研究者詳細 - 阿部　匠

論文 - 阿部　匠

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2‐Hydroxy‐3‐(Pyrrolidin‐1‐yl)‐Indolines: A Platform for Accessing Decorated Deaminokynurenines Enabled by a Double Tautomeric Control 査読

Keisuke Tokushige, Takumi Abe

Asian Journal of Organic Chemistry 2025年5月

One-pot Stereoselective Synthesis of trans-2,3-Diaminoindolines through Differentiated 2,3-Diamination of Electrophilic Indolines

Yuito Kobori, Keisuke Tokushige, Takumi Abe

2025年4月

Molecular Iodine-Catalyzed Synthesis of 3,3-Disubstituted Isatins: Total Synthesis of Indole Alkaloid, 3,3-Dimethoxy-2-oxindole 招待査読

Keisuke Tokushige, Shota Asai, Takumi Abe

Chemistry 2025年3月

Perspectives of traditional herbal medicines in treating retinitis pigmentosa 査読

Shihui Liu, Toshihiko Matsuo, Chie Matsuo, Takumi Abe, Jinghua Chen, Chi Sun, Qing Zhao

Frontiers in Medicine 2024年12月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

<jats:p>Medicinal plants, also known as herbs, have been discovered and utilized in traditional medical practice since prehistoric times. Medicinal plants have been proven rich in thousands of natural products that hold great potential for the development of new drugs. Previously, we reviewed the types of Chinese traditional medicines that a Tang Dynasty monk Jianzhen (Japanese: Ganjin) brought to Japan from China in 742. This article aims to review the origin of Kampo (Japanese traditional medicine), and to present the overview of neurodegenerative diseases and retinitis pigmentosa as well as medicinal plants in some depth. Through the study of medical history of the origin of Kampo, we found that herbs medicines contain many neuroprotective ingredients. It provides us a new perspective on extracting neuroprotective components from herbs medicines to treat neurodegenerative diseases. Retinitis pigmentosa (one of the ophthalmic neurodegenerative diseases) is an incurable blinding disease and has become a popular research direction in global ophthalmology. To date, treatments for retinitis pigmentosa are very limited worldwide. Therefore, we intend to integrate the knowledge and skills from different disciplines, such as medical science, pharmaceutical science and plant science, to take a new therapeutic approach to treat neurodegenerative diseases. In the future, we will use specific active ingredients extracted from medicinal plants to treat retinitis pigmentosa. By exploring the potent bioactive ingredients present in medicinal plants, a valuable opportunity will be offered to uncover novel approaches for the development of drugs which target for retinitis pigmentosa.</jats:p>

DOI： 10.3389/fmed.2024.1468230

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Potassium tert‐Butoxide‐Mediated Ring‐Opening of Indolines: Concise Synthesis of 2‐Vinylanilines 招待査読

Keisuke Tokushige, Shota Asai, Takumi Abe

Asian Journal of Organic Chemistry 2024年11月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Wiley

A concise and metal‐free procedure has been developed for the synthesis of 2‐vinylanilines. Reactions of indolines with tert‐BuOK in DMSO afford the decorated 2‐vinylanilines in yields up to 92%. In addition, the 2, or 3‐substituted indolines could be converted to trisubstituted alkenes. Also, the protocol can be scaled to afford gram quantities of the decorated 2‐vinylanilines.

DOI： 10.1002/ajoc.202400552

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Azidoindolines—From Synthesis to Application: A Review 招待査読

Takumi Abe

Chemistry 2024年7月

Indoline hemiaminals: a platform for accessing anthranilic acid derivatives through oxidative deformylation 査読

Keisuke Tokushige, Yuito Kobori, Shota Asai, Takumi Abe

Organic & Biomolecular Chemistry 2024年7月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

<jats:p>Herein, we introduce a new synthetic protocol using 2-aminobenzoyl surrogates, allowing concise entry to decorated 2-aminobenzoyl derivatives in the absence of transition metals, acid chlorides, and specific reagents.</jats:p>

DOI： 10.1039/d4ob01218f

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Formal One Carbon Deletion of Indoline Hemiaminals under Tautomeric Control to Access 2-Aminobenzyl Compounds 査読

Keisuke Tokushige, Takumi Abe

The Journal of Organic Chemistry 2024年7月

Switchable Synthesis of 3-Aminoindolines and 2’-Aminoarylacetic Acids Using Grignard Reagents and 3-Azido-2-hydroxyindolines 査読

Toshiki Yamashiro, Takumi Abe

Chemical Communications 2024年5月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

<jats:p>The switchable synthesis of 3-aminoindolines and 2’-aminoaryl acetic acids from the same substrates, 3-azido-2-hydroxyindolines, was developed through denitogenative electrophilic amination of Grignard reagents. The key to success is the serendipitous...</jats:p>

