研究者詳細 - 大塚　基之

論文 - 大塚　基之

分割表示 323 件中 261 - 280 件目／全件表示 >>

A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region 査読国際誌

Urabe Y, Ochi H, Kato N, Kumar V, Takahashi A, Muroyama R, Hosono N, Otsuka M, Tateishi R, Lo P. H, Tanikawa C, Omata M, Koike K, Miki D, Abe H, Kamatani N, Toyota J, Kumada H, Kubo M, Chayama K, Nakamura Y, Matsuda K

J Hepatol 58 ( 5 ) 875 - 82 2013年

Role of interleukin-32 in Helicobacter pylori-induced gastric inflammation.

Sakitani K, Hirata Y, Hayakawa Y, Serizawa T, Nakata W, Takahashi R, Kinoshita H, Sakamoto K, Nakagawa H, Akanuma M, Yoshida H, Maeda S, Koike K

2012年11月

Silencing of microRNA-122 enhances interferon-α signaling in the liver through regulating SOCS3 promoter methylation. 査読

Yoshikawa T, Takata A, Otsuka M, Kishikawa T, Kojima K, Yoshida H, Koike K

Scientific reports 2 637 2012年9月

A miRNA machinery component DDX20 controls NF-κB via microRNA-140 function. 査読

Takata A, Otsuka M, Yoshikawa T, Kishikawa T, Kudo Y, Goto T, Yoshida H, Koike K

Biochemical and biophysical research communications 420 ( 3 ) 564 - 569 2012年4月

Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway 査読

Yotaro Kudo, Yasuo Tanaka, Keisuke Tateishi, Keisuke Yamamoto, Shinzo Yamamoto, Dai Mohri, Yoshihiro Isomura, Motoko Seto, Hayato Nakagawa, Yoshinari Asaoka, Motohisa Tada, Miki Ohta, Hideaki Ijichi, Yoshihiro Hirata, Motoyuki Otsuka, Tsuneo Ikenoue, Shin Maeda, Shuichiro Shiina, Haruhiko Yoshida, Osamu Nakajima, Fumihiko Kanai, Masao Omata, Kazuhiko Koike

JOURNAL OF HEPATOLOGY 55 ( 6 ) 1400 - 1408 2011年12月

Direct differentiation of hepatic cells from human induced pluripotent stem cells using a limited number of cytokines 査読

Akemi Takata, Motoyuki Otsuka, Tomomi Kogiso, Kentaro Kojima, Takeshi Yoshikawa, Ryosuke Tateishi, Naoya Kato, Shuichiro Shiina, Haruhiko Yoshida, Masao Omata, Kazuhiko Koike

HEPATOLOGY INTERNATIONAL 5 ( 4 ) 890 - 898 2011年12月

Receptor for Activated Protein Kinase C: Requirement for Efficient MicroRNA Function and Reduced Expression in Hepatocellular Carcinoma 査読

Motoyuki Otsuka, Akemi Takata, Takeshi Yoshikawa, Kentaro Kojima, Takahiro Kishikawa, Chikako Shibata, Mutsuhiro Takekawa, Haruhiko Yoshida, Masao Omata, Kazuhiko Koike

PLOS ONE 6 ( 9 ) 2011年9月

MicroRNA-22 and microRNA-140 suppress NF-κB activity by regulating the expression of NF-κB coactivators. 査読

Takata A, Otsuka M, Kojima K, Yoshikawa T, Kishikawa T, Yoshida H, Koike K

Biochemical and biophysical research communications 411 ( 4 ) 826 - 831 2011年8月

HCV関連肝細胞癌患者の高齢化と非硬変肝からの発癌の増加

吉田晴彦, 建石良介, 佐藤雅哉, 三神信太郎, 内野康史, 新野徹, 榎奥健一郎, 後藤絵里子, 中川隼人, 増崎良太, 浅岡良成, 大塚基之, 山敷宣代, 五藤忠, 椎名秀一朗, 小俣政男, 小池和彦

肝臓 52 ( Suppl.1 ) A411 - A411 2011年4月

Reduced expression of RAS protein activator like-1 in gastric cancer 査読

Motoko Seto, Miki Ohta, Tsuneo Ikenoue, Takafumi Sugimoto, Yoshinari Asaoka, Motohisa Tada, Dai Mohri, Yotaro Kudo, Hideaki Ijichi, Keisuke Tateishi, Motoyuki Otsuka, Yoshihiro Hirata, Shin Maeda, Kazuhiko Koike, Masao Omata

INTERNATIONAL JOURNAL OF CANCER 128 ( 6 ) 1293 - 1302 2011年3月

Epithelial p38 alpha Controls Immune Cell Recruitment in the Colonic Mucosa 査読

Young Jun Kang, Motoyuki Otsuka, Arjen van den Berg, Lixin Hong, Zhe Huang, Xiurong Wu, Duan-Wu Zhang, Bruce A. Vallance, Peter S. Tobias, Jiahuai Han

