Faculty Profiles - IIDA Seiji

Papers - IIDA Seiji

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Role of oral sensory and serotonergic neurons in dopamine-induced tongue movement in rat

Takeshi Harada, Seiji Iida, Yoshiki Inada, Susumu Tanaka, Yoshinosuke Hamada, Mikihiko Kogo

Nano Biomedicine 12 ( 2 ) 53 - 60 2020

Publishing type：Research paper (scientific journal)

Background: Oral dyskinesia is a condition in which oral organs exhibit involuntary movements. The aim of this study was to determine the contribution of oral sensation to the control of oral dyskinesia using an animal model that exhibits vacuous tongue movements after systemic administration of dopamine (DA) agonists. Methods: Adult male Sprague-Dawley rats were used in all experiments. Tongue movement was elicited in a freely moving rat model by systemic administration of a mixture of the D1 receptor agonist SKF38393 and the D2 receptor agonist quinpirole. The number of tongue protrusions was calculated from electrical myographic data obtained from the genioglossal muscle. Extracellular concentrations of DA and serotonin (5-HT) in the nucleus accumbens were determined using in vivo microdialysis. To investigate the effects of oral sensation on vacuous tongue movement, deafferentation of the palatal mucosa was performed, and the above experiments were repeated. Results: The hyperactivity of tongue protrusion induced by administration of SKF38393 and quinpirole was significantly inhibited by palatal deafferentation. Palatal deafferentation also significantly reduced the increase in extracellular 5-HT concentration in the nucleus accumbens produced by administration of DA agonists. Conclusions: These results support the important contribution of oral sensation to vacuous tongue protrusion in a rat model of oral dyskinesia.

DOI： 10.11344/nano.12.53

Histological differences related to autophagy in the minor salivary gland between primary and secondary types of Sjögren's syndrome. International journal

Hitomi Ono-Minagi, Tsutomu Nohno, Kiyofumi Takabatake, Takehiro Tanaka, Takayuki Katsuyama, Kohta Miyawaki, Jun Wada, Soichiro Ibaragi, Seiji Iida, Tadashi Yoshino, Hitoshi Nagatsuka, Takayoshi Sakai, Hideyo Ohuchi

BMC oral health 24 ( 1 ) 1099 - 1099 2024.9

Language：English Publishing type：Research paper (scientific journal)

Some forms of Sjögren's syndrome (SS) follow a clinical course accompanied by systemic symptoms caused by lymphocyte infiltration and proliferation in the liver, kidneys, and other organs. To better understand the clinical outcomes of SS, here we used minor salivary gland tissues from patients and examine their molecular, biological, and pathological characteristics. A retrospective study was performed, combining clinical data and formalin-fixed paraffin-embedded (FFPE) samples from female patients over 60 years of age who underwent biopsies at Okayama University Hospital. We employed direct digital RNA counting with nCounter® and multiplex immunofluorescence analysis with a PhenoCycler™ on the labial gland biopsies. We compared FFPE samples from SS patients who presented with other connective tissue diseases (secondary SS) with those from stable SS patients with symptoms restricted to the exocrine glands (primary SS). Secondary SS tissues showed enhanced epithelial damage and lymphocytic infiltration accompanied by elevated expression of autophagy marker genes in the immune cells of the labial glands. The close intercellular distance between helper T cells and B cells positive for autophagy-associated molecules suggests accelerated autophagy in these lymphocytes and potential B cell activation by helper T cells. These findings indicate that examination of FFPE samples from labial gland biopsies can be an effective tool for evaluating molecular histological differences between secondary and primary SS through multiplexed analysis of gene expression and tissue imaging.

DOI： 10.1186/s12903-024-04869-4

Migrationにより下顎骨下縁より歯根が突出した異所性埋伏智歯の一例

永田裕樹, 天野克比古, 武田斉子, 中辻和樹, 飯田征二

日本口腔科学会雑誌 73 ( 2 ) 106 - 107 2024.9

【埋伏歯について】埋伏歯・萠出障害の歯の診断と治療

飯田征二

小児歯科臨床 29 ( 8 ) 28 - 37 2024.8

The Endoscopic Removal of a Detached Dental Implant Cap in the Maxillary Sinus During the Waiting Period: A Case Report. International journal

Katsuhiko Amano, Chiaki Nishizawa, Yohei Maeda, Susumu Tanaka, Seiji Iida

Cureus 16 ( 6 ) e63243 2024.6

Language：English Publishing type：Research paper (scientific journal)

Displacement of dental implants into the maxillary sinus is one of the common dental complications. However, it is rare that dental implants cause the displacement of multiple components due to separation. Here, we describe an unusual case of a 43-year-old man who had a missing implant in the maxillary sinus after an implant procedure. There was a two-week waiting period before we performed the removal during which the cap had unexpectedly separated from the body and freely moved into the ostium by sinus activity. The body was independently extracted intraorally. The remaining cap was secondly removed by utilizing nasal endoscopy. There were no complications in the postoperative period and the patient reported no symptoms of sinusitis after two months of follow-up. We experience unexpected events in the course of treating a displaced implant into the maxillary sinus. Our case report may provide several learning points for the removal of a missing implant.