DOI： 10.1039/d4cc01448k

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Synthetic strategies for the construction of C3–N1′ bisindoles 査読

Takumi Abe

Organic & Biomolecular Chemistry 2024年1月

担当区分：筆頭著者,　最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

<jats:p>Natural products having a C3–N1′ bisindole framework are unique structures with potential axial chirality. This minireview summarizes the recent progress of the methodology for constructing C3–N1′ bisindoles along with the possible mechanism.</jats:p>

DOI： 10.1039/d3ob02089d

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Concise Synthesis of Thiazolo[4,5‐b]indoles via Ring Switch/Cyclization Sequences 査読

Koji Yamada, Tetsu Tsubogo, Hikaru Kanazawa, Sayaka Ishizuka, Koutaro Ohyama, Masaki Kaida, Takumi Abe

European Journal of Organic Chemistry 2023年12月

Total Synthesis of the Proposed Structure of Indolyl 1,2-Propanediol Alkaloid, 1-(1H-Indol-3-yloxy)propan-2-ol 招待査読

Momoko Kimata, Takumi Abe

Chemistry 2023年12月

On Demand Synthesis of C3-N1' Bisindoles by a Formal Umpolung Strategy: First Total Synthesis of (±)-Rivularin A. 査読国際誌

Keisuke Tokushige, Takumi Abe

Chemistry (Weinheim an der Bergstrasse, Germany) e202302963 2023年11月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

In this work, a straightforward synthesis of C3-N1' bisindolines is achieved by a formal umpolung strategy. The protocols were tolerant of a wide variety of substituents on the indole and indoline ring. In addition, the C3-N1' bisindolines could be converted to C3-N1' indole-indolines and C3-N1'-bisindoles. Also, we have successfully synthesized (±)-rivularin A through a biomimetic late-stage tribromination as a key step.

DOI： 10.1002/chem.202302963

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Oxytrofalcatin Puzzle: Total Synthesis and Structural Revision of Oxytrofalcatins B and C 査読

Kazuma Sugitate, Toshiki Yamashiro, Ibuki Takahashi, Koji Yamada, Takumi Abe

The Journal of Organic Chemistry 88 ( 14 ) 2023年7月

One-Pot Synthesis of Core Structure of Shewanelline C Using an Azidoindoline 査読

Toshiki Yamashiro, Keisuke Tokushige, Takumi Abe

The Journal of Organic Chemistry 88 ( 6 ) 3992 - 3997 2023年3月

Aluminum-Catalyzed Cross Selective C3–N1′ Coupling Reactions of N-Methoxyindoles with Indoles 招待査読

Keisuke Tokushige, Toshiki Yamashiro, Seiya Hirao, Takumi Abe

Chemistry 5 ( 1 ) 452 - 462 2023年3月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

C3–N1′ bond formation of bisindoles has been a great challenge due to the intrinsic reactivity of indoles as both C3 and N1-nucleophilic character. Herein, we demonstrate an C3–N1′ cross-coupling reaction of indoles using N-methoxyindoles as N-electrophilic indole reagents in the presence of Lewis acid. The bisindoles generated in this transformation are latent C3-nucleophile, allowing them to be used as strategic intermediates in sequential C3–N1′–C3′–N1″ triindole formations. The potential synthetic usefulness of this sequential transformation was highlighted upon application to the construction of C3–N1 looped polyindoles.

DOI： 10.3390/chemistry5010033

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Revisiting Cryptocyanine Dye, NK-4, as an Old and New Drug: Review and Future Perspectives 査読

Shihui Liu, Toshihiko Matsuo, Takumi Abe

International Journal of Molecular Sciences 24 ( 5 ) 2023年2月

Synthesis of Spiro[indole-3,3′-pyrrolidine]-2′-(thi)ones 査読

Motohiro Yasui, Haruna Ohbu, Maho Ishikawa, Tatsuhito Yoshida, Norihiko Takeda, Seiya Hirao, Takumi Abe, Masafumi Ueda

The Journal of Organic Chemistry 88 ( 2 ) 1093 - 1106 2023年1月

Outstanding Reviewers for RSC Advances in 2022

Takumi Abe

RSC Advances 2023年

Traditional Chinese Medicines and Prescriptions Brought from China to Japan by a Monk (Jianzhen, Japanese: Ganjin): A Historical Review 招待査読

Shihui Liu, Toshihiko Matsuo, Chie Matsuo, Takumi Abe

Compounds 2 ( 4 ) 267 - 284 2022年10月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

