Updated on 2025/07/06

写真a

 
UCHIDA Daisuke
 
Organization
Scheduled update Special-Appointment Associate Professor
Position
Special-Appointment Associate Professor
External link

Degree

  • 医学博士 ( 岡山大学大学院医歯薬学総合研究科 )

Research Interests

  • Gene therapy

  • Gastroenterological endoscopy

  • Gastroenterology

  • レギュラトリーサイエンス

Research Areas

  • Life Science / Tumor diagnostics and therapeutics

  • Life Science / Gastroenterology  / Gastroenterology

  • Life Science / Medical technology assessment  / レギュラトリーサイエンス

Education

  • Okayama University    

    2011.4 - 2014.9

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  • Okayama University   医学部   医学科

    2000.4 - 2006.3

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Research History

  • Okayama University   Okayama University Hospital   Associate Professor

    2025.7

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  • Okayama University   Okayama University Hospital   Lecturer

    2023.1 - 2025.7

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  • 東京医科大学病院   兼任講師

    2022.12

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  • Okayama University   Okayama University Hospital   Assistant Professor

    2022.4 - 2023.1

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  • 医薬品医療機器総合機構   審査専門員(臨床医学担当)

    2020.4 - 2022.3

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  • Okayama University   新医療研究開発センター   Assistant Professor

    2018.6 - 2020.3

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  • Okayama University   消化器内科

    2011.4 - 2018.5

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  • 広島市立広島市民病院   内科後期研修医

    2008.4 - 2011.3

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  • 広島市立広島市民病院   初期臨床研修医

    2006.4 - 2008.3

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Committee Memberships

  • 独立行政法人医薬品医療機器総合機構   外部専門委員  

    2022.4   

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Papers

  • Effectiveness of data-augmentation on deep learning in evaluating rapid on-site cytopathology at endoscopic ultrasound-guided fine needle aspiration. International journal

    Yuki Fujii, Daisuke Uchida, Ryosuke Sato, Taisuke Obata, Matsumi Akihiro, Kazuya Miyamoto, Kosaku Morimoto, Hiroyuki Terasawa, Tatsuhiro Yamazaki, Kazuyuki Matsumoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hironari Kato, Hirofumi Inoue, Ten Cho, Takayoshi Tanimoto, Akimitsu Ohto, Yoshiro Kawahara, Motoyuki Otsuka

    Scientific reports   14 ( 1 )   22441 - 22441   2024.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    Rapid on-site cytopathology evaluation (ROSE) has been considered an effective method to increase the diagnostic ability of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA); however, ROSE is unavailable in most institutes worldwide due to the shortage of cytopathologists. To overcome this situation, we created an artificial intelligence (AI)-based system (the ROSE-AI system), which was trained with the augmented data to evaluate the slide images acquired by EUS-FNA. This study aimed to clarify the effects of such data-augmentation on establishing an effective ROSE-AI system by comparing the efficacy of various data-augmentation techniques. The ROSE-AI system was trained with increased data obtained by the various data-augmentation techniques, including geometric transformation, color space transformation, and kernel filtering. By performing five-fold cross-validation, we compared the efficacy of each data-augmentation technique on the increasing diagnostic abilities of the ROSE-AI system. We collected 4059 divided EUS-FNA slide images from 36 patients with pancreatic cancer and nine patients with non-pancreatic cancer. The diagnostic ability of the ROSE-AI system without data augmentation had a sensitivity, specificity, and accuracy of 87.5%, 79.7%, and 83.7%, respectively. While, some data-augmentation techniques decreased diagnostic ability, the ROSE-AI system trained only with the augmented data using the geometric transformation technique had the highest diagnostic accuracy (88.2%). We successfully developed a prototype ROSE-AI system with high diagnostic ability. Each data-augmentation technique may have various compatibilities with AI-mediated diagnostics, and the geometric transformation was the most effective for the ROSE-AI system.

    DOI: 10.1038/s41598-024-72312-3

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  • 【膵・胆道癌の発生・進展メカニズムを探る】膵癌の薬剤耐性メカニズム

    寺澤 裕之, 堤 康一郎, 原田 圭, 服部 直, 菊池 達也, 小幡 泰介, 佐藤 亮介, 織田 崇志, 松三 明宏, 宮本 和也, 藤井 佑樹, 赤穂 宗一郎, 内田 大輔, 松本 和幸, 堀口 繁, 大塚 基之

    胆と膵   45 ( 8 )   801 - 806   2024.8

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    Language:Japanese   Publisher:医学図書出版(株)  

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  • 【膵・胆道癌の発生・進展メカニズムを探る】胆道癌の薬剤耐性メカニズム

    堤 康一郎, 小幡 泰介, 織田 崇志, 松三 明宏, 宮本 和也, 寺澤 裕之, 藤井 佑樹, 内田 大輔, 松本 和幸, 堀口 繁, 大塚 基之

    胆と膵   45 ( 8 )   857 - 862   2024.8

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    Language:Japanese   Publisher:医学図書出版(株)  

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  • 【膵・胆道癌の発生・進展メカニズムを探る】胆道癌の薬剤耐性メカニズム

    堤 康一郎, 小幡 泰介, 織田 崇志, 松三 明宏, 宮本 和也, 寺澤 裕之, 藤井 佑樹, 内田 大輔, 松本 和幸, 堀口 繁, 大塚 基之

    胆と膵   45 ( 8 )   857 - 862   2024.8

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  • 【膵・胆道癌の発生・進展メカニズムを探る】膵癌の薬剤耐性メカニズム

    寺澤 裕之, 堤 康一郎, 原田 圭, 服部 直, 菊池 達也, 小幡 泰介, 佐藤 亮介, 織田 崇志, 松三 明宏, 宮本 和也, 藤井 佑樹, 赤穂 宗一郎, 内田 大輔, 松本 和幸, 堀口 繁, 大塚 基之

    胆と膵   45 ( 8 )   801 - 806   2024.8

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  • 膵EUS-FNA診断の功罪 嚢胞・壊死を伴う膵管癌に対するFNA/B合併症リスクの検討

    寺澤 裕之, 松本 和幸, 田中 健大, 友田 健, 小川 泰司, 石原 裕基, 菊池 達也, 小幡 泰介, 織田 崇志, 松三 明宏, 宮本 和也, 森本 光作, 藤井 佑樹, 山崎 辰洋, 内田 大輔, 堀口 繁, 堤 康一郎, 加藤 博也, 大塚 基之

    膵臓   39 ( 3 )   A234 - A234   2024.7

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    Language:Japanese   Publisher:(一社)日本膵臓学会  

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  • 後期高齢者におけるIPMNの治療移行割合及び長期経過についての検討

    宮本 和也, 松本 和幸, 服部 直, 小幡 泰介, 佐藤 亮介, 織田 崇志, 菊池 達也, 松三 明宏, 森本 光作, 寺澤 裕之, 藤井 佑樹, 内田 大輔, 堀口 繁, 堤 康一郎, 加藤 博也, 大塚 基之

    膵臓   39 ( 3 )   A425 - A425   2024.7

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  • Virtual indigo carmine chromoendoscopy images: A novel modality for peroral cholangioscopy using artificial intelligence technology (with video). International journal

    Ryosuke Sato, Kazuyuki Matsumoto, Hideaki Kinugasa, Masahiro Tomiya, Takayoshi Tanimoto, Akimitsu Ohto, Kei Harada, Nao Hattori, Taisuke Obata, Akihiro Matsumi, Kazuya Miyamoto, Kosaku Morimoto, Hiroyuki Terasawa, Yuki Fujii, Daisuke Uchida, Koichiro Tsutsumi, Shigeru Horiguchi, Hironari Kato, Yoshiro Kawahara, Motoyuki Otsuka

    Gastrointestinal endoscopy   2024.6

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    BACKGROUND AND AIMS: Accurately diagnosing biliary strictures is crucial for surgical decisions, and although peroral cholangioscopy (POCS) aids in visual diagnosis, diagnosing malignancies or determining lesion margins via this route remains challenging. Indigo carmine is commonly used to evaluate lesions during gastrointestinal endoscopy. We aimed to establish the utility of virtual indigo carmine chromoendoscopy (VICI) converted from POCS images using artificial intelligence. METHODS: This single-center, retrospective study analyzed 40 patients with biliary strictures who underwent POCS using white light imaging (WLI) and narrow-band imaging (NBI). A "cycle-consistent adversarial network" (CycleGAN) was used to convert the WLI into VICI of POCS images. Three experienced endoscopists evaluated WLI, NBI, and VICI via POCS in all patients. The primary outcome was the visualization quality of surface structures, surface microvessels, and lesion margins. The secondary outcome was diagnostic accuracy. RESULTS: VICI showed superior visualization of the surface structures and lesion margins compared with WLI (P<0.001) and NBI (P<0.001). The diagnostic accuracies were 72.5%, 87.5%, and 90.0% in WLI alone, WLI and VICI simultaneously, and WLI and NBI simultaneously, respectively. WLI and VICI simultaneously tended to result in higher accuracy than WLI alone (P=0.083) and the results were not significantly different from WLI and NBI simultaneously (P=0.65). CONCLUSIONS: VICI in POCS proved valuable for visualizing surface structures and lesion margins and contributed to higher diagnostic accuracy comparable to NBI. In addition to NBI, VICI may be a novel supportive modality for POCS.

    DOI: 10.1016/j.gie.2024.06.013

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  • Detection of residual stones by peroral direct cholangioscopy in patients with intrahepatic stones after hepaticojejunostomy: A prospective study (with video). International journal

    Kazuyuki Matsumoto, Hironari Kato, Akihiro Matsumi, Kazuya Miyamoto, Kosaku Morimoto, Yuki Fujii, Ryosuke Sato, Nao Hattori, Taisuke Obata, Hiroyuki Terasawa, Daisuke Uchida, Shigeru Horiguchi, Koichiro Tsutsumi, Motoyuki Otsuka

    Gastrointestinal endoscopy   100 ( 3 )   457 - 463   2024.4

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    BACKGROUND AND AIMS: The difficulty of radiographic confirmation of the presence of stones remains a challenge in the treatment of intrahepatic bile duct (IHBD) stones in patients after hepaticojejunostomy (HJ). Peroral direct cholangioscopy (PDCS) enables direct observation of the bile duct and is useful for detecting and removing residual stones; however, its effectiveness is not clearly established in this clinical context. METHODS: This single-center, single-arm, prospective study included 44 patients with IHBD who underwent bowel reconstruction with HJ during the study period. Stone removal was performed by short-type double-balloon enteroscopy (DBE). Following balloon-occluded cholangiography, the DBE was exchanged for an ultraslim endoscope through the balloon overtube for PDCS. The primary endpoint was the rate of residual stones detected by PDCS. Secondary endpoints were success rate of PDCS, residual stone removal with PDCS, procedure time for PDCS, procedure-related adverse events, and stone recurrence rate. RESULTS: PDCS was successful in 39/44 patients (89%), among whom residual stones were detected in 16 (41%) (95% CI: 28%-54%). Twelve patients (75%) had residual stones <5 mm. Stone removal was successful in 15 (94%) patients and median procedure time for PDCS was 16 (IQR: 10-26) min. The rate of procedure-related adverse events was 7% (3/44), all of which improved with conservative treatment. During median follow-up of 2.1 years (IQR: 1.4-3.3), the overall probability of recurrence-free status at 1, 2, and 3 years was 100%, 92%, and 86%, respectively. CONCLUSIONS: PDCS is a safe and effective procedure for complete stone removal in patients with IHBD stones after HJ.

    DOI: 10.1016/j.gie.2024.04.014

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  • 結節を有するIPMNの良悪性診断における新規TIC解析プログラムを用いた造影EUSの有用性

    宮本 和也, 内田 大輔, 服部 直, 小幡 泰介, 佐藤 亮介, 織田 崇志, 菊池 達也, 松三 明宏, 森本 光作, 寺澤 裕之, 藤井 佑樹, 松本 和幸, 堀口 繁, 堤 康一郎, 加藤 博也, 大塚 基之

    Gastroenterological Endoscopy   66 ( Suppl.1 )   977 - 977   2024.4

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    Language:Japanese   Publisher:(一社)日本消化器内視鏡学会  

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  • MicroRNA-34a-5p: A pivotal therapeutic target in gallbladder cancer. International journal

    Takashi Oda, Koichiro Tsutsumi, Taisuke Obata, Eijiro Ueta, Tatsuya Kikuchi, Soichiro Ako, Yuki Fujii, Tatsuhiro Yamazaki, Daisuke Uchida, Kazuyuki Matsumoto, Shigeru Horiguchi, Hironari Kato, Hiroyuki Okada, Ryota Chijimatsu, Motoyuki Otsuka

    Molecular therapy. Oncology   32 ( 1 )   200765 - 200765   2024.3

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    Gallbladder cancer incidence has been increasing globally, and it remains challenging to expect long prognosis with the current systemic chemotherapy. We identified a novel nucleic acid-mediated therapeutic target against gallbladder cancer by using innovative organoid-based gallbladder cancer models generated from KrasLSL-G12D/+; Trp53f/f mice. Using comprehensive microRNA expression analyses and a bioinformatics approach, we identified significant microRNA-34a-5p downregulation in both murine gallbladder cancer organoids and resected human gallbladder cancer specimens. In three different human gallbladder cancer cell lines, forced microRNA-34a-5p expression inhibited cell proliferation and induced cell-cycle arrest at the G1 phase by suppressing direct target (CDK6) expression. Furthermore, comprehensive RNA sequencing revealed the significant enrichment of gene sets related to the cell-cycle regulators after microRNA-34a-5p expression in gallbladder cancer cells. In a murine xenograft model, locally injected microRNA-34a-5p mimics significantly inhibited gallbladder cancer progression and downregulated CDK6 expression. These results provide a rationale for promising therapeutics against gallbladder cancer by microRNA-34a-5p injection, as well as a strategy to explore therapeutic targets against cancers using organoid-based models, especially for those lacking useful genetically engineered murine models, such as gallbladder cancer.

    DOI: 10.1016/j.omton.2024.200765

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  • 経口胆道鏡検査におけるAIを用いた色素内視鏡画像への疑似変換

    佐藤 亮介, 松本 和幸, 冨谷 昌弘, 谷本 太郁由, 大戸 彰三, 原田 圭, 服部 直, 小幡 泰介, 松三 明宏, 宮本 和也, 森本 光作, 寺澤 裕之, 藤井 佑樹, 内田 大輔, 衣笠 秀明, 堤 康一郎, 堀口 繁, 加藤 博也, 河原 祥朗, 大塚 基之

    日本消化器病学会雑誌   121 ( 臨増総会 )   A356 - A356   2024.3

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  • AIを用いた消化器疾患の診断・治療への応用 内視鏡画像を用いた早期胃癌の深達度診断支援プログラムの性能

    平田 翔一郎, 濱田 健太, 河原 祥朗, 倉岡 紗樹子, 内田 大輔, 河野 吉泰, 岩室 雅也, 川野 誠司, 大塚 基之

    日本消化器病学会雑誌   121 ( 臨増総会 )   A36 - A36   2024.3

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  • 経口胆道鏡検査におけるAIを用いた色素内視鏡画像への疑似変換

    佐藤 亮介, 松本 和幸, 冨谷 昌弘, 谷本 太郁由, 大戸 彰三, 原田 圭, 服部 直, 小幡 泰介, 松三 明宏, 宮本 和也, 森本 光作, 寺澤 裕之, 藤井 佑樹, 内田 大輔, 衣笠 秀明, 堤 康一郎, 堀口 繁, 加藤 博也, 河原 祥朗, 大塚 基之

    日本消化器病学会雑誌   121 ( 臨増総会 )   A356 - A356   2024.3

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  • MicroRNA-451a inhibits gemcitabine-refractory biliary tract cancer progression by suppressing the MIF-mediated PI3K/AKT pathway. International journal

    Taisuke Obata, Koichiro Tsutsumi, Eijiro Ueta, Takashi Oda, Tatsuya Kikuchi, Soichiro Ako, Yuki Fujii, Tatsuhiro Yamazaki, Daisuke Uchida, Kazuyuki Matsumoto, Shigeru Horiguchi, Hironari Kato, Hiroyuki Okada, Motoyuki Otsuka

    Molecular therapy. Nucleic acids   34   102054 - 102054   2023.12

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    Gemcitabine is an effective chemotherapeutic agent for biliary tract cancers (BTCs), including gallbladder cancer (GBC) and cholangiocarcinoma (CCA). However, few other effective agents are currently available, particularly for GEM-refractory BTCs. We previously identified microRNA-451a (miR-451a) as a potential therapeutic target in GBC. To elucidate the antineoplastic effects of miR-451a and its underlying mechanisms, we transfected miR-451a into GBC, gemcitabine-resistant GBC (GR-GBC), and gemcitabine-resistant CCA (GR-CCA) cell lines. Furthermore, mimicking in vivo conditions, tumorigenic GBC organoids and three-dimensional (3D) cell culture systems were employed to investigate the anti-proliferative effects of miR-451a on BTCs, and its effect on stem cell properties. We found that miR-451a significantly inhibited cell proliferation, induced apoptosis, and reduced chemoresistant phenotypes, such as epithelial-mesenchymal transition, in both GBC and GR-GBC. The principal mechanism is probably the negative regulation of the phosphatidylinositol 3-kinase/AKT pathway, partially accomplished by directly downregulating macrophage migration inhibitory factor. The Gene Expression Omnibus database revealed that miR-451a was the most significantly downregulated microRNA in CCA tissues. The introduction of miR-451a resulted in similar antineoplastic effects in GR-CCA. Furthermore, miR-451a reduced cell viability in 3D spheroid models and tumorigenic GBC organoids. These findings suggest that the supplementation of miR-451a is a potential treatment strategy for GEM-refractory BTCs.

    DOI: 10.1016/j.omtn.2023.102054

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  • Successful removal of a proximally migrated pancreatic stent using a novel device delivery system. International journal

    Akihiro Matsumi, Kazuyuki Matsumoto, Daisuke Uchida, Shigeru Horiguchi, Koichiro Tsutsumi, Hironari Kato, Motoyuki Otsuka

    Endoscopy   55 ( S 01 )   E641-E642   2023.12

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    DOI: 10.1055/a-2063-3408

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  • Usefulness of red dichromatic imagining for peroral cholangioscopy. International journal

    Kazuyuki Matsumoto, Yuki Fujii, Daisuke Uchida, Shigeru Horiguchi, Koichiro Tsutsumi, Hironari Kato

    Endoscopy   55 ( S 01 )   E264-E265   2023.12

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    DOI: 10.1055/a-1966-0534

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  • Usefulness of the artificial intelligence-mediated virtual chromoendoscopy in peroral cholangioscopy. International journal

    Ryosuke Sato, Kazuyuki Matsumoto, Hideaki Kinugasa, Daisuke Uchida, Shigeru Horiguchi, Hironari Kato, Motoyuki Otsuka

    Endoscopy   55 ( S 01 )   E971-E972   2023.12

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    DOI: 10.1055/a-2142-4555

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  • 膵神経内分泌腫瘍の治療中にうっ血性左側結腸炎を発症した1例

    佐藤 亮介, 堀口 繁, 小幡 泰介, 松三 明宏, 宮本 和也, 森本 光作, 寺澤 裕之, 藤井 佑樹, 山崎 辰洋, 内田 大輔, 松本 和幸, 堤 康一郎, 加藤 博也, 大塚 基之

    日本消化器病学会中国支部例会・日本消化器内視鏡学会中国支部例会プログラム・抄録集   120回・131回   84 - 84   2023.11

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  • ロボット支援下膵頭十二指腸切除術後の捻転を伴う輸入脚症候群に対して内視鏡的整復を行った1例

    原田 圭, 藤井 佑樹, 小幡 泰介, 佐藤 亮介, 松三 明宏, 宮本 和也, 森本 光作, 寺澤 裕之, 山崎 辰洋, 内田 大輔, 松本 和幸, 堀口 繁, 堤 康一郎, 加藤 博也, 大塚 基之

    日本消化器病学会中国支部例会・日本消化器内視鏡学会中国支部例会プログラム・抄録集   120回・131回   112 - 112   2023.11

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  • 特発性肺線維症に対する肺移植後に重症膵炎を発症し、診断に苦慮した膵頭部癌の一例

    矢杉 賢吾, 堀口 しげる, 小幡 泰介, 佐藤 亮介, 織田 崇志, 菊池 達也, 松三 明宏, 宮本 和也, 森本 光作, 寺澤 裕之, 藤井 祐樹, 山崎 辰洋, 内田 大輔, 松本 和幸, 堤 康一郎, 加藤 博也, 大塚 基之

    日本消化器病学会中国支部例会・日本消化器内視鏡学会中国支部例会プログラム・抄録集   120回・131回   85 - 85   2023.11

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  • Cysts or necrotic components in pancreatic ductal adenocarcinoma is associated with the risk of EUS-FNA/B complications including needle tract seeding. International journal

    Hiroyuki Terasawa, Kazuyuki Matsumoto, Takehiro Tanaka, Takeshi Tomoda, Taiji Ogawa, Yuki Ishihara, Tatsuya Kikuchi, Taisuke Obata, Takashi Oda, Akihiro Matsumi, Kazuya Miyamoto, Kosaku Morimoto, Yuki Fujii, Tatsuhiro Yamazaki, Daisuke Uchida, Shigeru Horiguchi, Koichiro Tsutsumi, Hironari Kato, Motoyuki Otsuka

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]   23 ( 8 )   988 - 995   2023.10

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    BACKGROUND: EUS-FNA/B for pancreatic ductal adenocarcinoma (PDAC) is generally considered to be safe; however, while the incidence is low, there are occurrences of complications. Among these complications, there are serious ones like needle tract seeding (NTS), and it is not known than which types of tumors have the risks of EUS-FNA/B complications. This study aimed to evaluate the risk of EUS-FNA/B complications in patients with PDAC, focusing on morphological features. METHODS: Overall, 442 patients who underwent EUS-FNA/B for solid pancreatic masses between January 2018 and May 2022 in four institutions were retrospectively surveyed. Finally, 361 patients histopathologically diagnosed with PDAC were analyzed. Among these patients, 79 tumors with cysts or necrotic components were compared with 282 tumors without cysts or necrotic components. The incidence and risk of EUS-FNA/B complications including NTS were evaluated. RESULTS: There were 9 (2.4 %) of total EUS-FNA/B complications and 3 (0.8 %) of NTS. The incidence of total complication rate and NTS in tumors with cysts or necrotic components were significantly higher than in those without cysts or necrotic components (total complication 6.3 % vs. 1.4 %, p = 0.026, NTS 3.7 % vs. 0 %, p = 0.01). The transgastric route of puncture (OR: 93.3, 95 % CI: 3.81-2284.23) and the existence of cysts or necrotic components (OR: 7.3, 95 % CI: 1.47-36.19) were risk factors for EUS-FNA/B complications identified by the multivariate analysis. CONCLUSIONS: We should pay attention to the risks of EUS-FNA/B complications, including NTS, when the tumor has cysts or necrotic components.

