Updated on 2025/04/02

写真a

 
Nakayama Rie
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Special-Appointment Assistant Professor
Position
Special-Appointment Assistant Professor
External link
 

Papers

  • Crescent-Shaped Atrial Septal Defect: A New Clinical Entity of an Acquired Defect for Transcatheter Closure. International journal

    Mitsutaka Nakashima, Teiji Akagi, Yoichi Takaya, Takashi Miki, Rie Nakayama, Koji Nakagawa, Norihisa Toh, Kazufumi Nakamura, Shinsuke Yuasa

    JACC. Asia   4 ( 12 )   1013 - 1016   2024.12

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    DOI: 10.1016/j.jacasi.2024.09.006

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  • Prognostic value of right atrial function in patients with significant tricuspid regurgitation. International journal

    Takahiro Nishihara, Yoichi Takaya, Rie Nakayama, Yu Yoshida, Norihisa Toh, Toru Miyoshi, Kazufumi Nakamura, Shinsuke Yuasa

    ESC heart failure   2024.8

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    AIMS: Although right ventricular (RV) dysfunction is associated with adverse outcomes in tricuspid regurgitation (TR), the potential role of right atrial (RA) function is unknown. We aimed to investigate the relationship between RA function and clinical outcomes in patients with significant TR. METHODS: This retrospective study included 169 outpatients with moderate or severe TR due to left-sided heart diseases who underwent transthoracic echocardiography between June 2020 and April 2023 (average age, 75 ± 10 years; male, 40%). Patients with atrial fibrillation were excluded from this study due to the inaccuracy of the evaluation using 2D speckle-tracking echocardiography. RA function was compared between patients with and without events, which were defined as all-cause mortality or hospitalization due to heart failure. RA function was calculated as RA global longitudinal strain (RAGLS) with the 2D speckle-tracking echocardiography. RESULTS: During a median follow-up of 13 months, 19 patients had events (all-cause mortality: 14 cases, hospitalization due to heart failure: 5 cases). RAGLS was lower in patients with events than in those without events (13% ± 10% vs. 18% ± 9%, P = 0.02). When the patients were categorized into two groups [low RAGLS ≤ 16.2% vs. high RAGLS > 16.2%, high RA volume index (RAVI) ≥ 50 mL/m2 vs. low RAVI < 50 mL/m2], Kaplan-Meier curves showed that patients with low RAGLS had higher event rates than those with high RAGLS (log-rank test, P = 0.003). Patients with high RAVI had higher event rates than those with low RAVI (log-rank test, P < 0.001). In the multivariate Cox regression analysis, low RAGLS (≤16.2%) was significantly associated with events in a model that included RV dysfunction (RV fractional area change ≤ 35%) or high RAVI (≥50 mL/m2) (hazard ratio: 4.55, 95% confidence interval: 1.51-13.71, P < 0.01; hazard ratio: 4.57, 95% confidence interval: 1.52-13.79, P < 0.01, respectively). CONCLUSIONS: RAGLS is associated with all-cause mortality and hospitalization due to heart failure in patients with significant TR. Our results suggest that RA function is a sensitive marker for identifying the risk stratification of significant TR.

    DOI: 10.1002/ehf2.14846

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  • Fenestrated GORE® CARDIOFORM ASD occluder for transcatheter atrial septal defect closure in a geriatric patient.

    Mitsutaka Nakashima, Teiji Akagi, Takashi Miki, Rie Nakayama, Yoichi Takaya, Koji Nakagawa, Satoshi Akagi, Norihisa Toh, Kazufumi Nakamura

    Journal of cardiology cases   30 ( 2 )   31 - 34   2024.8

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    UNLABELLED: An 82-year-old man with a secundum atrial septal defect (ASD) underwent transcatheter closure. The patient had a wide area of aortic and superior rim deficiency, with left ventricular diastolic dysfunction and moderate mitral regurgitation. These findings suggested the risk of both cardiac erosion and increased left atrial pressure after closure. To avoid cardiac erosion, a GORE® CARDIOFORM ASD (GCA) occluder (W.L. Gore & Associates, Flagstaff, AZ, USA) was considered an appropriate device in this patient. However, the possibility of excessively high left atrial pressure due to complete defect closure was a concern. Thus, we created a 4.5-mm fenestration using a surgical punch in the fabric membrane of a 44-mm GCA. The device was deployed in an appropriate position, and no significant elevation of pulmonary capillary wedge pressure was observed. One month after the closure, marked improvement in clinical symptoms and continuous flow through the fenestration were observed. This novel fenestration technique may contribute to expansion of the indications for transcatheter ASD closure in patients who require a GCA owing to an anatomically high risk of erosion accompanied by left ventricular diastolic dysfunction. LEARNING OBJECTIVE: In elderly patients with left ventricular diastolic dysfunction, transcatheter atrial septal defect (ASD) closure is difficult because rapid resolution of an ASD shunt can cause an increase in left atrial pressure. Previous reports described the creation of a fenestration in the closure device. The use of a GORE® CARDIOFORM ASD (GCA) occluder can reduce the erosion risk; however, creating a stable fenestration is difficult. We developed a novel technique to create a stable fenestration in a GCA.

    DOI: 10.1016/j.jccase.2024.04.001

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  • Reply to the letter, "Residual shunt after patent foramen ovale closure: The devil is in the details!" regarding article "Relationship between patent foramen ovale anatomical features and residual shunt after patent foramen ovale closure". International journal

    Rie Nakayama, Yoichi Takaya, Teiji Akagi, Rika Takemoto, Madoka Haruna, Mitsutaka Nakashima, Takashi Miki, Koji Nakagawa, Norihisa Toh, Kazufumi Nakamura, Shinsuke Yuasa

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions   2024.7

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    DOI: 10.1002/ccd.31163

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  • Relationship between patent foramen ovale anatomical features and residual shunt after patent foramen ovale closure.

    Rie Nakayama, Yoichi Takaya, Teiji Akagi, Rika Takemoto, Madoka Haruna, Mitsutaka Nakashima, Takashi Miki, Koji Nakagawa, Norihisa Toh, Kazufumi Nakamura

    Cardiovascular intervention and therapeutics   39 ( 2 )   200 - 206   2024.4

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    Transcatheter closure of patent foramen ovale (PFO) is an effective strategy for preventing recurrence of paradoxical embolism. However, PFO closure is often associated with residual shunt, which is a risk of recurrent stroke. This study aimed to evaluate the relationship between the anatomical features of PFO and residual shunt. The degree of residual shunt and its relationship with the anatomical features of PFO were evaluated in 106 patients who underwent PFO closure at our institution between March 2011 and January 2022 and in whom contrast transthoracic echocardiography was performed 1 year later. The mean PFO tunnel length was 9.3 ± 3.6 mm and the mean PFO height was 3.2 ± 2.2 mm. Atrial septal aneurysm (ASA) was found in 37 patients. After PFO closure, residual shunt was observed in 28 patients (grade 1, n = 8; grade 2, n = 16; grade 3, n = 3; grade 4, n = 1). Univariate logistic analysis identified ASA to be associated with residual shunt (odds ratio 2.78, 95% confidence interval 1.14 to 6.79; p = 0.024). There was no association of residual shunt with the size of the PFO, the length of PFO tunnel, or the size of the device used for closure. Two of four patients with a large residual shunt of grade 3 or grade 4 were found to have device size mismatch. Residual shunt after PFO closure was observed in a quarter of patients and was related to the presence of ASA. A few patients had a large residual shunt due to the device size mismatch.

    DOI: 10.1007/s12928-023-00979-y

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  • Prevalence of Iron Deficiency and Its Association with Exercise Capacity in Adult Fontan Patients(タイトル和訳中)

    中島 充貴, 杜 徳尚, 赤木 禎治, 中山 理絵, 三木 崇史, 高谷 陽一, 赤木 達, 中川 晃志, 西井 伸洋, 中村 一文

    日本循環器学会学術集会抄録集   88回   PJ027 - 2   2024.3

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  • 出産を契機に肺高血圧症と診断されTreat & Repair療法に成功したASD症例

    古田 めぐみ, 中島 充貴, 赤木 禎治, 三木 崇史, 中山 理絵, 高谷 陽一, 中川 晃志, 赤木 達, 杜 徳尚, 西井 伸洋, 中村 一文, 松原 広己

    日本成人先天性心疾患学会雑誌   13 ( 1 )   143 - 143   2024.1

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  • GORE CARDIOFORM Septal Occluderを用いた経皮的卵円孔開存閉鎖術の国内初期成績

    中島 充貴, 赤木 禎治, 三木 崇史, 中山 理絵, 高谷 陽一, 中川 晃志, 杜 徳尚, 中村 一文

    日本心臓病学会学術集会抄録   71回   O - 1   2023.9

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  • 奇異性脳塞栓症を起こした卵円孔開存は心臓CTでどのように見えるのか?

    三木 崇史, 中川 晃志, 辻 真弘, 中島 充貴, 西原 大裕, 中山 理絵, 高谷 陽一, 三好 亨, 赤木 禎治, 伊藤 浩

    日本心血管インターベンション治療学会抄録集   31回   MO66 - 5   2023.8

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  • Association of perivascular fat attenuation on computed tomography and heart failure with preserved ejection fraction. International journal

    Takahiro Nishihara, Toru Miyoshi, Mitsutaka Nakashima, Keishi Ichikawa, Yoichi Takaya, Rie Nakayama, Takashi Miki, Hiroshi Ito

    ESC heart failure   10 ( 4 )   2447 - 2457   2023.8

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    AIMS: Heart failure with a preserved ejection fraction (HFpEF) is associated with chronic inflammation. We aimed to investigate the association between pericoronary adipose tissue attenuation (PCATA) on coronary computed tomography angiography as a novel noninvasive marker of pericoronary inflammation and the presence of HFpEF. METHODS AND RESULTS: This retrospective study included 607 outpatients (median age, 65 years; 50% male) who underwent both echocardiography and coronary computed tomography angiography. Patients with obstructive coronary artery disease were excluded from this study. PCATA was compared between patients with and without HFpEF, which was diagnosed according to the Heart Failure Association (HFA)-PEFF score. PCATA was assessed at the proximal 40-mm segments of all three major coronary arteries on coronary computed tomography angiography. Patients with HFpEF had higher PCATA in all coronary arteries compared to the control participants: left anterior descending artery (LAD), -65.2 ± 6.9 Hounsfield units (HU) vs. -68.1 ± 6.7 HU; left circumflex artery (LCX), -62.7 ± 6.8 HU vs. -65.4 ± 6.6 HU; and right coronary artery (RCA), -63.6 ± 8.5 HU vs. -65.5 ± 7.7 HU (P < 0.01). Multivariate logistic regression analysis, including conventional risk factors, revealed that PCATA per standard deviation in the LAD (odds ratio [OR], 1.449; 95% confidence interval [CI], 1.152-1.823), LCX (OR, 1.634; 95% CI, 1.283-2.081), and RCA (OR, 1.388; 95% CI, 1.107-1.740) were independently associated with HFpEF. The association between PCATA and HFpEF was mostly consistent across various patient clinical characteristics. The left ventricular mass and left atrial volume index showed a mild correlation with LAD-PCATA (ρ = 0.13 [P < 0.01] and ρ = 0.24 [P < 0.01]) and LCX-PCATA (ρ = 0.16 [P < 0.01] and ρ = 0.23 [P < 0.01]). CONCLUSIONS: High PCATA score was significantly associated with the presence of HFpEF. Our results suggest that inflammation in the pericoronary artery adipose tissue is one of the underlying mechanisms of HFpEF.