(1) Background: Japanese Kampo medicine has its origin in ancient Chinese medicine. In 742, a Tang Dynasty monk named Jianzhen (Ganjin) was invited by Japanese clerics to visit Japan and teach commandments in Buddhism. Because of the dangers of the voyage and also other obstacles, he took 11 years to reach Japan on the sixth voyage and he was blind when he arrived in Japan. He was the first person in China to go to Japan to establish the Buddhism commandments, and he was also the first person in Japan to directly teach traditional Chinese medicine. Until now, there have been few reports in English about the details of the Chinese herbal medicines he brought to Japan, including the types of herbal medicines, pharmacological activities, and formulations. In the review, we systematically and comprehensively summarized Jianzhen’s life from the standpoint of his medical and pharmaceutical knowledge and the types and pharmacological activities of Chinese herbal medicines and prescriptions that were brought to Japan by Jianzhen; (2) Methods: A review was made on the relevant literature written by Chinese, Japanese, and English languages regarding the medical and pharmacological knowledge of Jianzhen, the 36 Chinese herbal medicines brought to Japan by Jianzhen, and the pharmacological and therapeutic effects of these 36 herbal medicines, as well as their formulations; (3) Results: The review of the literature proved that Jianzhen’s prescriptions served as a basis for current herbal medicines (Kampo) in Japan. In the process of the literature search, we found a book entitled Jianshangren (Holy Priest Jianzhen)’s Secret Prescription, which recorded the complete prescription of the 36 traditional Chinese medicines Jianzhen brought to Japan; (4) Conclusions: Jianzhen is one of the ancestors of traditional Chinese medicine/Kampo medicine, and he brought traditional Chinese medicine and medical books to Japan for patients. He made important contributions to the development of traditional Chinese medicine in Japan.

DOI： 10.3390/compounds2040022

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First Total Synthesis of Reassigned Echinosulfonic Acid D 査読

Takumi Abe, Ren Nakajima, Toshiki Yamashiro, Daisuke Sawada

Journal of Natural Products 85 ( 8 ) 2022年8月

Outstanding Reviewers for Organic & Biomolecular Chemistry in 2021

Takumi Abe

Organic & Biomolecular Chemistry 20 ( 28 ) 5499 - 5499 2022年7月

Indole Editing Enabled by HFIP-Mediated Ring-Switch Reactions of 3-Amino-2-Hydroxyindolines 査読

Abe, T., Yamashiro, T., Shimizu, K., Sawada, D.

Chemistry - A European Journal 28 ( 37 ) 2022年5月

Chemo- and Site-Selective Replacement of N-Terminal Carbamates in Peptides 査読

2022年3月

Synthesis of 2-monosubstituted indolin-3-ones by cine-substitution of 3-azido-2-methoxyindolines 招待査読

Toshiki Yamashiro, Takumi Abe, Daisuke Sawada

Organic Chemistry Frontiers 9 ( 7 ) 1897 - 1903 2022年2月

Cis-3-Azido-2-Methoxyindolines as Safe and Stable Precursors to Overcome the Instability of Fleeting 3-Azidoindoles 査読国際誌

Toshiki Yamashiro, Takumi Abe, Masaru Tanioka, Shinichiro Kamino, Daisuke Sawada

Chemical Communications 57 ( 98 ) 13381 - 13384 2021年11月

Synthesis of α-substituted indolylacetamide using acetonitriles as acetamide enolate equivalents through O-transfer reactions. 査読国際誌

Takumi Abe, Kenta Noda, Daisuke Sawada

Chemical communications (Cambridge, England) 57 ( 61 ) 7493 - 7496 2021年7月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

We introduce readily available ammonium hemiaminals as O-transfer reagents and commercially available acetonitriles as a primary amide enolate precursor. The combination serves as an amide enolate equivalent, thereby providing one-pot access to α-substituted indolylacetamides. A broad substrate scope and good functional group tolerance as well as gram-scale synthesis make this protocol highly attractive. Mechanistic experiments suggest that the cyano group is trapped by a hydroxy group of hemiaminals en route to the desired primary amides under metal-free conditions.

DOI： 10.1039/d1cc02821a

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A metal-, oxidant-, and fluorous solvent-free synthesis of alpha-indolylketones enabled by an umpolung strategy 査読

Takumi Abe, Seiya Hirao, Toshiki Yamashiro

CHEMICAL COMMUNICATIONS 56 ( 70 ) 10183 - 10186 2020年9月

レセルピンの立体化学表記の訂正

Takumi Abe

ファルマシア 2020年8月

Rapid access to indole-fused bicyclo[2.2.2]octanones by merging umpolung strategy and molecular iodine as a green catalyst 査読

Takumi Abe

Organic & Biomolecular Chemistry 2020年5月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

One-pot synthesis of indole-fused bicyclo[2.2.2]octanones from DiMeOIN and 2-cyclohexen-1-one are accomplished under iodine catalyst. This simple and metal-free conditions provides a practical tool to construct Csp3-rich complex molecules via oxidative...

