論文 - 大塚 基之
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Direct differentiation of hepatic cells from human induced pluripotent stem cells using a limited number of cytokines 査読
Akemi Takata, Motoyuki Otsuka, Tomomi Kogiso, Kentaro Kojima, Takeshi Yoshikawa, Ryosuke Tateishi, Naoya Kato, Shuichiro Shiina, Haruhiko Yoshida, Masao Omata, Kazuhiko Koike
HEPATOLOGY INTERNATIONAL 5 ( 4 ) 890 - 898 2011年12月
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Receptor for Activated Protein Kinase C: Requirement for Efficient MicroRNA Function and Reduced Expression in Hepatocellular Carcinoma 査読
Motoyuki Otsuka, Akemi Takata, Takeshi Yoshikawa, Kentaro Kojima, Takahiro Kishikawa, Chikako Shibata, Mutsuhiro Takekawa, Haruhiko Yoshida, Masao Omata, Kazuhiko Koike
PLOS ONE 6 ( 9 ) 2011年9月
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MicroRNA-22 and microRNA-140 suppress NF-κB activity by regulating the expression of NF-κB coactivators. 査読
Takata A, Otsuka M, Kojima K, Yoshikawa T, Kishikawa T, Yoshida H, Koike K
Biochemical and biophysical research communications 411 ( 4 ) 826 - 831 2011年8月
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HCV関連肝細胞癌患者の高齢化と非硬変肝からの発癌の増加
吉田 晴彦, 建石 良介, 佐藤 雅哉, 三神 信太郎, 内野 康史, 新野 徹, 榎奥 健一郎, 後藤 絵里子, 中川 隼人, 増崎 良太, 浅岡 良成, 大塚 基之, 山敷 宣代, 五藤 忠, 椎名 秀一朗, 小俣 政男, 小池 和彦
肝臓 52 ( Suppl.1 ) A411 - A411 2011年4月
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Reduced expression of RAS protein activator like-1 in gastric cancer 査読
Motoko Seto, Miki Ohta, Tsuneo Ikenoue, Takafumi Sugimoto, Yoshinari Asaoka, Motohisa Tada, Dai Mohri, Yotaro Kudo, Hideaki Ijichi, Keisuke Tateishi, Motoyuki Otsuka, Yoshihiro Hirata, Shin Maeda, Kazuhiko Koike, Masao Omata
INTERNATIONAL JOURNAL OF CANCER 128 ( 6 ) 1293 - 1302 2011年3月
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Epithelial p38 alpha Controls Immune Cell Recruitment in the Colonic Mucosa 査読
Young Jun Kang, Motoyuki Otsuka, Arjen van den Berg, Lixin Hong, Zhe Huang, Xiurong Wu, Duan-Wu Zhang, Bruce A. Vallance, Peter S. Tobias, Jiahuai Han
PLOS PATHOGENS 6 ( 6 ) e1000934 2010年6月
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DDX20 deficiency enhances NF-kappa B by impairing NF-kappa B suppressive-microRNA function and leads to hepatocarcinogenesis 査読
Takata Akemi, Otsuka Motoyuki, Kudo Yotaro, Kojima Kentaro, Maeda Shin, Tateishi Keisuke, Ikenoue Tsuneo, Ijichi Hideaki, Hirata Yoshihiro, Yoshida Haruhiko, Omata Masao, Koike Kazuhiko
CANCER RESEARCH 70 2010年4月
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Apoptosis Signal-Regulating Kinase 1 Regulates Colitis and Colitis-Associated Tumorigenesis by the Innate Immune Responses 査読
Yoku Hayakawa, Yoshihiro Hirata, Hayato Nakagawa, Kei Sakamoto, Yohko Hikiba, Motoyuki Otsuka, Hideaki Ijichi, Tsuneo Ikenoue, Keisuke Tateishi, Masao Akanuma, Keiji Ogura, Haruhiko Yoshida, Hidenori Ichijo, Masao Omata, Shin Maeda
GASTROENTEROLOGY 138 ( 3 ) 1055 - U334 2010年3月
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TNF-alpha stimulation inhibits siRNA-mediated RNA interference through a mechanism involving poly-(A) tail stabilization. 査読
Mols J, van den Berg A, Otsuka M, Zheng M, Chen J, Han J
Biochimica et biophysica acta 1779 712 - 719 2008年11月
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TNF-alpha stimulation inhibits siRNA-mediated RNA interference through a mechanism involving poly-(A) tail stabilization 査読
Johann Mols, Arjen van den Berg, Motoyuki Otsuka, Min Zheng, Jianming Chen, Jiahuai Han