DOI： 10.7759/cureus.63243

Double-faced CX3CL1 enhances lymphangiogenesis-dependent metastasis in an aggressive subclone of oral squamous cell carcinoma. International journal

Htoo Shwe Eain, Hotaka Kawai, Masaaki Nakayama, May Wathone Oo, Toshiaki Ohara, Yoko Fukuhara, Kiyofumi Takabatake, Quisheng Shan, Yamin Soe, Kisho Ono, Keisuke Nakano, Nobuyoshi Mizukawa, Seiji Iida, Hitoshi Nagatsuka

JCI insight 9 ( 10 ) 2024.5

Language：English Publishing type：Research paper (scientific journal)

Because cancer cells have a genetically unstable nature, they give rise to genetically different variant subclones inside a single tumor. Understanding cancer heterogeneity and subclone characteristics is crucial for developing more efficacious therapies. Oral squamous cell carcinoma (OSCC) is characterized by high heterogeneity and plasticity. On the other hand, CX3C motif ligand 1 (CX3CL1) is a double-faced chemokine with anti- and pro-tumor functions. Our study reported that CX3CL1 functioned differently in tumors with different cancer phenotypes, both in vivo and in vitro. Mouse OSCC 1 (MOC1) and MOC2 cells responded similarly to CX3CL1 in vitro. However, in vivo, CX3CL1 increased keratinization in indolent MOC1 cancer, while CX3CL1 promoted cervical lymphatic metastasis in aggressive MOC2 cancer. These outcomes were due to double-faced CX3CL1 effects on different immune microenvironments indolent and aggressive cancer created. Furthermore, we established that CX3CL1 promoted cancer metastasis via the lymphatic pathway by stimulating lymphangiogenesis and transendothelial migration of lymph-circulating tumor cells. CX3CL1 enrichment in lymphatic metastasis tissues was observed in aggressive murine and human cell lines. OSCC patient samples with CX3CL1 enrichment exhibited a strong correlation with lower overall survival rates and higher recurrence and distant metastasis rates. In conclusion, CX3CL1 is a pivotal factor that stimulates the metastasis of aggressive cancer subclones within the heterogeneous tumors to metastasize, and our study demonstrates the prognostic value of CX3CL1 enrichment in long-term monitoring in OSCC.

DOI： 10.1172/jci.insight.174618

当科における口唇口蓋裂症例に対する上顎骨骨延長術の応用

有村友紀, 天野克比古, 中辻和樹, 永田裕樹, 加藤壮真, 植田紘貴, 上岡寛, 飯田征二

日本顎変形症学会雑誌 34 ( 2 ) 136 - 136 2024.5

術前後にナゾメーターで鼻咽腔閉鎖機能を評価し上顎骨延長術により反対咬合の改善を行った口蓋裂症例の一例

植田紘貴, 岡直毅, 中西泰之, 有村友紀, 飯田征二, 上岡寛

日本顎変形症学会雑誌 34 ( 2 ) 137 - 137 2024.5

4切歯を含む上顎歯槽骨切り術によって歯列不正を改善した2症例

中辻和樹, 天野克比古, 谷本裕子, 河野加奈, 有村友紀, 永田裕樹, 加藤壮真, 上岡寛, 飯田征二

日本顎変形症学会雑誌 34 ( 2 ) 191 - 191 2024.5

Sturge-Weber syndrome with cemento-ossifying fibroma in the maxilla and giant odontoma in the mandible: A case report

Aki Sato, Hisako Furusho, Tatsushi Matsumura, Makoto Nakano, Koichi Sawaki, Yohsuke Yoshioka, Sho Akashi, Mutsumi Miyauchi, Nobuyoshi Mizukawa, Seiji Iida

Heliyon 10 ( 8 ) e29445 - e29445 2024.4

重度開口障害により口蓋裂未手術のロバン・シークエンス症例で栓塞子を併用して矯正歯科治療を行った一例 Reviewed

穴田理嵯, 植田紘貴, 古西隆之, 中川敦子, 有村友紀, 飯田征二, 上岡寛

日本口蓋裂学会雑誌 49 ( 2 ) 154 - 154 2024.4

光学印象で前方骨片の可動性に配慮し無圧印象することで上顎骨前方部骨延長(MASDO)術後の安定を図った一例 Reviewed

竹本史子, 植田紘貴, 中西泰之, 西谷悠希, 兵藤藍子, 有村友紀, 飯田征二, 上岡寛

日本口蓋裂学会雑誌 49 ( 2 ) 153 - 153 2024.4

扇型の上顎骨拡大により正常被蓋を獲得した片側性唇顎口蓋裂の3症例

西谷悠希, 有村友紀, 天野克比古, 兵藤藍子, 植田紘貴, 河野加奈, 大久保香織, 竹本史子, 上岡寛, 飯田征二

日本口蓋裂学会雑誌 49 ( 2 ) 161 - 161 2024.4

放射線性顎骨壊死18例における感染源と周術期口腔管理の効果についての検討

武田斉子, 水川展吉, 田村庄平, 中田靖章, 天野克比古, 浅海淳一, 飯田征二

岡山歯学会雑誌 42 ( 2 ) 23 - 32 2023.12

Language：Japanese Publisher：岡山歯学会

当科で治療を行った放射線性顎骨壊死(ORN)について、発症原因となった歯科疾患を中心に検討し、周術期口腔管理の有無による臨床像の違いも評価した。2013～2021年にORNと診断された18例(男性12例、女性6例)を対象とした。口腔管理群8例では感染源が歯周炎に関わる症例はなく、智歯周囲炎3例、咬合性外傷4例、感染源不明1例であった。非管理群10例では辺緑性歯周炎2例、根尖性歯周炎が3例、智歯周囲炎2例、義歯性潰瘍1例、感染源不明2例であった。保存療法のみ行ったのは8例であり、保存療法を行ったものの悪化を認めたため高気圧酸素療法を行ったのは3例、最終的に外科治療を行ったのは7例であった。ORNの予後や各治療方法の効果においては管理群と非管理群で明らかな違いはなかった。