DOI： 10.1039/d0ob01038c

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Revisiting 2-Alkoxy-3-bromoindolines: Control C-2 vs. C-3 Elimination for Regioselective Synthesis of Alkoxyindoles. 査読

Takumi Abe, Yuta Kosaka, Takaaki Kawasaki, Yuki Ohata, Toshiki Yamashiro, Koji Yamada

Chemical & pharmaceutical bulletin 68 ( 6 ) 555 - 558 2020年

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

The regioselective synthesis of both 2- and 3-alkoxyindoles from a common intermediate, 2-alkoxy-3-bromoindolines (ROBIN), is described. The 2-alkoxyindoles are obtained by a base-promoted regioselective elimination of HBr from ROBIN, whereas the synthesis of 3-alkoxyindoles is achieved by a silver-mediated alkoxylation followed by an acid-promoted elimination of alkoxide. This key elimination features the complete regioselectivity and no need for catalysts, that makes it have potential synthetic applications. Furthermore, this protocol is user friendly because ROBIN is able to be prepared from commercially available indoles and is a bench-stable easy-to-handle crystalline substrate, thus allowing the concise synthesis of a variety of both 2- and 3-alkoxyindoles.

DOI： 10.1248/cpb.c20-00135

PubMed

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2,3-Dimethoxyindolines: a latent electrophile for SNAr reactions triggered by indium catalysts 査読

Seiya Hirao, Toshiki Yamashiro, Kyouka Kohira, Naoki Mishima, Takumi Abe

Chemical Communications 2020年

A Mild Bischler–Napieralski-Type Cyclization of Trichloromethyl Carbamates for the Synthesis of β-Carbolinones 査読

HETEROCYCLES 101 ( 1 ) 2020年

インドール-2,3-エポキシド代替品の開発と応用査読

阿部匠, 山田康司, 西剛秀

有機合成化学協会誌 78 ( 6 ) 597 - 607 2020年

担当区分：筆頭著者,　責任著者記述言語：日本語出版者・発行元：公益社団法人有機合成化学協会

C3-Nucleophilic substitution of indoles has been limited because the transformation requires an umpolung of the C3 position of indoles. Among the indole derivatives, indole-2,3-epoxides could be potentially be used as C3-electrophilic reagents due to the electrophilic nature of the C2 and C3 positions. However, their use as C3 electrophilic reagents has not been possible so far due to their instability.We describe a novel and bench stable surrogate of indole-2,3-epoxide, 2-hydroxyindoline-3-triethylammonium bromide (HITAB), which was found to be a convenient reagent for formal C3-electrophilic reactions of indoles with nucleophiles. By taking advantage of the nucleophilic character of the oxygen of the 2-hydroxyindoline, interrupted retro-Claisen and interrupted Feist-Bénary reactions with 1,3-dicarbonyl compounds, one-pot formation of furodiindolines from 3-substituted indoles were achieved. Furthermore, we developed a novel cascade reaction of the indole-2,3-epoxide surrogate with γ-carbolines to access multiheterocyclic compounds containing both isotryptamines and pyrimido［1,6-a］indoles. This reaction utilizes the in situ formation of a bulky quaternary ammonium salt via ammonium exchange, which undergoes Hofmann elimination/vinylogous Mannich/retro-Mannich/cyclization cascade sequences. The synthetic potential of the ammonium salts was demonstrated by the short synthesis of cryptolepine, iheyamine A, racemocine B derivative, and neocryptolepine derivative.

DOI： 10.5059/yukigoseikyokaishi.78.597

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Rapid access to indole-fused bicyclo[2.2.2]octanones by merging the umpolung strategy and molecular iodine as a green catalyst

Abe, T., Hirao, S.

Organic and Biomolecular Chemistry 18 ( 22 ) 2020年

Rapid access to indole-fused bicyclo[2.2.2]octanones by merging the umpolung strategy and molecular iodine as a green catalyst

Takumi Abe, Seiya Hirao

Organic & Biomolecular Chemistry 18 ( 22 ) 2020年

Silver-Mediated Intramolecular Friedel–Crafts-Type Cyclizations of 2-Benzyloxy-3-bromoindolines: Synthesis of Isochromeno[3,4-b] indolines and 3-Arylindoles 査読

Synlett 30 ( 20 ) 2247 - 2252 2019年11月

Total Synthesis of Fontanesine B and Its Isomer: Their Antiproliferative Activity against Human Colorectal Cancer Cells 査読国際誌

Takumi Abe

Helvetica Chimica Acta 102 ( 7 ) 2019年6月

Total Synthesis of Proposed Structure of Azepinobisindole Alkaloid Rhodozepinone 査読

Takumi Abe

HETEROCYCLES 98 ( 6 ) 2019年5月

Revisiting Furodiindolines: One-Pot Synthesis of Furodiindolines Using Indole 2,3-Epoxide Surrogates and Their Synthetic Applications 査読

Organic Letters 21 ( 9 ) 3367 - 3371 2019年4月

Direct C4-Benzylation of Indoles via Tandem Benzyl Claisen/Cope Rearrangements 査読

