Updated on 2025/10/31

写真a

 
Akashi Sho
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Assistant Professor
Position
Assistant Professor
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Education

  • Okayama University   大学院医歯薬学総合研究科   顎口腔再建外科学分野

    2015.4 - 2019.3

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    Country: Japan

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  • Okayama University   歯学部   歯学科

    2008.4 - 2014.3

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    Country: Japan

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Papers

  • A case of multicentric reticulohistiocytosis with multiple nodules in the oral cavity Reviewed

    Sho Akashi, Tatsushi Matsumura, Yohsuke Yoshioka, Koichi Sawaki, Makoto Nakano, Seiji Iida

    Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   37 ( 4 )   718 - 723   2025.7

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.ajoms.2025.01.007

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  • Sturge-Weber syndrome with cemento-ossifying fibroma in the maxilla and giant odontoma in the mandible: A case report Reviewed

    Aki Sato, Hisako Furusho, Tatsushi Matsumura, Makoto Nakano, Koichi Sawaki, Yohsuke Yoshioka, Sho Akashi, Mutsumi Miyauchi, Nobuyoshi Mizukawa, Seiji Iida

    Heliyon   10 ( 8 )   e29445 - e29445   2024.4

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    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.heliyon.2024.e29445

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  • Effect of Episil® oral liquid on eating and swallowing functions of patients with oral mucositis: a retrospective observational study

    Yohsuke Yoshioka, Koichi Sawaki, Sho Akashi, Makoto Nakano

    Oral Science in Japan   7 - 8   2022

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  • A case of rhabdomyomatous mesenchymal hamartoma occurring on the inferior lingual surface Reviewed

    Koichi SAWAKI, Tatsushi MATSUMURA, Yuki FUJITA, Yohsuke YOSHIOKA, Sho AKASHI, Makoto NAKANO

    Japanese Journal of Oral and Maxillofacial Surgery   67 ( 9 )   514 - 519   2021.9

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    Publishing type:Research paper (scientific journal)   Publisher:Japanese Society of Oral and Maxillofacial Surgeons  

    DOI: 10.5794/jjoms.67.514

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  • Effect of Angiotensin II on Chondrocyte Degeneration and Protection via Differential Usage of Angiotensin II Receptors Reviewed

    Takashi Nishida, Sho Akashi, Masaharu Takigawa, Satoshi Kubota

    International Journal of Molecular Sciences   22 ( 17 )   9204 - 9204   2021.8

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    Publishing type:Research paper (scientific journal)   Publisher:MDPI AG  

    The renin–angiotensin system (RAS) controls not only systemic functions, such as blood pressure, but also local tissue-specific events. Previous studies have shown that angiotensin II receptor type 1 (AT1R) and type 2 (AT2R), two RAS components, are expressed in chondrocytes. However, the angiotensin II (ANG II) effects exerted through these receptors on chondrocyte metabolism are not fully understood. In this study, we investigated the effects of ANG II and AT1R blockade on chondrocyte proliferation and differentiation. Firstly, we observed that ANG II significantly suppressed cell proliferation and glycosaminoglycan content in rat chondrocytic RCS cells. Additionally, ANG II decreased CCN2, which is an anabolic factor for chondrocytes, via increased MMP9. In Agtr1a-deficient RCS cells generated by the CRISPR-Cas9 system, Ccn2 and Aggrecan (Acan) expression increased. Losartan, an AT1R antagonist, blocked the ANG II-induced decrease in CCN2 production and Acan expression in RCS cells. These findings suggest that AT1R blockade reduces ANG II-induced chondrocyte degeneration. Interestingly, AT1R-positive cells, which were localized on the surface of the articular cartilage of 7-month-old mice expanded throughout the articular cartilage with aging. These findings suggest that ANG II regulates age-related cartilage degeneration through the ANG II–AT1R axis.

    DOI: 10.3390/ijms22179204

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  • RFX1‐mediated CCN3 induction that may support chondrocyte survival under starved conditions Reviewed

    Tomomi Mizukawa, Takashi Nishida, Sho Akashi, Kazumi Kawata, Sumire Kikuchi, Harumi Kawaki, Masaharu Takigawa, Hiroshi Kamioka, Satoshi Kubota

    Journal of Cellular Physiology   236 ( 10 )   6884 - 6896   2021.3

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    Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    Abstract