    DOI: 10.1016/j.pan.2023.10.018

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  • The efficacy of non-anesthesiologist-administered propofol sedation with a target-controlled infusion system during double-balloon endoscopic retrograde cholangiopancreatography. International journal

    Kazuya Miyamoto, Kazuyuki Matsumoto, Taisuke Obata, Ryosuke Sato, Akihiro Matsumi, Kosaku Morimoto, Taiji Ogawa, Hiroyuki Terasawa, Yuki Fujii, Tatsuhiro Yamazaki, Daisuke Uchida, Shigeru Horiguchi, Koichiro Tsutsumi, Hironari Kato, Motoyuki Otsuka

    BMC gastroenterology   23 ( 1 )   296 - 296   2023.9

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    BACKGROUND: The sedation method used during double-balloon endoscopic retrograde cholangiopancreatography (DB-ERCP) differs among countries and/or facilities, and there is no established method. This study aimed to evaluate the efficacy of non-anesthesiologist-administered propofol (NAAP) sedation using a target-controlled infusion (TCI) system during DB-ERCP. METHODS: This retrospective study was conducted between May 2017 and December 2020 at an academic center. One hundred and fifty-six consecutive patients who underwent DB-ERCP were sedated by gastroenterologists using diazepam (n = 77) or propofol with a TCI system (n = 79), depending on the period. The primary endpoint was a comparison of poor sedation rates between the two groups. Poor sedation was defined as a condition requiring the use of other sedative agents or discontinuation of the procedure. Secondary endpoints were sedation-related adverse events and risk factors for poor sedation. RESULTS: Poor sedation occurred significantly more often in the diazepam sedation group (diazepam sedation, n = 12 [16%] vs. propofol sedation, n = 1 [1%]; P = 0.001). Vigorous body movements (3 or 4) (diazepam sedation, n = 40 [52%] vs. propofol sedation, n = 28 [35%]; P = 0.038) and hypoxemia (< 85%) (diazepam sedation, n = 7 [9%] vs. propofol sedation, n = 1 [1%]; P = 0.027) occurred significantly more often in the diazepam sedation group. In the multivariate analysis, age < 70 years old (OR, 10.26; 95% CI, 1.57-66.98; P = 0.015), BMI ≥ 25 kg/m2 (OR, 11.96; 95% CI, 1.67-85.69; P = 0.014), and propofol sedation (OR, 0.06; 95% CI, 0.01-0.58; P = 0.015) were associated factors for poor sedation. CONCLUSIONS: NAAP sedation with the TCI system during DB-ERCP was safer and more effective than diazepam sedation.

    DOI: 10.1186/s12876-023-02936-8

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  • 先天性胆道拡張症術後の肝内胆管狭窄に対し内視鏡的胆道拡張術が有効であった一例

    宮本 和也, 加藤 博也, 小幡 泰介, 佐藤 亮介, 松三 明宏, 森本 光作, 藤井 佑樹, 山崎 辰洋, 内田 大輔, 松本 和幸, 堀口 繁, 堤 康一郎, 大塚 基之

    日本膵・胆管合流異常研究会プロシーディングス   46   76 - 76   2023.9

  • 成人における偽胆石形成のリスク因子の検討

    松三 明宏, 友田 健, 小幡 泰介, 佐藤 亮介, 宮本 和也, 森本 光作, 藤井 佑樹, 山崎 辰洋, 内田 大輔, 松本 和幸, 堀口 繁, 堤 康一郎, 加藤 博也

    胆道   37 ( 3 )   690 - 690   2023.8

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  • 結節を有するIPMNの良悪性診断における新規TIC解析プログラムを用いた造影EUSの有用性

    宮本 和也, 松本 和幸, 内田 大輔, 小幡 泰介, 佐藤 亮介, 織田 崇志, 菊池 達也, 松三 明宏, 森本 光作, 寺澤 裕之, 藤井 佑樹, 山崎 辰洋, 堀口 繁, 堤 康一郎, 加藤 博也, 大塚 基之

    膵臓   38 ( 3 )   A345 - A345   2023.7

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  • 当院における術後膵空腸吻合部狭窄に対する内視鏡治療成績の検討

    森本 光作, 山崎 辰洋, 小幡 泰介, 佐藤 亮介, 織田 崇志, 菊池 達也, 松三 明宏, 宮本 和也, 寺澤 裕之, 藤井 佑樹, 内田 大輔, 松本 和幸, 堀口 繁, 堤 康一郎, 加藤 博也, 大塚 基之

    膵臓   38 ( 3 )   A337 - A337   2023.7

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  • 高齢者における膵癌術前化学療法の有効性と安全性の検討

    藤井 佑樹, 堀口 繁, 佐藤 亮介, 小幡 泰介, 松三 明宏, 宮本 和也, 森本 光作, 寺澤 裕之, 山崎 辰洋, 内田 大輔, 松本 和幸, 堤 康一郎, 加藤 博也, 大塚 基之

    膵臓   38 ( 3 )   A316 - A316   2023.7

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  • 結節を有するIPMNの良悪性診断における新規TIC解析プログラムを用いた造影EUSの有用性

    宮本 和也, 松本 和幸, 内田 大輔, 小幡 泰介, 佐藤 亮介, 織田 崇志, 菊池 達也, 松三 明宏, 森本 光作, 寺澤 裕之, 藤井 佑樹, 山崎 辰洋, 堀口 繁, 堤 康一郎, 加藤 博也, 大塚 基之

    膵臓   38 ( 3 )   A345 - A345   2023.7

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  • 当院における術後膵空腸吻合部狭窄に対する内視鏡治療成績の検討

    森本 光作, 山崎 辰洋, 小幡 泰介, 佐藤 亮介, 織田 崇志, 菊池 達也, 松三 明宏, 宮本 和也, 寺澤 裕之, 藤井 佑樹, 内田 大輔, 松本 和幸, 堀口 繁, 堤 康一郎, 加藤 博也, 大塚 基之

    膵臓   38 ( 3 )   A337 - A337   2023.7

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  • A Comparison of the Efficacy of Plastic Stent Placement Above and Across the Sphincter of Oddi for Benign Biliary Hilar Stricture.

    Hitomi Himei, Hironari Kato, Yosuke Saragai, Yuki Fujii, Tatsuhiro Yamazaki, Daisuke Uchida, Kazuyuki Matsumoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hiroyuki Okada

    Acta medica Okayama   77 ( 3 )   291 - 299   2023.6

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    We investigated the efficacy and safety of endoscopic plastic stent (PS) placement for hilar benign biliary strictures (BBSs) and compared cases with PS placement above (inside stent, IS) and across (usual stent, US) the sphincter of Oddi. Patients who underwent initial endoscopic PS placement for hilar BBSs between August 2012 and December 2021 were retrospectively analyzed. Hilar BBSs in 88 patients were investigated. Clinical success was achieved in 81 of these cases (92.0%), including 38 patients in the IS group and 43 patients in the US group. Unexpected stent exchange (uSE) before the first scheduled PS exchange occurred in 18 cases (22.2%). The median time from first stent placement to uSE was 35 days. There was no significant difference in the rate and median time to uSE between the two groups. The rates of adverse events such as pancreatitis or cholangitis in the two groups did not significantly differ. However, the rate of difficult stent removal in the IS group (15.8%) was significantly higher than that in the US group (0%) (p=0.0019). US placement is preferable to IS placement for scheduled stent exchange, as it offers the same effectiveness and risk of adverse events with easier stent removal.

    DOI: 10.18926/AMO/65494

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  • 長期経過を追えた膵Intraductal oncocytic papillary neoplasm(IOPN)の1例

    藤井 佑樹, 佐藤 亮介, 小幡 泰介, 松三 明宏, 宮本 和也, 森本 光作, 寺澤 裕之, 山崎 辰洋, 内田 大輔, 松本 和幸, 堀口 繁, 堤 康一郎, 加藤 博也, 大塚 基之

    日本消化器病学会中国支部例会プログラム・抄録集   119回   67 - 67   2023.6

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  • 進行胆道癌に対するゲムシタビン・シスプラチン・S-1併用療法の治療成績についての検討

    小幡 泰介, 松本 和幸, 佐藤 亮介, 菊池 達也, 織田 崇志, 松三 明宏, 宮本 和也, 森本 光作, 寺澤 裕之, 藤井 佑樹, 山崎 辰洋, 内田 大輔, 堀口 繁, 堤 康一郎, 加藤 博也, 大塚 基之

    日本消化器病学会中国支部例会プログラム・抄録集   119回   65 - 65   2023.6

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  • 肝内結石に対して内視鏡用イントロデューサーEndoSheatherが有用であった1例

    佐藤 亮介, 藤井 佑樹, 小幡 泰介, 松三 明宏, 宮本 和也, 森本 光作, 寺澤 裕之, 山崎 辰洋, 内田 大輔, 松本 和幸, 堤 康一郎, 堀口 繁, 加藤 博也, 大塚 基之

    日本消化器内視鏡学会中国支部例会   130回   83 - 83   2023.6

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  • 悪性輸入脚症候群に対して超音波内視鏡下消化管ドレナージが有効であった1例

    森本 光作, 松本 和幸, 小幡 泰介, 佐藤 亮介, 織田 崇志, 菊池 達也, 松三 明宏, 宮本 和也, 寺澤 裕之, 藤井 佑樹, 山崎 辰洋, 内田 大輔, 堀口 繁, 堤 康一郎, 加藤 博也, 大塚 基之

    日本消化器内視鏡学会中国支部例会   130回   83 - 83   2023.6

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  • 肝内結石に対して内視鏡用イントロデューサーEndoSheatherが有用であった1例

    佐藤 亮介, 藤井 佑樹, 小幡 泰介, 松三 明宏, 宮本 和也, 森本 光作, 寺澤 裕之, 山崎 辰洋, 内田 大輔, 松本 和幸, 堤 康一郎, 堀口 繁, 加藤 博也, 大塚 基之

    日本消化器内視鏡学会中国支部例会   130回   83 - 83   2023.6

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  • 進行胆道癌に対するゲムシタビン・シスプラチン・S-1併用療法の治療成績についての検討

    小幡 泰介, 松本 和幸, 佐藤 亮介, 菊池 達也, 織田 崇志, 松三 明宏, 宮本 和也, 森本 光作, 寺澤 裕之, 藤井 佑樹, 山崎 辰洋, 内田 大輔, 堀口 繁, 堤 康一郎, 加藤 博也, 大塚 基之

    日本消化器病学会中国支部例会プログラム・抄録集   119回   65 - 65   2023.6

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  • 長期経過を追えた膵Intraductal oncocytic papillary neoplasm(IOPN)の1例

    藤井 佑樹, 佐藤 亮介, 小幡 泰介, 松三 明宏, 宮本 和也, 森本 光作, 寺澤 裕之, 山崎 辰洋, 内田 大輔, 松本 和幸, 堀口 繁, 堤 康一郎, 加藤 博也, 大塚 基之

    日本消化器病学会中国支部例会プログラム・抄録集   119回   67 - 67   2023.6

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  • 悪性輸入脚症候群に対して超音波内視鏡下消化管ドレナージが有効であった1例

    森本 光作, 松本 和幸, 小幡 泰介, 佐藤 亮介, 織田 崇志, 菊池 達也, 松三 明宏, 宮本 和也, 寺澤 裕之, 藤井 佑樹, 山崎 辰洋, 内田 大輔, 堀口 繁, 堤 康一郎, 加藤 博也, 大塚 基之

    日本消化器内視鏡学会中国支部例会   130回   83 - 83   2023.6

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  • 当院の胆膵内視鏡診療における放射線量の検討

    山崎 辰洋, 松本 和幸, 小幡 泰介, 松三 明宏, 宮本 和也, 森本 光作, 寺澤 裕之, 藤井 佑樹, 内田 大輔, 堀口 繁, 堤 康一郎, 加藤 博也

    Gastroenterological Endoscopy   65 ( Suppl.1 )   875 - 875   2023.4

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  • 選択的胆管seekingのためのデバイス選択

    小幡 泰介, 内田 大輔, 加藤 博也, 佐藤 亮介, 松三 明宏, 宮本 和也, 森本 光作, 寺澤 裕之, 藤井 佑樹, 山崎 辰洋, 松本 和幸, 堀口 繁, 堤 康一郎, 大塚 基之

    Gastroenterological Endoscopy   65 ( Suppl.1 )   971 - 971   2023.4

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  • 当院の胆膵内視鏡診療における放射線量の検討

    山崎 辰洋, 松本 和幸, 小幡 泰介, 松三 明宏, 宮本 和也, 森本 光作, 寺澤 裕之, 藤井 佑樹, 内田 大輔, 堀口 繁, 堤 康一郎, 加藤 博也

    Gastroenterological Endoscopy   65 ( Suppl.1 )   875 - 875   2023.4

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  • 選択的胆管seekingのためのデバイス選択

    小幡 泰介, 内田 大輔, 加藤 博也, 佐藤 亮介, 松三 明宏, 宮本 和也, 森本 光作, 寺澤 裕之, 藤井 佑樹, 山崎 辰洋, 松本 和幸, 堀口 繁, 堤 康一郎, 大塚 基之

    Gastroenterological Endoscopy   65 ( Suppl.1 )   971 - 971   2023.4

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  • Risk Factors for Ceftriaxone-Associated Pseudolithiasis in Adults. International journal

    Akihiro Matsumi, Takeshi Tomoda, Hiroyuki Terasawa, Yuki Fujii, Tatsuhiro Yamazaki, Daisuke Uchida, Kazuyuki Matsumoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hironari Kato

    Digestion   104 ( 4 )   1 - 7   2023.3

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    INTRODUCTION: Ceftriaxone (CTRX) is known to occasionally cause pseudolithiasis. This condition is often observed in children; however, few studies have reported the incidence and risk factors for CTRX-associated pseudolithiasis. METHODS: In this single-center retrospective study, we investigated the incidence of and risk factors for CTRX-associated pseudolithiasis in adults. All patients underwent computed tomography to confirm pseudolithiasis before and after CTRX administration. RESULTS: The study included 523 patients. Pseudolithiasis was detected in 89 patients (17%). Data analysis showed that abdominal area-related biliary diseases at the site of infection (odds ratio [OR] 0.19, 95% confidence interval [CI] 0.064-0.53, p = 0.0017), CTRX administration for >3 days (OR 5.0, 95% CI: 2.5-9.9, p < 0.0001), CTRX dose of 2 mg (OR 5.2, 95% CI: 2.8-9.6, p < 0.0001), fasting period >2 days (OR 3.2, 95% CI: 1.6-6.4, p = 0.0010), and estimated glomerular filtration rate <30 mL/min/1.73 m2 (OR 3.4, 95% CI: 1.6-7.5, p = 0.0022) were independent factors for pseudolithiasis. CONCLUSIONS: CTRX-associated pseudolithiasis may occur in adults and should be considered in the differential diagnosis in patients who develop abdominal pain or liver enzyme elevation after CTRX administration, particularly in patients with chronic kidney disease, in those who are fasting, in and those who receive high-dose CTRX therapy.

    DOI: 10.1159/000529522

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  • 膵癌化学療法における血中自己抗体を用いた治療効果予測の可能性

    松本 和幸, 高木 章乃夫, 高原 政宏, 小幡 泰介, 藤井 佑樹, 山崎 辰洋, 内田 大輔, 堀口 繁, 堤 康一郎, 加藤 博也

    日本消化器病学会雑誌   120 ( 臨増総会 )   A292 - A292   2023.3

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  • EUS-HGSにおけるダブルガイドワイヤー法の有用性

    松三 明宏, 藤井 佑樹, 小幡 泰介, 佐藤 亮介, 織田 崇志, 菊池 達也, 宮本 和也, 森本 光作, 寺澤 裕之, 山崎 辰洋, 内田 大輔, 松本 和幸, 堀口 繁, 堤 康一郎, 加藤 博也, 大塚 基之

    日本消化器病学会雑誌   120 ( 臨増総会 )   A321 - A321   2023.3

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  • 胆嚢オルガノイドを用いた発癌モデルより同定したmiR-34a-5p補充による胆嚢癌治療の開発

    織田 崇志, 堤 康一郎, 小幡 泰介, 菊池 達也, 松三 明宏, 宮本 和也, 森本 光作, 寺澤 裕之, 藤井 佑樹, 山崎 辰洋, 赤穂 宗一郎, 内田 大輔, 松本 和幸, 堀口 繁, 加藤 博也, 大塚 基之

    日本消化器病学会雑誌   120 ( 臨増総会 )   A328 - A328   2023.3

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  • 後期高齢者におけるIPMNの治療移行割合についての検討

    宮本 和也, 松本 和幸, 小幡 泰介, 佐藤 亮介, 織田 崇志, 菊池 達也, 松三 明宏, 森本 光作, 寺澤 裕之, 藤井 佑樹, 山崎 辰洋, 内田 大輔, 堀口 繁, 堤 康一郎, 加藤 博也, 大塚 基之

    日本消化器病学会雑誌   120 ( 臨増総会 )   A378 - A378   2023.3

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  • 【胆膵EUSのトラブルシューティング】治療的EUS EUS-guided biliary drainage(EUS-BD) 処置後の腹痛

    加藤 博也, 内田 大輔, 松本 和幸, 堀口 繁, 堤 康一郎

    消化器内視鏡   34 ( 12 )   2011 - 2015   2022.12

  • Gastric linitis plastica with autoimmune pancreatitis diagnosed by an endoscopic ultrasonography-guided fine-needle biopsy: A case report. International journal

    Ryosuke Sato, Kazuyuki Matsumoto, Hiromitsu Kanzaki, Akihiro Matsumi, Kazuya Miyamoto, Kosaku Morimoto, Hiroyuki Terasawa, Yuki Fujii, Tatsuhiro Yamazaki, Daisuke Uchida, Koichiro Tsutsumi, Shigeru Horiguchi, Hironari Kato

    World journal of clinical cases   10 ( 31 )   11607 - 11616   2022.11

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    BACKGROUND: Gastric linitis plastica (GLP) is a subset of gastric cancer with a poor prognosis. It is difficult to obtain a definitive diagnosis by endoscopic mucosal biopsies, and the usefulness of an endoscopic ultrasonography-guided fine-needle biopsy (EUS-FNB) for GLP has been recently reported. Meanwhile, autoimmune diseases are occasionally known to coexist with malignant tumors as paraneoplastic syndrome. We herein report the usefulness of an EUS-FNB for detecting GLP and the possibility of paraneoplastic syndrome coexisting with GLP. CASE SUMMARY: An 81-year-old man was admitted to our hospital for a 1-mo history of epigastric pain that increased after eating. His laboratory data revealed high levels of serum carbohydrate antigen 19-9 and immunoglobulin-G4. Endoscopic examinations showed giant gastric folds and reddish mucosa; however, no epithelial changes were observed. The gastric lumen was not distensible by air inflation, suggesting GLP. Computed tomography showed the thickened gastric wall, the diffuse enlargement of the pancreas, and the peripancreatic rim, which suggested autoimmune pancreatitis (AIP) coexisting with GLP. Because the pathological findings of the endoscopic biopsy showed no malignancy, he underwent an EUS-FNB and was diagnosed with GLP. He received chemotherapy for unresectable gastric cancer due to peritoneal metastasis, after which both the gastric wall thickening and diffuse enlargement of the pancreas were improved. CONCLUSION: An EUS-FNB for GLP with a negative endoscopic biopsy is useful, and AIP may develop as a paraneoplastic syndrome.

    DOI: 10.12998/wjcc.v10.i31.11607

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  • ペムブロリズマブが奏功した高頻度マイクロサテライト不安定性を有する肝内胆管癌の1例

    角田 太助, 藤井 佑樹, 堀口 繁, 松三 明宏, 宮本 和也, 森本 光作, 寺澤 裕之, 山崎 辰洋, 内田 大輔, 松本 和幸, 堤 康一郎, 加藤 博也

    日本消化器病学会中国支部例会・日本消化器内視鏡学会中国支部例会プログラム・抄録集   118回・129回   90 - 90   2022.11

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  • アンメットメディカルニーズへの挑戦 当院における膵消化管神経内分泌腫瘍に対するペプチド受容体放射性核種療法(PRRT)導入後の現状

    藤井 佑樹, 堀口 繁, 内田 大輔, 松本 和幸, 加藤 博也

    日本消化器病学会中国支部例会・日本消化器内視鏡学会中国支部例会プログラム・抄録集   118回・129回   77 - 77   2022.11

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  • SpyGlass DSによるEHLと胆道鏡用バスケットが有用であった肝内結石の1例

    松三 明宏, 藤井 佑樹, 松本 和幸, 小幡 泰介, 織田 崇志, 菊池 達也, 宮本 和也, 森本 光作, 寺澤 裕之, 山崎 辰洋, 内田 大輔, 堀口 繁, 堤 康一郎, 加藤 博也

    日本消化器病学会中国支部例会・日本消化器内視鏡学会中国支部例会プログラム・抄録集   118回・129回   146 - 146   2022.11

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  • Linitis plastica型胃癌の診断に超音波内視鏡ガイド下針生検が有用であった1例

    佐藤 亮介, 寺澤 裕之, 松本 和幸, 松三 明宏, 宮本 和也, 森本 光作, 藤井 佑樹, 山崎 辰洋, 内田 大輔, 堤 康一郎, 堀口 繁, 加藤 博也

    日本消化器病学会中国支部例会・日本消化器内視鏡学会中国支部例会プログラム・抄録集   118回・129回   139 - 139   2022.11

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  • 生体肝移植後胆管狭窄に対する内視鏡治療

    山崎 辰洋, 松本 和幸, 加藤 博也, 松三 明宏, 宮本 和也, 寺澤 裕之, 藤井 佑樹, 内田 大輔, 堀口 繁, 堤 康一郎

    胆道   36 ( 3 )   344 - 344   2022.9

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  • Stent-in-stent techniqueにて抜去した胆管金属ステントの2例

    松三 明宏, 松本 和幸, 小幡 泰介, 織田 崇志, 菊池 達也, 宮本 和也, 森本 光作, 寺澤 裕之, 藤井 佑樹, 山崎 辰洋, 内田 大輔, 堀口 繁, 堤 康一郎, 加藤 博也

    胆道   36 ( 3 )   349 - 349   2022.9

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  • 『胆膵疾患と性差』分枝型IPMNの性差による画像的特徴と長期経過の検討

    宮本 和也, 松本 和幸, 松三 明宏, 森本 光作, 寺澤 裕之, 藤井 佑樹, 山崎 辰洋, 内田 大輔, 堀口 繁, 堤 康一郎, 加藤 博也

    日本高齢消化器病学会誌   25 ( 1 )   161 - 161   2022.7

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  • Plasma KRAS mutations predict the early recurrence after surgical resection of pancreatic cancer. International journal

    Soichiro Ako, Hironari Kato, Kazuhiro Nouso, Hideaki Kinugasa, Hiroyuki Terasawa, Hiroshi Matushita, Saimon Takada, Yosuke Saragai, Sho Mizukawa, Shinichiro Muro, Daisuke Uchida, Takeshi Tomoda, Kazuyuki Matsumoto, Shigeru Horiguchi, Daisuke Nobuoka, Ryuichi Yoshida, Yuzo Umeda, Takahito Yagi, Hiroyuki Okada

    Cancer biology & therapy   22 ( 10-12 )   564 - 570   2021.12

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    BACKGROUND: The technique to analyze circulating tumor DNA (ctDNA) in body fluid (so-called "liquid biopsy") is recently developed. AIMS: Our aim was to assess the utility of liquid biopsy for predicting progression of pancreatic ductal adenocarcinoma (PDAC) after surgical resection or chemotherapy. METHODS: A total of 72 patients with PDAC were retrospectively enrolled for this study, 33 treated surgically and 39 given chemotherapy, either FOLFIRINOX (oxaliplatin/irinotecan/fluorouracil/leucovorin) or gemcitabine plus nab-paclitaxel. Prior to treatment, patients were screened for the presence of KRAS mutations (G12D and G12V) in plasma using droplet digital polymerase chain reaction, and outcomes were compared. RESULTS: KRAS mutations were identified in plasma samples of 12 patients (36%) underwent surgical resection. Patients with plasma KRAS mutations had significantly shorter disease-free survival (DFS) and overall survival (p < .01 and p = .01, respectively). Of 10 clinical variables analyzed, plasma KRAS mutation was the factor predictive of DFS in multivariate analysis (RR = 3.58, 95% CI: 1.36-9.60; p = .01). Although 12 patients (31%) given chemotherapy tested positive for plasma KRAS mutations, there was no demonstrable relation between plasma KRAS mutations and progression-free survival (PFS) or overall survival (OS) (p = .35 and p = .68, respectively). CONCLUSIONS: In patients with PDAC, detection of KRAS mutations in plasma proved independently predictive of early recurrence after surgical resection but did not correlate with PFS following chemotherapy.

