2024/11/15 更新

写真a

タナカ ケイコ
田中 景子
TANAKA KEIKO
所属
医歯薬学域 助教
職名
助教
外部リンク

学位

  • 医学博士 ( 岡山大学 )

研究キーワード

  • 腎臓

研究分野

  • ライフサイエンス / 腎臓内科学

学歴

  • 岡山大学   Graduate School of Medicine , Dentistry and Pharmaceutical Sciences  

    2013年4月 - 2017年6月

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  • 岡山大学   Medical School   Faculty of Medicine

    2002年4月 - 2008年3月

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経歴

  • 岡山大学病院   腎臓・糖尿病・内分泌内科   助教

    2022年1月 - 現在

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  • 岡山大学大学院 医歯薬学総合研究科 血液浄化療法人材育成システム開発学   助教

    2021年4月 - 2021年12月

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  • 東海大学   基礎医学系 生体構造機能学   奨励研究員

    2019年4月 - 2021年3月

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  • 岡山大学   腎臓・糖尿病・内分泌科   医員

    2013年4月 - 2014年3月

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  • 倉敷中央病院   内科・腎臓内科   研修医

    2008年4月 - 2013年3月

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所属学協会

 

論文

  • A case of renal hypouricemia due to T217M mutation in SLC22A12 incidentally associated with IgA nephropathy. 査読 国際誌

    Yoshimasa Sakurabu, Haruhito A Uchida, Toshihisa Tahara, Tomohiko Asakawa, Haruka Yamasaki, Katsuyoshi Katayama, Shugo Okamoto, Yasuhiro Onishi, Natsumi Matsuoka-Uchiyama, Keiko Tanaka, Hidemi Takeuchi, Kenji Tsuji, Ryoko Umebayashi, Yuki Ohashi, Kimiyoshi Ichida, Jun Wada

    Clinical case reports   12 ( 9 )   e9368   2024年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A T217M heterozygous mutation in the SLC22A12 gene caused renal hypouricemia; this patient with IgA nephropathy had no findings other than IgA nephropathy on renal biopsy. Hypouricemia was susceptible to oxidative stress, but IgA nephropathy in the patient with hypouricemia could be treated with steroid pulse therapy without adverse events.

    DOI: 10.1002/ccr3.9368

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  • Targeted insertion of conditional expression cassettes into the mouse genome using the modified i-PITT. 査読 国際誌

    Hiromi Miura, Ayaka Nakamura, Aki Kurosaki, Ai Kotani, Masaru Motojima, Keiko Tanaka, Shigeru Kakuta, Sanae Ogiwara, Yuhsuke Ohmi, Hirotaka Komaba, Samantha L P Schilit, Cynthia C Morton, Channabasavaiah B Gurumurthy, Masato Ohtsuka

    BMC genomics   25 ( 1 )   568 - 568   2024年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Transgenic (Tg) mice are widely used in biomedical research, and they are typically generated by injecting transgenic DNA cassettes into pronuclei of one-cell stage zygotes. Such animals often show unreliable expression of the transgenic DNA, one of the major reasons for which is random insertion of the transgenes. We previously developed a method called "pronuclear injection-based targeted transgenesis" (PITT), in which DNA constructs are directed to insert at pre-designated genomic loci. PITT was achieved by pre-installing so called landing pad sequences (such as heterotypic LoxP sites or attP sites) to create seed mice and then injecting Cre recombinase or PhiC31 integrase mRNAs along with a compatible donor plasmid into zygotes derived from the seed mice. PITT and its subsequent version, improved PITT (i-PITT), overcome disadvantages of conventional Tg mice such as lack of consistent and reliable expression of the cassettes among different Tg mouse lines, and the PITT approach is superior in terms of cost and labor. One of the limitations of PITT, particularly using Cre-mRNA, is that the approach cannot be used for insertion of conditional expression cassettes using Cre-LoxP site-specific recombination. This is because the LoxP sites in the donor plasmids intended for achieving conditional expression of the transgene will interfere with the PITT recombination reaction with LoxP sites in the landing pad. RESULTS: To enable the i-PITT method to insert a conditional expression cassette, we modified the approach by simultaneously using PhiC31o and FLPo mRNAs. We demonstrate the strategy by creating a model containing a conditional expression cassette at the Rosa26 locus with an efficiency of 13.7%. We also demonstrate that inclusion of FLPo mRNA excludes the insertion of vector backbones in the founder mice. CONCLUSIONS: Simultaneous use of PhiC31 and FLP in i-PITT approach allows insertion of donor plasmids containing Cre-loxP-based conditional expression cassettes.

    DOI: 10.1186/s12864-024-10250-0

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  • Successful treatment for life threatening recurrent non-traumatic rectus sheath hematoma in a case with microscopic polyangiitis with rapidly progressive glomerulonephritis. 査読

    Hiroyuki Nakanoh, Hidemi Takeuchi, Morimoto Shiho, Yuya Terajima, Shugo Okamoto, Yasuhiro Onishi, Keiko Tanaka, Takayuki Katsuyama, Kenji Tsuji, Yoshinori Matsumoto, Katsuyuki Tanabe, Hiroshi Morinaga, Mayu Uka, Koji Tomita, Haruhito A Uchida, Takao Hiraki, Jun Wada

    Internal medicine (Tokyo, Japan)   2024年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    A 68-year-old woman was admitted to our hospital because of a rapid progression of renal dysfunction with positive myeloperoxidase antineutrophil cytoplasmic antibody and was diagnosed with rapidly progressive glomerulonephritis associated with microscopic polyangiitis (MPA). Severe right rectus sheath hematoma (RSH) bleeding from the inferior epigastric artery developed after starting hemodialysis, which required 4 transarterial embolizations due to recurrent bleeding. After additional treatment with methylprednisolone pulse therapy and rituximab, no rebleeding occurred. Although the giant hematoma reached the pelvis, it shrank spontaneously without any intervention. Nontraumatic RSH should therefore be considered when treating patients with multiple risk factors.