PLOS PATHOGENS 6 ( 6 ) e1000934 2010年6月

DDX20 deficiency enhances NF-kappa B by impairing NF-kappa B suppressive-microRNA function and leads to hepatocarcinogenesis 査読

Takata Akemi, Otsuka Motoyuki, Kudo Yotaro, Kojima Kentaro, Maeda Shin, Tateishi Keisuke, Ikenoue Tsuneo, Ijichi Hideaki, Hirata Yoshihiro, Yoshida Haruhiko, Omata Masao, Koike Kazuhiko

CANCER RESEARCH 70 2010年4月

Apoptosis Signal-Regulating Kinase 1 Regulates Colitis and Colitis-Associated Tumorigenesis by the Innate Immune Responses 査読

Yoku Hayakawa, Yoshihiro Hirata, Hayato Nakagawa, Kei Sakamoto, Yohko Hikiba, Motoyuki Otsuka, Hideaki Ijichi, Tsuneo Ikenoue, Keisuke Tateishi, Masao Akanuma, Keiji Ogura, Haruhiko Yoshida, Hidenori Ichijo, Masao Omata, Shin Maeda

GASTROENTEROLOGY 138 ( 3 ) 1055 - U334 2010年3月

TNF-alpha stimulation inhibits siRNA-mediated RNA interference through a mechanism involving poly-(A) tail stabilization 査読

Johann Mols, Arjen van den Berg, Motoyuki Otsuka, Min Zheng, Jianming Chen, Jiahuai Han

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1779 ( 11 ) 712 - 719 2008年11月

TNF-alpha stimulation inhibits siRNA-mediated RNA interference through a mechanism involving poly-(A) tail stabilization. 査読

Motoyuki Otsuka

Biochimica et biophysica acta 1779 712 - 719 2008年4月

掲載種別：研究論文（学術雑誌）出版者・発行元：11

The control of mRNA stability is a complex biological process that involves numerous factors, including microRNA (miRNA) and short interfering RNA (siRNA). Here, we show that short interfering RNA (siRNA) and microRNA share some similarities in their response to cellular stress. miR16 expedites the degradation of mRNAs containing AU-rich elements (ARE) in their 3' untranslated region (UTR). si20 is an siRNA designed to target a non-ARE sequence in the TNF 3'UTR. We found that both si20 and miR16/ARE-mediated degradation of mRNAs can be inhibited by stimulating cells with different stresses. By analyzing TNF-alpha stimulation-mediated stabilization of si20- and miR16-targeted mRNA, we show that this stabilization is not caused by modifying si20 and miR16 loading into Ago2 complexes, or mRNA targeting to Ago2, but by inhibiting mRNA deadenylation. This is the first report showing that a specific siRNA-mediated mRNA degradation can be regulated by inflammatory stimuli, and that deadenylation is involved in this siRNA-mediated mRNA decay.

DOI： 10.1016/j.bbagrm.2008.03.007

PubMed

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Macrophage deletion of p38 alpha partially impairs lipopolysaccharide-induced cellular activation 査読

Young Jun Kang, Jianming Chen, Motoyuki Otsuka, Johann Mols, Shuxun Ren, Yinbin Wang, Jiahuai Han

JOURNAL OF IMMUNOLOGY 180 ( 7 ) 5075 - 5082 2008年4月

Potential contribution of tumor suppressor p53 in the host defense against hepatitis C virus 査読

Narayan Dharel, Naoya Kato, Ryosuke Muroyama, Hiroyoshi Taniguchi, Motoyuki Otsuka, Yue Wang, Amarsanaa Jazag, Run-Xuan Shao, Jin-Hai Chang, Mark K. Adler, Takao Kawabe, Masao Omata

HEPATOLOGY 47 ( 4 ) 1136 - 1149 2008年4月

Calcineurin negatively regulates TLR-Mediated activation pathways 査読

Young Jun Kang, Brenda Kusler, Motoyuki Otsuka, Michael Hughes, Nobutaka Suzuki, Shinobu Suzuki, Wen-Chen Yeh, Shizuo Akira, Jiahuai Han, Patricia P. Jones

JOURNAL OF IMMUNOLOGY 179 ( 7 ) 4598 - 4607 2007年10月

Interferon-beta is activated by hepatitis C virus NS5B and inhibited by NS4A, NS4B, and NS5A 査読

Masaru Moriyama, Naoya Kato, Motoyuki Otsuka, Run-Xuan Shao, Hiroyoshi Taniguchi, Takao Kawabe, Masao Omata

HEPATOLOGY INTERNATIONAL 1 ( 2 ) 302 - 310 2007年6月

Gene expressions associated with chemosensitivity in human hepatoma cells 査読

Yujin Hoshida, Masaru Moriyama, Motoyuki Otsuka, Naoya Kato, Hiroyoshi Taniguchi, Yasushi Shiratori, Naohiko Seki, Masao Omata

HEPATO-GASTROENTEROLOGY 54 ( 74 ) 489 - 492 2007年3月

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