Takumi Abe, Yuta Kosaka, Miku Asano, Natsuki Harasawa, Akane Mishina, Misato Nagasue, Yuri Sugimoto, Kazuaki Katakawa, Shunsuke Sueki, Masahiro Anada, Koji Yamada

Organic Letters 21 ( 3 ) 826 - 829 2019年2月

Total synthesis of pyrano[3,2-e]indole alkaloid fontanesine B by a double cyclization strategy 査読

Tomoki Itoh, Yuusuke Chiba, Shunsuke Kawaguchi, Yuki Koitaya, Yuuma Yoneta, Koji Yamada, Takumi Abe

RSC Advances 9 ( 18 ) 10420 - 10424 2019年

Biomimetic Synthesis of Iheyamine A from Spirocyclic Oxindoles 査読

Takumi Abe, Koji Yamada, Syuhei Satake

HETEROCYCLES 99 ( 0 ) 379 - 379 2019年

Double “Open and Shut” Transformation of γ-Carbolines Triggered by Ammonium Salts: One-Pot Synthesis of Multiheterocyclic Compounds 査読

Takumi Abe, Haruka Shimizu, Shiori Takada, Takahiro Tanaka, Mai Yoshikawa, Koji Yamada

Organic Letters 20 ( 6 ) 1589 - 1592 2018年3月

Dehydrative Mannich-Type Reaction for the Synthesis of Azepinobisindole Alkaloid Iheyamine A 査読

Takumi Abe, Koji Yamada

Organic Letters 20 ( 5 ) 1469 - 1472 2018年3月

Synthesis of Phaitanthrin E and Tryptanthrin through Amination/Cyclization Cascade 査読

Takumi Abe, Masaru Terasaki

Helvetica Chimica Acta 101 ( 2 ) e1700284 2018年2月

Nazarov cyclization of an indolyl vinyl ketone promoted by acetyl chloride and sodium iodide: Formal synthesis of Bruceolline e 査読

Takumi Abe

Heterocycles 96 ( 3 ) 490 - 500 2018年

カスケード反応を用いたインドロキナゾリンアルカロイドの合成研究査読

阿部匠

有機合成化学協会誌 76 ( 8 ) 802 - 809 2018年

担当区分：筆頭著者,　最終著者,　責任著者記述言語：日本語出版者・発行元：公益社団法人有機合成化学協会

We describe the total synthesis of indolo[2,1-b]quinazoline alkaloids tryptanthrin (1a), candidine (2), phaitanthrins A (3), B (4), C (5), cruciferane (8), and cephalanthrin A (9) using oxidative cascade sequences as the key step. Phaitanthrin E (7a) was synthesized by a novel methodology that features a concise approach involving the intermolecular condensation and intramolecular aryl C-H amination mediated by Cu-complexes to construct the indolo[2,1-b]quinazoline core. Moreover, an acid catalyzed one-pot synthesis of phaitanthrin E (7a) via intermolecular amination/intramolecular cyclization cascade using NCS was also developed.

DOI： 10.5059/yukigoseikyokaishi.76.802

CiNii Article

CiNii Books

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Radical Cyclizations of Aryl Bromides for Synthesis of Cyclopenta[b]Indoles from Vince Lactam 査読

Takumi Abe, Tsuyoshi Morita, Koji Yamada

HETEROCYCLES 97 ( 0 ) 141 - 141 2018年

An Ullmann N-arylation/2-amidation cascade by self-relay copper catalysis: one-pot synthesis of indolo[1,2-a]quinazolinones 査読

Takumi Abe, Yuka Takahashi, Yuki Matsubara, Koji Yamada

ORGANIC CHEMISTRY FRONTIERS 4 ( 11 ) 2124 - 2127 2017年11月

C4 Pictet–Spengler Reactions for the Synthesis of Core Structures in Hyrtiazepine Alkaloids 査読

Takumi Abe, Koji Yamada, Tomohiro Haruyama

Synthesis 49 ( 18 ) 4141 - 4150 2017年9月

2-Hydroxyindoline-3-triethylammonium Bromide: A Reagent for Formal C3-Electrophilic Reactions of Indoles 査読

Takumi Abe, Takuro Suzuki, Masahiro Anada, Shigeki Matsunaga, Koji Yamada

ORGANIC LETTERS 19 ( 16 ) 4275 - 4278 2017年8月

A copper-catalyzed Ritter-type cascade via iminoketene for the synthesis of quinazolin-4(3H)-ones and diazocines 査読

Takumi Abe, Koshiro Kida, Koji Yamada

CHEMICAL COMMUNICATIONS 53 ( 31 ) 4362 - 4365 2017年4月

Concise Syntheses of Hyrtioreticulins C and D via a C-4 Pictet–Spengler Reaction: Revised Signs of Specific Rotations 査読