    DOI: 10.1002/ehf2.14419

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  • Diagnostic Performance of Cardiac Computed Tomography for Detecting Patent Foramen Ovale: Evaluation Using Transesophageal Echocardiography and Catheterization as Reference Standards. International journal

    Takashi Miki, Koji Nakagawa, Keishi Ichikawa, Tomofumi Mizuno, Rie Nakayama, Kentaro Ejiri, Satoshi Kawada, Yoichi Takaya, Masakazu Miyamoto, Toru Miyoshi, Teiji Akagi, Hiroshi Ito

    Journal of cardiovascular development and disease   10 ( 5 )   2023.4

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    BACKGROUND: Patent foramen ovale (PFO) is associated with various diseases such as cryptogenic stroke, migraine, and platypnea-orthodeoxia syndrome. This study aimed to evaluate the diagnostic performance of cardiac computed tomography (CT) for PFO detection. MATERIALS AND METHODS: Consecutive patients diagnosed with atrial fibrillation and who underwent catheter ablation with pre-procedural cardiac CT and transesophageal echocardiography (TEE) were enrolled in this study. The presence of PFO was defined as (1) the confirmation of PFO using TEE and/or (2) the catheter crossing the interatrial septum (IAS) into the left atrium during ablation. CT findings indicative of PFO included (1) the presence of a channel-like appearance (CLA) on the IAS and (2) a CLA with a contrast jet flow from the left atrium to the right atrium. The diagnostic performance of both a CLA alone and a CLA with a jet flow was evaluated for PFO detection. RESULTS: Altogether, 151 patients were analyzed in the study (mean age, 68 years; men, 62%). Twenty-nine patients (19%) had PFO confirmed by TEE and/or catheterization. The diagnostic performance of a CLA alone was as follows: sensitivity, 72.4%; specificity, 79.5%; positive predictive value (PPV), 45.7%; negative predictive value (NPV), 92.4%. The diagnostic performance of a CLA with a jet flow was as follows: sensitivity, 65.5%; specificity, 98.4%; PPV, 90.5%; NPV, 92.3%. The diagnostic performance of a CLA with a jet flow was statistically superior to that of a CLA alone (p = 0.045), and the C-statistics were 0.76 and 0.82, respectively. CONCLUSION: A CLA with a contrast jet flow in cardiac CT has a high PPV for PFO detection, and its diagnostic performance is superior to that of a CLA alone.

    DOI: 10.3390/jcdd10050193

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  • Patent foramen ovale with sail-like Eustachian valve causing recurrent strokes.

    Rie Nakayama, Yoichi Takaya, Teiji Akagi, Fumi Yokohama, Takashi Miki, Hiroshi Ito

    Cardiovascular intervention and therapeutics   38 ( 2 )   264 - 265   2023.4

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    DOI: 10.1007/s12928-022-00887-7

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  • Shear Wave Dispersion Slope of the Liver Can Predict Adverse Outcomes in Patients with Pulmonary Hypertension.

    Chikara Urabe, Yoichi Takaya, Rie Nakayama, Kazufumi Nakamura, Hiroshi Ito

    International heart journal   64 ( 2 )   230 - 236   2023.3

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    Pulmonary hypertension (PH) often causes right-sided heart failure (HF), inducing organ damage. Shear wave elastography (SWE) is a novel ultrasound technique for characterizing tissue. Some studies have reported that shear wave dispersion slope (SWDS) enables the assessment of early hepatic damage in HF. This study aimed to evaluate the prognostic impact of SWDS in patients with PH.This single-center cohort study enrolled 36 patients with PH who underwent SWE at Okayama University Hospital between March 2018 and April 2021. Patients were divided into 2 groups on the basis of the median value of SWDS: low SWDS group (SWDS < 12.4 m/second/kHz, n = 18) and high SWDS group (SWDS ≥ 12.4 m/second/kHz, n = 18). The primary endpoint was the complex of all-cause death or hospitalization for HF. During the follow-up of 391 ± 288 days, all-cause death or hospitalization for HF occurred in 8 patients. One patient died in the low SWDS group. Three patients died and 4 patients were hospitalized for HF in the high group. Kaplan-Meier analysis revealed that the event-free survival rate was significantly worse in the high SWDS group than in the low SWDS group (log-rank, P = 0.01). In univariate Cox proportional hazards analysis, high SWDS was associated with the events (hazard ratio 10.8; 95% confidence interval 1.89-202, P = 0.005).An elevated SWDS was associated with a high rate of events in patients with PH. SWDS has the potential to predict adverse outcomes in patients with PH.

    DOI: 10.1536/ihj.22-574

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  • Morphological Features on Cardiac CT of Patent Foramen Ovale Causing Cryptogenic Stroke(タイトル和訳中)

    三木 崇史, 中川 晃志, 辻 真弘, 中島 充貴, 西原 大裕, 中山 理絵, 高谷 陽一, 三好 亨, 赤木 禎治, 伊藤 浩

    日本循環器学会学術集会抄録集   87回   PJ004 - 6   2023.3

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  • Association of Perivascular Fat Attenuation on Computed Tomography and Heart Failure with Preserved Ejection Fraction(タイトル和訳中)

    西原 大裕, 三好 亨, 中島 充貴, 中山 理絵, 三木 崇史, 高谷 陽一, 伊藤 浩

    日本循環器学会学術集会抄録集   87回   PJ113 - 6   2023.3

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  • Pulmonary arteriovenous fistula in a rare location: The importance of excluding patent foramen ovale.

    Mitsutaka Nakashima, Takashi Miki, Yoichi Takaya, Rie Nakayama, Koji Nakagawa, Satoshi Akagi, Norihisa Toh, Teiji Akagi, Hiroshi Ito

    Journal of cardiology cases   27 ( 3 )   124 - 127   2023.3

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    UNLABELLED: A 46-year-old woman with a history of repeated thromboembolic stroke and anti-phospholipid antibody syndrome was referred to our hospital. Saline contrast transthoracic echocardiography showed that microbubbles appeared in the left atrium within 4 heartbeats. Thus, she was initially suspected as having a patent foramen ovale with associated paradoxical embolism. However, no evidence of patent foramen ovale or atrial septal defect could be found using transesophageal echocardiography. Saline contrast transesophageal echocardiography showed that microbubbles flowed into the left atrium through the left superior pulmonary vein. Ultimately, she was diagnosed as having a pulmonary arteriovenous malformation located at the upper left pulmonary lobe using contrast computed tomography and pulmonary artery angiography. Pulmonary arteriovenous malformations are typically located in the lower lobe of either lung and, in bubble studies, contrast appears in the left atrium after 4 heartbeats. Here, the pulmonary arteriovenous malformation was in the upper lobe, and contrast appeared in the left atrium at an earlier time point: one associated with patent foramen ovale. These findings made it difficult to differentiate the two diseases initially. This case suggests that pulmonary arteriovenous malformation should be carefully considered, even if microbubbles appear in the left atrium early on a saline contrast transthoracic echocardiograph. LEARNING OBJECTIVE: Pulmonary arteriovenous malformation occasionally appears in the upper lobe. In these cases, microbubbles may appear in the left atrium after detection in the right atrium with a time-course that is suggestive of a patent foramen ovale. Therefore, diagnosis should be carefully confirmed by using other multimodal imaging tests, such as transesophageal echocardiography, contrast computed tomography, or pulmonary artery angiography.

    DOI: 10.1016/j.jccase.2022.11.005

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  • Association between Cardiovascular Disease and Liver Disease, from a Clinically Pragmatic Perspective as a Cardiologist. International journal

    Mitsutaka Nakashima, Kazufumi Nakamura, Takahiro Nishihara, Keishi Ichikawa, Rie Nakayama, Yoichi Takaya, Norihisa Toh, Satoshi Akagi, Toru Miyoshi, Teiji Akagi, Hiroshi Ito

    Nutrients   15 ( 3 )   2023.2

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    Cardiovascular diseases and liver diseases are closely related. Non-alcoholic fatty liver disease has the same risk factors as those for atherosclerotic cardiovascular disease and may also be a risk factor for atherosclerotic cardiovascular disease on its own. Heart failure causes liver fibrosis, and liver fibrosis results in worsened cardiac preload and congestion. Although some previous reports regard the association between cardiovascular diseases and liver disease, the management strategy for liver disease in patients with cardiovascular diseases is not still established. This review summarized the association between cardiovascular diseases and liver disease. In patients with non-alcoholic fatty liver disease, the degree of liver fibrosis progresses with worsening cardiovascular prognosis. In patients with heart failure, liver fibrosis could be a prognostic marker. Liver stiffness assessed with shear wave elastography, the fibrosis-4 index, and non-alcoholic fatty liver disease fibrosis score is associated with both liver fibrosis in patients with liver diseases and worse prognosis in patients with heart failure. With the current population ageing, the importance of management for cardiovascular diseases and liver disease has been increasing. However, whether management and interventions for liver disease improve the prognosis of cardiovascular diseases has not been fully understood. Future investigations are needed.

    DOI: 10.3390/nu15030748

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  • Temporary balloon occlusion test can overestimate the risk of acute pulmonary edema after transcatheter atrial septal defect closure. International journal

    Koji Nakagawa, Teiji Akagi, Yoichi Takaya, Takashi Miki, Yasufumi Kijima, Rie Nakayama, Norihisa Toh, Nobuhiro Nishii, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions   2023.1

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    BACKGROUND: Atrial septal defect (ASD) closure can cause acute pulmonary edema. Before transcatheter closure is performed, temporary balloon occlusion test (BOT) is recommended in patients with left ventricular dysfunction to predict the risk of pulmonary edema. However, the accuracy of BOT has not been verified. This study aimed to compare hemodynamic differences between BOT and transcatheter closure. METHODS: A total of 42 patients with a single ASD over age 18 years who underwent BOT before transcatheter ASD closure between October 2010 and May 2020 were analyzed. Pulmonary capillary wedge pressure (PCWP) was measured using a Swan-Ganz catheter placed in the pulmonary artery at baseline, after 10 min of BOT, and after transcatheter closure. Amplatzer septal occluder was used for all transcatheter closures. RESULTS: Mean patient age was 64 ± 18 years (range, 18-78). Mean ASD diameter and pulmonary to systemic flow ratio were 18 ± 5 and 2.8 ± 1.0 mm, respectively. Mean PCWP at baseline, during BOT, and after transcatheter closure was 8.9 ± 2.9, 13.5 ± 4.2, and 9.5 ± 2.6 mmHg, respectively. The difference between BOT and after transcatheter closure values was significant (p < 0.001). During BOT, PCWP increased ≥18 mmHg in 7 patients, whereas after ASD closure, PCWP was <18 mmHg in all 7 and none developed acute pulmonary edema. CONCLUSION: Temporary balloon occlusion of an ASD and transcatheter ASD closure result in different hemodynamic change. BOT overestimates increase of PCWP after transcatheter ASD closure and requires careful interpretation. Well-designed, larger studies in higher-risk patients are warranted to verify the clinical implications of BOT in more detail.

    DOI: 10.1002/ccd.30556

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  • 奇異性脳塞栓症を起こした卵円孔開存は心臓CTでどう見えるのか?

    三木 崇史, 中川 晃志, 辻 真弘, 中島 充貴, 西原 大裕, 中山 理絵, 高谷 陽一, 三好 亨, 赤木 禎治, 伊藤 浩

    日本成人先天性心疾患学会雑誌   12 ( 1 )   158 - 158   2023.1

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  • Efficacy of shear wave elasticity for predicting clinical outcomes in patients with significant tricuspid regurgitation.

    Rie Nakayama, Yoichi Takaya, Kazufumi Nakamura, Rika Takemoto, Norihisa Toh, Hiroshi Ito

    Heart and vessels   37 ( 11 )   1866 - 1872   2022.11

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    This study aimed to evaluate the efficacy of shear wave (SW) elasticity for assessing clinical outcomes in patients with significant tricuspid regurgitation (TR). Significant TR develops right heart failure (HF) with organ congestion, resulting in adverse outcomes, but appropriate therapeutic strategies remain unclear. The assessment of the degree of hepatic congestion using SW elasticity may be effective for determining therapeutic strategies. We prospectively enrolled 77 patients with moderate or severe TR who underwent SW elastography. Patients were divided into three groups according to the value of SW elasticity: low group (SW elasticity < 6.4 kPa, n = 26), medium group (6.4 ≤ SW elasticity < 9.5 kPa, n = 26), and high group (SW elasticity ≥ 9.5 kPa, n = 25). The endpoint was cardiovascular death or hospitalization for HF. During the median follow-up period of 17 months (range 7-39 months), cardiovascular death or hospitalization for HF occurred in seven patients of high group, in three patients of medium group, and in no patients of low group. In high group, three patients died and seven patients were hospitalized for HF. In medium group, two patients died and one patient was hospitalized. Kaplan-Meier analysis showed that the event-free survival rate was worse in high group than in other groups (log-rank test, p = 0.02). High SW elasticity was independently related to cardiac events as well as right ventricular and left ventricular dysfunction. SW elasticity was a predictor of cardiac events in patients with significant TR by assessing hepatic congestion. SW elasticity can be valuable for determining therapeutic strategies for TR.