    DOI: 10.1080/15384047.2021.1980312

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  • Risk Factors for the Development of High-risk Stigmata in Branch-duct Intraductal Papillary Mucinous Neoplasms.

    Tatsuhiro Yamazaki, Takeshi Tomoda, Hironari Kato, Kazuya Miyamoto, Akihiro Matsumi, Eijiro Ueta, Yuki Fujii, Yosuke Saragai, Daisuke Uchida, Kazuyuki Matsumoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hiroyuki Okada

    Internal medicine (Tokyo, Japan)   60 ( 20 )   3205 - 3211   2021.10

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    Objective Strict follow-up is recommended for branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) to avoid missing the development of high-risk stigmata (HRS) at a premalignant stage. This study explored the risk factors associated with the development of HRS during follow-up. Methods We performed a retrospective analysis of 283 patients with BD-IPMN, treated at Okayama University Hospital in Japan between January 2009 and December 2016. Only patients with imaging studies indicative of classical features of BD-IPMN without HRS and followed for over one year were included in the study. We performed radiological follow-up every six months and collected patients' demographic data, cyst characteristics, and clinical outcomes and used univariate logistic regression models to determine the odds of developing HRS. Results Ten patients (3.5%) developed HRS after a median surveillance period of 55.8 months. The main pancreatic duct (MPD) size (5-9 mm) and cyst growth rate (>2.5 mm/year) were both suggested to be possible risk factors for the development of HRS [odds ratio, 14.2; 95% confidence interval (CI), 3.1-65.2, p=0.0006, and odds ratio, 6.1; 95% CI 1.5-25.5, p=0.014]. Regarding the number of worrisome features (WFs), the rate of HRS development was 2.0% (4/199) in cases with no WF, 1.6% (1/62) in cases with single WF and 22.7% (5/22) in cases with multiple WFs, respectively. The rate of HRS development was significantly higher in cases with multiple WFs than in the other cases (p<0.0001). Conclusion MPD dilation, rapid cyst growth, and multiple WFs were significant risk factors for the development of HRS. In the presence of such features, it is necessary to closely follow the development of HRS and avoid missing the best opportunity to perform surgical intervention.

    DOI: 10.2169/internalmedicine.7168-21

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  • Laminin-411 and -511 Modulate the Proliferation, Adhesion, and Morphology of Gastric Cancer Cells. International journal

    Masaya Iwamuro, Hidenori Shiraha, Atsushi Oyama, Daisuke Uchida, Shigeru Horiguchi, Hiroyuki Okada

    Cell biochemistry and biophysics   79 ( 2 )   407 - 418   2021.6

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    Laminins (Ln), a type of extracellular matrix glycoprotein, are key regulators of cellular behavior. Recent work revealed that in various tumor cell lines, laminin isoforms influence specific responses, such as cell anchorage, survival, proliferation, migration, organization, and specialization. The contribution of laminin isoforms to the function of gastric cancer cells, however, remain unclear. Here, we revealed that in gastric cancer, laminin isoforms Ln411, Ln421, Ln511, and Ln521 promote cellular proliferation; Ln511 and Ln521 increase cell cytoplasmic volume; Ln511 hampers invadopodia formation in some cells, Ln511 enables prompt adhesion of cells to plates, and Ln411 and Ln511 do not alter the gastric cancer stem cell markers CD44 and Lgr5. These results indicate that Ln411 and Ln511 dynamically modulate the proliferation, adhesion, and morphology of gastric cancer cells in different ways that are independent of stem cell properties. In particular, Ln511 showed a high affinity for gastric cancer cells. Our observations broaden the possible options for controlling cancer cell progression and metastasis by modulating laminin-integrin interactions.

    DOI: 10.1007/s12013-021-00972-3

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  • Efficacy of low dose rectal diclofenac for preventing post-endoscopic retrograde cholangiopancreatography pancreatitis: Propensity score-matched analysis. International journal

    Takeshi Tomoda, Hironari Kato, Kazuya Miyamoto, Akihiro Matsumi, Eijiro Ueta, Yuuki Fujii, Yousuke Saragai, Tatsuhiro Yamazaki, Daisuke Uchida, Kazuyuki Matsumoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hiroyuki Okada

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   33 ( 4 )   656 - 662   2021.5

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    BACKGROUND: Acute pancreatitis is a major adverse event of endoscopic retrograde cholangiopancreatography (ERCP). Rectal administration of non-steroidal anti-inflammatory drugs (NSAIDs) decreases the incidence of post-ERCP pancreatitis (PEP). However, the efficacy of low dose rectal NSAIDs for preventing PEP remains controversial. METHODS: We performed a retrospective study of 301 patients with native papilla and a body weight of <50 kg who underwent ERCP between September 2010 and October 2019. After July 2016, a 25 mg dose of rectal diclofenac was routinely administered within 15 min before ERCP (NSAIDs group, n = 72) and the control group (n = 229) consisted of patients undergoing ERCP before this date without treatment. We compared the incidence of PEP between the two groups using propensity score matching. RESULTS: A total of 66 pairs of patients in each group were selected. The patients and procedural-related factors were similar in both groups. In total, 15 patients (11.4%) developed PEP: 12.1% (8/66) in the NSAIDs group and 10.6% (7/66) in the control group (Odds ratio (OR) 1.2; 95% confidence interval (CI) 0.4-3.5; P = 0.78). There was no significant difference in incidence of other adverse events related to ERCP between the two groups. CONCLUSIONS: Prophylactic administration of a 25 mg dose of rectal diclofenac did not reduce the incidence of PEP in patients with a native papilla and a body weight of <50 kg in this study and a certain dose of rectal NSAIDs, such as a 100-mg dose, should be administered regardless of body weight to prevent PEP.

    DOI: 10.1111/den.13828

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  • Treatment outcomes, including risk factors of stone recurrence, for hepatolithiasis using balloon-assisted endoscopy in patients with hepaticojejunostomy (with video). International journal

    Yuki Ishihara, Kazuyuki Matsumoto, Hironari Kato, Koichiro Tsutsumi, Takeshi Tomoda, Akihiro Matsumi, Kazuya Miyamoto, Tatsuhiro Yamazaki, Yosuke Saragai, Yuki Fujii, Daisuke Uchida, Shigeru Horiguchi, Hiroyuki Okada

    Surgical endoscopy   35 ( 4 )   1895 - 1902   2021.4

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    BACKGROUND AND STUDY AIMS: Endoscopic treatment outcomes for hepatolithiasis in patients with altered anatomy are not well known. The aim of this study was to evaluate the treatment outcomes of hepatolithiasis in patients with hepaticojejunostomy (HJ) using short-type double-balloon endoscopy (sDBE) and to assess the risk factors for stone recurrence. PATIENTS AND METHODS: This was a retrospective cohort study that consisted of 73 patients with hepatolithiasis who underwent bowel reconstruction with HJ at an academic center. Stone removal was performed using sDBE. After balloon-occluded cholangiography using sDBE, peroral direct cholangioscopy (PDCS) using ultraslim endoscopy was performed to check for residual stones, depending on the bowel reconstruction method. Recurrence was defined as the development of cholangitis from stones. RESULTS: The success rate of reaching the HJ site was 92% (67/73), and the complete stone removal rate was 93% (62/67) with multiple sessions (mean number 1.5 ± 0.9). The occurrence rate of procedure-related adverse events was 6.8%. Among 58 patients evaluated for stone recurrence, 13 (22%) developed recurrence during a median follow-up period of 2.7 years (interquartile range: 1.5-4.8). Multivariate analyses determined that a stone diameter ≥ 8 mm [odds ratio (OR), 5.57; 95% confidence interval (CI), 1.39-37.2; p = 0.013] and performing PDCS (OR, 0.16; 95% CI, 0.0084-0.90; p = 0.036) were significant factors for stone recurrence. CONCLUSIONS: Endoscopic treatment using sDBE for hepatolithiasis was effective and safe. PDCS might reduce the rate of stone recurrence by detecting stones that are too small to confirm on fluoroscopic images.

    DOI: 10.1007/s00464-020-08139-6

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  • The efficacy of pancreatic juice cytology with liquid-based cytology for evaluating malignancy in patients with intraductal papillary mucinous neoplasm

    Kazuya Miyamoto, Kazuyuki Matsumoto, Hironari Kato, Ryuichi Yoshida, Yuzo Umeda, Hirohumi Inoue, Takehiro Tanaka, Akihiro Matsumi, Yosuke Saragai, Yuki Fujii, Tatsuhiro Yamazaki, Daisuke Uchida, Takeshi Tomoda, Shigeru Horiguchi, Takahito Yagi, Hiroyuki Okada

    BMC Gastroenterology   20 ( 1 )   2020.12

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    <title>Abstract</title>
    <sec>
    <title>Background</title>
    Pancreatic juice cytology (PJC) is a tool for diagnosing malignant intraductal papillary mucinous neoplasm (IPMN); however, the accuracy is insufficient using the conventional method. Liquid-based cytology (LBC) improves the cell recovery rate, and almost all cells can be evaluated. We evaluated the efficacy of PJC with LBC for malignant IPMN.


    </sec>
    <sec>
    <title>Methods</title>
    We retrospectively analyzed 90 patients with suspected malignant IPMN who underwent PJC before pancreatectomy. PJC with smear and LBC methods was conducted in 52 patients (between June 2003 to December 2011) and 38 patients (between January 2012 to December 2018). Based on the imaging studies, all of the patients were classified according to the international consensus guidelines for IPMN revised in 2017.


    </sec>
    <sec>
    <title>Results</title>
    Of the 90 patients, 43 (48%) had malignant IPMN (high-grade dysplasia or invasive carcinoma), and the remaining patients had non-malignant IPMN (intermediate- or low-grade dysplasia). LBC increased the accuracy of PJC for the diagnosis of malignant IPMN (smear method: 56% [29/52] vs. LBC method: 76% [29/38]; <italic>P</italic> = 0.044). In a multivariate analysis, LBC was a significant factor influencing the accurate diagnosis of PJC (odds ratio: 3.52; <italic>P</italic> = 0.021). Furthermore, LBC increased the accuracy of PJC for malignant IPMN in patients with worrisome features (smear method: 66% [19/29] vs. LBC method: 93% [14/15]; <italic>P</italic> = 0.043).


    </sec>
    <sec>
    <title>Conclusions</title>
    LBC increases the accuracy of PJC for diagnosing malignant IPMN compared with the conventional smear method.


    </sec>

    DOI: 10.1186/s12876-020-01465-y

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  • Effectiveness of Menghini-Type Needles for Endoscopic Ultrasound-Guided Fine-Needle Aspiration of Pancreatic Masses. International journal

    Sho Mizukawa, Hironari Kato, Kazuyuki Matsumoto, Shinichiro Muro, Yutaka Akimoto, Daisuke Uchida, Takeshi Tomoda, Naoki Yamamoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hirofumi Inoue, Noriyuki Tanaka, Hiroyuki Okada

    Digestive diseases and sciences   66 ( 9 )   3171 - 3178   2020.10

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    BACKGROUND: Cutting needles are thought to be effective as biopsy needles. A few types of cutting needles are available for endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), and the Menghini-type needle is an end-type cutting needle. AIMS: A prospective randomized controlled trial was conducted to compare the results of EUS-FNA using a Menghini-type needle (needle M) versus a conventional needle (needle S). METHODS: The main eligibility criteria were as follows: patients with a pancreatic mass referred for EUS-FNA, ≥ 20 years old, and a performance status < 4. The primary outcome was the sample quality. The secondary outcomes were factors associated with the sample quality, diagnostic accuracy, and adverse events. RESULTS: A total of 97 patients were enrolled in this study. The sample quality for total puncture with needle M (92.8%) was significantly higher than that with needle S (81.4%) (p = 0.0305). The tumor size (p = 0.033) and type of needle (p = 0.031) were significant factors associated with adequate tissue collection in univariate and multivariate analyses (odds ratio [OR] 2.71; 95% confidence interval [CI] 1.12-6.54; p = 0.027 for tumor size, and OR 2.93; 95% CI 1.23-8.21; p = 0.0153 for type of needle). The diagnostic accuracy of each needle was 88.7% (86/97) with needle M and 73.2% (71/97) with needle S. Adverse events occurred in 2 of the 97 patients (0.02%). CONCLUSION: A Menghini-type needle was able to obtain core tissue for histology more effectively than a conventional aspiration needle. TRIAL REGISTRATION NUMBERS: UMIN registration number of 000020668.

    DOI: 10.1007/s10620-020-06628-1

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  • 悪性遠位胆管閉塞に対するself expandable metallic stentを用いた胆管ドレナージの治療成績の検討

    宮本 和也, 加藤 博也, 松三 明宏, 藤井 佑樹, 皿谷 洋祐, 山崎 辰洋, 内田 大輔, 友田 健, 松本 和幸, 堀口 繁, 岡田 裕之

    日本消化器病学会雑誌   117 ( 臨増大会 )   A790 - A790   2020.10

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  • 悪性胆道狭窄に対するMetallic stent留置に伴う胆嚢炎の検討

    松三 明宏, 友田 健, 宮本 和也, 皿谷 洋祐, 藤井 佑樹, 山崎 辰洋, 内田 大輔, 松本 和幸, 堀口 繁, 加藤 博也, 岡田 裕之

    Gastroenterological Endoscopy   62 ( Suppl.2 )   2149 - 2149   2020.10

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  • Evaluation of Local Recurrence of Pancreatic Cancer by KRAS Mutation Analysis Using Washes from Endoscopic Ultrasound-Guided Fine-Needle Aspiration. International journal

    Kazuyuki Matsumoto, Hironari Kato, Kazuhiro Nouso, Soichiro Ako, Hideaki Kinugasa, Shigeru Horiguchi, Yosuke Saragai, Saimon Takada, Shuntaro Yabe, Shinichiro Muro, Daisuke Uchida, Takeshi Tomoda, Hiroyuki Okada

    Digestive diseases and sciences   65 ( 10 )   2907 - 2913   2020.10

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    BACKGROUND AND AIMS: The sensitivity of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for diagnosing the recurrence of pancreatic cancer is usually low because of difficulties in obtaining adequate samples for pathological examinations. We evaluated the efficacy of highly sensitive KRAS mutation analysis using EUS-FNA washes to detect cancer recurrence. METHODS: Nineteen consecutive patients with suspected pancreatic cancer recurrence after surgical resection were enrolled. All underwent EUS-FNA, and samples were obtained for pathological examination. After the first session, the inside of the FNA needle was washed with saline for DNA extraction. KRAS mutations were examined using digital droplet PCR (dPCR). RESULTS: The median needle puncture number used to obtain adequate pathological samples was two (range 1-6). In ten patients pathologically diagnosed with malignant pancreatic cancer, nine patients tested positive for a KRAS mutation. All patients who were not diagnosed with a malignant pancreatic cancer tested negative for a KRAS mutation. About half of surgically resected primary cancers (9/19) showed double KRAS mutations (G12V and G12D); however, all but one wash sample showed a single KRAS mutation, G12D. After including one patient who showed a malignant recurrence during follow-up, the sensitivities of a pathological diagnosis and KRAS analysis to detect recurrence were 90.9% and 81.8%, respectively. CONCLUSIONS: KRAS mutation analysis of needle wash samples using dPCR is a new methodology for the diagnosis of the local recurrence of pancreatic cancer. The diagnostic ability of dPCR with a one-time needle wash sample was comparable to a pathological diagnosis with multiple samplings.

    DOI: 10.1007/s10620-019-06006-6

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  • 急性膵炎後Pancreatic fluid collectionに対する内視鏡治療の現状

    山崎 辰洋, 加藤 博也, 宮本 和也, 松三 明宏, 上田 英次郎, 藤井 佑樹, 皿谷 洋祐, 内田 大輔, 友田 健, 松本 和幸, 岡田 裕之

    Gastroenterological Endoscopy   62 ( Suppl.2 )   2134 - 2134   2020.10

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  • 膵切除後膵液漏に対する内視鏡的膵管ドレナージ術の検討

    上田 英次郎, 加藤 博也, 内田 大輔, 松三 明宏, 宮本 和也, 藤井 佑樹, 皿谷 洋祐, 山崎 辰洋, 松本 和幸, 友田 健, 堤 康一郎, 堀口 繁, 岡田 裕之

    Gastroenterological Endoscopy   62 ( Suppl.2 )   2132 - 2132   2020.10

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  • 当院における肝門部領域良性胆道狭窄に対するInside stentの有用性の検討

    皿谷 洋祐, 加藤 博也, 上田 英次郎, 松三 明宏, 宮本 和也, 藤井 佑樹, 山崎 辰洋, 内田 大輔, 友田 健, 堀口 繁, 堤 康一郎, 岡田 裕之

    胆道   34 ( 3 )   582 - 582   2020.8

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  • Decreased Serum Antioxidant Marker is Predictive of Early Recurrence in the Same Segment after Radical Ablation for Hepatocellular Carcinoma.

    Taiko Muro, Shinichiro Nakamura, Akinobu Takaki, Hideki Onishi, Nozomu Wada, Tetsuya Yasunaka, Daisuke Uchida, Atsushi Oyama, Takuya Adachi, Hidenori Shiraha, Hiroyuki Okada

    Acta medica Okayama   74 ( 4 )   275 - 283   2020.8

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    Radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) is a promising method for controlling tumors, although it does not entirely eliminate recurrence. Oxidative stress is associated with the progression of hepatocarcinogenesis, while also acting as an anticancer response. The objective of the present study was to investigate the factors influencing post-RFA outcomes. We recruited 235 newly diagnosed HCC patients who received RFA for single tumors. The patients with recurrence were sub-grouped into early and segmental recurrence groups. The characteristics of the sub-grouped patients were evaluated, including by measuring oxidative stress marker reactive oxygen metabolites and antioxidant marker OXY-adsorbent tests. The factors associated with poor survival were a high Child-Pugh score and early recurrence within 2 years in the same segment. The patients who experienced recurrence within 2 years in the same segment showed a larger tumor diameter than did others. According to a multivariate analysis, the OXY values were also significantly low in these patients. In conclusion, maintaining the antioxidant reservoir function with a high OXY value might be necessary to prevent early recurrence within the RFA-treated segment.

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  • 当院における肝門部領域良性胆道狭窄に対するInside stentの有用性の検討

    皿谷 洋祐, 加藤 博也, 上田 英次郎, 松三 明宏, 宮本 和也, 藤井 佑樹, 山崎 辰洋, 内田 大輔, 友田 健, 堀口 繁, 堤 康一郎, 岡田 裕之

    胆道   34 ( 3 )   582 - 582   2020.8

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  • EUSガイド下エタノール注入療法を施行したインスリノーマの1例

    松本 和幸, 加藤 博也, 稲垣 兼一, 宮本 和也, 山崎 辰洋, 藤井 祐樹, 内田 大輔, 友田 健, 堀口 繁, 岡田 裕之

    膵臓   35 ( 3 )   A449 - A449   2020.7

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  • EUS画像に基づいたIPMN組織亜型予測診断

    藤井 佑樹, 松本 和幸, 加藤 博也, 上田 英次郎, 宮本 和也, 松三 明宏, 皿谷 洋祐, 山崎 辰洋, 内田 大輔, 友田 健, 堀口 繁, 堤 康一郎, 八木 孝仁, 花田 敬士, 岡田 裕之

    膵臓   35 ( 3 )   A288 - A288   2020.7

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  • 【消化器疾患とステント治療】良性膵管狭窄に対する内視鏡的ステント治療

    松本 和幸, 加藤 博也, 内田 大輔, 堤 康一郎, 堀口 繁, 松三 明宏, 宮本 和也, 藤井 祐樹, 山崎 辰洋, 皿谷 洋祐, 友田 健, 岡田 裕之

    消化器・肝臓内科   8 ( 1 )   50 - 56   2020.7

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  • IPMN国際診療ガイドライン2017の検証 分枝型IPMN経過観察症例におけるHRS出現のリスク因子

    山崎 辰洋, 友田 健, 加藤 博也, 宮本 和也, 松三 明宏, 皿谷 洋祐, 内田 大輔, 松本 和幸, 堀口 繁, 堤 康一朗, 岡田 裕之

    膵臓   35 ( 3 )   A202 - A202   2020.7

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  • The Long-Term Outcomes of Endoscopic Papillectomy and Management of Cases of Incomplete Resection: A Single-Center Study. Reviewed International journal

    Shinichiro Muro, Hironari Kato, Akihiro Matsumi, Yuki Ishihara, Yosuke Saragai, Shuntaro Yabe, Saimon Takata, Daisuke Uchida, Takeshi Tomoda, Kazuyuki Matsumoto, Shigeru Horiguchi, Hiroyuki Okada

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract   25 ( 5 )   1247 - 1252   2020.6

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    BACKGROUND: Endoscopic papillectomy is increasingly performed as an alternative to surgery for early ampullary tumors. AIM: This retrospective study aimed to evaluate the long-term results of endoscopic papillectomy, the management of cases with incomplete endoscopic resection, and the long-term recurrence rates. METHODS: All 46 patients who underwent endoscopic papillectomy for ampullary tumors between November 2003 and March 2018 were retrospectively evaluated. RESULTS: The final pathological diagnoses were adenoma (n = 44) and adenocarcinoma (n = 2). Histopathological evaluations after endoscopic papillectomy revealed that complete resection was achieved in 19 patients (19/46, 41.3%). Among the 27 patients with incomplete resection, the margin was histopathologically positive in 14 patients and difficult to evaluate in 13. Additional surgery was performed for 2 of the 14 patients with positive margins. Excluding 2 patients who received additional surgery, 7 of the 25 patients with incomplete resection had recurrence, and 18 had no recurrence during the follow-up period. Ten (77%) of the 13 patients in whom the margin was difficult to evaluate had no recurrence. CONCLUSION: Approximately 80% of the patients in whom the histopathological evaluation of the resected margin was difficult had no recurrence even after approximately 5 years of follow-up. Thus, careful observation may be considered for these patients.

