植モデルの異所性骨形成における骨髄由来細胞の役割(The role of bone marrow-derived cells in ectopic bone regeneration in the GFP mouse bone marrow transplantation model)

Yu Song, Takabatake Kiyofumi, Tsujigiwa Hidetsugu, Matsuda Hiroyuki, Kawai Hotaka, Yoshida Saori, Nakano Keisuke, Nagatsuka Hitoshi

Journal of Hard Tissue Biology 25 ( 4 ) 458 - 458 2016年10月

Expression and roles of CCN2 in dental mesenchymal cells in primary culture-With findings in a case of odontogenic myxofibroma. 査読国際誌

Shimo T, Koyama E, Horikiri Y, Okui T, Kurio N, Katase N, Yoshida S, Takebe Y, Kishimoto K, Yoshioka N, Nagatsuka H, Sasaki A

Oral Sci Int. 11 ( 1 ) 8 - 14 2014年1月

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