    Cellular communication network factor (CCN) family members are multifunctional matricellular proteins that manipulate and integrate extracellular signals. In our previous studies investigating the role of CCN family members in cellular metabolism, we found three members that might be under the regulation of energy metabolism. In this study, we confirmed that CCN2 and CCN3 are the only members that are tightly regulated by glycolysis in human chondrocytic cells. Interestingly, CCN3 was induced under a variety of impaired glycolytic conditions. This CCN3 induction was also observed in two breast cancer cell lines with a distinct phenotype, suggesting a basic role of CCN3 in cellular metabolism. Reporter gene assays indicated a transcriptional regulation mediated by an enhancer in the proximal promoter region. As a result of analyses in silico, we specified regulatory factor binding to the X‐box 1 (RFX1) as a candidate that mediated the transcriptional activation by impaired glycolysis. Indeed, the inhibition of glycolysis induced the expression of RFX1, and RFX1 silencing nullified the CCN3 induction by impaired glycolysis. Subsequent experiments with an anti‐CCN3 antibody indicated that CCN3 supported the survival of chondrocytes under impaired glycolysis. Consistent with these findings in vitro, abundant CCN3 production by chondrocytes in the deep zones of developing epiphysial cartilage, which are located far away from the synovial fluid, was confirmed in vivo. Our present study uncovered that RFX1 is the mediator that enables CCN3 induction upon cellular starvation, which may eventually assist chondrocytes in retaining their viability, even when there is an energy supply shortage.

    DOI: 10.1002/jcp.30348

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    Other Link: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jcp.30348

  • 当院における手術前周術期患者の口腔内の状況と口腔清掃習慣に関する調査

    北山 美穂, 澤木 康一, 若松 和子, 三島 久美, 炭本 有希, 中村 真弓, 藤井 博美, 吉岡 洋祐, 明石 翔, 中野 誠, 品川 佳子

    広島市民病院医誌   67   514 - 519   2021

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  • Regulation of cellular communication network factor 2 (CCN2) in breast cancer cells via the cell-type dependent interplay between CCN2 and glycolysis Reviewed

    Sho Akashi, Takashi Nishida, Tomomi Mizukawa, Kazumi Kawata, Masaharu Takigawa, Seiji Iida, Satoshi Kubota

    Journal of Oral Biosciences   62 ( 3 )   280 - 288   2020.9

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.job.2020.07.001

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  • Intermittent parathyroid hormone 1–34 induces oxidation and deterioration of mineral and collagen quality in newly formed mandibular bone Reviewed

    Yohsuke Yoshioka, Eiki Yamachika, Makoto Nakanishi, Tadashi Ninomiya, Sho Akashi, Sei Kondo, Norifumi Moritani, Yasuhiro Kobayashi, Tatsuo Fujii, Seiji Iida

    Scientific Reports   9 ( 1 )   2019.5

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    Intermittent parathyroid hormone (PTH) administration is known to promote bone healing after surgical procedures. However, the mechanism and influence of PTH on the mineral and collagen quality of the jaw are not well understood. Most studies have focused on analyzing the bone density and microstructure of the mandible, and have insufficiently investigated its mineral and collagen quality. Oxidative stress activates osteoclasts, produces advanced glycation end products, and worsens mineral and collagen quality. We hypothesized that PTH induces oxidation and affects the mineral and collagen quality of newly formed mandibular bone. To test this, we examined the mineral and collagen quality of newly formed mandibular bone in rats administered PTH, and analyzed serum after intermittent PTH administration to examine the degree of oxidation. PTH administration reduced mineralization and worsened mineral and collagen quality in newly formed bone. In addition, total anti-oxidant capacity in serum was significantly decreased and the oxidative-INDEX was increased among PTH-treated compared to vehicle-treated rats, indicating serum oxidation. In conclusion, intermittent administration of PTH reduced mineral and collagen quality in newly formed mandibular bone. This effect may have been induced by oxidation.

    DOI: 10.1038/s41598-019-44389-8

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    Other Link: https://www.nature.com/articles/s41598-019-44389-8

  • 二卵性双生児に見られた22q11.2欠失症候群 Reviewed

    有村 友紀, 松村 達志, 水谷 雅英, 植松 彩, 松井 裕一, 岡田 亜由美, 田畑 光康, 明石 翔, 中川 敦子, 飯田 征二

    岡山歯学会雑誌   37   37 - 42   2018

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  • Metabolic regulation of the CCN family genes by glycolysis in chondrocytes Invited Reviewed

    Sho Akashi, Takashi Nishida, Abdellatif El-Seoudi, Masaharu Takigawa, Seiji Iida, Satoshi Kubota

    Journal of Cell Communication and Signaling   12 ( 1 )   245 - 252   2017.11

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:Wiley  

    DOI: 10.1007/s12079-017-0420-8

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    Other Link: http://link.springer.com/content/pdf/10.1007/s12079-017-0420-8.pdf