    DOI: 10.2169/internalmedicine.3239-23

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  • Dach1 is essential for maintaining normal mature podocytes. 査読 国際誌

    Keiko Tanaka, Haruko Hayasaka, Taiji Matsusaka

    PloS one   19 ( 5 )   e0303910   2024年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Dach1 is highly expressed in normal podocytes, but this expression rapidly disappears after podocyte injury. To investigate the role of Dach1 in podocytes in vivo, we analyzed global, podocyte-specific, and inducible Dach1 knockout mice. Global Dach1 knockout (Dach1-/-) mice were assessed immediately after birth because they die within a day. The kidneys of Dach1-/- mice were slightly smaller than those of control mice but maintained a normal structure and normal podocyte phenotypes, including ultrastructure. To study the role of Dach1 in mature podocytes, we generated Dach1 knockout mice by mating Dach1fl/fl mice with Nphs1-Cre or ROSA-CreERT2 mice. Due to inefficient Cre recombination, only a small number of podocytes lacked Dach1 staining in these mice. However, all eleven Nphs1-Cre/Dach1fl/fl mice displayed abnormal albuminuria, and seven (63%) of them developed focal segmental glomerulosclerosis. Among 13 ROSA-CreERT2/Dach1fl/fl mice, eight (61%) exhibited abnormal albuminuria after treatment with tamoxifen, and five (38%) developed early sclerotic lesions. These results indicate that while Dach1 does not determine the fate of differentiation into podocytes, it is indispensable for maintaining the normal integrity of mature podocytes.

    DOI: 10.1371/journal.pone.0303910

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  • Late-onset renal variant Fabry disease with R112H mutation and mild increase in plasma globotriaosylsphingosine: a case report. 査読 国際誌

    Keiko Tanaka, Hitoshi Sugiyama, Hiroshi Morinaga, Akifumi Onishi, Katsuyuki Tanabe, Haruhito A Uchida, Hiroki Maruyama, Jun Wada

    Frontiers in medicine   11   1383309 - 1383309   2024年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Fabry disease (FD) is an X-linked disorder resulting in a deficiency of α-galactosidase A (GLA) activity. The R112H mutation of GLA is relatively common in Japanese FD patients, characterized by a late-onset phenotype, almost normal to mild lyso-Gb3 elevation, and mild clinical symptoms, despite low GLA activity. This is due to the structural features of the R112H GLA protein. We herein report the case of a 42-year-old male patient with late-onset FD with a R112H mutation. The patient exhibited only renal involvement with no other organ damage and was successfully treated with galactosidase beta and subsequent migalastat for approximately 10 years. Especially, migalastat was clinically effective in normalizing plasma lyso-Gb3 levels and inhibiting the progression of renal damage associated with FD. Therefore, the use of migalastat in the FD patients with R112H mutation is highly recommended based on this case report.

    DOI: 10.3389/fmed.2024.1383309

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  • Elderly Brothers With Fabry Disease Exhibiting Cardiac and Renal Manifestations 査読

    Keiko Tanaka, Hitoshi Sugiyama, Hiroshi Morinaga, Akifumi Onishi, Yuzuki Kano, Hidemi Takeuchi, Kenji Tsuji, Motoki Kubo, Katsuyuki Tanabe, Haruhito A. Uchida, Kazufumi Nakamura, Jun Wada

    Annals of Internal Medicine: Clinical Cases   2 ( 5 )   2023年5月

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    担当区分:筆頭著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:American College of Physicians  

    DOI: 10.7326/aimcc.2022.1003

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  • The Effect of Medical Cooperation in the CKD Patients: 10-Year Multicenter Cohort Study. 査読 国際誌

    Yasuhiro Onishi, Haruhito A Uchida, Yohei Maeshima, Yuka Okuyama, Nozomu Otaka, Haruyo Ujike, Keiko Tanaka, Hidemi Takeuchi, Kenji Tsuji, Masashi Kitagawa, Katsuyuki Tanabe, Hiroshi Morinaga, Masaru Kinomura, Shinji Kitamura, Hitoshi Sugiyama, Kosuke Ota, Keisuke Maruyama, Makoto Hiramatsu, Yoshiyuki Oshiro, Shigeru Morioka, Keiichi Takiue, Kazuyoshi Omori, Masaki Fukushima, Naoyuki Gamou, Hiroshi Hirata, Ryosuke Sato, Hirofumi Makino, Jun Wada

    Journal of personalized medicine   13 ( 4 )   2023年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    INTRODUCTION: While chronic kidney disease (CKD) is one of the most important contributors to mortality from non-communicable diseases, the number of nephrologists is limited worldwide. Medical cooperation is a system of cooperation between primary care physicians and nephrological institutions, consisting of nephrologists and multidisciplinary care teams. Although it has been reported that multidisciplinary care teams contribute to the prevention of worsening renal functions and cardiovascular events, there are few studies on the effect of a medical cooperation system. METHODS: We aimed to evaluate the effect of medical cooperation on all-cause mortality and renal prognosis in patients with CKD. One hundred and sixty-eight patients who visited the one hundred and sixty-three clinics and seven general hospitals of Okayama city were recruited between December 2009 and September 2016, and one hundred twenty-three patients were classified into a medical cooperation group. The outcome was defined as the incidence of all-cause mortality, or renal composite outcome (end-stage renal disease or 50% eGFR decline). We evaluated the effects on renal composite outcome and pre-ESRD mortality while incorporating the competing risk for the alternate outcome into a Fine-Gray subdistribution hazard model. RESULTS: The medical cooperation group had more patients with glomerulonephritis (35.0% vs. 2.2%) and less nephrosclerosis (35.0% vs. 64.5%) than the primary care group. Throughout the follow-up period of 5.59 ± 2.78 years, 23 participants (13.7%) died, 41 participants (24.4%) reached 50% decline in eGFR, and 37 participants (22.0%) developed end-stage renal disease (ESRD). All-cause mortality was significantly reduced by medical cooperation (sHR 0.297, 95% CI 0.105-0.835, p = 0.021). However, there was a significant association between medical cooperation and CKD progression (sHR 3.069, 95% CI 1.225-7.687, p = 0.017). CONCLUSION: We evaluated mortality and ESRD using a CKD cohort with a long-term observation period and concluded that medical cooperation might be expected to influence the quality of medical care in the patients with CKD.

