研究者詳細 - 本田　知之

論文 - 本田　知之

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High-level Elevation of Transgene Expression via the Joint Effect of Trichostatin A and D-glucose in a Malignant Pleural Mesothelioma-derived Cell Line Resistant to Adenovirus Vector-based Transgene Expression. 査読

Mori J, Arao Y, Honda T, Kumon H

Journal of Cancer Science & Therapy 16 627 2024年4月

Suppression of Borna Disease Virus Replication during Its Persistent Infection Using the CRISPR/Cas13b System. 査読国際誌

Shigenori Sasaki, Hirohito Ogawa, Hirokazu Katoh, Tomoyuki Honda

International journal of molecular sciences 25 ( 6 ) 2024年3月

HAND2 suppresses favipiravir efficacy in treatment of Borna disease virus infection 査読

Da Teng, Keiji Ueda, Tomoyuki Honda

Antiviral Research 222 105812 - 105812 2024年2月

SARS-CoV-2 spike receptor-binding domain is internalized and promotes protein ISGylation in human induced pluripotent stem cell-derived cardiomyocytes 査読

Shota Okuno, Shuichiro Higo, Takumi Kondo, Mikio Shiba, Satoshi Kameda, Hiroyuki Inoue, Tomoka Tabata, Shou Ogawa, Yu Morishita, Congcong Sun, Saki Ishino, Tomoyuki Honda, Shigeru Miyagawa, Yasushi Sakata

Scientific Reports 13 ( 1 ) 2023年12月

Roles of Human Endogenous Retroviruses and Endogenous Virus-Like Elements in Cancer Development and Innate Immunity 査読

Hirokazu Katoh, Tomoyuki Honda

Biomolecules 13 ( 12 ) 1706 - 1706 2023年11月

Impact of Borna Disease Virus Infection on the Transcriptome of Differentiated Neuronal Cells and Its Modulation by Antiviral Treatment

Da Teng, Keiji Ueda, Tomoyuki Honda

Viruses 15 ( 4 ) 942 - 942 2023年4月

Need for re-evaluating the risk of coronavirus disease 2019 transmission to neonates. 査読国際誌

Kazuhiro Uda, Mitsuru Tsuge, Masato Yashiro, Tomoyuki Honda, Hirokazu Tsukahara

Pediatrics international : official journal of the Japan Pediatric Society 65 ( 1 ) e15460 2023年1月

Ribavirin Treatment for Severe Schizophrenia with Anti-Borna Disease Virus 1 Antibodies 30 Years after Onset. 査読国際誌

Hidenori Matsunaga, Akio Fukumori, Kohji Mori, Takashi Morihara, Shunsuke Sato, Kyoko Kitauchi, Kanta Yanagida, Kazumi Taguchi, Tomoyuki Honda, Keizo Tomonaga

Case reports in psychiatry 2023 4899364 - 4899364 2023年

記述言語：英語

OBJECTIVE: Borna disease virus 1 (BoDV-1) was proven to cause fatal encephalitis in humans in 2018. However, the effects of persistent infections remain unclear. Here, we present the case of a 50-year-old woman with a 30-year history of severe schizophrenia, who was exposed to fleas from stray cats prior to disease onset, suggesting the possibility of zoonosis including BoDV-1 infection. The patient had experienced significant social impairment, thought deterioration, delusions, and hallucinations for more than 20 years. METHOD: A radioligand assay was used to test the patient for IgG and IgM antibodies against BoDV-1 nucleoprotein (N) and phosphoprotein (P). Based on the protocol for hepatitis C, we treated the patient with 400 mg/day ribavirin, which was later increased to 600 mg/day. RESULTS: The serological examination revealed anti-BoDV-1 N IgG. Although only subtle changes were observed over the 24 weeks of treatment, the family noticed that the patient's Cotard delusions had disappeared 7 months after completing the treatment, accompanied by some improvements in the relationship with the family. CONCLUSION: Though definite proof was not obtained, this presumed suppression of BoDV-1 by ribavirin leading to improvements in Cotard syndrome-like symptoms suggests that intractable schizophrenia might be one of the BoDV-1 infection phenotypes. Further studies are needed to clarify the effect of persistent BoDV-1 infections in humans.