Takumi Abe, Koji Yamada

Journal of Natural Products 80 ( 2 ) 241 - 245 2017年2月

One-pot synthesis of fused 2-pyridones from heteroarylacrylic acid via curtius rearrangement & microwave-assisted thermal electrocyclization 査読

Takashi Nishiyama, Noriyuki Hatae, Kaori Hayashi, Manami Obata, Kimiko Taninaka, Masahiro Yamane, Shota Oda, Takumi Abe, Minoru Ishikura, Satoshi Hibino, Tominari Choshi

Heterocycles 95 ( 1 ) 251 - 267 2017年

SYNTHESIS OF (+/-)-CEPHALANTHRIN A USING BAEYER-VILLIGER OXIDATION

Takumi Abe

Heterocycles 95 ( 1 ) 2017年

Amination/Cyclization Cascade by Acid-Catalyzed Activation of Indolenine for the One-Pot Synthesis of Phaitanthrin E 査読

Takumi Abe, Koji Yamada

ORGANIC LETTERS 18 ( 24 ) 6504 - 6507 2016年12月

Concise synthesis of carbazole-1,4-quinones and evaluation of their antiproliferative activity against HCT-116 and HL-60 cells 査読

Takashi Nishiyama, Noriyuki Hatae, Teruki Yoshimura, Sawa Takaki, Takumi Abe, Minoru Ishikura, Satoshi Hibino, Tominari Choshi

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 121 561 - 577 2016年10月

Synthesis of (±)-Cephalanthrin A using Baeyer-Villiger Oxidation

Takumi Abe

Heterocycles 2016年6月

A ONE-POT SYNTHESIS OF PHAITANTHRIN E THROUGH INTERMOLECULAR CONDENSATION/INTRAMOLECULAR ARYL C-H AMINATION CASCADE 査読

Tomoki Itoh, Takumi Abe, Tominari Choshi, Takashi Nishiyama, Minoru Ishikura

HETEROCYCLES 92 ( 6 ) 1132 - 1136 2016年6月

Concise Total Syntheses of Pyrido[4,3-b]carbazole Alkaloids Using Copper-Mediated 6π-Electrocyclization 査読

Tomoki Itoh, Takumi Abe, Tominari Choshi, Takashi Nishiyama, Reiko Yanada, Minoru Ishikura

European Journal of Organic Chemistry 2016 ( 13 ) 2290 - 2299 2016年5月

TOTAL SYNTHESIS OF CARBAZOLE-1,4-QUINONE ALKALOID KOENIGINEQUINONES A AND B BASED ON A ONE-POT CYCLOCARBONYLATION PROCEDURE FROM 2-ALKENYL-3-IODOINDOLE 査読

Takashi Nishiyama, Nanase Satsuki, Satoshi Hibino, Mami Fujii, Takumi Abe, Minoru Ishikura, Tominari Choshi

HETEROCYCLES 93 ( 1 ) 84 - 100 2016年4月

クロスカップリング反応を基軸とするインドールアルカロイドの合成査読

阿部匠, 石倉稔

有機合成化学協会誌 74 ( 2 ) 117 - 129 2016年

Cu-MEDIATED OXIDATIVE DIMERIZATION OF SKATOLE TO TRYPTANTHRIN, AN INDOLO[2,1-b]QUINAZOLONE ALKALOID 査読

Tomoki Itoh, Takumi Abe, Shuhei Nakamura, Minoru Ishikura

HETEROCYCLES 91 ( 7 ) 1423 - 1428 2015年7月

Pd-CATALYZED INTRAMOLECULAR OXIDATIVE COUPLING REACTION OF 1,1 '-CARBONYLDIINDOLES

Takumi Abe, Minoru Ishikura

HETEROCYCLES 90 ( 1 ) 673 - 680 2015年1月

Simple indole alkaloids and those with a nonrearranged monoterpenoid unit 査読

Minoru Ishikura, Takumi Abe, Tominari Choshi, Satoshi Hibino

NATURAL PRODUCT REPORTS 32 ( 10 ) 1389 - 1471 2015年

N-Substituted calothrixin B derivatives inhibited the proliferation of HL-60 promyelocytic leukemia cells 査読

Noriyuki Hatae, Risa Satoh, Hitomi Chiba, Takahiro Osaki, Takashi Nishiyama, Minoru Ishikura, Takumi Abe, Satoshi Hibino, Tominari Choshi, Chiaki Okada, Eiko Toyota

MEDICINAL CHEMISTRY RESEARCH 23 ( 11 ) 4956 - 4961 2014年11月

One-pot synthesis of tryptanthrin by the Dakin oxidation of indole-3-carbaldehyde 査読