    DOI: 10.3390/jpm13040582

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  • Serum sCD40L and IL-31 in Association with Early Phase of IgA Nephropathy. 査読 国際誌

    Keiko Tanaka, Hitoshi Sugiyama, Hiroshi Morinaga, Masashi Kitagawa, Yuzuki Kano, Yasuhiro Onishi, Koki Mise, Katsuyuki Tanabe, Haruhito A Uchida, Jun Wada

    Journal of clinical medicine   12 ( 5 )   2023年3月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: IgA nephropathy (IgAN) is a major cause of chronic glomerulonephritis worldwide. T cell dysregulation has been reported to contribute to the pathogenesis of IgAN. Methods We measured a broad range of Th1, Th2 and Th17 cytokines in the serum of IgAN patients. We searched for significant cytokines, which were associated with clinical parameters and histological scores in IgAN patients. RESULTS: Among 15 cytokines, the levels of soluble CD40L (sCD40L) and IL-31 were higher in IgAN patients and were significantly associated with a higher estimated glomerular filtration rate (eGFR), a lower urinary protein to creatinine ratio (UPCR), and milder tubulointerstitial lesions (i.e., the early phase of IgAN). Multivariate analysis revealed that serum sCD40L was an independent determinant of a lower UPCR after adjustment for age, eGFR, and mean blood pressure (MBP). CD40, a receptor of sCD40L, has been reported to be upregulated on mesangial cells in IgAN. The sCD40L/CD40 interaction may directly induce inflammation in mesangial areas and may therefore be involved in the development of IgAN. CONCLUSIONS: The present study demonstrated the significance of serum sCD40L and IL-31 in the early phase of IgAN. Serum sCD40L may be a marker of the beginning of inflammation in IgAN.

    DOI: 10.3390/jcm12052023

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  • C-type lectin-like receptor (CLEC)-2, the ligand of podoplanin, induces morphological changes in podocytes. 査読 国際誌

    Keiko Tanaka, Masafumi Tanaka, Nobuo Watanabe, Masatoshi Ito, Ira Pastan, Masahiro Koizumi, Taiji Matsusaka

    Scientific reports   12 ( 1 )   22356 - 22356   2022年12月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Podoplanin (PDPN) is intensely expressed on the podocyte membrane in an evolutionally conserved manner. CLEC-2, the endogenous ligand of PDPN, is highly expressed in platelets and also exists in a soluble form in plasma. Normally, podocytes are sequestered from CLEC-2, but when the glomerular barrier is injured, podocytes gain access to CLEC-2. We tested the effects of CLEC-2 in podocytes in vitro and in vivo. Cultured podocytes treated with Fc-CLEC-2 demonstrated that CLEC-2 induced the dephosphorylation of ezrin, radixin, and moesin (ERM) proteins. Podocytes treated with Fc-CLEC-2 also showed the dissociation of F-actin filaments from PDPN, F-actin degradation, detachment, and round morphology. Next, we perfused normal mouse kidney in vivo with FLAG-CLEC-2. CLEC-2 induced dephosphorylation of ERM and widening of the foot processes of podocytes. Platelets were detected by immunostaining for CD41 in the urine of mice with podocyte injury, indicating that podocytes can encounter platelets when glomeruli are injured. Collectively, these observations suggest that when platelets leak through the injured glomeruli, CLEC-2 from the platelets acts on PDPN in podocytes and induces morphological change and detachment, which may further aggravate podocyte injury. Thus, PDPN on podocytes may work as a leaked-platelet sensor.

    DOI: 10.1038/s41598-022-26456-9

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  • Podocytes are lost from glomeruli before completing apoptosis. 査読 国際誌

    Kazuyoshi Yamamoto, Masahiro Okabe, Keiko Tanaka, Takashi Yokoo, Ira Pastan, Toshikazu Araoka, Kenji Osafune, Tomohiro Udagawa, Masahiro Koizumi, Taiji Matsusaka

    American journal of physiology. Renal physiology   323 ( 5 )   F515-F526   2022年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Although apoptosis of podocytes has been widely reported in in vitro studies, it has been less frequently and less definitively documented in in vivo situations. To investigate this discrepancy, we analyzed the dying process of podocytes in vitro and in vivo using LMB2, a human (h)CD25-directed immunotoxin. LMB2 induced cell death within 2 days in 56.8 ± 13.6% of cultured podocytes expressing hCD25 in a caspase-3, Bak1, and Bax-dependent manner. LMB2 induced typical apoptotic features, including TUNEL staining and fragmented nuclei without lactate dehydrogenase leakage. In vivo, LMB2 effectively eliminated hCD25-expressing podocytes in NEP25 mice. Podocytes injured by LMB2 were occasionally stained for cleaved caspase-3 and cleaved lamin A but never for TUNEL. Urinary sediment contained TUNEL-positive podocytes. To examine the effect of glomerular filtration, we performed unilateral ureteral obstruction in NEP25 mice treated with LMB2 1 day before euthanasia. In the obstructed kidney, glomeruli contained significantly more cleaved lamin A-positive podocytes than those in the contralateral kidney (50.1 ± 5.4% vs. 29.3 ± 4.1%, P < 0.001). To further examine the dying process without glomerular filtration, we treated kidney organoids generated from nephron progenitor cells of NEP25 mice with LMB2. Podocytes showed TUNEL staining and nuclear fragmentation. These results indicate that on activation of apoptotic caspases, podocytes are detached and lost in the urine before nuclear fragmentation and that the physical force of glomerular filtration facilitates detachment. This phenomenon may be the reason why definitive apoptosis is not observed in podocytes in vivo.NEW & NOTEWORTHY This report clarifies why morphologically definitive apoptosis is not observed in podocytes in vivo. When caspase-3 is activated in podocytes, these cells are immediately detached from the glomerulus and lost in the urine before DNA fragmentation occurs. Detachment is facilitated by glomerular filtration. This phenomenon explains why podocytes in vivo rarely show TUNEL staining and never apoptotic bodies.

    DOI: 10.1152/ajprenal.00080.2022

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  • Podocyte autophagy is associated with foot process effacement and proteinuria in patients with minimal change nephrotic syndrome. 査読 国際誌

    Ayu Ogawa-Akiyama, Hitoshi Sugiyama, Masashi Kitagawa, Keiko Tanaka, Yuzuki Kano, Koki Mise, Nozomu Otaka, Katsuyuki Tanabe, Hiroshi Morinaga, Masaru Kinomura, Haruhito A Uchida, Jun Wada