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  • 超音波内視鏡検査時の十二指腸穿孔に対しOver-The-Scope Clip(OTSC)Systemによる創閉鎖が有効であった1例

    藤井 佑樹, 松本 和幸, 神崎 洋光, 松三 明宏, 宮本 和也, 皿谷 洋祐, 山崎 辰洋, 内田 大輔, 友田 健, 堀口 繁, 加藤 博也, 岡田 裕之

    日本消化器内視鏡学会中国支部例会   124回   55 - 55   2020.6

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  • 胆管内で断裂したガイドワイヤーに対してSpy Glass DSを用いて回収可能であった一例

    河原 聡一郎, 友田 健, 宮本 和也, 松三 明宏, 藤井 佑樹, 山崎 辰洋, 皿谷 洋祐, 内田 大輔, 松本 和幸, 堀口 繁, 加藤 博也, 岡田 裕之

    日本消化器内視鏡学会中国支部例会   124回   57 - 57   2020.6

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  • Serum REIC/Dickkopf-3 Protein Level Predicts Disease-Free Survival in Patients with Hepatocellular Carcinoma. Reviewed

    Atsushi Oyama, Daisuke Uchida, Hidenori Shiraha, Hiroaki Sawahara, Ryo Kato, Masaya Iwamuro, Shigeru Horiguchi, Hiroyuki Okada

    Acta medica Okayama   74 ( 3 )   237 - 243   2020.6

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    The physiological role of the reduced expression of immortalized cells (REIC)/Dickkopf-3 (Dkk-3) protein in patients with hepatocellular carcinoma (HCC) remains unclear. In this study, we evaluated the effect of the REIC/Dkk-3 protein on HCC cell proliferation and assessed the relationship between the serum REIC/Dkk-3 protein level and the prognosis in patients with HCC. We evaluated the REIC/Dkk-3 protein-induced anticancer effects on Huh7 and Hep3B cells (HCC cell lines) in the presence of peripheral blood mononuclear cells (PBMCs), and found that combination treatment with REIC/Dkk-3 protein and PBMCs reduced the proliferation of HCC cells (Hep3B: 82.0%±16.3%; Huh7: 72.6%±9.1%). We also studied 194 HCC patients who underwent primary liver resection or primary radiofrequency ablation from 2008 to 2017. Serum REIC/Dkk-3 protein levels were measured by an enzyme-linked immunosorbent assay and compared to the prognostic data. The 3-year disease-free survival of the REIC/Dkk-3 high group was significantly higher than that in the REIC/Dkk-3 low group. In conclusion, this is the first study investigating the relationship between HCC patient survival and serum REIC/Dkk-3 protein levels in a large population. Based on the results, the serum REIC/Dkk-3 protein level should be considered a new prognostic marker for patients with HCC.

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  • 中国地方の消化器内視鏡学のState of the art 術後再建腸管例に対する経空腸的EUS-FNAの検討

    山崎 辰洋, 友田 健, 宮本 和也, 松三 明宏, 藤井 佑樹, 皿谷 洋祐, 内田 大輔, 松本 和幸, 堀口 繁, 堤 康一朗, 加藤 博也, 岡田 裕之

    日本消化器内視鏡学会中国支部例会   124回   28 - 28   2020.6

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  • Oxidative Stress Management in Chronic Liver Diseases and Hepatocellular Carcinoma. Reviewed International journal

    Daisuke Uchida, Akinobu Takaki, Atsushi Oyama, Takuya Adachi, Nozomu Wada, Hideki Onishi, Hiroyuki Okada

    Nutrients   12 ( 6 )   2020.5

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    Chronic viral hepatitis B and C and non-alcoholic fatty liver disease (NAFLD) have been widely acknowledged to be the leading causes of liver cirrhosis and hepatocellular carcinoma. As anti-viral treatment progresses, the impact of NAFLD is increasing. NAFLD can coexist with chronic viral hepatitis and exacerbate its progression. Oxidative stress has been recognized as a chronic liver disease progression-related and cancer-initiating stress response. However, there are still many unresolved issues concerning oxidative stress, such as the correlation between the natural history of the disease and promising treatment protocols. Recent findings indicate that oxidative stress is also an anti-cancer response that is necessary to kill cancer cells. Oxidative stress might therefore be a cancer-initiating response that should be down regulated in the pre-cancerous stage in patients with risk factors for cancer, while it is an anti-cancer cell response that should not be down regulated in the post-cancerous stage, especially in patients using anti-cancer agents. Antioxidant nutrients should be administered carefully according to the patients' disease status. In this review, we will highlight these paradoxical effects of oxidative stress in chronic liver diseases, pre- and post-carcinogenesis.

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  • 増大傾向を認める脾原発炎症性偽腫瘍の1例

    姫井 人美, 友田 健, 宮本 和也, 松三 明宏, 皿谷 洋祐, 藤井 佑樹, 山崎 辰洋, 内田 大輔, 松本 和幸, 堀口 繁, 堤 康一郎, 加藤 博也, 岡田 裕之

    日本消化器病学会中国支部例会プログラム・抄録集   113回   110 - 110   2020.5

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  • 【肝膵内視鏡治療におけるトラブルシューティング】EUS下治療における偶発症予防とトラブルシューティング WONに対する内視鏡的ネクロセクトミー こんなときどうする?

    加藤 博也, 内田 大輔, 友田 健, 松本 和幸, 堀口 繁, 堤 康一郎, 岡田 裕之

    消化器内視鏡   32 ( 3 )   431 - 436   2020.3

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  • Correction to: Outcomes of endoscopic treatment for malignant biliary obstruction in patients with surgically altered anatomy: analysis of risk factors for clinical failure. Reviewed International journal

    Takeshi Tomoda, Hironari Kato, Kazuya Miyamoto, Akihiro Matsumi, Eijiro Ueta, Yuuki Fujii, Yousuke Saragai, Tatsuhiro Yamazaki, Daisuke Uchida, Kazuyuki Matsumoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hiroyuki Okada

    Surgical endoscopy   35 ( 1 )   239 - 240   2020.2

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    There are several places where the P-value and Odds ratio in Table 3 are incorrect: these are shown in the corrected Table 3 below.

    DOI: 10.1007/s00464-020-07399-6

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  • Promising Gene Therapy Using an Adenovirus Vector Carrying REIC/Dkk-3 Gene for the Treatment of Biliary Cancer. Reviewed International journal

    Emi Tanaka, Daisuke Uchida, Hidenori Shiraha, Hironari Kato, Atsushi Ohyama, Masaya Iwamuro, Masami Watanabe, Hiromi Kumon, Hiroyuki Okada

    Current gene therapy   20 ( 1 )   64 - 70   2020

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    BACKGROUND: We previously demonstrated that the reduced expression in immortalized cells (REIC)/dikkopf-3 (Dkk-3) gene was downregulated in various malignant tumors, and that an adenovirus vector carrying the REIC/Dkk-3 gene, termed Ad-REIC induced cancer-selective apoptosis in pancreatic cancer and hepatocellular carcinoma. OBJECTIVE: In this study, we examined the therapeutic effects of Ad-REIC in biliary cancer using a second- generation Ad-REIC (Ad-SGE-REIC). METHODS: Human biliary cancer cell lines (G-415, TFK-1) were used in this study. The cell viability and apoptotic effect of Ad-SGE-REIC were assessed in vitro using an MTT assay and Hoechst staining. The anti-tumor effect in vivo was assessed in a mouse xenograft model. We also assessed the therapeutic effects of Ad-SGE-REIC therapy with cisplatin. Cell signaling was assessed by Western blotting. RESULTS: Ad-SGE-REIC reduced cell viability, and induced apoptosis in biliary cancer cell lines via the activation of the c-Jun N-terminal kinase pathway. Ad-SGE-REIC also inhibited tumor growth in a mouse xenograft model. This effect was further enhanced in combination with cisplatin. CONCLUSION: Ad-SGE-REIC induced apoptosis and inhibited tumor growth in biliary cancer cells. REIC/Dkk-3 gene therapy using Ad-SGE-REIC is an attractive therapeutic tool for biliary cancer.

    DOI: 10.2174/1566523220666200309125709

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  • Single-session esophagogastroduodenoscopy and endoscopic ultrasound using a forward-viewing radial scan ultrasonic endoscope. Reviewed International journal

    Uchida D, Kato H, Matsumoto K, Ishihara Y, Matsumi A, Saragai Y, Takada S, Yabe S, Muro S, Tomoda T, Horiguchi S, Okada H

    BMC gastroenterology   19 ( 1 )   220 - 220   2019.12

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    BACKGROUND: Endoscopic ultrasound is useful for obtaining high-resolution images of pancreaticobiliary diseases, but is not readily available for physical checkups. In this study, we evaluated the safety and efficacy of single-session esophagogastroduodenoscopy and endoscopic ultrasound in the detection of upper-gastrointestinal and pancreaticobiliary diseases using a forward-viewing radial scan ultrasonic endoscope. METHODS: A total of 148 patients who were scheduled for upper-gastrointestinal screening using an endoscope were prospectively included. All patients were examined by EUS in combination with EGD using a forward-viewing radial scan ultrasonic endoscope. The primary endpoint was the safety of the procedures. The secondary endpoints were the prevalence of diseases, the basal imaging capability of EUS, the procedure time, total dose of propofol, and the correlation between background factors and the prevalence of pancreatic disease. The imaging capability at each region was scored as 0 (invisible) to 2 (sufficient visualization to evaluate the organs). RESULTS: Intraoperative hypotension occurred as an adverse event of intravenous anesthesia in one patient. There were 82 pancreaticobiliary findings and 165 upper-gastrointestinal findings (malignancy not included). Follicular lymphoma of the intra-abdominal lymph nodes was detected in one patient. The mean imaging scores of each section were 1.95 (pancreatic head and papilla), 2.0 (pancreatic body), 1.99 (pancreatic tail), and 1.89 (common bile duct and gallbladder). Age, history of diabetes mellitus, and smoking history were significantly associated with the prevalence of pancreatic diseases. CONCLUSION: The simultaneous performance of EGD and EUS using a new ultrasonic endoscope is tolerable and safe for upper-gastrointestinal and pancreaticobiliary screening.

    DOI: 10.1186/s12876-019-1141-7

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  • Utility of Endoscopic Ultrasound-Guided Fine Needle Aspiration in the Diagnosis of Local Recurrence of Pancreaticobiliary Cancer after Surgical Resection. Reviewed International journal

    Matsumoto K, Kato H, Horiguchi S, Tomoda T, Matsumi A, Ishihara Y, Saragai Y, Takada S, Muro S, Uchida D, Okada H

    Gut and liver   14 ( 5 )   652 - 658   2019.12

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    Background/Aims: Endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA; EUS-FNA) allows for diagnostic tissue specimens from various regions to be analyzed. However, diagnosing recurrent pancreaticobiliary cancer after surgery is sometimes difficult. We evaluated the efficacy of EUS-FNA in the diagnosis of local recurrence of pancreaticobiliary cancer and analyzed the factors associated with falsenegative results. Methods: Fifty-one consecutive patients who underwent EUS-FNA due to suspected recurrence of pancreaticobiliary cancer after surgery in an academic center were retrospectively analyzed. The criteria for EUS-FNA were a resected margin or remnant pancreas mass, round swollen lymph node (≥10 mm in diameter), and soft-tissue enhancement around a major artery. Patients with suspected liver metastasis or malignant ascites were excluded. Results: Thirty-nine of the 51 patients had pancreatic cancer; the remaining 12 had biliary cancer. The target sites for EUS-FNA were the soft tissue around a major artery (n=22, 43%), the resected margin or remnant pancreas (n=12, 24%), and the lymph nodes (n=17, 33%). The median size of the suspected recurrent lesions was 15 mm (range, 8 to 40 mm). The overall sensitivity, specificity and accuracy of EUS-FNA for the diagnosis of recurrence was 84% (32/38), 100% (13/13), and 88% (45/51), respectively. FNA of the soft tissue around major arteries (odds ratio, 8.23; 95% confidence interval, 1.2 to 166.7; p=0.033) was significantly associated with a falsenegative diagnosis in the multivariate analysis. Conclusions: EUS-FNA is useful for diagnosing recurrent cancer, even after pancreaticobiliary surgery. The diagnoses of recurrence at soft-tissue sites should be interpreted with caution.

    DOI: 10.5009/gnl19200

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  • A Phase I/Ib trial of Ad-REIC in liver cancer: study protocol. Reviewed International journal

    Oyama A, Shiraha H, Uchida D, Iwamuro M, Kato H, Takaki A, Ikeda F, Onishi H, Yasunaka T, Takeuchi Y, Wada N, Iwasaki Y, Sakata M, Okada H, Kumon H

    Future oncology (London, England)   15 ( 31 )   3547 - 3554   2019.11

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    This study will assess the safety and efficacy of the administration of adenoviral vector expressing the human-reduced expression in immortalized cells (Ad-REIC) to a liver tumor in patients with hepatocellular carcinoma (HCC) or liver metastasis of pancreatic cancer. A Phase I clinical study of Ad-REIC administration to a liver tumor in a patient with HCC or liver metastasis of pancreatic cancer will be conducted. The study is a single-arm, prospective, nonrandomized, noncomparative, open-label, single-center trial performed in Okayama University Hospital, Okayama, Japan. Ad-REIC will be injected into the liver tumor under ultrasound guidance. Ad-REIC administration will be repeated a total of three-times every 2 weeks. The primary end point is the dose-limiting toxicity and incidence of adverse events. The secondary end points are the objective response rate and disease control rate. This study aims to expand the indication of Ad-REIC by assessing its safety and efficacy in patients with HCC or liver metastasis of pancreatic cancer.

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  • 胃全摘後の再建腸管を有する十二指腸乳頭部腺腫に対してUnderwater endoscopic papillectomyを施行した1例

    山崎 辰洋, 内田 大輔, 山崎 泰史, 宮本 和也, 松三 明宏, 藤井 佑樹, 皿谷 洋祐, 友田 健, 松本 和幸, 堀口 繁, 加藤 博也, 岡田 裕之

    日本消化器病学会中国支部例会プログラム・抄録集   112回   138 - 138   2019.11

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  • 【結石除去を極める】胆石 術後再建腸管症例における結石除去(BE-ERCP) Roux-en-Y再建症例(乳頭あり症例) Reviewed

    加藤 博也, 堤 康一郎, 内田 大輔, 友田 健, 松本 和幸, 堀口 繁, 岡田 裕之

    消化器内視鏡   31 ( 11 )   1648 - 1653   2019.11

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  • 再発性急性膵炎を契機に診断された主膵管型IPMNの1例

    松枝 真由, 内田 大輔, 上田 英次郎, 松三 明宏, 宮本 和也, 皿谷 洋祐, 山崎 辰洋, 藤井 佑樹, 友田 健, 松本 和幸, 堀口 繁, 堤 康一郎, 加藤 博也, 岡田 裕之

    日本消化器病学会中国支部例会プログラム・抄録集   112回   107 - 107   2019.11

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  • 内視鏡的乳頭切除術後膵管狭窄に対してEUSランデブー法を用いて膵管ステント留置を行った一例

    小川 泰司, 友田 健, 加藤 博也, 宮本 和也, 松三 明宏, 上田 英次郎, 藤井 祐樹, 皿谷 洋祐, 山崎 辰洋, 内田 大輔, 松本 和幸, 堀口 繁, 堤 康一郎, 岡田 裕之

    日本消化器病学会中国支部例会プログラム・抄録集   112回   137 - 137   2019.11

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  • Contrast-enhanced harmonic endoscopic ultrasound using time-intensity curve analysis predicts pathological grade of pancreatic neuroendocrine neoplasm. Reviewed

    Takada S, Kato H, Saragai Y, Muro S, Uchida D, Tomoda T, Matsumoto K, Horiguchi S, Tanaka N, Okada H

    Journal of medical ultrasonics (2001)   46 ( 4 )   449 - 458   2019.10

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    PURPOSE: Histological grading is important for the treatment algorithm in pancreatic neuroendocrine neoplasms (PNEN). The present study examined the efficacy of contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) and time-intensity curve (TIC) analysis of PNEN diagnosis and grading. METHODS: TIC analysis was performed in 30 patients using data obtained from CH-EUS, and a histopathological diagnosis was made via EUS-guided fine-needle aspiration or surgical resection. The TIC parameters were analyzed by dividing them into G1/G2 and G3/NEC groups. Then, patients were classified into non-aggressive and aggressive groups and evaluated. RESULTS: Twenty-six patients were classified as G1/G2, and four as G3/NEC. From the TIC analysis, five parameters were obtained (I: echo intensity change, II: time for peak enhancement, III: speed of contrast, IV: decrease rate for enhancement, and V: enhancement ratio for node/pancreatic parenchyma). Three of these parameters (I, IV, and V) showed high diagnostic performance. Using the cutoff value obtained from the receiver-operating characteristic (ROC) analysis, the correct diagnostic rates of parameters I, IV, and V were 96.7%, 100%, and 100%, respectively, between G1/G2 and G3/NEC. A total of 21 patients were classified into the non-aggressive group, and nine into the aggressive group. Using the cutoff value obtained from the ROC analysis, the accurate diagnostic rates of I, IV, and V were 86.7%, 86.7%, and 88.5%, respectively, between the non-aggressive and aggressive groups. CONCLUSION: CH-EUS and TIC analysis showed high diagnostic accuracy for grade diagnosis of PNEN. Quantitative perfusion analysis is useful to predict PNEN grade diagnosis preoperatively.

    DOI: 10.1007/s10396-019-00967-x

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  • プラスティックステントによる悪性遠位胆管狭窄の術前ドレナージの検討

    高田 斎文, 吉田 龍一, 安井 和也, 加藤 博也, 松三 明宏, 石原 祐基, 皿谷 洋祐, 室 信一郎, 内田 大輔, 友田 健, 堀口 繁, 八木 孝仁, 岡田 裕之

    Gastroenterological Endoscopy   61 ( Suppl.2 )   2191 - 2191   2019.10

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  • DPC公開データからみる日本の胆管結石、胆管炎診療の現状 内科的治療を行った症例での検討

    山崎 辰洋, 加藤 博也, 松三 明宏, 石原 裕基, 皿谷 洋祐, 室 信一郎, 内田 大輔, 友田 健, 松本 和幸, 堀口 繁, 岡田 裕之

    胆道   33 ( 3 )   529 - 529   2019.10

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  • 当院における胆道病変に対するEUS-FNAの現状

    皿谷 洋祐, 松本 和幸, 加藤 博也, 松三 明宏, 宮本 和也, 藤井 佑樹, 山崎 辰洋, 内田 大輔, 友田 健, 堀口 繁, 堤 康一郎, 岡田 裕之

    胆道   33 ( 3 )   525 - 525   2019.10

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  • 膵EUS-FNAの精度向上を目指して 胆膵領域の実地臨床におけるEUS-FNAの現状と問題点 ゲノム医療時代を迎えて

    堀口 繁, 加藤 博也, 堤 康一郎, 友田 健, 松本 和幸, 内田 大輔, 山崎 辰洋, 皿谷 洋祐, 宮本 和也, 松三 明宏, 上田 英次郎, 岡田 裕之

    日本臨床細胞学会雑誌   58 ( Suppl.2 )   561 - 561   2019.10

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  • Potential Factors Affecting Results of Short-Type Double-Balloon Endoscope-Assisted Endoscopic Retrograde Cholangiopancreatography. Reviewed International journal

    Daisuke Uchida, Koichiro Tsutsumi, Hironari Kato, Akihiro Matsumi, Yosuke Saragai, Takeshi Tomoda, Kazuyuki Matsumoto, Shigeru Horiguchi, Hiroyuki Okada

    Digestive diseases and sciences   65 ( 5 )   1460 - 1470   2019.9

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    BACKGROUND: Short-type double-balloon endoscope (DBE)-assisted endoscopic retrograde cholangiopancreatography (ERCP) has been developed as an alternative approach for cases with a surgically altered gastrointestinal anatomy. However, this technique is sometimes technically challenging and carries a risk of severe adverse events. AIMS: To evaluate the factors affecting the technical success rate and adverse events of DBE-ERCP. METHODS: A total of 319 patients (805 procedures) with a surgically altered gastrointestinal anatomy underwent short DBE-ERCP. The factors affecting the technical success rate and adverse events, and the learning curve of the trainees were retrospectively evaluated. RESULTS: The technical success rate of all procedures was 90.7%. Adverse events occurred in 44 (5.5%) procedures. A multivariate analysis indicated that Roux-en-Y reconstruction and first-time short DBE-ERCP were factors affecting the technical failure and adverse event rates, while the modified Child method after subtotal stomach-preserving pancreaticoduodenectomy reconstruction was a non-risk factor for adverse events. The trainee caseload did not affect the technical success or adverse event rates significantly; however, trainees tended to perform cases involving the modified Child method after subtotal stomach-preserving pancreaticoduodenectomy reconstruction. The success rate of scope insertion increased according to experience; however, the overall success rate did not differ to a statistically significant extent. CONCLUSION: Short DBE-ERCP was useful and safe for managing cases with a surgically altered anatomy; however, trainees should concentrate on accumulating experience with easy cases, such as those with the modified Child method after subtotal stomach-preserving pancreaticoduodenectomy reconstruction or a history of DBE-ERCP.

    DOI: 10.1007/s10620-019-05857-3

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  • Successful removal of impacted large bile duct stones using electrohydraulic lithotripsy with an ultraslim endoscope after Billroth II gastrectomy. Reviewed International journal

    Matsumoto K, Kato H, Horiguchi S, Uchida D, Tomoda T, Muro S, Okada H

    Endoscopy   51 ( 9 )   E265 - E266   2019.9

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    DOI: 10.1055/a-0896-2498

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  • Underwater endoscopic papillectomy using double-balloon endoscopy. Reviewed International journal

    Yamazaki T, Uchida D, Yamasaki Y, Tomoda T, Matsumoto K, Kato H, Okada H

    Endoscopy   52 ( 2 )   E55-E56   2019.9

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    DOI: 10.1055/a-0992-9084

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  • Acute pancreatitis associated with massive bleeding due to a duodenal ulcer. Reviewed

    Uchida D, Kawai Y, Kato H, Okada H

    Clinical journal of gastroenterology   12 ( 4 )   301 - 306   2019.8

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    A 74-year-old man presented to the emergency department with acute abdominal pain in addition to anemia and melena, which were suspected to be due to gastrointestinal bleeding. Computed tomography (CT) revealed a blood-filled duodenum and acute pancreatitis. We prioritized treatments for pancreatitis, as the vital signs were stable, and temporary hemostasis was achieved. Two days later, esophagogastroduodenoscopy revealed a duodenal ulcer with an exposed vessel, and endoscopic hemostasis was performed. We urge clinicians to consider the possibility of pancreatitis associated with massive bleeding due to a duodenal ulcer.

    DOI: 10.1007/s12328-019-00942-6

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  • A "Back Light System" for Identification of Sites for Endoscopic Ultrasound-Guided Fine-Needle Aspiration in Solid Pancreatic Masses: A Prospective, Randomized Study with a Crossover Design. Reviewed International journal

    Ryo Harada, Hironari Kato, Soichiro Fushimi, Hirofumi Inoue, Daisuke Uchida, Yutaka Akimoto, Takeshi Tomoda, Kazuyuki Matsumoto, Yasuhiro Noma, Naoki Yamamoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hiroyuki Okada

    Clinical endoscopy   52 ( 4 )   334 - 339   2019.7

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    BACKGROUND/AIMS: We applied a back light system (BLS) with a magnifying glass to improve the ability to assess the adequacy of specimen sampling using endosonography. We conducted this study to evaluate the efficacy of the BLS in sampling of specimens by endoscopic ultrasound-guided fine needle aspiration of solid pancreatic masses. METHODS: This was a prospective, randomized, crossover, single-center clinical trial. An endosonographer evaluated adequacy on gross visual inspection and identified whitish specimen sampling sites with and without the BLS according to a randomization sequence in the first and second passes with a 25-G needle. On cytological evaluation, the presence of well-defined pancreatic ductal epithelium was evaluated by a cytopathologist who was blinded to any clinical information. RESULTS: A total of 80 consecutive patients were eligible during the study period. Adequacy was observed for 52 specimens (65%) with the BLS and 54 (68%) without the BLS (p=0.88). In assessment of specimen adequacy on gross examination, only fair agreement was observed both with and without BLS (kappa score 0.40 and 0.29, respectively). CONCLUSION: The BLS did not influence the ability to identify specimen sampling sites or reliable assessment of specimen site adequacy using gross visual inspection.