充実部と嚢胞部が混在し診断に苦慮したエナメル上皮腫の1例

舩橋洋志, 天野克比古, 岩本悠希, 長尾有里, 高畠清文, 永田裕樹, 飯田征二

日本口腔科学会雑誌 72 ( 4 ) 258 - 258 2023.12

歯磨剤が含有するSLSに起因したと考えられた口腔粘膜剥離の1例

西谷悠希, 天野克比古, 武田斉子, 有村友紀, 田村庄平, 中辻和樹, 永田裕樹, 飯田征二

岡山歯学会雑誌 42 ( 2 ) 69 - 69 2023.12

左側下顎頭内側に周辺性骨腫を有する顔面非対称患者に骨腫切除と外科的矯正治療を行った1例

河野加奈, 竹本史子, 太田明美, 森谷徳文, 飯田征二, 上岡寛

日本矯正歯科学会大会プログラム・抄録集 82回 257 - 257 2023.11

A case of sublingual dermoid cyst treated by trans oral marspialization Reviewed

Takeda S, Tamura S, Amano K, Mizukawa T, Takabatake K, Iida S

69 ( 10 ) 475 - 480 2023.10

Expression and function of CCN2-derived circRNAs in chondrocytes

Soma Kato, Kazumi Kawata, Takashi Nishida, Tomomi Mizukawa, Masaharu Takigawa, Seiji Iida, Satoshi Kubota

Journal of Cell Communication and Signaling 2023.9

Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Cellular communication network factor 2 (CCN2) molecules promote endochondral ossification and articular cartilage regeneration, and circular RNAs (circRNAs), which arise from various genes and regulate gene expression by adsorbing miRNAs, are known to be synthesized from CCN2 in human vascular endothelial cells and other types of cells. However, in chondrocytes, not only the function but also the presence of CCN2-derived circRNA remains completely unknown. In the present study, we investigated the expression and function of CCN2-derived circRNAs in chondrocytes. Amplicons smaller than those from known CCN2-derived circRNAs were observed using RT-PCR analysis that could specifically amplify CCN2-derived circRNAs in human chondrocytic HCS-2/8 cells. The nucleotide sequences of the PCR products indicated novel circRNAs in the HCS-2/8 cells that were different from known CCN2-derived circRNAs. Moreover, the expression of several Ccn2-derived circRNAs in murine chondroblastic ATDC5 cells was confirmed and observed to change alongside chondrocytic differentiation. Next, one of these circRNAs was knocked down in HCS-2/8 cells to investigate the function of the human CCN2-derived circRNA. As a result, CCN2-derived circRNA knockdown significantly reduced the expression of aggrecan mRNA and proteoglycan synthesis. Our data suggest that CCN2-derived circRNAs are expressed in chondrocytes and play a role in chondrogenic differentiation.

Graphical abstract

DOI： 10.1007/s12079-023-00782-7

Other Link： https://link.springer.com/article/10.1007/s12079-023-00782-7/fulltext.html

A case of epidermoid cyst considered as originated from the abdominal skin tissue inserted into the temporomandibular joint 52 years ago

Soma Kato, Katsuhiko Amano, Norifumi Moritani, Yuki Nagata, Natsuki Segami, Seiji Iida

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 2023.8

骨性癒着が疑われた上顎中切歯を有する上顎前突症例に対する外科的矯正治療 4前歯での上顎前歯部歯槽骨切り術

谷本裕子, 森谷徳文, 松村達志, 有村友紀, 近藤星, 飯田征二

中・四国矯正歯科学会雑誌 35 ( 1 ) 51 - 66 2023.8

Language：Japanese Publisher：中・四国矯正歯科学会

今回,上顎4前歯部の歯槽骨切り術を施術した上顎前突症例について報告する.患者は初診時年齢15歳3ヵ月の男子で,上顎前歯の突出を主訴として来院した.12歳時に上顎右側中切歯の打撲の既往があった.側面観は凸型で,口唇の突出および頤筋の緊張感を認めた.∠SNAは81.9°,∠SNBは73.5°,∠ANBは8.4°で骨格性II級を呈していた.上顎前歯は著しく唇側傾斜し,オーバージェットは14.0mm,オーバーバイトは4.0mmで,大臼歯関係および犬歯関係は両側ともにアングルII級を呈していた.上顎右側第一小臼歯と下顎右側第二小臼歯は交叉咬合であった.上顎両側第一小臼歯の片顎抜去による治療方針とし治療を開始したが,動的治療開始10ヵ月後の犬歯牽引中に上顎右側中切歯の骨性癒着が疑われた.治療計画を矯正歯科治療単独から,犬歯牽引後に上顎4前歯を上顎前歯部歯槽骨切り術にて後方移動する方針に変更した.術前矯正治療を1年11ヵ月行った後に上顎前歯部歯槽骨切り術を施術した.術後矯正治療1年5ヵ月後に動的治療を終了し保定に移行した.∠SNAは80.8°,∠SNBは73.7°,∠ANBは7.1°になり,上顎前歯は標準的傾斜となり,オーバージェットは2.6mm,オーバーバイトは3.5mmに改善された.上顎4前歯部の歯槽骨切り術により上顎前歯部は後退し,凸型の側貌と口唇閉鎖不全は改善し良好な側貌が得られた.保定開始後2年3ヵ月経過時においても,良好な顔貌と咬合は維持されている.(著者抄録)