    DOI: 10.1007/s00380-022-02084-1

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  • Utility of computed tomography findings as a predictor of carotid artery invasion by metastatic lymph nodes in head and neck squamous cell carcinoma. International journal

    Takuya Mikoshiba, Koji Sakamoto, Seiichi Shinden, Marie Shimanuki, Rie Nakayama, Takashi Okada, Hiroyuki Ozawa

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery   279 ( 9 )   4561 - 4568   2022.9

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    PURPOSE: Carotid artery invasion by metastatic lymph nodes in head and neck squamous cell carcinoma (HNSCC) is one of the diagnostic criteria for unresectable tumors. However, to date, the diagnostic criteria for carotid artery invasion have not been well documented. This study investigated the utility of computed tomography (CT) findings as a predictor of carotid artery invasion by metastatic lymph nodes in HNSCC. METHODS: Twenty-eight patients who had metastatic lymph nodes of HNSCC attached to the carotid artery as seen on CT images before neck dissection from January 2011 to November 2017 were included. Five imaging parameters (angle of contact [AC], length of contact [LC], haziness of the carotid artery wall [HW], size of the lymph node, and involvement of the bifurcation of the carotid artery [IB]) were assessed using CT to predict carotid artery invasion. Furthermore, the utility of the combination of these five parameters was evaluated. RESULTS: There were significant differences in AC, LC, and IB between patients with and without carotid artery invasion. There were significant differences in all combinations of the two image findings between patients with and without carotid artery invasion. In particular, the combinations of LC and HW, and LC and IB could clearly predict carotid artery invasion. CONCLUSION: AC, LC, and IB were useful predictors of carotid artery invasion of metastatic lymph nodes in HNSCC. This study is the first to report that IB is a useful predictor of carotid artery invasion in HNSCC.

    DOI: 10.1007/s00405-022-07393-9

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  • Overview of the 86th Annual Scientific Meeting of the Japanese Circulation Society - Cardiology Spreading Its Wings.

    Kazufumi Nakamura, Toru Miyoshi, Satoshi Akagi, Norihisa Toh, Yukihiro Saito, Yoichi Takaya, Masatoki Yoshida, Koji Nakagawa, Satoshi Kawada, Hironobu Toda, Takashi Miki, Rie Nakayama, Fumi Yokohama, Keishi Ichikawa, Masashi Yoshida, Makiko Taniyama, Nobuhiro Nishii, Teiji Akagi, Hiroshi Morita, Hiroshi Ito

    Circulation journal : official journal of the Japanese Circulation Society   86 ( 8 )   1312 - 1318   2022.7

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    The 86thAnnual Scientific Meeting of the Japanese Circulation Society was held in a web-based format on March 11-13, 2022. In accordance with the internationalization policy of the JCS, the meeting was held with the Asian Pacific Society of Cardiology Congress 2022. The main theme was "Cardiology Spreading its Wings". The number of patients with heart failure and other cardiovascular diseases is increasing dramatically, and the fields dealt with by cardiovascular medicine are also greatly expanding. This conference was both intellectually satisfying and exciting for all participants, who numbered over 14,900. The meeting was completed with great success, and the enormous amount of cooperation and support from all involved was greatly appreciated.

    DOI: 10.1253/circj.CJ-22-0349

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  • Impact of shear wave dispersion slope analysis for assessing the severity of myocarditis. International journal

    Naofumi Amioka, Yoichi Takaya, Kazufumi Nakamura, Megumi Kondo, Kaoru Akazawa, Yuko Ohno, Keishi Ichikawa, Rie Nakayama, Yukihiro Saito, Satoshi Akagi, Toru Miyoshi, Masashi Yoshida, Hiroshi Morita, Hiroshi Ito

    Scientific reports   12 ( 1 )   8776 - 8776   2022.5

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    This study aimed to elucidate the utility of a novel ultrasound-based technique, shear wave dispersion slope (SWDS) analysis, which estimates tissue viscosity, for evaluating the severity of myocardial inflammation. Experimental autoimmune myocarditis (EAM) at different disease phases [3-week (acute phase): n = 10, 5-week (subacute phase): n = 9, and 7-week (late phase): n = 11] were developed in male Lewis rats. SWDS was measured in the right and the left ventricular free walls (RVFW and LVFW) under a retrograde perfusion condition. Histological myocardial inflammation was evaluated by CD68 staining. The accumulation of CD68-positive cells was severe in the myocardium of the EAM 3-week group. The median (interquartile range) SWDS of RVFW was significantly higher in the EAM 3-week group [9.9 (6.5-11.0) m/s/kHz] than in the control group [5.4 (4.5-6.8) m/s/kHz] (P = 0.034). The median SWDS of LVFW was also significantly higher in the EAM 3-week group [8.1 (6.4-11.0) m/s/kHz] than in the control group [4.4 (4.2-4.8) m/s/kHz] (P = 0.003). SWDS and the percentage of CD68-positive area showed a significant correlation in RVFW (R2 = 0.64, P < 0.001) and LVFW (R2 = 0.73, P < 0.001). This study showed that SWDS was elevated in ventricular walls with acute inflammation and also significantly correlated with the degree of myocardial inflammation. These results suggest the potential of SWDS in estimating the histological severity of acute myocarditis.

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  • Assessment of congestion and clinical outcomes in patients with chronic heart failure using shear wave elasticity. International journal

    Rie Nakayama, Yoichi Takaya, Kazufumi Nakamura, Rika Takemoto, Norihisa Toh, Hiroshi Ito

    ESC heart failure   9 ( 2 )   1279 - 1286   2022.4

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    AIMS: The relief of congestion is essential for the prevention of worsening heart failure (HF) resulting in hospitalizations. Assessment of the degree of organ congestion in the chronic phase of HF is important for determining therapeutic strategies. The aim of this study was to evaluate the efficacy of shear wave (SW) elasticity for assessing congestion and clinical outcomes in patients with chronic HF. METHODS AND RESULTS: We prospectively enrolled 345 consecutive patients with chronic HF who underwent SW elastography at outpatient clinic. Patients were divided into two groups according to the median value of SW elasticity: low group (SW elasticity <6.4 kPa, n = 176) and high group (SW elasticity ≥6.4 kPa, n = 169). The endpoint was cardiovascular death or hospitalization for HF. During the median follow-up period of 19 months (range: 7-36 months), cardiovascular death or hospitalization for HF occurred in 4 patients of low group and 27 patients of high group. In high group, 8 patients died, and 19 patients were hospitalized for HF. In low group, 3 patients died, and 1 patient was hospitalized. Kaplan-Meier analysis showed that the event-free survival rate was worse in high group than in low group (log-rank test, P = 0.004). After adjusting for variables, high SW elasticity was independently related to cardiac events. In multivariate regression analysis, SW elasticity was correlated with left atrial volume index, early diastolic mitral inflow velocity to mitral annular velocity ratio, and inferior vena cava diameter. CONCLUSIONS: The SW elasticity reflected haemodynamic congestion in patients with chronic HF, which was related to cardiac events.

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  • CTにおけるPericoronary Fat Attenuation Indexは虚血性心疾患の既往がない患者における心不全入院を予測する(Pericoronary Fat Attenuation Index on Computed Tomography Predicts Hospitalization for Heart Failure in Patients without History of Ischemic Heart Disease)

    中島 充貴, 三好 亨, 市川 啓之, 西原 大裕, 三木 崇史, 高谷 陽一, 横濱 ふみ, 中山 理絵, 杜 徳尚, 伊藤 浩

    日本循環器学会学術集会抄録集   86回   MPJ05 - 2   2022.3

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  • Left atrial appendage morphology with the progression of atrial fibrillation. International journal

    Yoichi Takaya, Rie Nakayama, Fumi Yokohama, Norihisa Toh, Koji Nakagawa, Masakazu Miyamoto, Hiroshi Ito

    PloS one   17 ( 11 )   e0278172   2022

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    Left atrial appendage (LAA) size is crucial for determining the indication of transcatheter LAA closure. The aim of this study was to evaluate the differences in LAA morphology according to the types of atrial fibrillation (AF). A total of 299 patients (mean age: 67 ± 13 years) who underwent transesophageal echocardiography (TEE) were included. Patients were classified into non-AF (n = 64), paroxysmal AF (n = 86), persistent AF (n = 87), or long-standing persistent AF (n = 62). LAA morphology, including LAA ostial diameter and depth, was assessed using TEE. Patients with long-standing persistent AF had larger LAA ostial diameter and depth and lower LAA flow velocity. The maximum LAA ostial diameter was 19 ± 4 mm in patients with non-AF, 21 ± 4 mm in patients with paroxysmal AF, 23 ± 5 mm in patients with persistent AF, and 26 ± 5 mm in patients with long-standing persistent AF. LAA ostial diameter was increased by 2 or 3 mm with the progression of AF. LAA ostial diameter was correlated with LA volume index (R = 0.37, P < 0.01) and the duration of continuous AF (R = 0.30, P < 0.01), but not with age or the period from the onset of AF. In conclusion, LAA size was increased with the progression of AF.

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  • Usefulness of cardiac fusion imaging with computed tomography and Doppler echocardiography in the assessment of conduit stenosis in complex adult congenital heart disease International journal

    Nobuhisa Watanabe, Norihisa Toh, Yoichi Takaya, Rie Nakayama, Fumi Yokohama, Kazuhiro Osawa, Toru Miyoshi, Teiji Akagi, Susumu Kanazawa, Hiroshi Ito

    Journal of Cardiology   78 ( 6 )   473 - 479   2021.12

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    Background: Noninvasive assessment of stenotic lesions in patients with complex adult congenital heart disease (ACHD) is challenging due to its complex morphology. The simultaneous two-screen display of multidetector-computed tomography (MDCT) and real-time echogram (STDME) technology can display a virtual multi-planar reconstruction from MDCT corresponding to the same cross-sectional image from transthoracic echocardiography (TTE). We investigated the usefulness of the STDME technology for stenosis severity assessment in complex ACHD patients. Methods: Twenty-four complex ACHD patients with stenotic lesions were enrolled in this study. All patients underwent TTE and the STDME technology within a week after MDCT. Peak velocity and pressure gradient (PG) across the stenotic site were measured using continuous wave Doppler. Cardiac catheterization was performed in 17 patients. Results: Nine out of the twenty-four patients had undergone repair with a conduit. Peak velocity and PG from the STDME technology were higher than those from TTE (peak velocity: 3.1 ± 1.1 vs. 2.8 ± 1.0 m/s
    peak PG: 43 ± 28 vs. 34 ± 21 mmHg
    both p &lt
    0.01). Peak PG from the STDME technology showed significant correlations with those from catheterization in patients with a conduit (n=7) and those without a conduit (n=10) (r = 0.795 and 0.880, respectively
    both p &lt
    0.05), while peak PG from TTE was correlated with catheterization measurements only in patients without a conduit (r = 0.850, p &lt
    0.05). Conclusions: The STDME technology enables more accurate assessment of conduit stenosis severity than does TTE in complex ACHD patients.

    DOI: 10.1016/j.jjcc.2021.06.008

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  • Efficacy of shear wave elasticity for evaluating myocardial hypertrophy in hypertensive rats. International journal

    Yoichi Takaya, Kazufumi Nakamura, Rie Nakayama, Hiroaki Ohtsuka, Naofumi Amioka, Megumi Kondo, Kaoru Akazawa, Yuko Ohno, Keishi Ichikawa, Yukihiro Saito, Satoshi Akagi, Masashi Yoshida, Toru Miyoshi, Hiroshi Ito

    Scientific reports   11 ( 1 )   22812 - 22812   2021.11

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    Shear wave (SW) imaging is a novel ultrasound-based technique for assessing tissue characteristics. SW elasticity may be useful to assess the severity of hypertensive left ventricular (LV) hypertrophy. This study aimed to evaluate the efficacy of SW elasticity for assessing the degree of myocardial hypertrophy using hypertensive rats. Rats were divided into hypertension group and control group. SW elasticity was measured on the excised heart. Myocardial hypertrophy was assessed histologically. LV weight was greater in hypertension group. An increase in interventricular septum and LV free wall thicknesses was observed in hypertension group. SW elasticity was significantly higher in hypertension group than in control group (14.6 ± 4.3 kPa vs. 6.5 ± 1.1 kPa, P < 0.01). The cross-sectional area of cardiomyocytes was larger in hypertension group than in control group (397 ± 50 μm2 vs. 243 ± 14 μm2, P < 0.01), and SW elasticity was positively correlated with the cross-sectional area of cardiomyocytes (R = 0.96, P < 0.01). This study showed that SW elasticity was higher in hypertensive rats and was closely correlated with the degree of myocardial hypertrophy, suggesting the efficacy of SW elasticity for estimating the severity of hypertensive LV hypertrophy.