    DOI: 10.5946/ce.2019.004

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  • Comparison Between Endoscopic Biliary Stenting Combined with Balloon Dilation and Balloon Dilation Alone for the Treatment of Benign Hepaticojejunostomy Anastomotic Stricture. Reviewed International journal

    Takeshi Tomoda, Hironari Kato, Kazuya Miyamoto, Yousuke Saragai, Sho Mizukawa, Shuntaro Yabe, Saimon Takata, Shinichiro Muro, Daisuke Uchida, Kazuyuki Matsumoto, Shigeru Horiguchi, Koichiro Tsutsumi, Ken Hirao, Tsuneyoshi Ogawa, Hiroyuki Okada

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract   24 ( 6 )   1352 - 1358   2019.6

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    BACKGROUND: Hepaticojejunostomy anastomotic stricture (HJAS) is an important complication of biliary reconstructive surgery but has no standard treatment. We aimed to evaluate the outcomes of endoscopic treatment for benign HJAS and identify the risk factors for its recurrence. METHODS: This study retrospectively analyzed 176 patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) for HJAS between April 2008 and March 2016. The outcome of endoscopic biliary stenting combined with balloon dilation (EBS group) and balloon dilation alone (balloon group) was evaluated. RESULTS: The scope was successfully inserted into the HJ site in 93.8% patients (165/176), and 139 patients underwent endoscopic treatment after HJAS was confirmed. Successful biliary drainage was achieved in 137 patients by using ERCP and rendezvous procedures. Among these, 103 patients were included in balloon group and 34 patients were in EBS group. HJAS was resolved in 132 patients; five died from recurrence of primary disease. The 1 (3)-year bile duct patency rates in the balloon and EBS groups were 62.5% (46.6%) and 89.4% (84.7%), respectively (p = 0.015). Univariate analysis showed that balloon dilation (p = 0.009) and early HJAS formation (time from surgery to ERCP < 1 year) (p = 0.02) were risk factors for HJAS recurrence. In the multivariate analysis, balloon dilatation was identified as independent risk factors for HJAS recurrence. CONCLUSIONS: Balloon dilation without stent deployment and early HJAS formation are risk factors for HJAS recurrence after endoscopic treatment. Stent deployment might be recommended for definite resolution of HJAS.

    DOI: 10.1007/s11605-019-04297-8

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  • 切除不能局所進行膵癌:化学療法と化学放射線療法 当院における局所進行膵癌患者に対する化学放射線療法と化学療法の治療成績の検討

    皿谷 洋祐, 堀口 繁, 加藤 博也, 松三 明宏, 石原 裕基, 高田 斎文, 室 信一郎, 内田 大輔, 友田 健, 松本 和幸, 岡田 裕之

    膵臓   34 ( 3 )   A74 - A74   2019.6

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  • 膵頭部領域疾患の術前における閉塞性黄疸の至適マネージメント プラスティックステントによる膵頭部領域癌の術前胆管ドレナージの検討

    高田 斎文, 加藤 博也, 岡田 裕之, 石原 祐基, 松三 明宏, 皿谷 洋祐, 室 信一郎, 内田 大輔, 友田 健, 松本 和幸, 堀口 繁

    膵臓   34 ( 3 )   A91 - A91   2019.6

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  • Diagnostic Ability of Convex-Arrayed Endoscopic Ultrasonography for Major Vascular Invasion in Pancreatic Cancer. Reviewed International journal

    Fujii Y, Matsumoto K, Kato H, Saragai Y, Takada S, Mizukawa S, Muro S, Uchida D, Tomoda T, Horiguchi S, Tanaka N, Okada H

    Clinical endoscopy   52 ( 5 )   479 - 485   2019.5

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    BACKGROUND/AIMS: This study aimed to examine the diagnostic ability of endoscopic ultrasonography (EUS) for major vascular invasion in pancreatic cancer and to evaluate the relationship between EUS findings and pathological distance. METHODS: In total, 57 consecutive patients who underwent EUS for pancreatic cancer before surgery were retrospectively reviewed. EUS image findings were divided into four types according to the relationship between the tumor and major vessel (types 1 and 2: invasion, types 3 and 4: non-invasion). We also compared the EUS findings and pathologically measured distances between the tumors and evaluated vessels. RESULTS: The sensitivity, specificity, and accuracy of EUS diagnosis for vascular invasion were 89%, 92%, and 91%, respectively, in the veins and 83%, 94%, and 93%, respectively, in the arteries. The pathologically evaluated distances of cases with type 2 EUS findings were significantly shorter than those of cases with type 3 EUS findings in both the major veins (median [interquartile range], 96 [0-742] µm vs. 2,833 [1,076-5,694] µm, p=0.012) and arteries (623 [0-854] µm vs. 3,097 [1,396-6,000] µm, p=0.0061). All cases with a distance of ≥1,000 µm between the tumors and main vessels were correctly diagnosed. CONCLUSION: Tumors at a distance ≥1,000 µm from the main vessels were correctly diagnosed by EUS.

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  • 十二指腸乳頭部腫瘍の内視鏡切除術の現況と非完全切除例の取り扱いに関する検討

    室 信一郎, 加藤 博也, 岡田 裕之, 松三 明宏, 石原 裕基, 皿谷 洋祐, 矢部 俊太郎, 高田 斎文, 内田 大輔, 友田 健, 松本 和幸, 堀口 繁

    Gastroenterological Endoscopy   61 ( Suppl.1 )   923 - 923   2019.5

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  • 肝胆膵癌治療のup-to-date 当院における切除不能膵癌に対するFOLFIRINOX、GEM+nab-PTX併用についての検討

    皿谷 洋祐, 堀口 繁, 加藤 博也, 松三 明宏, 石原 裕基, 高田 斎文, 室 信一郎, 内田 大輔, 友田 健, 松本 和幸, 岡田 裕之

    日本消化器病学会中国支部例会プログラム・抄録集   111回   60 - 60   2019.5

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  • 標準治療無効後に膵癌薬物療法を行い、抗腫瘍効果を示した切除不能p-NET(G2)の1例

    山崎 辰洋, 室 信一郎, 加藤 博也, 松三 明宏, 石原 裕基, 皿谷 洋祐, 高田 斎文, 内田 大輔, 友田 健, 松本 和幸, 堀口 繁, 岡田 裕之

    日本消化器病学会中国支部例会プログラム・抄録集   111回   90 - 90   2019.5

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  • 術後胆管空腸吻合部良性狭窄に対するバルーン拡張単独治療の成績及び再狭窄関連因子に関する検討

    松三 明宏, 友田 健, 岡田 裕之, 加藤 博也, 石原 裕基, 皿谷 洋祐, 矢部 俊太郎, 高田 斎文, 室 信一郎, 内田 大輔, 松本 和幸, 堀口 繁

    Gastroenterological Endoscopy   61 ( Suppl.1 )   882 - 882   2019.5

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  • Biliary cannulation technique with ultraslim endoscope for a patient with Billroth II gastrectomy. Reviewed International journal

    Saragai Y, Uchida D, Kato H, Tomoda T, Matsumoto K, Horiguchi S, Okada H

    Endoscopy   51 ( 2 )   E38 - E39   2019.2

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    DOI: 10.1055/a-0800-8178

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  • Paradoxical Roles of Oxidative Stress Response in the Digestive System before and after Carcinogenesis. Reviewed International journal

    Takaki A, Kawano S, Uchida D, Takahara M, Hiraoka S, Okada H

    Cancers   11 ( 2 )   2019.2

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    Oxidative stress is recognized as a cancer-initiating stress response in the digestive system. It is produced through mitochondrial respiration and induces DNA damage, resulting in cancer cell transformation. However, recent findings indicate that oxidative stress is also a necessary anticancer response for destroying cancer cells. The oxidative stress response has also been reported to be an important step in increasing the anticancer response of newly developed molecular targeted agents. Oxidative stress might therefore be a cancer-initiating response that should be downregulated in the precancerous stage in patients at risk of cancer but an anticancer cell response that should not be downregulated in the postcancerous stage when cancer cells are still present. Many commercial antioxidant agents are marketed as "cancer-eliminating agents" or as products to improve one's health, so cancer patients often take these antioxidant agents. However, care should be taken to avoid harming the anticancerous oxidative stress response. In this review, we will highlight the paradoxical effects of oxidative stress and antioxidant agents in the digestive system before and after carcinogenesis.

    DOI: 10.3390/cancers11020213

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  • 当科における膵癌と血栓症についての検討

    堀口 繁, 加藤 博也, 友田 健, 松本 和幸, 内田 大輔, 室 信一郎, 高田 斎文, 皿谷 洋祐, 岡田 裕之

    日本内科学会雑誌   108 ( Suppl. )   172 - 172   2019.2

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  • [Metachronous intraductal papillary mucinous carcinoma five years after cholecystectomy for gallbladder cancer in a patient with pancreaticobiliary maljunction]. Reviewed

    Ikeda A, Matsumoto K, Kato H, Tanaka N, Ako S, Muro S, Uchida D, Tomoda T, Horiguchi S, Okada H

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   116 ( 3 )   241 - 248   2019

  • Utility of liquid biopsy using urine in patients with pancreatic ductal adenocarcinoma. Reviewed International journal

    Terasawa H, Kinugasa H, Ako S, Hirai M, Matsushita H, Uchida D, Tomoda T, Matsumoto K, Horiguchi S, Kato H, Nouso K, Okada H

    Cancer biology & therapy   20 ( 10 )   1348 - 1353   2019

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    In recent years, liquid biopsy for blood and body fluid in cancer patients has attracted attention. However, there have been few reports of liquid biopsy focusing on urine of pancreatic ductal adenocarcinoma (PDAC). In 56 patients with PDAC, DNA was extracted from urine and plasma prior to treatment, and KRAS mutations were analyzed with droplet digital PCR to examine the mutation detection rate. Our study showed that KRAS mutations were found in 27 cases (48%) in urine and 27 cases (48%) in plasma. The detection rate of urine KRAS mutations varied by renal functions. The rates were 70% (14/20) and 36% (13/36) in the creatinine clearance rate (CCr) < 70 mL/min group and in the CCr ≥ 70 mL/min group, respectively (P = .024). Whereas, no influence of the CCr was observed in the detection rates of plasma KRAS mutations. The rates were 50% (10/20) and 47% (17/36) in cases with the CCr < 70 mL/min group and the CCr ≥ 70 mL/min group, respectively. Although the sample size was small, this study clearly indicated a new possibility of less invasive urine liquid biopsy in PDAC patients.

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  • 近位空腸の異所性膵から発生した膵腺房細胞癌の1例

    石原 裕基, 内田 大輔, 加藤 博也, 松三 明宏, 皿谷 洋祐, 矢部 俊太郎, 高田 斎文, 室 信一郎, 友田 健, 松本 和幸, 堀口 繁, 岡田 裕之

    日本消化器病学会中国支部例会プログラム・抄録集   110回   124 - 124   2018.12

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  • IPMN診断における膵液細胞診 Liquid based cytologyの有用性ついての検討

    宮本 和也, 松本 和幸, 加藤 博也, 松三 明宏, 石原 裕基, 皿谷 洋祐, 矢部 俊太郎, 室 信一郎, 高田 斎文, 内田 大輔, 友田 健, 堀口 繁, 岡田 裕之

    日本消化器病学会中国支部例会プログラム・抄録集   110回   124 - 124   2018.12

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  • 肝門部悪性胆道狭窄に対してEUS下両葉ドレナージが有用であった1例

    内田 大輔, 加藤 博也, 松三 昭宏, 石原 裕基, 皿谷 洋祐, 高田 斎文, 室 信一郎, 友田 健, 松本 和幸, 堀口 繁, 岡田 裕之

    日本消化器病学会中国支部例会プログラム・抄録集   110回   148 - 148   2018.12

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  • Efficacy and safety of chemotherapy after endoscopic double stenting for malignant duodenal and biliary obstructions in patients with advanced pancreatic cancer: a single-institution retrospective analysis. Reviewed International journal

    Kazuyuki Matsumoto, Hironari Kato, Shigeru Horiguchi, Koichiro Tsutsumi, Yosuke Saragai, Saimon Takada, Sho Mizukawa, Shinichiro Muro, Daisuke Uchida, Takeshi Tomoda, Hiroyuki Okada

    BMC gastroenterology   18 ( 1 )   157 - 157   2018.10

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    BACKGROUND: Advanced pancreatic cancer is accompanied not only by bile duct obstruction, but also occasionally by duodenal obstruction. With new advances in chemotherapy and improvement in the management of stent dysfunction, the life expectancy of patients with pancreatic cancer has increased. This study aimed to evaluate the efficacy and safety of chemotherapy for advanced pancreatic cancer, as well as to analyze the prognostic factors, following endoscopic double stenting. METHODS: This retrospective study was conducted from January 1, 2007 to October 31, 2015 at an academic center. Fifty consecutive patients with pancreatic cancer who had undergone endoscopic double stenting, comprising duodenal and biliary stenting, were analyzed. We reviewed the patients records and analyzed the data of stent dysfunction rates after double stenting, reintervention for stent dysfunction, chemotherapy after double stenting, adverse events associated with chemotherapy after double stenting, survival times following double stenting, and overall survival times. The hospital's institutional review board for human research approved this study. RESULTS: The overall survival time and the survival time following double stenting were 10.9 months (IQR 6.0-18.4 months) and 2.4 months (IQR 1.4-5.2 months), respectively. After double stenting, duodenal stent dysfunction occurred in 6 patients (12%), and biliary stent dysfunction occurred in 12 patients (24%), respectively. All patients who experienced stent dysfunction underwent endoscopic reintervention, and all of the procedures were successful. Twenty-one (42%) patients were treated with chemotherapy post double stenting; 9 patients received chemotherapy as a first-line treatment, 9 as a second-line treatment, and 3 as a third-line treatment. During chemotherapy, 8 (38%) patients had grade 3-4 adverse events, which were manageable. Chemotherapy post double stenting (OR, 0.19; 95% CI, 0.059-0.60; P = .0051), reintervention for biliary stent dysfunction (OR, 0.21; 95% CI, 0.081-0.50; P = .0002), and performance status (< 2) (OR, 0.28; 95% CI, 0.098-0.71; P = .0064) were significant prognostic factors after double stenting. CONCLUSIONS: Systemic chemotherapy was manageable, even in patients with double stenting. Chemotherapy after double stenting and appropriate reintervention for stent obstructions potentially prolonged the survival of patients with advance pancreatic cancer.

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  • Dipeptide γ-secretase inhibitor treatment enhances the anti-tumor effects of cisplatin against gastric cancer by suppressing cancer stem cell properties. Reviewed International journal

    Ryo Kato, Masaya Iwamuro, Hidenori Shiraha, Shigeru Horiguchi, Emi Tanaka, Ken Matsumoto, Atsushi Ohyama, Hiroaki Sawahara, Teruya Nagahara, Daisuke Uchida, Koichiro Tsutsumi, Hiroyuki Okada

    Oncology letters   16 ( 4 )   5426 - 5432   2018.10

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    The γ-secretase inhibitor blocks Notch activity by preventing its cleavage at the cell surface. In the present study, the effect of the γ-secretase inhibitor on the viability of gastric cancer cells when administered in combination with cisplatin was investigated, with particular focus on CD44highLgr-5high cancer cells. The four gastric cancer cell lines, MKN45, MKN74, SC-6-JCK and SH-10-TC, were used for the experiments. In the MTT assay, treatment with 25 µM dipeptide γ-secretase inhibitor (DAPT) alone did not affect cell proliferation in any of the four cell lines. Gastric cancer cells subjected to combination treatment with DAPT and cisplatin exhibited decreased viability when compared with those treated with cisplatin alone. Flow cytometry was performed to evaluate the expression of cluster of differentiation (CD)-44 and leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr-5), two cancer stem cell markers in gastric cancers. Treatment with cisplatin alone significantly increased the proportion of CD44highLgr-5high cells. However, the addition of DAPT to cisplatin reduced the CD44highLgr-5high fraction, suggesting that DAPT reduced the number of gastric cancer cells. In conclusion, the present study demonstrated the synergistic effects of DAPT in combination with cisplatin by decreasing the survival of gastric cancer cells. In addition, combination treatment with DAPT reduced the number of CD44highLgr-5high cells, which are thought to exhibit cancer stem cell properties. These results highlight the therapeutic potential of DAPT in gastric cancer treatment.

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  • 当院における肝内胆管癌術後化学療法の検討

    高田 斎文, 堀口 繁, 岡田 裕之, 皿谷 洋祐, 水川 翔, 室 信一郎, 内田 大輔, 松本 和幸, 加藤 博也, 楳田 祐三, 八木 孝仁

    日本消化器病学会雑誌   115 ( 臨増大会 )   A772 - A772   2018.10

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  • 当院における出血ハイリスク総胆管結石症例に対する内視鏡治療

    皿谷 洋祐, 加藤 博也, 水川 翔, 高田 斎文, 室 信一郎, 内田 大輔, 友田 健, 松本 和幸, 堀口 繁, 岡田 裕之

    Gastroenterological Endoscopy   60 ( Suppl.2 )   2084 - 2084   2018.10

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  • IgG4陰性自己免疫性膵炎の臨床的特徴と長期予後についての検討

    室 信一郎, 堀口 繁, 加藤 博也, 皿谷 洋祐, 高田 斎文, 水川 翔, 内田 大輔, 友田 健, 松本 和幸, 植木 亨, 岡田 裕之

    日本消化器病学会雑誌   115 ( 臨増大会 )   A754 - A754   2018.10

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  • Beneficial and Paradoxical Roles of Anti-Oxidative Nutritional Support for Non-Alcoholic Fatty Liver Disease. Reviewed International journal

    Uchida D, Takaki A, Adachi T, Okada H

    Nutrients   10 ( 8 )   2018.7

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    Oxidative stress is being recognized as a key factor in the progression of chronic liver disease (CLD), especially non-alcoholic fatty liver disease (NAFLD). Many NAFLD treatment guidelines recommend the use of antioxidants, especially vitamin E. Many prospective studies have described the beneficial effects of such agents for the clinical course of NAFLD. However, as these studies are usually short-term evaluations, lasting only a few years, whether or not antioxidants continue to exert favorable long-term effects, including in cases of concomitant hepatocellular carcinoma, remains unclear. Antioxidants are generally believed to be beneficial for human health and are often commercially available as health-food products. Patients with lifestyle-related diseases often use such products to try to be healthier without practicing lifestyle intervention. However, under some experimental NAFLD conditions, antioxidants have been shown to encourage the progression of hepatocellular carcinoma, as oxidative stress is toxic for cancer cells, just as for normal cells. In this review, we will highlight the paradoxical effects of antioxidants against NAFLD and related hepatocellular carcinoma.

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  • The intra-conduit release method is useful for avoiding migration of metallic stents during EUS-guided hepaticogastrostomy (with video). Reviewed

    Daisuke Uchida, Hirofumi Kawamoto, Hironari Kato, Daisuke Goto, Takeshi Tomoda, Kazuyuki Matsumoto, Naoki Yamamoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hiroyuki Okada

    Journal of medical ultrasonics (2001)   45 ( 3 )   399 - 403   2018.7

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    PURPOSE: Although EUS-guided hepaticogastrostomy (EUS-HGS) with a covered self-expandable metal stent (SEMS) is a useful procedure, it is associated with severe adverse events, including stent migration. We, therefore, developed an intra-conduit release method, and investigated whether the technique yields a safer and more stable procedure. METHODS: The intra-conduit release method is a procedure to release the SEMS in the working channel conduit of the scope for anchoring between the liver and stomach to avoid stent migration. Forty-three patients who underwent EUS-HGS at two high-volume centers in Japan were enrolled in this retrospective study, and the safety and usefulness of this method were evaluated retrospectively. RESULTS: The intra-conduit release method was applied in 36 cases. The technical success rate of EUS-HGS with the intra-conduit release method was significantly higher in comparison with the conventional method. Additionally, the rate of early adverse events was significantly lower than that for the conventional method. CONCLUSION: The intra-conduit release method during EUS-HGS is useful for a stable procedure that avoids early adverse events.

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  • 膵癌術後再発に対するEUS-FNAの有用性 洗浄液を用いた遺伝子変異解析も含めて

    松本 和幸, 加藤 博也, 赤穂 宗一郎, 吉田 龍一, 楳田 祐三, 信岡 大輔, 皿谷 洋祐, 高田 斎文, 室 信一郎, 内田 大輔, 友田 健, 堀口 繁, 能祖 一裕, 八木 孝仁, 岡田 裕之

    膵臓   33 ( 3 )   516 - 516   2018.5

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  • 膵NET術後再発予測におけるダイナミックCTの有用性についての検討

    堀口 繁, 加藤 博也, 松本 和幸, 友田 健, 内田 大輔, 室 信一郎, 水川 翔, 高田 斎文, 皿谷 洋祐, 田中 顕之, 八木 孝仁, 岡田 裕之

    膵臓   33 ( 3 )   525 - 525   2018.5

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  • Re-intervention with endoscopic ultrasound-guided hepaticogastrostomy for unresectable hilar biliary drainage using a multipath occlusion balloon Reviewed

    Daisuke Uchida, Hironari Kato, Hiroyuki Okada

    Endoscopy   50 ( 4 )   450 - 452   2018.4

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    DOI: 10.1055/s-0044-100719

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  • 当院における超音波内視鏡下嚢胞ドレナージ術の現状

    内田 大輔, 加藤 博也, 皿谷 洋祐, 高田 斎文, 水川 翔, 室 信一郎, 友田 健, 松本 和幸, 堀口 繁, 岡田 裕之

    Gastroenterological Endoscopy   60 ( Suppl.1 )   737 - 737   2018.4

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  • Swing Tipを用いたERCPトラブルシューティング

    内田 大輔, 加藤 博也, 皿谷 洋祐, 高田 斎文, 水川 翔, 室 信一郎, 友田 健, 松本 和幸, 堀口 繁, 岡田 裕之

    Gastroenterological Endoscopy   60 ( Suppl.1 )   743 - 743   2018.4

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  • 当院における慢性膵炎に対する内視鏡治療戦略

    皿谷 洋祐, 内田 大輔, 水川 翔, 高田 斎文, 室 信一郎, 友田 健, 松本 和幸, 堀口 繁, 加藤 博也, 岡田 裕之

    Gastroenterological Endoscopy   60 ( Suppl.1 )   789 - 789   2018.4

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  • An Intrapancreatic Accessory Spleen That Was Difficult to Diagnose Due to Temporal Changes after Splenectomy. Reviewed

    Daisuke Uchida, Koichiro Tsutsumi, Hironari Kato, Hiroyuki Okada

    Internal medicine (Tokyo, Japan)   57 ( 5 )   681 - 685   2018.3

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    Accessory spleen (AS) is common anomaly, and 20% of AS cases occur in the pancreatic tail. An intrapancreatic AS can be difficult to distinguish from pancreatic neoplasms. In most cases, an AS is described as a hypervascular and solitary tumor, but an AS sometimes takes other forms. We herein report a rare case of an intrapancreatic AS with temporal changes in its appearance after splenectomy, which mimicked aspects of pancreatic cancer. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) and 99mTc sulfur colloid scintigraphy were useful for the diagnosis.