    PloS one   15 ( 1 )   e0228337   2020年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Autophagy is a cellular mechanism involved in the bulk degradation of proteins and turnover of organelle. Several studies have shown the significance of autophagy of the renal tubular epithelium in rodent models of tubulointerstitial disorder. However, the role of autophagy in the regulation of human glomerular diseases is largely unknown. The current study aimed to demonstrate morphological evidence of autophagy and its association with the ultrastructural changes of podocytes and clinical data in patients with idiopathic nephrotic syndrome, a disease in which patients exhibit podocyte injury. The study population included 95 patients, including patients with glomerular disease (minimal change nephrotic syndrome [MCNS], n = 41; idiopathic membranous nephropathy [IMN], n = 37) and 17 control subjects who underwent percutaneous renal biopsy. The number of autophagic vacuoles and the grade of foot process effacement (FPE) in podocytes were examined by electron microscopy (EM). The relationships among the expression of autophagic vacuoles, the grade of FPE, and the clinical data were determined. Autophagic vacuoles were mainly detected in podocytes by EM. The microtubule-associated protein 1 light chain 3 (LC3)-positive area was co-localized with the Wilms tumor 1 (WT1)-positive area on immunofluorescence microscopy, which suggested that autophagy occurred in the podocytes of patients with MCNS. The number of autophagic vacuoles in the podocytes was significantly correlated with the podocyte FPE score (r = -0.443, p = 0.004), the amount of proteinuria (r = 0.334, p = 0.033), and the level of serum albumin (r = -0.317, p = 0.043) in patients with MCNS. The FPE score was a significant determinant for autophagy after adjusting for the age in a multiple regression analysis in MCNS patients (p = 0.0456). However, such correlations were not observed in patients with IMN or in control subjects. In conclusion, the results indicated that the autophagy of podocytes is associated with FPE and severe proteinuria in patients with MCNS. The mechanisms underlying the activation of autophagy in association with FPE in podocytes should be further investigated in order to elucidate the pathophysiology of MCNS.

    DOI: 10.1371/journal.pone.0228337

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  • Urine 5MedC, a Marker of DNA Methylation, in the Progression of Chronic Kidney Disease. 査読 国際誌

    Onishi A, Sugiyama H, Kitagawa M, Yamanari T, Tanaka K, Ogawa-Akiyama A, Kano Y, Mise K, Tanabe K, Morinaga H, Kinomura M, Uchida HA, Wada J

    Disease markers   2019   5432453 - 5432453   2019年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1155/2019/5432453

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  • Renal expression of trefoil factor 3 mRNA in association with tubulointerstitial fibrosis in IgA nephropathy. 査読 国際誌

    Tanaka K, Sugiyama H, Yamanari T, Mise K, Morinaga H, Kitagawa M, Onishi A, Ogawa-Akiyama A, Tanabe K, Eguchi J, Ohmoto Y, Shikata K, Wada J

    Nephrology (Carlton, Vic.)   23 ( 9 )   855 - 862   2018年9月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/nep.13444

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  • Serum cystatin C is an independent biomarker associated with the renal resistive index in patients with chronic kidney disease 査読

    Ayu Ogawa-Akiyama, Hitoshi Sugiyama, Masashi Kitagawa, Keiko Tanaka, Akifumi Onishi, Toshio Yamanari, Hiroshi Morinaga, Haruhito Adam Uchida, Kazufumi Nakamura, Hiroshi Ito, Jun Wada

    PLoS ONE   13 ( 3 )   e0193695   2018年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Public Library of Science  

    Cystatin C is a cysteine protease inhibitor that is produced by nearly all human cells. The serum level of cystatin C is a stronger predictor of the renal outcome and the risk of cardiovascular events than the creatinine level. The resistive index (RI) on renal Doppler ultrasonography is a good indicator of vascular resistance as well as the renal outcomes in patients with chronic kidney disease (CKD). However, it is unclear whether serum cystatin C is associated with signs of vascular dysfunction, such as the renal RI. We measured the serum cystatin C levels in 101 CKD patients and investigated the relationships between cystatin C and markers of vascular dysfunction, including the renal RI, ankle-brachial pulse wave velocity (baPWV), intima-media thickness (IMT), and cardiac function. The renal RI was significantly correlated with the serum cystatin C level (p &lt
    0.0001, r = 0.6920). The serum cystatin C level was found to be a significant determinant of the renal RI (p &lt
    0.0001), but not the baPWV, in a multivariate regression analysis. The multivariate odds ratio of the serum cystatin C level for a renal RI of more than 0.66 was statistically significant (2.92, p = 0.0106). The area under the receiver-operating characteristic curve comparing the sensitivity and specificity of cystatin C for predicting an RI of more than 0.66 was 0.882 (cutoff value: 2.04 mg/L). In conclusion, the serum cystatin C level is an independent biomarker associated with the renal RI in patients with CKD.

    DOI: 10.1371/journal.pone.0193695

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  • Urine trefoil factors as prognostic biomarkers in chronic kidney disease 査読

    Toshio Yamanari, Hitoshi Sugiyama, Keiko Tanaka, Hiroshi Morinaga, Masashi Kitagawa, Akifumi Onishi, Ayu Ogawa-Akiyama, Yuzuki Kano, Koki Mise, Yasukazu Ohmoto, Kenichi Shikata, Jun Wada

    BioMed Research International   2018   3024698   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:Hindawi Limited  

    Introduction. Trefoil factor family (TFF) peptides are increased in serum and urine in patients with chronic kidney disease (CKD). However, whether the levels of TFF predict the progression of CKD remains to be elucidated. Methods. We determined the TFF levels using peptide-specific ELISA in spot urine samples and performed a prospective cohort study. The association between the levels of urine TFFs and other urine biomarkers as well as the renal prognosis was analyzed in 216 CKD patients (mean age: 53.7 years, 47.7% female, 56.9% with chronic glomerulonephritis, and mean EGFR: 58.5 ml/min/1.73 m2). Results. The urine TFF1 and TFF3 levels significantly increased with the progression of CKD stages, but not the urine TFF2 levels. The TFF1 and TFF3 peptide levels predicted the progression of CKD ≥ stage 3b by ROC analysis (AUC 0.750 and 0.879, resp.)
    however, TFF3 alone predicted CKD progression in a multivariate logistic regression analysis (odds ratio 3.854, 95% confidence interval 1.316-11.55). The Kaplan-Meier survival curves demonstrated that patients with a higher TFF1 and TFF3 alone, or in combination with macroalbuminuria, had a significantly worse renal prognosis. Conclusion. The data suggested that urine TFF peptides are associated with renal progression and the outcomes in patients with CKD.