Takumi Abe, Tomoki Itoh, Tominari Choshi, Satoshi Hibino, Minoru Ishikura

TETRAHEDRON LETTERS 55 ( 38 ) 5268 - 5270 2014年9月

A novel one-pot synthesis of carbazole-1,4-quinones through Pd-catalyzed cyclocarbonylation, desilylation and oxidation processes from 3-iodo-2-propenylindoles 査読

Mami Fujii, Takashi Nishiyama, Tominari Choshi, Nanase Satsuki, Takaya Fujiwaki, Takumi Abe, Minoru Ishikura, Satoshi Hibino

TETRAHEDRON 70 ( 9 ) 1805 - 1810 2014年3月

ONE-POT ACCESS TO 3,3 '-BISINDOLYLMETHANES THROUGH THE INTERMOLECULAR PUMMERER REACTION 査読

Takumi Abe, Toshiaki Ikeda, Tomoki Itoh, Noriyuki Hatae, Eiko Toyota, Minoru Ishikura

HETEROCYCLES 88 ( 1 ) 187 - 191 2014年1月

Effect of the orthoquinone moiety in 9,10-phenanthrenequinone on its ability to induce apoptosis in HCT-116 and HL-60 cells 査読

Noriyuki Hatae, Jun Nakamura, Tetsuo Okujima, Minoru Ishikura, Takumi Abe, Satoshi Hibino, Tominari Choshi, Chiaki Okada, Hiroko Yamada, Hidemitsu Uno, Eiko Toyota

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23 ( 16 ) 4637 - 4640 2013年8月

Biomimetic transamination of α-keto esters 査読

Takumi Abe

Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry 71 ( 1 ) 62 - 63 2013年7月

One-pot construction of 3,3′-bisindolylmethanes through Bartoli indole synthesis 査読

Takumi Abe, Shuuhei Nakamura, Reiko Yanada, Tominari Choshi, Satoshi Hibino, Minoru Ishikura

Organic Letters 15 ( 14 ) 3622 - 3625 2013年7月

Simple indole alkaloids and those with a non-rearranged monoterpenoid unit 査読

Minoru Ishikura, Takumi Abe, Tominari Choshi, Satoshi Hibino

NATURAL PRODUCT REPORTS 30 ( 5 ) 694 - 752 2013年

多官能性合成素子を用いるインドール化合物の合成査読

阿部匠

薬学雑誌 133 ( 1 ) 99 - 106 2013年

SHORT APPROACH TO BISINDOLE ALKALOID, YUEHCHUKENE, USING 2-INDOLYLCYANOCUPRATE

Takumi Abe, Hiroyuki Komatsu, Toshiaki Ikeda, Noriyuki Hatae, Eiko Toyota, Minoru Ishikura

HETEROCYCLES 86 ( 1 ) 505 - 513 2012年12月

Total Synthesis of Calothrixins A and B by Palladium-Catalyzed Tandem Cyclization/Cross-Coupling Reaction of Indolylborate

Takumi Abe, Toshiaki Ikeda, Tominari Choshi, Satoshi Hibino, Noriyuki Hatae, Eiko Toyata, Reiko Yanada, Minoru Ishikura

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2012 ( 26 ) 5018 - 5027 2012年9月

Synthesis and antimalarial activity of calothrixins A and B, and their N-alkyl derivatives 査読

Kohji Matsumoto, Tominari Choshi, Mai Hourai, Yoshito Zamami, Kenji Sasaki, Takumi Abe, Minoru Ishikura, Noriyuki Hatae, Tatsunori Iwamura, Shigeo Tohyama, Junko Nobuhiro, Satoshi Hibino

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22 ( 14 ) 4762 - 4764 2012年7月

Concise Total Synthesis of Calothrixins A and B 査読

Takumi Abe, Toshiaki Ikeda, Reiko Yanada, Minoru Ishikura

ORGANIC LETTERS 13 ( 13 ) 3356 - 3359 2011年7月

FACILE SYNTHESIS OF PYRANO[3,2-e]INDOLES VIA THE BASE-PROMOTED PICTET-SPENGLER REACTION OF N-b-BENZYLSEROTONIN

Koji Yamada, Sayaka Yamaguchi, Noriyuki Hatae, Takumi Abe, Tatsunori Iwamura, Minoru Ishikura

HETEROCYCLES 83 ( 4 ) 815 - 826 2011年4月

Metal-Catalyzed Reactions between 2-Azabicyclo[2.2.1]hept-5-en-3-ones and Arylboronic Acids 査読

Takumi Abe, Hiroyuki Takeda, Yumi Takahashi, Yoshihisa Miwa, Koji Yamada, Minoru Ishikura

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2010 ( 17 ) 3281 - 3294 2010年6月

Simple indole alkaloids and those with a nonrearranged monoterpenoid unit 査読

Minoru Ishikura, Koji Yamada, Takumi Abe

NATURAL PRODUCT REPORTS 27 ( 11 ) 1630 - 1680 2010年

Copper-Catalyzed Ritter-Type Reaction of Unactivated Alkenes with Dichloramine-T

Takumi Abe, Hiroyuki Takeda, Yoshihisa Miwa, Koji Yamada, Reiko Yanada, Minoru Ishikura