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  • Importance of direct right-to-left shunt as high-risk patent foramen ovale associated with cryptogenic stroke

    Yoichi Takaya, Rie Nakayama, Teiji Akagi, Fumi Yokohama, Takashi Miki, Koji Nakagawa, Norihisa Toh, Hiroshi Ito

    Echocardiography   38 ( 11 )   1887 - 1892   2021.11

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    Background: Because transcatheter closure of patent foramen ovale (PFO) has become effective for preventing cryptogenic stroke (CS), it is necessary to determine high-risk PFO associated with CS. This study aimed to clarify the importance of direct right-to-left (RL) shunt through the PFO for identifying high-risk PFO. Methods: We analyzed 137 patients with and without CS who were confirmed to have PFO. The timing of RL shunt through the PFO was evaluated by cardiac cycles after right atrium (RA) opacification on saline contrast transesophageal echocardiography. Direct RL shunt was defined as microbubbles crossing the PFO before and at the same time of RA opacification. Results: Cardiac cycles of microbubbles crossing the PFO were shorter in patients with CS than in those without CS (2.0 ± 2.2 vs.5 ± 1.1, p &lt
     0.01). Direct RL shunt was more frequently observed in patients with CS than in those without CS (77% vs 29%, p &lt
     0.01), with a sensitivity of 79% and a specificity of 71% for the association with CS. Multivariate analysis revealed that direct RL shunt was related to atrial septal aneurysm and low-angle PFO. Regarding functional features of PFO, the detection rate of CS was 50% for large RL shunt alone, and was increased to 83% when direct RL shunt was added. Conclusion: Direct RL shunt was associated with CS and had the incremental value in detecting PFO associated with CS for large RL shunt. The timing of RL shunt can be valuable for identifying high-risk PFO.

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  • Efficacy of shear wave elastography for evaluating right ventricular myocardial fibrosis in monocrotaline-induced pulmonary hypertension rats. International journal

    Rie Nakayama, Yoichi Takaya, Kazufumi Nakamura, Megumi Kondo, Kaoru Kobayashi, Yuko Ohno, Naofumi Amioka, Satoshi Akagi, Masashi Yoshida, Toru Miyoshi, Hiroshi Ito

    Journal of cardiology   78 ( 1 )   17 - 23   2021.7

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    BACKGROUND: Right ventricular (RV) function is important for outcomes in pulmonary hypertension. Evaluation of RV myocardial characteristics is useful to assess the disease severity. Shear wave elastography (SWE) provides information of shear wave (SW) elasticity, which is related to tissue hardness, and SW dispersion slope, which reflects tissue viscosity. This study aimed to test the hypothesis that SW elasticity is increased and SW dispersion slope is decreased in the right ventricle of monocrotaline (MCT)-induced pulmonary hypertension rats. METHODS: Rats were divided into MCT-induced pulmonary hypertension group (n = 10) and control group (n = 10). SW elasticity and SW dispersion slope were measured on excised hearts. Myocardial fibrosis was evaluated histologically. RESULTS: RV hypertrophy was observed in the MCT group. SW elasticity of right ventricle was higher in the MCT group than in the control group (3.5 ± 0.9 kPa vs. 2.5 ± 0.4 kPa, p < 0.01). SW dispersion slope of right ventricle was lower in the MCT group than in the control group (5.3 ± 1.7 m/s/kHz vs. 7.7 ± 1.5 m/s/kHz, p < 0.01). The fibrosis area of right ventricle was increased in MCT group compared with control group (18 ± 5% vs. 8 ± 3%, p < 0.01), and was positively related to SW elasticity and negatively related to SW dispersion slope. CONCLUSIONS: Higher SW elasticity and lower SW dispersion slope were observed in the fibrotic myocardium of right ventricle in MCT-induced pulmonary hypertension rats. SWE may have the potential to evaluate RV function by assessing myocardial characteristics.

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  • Fusion imaging of three-dimensional echocardiographic speckle-tracking with cardiac computed tomography for identification of myocardial ischemia International journal

    Yoichi Takaya, Rie Nakayama, Nobuhisa Watanabe, Norihisa Toh, Toru Miyoshi, Hiroshi Ito

    Health Science Reports   4 ( 2 )   e285   2021.6

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    DOI: 10.1002/hsr2.285

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  • Low-Angle Patent Foramen Ovale (PFO): High-Risk PFO Morphology Associated with Paradoxical Embolism. International journal

    Rie Nakayama, Yoichi Takaya, Teiji Akagi, Takashi Miki, Koji Nakagawa, Norihisa Toh, Hiroshi Ito

    CASE (Philadelphia, Pa.)   5 ( 3 )   183 - 185   2021.6

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    • Identification of high-risk PFO associated with stroke is important. • Low-angle PFO is reported to be one of the high-risk PFO morphologies. • Low-angle PFO can allow venous blood to flow directly from the IVC to the LA. • The case showed direct blood flow from the IVC to LA through the low-angle PFO.

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  • Efficacy of shear wave elastography for assessment of liver function in patients with heart failure. International journal

    Rie Nakayama, Yoichi Takaya, Kazufumi Nakamura, Norihisa Toh, Hiroshi Ito

    ESC heart failure   8 ( 3 )   1751 - 1758   2021.6

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    AIMS: Liver dysfunction is important for prognosis in heart failure (HF). Shear wave elastography (SWE), which is a novel ultrasound technique for charactering tissues, has been used in liver diseases. However, clinical implication of SWE, including dispersion slope, remains unknown in heart diseases. This study aimed to evaluate the efficacy of SWE assessing liver function in the severity of HF. METHODS AND RESULTS: We enrolled 316 consecutive patients with or suspected heart diseases, who were classified according to the American College of Cardiology Foundation/American Heart Association stage of HF, including 37 with Stage A, 139 with Stage B, 114 with Stage C, and 26 with Stage D, and 45 normal subjects. Elasticity and dispersion slope of shear wave were assessed according to the HF stage. Elasticity and dispersion slope were not elevated in normal subjects and patients with Stage A. Elasticity was slightly increased from Stage A to Stage C and was remarkably elevated in Stage D (normal: 5.2 ± 1.1 kPa, Stage A: 5.4 ± 1.2 kPa, Stage B: 6.4 ± 1.8 kPa, Stage C: 7.8 ± 3.5 kPa, and Stage D: 17.7 ± 12.7 kPa), whereas dispersion slope was gradually increased from Stage A to Stage D (normal: 9.7 ± 1.7m/s/kHz, Stage A: 10.4 ± 1.6m/s/kHz, Stage B: 11.7 ± 2.4m/s/kHz, Stage C: 13.2 ± 3.4m/s/kHz, and Stage D: 17.6 ± 5.6 m/s/kHz). In the early HF stage, dispersion slope was elevated. In the advanced HF stage, both elasticity and dispersion slope were elevated. Liver function test abnormalities were observed only from Stage C or Stage D. CONCLUSIONS: Dispersion slope could detect early liver damage, and the combination of elasticity and dispersion slope could clarify the progression of liver dysfunction in HF. SWE may be valuable to manage therapeutic strategies in patients with HF.

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  • Efficacy and safety of atrial septal defect closure using Occlutech Figulla Flex II compared with Amplatzer Septal Occluder.

    Rie Nakayama, Yoichi Takaya, Teiji Akagi, Nobuhisa Watanabe, Takashi Miki, Koji Nakagawa, Norihisa Toh, Hiroshi Ito

    Heart and vessels   36 ( 5 )   704 - 709   2021.5

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    Few studies have reported the efficacy of Occlutech Figulla Flex II (FFII) device compared with Amplatzer Septal Occluder (ASO) device. The aim of this study was to examine the efficacy and safety of FFII compared with ASO for transcatheter atrial septal defect (ASD) closure. We retrospectively evaluated 190 patients using FFII and 190 patients using ASO who underwent transcatheter ASD closure. ASD characteristics were evaluated by transesophageal echocardiography. The prevalence of procedural complications, including erosion, device embolization, stroke, and new-onset atrial arrhythmia, and the presence of a residual shunt were evaluated between the two groups during 12-month follow-up. FFII was used more frequently than ASO in patients with a deficient aortic rim or septal malalignment (P = 0.02, P < 0.01, respectively). The procedural complications of erosion, device embolization, and stroke did not occur in any patients. New-onset atrial arrhythmia occurred in 3 patients of the FFII group and 4 patients of the ASO group, and the difference between the two groups was not significant (P = 0.70). A large residual shunt (≥ 3 mm) was observed in 6 patients of the FFII group and 5 patients of the ASO group, and the difference between the two groups was not significant (P = 0.76). FFII was used frequently in patients with high-risk ASD morphology; however, there was no difference in the prevalence of procedural complications or efficacy between patients using FFII and those using ASO.

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  • Feasibility of transcatheter closure for absent aortic rim in patients with atrial septal defect International journal

    Yoichi Takaya, Teiji Akagi, Koji Nakagawa, Rie Nakayama, Takashi Miki, Norihisa Toh, Hiroshi Ito

    Catheterization and Cardiovascular Interventions   97 ( 5 )   859 - 864   2021.4

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    Objectives: This study aimed to assess the feasibility of transcatheter atrial septal defect (ASD) closure in patients with absent aortic rim. Background: The indication of transcatheter closure for ASD with absent aortic rim is controversial. Methods: We enrolled 547 patients with ASD who were scheduled for transcatheter closure. Morphologies of aortic rim were evaluated using transesophageal echocardiography (TEE). Results: Aortic rim of &lt
    5 mm was observed in 396 (72%) patients
    128 (23%) had absent aortic rim of 0 mm, and 268 (49%) had deficient aortic rim of &gt
    0 to &lt
    5 mm. Patients with absent aortic rim frequently had aortic rim absence at an angle of 0° on TEE and septal malalignment. Of the 128 patients with absent aortic rim, 126 (98%) successfully underwent transcatheter closure, while 2 (2%) failed transcatheter closure due to a large defect with severe septal malalignment. The success rate of transcatheter closure was similar between patients with absent aortic rim and those with deficient aortic rim (98% vs. 99%, p =.45). After the procedure, no patients had erosion or device embolization during a median follow-up of 24 months. Conclusions: Transcatheter closure was successfully performed without adverse events in patients with absent aortic rim, as well as in those with deficient aortic rim. Our findings can be valuable to determine the indication of transcatheter closure in patients with ASD.