    DOI: 10.1155/2018/3024698

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  • Primary peritoneal carcinosarcoma in a dialysis patient 査読

    Keiko Tanaka, Katsuyuki Tanabe, Naoko Nishii, Kana Masuda, Yuka Arata, Akifumi Ohnishi, Masaru Kinomura, Hitoshi Sugiyama, Jun Wada

    NEPHROLOGY   22 ( 11 )   925 - 925   2017年11月

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    担当区分:筆頭著者   記述言語:英語   出版者・発行元:WILEY  

    DOI: 10.1111/nep.12973

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  • Arterial Stiffness is an Independent Risk Factor for Anemia After Percutaneous Native Kidney Biopsy 査読

    Keiko Tanaka, Masashi Kitagawa, Akifumi Onishi, Toshio Yamanari, Ayu Ogawa-Akiyama, Koki Mise, Tatsuyuki Inoue, Hiroshi Morinaga, Haruhito A. Uchida, Hitoshi Sugiyama, Jun Wada

    KIDNEY & BLOOD PRESSURE RESEARCH   42 ( 2 )   284 - 293   2017年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:KARGER  

    Background/Aims: Bleeding is the most common complication after renal biopsy. Although numerous predictors of bleeding have been reported, it remains unclear whether arterial stiffness affects bleeding complications. Method: We performed an observational study of the renal biopsies performed in our division over an approximately 6-year period (May 2010 to May 2016). The clinical and laboratory factors were analyzed to reveal the risk factors associated with bleeding, with a focus on anemia (defined as a &gt;= 10% decrease in hemoglobin [Hb] after biopsy). The brachial-ankle pulse wave velocity (baPWV) was measured to evaluate arterial stiffness. Results: This study included 462 patients (male, n=244; female, n=218). Anemia (defined above) was observed in 54 patients (11.7%). The risk of anemia was higher in women, older patients, and patients with lower serum albumin, lower eGFR and lower diastolic blood pressure after biopsy. We then performed a further analysis of 187 patients whose baPWV data were available. Multivariate analysis revealed that a higher baPWV was an independent risk factor for anemia. ROC analysis for predicting anemia found that a baPWV value of 1839 cm/s had the best performance (AUC 0.689). Conclusion: An increased baPWV may be a more valuable predictor of bleeding than any of the other reported risk factors. (C) 2017 The Author(s) Published by S. Karger AG, Basel

    DOI: 10.1159/000477453

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  • Sustained Tubulointerstitial Inflammation in Kidney with Severe Leptospirosis 査読

    Keiko Tanaka, Katsuyuki Tanabe, Naoko Nishii, Keiichi Takiue, Hitoshi Sugiyama, Jun Wada

    INTERNAL MEDICINE   56 ( 10 )   1179 - 1184   2017年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    Leptospirosis is frequently associated with acute kidney injury. Some survivors are known to progress to chronic kidney disease due to sustained tubulointerstitial inflammation. We present a case of severe leptospirosis with acute renal failure. Although antibiotic therapy resolved the infection, moderate renal dysfunction remained. A renal biopsy demonstrated marked inflammatory infiltration in the tubules and interstitium. Many of the inflammatory cells were CD68-positive monocytes/macrophages, predominantly M1 phenotype. An intermediate dose of oral corticosteroids normalized the patient's serum creatinine levels. We suggest that corticosteroid therapy may be a therapeutic option for some patients with sustained tubulointerstitial nephritis who survive severe leptospirosis.

    DOI: 10.2169/internalmedicine.56.8084

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  • The possible involvement of intestine-derived IgA(1): a case of IgA nephropathy associated with Crohn's disease 査読

    Tomohiro Terasaka, Haruhito A. Uchida, Ryoko Umebayashi, Keiko Tsukamoto, Keiko Tanaka, Masashi Kitagawa, Hitoshi Sugiyama, Hiroaki Tanioka, Jun Wada

    BMC NEPHROLOGY   17 ( 1 )   122   2016年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BIOMED CENTRAL LTD  

    Background: A link between IgA nephropathy and Crohn's disease has recently been reported. Other researchers hypothesize that intestine-derived IgA complexes deposit in glomerular mesangial cells, eliciting IgA nephropathy. Intestinal mucosal plasma cells mainly secrete IgA(2). Nevertheless, IgA(1) deposition is strongly implicated as being the primary cause of IgA nephropathy.
    Case presentation: A 46-year-old Japanese man developed IgA nephropathy 29 years ago, following tonsillectomy. As a result, a normal urinalysis was obtained. The patient previously suffered Crohn's disease followed by urinary occult blood and proteinuria six years ago. Exacerbation of IgA nephropathy was highly suspected. Therefore a renal biopsy was performed. A diagnosis of exacerbation of IgA nephropathy with mesangial cell proliferation and fibrotic cellular crescent was based upon the pathological findings. The patient exhibited a positive clinical course and eventually achieved a remission with immunosuppressive therapy including prednisolone treatment. Immunostaining for the detection of IgA subtypes was performed on both of his kidney and excised ileum. The results revealed IgA(1) and IgA(2) deposition by submucosal cells in intestine. Furthermore, IgA(1) deposition of mesangial areas in the patient's kidney, indicated an association of IgA(1) with the exacerbation of IgA nephropathy.
    Conclusion: This case represents the possibility that the intestine-derived IgA(1) can be the origin of galactose-deficient IgA which is known to cause IgA nephropathy exacerbation.

    DOI: 10.1186/s12882-016-0344-1

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  • 潰瘍性大腸炎に合併した腎血管性高血圧の1例 査読

    田中 景子, 内田 治仁, 平松 澄恵, 天田 雅文, 井上 章子, 奥山 由加, 梅林 亮子, 郷原 英夫, 大澤 晋, 平岡 佐規子, 寺坂 律子, 杉山 斉, 和田 淳

    脈管学   54 ( 10 )   167 - 172   2014年10月

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    担当区分:筆頭著者   記述言語:日本語   出版者・発行元:(一社)日本脈管学会  

    腎血管性高血圧はさまざまな疾患を原因とする。今回我々は、潰瘍性大腸炎に腎血管性高血圧を合併した症例を経験した。症例は40歳男性。造影CTと血管造影で右腎動脈の閉塞と側副血行路の発達を認めた。さらに左腎区域動脈と肝動脈の狭小化、両側内腸骨動脈の閉塞と腹部大動脈の一部壁不整がみられた。FDG-PETで大動脈炎症候群は否定的であった。皮疹や結腸粘膜の生検で血管炎の所見は得られず、診断に苦慮した症例であった。(著者抄録)