HELVETICA CHIMICA ACTA 93 ( 2 ) 233 - 241 2010年

Revisiting AI-2 Quorum Sensing Inhibitors: Direct Comparison of Alkyl-DPD Analogues and a Natural Product Fimbrolide 査読

Colin A. Lowery, Takumi Abe, Junguk Park, Lisa M. Eubanks, Daisuke Sawada, Gunnar F. Kaufmann, Kim D. Janda

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 131 ( 43 ) 15584 - + 2009年11月

Reaction of Nβ-benzylserotonin with α,β- unsaturated and aryl aldehydes in the presence of a base 査読

Koji Yamada, Yuichi Namerikawa, Takumi Abe, Minoru Ishikura

Heterocycles 77 ( 2 ) 825 - 828 2009年2月

RHODIUM-CATALYZED ARYLATION OF 2-AZABICYCLO[2.2.1]HEPT-5-EN-3-ONE WITH ARYLBORONIC ACIDS UNDER MICROWAVE IRRADIATION 査読

Takumi Abe, Hiroyuki Takeda, Yumi Takahashi, Yoshihisa Miwa, Koji Yamada, Minoru Ishikura

HETEROCYCLES 75 ( 12 ) 2931 - 2936 2008年12月

A concise approach to (±)-tubifoline based on the palladium-catalyzed cross-coupling reaction of indolylborate 査読

Minoru Ishikura, Norinobu Takahashi, Koji Yamada, Takumi Abe

Heterocycles 75 ( 1 ) 107 - 118 2008年1月

Formal Synthesis of Olivacine via Indolylborate 査読

Minoru Ishikura, Norinobu Takahashi, Koji Yamada, Takumi Abe, Reiko Yanada

HELVETICA CHIMICA ACTA 91 ( 10 ) 1828 - 1837 2008年

Copper-catalyzed N-arylation reaction of 2-azabicyclo[2.2.1]hept-5-en-3-one with arylboronic acids under microwave irradiation 査読

Takumi Abe, Hiroyuki Takeda, Koji Yamada, Minoru Ishikura

Heterocycles 76 ( 1 ) 133 - 136 2008年

Asymmetric syntheses of diarylheptanoid natural products (-)-centrolobine and (-)-de-O-methylcentrolobine via hetero-Diels-Alder reaction catalyzed by dirhodium(II) tetrakis[(R)-3-(benzene-fused-phthalimido)-2-piperidinonate] 査読

Takuya Washio, Reika Yamaguchi, Takumi Abe, Hisanori Nambu, Masahiro Anada, Shunichi Hashimoto

TETRAHEDRON 63 ( 48 ) 12037 - 12046 2007年11月

Catalytic enantioselective Amination of silyl enol ethers using chiral Dirhodium(II) carboxylates: Asymmetric formal synthesis of (-)-metazocine 査読

Masahiro Anada, Masahiko Tanaka, Takuya Washio, Minoru Yamawaki, Takumi Abe, Shunichi Hashimoto

ORGANIC LETTERS 9 ( 22 ) 4559 - 4562 2007年10月

Catalytic enantioselective aziridination of alkenes using chiral dirhodium(II) carboxylates 査読

Minoru Yamawaki, Masahiko Tanaka, Takumi Abe, Masahiro Anada, Shunichi Hashimoto

HETEROCYCLES 72 709 - 721 2007年4月

Catalytic enantioselective tandem carbonyl ylide formation/1,3 dipolar cycloaddition reactions of α-diazo ketones with aromatic aldehydes using dirhodium(II) tetrakis[N-benzene-fusedphthaloyl- (S)-valinate] 査読

Hideyuki Tsutsui, Naoyuki Shimada, Takumi Abe, Masahiro Anada, Makoto Nakajima, Seiichi Nakamura, Hisanori Nambu, Shunichi Hashimoto

Advanced Synthesis and Catalysis 349 ( 4-5 ) 521 - 526 2007年3月

Investigation of the regioselectivity on the reaction of 2-indolylcyanocuprate with N-(prop-2-en-1-ylidene)aminium chloride derivatives 査読

Minoru Ishikura, Hiroyuki Komatsu, Koji Yamada, Takumi Abe, Reiko Yanada

HETEROCYCLES 71 ( 11 ) 2325 - 2329 2007年

Practical synthesis of dirhodium(II) Tetrakis[N-phthaloyl-(S)-tert-leucinate] 査読

H Tsutsui, T Abe, S Nakamura, M Anada, S Hashimoto

CHEMICAL & PHARMACEUTICAL BULLETIN 53 ( 10 ) 1366 - 1368 2005年10月

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