DOI： 10.1155/2023/4899364

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Cap Analysis of Gene Expression Clarifies Transcriptomic Divergence Within Monozygotic Twin Pairs. 査読

Hirokazu Katoh, Hiroaki Asai, Keiko Takemoto, Rie Tomizawa, Chika Honda, Mikio Watanabe, Osaka Twin, Researrch Group, Tomoyuki Honda

Twin Research and Human Genetics 1 - 8 2023年

RSウイルス感染症の全国サーベイランスとGoogle Trendsの相関性に関する検討

宇田和宏, 萩谷英大, 頼藤貴志, 小山敏広, 茂原研司, 津下充, 八代将登, 本田知之, 塚原宏一

日本小児感染症学会総会・学術集会プログラム・抄録集 54回 194 - 194 2022年11月

Viral Sequences Are Repurposed for Controlling Antiviral Responses as Non-Retroviral Endogenous Viral Elements. 招待査読

Hirohito Ogawa, Tomoyuki Honda

Acta medica Okayama 76 ( 5 ) 503 - 510 2022年10月

Waning of Anti-SARS-CoV-2 Spike Antibody Levels 100 to 200 Days after the Second Dose of the BNT162b2 Vaccine. 査読国際誌

Hidenori Matsunaga, Hidefumi Takeuchi, Yuichiro Oba, Satoshi Fujimi, Tomoyuki Honda, Keizo Tomonaga

Vaccines 10 ( 2 ) 2022年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

Anti-SARS-CoV-2 antibodies of 444 vaccinated hospital employees in Japan were measured 94-109 days and 199-212 days after receiving the second BNT162b2 vaccine dose to evaluate the intensity and duration of antibody response in our own cohort. Among uninfected participants, anti-S antibody levels were greatly decreased 199-212 days after the second vaccination compared to the levels measured 94-109 days after the second vaccination (median levels: 830 AU/mL and 2425 AU/mL, respectively; p < 0.001). The rate of decrease between the two testing periods was lower in infected participants than in uninfected participants (median: 47.7% and 33.9%, respectively; p < 0.001). Anti-S antibody levels were significantly higher in females (median: females, 2546 AU/mL; males, 2041 AU/mL; p = 0.002 during the first test period). The peak body temperature after vaccination was higher in females than in males (median: females, 37.4 °C; males: 37.1 °C; p = 0.044). Older males tended to have lower antibody levels. In conclusion, the duration of the anti-S antibody response to the BNT162b2 vaccine was short-lived, particularly in males. Anti-S antibody levels of 1000 AU/mL or lower according to SARS-CoV-2 IgG II Quant (Abbott) might indicate insufficient prevention against the delta variant, and the majority of participants appeared to have lost their protection 200 days after vaccination.

DOI： 10.3390/vaccines10020177

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Nectin-2 Acts as a Viral Entry Mediated Molecule That Binds to Human Herpesvirus 6B Glycoprotein B 査読

Hirohito Ogawa, Daisuke Fujikura, Hikaru Namba, Nobuko Yamashita, Tomoyuki Honda, Masao Yamada

Viruses 14 ( 1 ) 160 - 160 2022年1月

「抗ボルナウイルス抗体陽性で難治の精神神経症状をもつ症例に対するリバビリン治療」を行った一例

松永秀典, 陸馨仙, 北内京子, 福本裕美, 本田知之, 福森亮雄, 朝長啓造

NEUROINFECTION 26 ( 2 ) 56 - 56 2021年9月

A patient with human coronavirus NL63 falsely diagnosed with COVID-19; Lesson learned for the importance of definitive diagnosis 査読国際誌

Yuki Otsuka, Hideharu Hagiya, Yasuhiro Nakano, Daisuke Omura, Kou Hasegawa, Haruto Yamada, Koji Iio, Tomoyuki Honda, Fumio Otsuka

Journal of Infection and Chemotherapy 27 ( 7 ) 1126 - 1128 2021年7月

A Human Endogenous Bornavirus-Like Nucleoprotein Encodes a Mitochondrial Protein Associated with Cell Viability 査読

Kan Fujino, Masayuki Horie, Shohei Kojima, Sae Shimizu, Aya Nabekura, Hiroko Kobayashi, Akiko Makino, Tomoyuki Honda, Keizo Tomonaga