副甲状腺ホルモン受容体シグナルはマウス鼻軟骨の形成に必須である

天野克比古, 北岡好大, 栗岡恭子, 田中晋, 飯田征二

日本口腔科学会雑誌 72 ( 2 ) 151 - 151 2023.7

下顎頭内側に周辺性骨腫を有する顔面非対称患者に外科的矯正治療を行った1例

河野加奈, 竹本史子, 太田明美, 森谷徳文, 加藤壮真, 飯田征二, 上岡寛

日本顎変形症学会雑誌 33 ( 2 ) 207 - 207 2023.5

頭蓋顔面の発育を制御する頭蓋底軟骨におけるヘッジホッグシグナル受容性の違いと特徴

天野克比古, 加藤壮真, 飯田征二

日本顎変形症学会雑誌 33 ( 2 ) 223 - 223 2023.5

Quality of life after tongue cancer treatment and its influencing factors: A cross‐sectional study of Japanese patients

Hisako Sasahara, Yuko Kurawaki, Kenichiro Uchida, Tatsushi Matsumura, Hideo Shigeishi, Yasutaka Hayashido, Shigeaki Toratani, Seiji Iida, Katsuaki Mishima, Kouji Ohta, Masaru Sugiyama

Oral Science International 2023.4

口腔支持療法により外来放射線治療を完遂できた口腔癌3症例

武田斉子, 有村友紀, 田村庄平, 中辻和樹, 三上彩可, 松崎秀信, 丸山貴之, 横井彩, 天野克比古, 水川展吉, 飯田征二

日本口腔ケア学会雑誌 17 ( 3 ) 242 - 242 2023.4

Treatment of Severe Open Bite Malocclusion with Four-Piece Segmental Horseshoe Le Fort I Osteotomy.

Mitsuhiro Hoshijima, Naoki Oka, Tatsushi Matsumura, Seiji Iida, Hiroshi Kamioka

Acta medica Okayama 77 ( 1 ) 97 - 104 2023.2

Language：English

Appropriate operations in severe anterior open bite (AOB) cases are extremely complicated to perform because of the multiple surgical procedures involved, the difficulty of predicting posttreatment aesthetics, and the high relapse rate. We herein report a 16-year-old girl with skeletal Class II, severe AOB malocclusion, and crowding with short roots, and aesthetic and functional problems. Four-piece segmental Le Fort I osteotomy with horseshoe osteotomy was performed for maxillary intrusion, and bilateral sagittal split ramus osteotomy (SSRO) and genioplasty were performed for mandibular advancement. The malocclusion and skeletal deformity were significantly improved by the surgical orthodontic treatment. Functional and aesthetic occlusion with an improved facial profile was established, and no further root shortening was observed. Acceptable occlusion and dentition were maintained after a two-year retention period. This strategy of surgical orthodontic treatment with a complicated operative procedure might be effective for correcting certain severe AOB malocclusion cases.

DOI： 10.18926/AMO/64369

Osteonecrosis of the Jaw in Two Rheumatoid Arthritis Patients Not Treated with a Bisphosphonate

Katsuhiko Amano, Akinari Sugauchi, Chiaki Yamada, Mikihiko Kogo, Seiji Iida

ACTA MEDICA OKAYAMA 77 ( 1 ) 111 - 116 2023.2

Language：English Publishing type：Research paper (scientific journal) Publisher：OKAYAMA UNIV MED SCHOOL

Medication-related osteonecrosis of the jaw (MRONJ) is a side effect in patients taking bone-modifying agents (BMAs), which are highly beneficial for treating osteoporosis and cancer. Bisphosphonates are prescribed to treat secondary osteoporosis in patients with rheumatoid arthritis (RA). We recently encountered two unusual cases of intraoral ONJ in RA patients who had not been treated with a BMA and did not have features of methotrexate-associated lymphoproliferative disorder. Their ONJ stage II bone exposures were treated by conservative therapy, providing good prognoses. These cases indicate that ONJ can occur in RA patients not treated with bisphosphonates. Several risk factors are discussed.

上顎骨病変

古庄寿子, 佐藤亜希, 松村達志, 中野誠, 澤木康一, 吉岡洋祐, 明石翔, 水川展吉, 飯田征二, 柿本直也, 宮内睦美

日本口腔診断学会雑誌 36 ( 1 ) 48 - 48 2023.2

Mandibular condylar displacement and the associated factors following intraoral vertical ramus osteotomy

Yuki Nagata, Norifumi Moritani, Katsuhiko Amano, Yuki Arimura, Kazuki Nakatsuji, Soma Kato, Ayaka Mikami, Tatsushi Matsumura, Seiji Iida

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 35 ( 5 ) 390 - 396 2023.1

QUAD shotによる緩和的放射線治療を適用した終末期口腔癌の1例

兵頭誠治, 加藤祐季, 加藤昌, 武田斉子, 水川展吉, 飯田征二

日本口腔外科学会雑誌 69 ( 1 ) 9 - 14 2023.1

Language：Japanese Publisher：(公社)日本口腔外科学会

79歳男性。既往として40年前に右下顎歯肉癌に対し手術と放射線治療が行われていた。今回、右下顎部の疼痛ならびに開口障害を主訴に、近在の歯科医院より精査目的で当科へ紹介となった。画像所見、生検結果を踏まえて、右下顎歯肉癌の再発と診断され、患者の全身状態、希望よりQUAD shotによる緩和的放射線治療が行われた。その結果、QUAD shotとの併用放射線増感剤にPTXを選択し、1コース終了時より腫瘍は縮小し、疼痛の改善傾向がみられた。更に3コース終了後にはオピオイドを中止し、NSAIDsのみで日常生活を過ごせるようになり、摂食機能の改善で食事量の増加から体重減少や低栄養が改善された。最終的には患者はQOLを維持したまま最期を迎えることができた。

Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J01073&link_issn=&doc_id=20230201450002&doc_link_id=10.5794%2Fjjoms.69.9&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.69.9&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