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  • 腎ドプラ法による二心室修復術後の成人先天性心疾患での腎うっ血評価の試み

    杜 徳尚, 武本 梨佳, 渡辺 修久, 横濱 ふみ, 中山 理絵, 高谷 陽一, 赤木 禎治, 伊藤 浩

    超音波医学   48 ( Suppl. )   S683 - S683   2021.4

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  • 拡張機能学再考:beyond E/E' Shear wave imagingを用いた心筋性状評価

    高谷 陽一, 中山 理絵, 網岡 尚史, 杜 徳尚, 中村 一文, 伊藤 浩

    超音波医学   48 ( Suppl. )   S205 - S205   2021.4

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  • 下縁完全欠損症例に対する経皮的心房中隔欠損閉鎖術

    駿河 宗城, 赤木 禎治, 三木 崇史, 中山 理絵, 高谷 陽一, 杜 徳尚, 中川 晃志, 中村 一文, 伊藤 浩

    日本心血管インターベンション治療学会抄録集   29回   618 - 618   2021.2

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  • 卵円孔開存症に対する経皮的デバイス閉鎖術の成績と合併症 単一施設での経験から(Outcomes and complications after transcatheter device closure for patent foramen ovale: a single-center experience)

    三木 崇史, 赤木 禎治, 中山 理絵, 高谷 陽一, 中川 晃志, 伊藤 浩

    日本心血管インターベンション治療学会抄録集   29回   1383 - 1383   2021.2

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  • Morphological assessments of deficient posterior-inferior rim for transcatheter closure of atrial septal defect International journal

    Yoichi Takaya, Teiji Akagi, Koji Nakagawa, Rie Nakayama, Takashi Miki, Norihisa Toh, Hiroshi Ito

    Catheterization and Cardiovascular Interventions   97 ( 1 )   135 - 141   2021.1

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    Objectives: This study aimed to determine morphological characteristics of deficient posterior-inferior rim for transcatheter atrial septal defect (ASD) closure success. Background: The feasibility of transcatheter closure of ASD with deficient posterior-inferior rim remains unclear. Methods: Of 869 patients with ASD who were scheduled transcatheter closure, 121 with posterior-inferior rim of &lt
    5 mm were included. Posterior-inferior rim morphologies were evaluated by transesophageal echocardiography. Results: One hundred six patients successfully underwent transcatheter closure, while 15 patients failed. These 15 patients had complete deficient posterior-inferior rim of 0 mm and/or a large defect of ≥38 mm. Multivariate logistic regression analysis showed that transcatheter closure failure was independently related to complete deficient posterior-inferior rim and a large defect of ≥38 mm. Incomplete deficient posterior-inferior rim of &gt
    0 to &lt
    5 mm was observed in 84 patients. All these patients successfully underwent transcatheter closure, except two patients with a large defect of ≥38 mm. Complete deficient posterior-inferior rim was observed in 37 patients. The frequency of complete deficient posterior-inferior rim was higher in patients who failed transcatheter closure (87% vs. 23%, p &lt
    .01), but transcatheter closure was performed successfully if the range of complete deficient rim was ≤30°. After the procedure, no adverse events occurred during a median follow-up of 24 months. Conclusions: Most patients with deficient posterior-inferior rim successfully underwent transcatheter closure. Transcatheter closure could be performed even in patients with complete deficient posterior-inferior rim if the range was partial. Our findings can help to identify candidates for transcatheter closure.

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  • Efficacy of Saline Contrast Transthoracic Echocardiography for Identifying High-Risk Patent Foramen Ovale International journal

    Kazuki Suruga, Yoichi Takaya, Rie Nakayama, Teiji Akagi, Koji Nakagawa, Nobuhisa Watanabe, Madoka Haruna, Norihisa Toh, Hiroshi Ito

    Journal of the American Society of Echocardiography   34 ( 1 )   97 - 98   2021.1

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  • Importance of saline contrast transthoracic echocardiography for evaluating large right-to-left shunt in patent foramen ovale associated with cryptogenic stroke International journal

    Yoichi Takaya, Rie Nakayama, Teiji Akagi, Fumi Yokohama, Takashi Miki, Koji Nakagawa, Norihisa Toh, Hiroshi Ito

    International Journal of Cardiovascular Imaging   38 ( 3 )   515 - 520   2021

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    Transcatheter closure of patent foramen ovale (PFO) is an effective therapy for preventing recurrent stroke in very specific patient cohorts, such as cryptogenic stroke (CS). The identification of high-risk PFO, which is more likely to be linked to CS, is essential. This study aimed to assess the accuracy of saline contrast transthoracic echocardiography (TTE) for evaluating large right-to-left (RL) shunt. We enrolled 119 patients with or without CS who were confirmed to have PFO by transesophageal echocardiography (TEE) or catheterization. The severity of RL shunt evaluated by TTE and TEE was classified as follows: small (&lt
    10 microbubbles), moderate (10–20 microbubbles), and large (&gt
    20 microbubbles). With TTE, large RL shunt was observed in 94 (79%) of 119 patients, including 66 of 74 with CS and 28 of 45 without CS. With TEE, large RL shunt was observed in 33 (28 %) patients, including 26 with CS and 7 without CS. TTE showed large RL shunt more frequently than TEE (p &lt
    0.01). Large RL shunt evaluated by TTE had a sensitivity of 89 % and an accuracy of 70 % for the association with CS, whereas large RL shunt evaluated by TEE had a sensitivity of 35% and an accuracy of 56 %. Accuracy was significantly greater in TTE than in TEE (p = 0.02). In conclusion, TTE identified large RL shunt associated with CS with higher sensitivity and accuracy compared to TEE. Our findings suggest that the decision for device closure should be made based on the severity of RL shunt by TTE.

    DOI: 10.1007/s10554-021-02418-6

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  • 二心室修復術後とFontan術後の成人先天性心疾患での腎ドプラ法を用いた体うっ血の評価

    杜 徳尚, 武本 梨佳, 渡辺 修久, 横濱 ふみ, 中山 理絵, 高谷 陽一, 赤木 禎治, 伊藤 浩

    超音波医学   47 ( Suppl. )   S512 - S512   2020.11

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  • ハイリスク卵円孔開存の同定における造影経胸壁心エコー検査の有効性(Efficacy of Contrast Transthoracic Echocardiography on Identification of High-Risk Patent Foramen Ovale)

    駿河 宗城, 高谷 陽一, 中山 理絵, 赤木 禎治, 三木 崇史, 中川 晃志, 杜 徳尚, 伊藤 浩

    日本循環器学会学術集会抄録集   84回   OJ32 - 1   2020.7

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  • Importance of Abdominal Compression Valsalva Maneuver and Microbubble Grading in Contrast Transthoracic Echocardiography for Detecting Patent Foramen Ovale International journal

    Yoichi Takaya, Nobuhisa Watanabe, Madoka Ikeda, Teiji Akagi, Rie Nakayama, Koji Nakagawa, Norihisa Toh, Hiroshi Ito

    Journal of the American Society of Echocardiography   33 ( 2 )   201 - 206   2020.2

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    Background: Although transthoracic echocardiography (TTE) may be useful for patent foramen ovale (PFO) screening, the optimal methodologies remain unclear. The aims of this study were to evaluate the efficacy of the abdominal compression Valsalva maneuver and identify the optimal cutoff value of microbubbles in contrast TTE for detecting PFO, compared with transesophageal echocardiography and catheterization as the reference. Methods: One hundred thirty-four patients with cryptogenic stroke or migraine who had suspected PFO and underwent TTE and transesophageal echocardiography plus catheterization were enrolled. The sensitivity, specificity, and accuracy of TTE for PFO detection were analyzed according to different provocations (spontaneous Valsalva maneuver, abdominal compression Valsalva maneuver) and different cutoff values of microbubbles for a positive result (at least one microbubble, at least five microbubbles). Results: Eighty patients had PFO confirmed by transesophageal echocardiography and catheterization. When the cutoff was at least one microbubble, the sensitivity of TTE in detecting PFO was 93% with the spontaneous Valsalva maneuver and 99% with the abdominal compression Valsalva maneuver. When the cutoff was at least five microbubbles, sensitivity was 85% with the spontaneous Valsalva maneuver and 99% with the abdominal compression Valsalva maneuver. With the abdominal compression Valsalva maneuver, specificity was increased using the cutoff of at least five microbubbles compared with at least one microbubble (89% vs 57%). The abdominal compression Valsalva maneuver with the cutoff of at least 5 microbubbles provided the greatest accuracy of 95%. Conclusions: TTE with the abdominal compression Valsalva maneuver had excellent sensitivity. The cutoff of at least five microbubbles increased specificity. Our findings suggest that TTE with these criteria is valuable for PFO diagnosis.

    DOI: 10.1016/j.echo.2019.09.018

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  • ACHDに対するInterventional Cardiologyの最新知見と将来展望 卵円孔開存(Update and Prospect on Interventional Cardiology for ACHD Transcatheter Closure of Patent Foramen Ovale)

    高谷 陽一, 赤木 禎治, 中川 晃志, 中山 理絵, 三木 崇史, 伊藤 浩

    日本成人先天性心疾患学会雑誌   9 ( 1 )   177 - 177   2020.1

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  • 成人先天性心疾患における肺高血圧症の病態と治療 最新知見とガイドラインからみた肺血管拡張療法 高度肺高血圧症を伴う成人先天性心疾患に対するTreat & Repair pre-tricuspid shunt

    高谷 陽一, 赤木 禎治, 中川 晃志, 中山 理絵, 三木 崇史, 伊藤 浩

    日本成人先天性心疾患学会雑誌   9 ( 1 )   181 - 181   2020.1

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  • Impact of Right Ventricular Dilatation in Patients with Atrial Septal Defect. International journal

    Rie Nakayama, Yoichi Takaya, Teiji Akagi, Koji Nakagawa, Nobuhisa Watanabe, Saori Nobusada, Toshi Matsushita, Norihisa Toh, Susumu Kanazawa, Hiroshi Ito

    Journal of interventional cardiology   2020   9509105 - 9509105   2020

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    OBJECTIVE: The aim of this study was to examine the relationship between right ventricular (RV) volume and exercise capacity in adult patients with atrial septal defect (ASD) and to determine the degree of RV dilatation for transcatheter ASD closure. BACKGROUND: RV dilatation is an indication of transcatheter ASD closure; however, few studies have reported the clinical significance of RV dilatation. METHODS: We enrolled 82 consecutive patients (mean age, 49 ± 18 years; female, 68%) who underwent cardiac magnetic resonance imaging and symptom-limited cardiopulmonary exercise test before ASD closure. The relationship between RV volume and peak oxygen uptake (VO2) was evaluated. RESULTS: The mean RV end-diastolic volume index was 108 ± 27 ml/m2 (range, 46 to 180 ml/m2). The mean peak VO2 was 24 ± 7 ml/min/kg (range, 14 to 48 ml/min/kg), and the mean predicted peak VO2 was 90 ± 23%. There were significant negative relationships of RV end-diastolic volume index with peak VO2 (r = -0.28, p < 0.01) and predicted peak VO2 (r = -0.29, p < 0.01). The cutoff value of RV end-diastolic volume index <80% of predicted peak VO2 was 120 ml/m2, with the sensitivity of 49% and the specificity of 89%. CONCLUSIONS: There was a relationship between RV dilatation and exercise capacity in adult patients with ASD. RV end-diastolic volume index ≥120 ml/m2 was related to the reduction in peak VO2. This criterion of RV dilatation may be valuable for the indication of transcatheter ASD closure.

    DOI: 10.1155/2020/9509105

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  • Clinical Significance of Septal Malalignment for Transcatheter Closure of Atrial Septal Defect International journal

    Yoichi Takaya, Teiji Akagi, Koji Nakagawa, Rie Nakayama, Takashi Miki, Nobuhisa Watanabe, Norihisa Toh, Hiroshi Ito

    Journal of Interventional Cardiology   2020   6090612 - 6090612   2020

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    Background. Septal malalignment is related to erosion and device embolization in transcatheter closure of atrial septal defect (ASD), but limited information is available. Objectives. This study aimed to assess clinical significance of septal malalignment and to determine appropriate evaluation of ASD diameter, including the selection of device size. Methods. Four hundred and seventeen patients with ASD who underwent transcatheter closure were enrolled. Septal malalignment was defined as separation between the septum primum and the septum secundum on transesophageal echocardiography. Results. One hundred and eighty-four patients had septal malalignment. The frequency of septal malalignment increased with age reaching around 50% in adult patients. Septal malalignment was related to aortic rim deficiency. The distance of separation between the septum primum and the septum secundum was 5 ± 2 mm (range, 1-11 mm). In patients with septal malalignment, the ASD diameter measured at the septum primum was 19 ± 6 mm, while the ASD diameter measured at the septum secundum was 16 ± 6 mm. There was a difference of 4 ± 2 mm (range, 0-8 mm) between the ASD diameter measured at the septum primum and that measured at the septum secundum. For transcatheter closure, the Amplatzer Septal Occluder device size 2-3 mm larger and the Occlutech Figulla Flex II device size 4-7 mm larger than the ASD diameter measured at the septum primum were frequently used. During the study period, erosion or device embolization did not occur in all of the patients. Conclusions. Septal malalignment is highly prevalent in adult patients with aortic rim deficiency. The measurement of ASD diameter at the septum primum can be valuable for the selection of device size in patients with septal malalignment.