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1779 ( 11 ) 712 - 719 2008年11月
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Potential contribution of tumor suppressor p53 in the host defense against hepatitis C virus 査読
Narayan Dharel, Naoya Kato, Ryosuke Muroyama, Hiroyoshi Taniguchi, Motoyuki Otsuka, Yue Wang, Amarsanaa Jazag, Run-Xuan Shao, Jin-Hai Chang, Mark K. Adler, Takao Kawabe, Masao Omata
HEPATOLOGY 47 ( 4 ) 1136 - 1149 2008年4月
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Macrophage deletion of p38 alpha partially impairs lipopolysaccharide-induced cellular activation 査読
Young Jun Kang, Jianming Chen, Motoyuki Otsuka, Johann Mols, Shuxun Ren, Yinbin Wang, Jiahuai Han
JOURNAL OF IMMUNOLOGY 180 ( 7 ) 5075 - 5082 2008年4月
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Calcineurin negatively regulates TLR-Mediated activation pathways 査読
Young Jun Kang, Brenda Kusler, Motoyuki Otsuka, Michael Hughes, Nobutaka Suzuki, Shinobu Suzuki, Wen-Chen Yeh, Shizuo Akira, Jiahuai Han, Patricia P. Jones
JOURNAL OF IMMUNOLOGY 179 ( 7 ) 4598 - 4607 2007年10月
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Interferon-beta is activated by hepatitis C virus NS5B and inhibited by NS4A, NS4B, and NS5A 査読
Masaru Moriyama, Naoya Kato, Motoyuki Otsuka, Run-Xuan Shao, Hiroyoshi Taniguchi, Takao Kawabe, Masao Omata
HEPATOLOGY INTERNATIONAL 1 ( 2 ) 302 - 310 2007年6月
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Gene expressions associated with chemosensitivity in human hepatoma cells 査読
Yujin Hoshida, Masaru Moriyama, Motoyuki Otsuka, Naoya Kato, Hiroyoshi Taniguchi, Yasushi Shiratori, Naohiko Seki, Masao Omata
HEPATO-GASTROENTEROLOGY 54 ( 74 ) 489 - 492 2007年3月
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Absence of tyrosine kinase mutations in Japanese colorectal cancer patients 査読
R-X Shao, N. Kato, L-J Lin, R. Muroyama, M. Moriyama, T. Ikenoue, H. Watabe, M. Otsuka, B. Guleng, M. Ohta, Y. Tanaka, S. Kondo, N. Dharel, J-H Chang, H. Yoshida, T. Kawabe, M. Omata
ONCOGENE 26 ( 14 ) 2133 - 2135 2007年3月
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Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma 査読
Ryosuke Muroyama, Naoya Kato, Haruhiko Yoshida, Motoyuki Otsuka, Masaru Moriyama, Yue Wang, Run-Xuan Shao, Narayan Dharel, Yasuo Tanaka, Miki Ohta, Ryosuke Tateishi, Shuichiro Shiina, Masashi Tatsukawa, Kenichi Fukai, Fumio Imazeki, Osamu Yokosuka, Yasushi Shiratori, Masao Omata
JOURNAL OF HEPATOLOGY 45 ( 6 ) 805 - 812 2006年12月
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Hepatitis C virus core protein is a potent inhibitor of RNA silencing-based antiviral response 査読
Y Wang, N Kato, A Jazag, N Dharel, M Otsuka, H Taniguchi, T Kawabe, M Omata
GASTROENTEROLOGY 130 ( 3 ) 883 - 892 2006年3月
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Identifying genes with differential expression in gemcitabine-resistant pancreatic cancer cells using comprehensive transcriptome analysis 査読
Y Nakai, M Otsuka, Y Hoshida, M Tada, Y Komatsu, T Kawabe, M Omata
ONCOLOGY REPORTS 14 ( 5 ) 1263 - 1267 2005年11月
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Large-scale search of single nucleotide polymorphisms for hepatocellular carcinoma susceptibility genes in patients with hepatitis C 査読
N Kato, GJ Ji, Y Wang, M Baba, Y Hoshida, M Otsuka, H Taniguchi, M Moriyama, N Dharel, T Goto, RX Shao, T Matsuura, K Ishii, S Shiina, T Kawabe, M Muramatsu, M Omata
HEPATOLOGY 42 ( 4 ) 846 - 853 2005年10月