    DOI: 10.2169/internalmedicine.9271-17

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  • 切除不能膵癌に対するFOLFIRINOX/GEM+nabPTX投与の後治療についての検討

    水川 翔, 堀口 繁, 加藤 博也, 皿谷 洋祐, 高田 斎文, 室 信一郎, 内田 大輔, 松本 和幸, 友田 健, 岡田 裕之

    日本消化器病学会雑誌   115 ( 臨増総会 )   A305 - A305   2018.3

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  • Efficacy of endoscopic treatment using double-balloon enteroscopy for postoperative bile leakage in patients with hepaticojejunostomy. Reviewed International journal

    Kazuyuki Matsumoto, Koichiro Tsutsumi, Hironari Kato, Shigeru Horiguchi, Yosuke Saragai, Saimon Takada, Sho Mizukawa, Shinichiro Muro, Daisuke Uchida, Takeshi Tomoda, Hiroyuki Okada

    Endoscopy international open   6 ( 2 )   E211-E216 - E216   2018.2

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    Background and study aims  Endoscopic treatment for post-operative bile is technically challenging in patients with altered gastrointestinal anatomy. This study evaluated the effectiveness of using a short-type double-balloon enteroscope to treat postoperative bile leakage after hepaticojejunostomy.

    DOI: 10.1055/s-0043-125143

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  • 急性膵炎後fluid collectionに対する超音波内視鏡下嚢胞ドレナージの治療成績

    松三 明宏, 松本 和幸, 加藤 博也, 内田 大輔, 室 信一郎, 友田 健, 堀口 繁, 岡田 裕之

    日本内科学会雑誌   107 ( Suppl. )   233 - 233   2018.2

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  • Endoscopic balloon dilatation for benign hepaticojejunostomy anastomotic stricture using short double-balloon enteroscopy in patients with a prior Whipple's procedure: a retrospective study. Reviewed International journal

    Sho Mizukawa, Koichiro Tsutsumi, Hironari Kato, Shinichiro Muro, Yutaka Akimoto, Daisuke Uchida, Kazuyuki Matsumoto, Takeshi Tomoda, Shigeru Horiguchi, Hiroyuki Okada

    BMC gastroenterology   18 ( 1 )   14 - 14   2018.1

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    BACKGROUND: Endoscopic retrograde cholangiography using a short double-balloon endoscope (DB-ERC) is a promising minimally-invasive method for accessing hepaticojejunostomy (HJ) anastomosis in patients with surgically altered anatomy. We aimed to evaluate the immediate and long-term outcomes of balloon dilatation for benign HJ anastomotic stricture (HJAS) in patients who had previously undergone Whipple's procedure using a DB-ERC. METHODS: We conducted a retrospective analysis of 46 patients who underwent balloon dilatation alone with a DB-ERC for benign HJAS between November 2008 and November 2014. The median follow-up duration was 3.5 (interquartile range [IQR], 1.9-5.1) years. RESULTS: The technical and clinical success rates were 100%, and adverse events occurred in 7% (3/46, cholangitis). The median hospitalization period was seven (IQR, 5-10) days. Of 42 patients (91%) followed-up for > 1 year, 24 (51%) had recurrent HJAS at a median of 1.2 (IQR, 0.6-2.9) years after balloon dilatation. The cumulative anastomotic patency rates at 1, 2, and 3 years were 73, 55, and 49%, respectively. In univariate analysis, early stricture formation (< 1 year) was a risk factor for recurrent stenosis, although no statistically significant risk factors were observed in multivariate analysis. CONCLUSIONS: Endoscopic balloon dilatation with DB-ERC for benign HJAS is effective and safe, having good immediate technical success and few adverse events. Further improvements to this procedure are needed to prevent recurrent HJAS.

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  • Usefulness of a Cannula with a Flexible Tip (Swing Tip) for Managing Severe Biliary Stricture. Reviewed International journal

    Uchida D, Kato H, Saragai Y, Takada S, Muro S, Tomoda T, Matsumoto K, Horiguchi S, Okada H

    Canadian journal of gastroenterology & hepatology   2018   7125714 - 7125714   2018

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    Background and Aims: Biliary stenting for the treatment of biliary stricture is the most common indication of ERCP, but the procedure is sometimes unsuccessful because of severe strictures. The Swing Tip is useful for passing through severe strictures because it has a manually operable tip. The efficacy of using a Swing Tip was retrospectively evaluated. Methods: The 2353 patients who underwent ERCP for biliary stenting at our facility between January 2012 and July 2018 were enrolled. In all patients, procedures were begun using tapered tip-catheters, and Swing Tips were used if the procedure was found to be difficult with other devices. The indication for switching to the Swing Tip and the technical success rate were retrospectively evaluated. Results: A total of 99 patients (4.2%) underwent ERCP using the Swing Tip, including 49 patients for the selection of biliary branches and 50 for exchanging guidewires for rigid ones. In these patients, biliary stenting was successful in 22 patients (44.9%) and 45 patients (90%), respectively. The other 32 patients with failed endoscopic biliary drainage were treated via alternative approaches, such as percutaneous procedures, surgeries, or conservative treatments. There were no adverse events associated with the Swing Tip. Conclusion: The Swing Tip was technically feasible especially for exchanging guidewires during ERCP. Percutaneous procedures or surgical treatments can be avoided by using the Swing Tip. Ethical Statements: This study was approved by the institutional review board of Okayama University. All subjects provided informed consent. The study was registered in the UMIN protocol registration system (identification number UMIN 000033692).

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  • Indications for Endoscopic Ultrasound-Guided Pancreatic Drainage: For Benign or Malignant Cases? Reviewed

    Daisuke Uchida, Hironari Kato, Yosuke Saragai, Saimon Takada, Sho Mizukawa, Shinichiro Muro, Yutaka Akimoto, Takeshi Tomoda, Kazuyuki Matsumoto, Shigeru Horiguchi, Hiroyuki Okada

    Canadian Journal of Gastroenterology and Hepatology   2018   8216109   2018

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    DOI: 10.1155/2018/8216109

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  • Endoscopic Ultrasound-Guided Hepaticogastrostomy Is Effective for Repeated Recurrent Cholangitis after Surgery: Two Case Reports. Reviewed International journal

    Matsumi A, Kato H, Saragai Y, Mizukawa S, Takada S, Muro S, Uchida D, Tomoda T, Matsumoto K, Iwamuro M, Horiguchi S, Kawahara Y, Okada H

    Case reports in gastrointestinal medicine   2018   7201967 - 7201967   2018

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    We report the cases of two patients who underwent endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) using metallic stents (MS) for recurrent cholangitis due to benign biliary stenosis. The patients had repeatedly undergone double-balloon endoscopy and anastomotic stenosis. Thus, EUS-HGS was performed. The procedures were successful, and placement of a covered metallic stent (C-MS) relieved cholangitis. The occurrence of cholangitis was subsequently considerably reduced. For patients with postoperative recurrent cholangitis, EUS-HGS with MS should be considered because of its efficacy and safety.

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  • Recurrent bleeding from a hepatic artery pseudoaneurysm after biliary stent placement Reviewed

    Kenji Yamauchi, Daisuke Uchida, Hironari Kato, Hiroyuki Okada

    Internal Medicine   57 ( 1 )   49 - 52   2018

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    DOI: 10.2169/internalmedicine.8983-17

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  • Comparison of two fluoroscopic images to ensure efficient scope insertion for biliary intervention in patients with Roux-en-Y hepaticojejunostomy Reviewed

    Koichiro Tsutsumi, Hironari Kato, Ken Hirao, Sho Mizukawa, Shinichiro Muro, Yutaka Akimoto, Daisuke Uchida, Kazuyuki Matsumoto, Takeshi Tomoda, Shigeru Horiguchi, Shuntaro Yabe, Hiroyuki Seki, Yasuhiro Noma, Naoki Yamamoto, Ryo Harada, Tsuneyoshi Ogawa, Hiroyuki Okada

    ENDOSCOPY   49 ( 12 )   1256 - 1261   2017.12

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    DOI: 10.1055/s-0043-117406

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  • Usefulness of a newly designed plastic stent for endoscopic re-intervention in patients with malignant hilar biliary obstruction Reviewed

    Takeshi Tomoda, Hironari Kato, Hirofumi Kawamoto, Shinichiro Muro, Yutaka Akimoto, Daisuke Uchida, Kazuyuki Matsumoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hiroyuki Okada

    ENDOSCOPY   49 ( 11 )   1087 - 1091   2017.11

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    DOI: 10.1055/s-0043-116215

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  • Promising therapeutic efficacy of a novel reduced expression in immortalized cells/dickkopf-3 expressing adenoviral vector for hepatocellular carcinoma Reviewed

    Hiroaki Sawahara, Hidenori Shiraha, Daisuke Uchida, Hironari Kato, Ryo Kato, Atsushi Oyama, Teruya Nagahara, Masaya Iwamuro, Shigeru Horiguchi, Koichiro Tsutsumi, Mari Mandai, Tetsushige Mimura, Nozomu Wada, Yasuto Takeuchi, Kenji Kuwaki, Hideki Onishi, Shinichiro Nakamura, Masami Watanabe, Masakiyo Sakaguchi, Akinobu Takaki, Kazuhiro Nouso, Takahito Yagi, Yasutomo Nasu, Hiromi Kumon, Hiroyuki Okada

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   32 ( 10 )   1769 - 1777   2017.10

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  • 分枝型IPMNの手術適応について 国際診療ガイドラインの見直しも含めて

    室 信一郎, 加藤 博也, 水川 翔, 内田 大輔, 秋元 悠, 友田 健, 松本 和幸, 堀口 繁, 山本 直樹, 堤 康一郎, 岡田 裕之

    Gastroenterological Endoscopy   59 ( Suppl.2 )   2183 - 2183   2017.9

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  • Techniques for scope insertion by utilizing the "suture line on the jejunojejunostomy" in balloon enteroscopeassisted ercp in patients with surgically altered anatomies

    Koichiro Tsutsumi, Hironari Kato, Shigeru Horiguchi, Kazuyuki Matsumoto, Takeshi Tomoda, Daisuke Uchida, Yutaka Akimoto, Shinichiro Muro, Sho Mizukawa, Hiroyuki Okada

    Gastroenterological Endoscopy   59 ( 8 )   1644 - 1652   2017.8

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  • A Multicenter, Prospective, Randomized Controlled Trial Evaluating the Efficacy of Rectal Diclofenac and Sublingual Nitroglycerin as a Combined Prophylactic Treatment for Post-ERCP Pancreatitis (vol 70, pg 405, 2016) Reviewed

    Takeshi Tomoda, Hironari Kato, Sho Mizukawa, Shinichiro Muro, Yutaka Akimoto, Daisuke Uchida, Kazuyuki Matsumoto, Naoki Yamamoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hiroyuki Okada

    ACTA MEDICA OKAYAMA   71 ( 4 )   357 - +   2017.8

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  • Long-term outcomes and risk factors of biliary stent dysfunction after endoscopic double stenting for malignant biliary and duodenal obstructions Reviewed

    Kazuyuki Matsumoto, Hironari Kato, Koichiro Tsutsumi, Sho Mizukawa, Syuntaro Yabe, Hiroyuki Seki, Yutaka Akimoto, Daisuke Uchida, Takeshi Tomoda, Naoki Yamamoto, Shigeru Horiguchi, Kenji Kuwaki, Hiroyuki Okada

    DIGESTIVE ENDOSCOPY   29 ( 5 )   617 - 625   2017.7

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    DOI: 10.1111/den.12830

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  • Association between periodontitis and prognosis of pancreatobiliary tract cancer: A pilot study. Reviewed International journal

    Takayuki Maruyama, Takaaki Tomofuji, Tatsuya Machida, Hironari Kato, Koichiro Tsutsumi, Daisuke Uchida, Akinobu Takaki, Toshiki Yoneda, Hisataka Miyai, Hirofumi Mizuno, Daisuke Ekuni, Hiroyuki Okada, Manabu Morita

    Molecular and clinical oncology   6 ( 5 )   683 - 687   2017.5

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    Several studies have indicated that periodontitis is a risk factor for cancer. However, the association between periodontitis and the prognosis of pancreatobiliary tract cancer remains unclear. The aim of this pilot study was to investigate the association between periodontitis and prognosis of pancreatobiliary tract cancer. A total of 22 patients diagnosed with pancreatobiliary tract cancer were analyzed. Oral health status, including severity of periodontitis, general health status and biochemical serum markers were evaluated. The Kaplan-Meier method and Cox proportional hazards model were used to assess factors affecting the prognosis of pancreatobiliary tract cancer. The Kaplan-Meier analysis demonstrated that low body mass index, high concentration of serum C-reactive protein (CRP) and severe periodontitis were significant prognostic factors for survival rate. The Cox proportional hazards model revealed that serum carbohydrate antigen 19-9 concentration [hazard ratio (HR)=1.002; 95% confidence interval (CI): 1.000-1.004] and serum CRP concentration (HR=2.57; 95% CI: 1.15-5.74) were significantly associated with the prognosis of pancreatobiliary tract cancer. In addition, cancer patients with severe periodontitis had higher serum CRP concentrations compared with those without severe periodontitis. Therefore, severe periodontitis indirectly affected the prognosis of pancreatobiliary tract cancer through promoting systemic inflammation.

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  • Predictive factors for outcomes of patients undergoing endoscopic therapy for bile leak after hepatobiliary surgery Reviewed

    Shuntaro Yabe, Hironari Kato, Sho Mizukawa, Yutaka Akimoto, Daisuke Uchida, Hiroyuki Seki, Takeshi Tomoda, Kazuyuki Matsumoto, Naoki Yamamoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hiroyuki Okada

    DIGESTIVE ENDOSCOPY   29 ( 3 )   353 - 361   2017.5

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  • 膵NETの診療ガイドラインの問題点と今後の展望 PNET術後再発予測因子に関する検討

    堀口 繁, 加藤 博也, 水川 翔, 室 信一郎, 内田 大輔, 友田 健, 松本 和幸, 田中 顕之, 八木 孝仁, 岡田 裕之

    膵臓   32 ( 3 )   402 - 402   2017.5

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  • 急性膵炎の後期合併症に対する手術・インターベンション治療の現状と課題 急性膵炎後fluid collectionに対する超音波内視鏡下嚢胞ドレナージ術の現状

    内田 大輔, 加藤 博也, 水川 翔, 室 信一郎, 秋元 悠, 友田 健, 松本 和幸, 堀口 繁, 堤 康一郎, 岡田 裕之

    膵臓   32 ( 3 )   448 - 448   2017.5

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  • 超音波内視鏡を用いた膵疾患診療 基本から応用まで 閉塞性膵炎に対するEUS下膵管ドレナージの有用性に関する検討

    友田 健, 加藤 博也, 水川 翔, 室 信一郎, 秋元 悠, 内田 大輔, 松本 和幸, 堀口 繁, 堤 康一郎

    膵臓   32 ( 3 )   330 - 330   2017.5

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  • Suitable Liquid Biopsy Samples for Detecting Kras Mutations in Patients with Pancreatic Cancer Reviewed

    Soichiro Ako, Kazuhiro Nouso, Hideaki Kinugasa, Chihiro Dohi, Hiroshi Matsushita, Sho Mizukawa, Shinichiro Muro, Yutaka Akimoto, Daisuke Uchida, Takeshi Tomoda, Kazuyuki Matsumoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hironari Kato, Hiroyuki Okada

    Gastroenterology   152 ( 5 )   S490   2017.4

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  • Dynamic computed tomography is useful for prediction of pathological grade in pancreatic neuroendocrine neoplasm Reviewed

    Shigeru Horiguchi, Hironari Kato, Hidenori Shiraha, Koichiro Tsutsumi, Naoki Yamamoto, Kazuyuki Matsumoto, Takeshi Tomoda, Daisuke Uchida, Yutaka Akimoto, Syou Mizukawa, Takehiro Tanaka, Koichi Ichimura, Akinobu Takaki, Takahito Yagi, Hiroyuki Okada

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   32 ( 4 )   925 - 931   2017.4

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  • 当院におけるEUS下胆道ドレナージの現状

    内田 大輔, 加藤 博也, 岡田 裕之, 水川 翔, 室 信一郎, 秋元 悠, 友田 健, 松本 和幸, 堀口 繁, 堤 康一郎

    Gastroenterological Endoscopy   59 ( Suppl.1 )   994 - 994   2017.4

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  • 経乳頭的に留置した胆管・膵管ステントの迷入症例の検討

    室 信一郎, 加藤 博也, 水川 翔, 秋元 悠, 内田 大輔, 友田 健, 松本 和幸, 堀口 繁, 堤 康一郎, 岡田 裕之

    Gastroenterological Endoscopy   59 ( Suppl.1 )   1091 - 1091   2017.4

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  • Redox Signaling in NASH Reviewed

    A. Takaki, D. Uchida, K. Yamamoto

    Liver Pathophysiology: Therapies and Antioxidants   169 - 180   2017.3

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    DOI: 10.1016/B978-0-12-804274-8.00012-6

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  • Loss of Runt-related transcription factor 3 induces resistance to 5-fluorouracil and cisplatin in hepatocellular carcinoma (vol 35, pg 2576, 2016) Reviewed

    Junro Kataoka, Hidenori Shiraha, Shigeru Horiguchi, Hiroaki Sawahara, Daisuke Uchida, Teruya Nagahara, Masaya Iwamuro, Hiroki Morimoto, Yasuto Takeuchi, Kenji Kuwaki, Hideki Onishi, Shinichiro Nakamura, Akinobu Takaki, Kazuhiro Nouso, Takahito Yagi, Kazuhide Yamamoto, Hiroyuki Okada

    ONCOLOGY REPORTS   37 ( 3 )   1921 - 1921   2017.3

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  • Utility of serum DNA as a marker for KRAS mutations in pancreatic cancer tissue Reviewed

    Soichiro Ako, Kazuhiro Nouso, Hideaki Kinugasa, Chihiro Dohi, Hiroshi Matushita, Sho Mizukawa, Shinichiro Muro, Yutaka Akimoto, Daisuke Uchida, Takeshi Tomoda, Kazuyuki Matsumoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hironari Kato, Hiroyuki Okada

    PANCREATOLOGY   17 ( 2 )   285 - 290   2017.3

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    DOI: 10.1016/j.pan.2016.12.011

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  • Oxidative stress in nonalcoholic steatohepatitis

    Akinobu Takaki, Daisuke Uchida, Kazuhide Yamamoto

    Reactive Oxygen Species in Biology and Human Health   349 - 361   2017.1

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    DOI: 10.1201/b20228

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  • A comparative evaluation of treatment methods for bile duct stones after hepaticojejunostomy between percutaneous transhepatic cholangioscopy and peroral, short double-balloon enteroscopy Reviewed

    Koichiro Tsutsumi, Hironari Kato, Shuntaro Yabe, Sho Mizukawa, Hiroyuki Seki, Yutaka Akimoto, Daisuke Uchida, Kazuyuki Matsumoto, Takeshi Tomoda, Naoki Yamamoto, Shigeru Horiguchi, Hirofumi Kawamoto, Hiroyuki Okada

    THERAPEUTIC ADVANCES IN GASTROENTEROLOGY   10 ( 1 )   54 - 67   2017.1

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    DOI: 10.1177/1756283X16674633

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  • The Serum Oxidative/Anti-oxidative Stress Balance Becomes Dysregulated in Patients with Non-alcoholic Steatohepatitis Associated with Hepatocellular Carcinoma Reviewed

    Yasuyuki Shimomura, Akinobu Takaki, Nozomu Wada, Tetsuya Yasunaka, Fusao Ikeda, Takayuki Maruyama, Naofumi Tamaki, Daisuke Uchida, Hideki Onishi, Kenji Kuwaki, Shinichiro Nakamura, Kazuhiro Nouso, Yasuhiro Miyake, Kazuko Koike, Takaaki Tomofuji, Manabu Morita, Kazuhide Yamamoto, Hiroyuki Okada

    INTERNAL MEDICINE   56 ( 2 )   243 - 251   2017

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    DOI: 10.2169/internalmedicine.56.7002

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  • The serum oxidative/anti-oxidative stress balance becomes dysregulated in patients with non-alcoholic steatohepatitis associated with hepatocellular carcinoma Reviewed

    Yasuyuki Shimomura, Akinobu Takaki, Nozomu Wada, Tetsuya Yasunaka, Fusao Ikeda, Takayuki Maruyama, Naofumi Tamaki, Daisuke Uchida, Hideki Onishi, Kenji Kuwaki, Shinichiro Nakamura, Kazuhiro Nouso, Yasuhiro Miyake, Kazuko Koike, Takaaki Tomofuji, Manabu Morita, Kazuhide Yamamoto, Hiroyuki Okada

    Internal Medicine   56 ( 3 )   243 - 251   2017

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    DOI: 10.2169/internalmedicine.56.7002

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  • Outcomes of management for biliary stricture after living donor liver transplantation with hepaticojejunostomy using short-type double-balloon enteroscopy Reviewed

    Takeshi Tomoda, Koichiro Tsutsumi, Hironari Kato, Sho Mizukawa, Syuntaro Yabe, Yutaka Akimoto, Hiroyuki Seki, Daisuke Uchida, Kazuyuki Matsumoto, Naoki Yamamoto, Shigeru Horiguchi, Hiroyuki Okada

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   30 ( 12 )   5338 - 5344   2016.12

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    DOI: 10.1007/s00464-016-4886-x

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  • 膵癌との鑑別を要した膵内副脾の一例

    堤 康一郎, 加藤 博也, 堀口 繁, 山本 直樹, 友田 健, 松本 和幸, 秋元 悠, 内田 大輔, 室 信一郎, 岡田 裕之

    超音波医学   43 ( 6 )   777 - 777   2016.11

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  • A Prospective Randomized Controlled Study Comparing EUS Sonopsy CY(R) and 22-gauge Biopsy Needles for Endoscopic Ultrasound-guided Fine-Needle Aspiration of Solid Pancreatic Mass Lesions Reviewed

    Sho Mizukawa, Hironari Kato, Shinichiro Muro, Yutaka Akimoto, Daisuke Uchida, Takeshi Tomoda, Kazuyuki Matsumoto, Naoki Yamamoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hiroyuki Okada, Hirofumi Inoue, Noriyuki Tanaka

    ACTA MEDICA OKAYAMA   70 ( 5 )   417 - 420   2016.10

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    DOI: 10.18926/AMO/54605

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  • A Multicenter, Prospective, Randomized Controlled Trial Evaluating the Efficacy of Rectal Diclofenac and Sublingual Nitroglycerin as a Combined Prophylactic Treatment for Post-ERCP Pancreatitis Reviewed

    Takeshi Tomoda, Hironari Kato, Sho Mizukawa, Shinichiro Muro, Yutaka Akimoto, Daisuke Uchida, Kazuyuki Matsumoto, Naoki Yamamoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hiroyuki Okada

    ACTA MEDICA OKAYAMA   70 ( 5 )   405 - 408   2016.10

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    DOI: 10.18926/AMO/54602

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  • miR-1246 and miR-4644 in salivary exosome as potential biomarkers for pancreatobiliary tract cancer Reviewed

    Tatsuya Machida, Takaaki Tomofuji, Takayuki Maruyama, Toshiki Yoneda, Daisuke Ekuni, Tetsuji Azuma, Hisataka Miyai, Hirofumi Mizuno, Hironari Kato, Koichiro Tsutsumi, Daisuke Uchida, Akinobu Takaki, Hiroyuki Okada, Manabu Morita