上顎骨病変

古庄寿子, 佐藤亜希, 松村達志, 中野誠, 澤木康一, 吉岡洋祐, 明石翔, 水川展吉, 飯田征二, 柿本直也, 宮内睦美

日本口腔内科学会雑誌 28 ( 2 ) 72 - 72 2022.12

口唇裂・口蓋裂児に関する臨床統計的検討(2019)

高木律男, 児玉泰光, 飯田征二, 井上直子, 小林眞司, 阪井丘芳, 須佐美隆史, 須田直人, 中村典史, 宮脇剛司, 古郷幹彦

日本口蓋裂学会雑誌 47 ( 3 ) 210 - 219 2022.10

Language：Japanese Publisher：(一社)日本口蓋裂学会

一社・日本口蓋裂学会では,学術調査委員会の2020年度の事業として,2019年1年間の会員施設における新規患者について臨床的検討を行った。49施設より965例の登録があり,以下の結果を得た。1)症型別では辰裂110例(11.4%),唇顎裂206例(21.3%),唇顎口蓋裂388例(40.2%),口蓋裂193例(20.0%),粘膜下口蓋裂52例(5.4%),その他16例(1.7%)であった。2)罹患側では左側368例(52.2%),右側183例(26.0%),両側性160例(22.7%)。両側性は唇裂で少なく,唇顎口蓋裂で他の症型に比べて多かった。3)性別では女性432例(44.8%),男性533例(55.2%)。多くの症型で男性が多い中,口蓋裂では若干であるが,女性の方が多かった。4)出生時体重では,粘膜下口蓋裂で他の症型よりも低体重であった。5)出生前診断では,外表に変化のある口唇裂を含む症型で50%程度であった。6)両親の年齢では,全体に父親が母親よりも若干高年齢であったが症型間に差はなかった。7)血族内での出生では,いずれの症型も6～8%をしめていた。8)併発疾患および9)症候群,染色体異常については,口蓋裂および粘膜下口蓋裂児において頻度が高かった。併発疾患については,1例で複数の併発がみられる場合が多かった。なお,症型間で統計処理(カイ二乗検定)を行い,性差,罹患側,生下時体重,併発疾患,症候群・染色体異常において有意差(p<0.05)を認めた。以上,1年間に出生した日本人の口唇裂・口蓋裂児の多数例の検討から有意義なデータが得られた。(著者抄録)

Other Link： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J01071&link_issn=&doc_id=20221208300004&doc_link_id=10.11224%2Fcleftpalate.47.210&url=https%3A%2F%2Fdoi.org%2F10.11224%2Fcleftpalate.47.210&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Attempt of thyX gene silencing and construction of a thyX deleted clone in a Mycobacterium bovis BCG

Yuki Arimura, Yusuke Minato, Takayuki Wada, Masaaki Nakayama, Ayako Ryumon, Nao Hirata, Chie Nakajima, Yasuhiko Suzuki, Manabu Ato, Kazuo Kobayashi, Naoko Ohara, Seiji Iida, Naoya Ohara

Microbiology and Immunology 66 ( 1 ) 10 - 14 2022.1

Comparing the Osteogenic Potential and Bone Regeneration Capacities of Dedifferentiated Fat Cells and Adipose-Derived Stem Cells In Vitro and In Vivo: Application of DFAT Cells Isolated by a Mesh Method. International journal

Kiyofumi Takabatake, Masakazu Matsubara, Eiki Yamachika, Yuki Fujita, Yuki Arimura, Kazuki Nakatsuji, Keisuke Nakano, Histoshi Nagatsuka, Seiji Iida

International journal of molecular sciences 22 ( 22 ) 2021.11

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: We investigated and compared the osteogenic potential and bone regeneration capacities of dedifferentiated fat cells (DFAT cells) and adipose-derived stem cells (ASCs). METHOD: We isolated DFAT cells and ASCs from GFP mice. DFAT cells were established by a new culture method using a mesh culture instead of a ceiling culture. The isolated DFAT cells and ASCs were incubated in osteogenic medium, then alizarin red staining, alkaline phosphatase (ALP) assays, and RT-PCR (for RUNX2, osteopontin, DLX5, osterix, and osteocalcin) were performed to evaluate the osteoblastic differentiation ability of both cell types in vitro. In vivo, the DFAT cells and ASCs were incubated in osteogenic medium for four weeks and seeded on collagen composite scaffolds, then implanted subcutaneously into the backs of mice. We then performed hematoxylin and eosin staining and immunostaining for GFP and osteocalcin. RESULTS: The alizarin red-stained areas in DFAT cells showed weak calcification ability at two weeks, but high calcification ability at three weeks, similar to ASCs. The ALP levels of ASCs increased earlier than in DFAT cells and showed a significant difference (p < 0.05) at 6 and 9 days. The ALP levels of DFATs were higher than those of ASCs after 12 days. The expression levels of osteoblast marker genes (osterix and osteocalcin) of DFAT cells and ASCs were higher after osteogenic differentiation culture. CONCLUSION: DFAT cells are easily isolated from a small amount of adipose tissue and are readily expanded with high purity; thus, DFAT cells are applicable to many tissue-engineering strategies and cell-based therapies.

DOI： 10.3390/ijms222212392

Camouflage Treatment for Skeletal Maxillary Protrusion and Lateral Deviation with Classic-Type Ehlers-Danlos Syndrome.