  • A case of non-clostridial gas gangrene caused by antiresorptive agent-related osteonecrosis of the jaw Reviewed

    Masakazu MATSUBARA, Nobuhisa ISHIDA, Atsushi IKEDA, Eiki YAMACHIKA, Sho AKASHI, Seiji IIDA

    Japanese Journal of Oral and Maxillofacial Surgery   63 ( 10 )   506 - 511   2017

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    Publishing type:Research paper (scientific journal)   Publisher:Japanese Society of Oral and Maxillofacial Surgeons  

    DOI: 10.5794/jjoms.63.506

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Presentations

  • エナメル上皮腫の増殖および開窓術による腫瘍縮小に対するHIF-1αの関連

    石田修一, 高畠清文, 天野克比古, 有村友紀, 明石翔, 長塚仁, 飯田征二

    第70回日本口腔外科学会総会・学術大会  2025.11.15 

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  • 上顎前突症を伴う全身性強皮症にみられた閉唇障害に対して顎矯正手術を適応した1例

    中辻和樹, 天野克比古, 明石翔, 永田裕樹, 古澤海風, 小竹森未菜美, 飯田征二

    第70回日本口腔外科学会総会・学術大会  2025.11.14 

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  • 神経線維腫症2型に関連して発症した下唇神経鞘腫の1例

    兵藤藍子, 天野克比古, 有村友紀, 高畠清文, 中辻和樹, 明石翔, 永田裕樹, 舩橋洋志, 石田修一, 飯田征二

    第70回日本口腔外科学会総会・学術大会  2025.11.14 

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  • 確定診断が得られず再発を繰り返した下顎骨内病変に発症した粘表皮癌の1例

    西田綾音, 武田斉子, 石田修一, 田村庄平, 德重侑, 明石翔, 天野克比古, 高畠清文, 中野敬介, 長塚仁, 竹下洋平, 柳文修, 飯田征二

    第72回NPO法人口腔内科学会中国・四国地方部会  2025.10.4 

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  • 下顎頭劣形成症に対して鳥貌改善を目的としてオトガイ部骨延長術を応用した1例

    明石 翔, 中辻 和樹, 有村 友紀, 永田 裕樹, 天野 克比古, 竹本 史子, 河野 加奈, 上岡 寛, 飯田 征二

    第35回日本顎変形症学会総会・学術大会  2025.6.6 

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    Presentation type:Poster presentation  

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  • 過度のSpeeの彎曲を有する下顎前突症に対してKole法を先行しLe Fort I型骨切り術/オトガイ形成術を2期的に適応した一例

    中辻 和樹, 天野 克比古, 谷崎 沙織, 有村 友紀, 明石 翔, 永田 裕樹, 植田 紘貴, 上岡 寛, 飯田 征二

    第35回日本顎変形症学会総会・学術大会  2025.6.5 

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  • 口腔内に多発性腫瘤を生じた多中心性細網組織球症の1例

    明石翔, 松村達志, 吉岡洋祐, 澤木康一, 中野誠, 天野克比古, 飯田征二

    第79回日本口腔科学会学術集会  2025.5.17 

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  • 上顎骨延長術後の口腔ケアの重要性について

    有村 友紀, 天野 克比古, 武田 斉子, 田村 庄平, 中辻 和樹, 明石 翔, 兵藤 藍子, 三上 彩可, 飯田 征二

    第22回日本口腔ケア学会総会・学術大会  2025.4.27 

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  • Importance of oral care in the postoperative stage of maxillary distraction osteogenesis

    Arimura Yuki, Amano Katsuhiko, Takeda Seiko, Tamura Shohei, Nakatsuji Kazuki, Akashi Sho, Hyodo Aiko, Mikami Ayaka, Iida Seiji

    The 5th Annual Meeting of the International Society of Oral Care  2025.4.27 

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  • A study of MRONJ cases in our department and their relationship to the number of remaining teeth

    Tamura Shohei, Amano Katsuhiko, Takeda Seiko, Arimura Yuki, Akashi Sho, Nagata Yuki, Funahashi Hiroshi, Furusawa Kaishi, Iida Seiji

    The 5th Annual Meeting of the International Society of Oral Care  2025.4.27 

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  • 当科でのMRONJ症例とその残存歯数の関係性についての検討

    田村 庄平, 天野 克比古, 武田 斉子, 有村 友紀, 明石 翔, 永田 裕樹, 舩橋 洋志, 古澤 海風, 飯田 征二

    第22回日本口腔ケア学会総会・学術大会  2025.4.26 

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    Presentation type:Oral presentation (general)  

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  • 下顎孔伝達麻酔後に生じたKuhnの貧血帯の一例 CT画像解析による原因の検討

    中野 誠, 天野 克比古, 澤木 康一, 吉岡 洋祐, 明石 翔, 佐藤 亜希, 飯田 征二

    第69回日本口腔外科学会総会・学術大会  2024.11 

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  • A case report of Cemento-ossifying fibroma and odontoma associated with Sturge–Weber syndrome in the jaw

    Furusho A., Sato A., Matsumura T., Nakano M., Sawaki K., Yoshioka Y., Akashi S., Mizukawa N., Kakimoto N., Miyauchi M.