Journal of Virology 95 ( 14 ) 2021年6月

Characterization of an active LINE-1 in the naked mole-rat genome. 査読国際誌

Shunichi Yamaguchi, Shizuka Nohara, Yuki Nishikawa, Yusuke Suzuki, Yoshimi Kawamura, Kyoko Miura, Keizo Tomonaga, Keiji Ueda, Tomoyuki Honda

Scientific reports 11 ( 1 ) 5725 - 5725 2021年3月

担当区分：最終著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-living rodent species. A reason for their long lifespan is pronounced cancer resistance. Therefore, researchers believe that NMRs have unknown secrets of cancer resistance and seek to find them. Here, to reveal the secrets, we noticed a retrotransposon, long interspersed nuclear element 1 (L1). L1s can amplify themselves and are considered endogenous oncogenic mutagens. Since the NMR genome contains fewer L1-derived sequences than other mammalian genomes, we reasoned that the retrotransposition activity of L1s in the NMR genome is lower than those in other mammalian genomes. In this study, we successfully cloned an intact L1 from the NMR genome and named it NMR-L1. An L1 retrotransposition assay using the NMR-L1 reporter revealed that NMR-L1 was active retrotransposon, but its activity was lower than that of human and mouse L1s. Despite lower retrotrasposition activity, NMR-L1 was still capable of inducing cell senescence, a tumor-protective system. NMR-L1 required the 3' untranslated region (UTR) for retrotransposition, suggesting that NMR-L1 is a stringent-type of L1. We also confirmed the 5' UTR promoter activity of NMR-L1. Finally, we identified the G-quadruplex structure of the 3' UTR, which modulated the retrotransposition activity of NMR-L1. Taken together, the data indicate that NMR-L1 retrotranspose less efficiently, which may contribute to the cancer resistance of NMRs.

DOI： 10.1038/s41598-021-84962-8

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Radioligand Assay-Based Detection of Antibodies against SARS-CoV-2 in Hospital Workers Treating Patients with Severe COVID-19 in Japan. 査読国際誌

Hidenori Matsunaga, Akiko Makino, Yasuhiro Kato, Teruaki Murakami, Yuta Yamaguchi, Atsushi Kumanogoh, Yuichiro Oba, Satoshi Fujimi, Tomoyuki Honda, Keizo Tomonaga

Viruses 13 ( 2 ) 2021年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

This study aimed to clarify whether infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is prevalent among the staff of a hospital providing treatment to patients with severe coronavirus disease 2019 (COVID-19) using radioligand assay (RLA). One thousand samples from the staff of a general hospital providing treatment to patients with severe COVID-19 were assayed for SARS-CoV-2 nucleocapsid protein (N) IgG using RLA. Nine patients with COVID-19 who had been treated in inpatient settings and had already recovered were used as control subjects, and 186 blood donor samples obtained more than 10 years ago were used as negative controls. Four of the 1000 samples showed apparently positive results, and approximately 10 or more samples showed slightly high counts. Interestingly, a few among the blood donor samples also showed slightly high values. To validate the results, antibody examinations using ELISA and neutralizing antibody tests were performed on 21 samples, and chemiluminescence immunoassay (CLIA) was performed on 201 samples, both resulting in a very high correlation. One blood donor sample showed slightly positive results in both RLA and CLIA, suggesting a cross-reaction. This study showed that five months after the pandemic began in Japan, the staff of a general hospital with a tertiary emergency medical facility had an extremely low seroprevalence of the antibodies against SARS-CoV-2. Further investigation will be needed to determine whether the slightly high results were due to cross-reactions or a low titer of anti-SARS-CoV-2 antibodies. The quantitative RLA was considered sensitive enough to detect low titers of antibodies.

DOI： 10.3390/v13020347

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A traditional Chinese medicine, maoto, suppresses hepatitis B virus production 査読国際誌

Md Arifur Rahman, Keiji Ueda, Tomoyuki Honda

Frontiers in Cellular and Infection Microbiology in press 581345 - 581345 2020年12月

Effects of activation of the LINE‐1 antisense promoter on the growth of cultured cells 査読

Tomoyuki Honda, Yuki Nishikawa, Kensuke Nishimura, Da Teng, Keiko Takemoto, Keiji Ueda

Scientific Reports 10 ( 1 ) in press 2020年12月

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