Mitsuhiro Hoshijima, Noriaki Kawanabe, Seiji Iida, Takashi Yamashiro, Hiroshi Kamioka

Acta medica Okayama 75 ( 2 ) 205 - 212 2021.4

Language：English

We herein report the case of a 19-year-old female with a transverse discrepancy, skeletal Class II malocclusion, severe crowding with concerns of classic-type Ehlers-Danlos syndrome (EDS), aesthetics problems and functional problems. The main characteristics of classic EDS are loose-jointedness and fragile, easily bruised skin that heals with peculiar "cigarette-paper" scars. The anteroposterior and transverse skeletal discrepancies can generally be resolved by maxilla repositioning and mandibular advancement surgery following pre-surgical orthodontic treatment. However, this patient was treated with orthodontic camouflage but not orthognathic surgery because of the risks of skin bruising, poor healing and a temporomandibular disorder. A satisfactory dental appearance and occlusion were achieved after camouflage treatment with orthodontic anchor screws and the use of Class II elastics, including the preservation of the stomatognathic functions. Acceptable occlusion and dentition were maintained after a two-year retention period. This treatment strategy of orthodontic camouflage using temporary anchorage, such as anchor screws and Class II elastics, may be a viable treatment option for skeletal malocclusion patients with EDS.

DOI： 10.18926/AMO/61902

Regulation of cellular communication network factor 2 (CCN2) in breast cancer cells via the cell-type dependent interplay between CCN2 and glycolysis. International journal

Sho Akashi, Takashi Nishida, Tomomi Mizukawa, Kazumi Kawata, Masaharu Takigawa, Seiji Iida, Satoshi Kubota

Journal of oral biosciences 62 ( 3 ) 280 - 288 2020.9

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: Anti-osteoclastic treatments for breast cancer occasionally cause medication-related osteonecrosis of the jaw. Moreover, elevated glycolytic activity, which is known as the Warburg effect, is usually observed in these breast cancer cells. Previously, we found that cellular communication network factor 2 (CCN2) production and glycolysis enhanced each other in chondrocytes. Here, we evaluated the interplay between CCN2 and glycolysis in breast cancer cells, as we suspected a possible involvement of CCN2 in the Warburg effect in highly invasive breast cancer cells. METHODS: Two human breast cancer cell lines with a distinct phenotype were used. Glycolysis was inhibited by using 2 distinct compounds, and gene silencing was performed using siRNA. Glycolysis and the expression of relevant genes were monitored via colorimetric assays and quantitative RT-PCR, respectively. RESULTS: Although CCN2 expression was almost completely silenced when treating invasive breast cancer cells with a siRNA cocktail against CCN2, glycolytic activity was not affected. Notably, the expression of glycolytic enzyme genes, which was repressed by CCN2 deficiency in chondrocytes, tended to increase upon CCN2 silencing in breast cancer cells. Inhibition of glycolysis, which resulted in the repression of CCN2 expression in chondrocytic cells, did not alter or strongly enhanced CCN2 expression in the invasive and non-invasive breast cancer cells, respectively. CONCLUSIONS: High CCN2 expression levels play a critical role in the invasion and metastasis of breast cancer. Thus, a collapse in the intrinsic repressive machinery of CCN2 due to glycolysis may induce the acquisition of an invasive phenotype in breast cancer cells.

DOI： 10.1016/j.job.2020.07.001

片側性唇顎口蓋裂を伴ったt(11;22)(q23.3;q11.2)均衡型相互転座の1例

有村友紀, 山田智明, 岡田亜由美, 薬師寺翔太, 岡本成美, 飯田征二

日本口腔外科学会雑誌 66 ( 8 ) 406 - 410 2020.8

Language：Japanese Publisher：(公社)日本口腔外科学会

症例は3ヵ月男児で、左側唇口蓋裂を認め、出生後早期の染色体G-banding検査にて46,XY,t(11;22)(q23.3;q11.2)と診断された。口蓋裂一貫治療目的に当科を紹介受診した。初診時にホッツ床作製のための印象採得を行い、生後3ヵ月からホッツ床による顎誘導ならびに哺乳の改善を行った。生後5ヵ月目に全身麻酔下にて口唇形成術を施行し、口蓋裂に対しては2段階による口蓋形成術を行うものとし、初回は1歳3ヵ月時に軟口蓋形成術(Furlow法)を行い、1歳11ヵ月で2回目となる硬口蓋閉鎖術を施行した。術後経過は良好であり、2歳2ヵ月から言語聴覚士による発達検査、言語治療を開始した。鼻咽腔閉鎖機能不全や構音障害はみられず、定期的な経過観察を行っている。現在5歳8ヵ月で反対咬合を認めている。

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J01073&link_issn=&doc_id=20200828330010&doc_link_id=130007928053&url=https%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F130007928053&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

Epidemiological Correlations Between Head and Neck Cancer and Hepatitis B Core Antibody Positivity. International journal

Mai Fukushima Komori, Takuji Kimura, Shin Kariya, Tomoo Onoda, Seiko Takeda, Nobuyoshi Mizukawa, Seiji Iida, Yoshihiro Kimata, Kazunori Nishizaki

Anticancer research 40 ( 4 ) 2393 - 2403 2020.4

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND/AIM: Hepatitis B core (HBc) antibody positivity indicates a history of hepatitis B virus (HBV) infection and latent infection. PATIENTS AND METHODS: We conducted a retrospective case-control study of 512 and 495 head and neck cancer (HNC) and non-HNC patients treated at the Okayama University Hospital, Head and Neck Cancer Center from 2008-2017. Demographic data and risk factors that might affect HNC diagnosis were analyzed to assess their effects. RESULTS: Cancer diagnosis was found to correlate with HBc antibody positivity [odds ratio (OR)=1.50, 95% confidence interval (CI)=1.09-2.08], smoking (OR=3.03, 95%CI=2.16-4.25), and a previous history of cancer (OR=4.12, 95%CI=2.79-6.09). The HBs antigen positivity rate in both groups was very close to that observed in the general Japanese population. The HBc antibody positivity rate was very high only in the HNC group. CONCLUSION: HBc antibody positivity and HNC are epidemiologically correlated.