    DOI: 10.1155/2020/6090612

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  • 薬物抵抗性片頭痛に対する卵円孔閉鎖デバイスの有効性と安全性を検証する医師主導治験

    赤木 禎治, 高谷 陽一, 中山 理絵, 三木 崇史, 小坂田 陽介, 菱川 望, 阿部 康二, 伊藤 浩

    日本頭痛学会誌   46 ( 2 )   419 - 419   2019.11

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  • 薬物治療抵抗性の片頭痛患者に対する経皮的卵円孔閉鎖術の有効性

    赤木 禎治, 高谷 陽一, 中山 理絵, 三木 崇史, 高橋 義秋, 阿部 康二, 伊藤 浩

    日本頭痛学会誌   46 ( 2 )   420 - 420   2019.11

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  • 脳卒中予防の新規治療 経皮的卵円孔開存閉鎖術の役割

    赤木 禎治, 高谷 陽一, 三木 崇史, 中山 理絵, 中川 晃志, 伊藤 浩

    日本心血管インターベンション治療学会抄録集   28回   [MO18 - 001]   2019.9

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  • 可動性の大きい心房中隔を有する卵円孔開存に対する至適デバイス選択 どのような時に大きな閉鎖栓を選択するのか?

    三木 崇史, 赤木 禎治, 中山 理絵, 高谷 陽一, 中川 晃志, 伊藤 浩

    日本心血管インターベンション治療学会抄録集   28回   [BP2 - 007]   2019.9

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  • Identification of High-Risk Patent Foramen Ovale Associated With Cryptogenic Stroke: Development of a Scoring System. International journal

    Rie Nakayama, Yoichi Takaya, Teiji Akagi, Nobuhisa Watanabe, Madoka Ikeda, Koji Nakagawa, Norihisa Toh, Hiroshi Ito

    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography   32 ( 7 )   811 - 816   2019.7

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    BACKGROUND: Transcatheter closure of patent foramen ovale (PFO) has become an effective therapeutic strategy for cryptogenic stroke (CS). The identification of high-risk PFO is essential, but the data are limited. This study aimed to clarify the factors related to CS and to develop a score for high-risk PFO. METHODS: We retrospectively analyzed 57 patients with prior CS and 50 without CS who were scheduled for transcatheter closure. PFO characteristics were evaluated by transesophageal echocardiography. Based on factors related to CS, we estimated the risk score. RESULTS: Patients with CS had a greater frequency of large-size PFO (≥2 mm in height), long-tunnel PFO (≥10 mm in length), atrial septal aneurysm, hypermobile interatrial septum, prominent Eustachian valve or Chiari's network, the large right-to-left shunt at rest and during Valsalva maneuver, and low-angle PFO (≤10° of PFO angle from inferior vena cava), compared with patients without CS. Multivariate analysis showed that long-tunnel PFO, the presence of hypermobile interatrial septum, the presence of prominent Eustachian valve or Chiari's network, the large right-to-left shunt during Valsalva maneuver, and low-angle PFO were independently related to CS. When the score was estimated based on 1 point for each factor, the proportion of CS was markedly elevated with a score of ≥2 points. The probability of CS was markedly different between scores of ≤1 or ≥2 points. CONCLUSIONS: PFO risk can be assessed with a score based on high-risk features. The presence of two or more high-risk PFO features is associated with CS.

    DOI: 10.1016/j.echo.2019.03.021

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  • 片頭痛患者における卵円孔開存合併頻度と短絡量の検討

    赤木 禎治, 高谷 陽一, 中山 理絵, 中川 晃志, 三木 崇史, 伊藤 浩

    日本頭痛学会誌   45 ( 2 )   416 - 416   2018.11

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  • Early eicosapentaenoic acid treatment after percutaneous coronary intervention reduces acute inflammatory responses and ventricular arrhythmias in patients with acute myocardial infarction: a randomized, controlled study. International journal

    Masayuki Doi, Kazumasa Nosaka, Toru Miyoshi, Mutsumi Iwamoto, Masahito Kajiya, Keisuke Okawa, Rie Nakayama, Wataru Takagi, Ko Takeda, Satoshi Hirohata, Hiroshi Ito

    International journal of cardiology   176 ( 3 )   577 - 82   2014.10

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    OBJECTIVE: We examined whether early loading of eicosapentaenoic acid (EPA) reduces clinical adverse events by 1 month, accompanied by a decrease in C-reactive protein (CRP) values in patients with acute myocardial infarction (MI). BACKGROUND: Acute MI triggers an inflammatory reaction, which plays an important role in myocardial injury. EPA could attenuate the inflammatory response. METHODS: This prospective, open-label, blinded endpoint, randomized trial consisted of 115 patients with acute MI. They were randomly assigned to the EPA group (57 patients) and the control group (58 patients). After percutaneous coronary intervention (PCI), 1800 mg/day of EPA was initiated within 24h. The primary endpoint was composite events, including cardiac death, stroke, re-infarction, ventricular arrhythmias, and paroxysmal atrial fibrillation within 1 month. RESULTS: Administration of EPA significantly reduced the primary endpoint within 1 month (10.5 vs 29.3%, p=0.01), especially the incidence of ventricular arrhythmias (7.0 vs 20.6%, p=0.03). Peak CRP values after PCI in the EPA group were significantly lower than those in the control group (median [interquartile range], 8.2 [5.6-10.2] mg/dl vs 9.7 [7.6-13.9] mg/dl, p<0.01). Logistic regression analysis showed that EPA use was an independent factor related to ventricular arrhythmia until 1 month, with an odds ratio of 0.29 (95% confidence interval, 0.09 to 0.96, p=0.04). CONCLUSIONS: Early EPA treatment after PCI in the acute stage of MI reduces the incidence of ventricular arrhythmias, and lowers CRP values.

    DOI: 10.1016/j.ijcard.2014.08.055

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  • Low serum level of secreted frizzled-related protein 5, an anti-inflammatory adipokine, is associated with coronary artery disease. International journal

    Toru Miyoshi, Masayuki Doi, Shinichi Usui, Mutsumi Iwamoto, Masahito Kajiya, Ko Takeda, Kazumasa Nosaka, Rie Nakayama, Keisuke Okawa, Wataru Takagi, Kazufumi Nakamura, Satoshi Hirohata, Hiroshi Ito

    Atherosclerosis   233 ( 2 )   454 - 459   2014.4

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    OBJECTIVE: Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipokine that is associated with insulin resistance in animals. To extend these observations to humans, we investigated the association of serum SFRP5 levels in subjects with and without coronary artery disease (CAD). METHODS: Subjects (n=185, 68±11 years, 79% male) suspected of having CAD were enrolled in the study and were divided into two groups, CAD and non-CAD subjects, according to the results of their coronary angiographies. Serum SFRP5 levels of the subjects were measured by an enzyme-linked immunosorbent assay. RESULTS: The serum SFRP5 levels in the subjects with CAD were significantly lower than those in the non-CAD subjects (median [interquartile range]: 47.7 [26.6] vs. 52.4 [29.6] ng/mL, respectively; p=0.02). The serum SFRP5 levels significantly correlated with body mass index, the homeostasis model of assessment of insulin resistance, adiponectin levels, and CAD severity. Multivariate logistic regression analysis revealed that a decreased serum SFRP5 level (log transformed) was independently associated with CAD for all subjects (adjusted odds ratio, 0.36; 95% confidence interval, 0.14-0.94; p=0.03). CONCLUSION: Serum SFRP5 levels are significantly associated with CAD in humans, suggesting that low SFRP5 levels may contribute to CAD.

    DOI: 10.1016/j.atherosclerosis.2014.01.019

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  • Serum adipocyte fatty acid-binding protein is independently associated with complex coronary lesions in patients with stable coronary artery disease.

    Masahito Kajiya, Toru Miyoshi, Masayuki Doi, Shinichi Usui, Mutsumi Iwamoto, Ko Takeda, Kazumasa Nosaka, Rie Nakayama, Satoshi Hirohata, Shozo Kusachi, Kazufumi Nakamura, Hiroshi Ito

    Heart and vessels   28 ( 6 )   696 - 703   2013.11

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    The association between circulating adipocyte fatty acid-binding protein (A-FABP) levels and coronary artery disease (CAD) is reported. We assessed whether plasma A-FABP levels are associated with angiographic coronary lesion morphology in patients with stable CAD. Serum A-FABP levels were analyzed in 115 patients with stable CAD (mean age 69 ± 10 years; 80 % men). These patients were angiographically studied and divided into two groups: simple lesions (n = 34) and complex lesions (n = 81). We also compared 50 age- and gender-matched controls with no evidence of CAD. Serum A-FABP levels in patients with stable CAD were significantly higher than those in controls. In patients with stable CAD, serum A-FABP levels were significantly higher in patients with complex lesions than in those with simple lesions: median (25th-75th percentile), 23.4 (17.7-30.8) vs 18.2 (12.2-24.7) ng/ml, P < 0.01. Serum A-FABP levels were also significantly associated with angiographic scores of extent of coronary lesion (r = 0.21, P = 0.02). Multiple logistic analysis that included dyslipidemia, statin therapy, and extent score demonstrated that serum A-FABP was independently associated with complex lesions. The multiple adjusted odds ratio for a complex lesion with a serum A-FABP level (per doubling) was 2.38 (95 % confidence interval, 1.03-6.41; P = 0.03). High serum A-FABP levels were significantly associated with complex coronary lesions in patients with stable CAD, suggesting that high A-FABP levels may be involved in coronary plaque vulnerability.

    DOI: 10.1007/s00380-012-0310-1

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  • Elevated serum adipocyte fatty acid-binding protein concentrations are independently associated with renal dysfunction in patients with stable angina pectoris. International journal

    Mutsumi Iwamoto, Toru Miyoshi, Masayuki Doi, Ko Takeda, Masahito Kajiya, Kazumasa Nosaka, Rie Nakayama, Satoshi Hirohata, Shinichi Usui, Shozo Kusachi, Kosuke Sakane, Kazuhfumi Nakamura, Hiroshi Ito

    Cardiovascular diabetology   11   26 - 26   2012.3

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    BACKGROUND: Chronic kidney disease (CKD) is associated with cardiovascular events. Adipocyte fatty acid-binding protein (A-FABP) plays an important role in atherosclerosis. We investigated whether plasma A-FABP is involved in renal function in patients with stable angina pectoris. METHODS: A total of 221 patients with significant coronary artery stenosis were enrolled after coronary angiography. CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2. The severity of coronary stenosis was assessed using a modified Gensini score and coronary angiography. Serum A-FABP levels were determined by enzyme-linked immunosorbent assay. RESULTS: Serum A-FABP levels were significantly correlated with both eGFR (r = -0.41, p < 0.01) and the severity of coronary artery stenosis (r = 0.16, p = 0.02), and these relationships remained significant after adjusting for confounding factors. The prevalence of CKD and multi-vessel disease was significantly higher among patients with serum A-FABP levels above the median value of 20.3 ng/ml than among patients with serum A-FABP levels below the median value (57% vs. 27%, p < 0.01 and 64% vs. 48%, p = 0.02, respectively). Multivariate analysis revealed that the presence of three-vessel disease in comparison with single-vessel disease was independently associated with the higher A-FABP (per doubling) (odds ratio; 2.26, 95% confidential interval; 1.28-3.98, p < 0.01) and tended to be associated with the lower eGFR (p = 0.06). CONCLUSION: Serum A-FABP may have a significant role in the interplay between renal dysfunction and coronary atherosclerosis.

    DOI: 10.1186/1475-2840-11-26

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  • Clinical Significance of Right Atrial Function in Patients with Heart Failure(タイトル和訳中)

    中山 理絵, 高谷 陽一, 西原 大裕, 吉田 優, 角南 春樹, 武本 梨佳, 杜 徳尚, 中村 一文

    日本循環器学会学術集会抄録集   88回   PJ050 - 3   2024.3

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  • 先天性心疾患患者の移行期医療:成人循環器医の協力を得る方策 成人先天性心疾患の診療の手助けとなる心エコー図検査

    武本 梨佳, 杜 徳尚, 高谷 陽一, 中山 理絵, 赤木 禎治, 中村 一文, 笠原 真悟, 大塚 文男

    日本循環器学会学術集会抄録集   88回   CS3 - 4   2024.3

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  • 【シン・エコーで冠動脈疾患に迫る】診断に負荷心エコーを活用する

    中山 理絵

    心エコー   25 ( 3 )   236 - 242   2024.3

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  • 成人期PDA閉鎖術の至適デバイス選択に対する心臓CTの有用性

    三木 崇史, 赤木 禎治, 中島 充貴, 中山 理絵, 高谷 陽一, 中川 晃志, 杜 徳尚, 中村 一文

    日本成人先天性心疾患学会雑誌   13 ( 1 )   124 - 124   2024.1

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  • 【心筋炎・心膜炎,感染性心内膜炎を診る,治す】心膜疾患を診る,治す 急性心(外)膜炎,慢性心膜液貯留の診断と治療

    中山 理絵, 伊藤 浩

    診断と治療   111 ( 10 )   1353 - 1357   2023.10

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    <文献概要>Headline 1 急性心膜炎は胸痛患者の約5%に認めるとされる.ただし,心膜炎に典型的な胸痛症状や心電図異常,心膜液貯留のすべてを認める症例は多くはない.2 心膜炎では,心タンポナーデと心筋炎の合併に注意する.3 急性期治療が不十分であると再発しやすい.したがって,確実な診断と原因究明,適切な治療が求められる.