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    その他リンク: https://search.jamas.or.jp/default/link?pub_year=2014&ichushi_jid=J01422&link_issn=&doc_id=20141212320002&doc_link_id=10.7133%2Fjca.14-00031&url=https%3A%2F%2Fdoi.org%2F10.7133%2Fjca.14-00031&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

  • Acoustic Radiation Force Impulse Elastography of the Kidneys Is Shear Wave Velocity Affected by Tissue Fibrosis or Renal Blood Flow? 査読

    Kenichiro Asano, Ai Ogata, Keiko Tanaka, Yoko Ide, Akiko Sankoda, Chieko Kawakita, Mana Nishikawa, Kazuyoshi Ohmori, Masaru Kinomura, Noriaki Shimada, Masaki Fukushima

    JOURNAL OF ULTRASOUND IN MEDICINE   33 ( 5 )   793 - 801   2014年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER INST ULTRASOUND MEDICINE  

    Objectives-The aim of this study was to identify the main influencing factor of the shear wave velocity (SWV) of the kidneys measured by acoustic radiation force impulse elastography.
    Methods-The SWV was measured in the kidneys of 14 healthy volunteers and 319 patients with chronic kidney disease. The estimated glomerular filtration rate was calculated by the serum creatinine concentration and age. As an indicator of arteriosclerosis of large vessels, the brachial-ankle pulse wave velocity was measured in 183 patients.
    Results-Compared to the degree of interobserver and intraobserver deviation, a large variance of SWV values was observed in the kidneys of the patients with chronic kidney disease. Shear wave velocity values in the right and left kidneys of each patient correlated well, with high correlation coefficients (r = 0.580-0.732). The SWV decreased concurrently with a decline in the estimated glomerular filtration rate. A low SWV was obtained in patients with a high brachial-ankle pulse wave velocity. Despite progression of renal fibrosis in the advanced stages of chronic kidney disease, these results were in contrast to findings for chronic liver disease, in which progression of hepatic fibrosis results in an increase in the SWV. Considering that a high brachial-ankle pulse wave velocity represents the progression of arteriosclerosis in the large vessels, the reduction of elasticity succeeding diminution of blood flow was suspected to be the main influencing factor of the SWV in the kidneys.
    Conclusions-This study indicates that diminution of blood flow may affect SWV values in the kidneys more than the progression of tissue fibrosis. Future studies for reducing data variance are needed for effective use of acoustic radiation force impulse elastography in patients with chronic kidney disease.

    DOI: 10.7863/ultra.33.5.793

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  • CKD stage3において冠動脈形成術(PCI)後に乏尿性の急性腎障害(AKI)を発症し血液透析を要した6例の検討 査読

    田中 景子, 島田 典明, 井出 陽子, 三小田 亜希子, 緒方 愛衣, 澤田 真理子, 大森 一慶, 木野村 賢, 大鶴 優, 門田 一繁, 福島 正樹, 浅野 健一郎

    中国腎不全研究会誌   21   169 - 170   2012年12月

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    担当区分:筆頭著者   記述言語:日本語   出版者・発行元:(一社)中国腎不全研究会  

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  • 糖尿病性腎症に紫斑病性腎炎を合併した1例 査読

    田中 景子, 梅林 亮子, 伊澤 正一郎, 島田 典明, 浅野 健一郎, 福島 正樹

    倉敷中央病院年報   72   213 - 217   2010年3月

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    担当区分:筆頭著者   記述言語:日本語   出版者・発行元:(公財)大原記念倉敷中央医療機構倉敷中央病院  

    症例は77歳の女性で,10年来の糖尿病歴があった.2008年11月に初めて尿蛋白を指摘され,その後およそ2ヵ月で急速に腎機能が低下した.同時にネフローゼ症候群を合併しており,extracorporeal ultrafiltration method(ECUM)でうっ血が改善した後も,胸水や全身浮腫は残存した.炎症反応の上昇を認めていたが,抗菌薬で改善せず,全身状態から腎生検での診断確定は困難であった.第12病日に下腿の紫斑を認めた.紫斑病性腎炎の合併を強く疑い,ステロイド療法を開始したところ,腎機能,尿蛋白や胸水は速やかに改善した.全身状態が落ち着いた第43病日に腎生検を施行し,糖尿病性腎症に紫斑病性腎炎を合併していることを確認した.糖尿病性腎症に他の腎疾患の合併が疑われる場合には,正確に病態把握し全身状態から総合的に判断して治療をすすめてゆく必要がある.(著者抄録)

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MISC

  • 岡山市CKDネットワーク(OCKD-NET)2の登録2年後のデータ解析

    田中 景子, 内田 治仁, 大西 康博, 岡本 修吾, 竹内 英実, 辻 憲二, 田邊 克幸, 森永 裕士, 太田 康介, 丸山 啓輔, 大城 義之, 森岡 茂, 瀧上 慶一, 蒲生 直幸, 杉山 斉, 和田 淳

    日本腎臓学会誌   66 ( 4 )   677 - 677   2024年6月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • 当院における非外傷性腹直筋血腫5症例の報告

    中納弘幸, 竹内英実, 森本志帆, 寺嶋悠也, 岡本修吾, 大西康博, 田中景子, 勝山隆行, 辻憲二, 田邊克幸, 森永裕士, 宇賀麻由, 冨田晃司, 平木隆夫, 内田治仁, 和田淳

    中国腎不全研究会誌   32   2024年

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  • 平滑筋肉腫の両側腎臓への転移に対して両腎摘出術を契機に血液透析導入とした一例

    浅川知彦, 竹内英実, 岡本修吾, 大西康博, 田中景子, 辻憲二, 田邊克幸, 森永裕士, 内田治仁, 和田淳

    中国腎不全研究会誌   32   2024年

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  • Behcet病の経過中にIgA腎症を合併し,ステロイド療法とコルヒチン併用により蛋白尿の大幅な改善を認めた一例

    浅川 知彦, 内田 治仁, 片山 祐, 田中 景子, 竹内 英実, 辻 憲二, 梅林 亮子, 田邊 克幸, 森永 裕士, 和田 淳

    日本腎臓学会誌   65 ( 6-W )   755 - 755   2023年9月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • 検尿異常の精査中に発見したIgA腎症に腎性低尿酸血症が合併した1例

    櫻武 敬真, 内田 治仁, 田原 稔久, 山崎 遥香, 大西 康博, 田中 景子, 竹内 英実, 辻 憲二, 梅林 亮子, 和田 淳

    日本腎臓学会誌   65 ( 6-W )   810 - 810   2023年9月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • 医学生に対する腎セミナー開催についての検討