    ONCOLOGY REPORTS   36 ( 4 )   2375 - 2381   2016.10

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    DOI: 10.3892/or.2016.5021

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  • 術後胆汁漏に対する内視鏡的胆管ドレナージ術の有用性の検討

    矢部 俊太郎, 加藤 博也, 水川 翔, 秋元 悠, 内田 大輔, 關 博之, 友田 健, 松本 和幸, 山本 直樹, 堀口 繁, 堤 康一郎

    Gastroenterological Endoscopy   58 ( Suppl.2 )   1934 - 1934   2016.10

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  • ERCP関連処置合併症に対するcovered self-expandable metallic stentの有用性

    水川 翔, 加藤 博也, 矢部 俊太郎, 秋元 悠, 關 博之, 内田 大輔, 友田 健, 松本 和幸, 堀口 繁, 山本 直樹, 堤 康一郎, 岡田 裕之

    Gastroenterological Endoscopy   58 ( Suppl.2 )   1930 - 1930   2016.10

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  • PNETの診断治療に関する検討

    堀口 繁, 加藤 博也, 水川 翔, 矢部 俊太郎, 内田 大輔, 秋元 悠, 關 博之, 松本 和幸, 友田 健, 山本 直樹, 堤 康一郎, 岡田 裕之

    日本消化器病学会雑誌   113 ( 臨増大会 )   A676 - A676   2016.9

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  • Diagnosing Pancreatic Tumors Using Contrast-enhanced Harmonic Endoscopic Ultrasonography with Sonazoid Reviewed

    Naoki Yamamoto, Hironari Kato, Sho Mizukawa, Shinichiro Muro, Yutaka Akimoto, Daisuke Uchida, Takeshi Tomoda, Kazuyuki Matsumoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hiroyuki Okada

    ACTA MEDICA OKAYAMA   70 ( 4 )   323 - 325   2016.8

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    DOI: 10.18926/AMO/54513

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  • Efficacy and Safety of Endoscopic Ultrasound-guided Ethanol Ablation Therapy for Pancreatic Neuroendocrine Tumors Reviewed

    Kazuyuki Matsumoto, Hironari Kato, Koichiro Tsutsumi, Sho Mizukawa, Syuntaro Yabe, Hiroyuki Seki, Yutaka Akimoto, Daisuke Uchida, Takeshi Tomoda, Naoki Yamamoto, Shigeru Horiguchi, Hiroyuki Okada

    ACTA MEDICA OKAYAMA   70 ( 4 )   313 - 316   2016.8

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    DOI: 10.18926/AMO/54511

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  • 化学療法を施行した胆嚢NECの3例

    堀口 繁, 加藤 博也, 水川 翔, 室 信一郎, 内田 大輔, 秋元 悠, 松本 和幸, 友田 健, 山本 直樹, 堤 康一郎, 岡田 裕之

    胆道   30 ( 3 )   562 - 562   2016.8

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  • 術後再建腸管を有する膵胆道疾患に対する新たなダブルバルーン内視鏡(EI-580BT)の有用性に関する検討

    友田 健, 堤 康一郎, 水川 翔, 室 信一郎, 内田 大輔, 秋元 悠, 松本 和幸, 山本 直樹, 堀口 繁, 加藤 博也, 岡田 裕之

    胆道   30 ( 3 )   527 - 527   2016.8

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  • Endoscopic ultrasonography-guided drainage of intra-abdominal fluid collection after liver transplantation: a case series of six patients Reviewed

    Daisuke Uchida, Koichiro Tsutsumi, Hironari Kato, Hiroyuki Okada

    JOURNAL OF MEDICAL ULTRASONICS   43 ( 3 )   421 - 426   2016.7

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    DOI: 10.1007/s10396-016-0720-2

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  • Biliary Anastomotic Stricture After Adult Living Donor Liver Transplantation With Duct-to-Duct Reconstruction: Outcome After Endoscopic Treatment Including Rendezvous Procedure Reviewed

    Takeshi Tomoda, Hironari Kato, Sho Mizukawa, Syuntaro Yabe, Yutaka Akimoto, Hiroyuki Seki, Daisuke Uchida, Kazuyuki Matsumoto, Naoki Yamamoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hiroyuki Okada

    TRANSPLANTATION   100 ( 7 )   1500 - 1506   2016.7

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    DOI: 10.1097/TP.0000000000001187

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  • Synergistic anti-pancreatic cancer immunological effects by treatment with reduced expression in immortalized cells/dickkopf-3 protein and peripheral blood mononuclear cells Reviewed

    Daisuke Uchida, Hidenori Shiraha, Hironari Kato, Hiroaki Sawahara, Teruya Nagahara, Masaya Iwamuro, Junro Kataoka, Shigeru Horiguchi, Masami Watanabe, Akinobu Takaki, Kazuhiro Nouso, Yasutomo Nasu, Hiromi Kumon, Kazuhide Yamamoto

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31 ( 6 )   1154 - 1159   2016.6

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    DOI: 10.1111/jgh.13259

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  • Loss of Runt-related transcription factor 3 induces resistance to 5-fluorouracil and cisplatin in hepatocellular carcinoma Reviewed

    Junro Kataoka, Hidenori Shiraha, Shigeru Horiguchi, Hiroaki Sawahara, Daisuke Uchida, Teruya Nagahara, Masaya Iwamuro, Hiroki Morimoto, Yasuto Takeuchi, Kenji Kuwaki, Hideki Onishi, Shinichiro Nakamura, Akinobu Takaki, Kazuhiro Nouso, Takahito Yagi, Kazuhide Yamamoto, Hiroyuki Okada

    ONCOLOGY REPORTS   35 ( 5 )   2576 - 2582   2016.5

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    DOI: 10.3892/or.2016.4681

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  • Promising Therapeutic Efficacy of a Novel REIC/Dkk-3 Expressing Adenoviral Vector for Hepatocellular Carcinoma Reviewed

    Sawahara Hiroaki, Hidenori Shiraha, Daisuke Uchida, Masakiyo Sakaguchi, Masami Watanabe, Yasutomo Nasu, Hiromi Kumon, Hiroyuki Okada

    GASTROENTEROLOGY   150 ( 4 )   S1153 - S1153   2016.4

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  • Development of a Novel REIC/DKK-3-Encoding Adenoviral Agent: Its Robust and Promising Therapeutic Effects in Pancreatic Cancer Reviewed

    Daisuke Uchida, Hidenori Shiraha, Hironari Kato, Sawahara Hiroaki, Masakiyo Sakaguchi, Masami Watanabe, Yasutomo Nasu, Hiromi Kumon, Hiroyuki Okada

    GASTROENTEROLOGY   150 ( 4 )   S294 - S294   2016.4

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  • Effectiveness of peroral direct cholangioscopy using an ultraslim endoscope for the treatment of hepatolithiasis in patients with hepaticojejunostomy (with video) Reviewed

    Kazuyuki Matsumoto, Koichiro Tsutsumi, Hironari Kato, Yutaka Akimoto, Daisuke Uchida, Takeshi Tomoda, Naoki Yamamoto, Yasuhiro Noma, Shigeru Horiguchi, Hiroyuki Okada, Kazuhide Yamamoto

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   30 ( 3 )   1249 - 1254   2016.3

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    DOI: 10.1007/s00464-015-4323-6

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  • Oxidative stress balance is dysregulated and represents an additional target for treating cholangiocarcinoma Reviewed

    Daisuke Uchida, Akinobu Takaki, Hisashi Ishikawa, Yasuko Tomono, Hironari Kato, Koichiro Tsutsumi, Naofumi Tamaki, Takayuki Maruyama, Takaaki Tomofuji, Ryuichiro Tsuzaki, Tetsuya Yasunaka, Kazuko Koike, Hiroshi Matsushita, Fusao Ikeda, Yasuhiro Miyake, Hidenori Shiraha, Kazuhiro Nouso, Ryuichi Yoshida, Yuzo Umeda, Susumu Shinoura, Takahito Yagi, Toshiyoshi Fujiwara, Manabu Morita, Masaki Fukushima, Kazuhide Yamamoto, Hiroyuki Okada

    FREE RADICAL RESEARCH   50 ( 7 )   732 - 743   2016

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    DOI: 10.3109/10715762.2016.1172071

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  • Pancreatic Hepatoid Carcinoma Mimicking a Solid Pseudopapillary Neoplasm: A Challenging Case on Endoscopic Ultrasound-guided Fine-needle Aspiration Reviewed

    Yutaka Akimoto, Hironari Kato, Kazuyuki Matsumoto, Ryo Harada, Shinsuke Oda, Soichiro Fushimi, Shou Mizukawa, Shuntaro Yabe, Daisuke Uchida, Hiroyuki Seki, Takeshi Tomoda, Naoki Yamamoto, Shigeru Horiguchi, Koichiro Tsutsumi, Takahito Yagi, Hiroyuki Okada

    INTERNAL MEDICINE   55 ( 17 )   2405 - 2411   2016

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    DOI: 10.2169/internalmedicine.55.6741

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  • [Radical surgery after successful chemotherapy in a case of primary small cell carcinoma of the liver]. Reviewed

    Yutaka Akimoto, Koichiro Tsutsumi, Hironari Kato, Hidenori Hata, Hiroyuki Sakae, Daisuke Uchida, Takeshi Tomoda, Kazuyuki Matsumoto, Yasuhiro Noma, Naoki Yamamoto, Shigeru Horiguchi, Ryo Harada, Hiroyuki Okada, Hiroyuki Yanai, Takahito Yagi, Kazuhide Yamamoto

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   112 ( 11 )   2024 - 34   2015.11

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    A 52-year-old woman was admitted to our hospital with right upper quadrant pain with gallbladder wall thickening and multiple liver tumors. Endoscopic ultrasound-guided biopsy revealed small cell carcinomas of both the gallbladder and liver. After 10 cycles of chemotherapy with etoposide and cisplatin, marked shrinkage of the tumors was evident on computed tomography. The patient subsequently underwent hepatectomy and resection of the extrahepatic bile duct and gallbladder with curative intent. Although no viable tumor cells were found in the resected specimens, we confirmed phagocytosis of tumor cells killed by chemotherapy in the resected liver specimen. Therefore, we suspected that the patient had primary small cell carcinoma of the liver that had been successfully treated. This is a rare case of primary small cell carcinoma of the liver that showed pathological complete response to chemotherapy with etoposide and cisplatin.

    DOI: 10.11405/nisshoshi.112.2024

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  • 当院における生体肝移植後の胆管狭窄に対する内視鏡治療

    友田 健, 加藤 博也, 内田 大輔, 秋元 悠, 松本 和幸, 山本 直樹, 堀口 繁, 堤 康一郎, 高木 章乃夫, 岡田 裕之, 八木 孝仁

    移植   50 ( 4-5 )   481 - 481   2015.10

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  • Hepatic stellate cells promote upregulation of epithelial cell adhesion molecule and epithelial-mesenchymal transition in hepatic cancer cells Reviewed

    Teruya Nagahara, Hidenori Shiraha, Hiroaki Sawahara, Daisuke Uchida, Yasuto Takeuchi, Masaya Iwamuro, Junro Kataoka, Shigeru Horiguchi, Takeshi Kuwaki, Hideki Onishi, Shinichiro Nakamura, Akinobu Takaki, Kazuhiro Nouso, Kazuhide Yamamoto

    ONCOLOGY REPORTS   34 ( 3 )   1169 - 1177   2015.9

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    DOI: 10.3892/or.2015.4126

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  • Walled-off necrosisに対するstep-up approachによる内視鏡的治療成績

    秋元 悠, 加藤 博也, 松本 和幸, 内田 大輔, 友田 健, 山本 直樹, 堀口 繁, 堤 康一郎, 岡田 裕之

    Gastroenterological Endoscopy   57 ( Suppl.2 )   2209 - 2209   2015.9

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  • 当院におけるmodified FOLFIRINOXの治療成績についての検討

    堀口 繁, 加藤 博也, 水川 翔, 矢部 俊太郎, 關 博之, 秋元 悠, 内田 大輔, 友田 健, 松本 和幸, 山本 直樹, 堤 康一郎, 那須 淳一郎, 岡田 裕之, 山本 和秀

    日本消化器病学会雑誌   112 ( 臨増大会 )   A899 - A899   2015.9

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  • デバイス突破を目的としたSoehendra stent retrieverを用いた拡張術

    松本 和幸, 加藤 博也, 堤 康一郎, 秋元 悠, 内田 大輔, 友田 健, 山本 直樹, 堀口 繁, 岡田 裕之

    Gastroenterological Endoscopy   57 ( Suppl.2 )   2200 - 2200   2015.9

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  • 胆管空腸吻合術後の肝内結石治療における細径内視鏡を用いた経口直接胆道鏡の有用性

    松本 和幸, 堤 康一郎, 加藤 博也, 秋元 悠, 内田 大輔, 友田 健, 山本 直樹, 堀口 繁, 八木 孝仁, 岡田 裕之

    胆道   29 ( 3 )   503 - 503   2015.8

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  • Efficacy of Endoscopic Over 3-branched Partial Stent-in-Stent Drainage Using Self-expandable Metallic Stents in Patients With Unresectable Hilar Biliary Carcinoma Reviewed

    Daisuke Uchida, Hironari Kato, Shinichiro Muro, Yasuhiro Noma, Naoki Yamamoto, Shigeru Horiguchi, Ryo Harada, Koichiro Tsutsumi, Hirofumi Kawamoto, Hiroyuki Okada, Kazuhide Yamamoto

    JOURNAL OF CLINICAL GASTROENTEROLOGY   49 ( 6 )   529 - 536   2015.7

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    DOI: 10.1097/MCG.0000000000000213

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  • Successful biliary drainage using a metal stent through the gastric stoma Reviewed

    Kazuyuki Matsumoto, Hironari Kato, Koichiro Tsutsumi, Yutaka Akimoto, Daisuke Uchida, Takeshi Tomoda, Naoki Yamamoto, Yasuhiro Noma, Shigeru Horiguchi, Hiroyuki Okada, Kazuhide Yamamoto

    WORLD JOURNAL OF GASTROENTEROLOGY   21 ( 24 )   7594 - 7597   2015.6

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    DOI: 10.3748/wjg.v21.i24.7594

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  • PNETの集学的治療 当院及び関連病院におけるPNET治療についての検討

    堀口 繁, 加藤 博也, 秋元 悠, 内田 大輔, 松本 和幸, 友田 健, 野間 康宏, 山本 直樹, 堤 康一郎, 伏見 聡一郎, 藤井 雅邦, 植木 亨, 八木 孝仁, 山本 和秀

    膵臓   30 ( 3 )   320 - 320   2015.5

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  • 膵疾患の分子病態 Basics and Applications 網羅的糖鎖解析によるIPMNの悪性度診断能の検討

    秋元 悠, 能祖 一裕, 加藤 博也, 宮原 孝治, 内田 大輔, 友田 健, 松本 和幸, 野間 康宏, 山本 直樹, 堀口 繁, 堤 康一郎, 岡田 裕之, 山本 和秀

    膵臓   30 ( 3 )   268 - 268   2015.5

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  • 胆管空腸吻合術後の肝内結石治療に対するDB-ERCPの有用性と工夫

    堤 康一郎, 加藤 博也, 内田 大輔, 秋元 悠, 友田 健, 松本 和幸, 野間 康宏, 山本 直樹, 堀口 繁, 岡田 裕之, 山本 和秀

    Gastroenterological Endoscopy   57 ( Suppl.1 )   765 - 765   2015.4

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  • 巨大結石に対するEPLBDの有用性及び安全性の検討 超高齢者に対してもEPLBDは安全に施行可能か?

    友田 健, 加藤 博也, 秋元 悠, 内田 大輔, 松本 和幸, 野間 康宏, 山本 直樹, 堀口 繁, 堤 康一郎, 岡田 裕之, 山本 和秀

    Gastroenterological Endoscopy   57 ( Suppl.1 )   740 - 740   2015.4

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  • Potential of adenovirus-mediated REIC/Dkk-3 gene therapy for use in the treatment of pancreatic cancer Reviewed

    Daisuke Uchida, Hidenori Shiraha, Hironari Kato, Teruya Nagahara, Masaya Iwamuro, Junro Kataoka, Shigeru Horiguchi, Masami Watanabe, Akinobu Takaki, Kazuhiro Nouso, Yasutomo Nasu, Takahito Yagi, Hiromi Kumon, Kazuhide Yamamoto

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   29 ( 5 )   973 - 983   2014.5

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    DOI: 10.1111/jgh.12501

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  • Effect of hepatic arterial infusion chemotherapy of 5-fluorouracil and cisplatin for advanced hepatocellular carcinoma in the nationwide survey of primary liver cancer in Japan Reviewed

    K. Nouso, K. Miyahara, D. Uchida, K. Kuwaki, N. Izumi, M. Omata, T. Ichida, M. Kudo, Y. Ku, N. Kokudo, M. Sakamoto, O. Nakashima, T. Takayama, O. Matsui, Y. Matsuyama, K. Yamamoto

    British Journal of Cancer   109 ( 7 )   1904 - 1907   2013.10

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    DOI: 10.1038/bjc.2013.542

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  • 当院におけるTherapeutic EUSの現状

    内田 大輔, 加藤 博也, 友田 健, 松本 和幸, 榊原 一郎, 山本 直樹, 野間 康弘, 園山 隆之, 堤 康一郎, 山本 和秀

    Gastroenterological Endoscopy   54 ( Suppl.2 )   2780 - 2780   2012.9

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  • A case of celiac artery dissection diagnosed with EUS Reviewed

    Daisuke Uchida, Kazuhiro Nouso, Hironari Kato, Koichiro Tsutsumi, Kazuhide Yamamoto

    GASTROINTESTINAL ENDOSCOPY   76 ( 2 )   424 - 424   2012.8

  • Classification of the bleeding pattern in colonic diverticulum is useful to predict the risk of bleeding or re-bleeding after endoscopic treatment Reviewed

    Yoko Kominami, Hirotoki Ohe, Sayo Kobayashi, Reiji Higashi, Daisuke Uchida, Yuki Morimoto, Asuka Nakarai, Norifumi Numata, Ken Hirao, Tsuneyoshi Ogawa, Toru Ueki, Masahiro Nakagawa, Yasuyuki Araki, Motowo Mizuno, Kazuaki Chayama

    Journal of Japanese Society of Gastroenterology   109 ( 3 )   393 - 399   2012.3

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  • Cerebral sinus thrombosis complicating ulcerative colitis Reviewed

    Asuka Nakarai, Ohe Hirotoki, Daisuke Uchida, Norifumi Numata, Yoko Kominami, Hiroshi Matsushita, Shintaro Nanba, Ota Shigeru, Tsuneyoshi Ogawa, Manabu Kurome, Toru Ueki, Masahiro Nakagawa, Yasuyuki Araki, Motowo Mizuno

    Journal of Japanese Society of Gastroenterology   108 ( 3 )   451 - 457   2011.3

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  • Dynamic computed tomography is useful for the diagnosis and colonoscopic treatment of colonic diverticular bleeding Reviewed

    Yoko Kominami, Hirotoki Ohe, Sayo Kobayashi, Daisuke Uchida, Norifumi Numata, Hiroshi Matsushita, Yuki Morimoto, Asuka Nakarai, Shintarou Nanba, Shigeru Ohta, Tsuneyoshi Ogawa, Manabu Kurome, Toru Ueki, Masahiro Nakagawa, Yasuyuki Araki, Motowo Mizuno

    Journal of Japanese Society of Gastroenterology   108 ( 2 )   223 - 230   2011.2

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  • A case of gangliocytic paraganglioma with lymphoid metastasis Reviewed

    Daisuke Uchida, Tsuneyoshi Ogawa, Toru Ueki, Yoko Kominami, Norifumi Numata, Hiroshi Matsusita, Yuki Morimoto, Asuka Nakarai, Shigeru Ota, Shintaro Nanba, Shinichi Takada, Shota Iwado, Manabu Kurome, Hirotoki Ohe, Ryoichi Okamoto, Syuji Uematsu, Masahiro Nakagawa, Kiyotaka Ishida, Yasuyuki Araki, Motowo Mizuno

    Journal of Japanese Society of Gastroenterology   107 ( 9 )   1456 - 1465   2010.9

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  • Carbon dioxide insufflation is useful for obtaining clear images of the bile duct during peroral cholangioscopy (with video) Reviewed

    Toru Ueki, Motowo Mizuno, Shigeru Ota, Tsuneyoshi Ogawa, Hiroshi Matsushita, Daisuke Uchida, Norifumi Numata, Asuka Ueda, Yuuki Morimoto, Yoko Kominami, Shintaro Nanba, Manabu Kurome, Hirotoki Ohe, Masahiro Nakagawa, Yasuyuki Araki

    Gastrointestinal Endoscopy   71 ( 6 )   1046 - 1051   2010.5

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    DOI: 10.1016/j.gie.2010.01.015

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  • Outcomes of endoscopic treatment for malignant biliary obstruction in patients with surgically altered anatomy: analysis of risk factors for clinical failure. International journal

    Takeshi Tomoda, Hironari Kato, Kazuya Miyamoto, Akihiro Matsumi, Eijiro Ueta, Yuuki Fujii, Yousuke Saragai, Tatsuhiro Yamazaki, Daisuke Uchida, Kazuyuki Matsumoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hiroyuki Okada

    Surgical endoscopy   35 ( 1 )   232 - 238   2020.1

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    BACKGROUND: To evaluate the outcomes of endoscopic retrograde cholangiopancreatography (ERCP) for malignant biliary obstruction (MBO) using short-type double-balloon enteroscope (sDBE) in patients with surgically altered anatomy. METHODS: A total of 45 patients with surgically altered anatomy underwent ERCP using sDBE for the treatment of MBO between April 2011 and March 2019. We retrospectively evaluated the clinical and technical success (insertion and biliary intervention success), adverse events, and risk factors for clinical failure. RESULTS: The scope was successfully inserted in the target site in 82.2% of patients (37/45), and among them, biliary intervention success was achieved in 86.4% (32/37). The overall technical success rate was 71.1% (32/45) and clinical success rate was 68.9% (31/45), with an adverse event rate of 11.1%. In multivariate analysis, the presence of peritoneal dissemination (odds ratio, 7.3; 95% confidence interval, 1.5-43.5, p = 0.02) was as an independent risk factor for clinical failure. The clinical success rate was 38.5% in patients with peritoneal dissemination and 81.3% in those without peritoneal dissemination. CONCLUSION: Endoscopic treatment using sDBE in patients without peritoneal dissemination provided favorable outcomes, and it can be an initial treatment for MBO in patients with surgically altered anatomy.