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    Other Link: https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J00697&link_issn=&doc_id=20231013060018&doc_link_id=10.34433%2Fdt.0000000438&url=https%3A%2F%2Fdoi.org%2F10.34433%2Fdt.0000000438&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

  • 【心筋炎・心膜炎,感染性心内膜炎を診る,治す】心膜疾患を診る,治す 急性心(外)膜炎,慢性心膜液貯留の診断と治療

    中山 理絵, 伊藤 浩

    診断と治療   111 ( 10 )   1353 - 1357   2023.10

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    <文献概要>Headline 1 急性心膜炎は胸痛患者の約5%に認めるとされる.ただし,心膜炎に典型的な胸痛症状や心電図異常,心膜液貯留のすべてを認める症例は多くはない.2 心膜炎では,心タンポナーデと心筋炎の合併に注意する.3 急性期治療が不十分であると再発しやすい.したがって,確実な診断と原因究明,適切な治療が求められる.

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  • Efficacy of Shear Wave Elastography on Management of Heart Failure with Preserved Ejection Fraction(タイトル和訳中)

    中山 理絵, 高谷 陽一, 武本 梨佳, 杜 徳尚, 中村 一文, 伊藤 浩

    日本循環器学会学術集会抄録集   87回   OJ43 - 1   2023.3

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  • 急性心不全の1例

    細川 智巳, 中山 理絵

    心エコー   24 ( 3 )   318 - 322   2023.3

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  • 【心房細動・心室頻拍-そのリスクに迫る心エコー】心房細動のリスクに迫る 左心耳閉鎖の適応判定に必要な心エコー図検査

    中山 理絵

    心エコー   24 ( 3 )   267 - 273   2023.3

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  • 潜因性脳卒中を引き起こす卵円孔開存の心臓CTにおける形態学的特徴(Morphological Features on Cardiac CT of Patent Foramen Ovale Causing Cryptogenic Stroke)

    三木 崇史, 中川 晃志, 辻 真弘, 中島 充貴, 西原 大裕, 中山 理絵, 高谷 陽一, 三好 亨, 赤木 禎治, 伊藤 浩

    日本循環器学会学術集会抄録集   87回   PJ004 - 6   2023.3

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  • 左室駆出率が保たれた心不全の管理におけるShear Wave Elastographyの有効性(Efficacy of Shear Wave Elastography on Management of Heart Failure with Preserved Ejection Fraction)

    中山 理絵, 高谷 陽一, 武本 梨佳, 杜 徳尚, 中村 一文, 伊藤 浩

    日本循環器学会学術集会抄録集   87回   OJ43 - 1   2023.3

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  • Gore Cardioform ASD Occluderを用いた経皮的心房中隔欠損閉鎖術の初期成績

    古田 めぐみ, 赤木 禎治, 三木 崇史, 西原 大裕, 中山 理絵, 高谷 陽一, 中川 晃志, 伊藤 浩

    日本成人先天性心疾患学会雑誌   12 ( 1 )   154 - 154   2023.1

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  • Gore Cardioform ASD Occluderを用いた経皮的心房中隔欠損閉鎖術の初期成績

    古田 めぐみ, 赤木 禎治, 三木 崇史, 西原 大裕, 中山 理絵, 高谷 陽一, 中川 晃志, 伊藤 浩

    日本心臓病学会学術集会抄録   70回   O - 3   2022.9

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  • CTで評価された冠動脈周囲脂肪炎症と心不全発症との関係 単施設後ろ向き研究

    中島 充貴, 三好 亨, 市川 啓之, 西原 大裕, 三木 崇史, 高谷 陽一, 中山 理絵, 杜 徳尚, 伊藤 浩

    日本心臓病学会学術集会抄録   70回   O - 3   2022.9

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  • ブレイン・ハートチームで挑む脳卒中予防・治療戦略 地域で築くブレイン・ハートネットワーク PFOに起因する奇異性脳塞栓患者を的確に診断し治療に導く方策は?

    三木 崇史, 赤木 禎治, 西原 大裕, 中山 理絵, 高谷 陽一, 中川 晃志, 伊藤 浩, 木村 舞

    日本心臓病学会学術集会抄録   70回   S13 - 2   2022.9

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  • 【歯科衛生士のための心疾患患者さんへの対応ガイド】(Part 1)心疾患ってどんな病気?

    中山 理絵

    デンタルハイジーン   42 ( 8 )   840 - 845   2022.8

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  • 心臓CTによる卵円孔開存の診断能についての検討

    三木 崇史, 中川 晃志, 市川 啓之, 水野 智文, 中山 理絵, 川田 哲史, 高谷 陽一, 宮本 真和, 三好 亨, 赤木 禎治, 伊藤 浩

    日本心血管インターベンション治療学会抄録集   30回   [MO267] - [MO267]   2022.7

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  • Gore Cardioform ASD Occluderを用いた心房中隔欠損症のカテーテル閉鎖術 経食道エコーによるダブル4ポイント評価法

    赤木 禎治, 三木 崇史, 高谷 陽一, 中山 理絵, 中川 晃志, 伊藤 浩

    日本心血管インターベンション治療学会抄録集   30回   [MO398] - [MO398]   2022.7

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  • Amplatzer PFO Occluderを使用した経カテーテル卵円孔開存閉鎖術の初期成績

    三木 崇史, 赤木 禎治, 中山 理絵, 高谷 陽一, 中川 晃志, 伊藤 浩

    日本心血管インターベンション治療学会抄録集   30回   [MO397] - [MO397]   2022.7

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  • 奇異性脳塞栓症患者における卵円孔開存(PFO)形態について 年齢や心形態による検討

    中山 理絵, 高谷 陽一, 赤木 禎治, 三木 崇史, 横濱 ふみ, 中川 晃志, 杜 徳尚, 伊藤 浩

    超音波医学   49 ( Suppl. )   S700 - S700   2022.4

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  • 【ワンランク上の心エコー図検査-定量的評価していますか?】うっ血の定量的評価

    中山 理絵

    心エコー   23 ( 4 )   390 - 397   2022.4

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  • 重症大動脈弁狭窄症に合併する大動脈弁閉鎖不全症の臨床的意義

    横濱 ふみ, 高谷 陽一, 市川 啓之, 中山 理絵, 三木 崇史, 戸田 洋信, 杜 徳尚, 三好 亨, 伊藤 浩

    超音波医学   49 ( Suppl. )   S664 - S664   2022.4

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  • 心不全の重症度評価におけるShear Wave Elastographyの重要性(Importance of Shear Wave Elastography for Assessing Heart Failure Severity)

    中山 理絵, 高谷 陽一, 中村 一文, 武本 梨佳, 杜 徳尚, 伊藤 浩

    日本循環器学会学術集会抄録集   86回   MPJ12 - 2   2022.3

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  • 潜因性脳梗塞の再発予防を目指した経皮的卵円孔開存閉鎖術の初期経験 患者プロファイルと手術成績(Initial Experiences of Transcatheter Patent Foramen Ovale Closure for Prevention of Recurrent Cryptogenic Stroke: Patient's Profile and Procedure Outcome)

    三木 崇史, 赤木 禎治, 中山 理絵, 高谷 陽一, 中川 晃志, 伊藤 浩

    日本循環器学会学術集会抄録集   86回   PJ23 - 4   2022.3

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  • 成人複雑先天性心疾患患者における両心室修復術後の腎内血行動態が臨床状態に及ぼす影響(Impact of Intrarenal Hemodynamics on Clinical Status in Adults with Complex Congenital Heart Disease after Biventricular Repair)

    武本 梨佳, 杜 徳尚, 高谷 陽一, 横濱 ふみ, 中山 理絵, 赤木 禎治, 内田 治仁, 大塚 文男, 伊藤 浩

    日本循環器学会学術集会抄録集   86回   MPJ08 - 1   2022.3

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  • 心不全患者におけるShear Wave Elastographyを用いた肝うっ血評価法

    中山 理絵, 高谷 陽一, 中村 一文, 杜 徳尚, 伊藤 浩

    日本内科学会雑誌   111 ( 臨増 )   160 - 160   2022.2

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  • 心房中隔欠損症患者における閉鎖治療前後での肝うっ血評価

    中山 理絵, 高谷 陽一, 赤木 禎治, 武本 梨佳, 杜 徳尚, 伊藤 浩

    日本成人先天性心疾患学会雑誌   11 ( 1 )   197 - 197   2022.1

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  • 当院における経カテーテル卵円孔開存閉鎖術の成績

    三木 崇史, 赤木 禎治, 中山 理絵, 高谷 陽一, 中川 晃志, 伊藤 浩

    日本成人先天性心疾患学会雑誌   11 ( 1 )   253 - 253   2022.1

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  • Investigation of Morphology of Patent Foramen Ovale in Patients With Paradoxical Embolism Based on Age and Cardiac Function

    中山理絵, 高谷陽一, 赤木禎治, 三木崇史, 横濱ふみ, 中川晃志, 杜徳尚, 伊藤浩

    超音波医学 Supplement   49   2022

  • 【経食道心エコーの新ルール!】心房中隔欠損精査のルール

    中山 理絵, 高谷 陽一

    心エコー   22 ( 6 )   568 - 574   2021.6

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  • 心不全ステージにおけるshear wave elastographyを用いた肝障害の評価

    中山 理絵, 高谷 陽一, 中村 一文, 杜 徳尚, 伊藤 浩

    超音波医学   48 ( Suppl. )   S618 - S618   2021.4

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  • 【卵円孔開存の問題と新しい治療】卵円孔開存のエコー診断 ハイリスクPFOとは

    中山 理絵

    医学のあゆみ   276 ( 4 )   270 - 275   2021.1

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    卵円孔開存(PFO)を介した奇異性脳塞栓症に対して、カテーテル閉鎖術が保険適用となった。カテーテル閉鎖術は薬物治療と比較し、再発予防に有用であると報告されており、今後塞栓源不明の脳塞栓症患者に対して、PFO診断を確実に行う必要がでてきた。安静時にはPFOを介した短絡血流を認めない症例が多く、経胸壁心エコー図ではバルサルバ手技を用いたバブルテストによるスクリーニングを行う。また、PFOのなかでもハイリスクとされる形態を有する患者ではカテーテル閉鎖術が効果的であり、治療選択の際に重要なポイントとなる。そのため、経食道心エコー図ではPFOの有無だけではなく、PFOの形態評価を行うことが重要である。本稿では、エコーによるPFO診断法や診断のコツ、さらに注目すべきPFO形態について概説する。(著者抄録)

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    Other Link: https://search.jamas.or.jp/default/link?pub_year=2021&ichushi_jid=J00060&link_issn=&doc_id=20210125020004&doc_link_id=issn%3D0039-2359%26volume%3D276%26issue%3D4%26spage%3D270&url=http%3A%2F%2Fwww.pieronline.jp%2Fopenurl%3Fissn%3D0039-2359%26volume%3D276%26issue%3D4%26spage%3D270&type=PierOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00005_2.gif

  • 経胸壁心エコー図のPFO診断

    高谷陽一, 渡辺修久, 中山理絵, 杜徳尚, 三木崇史, 中川晃志, 赤木禎治, 伊藤浩

    日本心血管画像動態学会プログラム・抄録集   31st (CD-ROM)   2021

  • 心臓CTによる卵円孔開存症の診断能についての検討

    三木崇史, 中川晃志, 市川啓之, 水野智文, 中山理絵, 浅田早央莉, 川田哲史, 高谷陽一, 宮本真和, 三好亨, 赤木禎治, 伊藤浩

    日本心血管画像動態学会プログラム・抄録集   31st (CD-ROM)   2021

  • Shear Wave Imagingを用いた心筋性状評価

    中山 理絵, 高谷 陽一, 中村 一文, 網岡 尚文, 大塚 寛昭, 赤木 達, 吉田 賢司, 三好 享, 伊藤 浩

    超音波医学   47 ( Suppl. )   S245 - S245   2020.11

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  • Shear wave elastographyによるモノクロタリン誘発性肺高血圧ラット心筋の評価(Evaluation of Myocardium Using Shear Wave Elastography in Monocrotaline-induced Pulmonary Hypertension Rat Heart)