DOI： 10.21873/anticanres.14209

The Elimination of Dental Crowding and Development of a Proper Dental Arch by Maxillary Anterior Segmental Distraction Osteogenesis for a Patient With UCLP. Reviewed International journal

Chihiro Tanikawa, Donghoon Lee, Yuri Yamamoto Oonishi, Seiji Haraguchi, Tomonao Aikawa, Mikihiko Kogo, Seiji Iida, Takashi Yamashiro

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 56 ( 7 ) 978 - 985 2019.8

Language：English

OBJECTIVE: This report describes the case of a male patient with a complete unilateral cleft lip and palate who presented with midface deficiency and an anteroposteriorly constricted maxilla. DESIGN: Case report Interventions: Correction involved anterior distraction of the segmented maxilla. RESULTS: The present case demonstrates that elongation of the maxilla with anterior distraction is an effective way to develop a proper dental arch, correct anterior and posterior crowding, and improve a midface deficiency.

DOI： 10.1177/1055665618821831

スメグマ菌におけるメチオニン関連遺伝子欠損株作製とその解析

橋本和樹, 飯田征二, 大原直也

岡山歯学会雑誌 38 ( 1 ) 1 - 14 2019.6

Intermittent parathyroid hormone 1–34 induces oxidation and deterioration of mineral and collagen quality in newly formed mandibular bone International journal

Yohsuke Yoshioka, Eiki Yamachika, Makoto Nakanishi, Tadashi Ninomiya, Sho Akashi, Sei Kondo, Norifumi Moritani, Yasuhiro Kobayashi, Tatsuo Fujii, Seiji Iida

Scientific Reports 9 ( 1 ) 8041 - 8041 2019.5

Authorship：Last author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Intermittent parathyroid hormone (PTH) administration is known to promote bone healing after surgical procedures. However, the mechanism and influence of PTH on the mineral and collagen quality of the jaw are not well understood. Most studies have focused on analyzing the bone density and microstructure of the mandible, and have insufficiently investigated its mineral and collagen quality. Oxidative stress activates osteoclasts, produces advanced glycation end products, and worsens mineral and collagen quality. We hypothesized that PTH induces oxidation and affects the mineral and collagen quality of newly formed mandibular bone. To test this, we examined the mineral and collagen quality of newly formed mandibular bone in rats administered PTH, and analyzed serum after intermittent PTH administration to examine the degree of oxidation. PTH administration reduced mineralization and worsened mineral and collagen quality in newly formed bone. In addition, total anti-oxidant capacity in serum was significantly decreased and the oxidative-INDEX was increased among PTH-treated compared to vehicle-treated rats, indicating serum oxidation. In conclusion, intermittent administration of PTH reduced mineral and collagen quality in newly formed mandibular bone. This effect may have been induced by oxidation.

DOI： 10.1038/s41598-019-44389-8

Other Link： https://www.nature.com/articles/s41598-019-44389-8

人工呼吸管理中に浮腫による巨舌を呈した1例

人工呼吸管理中に浮腫による巨舌を呈した, 石邊紀章, 澤木康一, 藤田祐貴, 岡崎文彦, 佐藤亜希, 吉岡洋祐, 中野誠, 松村達志, 山近英樹, 飯田征二

広島市立広島市民病院医誌 35 ( 1 ) 65 - 68 2019.3

Surgical Orthodontic Correction of a Skeletal Class Ⅲ Case Treated by Dental Decompensation Using Anchor Screws Reviewed

TOMOYO TANAKA, TAKASHI MURAKAMI, NORIFUMI MORITANI, TATSUSHI MATSUMURA, SEIJI IIDA, HIROSHI KAMIOKA

The Japanese Journal of Jaw Deformities 29 ( 4 ) 295 - 303 2019

二卵性双生児にみられた22q11.2欠失症候群

有村友紀, 松村達志, 水谷雅英, 植松彩, 松井裕一, 岡田亜由美, 田畑光康, 明石翔, 中川敦子, 飯田征二

岡山歯学会雑誌 37 ( 2 ) 37 - 42 2018.12

Language：Japanese Publisher：岡山歯学会

二卵性双生児で、一人は粘膜下口蓋裂、一人は先天性鼻咽腔閉鎖不全症を伴った22q11.2欠失症候群の症例を報告した。二卵性双生児の兄:5歳時に鼻咽腔閉鎖不全を指摘され、当院耳鼻咽喉科に紹介となった。特異的顔貌を認めたため、染色体検査を行い22q11.2欠失症候群と診断された。粘膜下口蓋裂に対して口蓋形成術(Furlow法)を施行し、その後は定期的に言語訓練を行うこととなった。二卵性双生児の弟:5歳時に鼻咽腔閉鎖不全を指摘され、兄とともに当院耳鼻咽喉科に紹介となった。軟口蓋挙上装置を装着し、言語訓練を行った。一旦来院が途絶えていたが再来院され、言語訓練の重要性を十分に説明した。その後は定期的に言語訓練を施行している。

A3 adenosine receptor agonist attenuates neuropathic pain by suppressing activation of microglia and convergence of nociceptive inputs in the spinal dorsal horn Reviewed

Ryuji Terayama, Mitsuyasu Tabata, Kotaro Maruhama, Seiji Iida

Experimental Brain Research 236 ( 12 ) 3203 - 3213 2018.12

Dental management of unilateral multiple impacted primary teeth

Yuki Matsumi, Yuko Morikawa, Eri Yoshida, Setsuyo Morimoto, Sho Yoshida, Tatsushi Matsumura, Seiji Iida, Yukiko Takashima, Shuhei Naka, Michiyo Matsumoto-Nakano