    辻 憲二, 岡本 修吾, 大西 康博, 田中 景子, 竹内 英実, 田邊 克幸, 森永 裕士, 内田 治仁, 喜多村 真治, 和田 淳

    日本腎臓学会誌   65 ( 3 )   326 - 326   2023年5月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • 岡山市CKDネットワーク(OCKD-NET)2の登録時データ解析 OCKD-NET1との比較

    田中 景子, 内田 治仁, 大西 康博, 岡本 修吾, 竹内 英実, 辻 憲二, 田邊 克幸, 森永 裕士, 太田 康介, 丸山 啓輔, 大城 義之, 森岡 茂, 瀧上 慶一, 蒲生 直幸, 杉山 斉, 和田 淳

    日本腎臓学会誌   65 ( 3 )   268 - 268   2023年5月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • ゆで卵を用いた模擬腎生検 コロンブスの卵

    辻 憲二, 田中 景子, 竹内 英実, 田邊 克幸, 森永 裕士, 木野村 賢, 内田 治仁, 喜多村 真治, 杉山 斉, 和田 淳

    日本腎臓学会誌   64 ( 3 )   297 - 297   2022年5月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • 動脈硬化ではなく細動脈硝子化は糸球体全節性硬化と独立して尿細管間質病変と関連する

    北川 正史, 杉山 斉, 加納 弓月, 山成 俊夫, 田中 景子, 大西 章史, 内田 治仁, 和田 淳

    日本腎臓学会誌   60 ( 3 )   370 - 370   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • baPWVによる動脈硬化評価は腎生検後の貧血進行の予測因子となる

    田中 景子, 北川 正史, 大西 章史, 山成 俊夫, 秋山 愛由, 三瀬 広記, 森永 裕士, 内田 治仁, 杉山 斉, 和田 淳

    日本腎臓学会誌   59 ( 3 )   345 - 345   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • 腎内細動脈硝子化、動脈硬化病変は全身の動脈硬化指標の異なる因子が規定する

    北川 正史, 杉山 斉, 大西 章史, 山成 俊夫, 田中 景子, 三瀬 広記, 森永 裕士, 内田 治仁, 和田 淳

    日本腎臓学会誌   59 ( 3 )   309 - 309   2017年4月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • 血清と尿中TFF3の上昇は、間質性腎炎の線維化と相関する

    田中 景子, 杉山 斉, 山成 俊夫, 秋山 愛由, 大西 章史, 北川 正史, 森永 裕士, 菊本 陽子, 井上 達之, 和田 淳

    日本腎臓学会誌   58 ( 3 )   259 - 259   2016年5月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • 非糖尿病慢性腎臓病患者において、FGF21は拡張機能、FGF23は収縮機能と関連する

    北川 正史, 杉山 斉, 井上 達之, 森永 裕士, 秋山 愛由, 山成 俊夫, 大西 章史, 田中 景子, 井上 章子, 菊本 陽子, 和田 淳

    日本腎臓学会誌   58 ( 3 )   274 - 274   2016年5月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • クローン病に合併したIgA腎症の1例

    寺坂 友博, 内田 治仁, 梅林 亮子, 塚本 啓子, 田中 景子, 北川 正史, 杉山 斉, 和田 淳, 谷岡 洋亮

    日本腎臓学会誌   57 ( 6 )   1126 - 1126   2015年8月

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  • 肺高血圧症を合併する全身性強皮症への血液透析導入例

    田邊 克幸, 田中 景子, 竹内 英実, 澁藤 宣行, 大西 章史, 益田 加奈, 荒田 夕佳, 寺見 直人, 秋山 愛由, 木野村 賢, 藤井 泰宏, 大澤 晋, 杉山 斉, 和田 淳

    日本透析医学会雑誌   48 ( Suppl.1 )   940 - 940   2015年5月

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    記述言語:日本語   出版者・発行元:(一社)日本透析医学会  

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  • IgA腎症における指定難病症例の解析

    田中 景子, 井上 達之, 大西 章史, 山成 俊夫, 秋山 愛由, 北川 正史, 森永 裕士, 菊本 陽子, 杉山 斉, 和田 淳

    日本腎臓学会誌   57 ( 3 )   464 - 464   2015年4月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • 多発性嚢胞腎における指定難病重症度分類の評価に関する検討

    大西 章史, 杉山 斉, 田中 景子, 山成 俊夫, 秋山 愛由, 北川 正史, 森永 裕士, 井上 達之, 菊本 陽子, 田邊 克幸, 木野村 賢, 花山 宣久, 内田 治仁, 喜多村 真治, 和田 淳

    日本腎臓学会誌   57 ( 3 )   553 - 553   2015年4月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • 血中FGF21は腎機能、蛋白尿と独立した腎予後を予測するバイオマーカーである

    北川 正史, 杉山 斉, 森永 裕士, 秋山 愛由, 山成 俊夫, 大西 章史, 田中 景子, 菊本 陽子, 井上 達之, 内田 治仁, 和田 淳

    日本腎臓学会誌   57 ( 3 )   465 - 465   2015年4月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • インターフェロン(IFN)が著効した生体肝移植後HCV陽性の膜性増殖性糸球体腎炎(MPGN)の1例

    田中 景子, 内田 治仁, 井上 章子, 雛元 紀和, 北川 正史, 高木 章乃夫, 杉山 斉, 和田 淳

    日本腎臓学会誌   56 ( 6 )   702 - 702   2014年8月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • 2型糖尿病の経過中にBasedow病を発症した1例

    布上 朋和, 江口 潤, 寺見 隆宏, 田中 景子, 平松 澄恵, 小松原 基志, 和田 淳, 四方 賢一, 槇野 博史

    糖尿病   57 ( 8 )   654 - 654   2014年8月

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    記述言語:日本語   出版者・発行元:(一社)日本糖尿病学会  

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  • 急性腎不全、高度肝障害と血小板減少を呈した重症レプトスピラ症の1例

    田中 景子, 田邊 克幸, 西井 尚子, 瀧上 慶一, 大西 章史, 寺見 直人, 山成 俊夫, 中山 和典, 綿谷 博雪, 井上 淳子, 益田 加奈, 杉山 斉, 槇野 博史

    日本透析医学会雑誌   47 ( Suppl.1 )   484 - 484   2014年5月

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    記述言語:日本語   出版者・発行元:(一社)日本透析医学会  