    2023.8 

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  • 症状改善のため口腔衛生管理を行ったAIDS患者の一例

    三島久美, 澤木康一, 吉岡洋祐, 明石翔, 若松和子, 北山美穂, 中村真弓, 炭本有希

    第20回日本口腔ケア学会総会・学術大会  2023.4 

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  • 上顎に若年性砂粒腫様骨形成線維腫を伴った下顎巨大歯牙腫の1例

    佐藤亜希, 松村達志, 中野誠, 澤木康一, 吉岡洋祐, 明石翔, 古庄寿子, 宮内睦美, 水川展吉, 飯田征二

    第67回日本口腔外科学会総会・学術大会  2022.11 

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  • 上顎骨病変

    古庄寿子, 佐藤亜希, 松村達志, 中野誠, 澤木康一, 吉岡洋祐, 明石翔, 水川展吉, 飯田征二, 柿本直也, 宮内睦美

    3学会合同学術大会(第32回日本口腔内科学会・第33回日本臨床口腔病理学会・第35回日本口腔診断学会)  2022.9 

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  • 下唇に転移したバレット食道腺癌の1例

    明石翔, 吉岡洋祐, 澤木康一, 中野誠

    3学会合同学術大会(第32回日本口腔内科学会・第33回日本臨床口腔病理学会・第35回日本口腔診断学会)  2022.9 

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  • 当院における手術前周術期口腔機能管理対象患者の現状報告

    北山美穂, 澤木康一, 吉岡洋祐, 明石翔, 若松和子, 三島久美, 中村真弓, 炭本有希

    第19回日本口腔ケア学会総会・学術大会  2022.4 

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  • 保護床を装着したまま転院してしまった症例に対する検討とリスク管理再構築について

    若松和子, 吉岡洋祐, 明石翔, 北山美穂, 三島久美, 中村真弓, 炭本有希, 澤木康一

    第19回日本口腔ケア学会総会・学術大会  2022.4 

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  • 市中病院における口腔ケア 最少の人数で最大の効果を! 当院における周術期口腔機能管理の取り組み

    若松和子, 吉岡洋祐, 明石翔, 北山美穂, 三島久美, 中村真弓, 炭本有希, 澤木康一

    第19回日本口腔ケア学会総会・学術大会  2022.4 

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  • 軟骨細胞におけるRFX1を介したCCN3の発現制御機構の解明

    水川朋美, 西田崇, 明石翔, 河田かずみ, 菊池菫, 川木晴美, 滝川正春, 上岡寛, 久保田聡

    第94回日本生化学大会  2021.11 

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  • フッ化ナトリウムによるCCNファミリー遺伝子制御を介した歯肉線維化抑制作用の検討

    水川朋美, 西田崇, 明石翔, 大杉綾花, 大森一弘, 中山真彰, 高柴正悟, 上岡寛, 滝川正春, 久保田聡

    第42回岡山歯学会総会・学術集会  2021.11 

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  • 解糖阻害剤NaFによるCCNファミリー遺伝子の制御を介した歯肉線維化抑制効果の検討

    水川朋美, 西田崇, 明石翔, 堀綾花, 高柴正悟, 上岡寛, 滝川正春, 久保田聡

    第62回日本生化学会中国・四国支部例会  2021.9 

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  • 軟骨細胞でのRFX1によるCCNファミリータンパク質3遺伝子制御メカニズム

    水川朋美, 西田崇, 明石翔, 河田かずみ, 菊池菫, 川木晴美, 滝川正春, 上岡寛, 久保田聡

    第12回日本CCNファミリー研究会  2021.9 

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  • Effect of Episil® oral liquid on eating and swallowing function in patients with oral ulcer during cancer chemotherapy

    Yoshioka Y., Sawaki K., Akashi S., Nakano M.

    2nd World Dysphasia Summit  2021.8 

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  • 軟骨細胞における解糖系によるCCN3遺伝子発現制御メカニズム

    水川朋美, 西田崇, 明石翔, 上岡寛, 滝川正春, 久保田聡

    第33回日本軟骨代謝学会  2021.3 

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