    中山 理絵, 高谷 陽一, 中村 一文, 網岡 尚史, 木村 朋生, 赤木 達, 吉田 賢司, 伊藤 浩

    日本循環器学会学術集会抄録集   84回   PJ4 - 3   2020.7

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  • 右室拡大が心房中隔欠損閉鎖術の適応に及ぼす影響(Impact of Right Ventricular Dilatation on an Indication for Atrial Septal Defect Closure)

    中山 理絵, 高谷 陽一, 赤木 禎治, 三木 崇史, 中川 晃志, 杜 徳尚, 伊藤 浩

    日本循環器学会学術集会抄録集   84回   OJ32 - 9   2020.7

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  • 【さらに!インターベンションに役立つ心エコー】卵円孔開存閉鎖デバイスの有用性

    中山 理絵, 高谷 陽一

    心エコー   21 ( 6 )   567 - 573   2020.6

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  • structural heart diseaseのカテーテル治療(第3回) 心房中隔欠損閉鎖システムによる心房中隔欠損症カテーテル治療

    中山 理絵, 杜 徳尚

    超音波検査技術   45 ( 3 )   291 - 299   2020.6

  • PH合併先天性心疾患に対するTreat and Repairについて

    高谷陽一, 赤木禎治, 中川晃志, 中山理絵, 三木崇史, 伊藤浩

    日本心不全学会学術集会プログラム・抄録集   24th (CD-ROM)   2020

  • 【肺高血圧症-診断・治療の最新動向-】肺高血圧症の診断 心エコー診断

    中山 理絵, 伊藤 浩

    日本臨床   77 ( 7 )   1095 - 1101   2019.7

  • Shear Wave Imagingを用いた肝うっ血評価

    中山 理絵, 高谷 陽一, 渡邉 修久, 杜 徳尚, 中村 一文, 伊藤 浩

    超音波医学   46 ( Suppl. )   S586 - S586   2019.4

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  • 片頭痛に関連する卵円孔開存と比較した潜因性脳卒中に関連する高リスク卵円孔開存の特定(Identification of High-Risk Patent Foramen Ovale Associated with Cryptogenic Stroke in Comparison with Migraine)

    中山 理絵, 高谷 陽一, 赤木 禎治, 池田 まどか, 渡邉 修久, 中川 晃志, 杜 徳尚, 伊藤 浩

    日本循環器学会学術集会抄録集   83回   OJ08 - 9   2019.3

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  • 心房中隔欠損症患者における右室容積とexercise capacityの関連性について(Relationship between right ventricular volume and exercise capacity in patients with atrial septal defect)

    中山 理絵, 高谷 陽一, 赤木 禎治, 渡辺 修久, 池田 まどか, 中川 晃志, 杜 徳尚, 伊藤 浩

    日本成人先天性心疾患学会雑誌   8 ( 1 )   111 - 111   2019.1

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  • カテーテルインターベンションの最新治療 卵円孔開存に対するカテーテル治療(Transcatheter Closure of Patent Foramen Ovale)

    高谷 陽一, 赤木 禎治, 中川 晃志, 中山 理絵, 三木 崇史, 伊藤 浩

    日本成人先天性心疾患学会雑誌   8 ( 1 )   90 - 90   2019.1

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  • 経胸壁心エコー図によるPFO診断における腹部圧迫法とバブルカットオフ値の有用性(Importance of Abdominal Compression Valsalva Maneuver and Microbubble Cutoff of Transthoracic Echocardiography for Detecting Patent Foramen Ovate)

    高谷 陽一, 渡辺 修久, 池田 まどか, 赤木 禎治, 中川 晃志, 中山 理絵, 杜 徳尚, 伊藤 浩

    日本成人先天性心疾患学会雑誌   8 ( 1 )   111 - 111   2019.1

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  • 症候性心不全を伴う成人ASDへの対応

    赤木禎治, 高谷陽一, 中川晃志, 三木崇史, 中山理絵, 杜徳尚, 伊藤浩

    日本心不全学会学術集会プログラム・抄録集   23rd   2019

  • Fallot四徴症心内修復術後25年で心不全症状が出現した1例

    中山 理絵, 高谷 陽一, 伊藤 浩

    心エコー   19 ( 6 )   624 - 628   2018.6

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  • 血行再建後の末梢動脈疾患患者に対する非監視下運動療法の効果

    木元 朗, 中山 理絵, 原賀 泰誠, 戸田 洋伸, 三好 亨

    日本下肢救済・足病学会誌   10 ( 1 )   77 - 77   2018.6

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  • Evaluation of incidence and severity of patent foramen ovale in patients with migraine

    赤木禎治, 高谷陽一, 中山理絵, 中川晃志, 三木崇史, 伊藤浩

    日本頭痛学会誌   45 ( 2 (Web) )   2018

  • 卵円孔開存の診断における経胸壁心エコー図の有用性

    高谷陽一, 渡辺修久, 池田まどか, 中山理絵, 杜徳尚, 中川晃志, 赤木禎治, 伊藤浩

    日本心血管脳卒中学会学術集会プログラム・抄録集   5th   2018

  • 【知って役立つ心筋症診療のポイント:二次性心筋疾患のすべて】心筋緻密化障害

    中山 理絵, 伊藤 浩

    成人病と生活習慣病   47 ( 10 )   1265 - 1271   2017.10

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    心筋緻密化障害は、左室心筋が心外膜側の緻密層と心内膜側の疎な肉柱層の二層構造を呈する先天性の心筋症である。その診断には心エコー検査や心臓MRIが有用であり、心室壁の過剰な網目状の肉柱形成による深い間隙が特徴である。本疾患が進行すると拡張型心筋症との鑑別が難しくなる。心不全、壁在血栓による塞栓症、不整脈が合併する。臨床経過として新生児期、乳児期に重篤な心不全症状で発症し、急激な経過をたどる例から、無症状で成人になって初めて診断される例まで存在する。一般的に経過とともに心機能低下が進行し、長期予後不良の疾患であるため早期発見とその後の適切な治療が重要とされる。(著者抄録)

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    Other Link: https://search.jamas.or.jp/default/link?pub_year=2017&ichushi_jid=J03723&link_issn=&doc_id=20171113140009&doc_link_id=%2Faq9seijd%2F2017%2F004710%2F009%2F1265-1272%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Faq9seijd%2F2017%2F004710%2F009%2F1265-1272%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • 閉塞したsaphenous vein graftを使用したretrograde approachにて治療し得た、左回旋枝CTOの一例

    梁 泰成, 具 滋樹, 西山 裕善, 小笹 祐, 中山 理絵, 谷和 孝昭, 石原 昭三

    日本心血管インターベンション治療学会抄録集   25回   MO246 - MO246   2016.7

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  • Retrograde approachでの再灌流後に冠動脈穿孔を認めた2症例

    石原 昭三, 具 滋樹, 西山 裕善, 梁 泰成, 小笹 祐, 中山 理絵, 谷和 孝昭

    日本心血管インターベンション治療学会抄録集   25回   MO245 - MO245   2016.7

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  • たこつぼ心筋障害にて発見された副腎外褐色細胞腫の一例

    野坂 和正, 小林 泰幸, 高木 航, 中山 理絵, 大河 啓介, 梶谷 昌史, 岩本 睦, 土井 正行, 武田 光, 中村 聡子, 間野 正平

    香川県内科医会誌   49   54 - 59   2013.8

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    71歳男性。高血圧と糖尿病の既往あり。平成24年5月胸痛を主訴に近医より急性心筋梗塞の疑いにて当院に紹介となる。心電図で胸部誘導に広範なST上昇を認め、エコーで前壁の壁運動低下を認めたため急性冠症候群疑いにて冠動脈造影を施行した。冠動脈には有意な狭窄および閉塞を認めず、左室造影で心尖部に限局した壁運動異常を認めたためたこつぼ心筋症と診断した。経過中二次性高血圧の精査目的で腹部エコーを施行したところ後腹膜に6cm大の腫瘤を認め、血中アドレナリン値を測定したところ著明に上昇していた。褐色細胞腫を疑い同年7月切除手術を施行した。術後の病理では副腎外腫瘍であったが、表現型は褐色細胞腫と同等であった。術後血中アドレナリン値は正常化し、高血圧のみならず糖尿病も改善を認めた。褐色細胞腫によるたこつぼ心筋障害は文献上散見されるが臨床的には珍しいため報告する。(著者抄録)

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  • 腎動脈血栓閉塞による急性腎不全に対して経皮的腎動脈形成術(PTRA)が著効した腎動脈狭窄症の1例

    岩本 康平, 山崎 康司, 岩本 睦, 伊勢 奈津美, 光中 弘毅, 高木 航, 中山 理絵, 野坂 和正, 大河 啓介, 梶谷 昌史, 土井 正行, 武田 光

    香川県立中央病院医学雑誌   32   22 - 27   2013.3

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    症例は80歳代男性。高血圧と慢性腎不全にて近医通院中、急速な腎機能悪化と腹部大動脈瘤を認めたために当院に紹介、精査加療目的に入院となった。高度腎機能悪化に対して血液透析を開始するとともに、腹部大動脈瘤内に壁在血栓を認め持続ヘパリン投与を開始した。腹部造影CTにて左腎高度萎縮、右腎動脈起始部の狭窄、主幹部の血栓閉塞が疑われ、入院第7病日に腎動脈造影検査を施行し、右腎動脈起始部に90%狭窄と腎動脈中間部に血栓による閉塞を認めたために、経皮的腎動脈形成術(PTRA)を施行した。PTRA後、尿量の増加と腎機能の改善を認め第14病日に透析を離脱した。高度腎動脈狭窄による血流低下が血栓形成の主因と考えられたが、側副血行路による血流があり腎梗塞に至らなかったことが腎機能回復につながったと考えられる。(著者抄録)

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  • 大動脈無冠尖からのアブレーションを要したHis束近傍起源心房頻拍の1例

    大河 啓介, 高木 航, 中山 理絵, 野坂 和正, 梶谷 昌史, 岩本 睦, 土井 正行, 武田 光

    香川県医師会誌   65 ( 特別 )   68 - 68   2012.9

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  • 慢性腎不全の急性増悪に対し経皮的腎動脈形成術が著効した一例

    岩本 睦, 高木 航, 中山 理絵, 野坂 和正, 大河 啓介, 梶谷 昌史, 土井 正行, 武田 光, 岩本 康平, 伊勢 奈津美, 光中 弘毅, 山崎 康司

    香川県医師会誌   65 ( 特別 )   68 - 68   2012.9

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  • MTX関連リンパ増殖性疾患(MTX-LPD)の4例

    中山 理絵, 脇 正人, 川上 公宏, 中村 聡子

    香川県内科医会誌   46   133 - 134   2010.6

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  • 当院におけるMTX関連リンパ増殖性疾患(MTX-LPD)の4例

    中山 理絵, 脇 正人, 小橋 嵩平, 光中 弘毅, 秋山 賢次, 中村 聡子, 川上 公宏

    香川県立中央病院医学雑誌   29   8 - 12   2010.3

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    MTX関連リンパ増殖性疾患の4例(男2例、女2例、60~78歳)の診断・治療成績を報告した。メトトレキサート(MTX)投与開始からリンパ腫発症までの期間は36ヵ月~98ヵ月、投与総量は864mg~2352mgで、腫瘍壊死因子(TNF)α阻害薬は2例に投与されていた。病理診断は4例とも非ホジキンリンパ腫びまん性大細胞型であり、臨床経過からMTX関連リンパ増殖性疾患の診断とした。初期治療はMTXとTNFα阻害薬の休薬を行った。EBウイルスがin situ hybridizationで確認された2例中1例のみ腫瘍の消褪を認め、その他3例は腫瘍増大のためリツキサンとCHOP療法を施行し腫瘍は縮小した。リンパ腫治療後の関節リウマチはステロイド少量によりコントロールできている。

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  • Cardiovascular Medicine(Core Clinical Practice) (2024academic year) special  - その他