Faculty Profiles - SAKAMOTO Shinji

Papers - SAKAMOTO Shinji

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Human Rho guanine nucleotide exchange factor 11 gene is associated with schizophrenia in a Japanese population Reviewed

Yutaka Mizuki, Manabu Takaki, Yuko Okahisa, Shinji Sakamoto, Masafumi Kodama, Hiroshi Ujike, Yosuke Uchitomi

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL 29 ( 6 ) 552 - 558 2014.11

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY

ObjectiveThe human Rho guanine nucleotide exchange factor 11 (ARHGEF11) gene is one of the candidate genes for type 2 diabetes mellitus (T2DM). ARHGEF11 is mapped to chromosome 1q21, which has susceptible risk loci for T2DM and schizophrenia. We hypothesized that ARHGEF11 contributes to the pathogenesis of schizophrenia.
MethodWe selected eight single nucleotide polymorphisms of ARHGEF11 that had significant associations with T2DM for a case-control association study of 490 patients with schizophrenia and 500 age-matched and sex-matched controls.
ResultsWe did not find any differences in allelic, genotypic associations, or minor allele frequencies with schizophrenia. Analysis of the rs6427340-rs6427339 haplotype and the rs822585-rs6427340-rs6427339 haplotype combination provided significant evidence of an association with schizophrenia (global permutations p=0.00047 and 0.0032, respectively). C-C of the rs6427340-rs6427339 haplotype and A-C-C of the rs822585-rs6427340-rs6427339 haplotype carried higher risk factors for schizophrenia (permutation p=0.0010 and 0.0018, respectively). A-C-T of the rs822585-rs6427340-rs6427339 haplotype had a possible protective effect (permutation p=0.031).
ConclusionThese results provide new evidence that ARHGEF11 may constitute a risk factor for schizophrenia. Copyright (c) 2014 John Wiley & Sons, Ltd.

DOI： 10.1002/hup.2435

Web of Science

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Four polymorphisms of the pericentriolar material 1 (PCM1) gene are not associated with schizophrenia in a Japanese population Reviewed

Sakamoto Shinji, Takaki Manabu, Okahisa Yuko, Mizuki Yutaka, Kodama Masafumi, Ujike Hiroshi, Uchitomi Yosuke

Psychiatry Research 216 ( 2 ) 288 - 289 2014.5

Association Study of Dopamine β-Hydroxylase Gene with Methamphetamine Psychosis． Reviewed

Okahisa Y, Ujike H, Takaki M, Mizuki Y, Sakamoto S, Won M, Kondo N, Naruse N, Aoyama-Uehara K, Iwata N, Iyo M, Sora I, Ozaki N, Uchitomi Y

Journal of Drug and Alcohol Research 3 1 - 6 2014.4

Adjunctive yokukansan treatment improved cognitive functions in a patient with schizophrenia. Reviewed International journal

Shinji Sakamoto, Hiroshi Ujike, Manabu Takaki, Yutaka Mizuki, Yuko Okahisa, Masafumi Kodama, Yosuke Uchitomi

The Journal of neuropsychiatry and clinical neurosciences 25 ( 3 ) E39-40 2013

Efficacy and tolerability of blonanserin in 48 patients with intractable schizophrenia. Reviewed International journal

Manabu Takaki, Yuko Okahisa, Masafumi Kodama, Yutaka Mizuki, Shinji Sakamoto, Hiroshi Ujike, Yosuke Uchitomi

Acta neuropsychiatrica 24 ( 6 ) 380 - 3 2012.12

Association between the tyrosine hydroxylase gene and patients with methamphetamine dependence

Y. Okahisa, M. Kishimoto, S. Sakamoto, Y. Mizuki, M. Takaki, M. Kodama, H. Ujike, Y. Uchitomi

EUROPEAN NEUROPSYCHOPHARMACOLOGY 22 S401 - S402 2012.10

Association between the fyn kinase gene and patients with methamphetamine psychosis

Y. Okahisa, S. Sakamoto, M. Kodama, M. Takaki, Y. Mizuki, H. Ujike, Y. Uchitomi

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 15 74 - 74 2012.6

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