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  • 化学療法中に発生した血液透析を要する急性腎不全症例の検討

    田邊 克幸, 田中 景子, 小松原 基志, 大西 章史, 寺見 直人, 中山 和典, 綿谷 博雪, 益田 加奈, 井上 淳子, 山成 俊夫, 森永 裕士, 杉山 斉, 槇野 博史

    日本透析医学会雑誌   47 ( Suppl.1 )   1011 - 1011   2014年5月

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    記述言語:日本語   出版者・発行元:(一社)日本透析医学会  

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  • 透析液重炭酸濃度の低減により透析中のCO2ナルコーシスを防げた高齢の慢性高CO2血症の2例

    緒方 愛衣, 島田 典明, 田中 景子, 三小田 亜希子, 井出 陽子, 金 仁毅, 西川 真那, 澤田 真理子, 木野村 賢, 福島 正樹, 浅野 健一郎

    日本透析医学会雑誌   47 ( 3 )   209 - 215   2014年3月

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    記述言語:日本語   出版者・発行元:(一社)日本透析医学会  

    透析液重炭酸濃度の低減によりCO2ナルコーシスを防ぎ血液透析(HD)を継続できた高齢透析患者の2例を報告する。症例1は77歳女性。糖尿病性腎症による慢性腎不全でHD歴5年。HD施行中にCO2ナルコーシスをきたし、HDを中断し非侵襲陽圧換気療法(NPPV)を開始した。次のHDでは透析液重炭酸濃度を30mmol/Lから25mmol/Lに変更したが、HD中にCO2ナルコーシスがみられHDを中断した。重炭酸濃度を22mmol/Lまで低減したところCO2ナルコーシスをきたすことなくHDを継続できた。症例2は76歳女性。ANCA関連腎炎による慢性腎不全でHD歴1年半。HD中にCO2ナルコーシスを認め、HDを中断しNPPVを開始した。その後、透析液重炭酸濃度を22mmol/Lに調節したところHD中にシャント血CO2濃度の増悪をきたすことなくHDを継続できた。2例とも生活活動度の低い、るい痩のある高齢透析患者で慢性の高CO2血症がみられており、呼吸筋力低下による換気障害が考えられた。HD中にCO2ナルコーシスをきたしたが、機序としては、重炭酸負荷により血中CO2は上昇する(HCO3-+H+⇒H2CO3⇒CO2+H2O)がCO2排出障害のため高CO2血症を是正できないことや、急激な重炭酸負荷による呼吸抑制が考えられている。慢性の高CO2血症の症例ではHDによる急速なアルカリ化により呼吸状態が悪化することが懸念される。本症例では透析液重炭酸濃度の低減によりHD中の高CO2血症の増悪は認めず、代謝性アシドーシスの悪化をきたすことなくHDを継続することができた。呼吸性アシドーシスと代謝性アシドーシスの併存例でHD中にCO2ナルコーシスをきたす場合には透析液重炭酸濃度の低減は有用な手段と考える。(著者抄録)

    DOI: 10.4009/jsdt.47.209

    CiNii Article

    CiNii Books

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    その他リンク: https://jlc.jst.go.jp/DN/JALC/10031453553?from=CiNii

  • 頭蓋内出血急性期にSLED(sustained low efficiency dialysis)で管理をした維持血液透析の3例

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    中国腎不全研究会誌   21   117 - 118   2012年12月

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    記述言語:日本語   出版者・発行元:中国腎不全研究会  

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  • 妊娠中に種々の体液評価を行い生児が得られた透析患者の1例

    井出 陽子, 島田 典明, 柏原 亜希子, 緒方 愛衣, 田中 景子, 金 仁毅, 澤田 真理子, 木野村 賢, 角田 光男, 福島 正樹, 浅野 健一郎

    日本透析医学会雑誌   45 ( Suppl.1 )   949 - 949   2012年5月

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    記述言語:日本語   出版者・発行元:(一社)日本透析医学会  

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  • 冠動脈造影(CAG)・冠動脈形成術(PCI)後に乏尿性腎不全を発症し血液透析を要した9例の検討

    田中 景子, 島田 典明, 井出 陽子, 柏原 亜希子, 緒方 愛衣, 金 仁毅, 澤田 真理子, 木野村 賢, 副島 正樹, 浅野 健一郎

    日本透析医学会雑誌   45 ( Suppl.1 )   408 - 408   2012年5月

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    記述言語:日本語   出版者・発行元:(一社)日本透析医学会  

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  • 悪性腫瘍治療が膜性腎症に及ぼす効果の検討

    緒方 愛衣, 島田 典明, 井出 陽子, 柏原 亜希子, 田中 景子, 金 仁毅, 木野村 賢, 福島 正樹, 浅野 健一郎

    日本腎臓学会誌   54 ( 3 )   247 - 247   2012年4月

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    記述言語:日本語   出版者・発行元:(一社)日本腎臓学会  

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  • 肺外結核の診断に1,25-(OH)2D3高値が有用であった導入期透析患者の1例

    柏原 亜希子, 島田 典明, 井出 陽子, 緒方 愛衣, 田中 景子, 金 仁毅, 澤田 真理子, 木野村 賢, 福島 正樹, 浅野 健一郎

    中国腎不全研究会誌   20   97 - 98   2012年1月

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    記述言語:日本語   出版者・発行元:中国腎不全研究会  

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▼全件表示

受賞

  • 2021年度 研究活動奨励賞

    2022年7月   日本女性腎臓病医の会(JSWN)   傷害糸球体に作用する血小板分子CLEC-2の効果

    田中景子

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  • 優秀演題賞

    2017年6月   日本腎臓学会学術総会   baPWVによる動脈硬化評価は腎生検後の貧血進行の予測因子となる

    田中 景子

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共同研究・競争的資金等の研究

  • 活性化血小板と傷害ポドサイトに着目した慢性腎臓病進展機序の解明

    2024年04月 - 2027年03月

    日本学術振興会 科学研究費補助金 基盤研究C 

    田中景子

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  • 傷害糸球体のポドサイトに作用する血小板分子CLEC-2の効果

    2020年04月 - 2023年03月

    日本学術振興会 科学研究費補助金 若手研究 

    田中 景子

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  • 尿細管由来蛋白を指標とした慢性腎臓病の予後予測と線維化進展機序の解明

    2018年04月 - 2020年03月

    日本学術振興会  科学研究費補助金 若手研究 

    田中 景子

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    担当区分:研究代表者  資金種別:競争的資金

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