    DOI: 10.1007/s00464-020-07385-y

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  • 【胆膵内視鏡トラブルシューティング-こうやって切り抜けろ-】EUS-HGSにおける手技の工夫 ダブルガイドワイヤー法について

    内田 大輔, 加藤 博也, 松三 明宏, 宮本 和也, 山崎 辰洋, 藤井 佑樹, 皿谷 洋祐, 友田 健, 松本 和幸, 堀口 繁, 堤 康一郎, 岡田 裕之

    胆と膵   40 ( 6 )   529 - 533   2019.6

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  • 【消化器ステンティングのすべて】胆膵 良性胆管狭窄における経乳頭的アプローチ

    加藤 博也, 内田 大輔, 友田 健, 松本 和幸, 堀口 繁, 岡田 裕之

    消化器内視鏡   31 ( 5 )   812 - 818   2019.5

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  • Immuno-Oncology時代の消化器がん診療 難治性消化器癌に対するREIC/Dkk-3遺伝子治療

    内田 大輔, 白羽 英則, 岡田 裕之

    日本消化器病学会雑誌   116 ( 臨増総会 )   A113 - A113   2019.3

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  • 膵・胆管合流異常に合併した胆嚢癌術後に膵管内乳頭粘液性腺癌(IPMC)を発生した1例

    池田 愛璃, 松本 和幸, 加藤 博也, 田中 顕之, 赤穂 宗一郎, 室 信一郎, 内田 大輔, 友田 健, 堀口 繁, 岡田 裕之

    日本消化器病学会雑誌   116 ( 3 )   241 - 248   2019.3

  • 【Biliary access大辞典】経乳頭的biliary access カニュレーションテクニック ESTナイフを用いたカニュレーションテクニック

    加藤 博也, 松三 明宏, 石原 裕基, 矢部 峻太郎, 室 信一郎, 内田 大輔, 友田 健, 松本 和幸, 堀口 繁, 岡田 裕之

    胆と膵   39 ( 臨増特大 )   975 - 980   2018.11

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  • 【胆膵ドレナージupdate】[胆道ドレナージ] 肝門部悪性胆道狭窄に対する経乳頭的胆道ドレナージ

    加藤 博也, 矢部 俊太郎, 室 信一郎, 内田 大輔, 友田 健, 松本 和幸, 堀口 繁, 岡田 裕之

    消化器内視鏡   30 ( 11 )   1523 - 1530   2018.11

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  • REIC/Dkk-3遺伝子導入における胆道癌の新規治療法開発

    田中 瑛美, 内田 大輔, 白羽 英則, 加藤 博也, 岡田 裕之

    日本消化器病学会雑誌   115 ( 臨増大会 )   A744 - A744   2018.10

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  • 良性胆道狭窄に対する内視鏡治療の現況

    加藤 博也, 内田 大輔, 友田 健, 松本 和幸, 堀口 繁, 岡田 裕之

    胆道   32 ( 4 )   732 - 742   2018.10

  • 膵癌術後再発に対するEUS-FNAの有用性 洗浄液を用いた遺伝子変異解析も含めて

    松本 和幸, 加藤 博也, 赤穂 宗一郎, 吉田 龍一, 楳田 祐三, 信岡 大輔, 皿谷 洋祐, 高田 斎文, 室 信一郎, 内田 大輔, 友田 健, 堀口 繁, 能祖 一裕, 八木 孝仁, 岡田 裕之

    膵臓   33 ( 3 )   516 - 516   2018.5

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  • "消化管吻合部の縫合線"を利用した、術後再建腸管症例に対するERCPのスコープ挿入手技

    堤 康一郎, 加藤 博也, 堀口 繁, 松本 和幸, 友田 健, 内田 大輔, 秋元 悠, 室 信一郎, 水川 翔, 岡田 裕之

    Gastroenterological Endoscopy   59 ( 8 )   1644 - 1652   2017.8

  • Gender Differences in Clinicopathological Features of 20 Cases With Solid Pseudopapillary Neoplasms of the Pancreas

    Yutaka Akimoto, Hironari Kato, Ryo Harada, Daisuke Uchida, Hiroyuki Seki, Takeshi Tomoda, Kazuyuki Matsumoto, Naoki Yamamoto, Shigeru Horiguchi, Koichiro Tsutsumi, Shin-ichiro Muro, Toru Ueki, Shinsuke Oda, Soichiro Fushimi, Takahito Yagi, Hiroyuki Okada

    PANCREAS   46 ( 6 )   831 - 831   2017.7

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  • 【ERCPのエキスパートを目指して】肝門部マルチステンティングの実際とコツ

    加藤 博也, 室 信一郎, 秋元 悠, 内田 大輔, 友田 健, 松本 和幸, 堀口 繁, 堤 康一郎, 河本 博文, 岡田 裕之

    消化器内視鏡   29 ( 5 )   879 - 884   2017.5

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  • 難治性肝細胞癌に対するREIC/Dkk-3を用いた遺伝子治療

    大山 淳史, 澤原 大明, 内田 大輔, 白羽 英則, 岡田 裕之

    肝臓   58 ( Suppl.1 )   A282 - A282   2017.4

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  • 膵神経内分泌腫瘍における液状化検体細胞診(LBC)を用いた免疫染色の有用性の検討

    秋元悠, 加藤博也, 田中顕之, 井上博文, 皿谷洋祐, 高田斎文, 水川翔, 室信一郎, 内田大輔, 友田健, 松本和幸, 堀口繁, 堤康一郎, 岡田裕之

    膵臓   32 ( 3 )   2017

  • Effectiveness and safety of peroral direct cholangioscopy using an ultraslim endoscope for the treatment of hepatolithiasis in patients with hepaticojejunostomy

    Kazuyuki Matsumoto, Koichiro Tsutsumi, Hironari Kato, Naoki Yamamoto, Shigeru Horiguchi, Yutaka Akimoto, Daisuke Uchida, Takeshi Tomoda, Hiroyuki Okada

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   31   221 - 222   2016.11

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  • 【胆膵内視鏡自由自在〜基本手技を学び応用力をつける集中講座〜】内視鏡システムと内視鏡操作に関する基本知識 術後再建腸管に対するバルーン内視鏡挿入操作の基本と挿入のコツ

    堤 康一郎, 加藤 博也, 水川 翔, 室 信一郎, 秋元 悠, 内田 大輔, 友田 健, 松本 和幸, 山本 直樹, 堀口 繁, 岡田 裕之

    胆と膵   37 ( 臨増特大 )   1137 - 1143   2016.11

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  • 【Interventional EUSのすべて】胆道病変におけるEUS-FNAの実際

    加藤 博也, 松本 和幸, 水川 翔, 秋元 悠, 内田 大輔, 友田 健, 山本 直樹, 堀口 繁, 堤 康一郎, 岡田 裕之

    消化器内視鏡   28 ( 10 )   1607 - 1612   2016.10

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  • Novel REIC/Dkk-3-encoding adenoviral vector as a promising therapeutic agent for pancreatic cancer

    H. Sawahara, H. Shiraha, D. Uchida, H. Kato, T. Nagahara, M. Iwamuro, J. Kataoka, S. Horiguchi, M. Watanabe, M. Sakaguchi, A. Takaki, K. Nouso, Y. Nasu, H. Kumon, H. Okada

    CANCER GENE THERAPY   23 ( 8 )   278 - 283   2016.8

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  • Treatment of Bile Duct Stones in Patients With Prior Hepaticojejunostomy: A Percutaneous Approach Using Cholangioscopy vs. an Endoscopic Approach Using Short Double-Balloon Enteroscopy

    Koichiro Tsutsumi, Hironari Kato, Shuntaro Yabe, Syo Mizukawa, Hiroyuki Seki, Yutaka Akimoto, Daisuke Uchida, Kazuyuki Matsumoto, Takeshi Tomoda, Naoki Yamamoto, Shigeru Horiguchi, Hiroyuki Okada

    GASTROINTESTINAL ENDOSCOPY   83 ( 5 )   AB619 - AB619   2016.5

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  • 胆嚢神経内分泌癌(NEC)の1例

    堀口 繁, 加藤 博也, 内田 大輔, 秋元 悠, 関 博之, 友田 健, 松本 和幸, 山本 直樹, 堤 康一郎, 植木 亨, 岡田 裕之

    胆道   30 ( 2 )   290 - 297   2016.5

  • 膵Solid Pseudopapillary Neoplasm 20例の臨床病理学的特徴 性別による比較

    秋元 悠, 加藤 博也, 原田 亮, 内田 大輔, 關 博之, 友田 健, 松本 和幸, 山本 直樹, 堀口 繁, 堤 康一郎, 室 信一郎, 植木 亨, 小田 晋輔, 伏見 聡一郎, 八木 孝仁, 岡田 裕之

    膵臓   31 ( 2 )   135 - 144   2016.4

  • 【膵疾患の分子病態】網羅的糖鎖解析によるIPMNの悪性度診断能の検討

    秋元 悠, 能祖 一裕, 加藤 博也, 宮原 孝治, 水川 翔, 矢部 俊太郎, 内田 大輔, 關 博之, 友田 健, 松本 和幸, 山本 直樹, 堀口 繁, 堤 康一郎, 岡田 裕之

    膵臓   31 ( 1 )   25 - 31   2016.2

  • Time-dependent image changes after ethanol injection into the pancreas: an experimental study using a porcine model. International journal

    Kazuyuki Matsumoto, Hironari Kato, Koichiro Tsutsumi, Soichiro Fushimi, Masaya Iwamuro, Shinsuke Oda, Sho Mizukawa, Yutaka Akimoto, Daisuke Uchida, Takeshi Tomoda, Naoki Yamamoto, Shigeru Horiguchi, Hiroyuki Okada

    Ecancermedicalscience   10   663 - 663   2016

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    BACKGROUND: Ethanol, a commonly available agent, has been used to successfully ablate cystic and solid lesions in the pancreas. The aim of this study is to investigate the effects of an ethanol injection into the porcine pancreas and observe the time-dependent image changes in the pancreatic parenchyma. METHODS: Pure ethanol was injected into the pancreatic tail using a 25-gauge EUS needle with direct ultrasound guidance under celiotomy: 1 mL and 2 mL were injected, respectively. The abdomen was closed after the injection. MRI was performed before the procedure, immediately after, and on postoperative day (POD) seven. Blood samples were taken before the procedure and on PODs one, three, five, and seven. The pigs were euthanised on POD seven. RESULTS: Immediately after the injection, linear high signal areas in the pancreatic tail on T2 and rounded speckled high signal areas on DWI images were detected in both animals, measuring 35 × 32 mm in the 1 mL injected pig and 42 × 38mm in the 2 mL injected pig. After POD seven, rounded high signal areas were noted on T2 images, measuring 22 × 18 mm and 36 × 28 mm respectively. On POD one, the 1 mL injected animal had a 53% elevation in serum amylase while the 2 mL injected animal had a 66% elevation. Histologically, cystic and necrotic changes in the parenchyma were observed, measuring 23 × 22 mm and 40 × 35 mm respectively. CONCLUSIONS: Our results, which are limited to normal pancreas, suggested that a 1 mL injection caused localised changes within the pancreas while a 2 mL injection induced more widespread changes beyond the pancreas. The effective area of ethanol was widespread immediately after injection, and then the area was reduced with cystic and necrosis changes.

    DOI: 10.3332/ecancer.2016.663

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  • Clinical outcome of endoscopic double stenting for the treatment of malignant biliary and duodenal obstruction due to pancreatic cancer

    Kazuyuki Matsumoto, Hironari Kato, Koichiro Tsutsumi, Sho Mizukawa, Shuntaro Yabe, Yutaka Akimoto, Daisuke Uchida, Hiroyuki Seki, Takeshi Tomoda, Naoki Yamamoto, Shigeru Horiguchi, Hiroyuki Okada

    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY   30   225 - 225   2015.12

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  • エトポシドとシスプラチンの併用療法(EP療法)が著効し組織学的CRが得られた肝原発小細胞癌の1切除例

    秋元 悠, 堤 康一郎, 加藤 博也, 幡 英典, 榮 浩行, 内田 大輔, 友田 健, 松本 和幸, 野間 康宏, 山本 直樹, 堀口 繁, 原田 亮, 岡田 裕之, 柳井 広之, 八木 孝仁, 山本 和秀

    日本消化器病学会雑誌   112 ( 11 )   2024 - 2034   2015.11

  • FOLFIRINOX with modified regimen therapy for advanced pancreatic cancer in Okayama university hospital

    Shigeru Horiguchi, Hironari Kato, Yutaka Akimoto, Daisuke Uchida, Takeshi Tomoda, Kazuyuki Matsumoto, Naoki Yamamoto, Koichiro Tsutsumi, Junichiro Nasu, Kazuhide Yamamoto

    ANNALS OF ONCOLOGY   26   119 - 120   2015.11

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  • Serum oxidative-anti-oxidative stress balance is dysregulated in patients with non-alcoholic steatohepatitis and related hepatocellular carcinoma

    Yasuyuki Shimomura, Akinobu Takaki, Nozomu Wada, Daisuke Uchida, Yasuto Takeuchi, Tetsuya Yasunaka, Fusao Ikeda, Hideki Onishi, Kenji Kuwaki, Shinichiro Nakamura, Kazuhiro Nouso, Yasuhiro Miyake, Kazuko Koike

    HEPATOLOGY   62   1297A - 1297A   2015.10

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  • 【ERCPマスターへのロードマップ】トラブルシューティング編 膵管プラスチックステント迷入に対する内視鏡的回収法

    松本 和幸, 加藤 博也, 堤 康一郎, 水川 翔, 矢部 俊太郎, 内田 大輔, 秋元 悠, 關 博之, 友田 健, 山本 直樹, 堀口 繁, 岡田 裕之

    胆と膵   36 ( 臨増特大 )   1081 - 1086   2015.10

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  • 【EUS下胆道ドレナージ〜EUS-BDの安全な導入へ向けて〜】EUS-BDにおける使用デバイスの選択 超音波内視鏡、穿刺針、ガイドワイヤー、ダイレーター

    加藤 博也, 水川 翔, 矢部 俊太郎, 秋元 悠, 内田 大輔, 關 博之, 友田 健, 松本 和幸, 山本 直樹, 堀口 繁, 堤 康一郎, 岡田 裕之

    胆と膵   36 ( 8 )   751 - 756   2015.8

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  • Efficacy and Safety of Endoscopic Treatment of Hepatolithiasis Using a Short Double-Balloon Enteroscope in Patients With Prior Hepaticojejunostomy

    Koichiro Tsutsumi, Hironari Kato, Daisuke Uchida, Yutaka Akimoto, Kazuyuki Matsumoto, Takeshi Tomoda, Yasuhiro Noma, Naoki Yamamoto, Sigeru Horiguchi, Hiroyuki Okada, Kazuhide Yamamoto

    GASTROINTESTINAL ENDOSCOPY   81 ( 5 )   AB361 - AB361   2015.5

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  • Oxidative Stress Balance Is Dysregulated in Cholangiocarcinoma That Could Be Improved With L-Carnitine Administration

    Daisuke Uchida, Akinobu Takaki, Yasuko Tomono, Kazuhide Yamamoto

    GASTROENTEROLOGY   148 ( 4 )   S967 - S967   2015.4

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  • Adenovirus-Mediated Overexpression of REIC/DKK-3 Inhibits Cell Growth and Induces Apoptosis in Pancreatic Cancer and Hepatocellular Carcinoma

    Sawahara Hiroaki, Hidenori Shiraha, Daisuke Uchida, Hironari Kato, Masami Watanabe, Hiromi Kumon, Yasutomo Nasu, Kazuhide Yamamoto

    GASTROENTEROLOGY   148 ( 4 )   S954 - S954   2015.4

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  • REIC/Dkk-3遺伝子導入による肝細胞癌治療の検討

    澤原 大明, 内田 大輔, 白羽 英則, 永原 照也, 岩室 雅也, 片岡 淳朗, 堀口 繁, 竹内 康人, 桑木 健志, 大西 秀樹, 中村 進一郎, 高木 章乃夫, 能祖 一裕, 山本 和秀

    日本消化器病学会雑誌   112 ( 臨増総会 )   A345 - A345   2015.3

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  • 膵/胆道癌の分子標的・免疫と治療応用 REIC/Dkk-3遺伝子による膵癌治療

    内田 大輔, 白羽 英則, 山本 和秀

    日本消化器病学会雑誌   111 ( 臨増大会 )   A702 - A702   2014.9

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  • γ-secretase inhibitorによるNotch経路阻害は膵癌幹細胞を阻害し抗癌剤治療効果を増強する可能性がある

    堀口 繁, 白羽 英則, 内田 大輔, 永原 照也, 片岡 淳朗, 岩室 雅也, 加藤 博也, 高木 章乃夫, 能祖 一裕, 山本 和秀

    日本消化器病学会雑誌   111 ( 臨増大会 )   A951 - A951   2014.9

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  • 膵癌におけるγセクレターゼ阻害剤を用いた幹細胞抑制による抗癌剤増強効果の検討

    堀口 繁, 白羽 英則, 内田 大輔, 永原 照也, 片岡 淳朗, 岩室 雅也, 加藤 博也, 高木 章乃夫, 能祖 一裕, 山本 和秀

    膵臓   29 ( 3 )   553 - 553   2014.6

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  • The Efficacy of REIC/DKK-3 Gene Therapy for Pancreatic Cancer

    Daisuke Uchida, Hidenori Shiraha, Hironari Kato, Teruya Nagahara, Masaya Iwamuro, Junro Kataoka, Sigeru Horiguchi, Masami Watanabe, Yasutomo Nasu, Hiromi Kumon, Kazuhide Yamamoto

    GASTROENTEROLOGY   146 ( 5 )   S301 - S301   2014.5

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  • 肝癌におけるNotchシグナル活性化とその治療ターゲットとしての可能性

    白羽 英則, 片岡 淳朗, 堀口 繁, 岩室 雅也, 永原 照也, 内田 大輔, 仁科 慎一, 竹内 康人, 桑木 健志, 大西 秀樹, 中村 進一郎, 高木 章乃夫, 能祖 一裕, 山本 和秀

    肝臓   55 ( Suppl.1 )   A229 - A229   2014.4

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  • γセクレターゼ阻害剤を用いた膵癌幹細胞治療についての検討

    堀口 繁, 白羽 英則, 内田 大輔, 永原 照也, 岩室 雅也, 片岡 淳朗, 加藤 博也, 高木 章乃夫, 能祖 一裕, 山本 和秀

    日本消化器病学会雑誌   111 ( 臨増総会 )   A289 - A289   2014.3

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  • 肝細胞癌は、肝星細胞と液性因子を介したインテラクションにより幹細胞化が進行する

    永原 照也, 白羽 英則, 内田 大輔, 岩室 雅也, 片岡 淳朗, 堀口 繁, 山本 和秀

    日本消化器病学会雑誌   111 ( 臨増総会 )   A273 - A273   2014.3

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  • REIC/Dkk-3遺伝子導入による膵癌治療の検討

    内田 大輔, 白羽 英則, 加藤 博也, 永原 照也, 岩室 雅也, 片岡 淳郎, 堀口 繁, 堤 康一郎, 那須 保友, 公文 裕巳, 山本 和秀

    膵臓   28 ( 3 )   371 - 371   2013.6

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  • 肝癌におけるRUNX3発現低下はNotchシグナルを介し癌幹細胞化とEMTを制御する

    白羽 英則, 片岡 淳朗, 堀口 繁, 岩室 雅也, 永原 照也, 内田 大輔, 仁科 慎一, 高木 章乃夫, 萩原 宏明, 桑木 健志, 大西 秀樹, 中村 進一郎, 能祖 一裕, 山本 和秀

    肝臓   54 ( Suppl.1 )   A151 - A151   2013.4

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  • RUNX3欠失はmultidrug resistant protein発現を介してgemcitabine感受性に影響を与える

    堀口 繁, 白羽 英則, 内田 大輔, 永原 照也, 片岡 淳朗, 岩室 雅也, 松原 稔, 加藤 博也, 高木 章乃夫, 能祖 一裕, 八木 孝仁, 山本 和秀

    日本消化器病学会雑誌   110 ( 臨増総会 )   A210 - A210   2013.2

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  • 肝癌EMTマーカーとしてのPIVKA-II

    白羽 英則, 堀口 繁, 岩室 雅也, 片岡 淳朗, 永原 照也, 内田 大輔, 高木 章乃夫, 萩原 宏明, 桑木 健志, 大西 秀樹, 中村 進一郎, 能祖 一裕, 山本 和秀

    日本消化器病学会雑誌   110 ( 臨増総会 )   A387 - A387   2013.2

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  • 膵癌において、CD44の発現は、RUNX3発現は逆相関する(CD44 expression correlates negatively with runt-related transcription factor 3 in pancreatic ductal adenocarcinoma)

    堀口 繁, 白羽 英則, 内田 大輔, 永原 照也, 岩室 雅也, 片岡 淳朗, 加藤 博也, 高木 章乃夫, 能祖 一裕, 山本 和秀

    日本癌学会総会記事   71回   179 - 180   2012.8

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  • 肝細胞癌において、カルボキシラーゼ活性低下はEMT進行に寄与する(Deactivation of GGCX induced epithelial-mesenchymal transition in hepatocellular carcinoma)

    白羽 英則, 片岡 淳朗, 中村 進一郎, 能祖 一裕, 堀口 繁, 岩室 雅也, 永原 照也, 松原 稔, 内田 大輔, 桑木 健志, 萩原 宏明, 大西 秀樹, 山本 和秀

    日本癌学会総会記事   71回   142 - 142   2012.8

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  • 肝細胞癌において、MRP発現とEMT進行は相関する(MRP expression correlates with epithelial-mesenchymal transition progression in hepatocellular carcinoma)

    片岡 淳朗, 白羽 英則, 中村 進一郎, 能祖 一裕, 堀口 繁, 岩室 雅也, 永原 照也, 松原 稔, 内田 大輔, 桑木 健志, 萩原 宏明, 大西 秀樹, 山本 和秀

    日本癌学会総会記事   71回   144 - 144   2012.8

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Awards

  • PanCAN Young Investigator Award

    2013.7   日本膵臓学会  

    内田 大輔

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Research Projects

  • Development of Innovative Endoscopic Minimally Invasive Treatment for Small and Low-Grade Malignant Pancreatic Neuroendocrine Tumors

    Grant number:24K11111  2024.04 - 2027.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    松本 和幸, 内田 大輔, 加藤 博也, 竹内 康人

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    Grant amount:\4550000 ( Direct expense: \3500000 、 Indirect expense:\1050000 )

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  • 膵神経内分泌腫瘍に対する治癒率向上と膵機能温存を目指した内視鏡的低侵襲治療法の開発

    Grant number:23ck0106900h0001  2023.10 - 2026.03

    国立研究開発法人日本医療研究開発機構(AMED)  革新的がん医療実用化研究事業 

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    Authorship:Coinvestigator(s) 

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  • 超音波内視鏡診断支援プログラムの社会実装に向けた基盤整備

    Grant number:23K11932  2023.04 - 2026.03

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    内田 大輔

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    Grant amount:\4680000 ( Direct expense: \3600000 、 Indirect expense:\1080000 )

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  • 消化器がん幹細胞標的療法としての遺伝子治療開発

    Grant number:23K07438  2023.04 - 2026.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    白羽 英則, 岩室 雅也, 大西 秀樹, 堀口 繁, 内田 大輔, 竹内 康人

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    Grant amount:\4550000 ( Direct expense: \3500000 、 Indirect expense:\1050000 )

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  • 胆膵癌に対する抗PD-1モノクローナル抗体併用REIC遺伝子治療

    2019.04 - 2022.03

    日本学術振興会  科学研究費補助金 若手研究 

    内田 大輔

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    Authorship:Principal investigator  Grant type:Competitive

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  • 抗癌剤耐性胆膵癌における耐性獲得機序の解明とREIC遺伝子治療の有効性の検討

    2017.04 - 2019.03

    日本学術振興会  科学研究費補助金 若手研究(B) 

    内田 大輔

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  • 消化器癌における新規癌関連遺伝子REICの機能解析と臨床応用に関する研究

    2015.04 - 2017.03

    日本学術振興会  科学研究費補助金 基盤研究(C) 

    加藤 博也

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    Grant type:Competitive

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