研究者詳細 - 寳田　剛志

MISC - 寳田　剛志

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虚血性神経細胞障害におけるアミノ酸トランスポーターSlc38a1の役割

中村早希, 宝田剛志, 國保博史, 金田勝幸, 米田幸雄

日本薬学会北陸支部総会及び例会プログラム・講演要旨集 127th 33 2015年

虚血性神経細胞障害におけるグルタミントランスポーターSlc38a1の役割

中村早希, 宝田剛志, 國保博史, 金田勝幸, 米田幸雄

日本薬理学会近畿部会プログラム・要旨集 128th 42 2015年

PROLIFERATION AND DIFFERENTIATION OF NEURAL PROGENITORS EXPOSED TO NICOTINE

R. Nakazato, T. Takarada, Y. Yoneda

ALCOHOL AND ALCOHOLISM 49 2014年9月

The role of uncoupling protein-2 in glutamate neurotoxicity with ischemia

Ryo Fukumori, Takeshi Takarada, Yukio Yoneda

JOURNAL OF PHARMACOLOGICAL SCIENCES 124 180P - 180P 2014年

A role of the osteoblastic master regulator, runt-related transcription factor-2, in microglial cells

Ryota Nakazato, Takeshi Takarada, Yukio Yoneda

JOURNAL OF PHARMACOLOGICAL SCIENCES 124 124P - 124P 2014年

Analysis of signaling cascade of transcription factors in joint tissue toward drug discovery

Takeshi Takarada

JOURNAL OF PHARMACOLOGICAL SCIENCES 124 16P - 16P 2014年

Neuropsychiatric systemic lupus erythematosus: Pathophysiology and the future of treatment

Takahisa Gono, Takeshi Takarada, Yasuhiro Katsumata, Yasushi Kawaguchi, Yukio Yoneda, Hisashi Yamanaka

International Journal of Clinical Rheumatology 8 ( 5 ) 585 - 595 2013年10月

記述言語：英語掲載種別：書評論文，書評，文献紹介等

Systemic lupus erythematosus (SLE) is characterized by the presence of several autoantibodies, including anti-dsDNA. Among types of SLE, neuropsychiatric (NP)-SLE accounts for significant morbidity and mortality. Cerebrovascular disease, which could account for most of the serious permanent neurological damage, is a common presentation of NP-SLE. The pathophysiology of NP-SLE involves several factors, including vasculitis, thrombosis, and inflammation and/or apoptosis of neuronal and glial cells. The current treatment strategy is immunosuppressive therapy, which is occasionally insufficient for patients with NP-SLE. Recent studies have revealed that autoantibodies, such as anti-NR2, pass from the peripheral blood to the brain through the blood-brain barrier, cross-react with human brain tissue and cause increased intracellular Ca2+ in SLE. Regulating blood-brain barrier permeability, inhibiting autoantibody deposition in tissues and modulating intracellular Ca2+ may be new concepts for the treatment with NP-SLE. © 2013 Future Medicine Ltd.

DOI： 10.2217/ijr.13.48

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Mitochondrial uncoupling protein-2 in glutamate neurotoxicity

Takeshi Takarada, Ryo Fukumori, Yukio Yoneda

JOURNAL OF PHARMACOLOGICAL SCIENCES 121 21P - 21P 2013年

A role of the glutamine transporter slc38a1 in brain

H. Kokubo, T. Takarada, K. Fujikawa, R. Fukumori, R. Nakazato, Y. Kim, Y. Yoneda

JOURNAL OF NEUROCHEMISTRY 123 128 - 128 2012年10月

A role of the osteoblastic master regulator, runt-related factor 2 (Runx2), in astrocytes

T. Takarada, K. Fujikawa, Y. Yoneda

JOURNAL OF NEUROCHEMISTRY 123 35 - 35 2012年10月

Clock genes expressed by microglia

S. Hotta, T. Takarada, L. Q. Nguyen, S. Shimba, Y. Yoneda

JOURNAL OF NEUROCHEMISTRY 123 90 - 91 2012年10月

ATP-induced delay of mitochondrial membrane potential disruption by NMDA in cultured rat hippocampal neurons

K. Fujikawa, N. Nakamichi, R. Fukumori, T. Takarada, Y. Yoneda

JOURNAL OF NEUROCHEMISTRY 123 83 - 83 2012年10月

Runt related transcription factor-2 expression by microglial cells

R. Nakazato, T. Takarada, Y. Yoneda

JOURNAL OF NEUROCHEMISTRY 123 91 - 91 2012年10月

Neuronal differentiation promotion mediated by nicotinic acetylcholine receptors expressed by neural progenitors

Y. -H. Kim, T. Takarada, S. Kitajima, R. Fukumori, R. Nakazato, K. Fujikawa, M. Kou, Y. Yoneda

JOURNAL OF NEUROCHEMISTRY 123 109 - 109 2012年10月

A role of mitochondrial uncoupling protein-2 in NMDA neurotoxicity

R. Fukumori, T. Takarada, Y. Yoneda

JOURNAL OF NEUROCHEMISTRY 123 83 - 83 2012年10月

An astrocytic phenotype in Bmal1-null mice

L. Q. Nguyen, T. Takarada, B. T. Nguyen, R. Fukumori, R. Nakazato, K. Fujikawa, S. Hotta, M. Kou, S. Shimba, Y. Yoneda

JOURNAL OF NEUROCHEMISTRY 123 92 - 93 2012年10月

Upregulation of Ifrd1 expression in brains of mice with middle cerebral artery occlusion

M. Kou, T. Takarada, R. Fukumori, R. Nakazato, M. Hida, Y. Yoneda

JOURNAL OF NEUROCHEMISTRY 123 62 - 62 2012年10月

Functional analysis of the glutamine transporter slc38a1 in brain

Aya Sako, Takeshi Takarada, Yukio Yoneda

JOURNAL OF PHARMACOLOGICAL SCIENCES 118 119P - 119P 2012年

Upregulation of Runx2 expression by ATP in microglial cells

Ryota Nakazato, Takeshi Takarada, Yukio Yoneda

JOURNAL OF PHARMACOLOGICAL SCIENCES 118 100P - 100P 2012年

Functional analysis of dock genes expressed in microglia

Shogo Hotta, Takeshi Takarada, Shigeki Shimba, Yukio Yoneda

JOURNAL OF PHARMACOLOGICAL SCIENCES 118 100P - 100P 2012年

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