PEDIATRIC DENTAL JOURNAL 28 ( 3 ) 119 - 124 2018.12

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE BV

Impacted primary teeth can be caused by odontogenic tumors such as odontomas, cystic diseases such as dentigerous and eruption cysts, and fibrous hyperplasia of the gingiva, while elimination of those causes reportedly results in normal eruption of primary teeth. We describe the course of a child from the age of 1 year until 4 years 10 months who had primary tooth eruption failure and was treated with dental methods. Although primary teeth expected to spontaneously erupt were followed, there were several on the left side that remained unerupted. We performed a left maxillary and mandibular gingivectomy to closely examine the cause of eruption delay and tooth germ dislocation, as well as attempt to induce eruption of the primary teeth. Based on histopathological results, the diagnosis was fibroma. Surgical procedures did not result in clear improvement of eruption failure. In order to improve masticatory function and aesthetics, the child was fixed with an artificial denture for all primary teeth not expected to erupt. (C) 2018 Japanese Society of Pediatric Dentistry. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.pdj.2018.09.002

Efficacy of Maxillary Anterior Segmental Distraction Osteogenesis in Patients With Cleft Lip and Palate. Reviewed International journal

Chihiro Tanikawa, Kae Hirata, Tomonao Aikawa, Jun Maeda, Mikihiko Kogo, Seiji Iida, Takashi Yamashiro

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 55 ( 10 ) 1375 - 1381 2018.11

Language：English

OBJECTIVES: To evaluate the effects of maxillary anterior segmental distraction osteogenesis (MASDO) in patients with cleft lip and palate (CLP) and to identify risk factors for increased relapse. DESIGN: A retrospective study. PATIENTS: Thirty-one Japanese patients with CLP who underwent MASDO were eligible for study inclusion. MAIN OUTCOME MEASURES: We evaluated lateral cephalograms obtained before (T1), at 3 months (T2), and at 1 year (T3) after MASDO, and measured changes from T1 to T2 (δT1T2), from T2 to T3 (δT2T3), and from T1 to T3 (δT1T3). We also evaluated the risk factors associated with an increased relapse. RESULTS: Overall (δT1T3), MASDO improved retrusion of the maxilla. We measured a significant advancement (6.1 mm) of the anterior maxillary segment in δT1T2 (A-McNamara classification) and increases in the overjet and the SNA, ANB, and nasolabial angles. However, skeletal relapse was evident in δT2T3, and the median percentage of relapse was 10%. To explore the risk factors, we subdivided patients with a δT1T2 of >5 mm into 2 groups based on the percentage of relapse (>15% vs ≤15%). There were significant differences between these groups in the vertical positions of the anterior nasal spine and point A, and the angle formed by the SN and palatal planes (SNPP), suggestive of intraoperative counterclockwise rotation of the maxilla. CONCLUSIONS: MASDO is effective for correcting midfacial deficiencies, but counterclockwise rotation of the maxilla during surgery may cause relapse.

DOI： 10.1177/1055665618758692

Cathepsin K inhibitor causes changes in crystallinity and crystal structure of newly-formed mandibular bone in rats

Y. Yoshioka, E. Yamachika, M. Nakanishi, T. Ninomiya, K. Nakatsuji, Y. Kobayashi, T. Fujii, S. Iida

British Journal of Oral and Maxillofacial Surgery 56 ( 8 ) 732 - 738 2018.10

Molecular alterations of newly formed mandibular bone caused by zoledronate

Y. Yoshioka, E. Yamachika, M. Nakanishi, T. Ninomiya, K. Nakatsuji, M. Matsubara, N. Moritani, Y. Kobayashi, T. Fujii, S. Iida

International Journal of Oral and Maxillofacial Surgery 47 ( 9 ) 1206 - 1213 2018.9

Peripheral neuropathy arose in the trigeminal nerve during chemotherapy with docetaxel: A report of two cases

Yuki Fujita, Shunsuke Hino, Koichi Sawaki, Makoto Nakano, Takahiro Kaneko, Norio Horie, Seiji Iida

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 30 ( 4 ) 359 - 364 2018.7

PTH間歇投与による下顎新生骨の骨質変化ラマン分光法を用いた骨質解析

吉岡洋祐, 山近英樹, 中西真, 二宮禎, 明石翔, 松原正和, 森谷徳文, 小林泰浩, 藤井達生, 飯田征二

日本骨形態計測学会雑誌 28 ( 2 ) S109 - S109 2018.5

Odontoma associated with unerupted primary tooth in primary dentition - Three cases

Yukiko Takashima, Yuko Morikawa, Atsushi Takagi, Yuki Matsumi, Tatsushi Matsumura, Seiji Iida, Shuhei Naka, Michiyo Matsumoto-Nakano

PEDIATRIC DENTAL JOURNAL 28 ( 1 ) 19 - 24 2018.4

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE BV

Odontomas are generally encountered in permanent dentition and rarely seen in primary dentition. These lesions are regarded as essentially benign, though they often cause disturbances in eruption of the associated tooth. We present clinical findings and management of 3 cases of odontomas that occurred in primary dentition, including a 3-year-old girl referred for examination of an unerupted left upper primary canine, a 6-year-old boy with an unerupted left lower second primary molar, and a 5-year-old girl who was presented with an unerupted right upper second primary molar. In all cases, periapical and panoramic radiography revealed a radio-opaque mass surrounded by a narrow radiolucent space located above the crown of the unerupted tooth. Each was diagnosed as a compound odontoma interfering with eruption of a primary tooth and surgical removal was performed under general anesthesia for all patients, with the final diagnosis based on histological findings. Following surgery, the primary canine in Case 1 spontaneously erupted, while a space maintenance appliance was applied in Case 2 and 3. It is important to recognize that an odontoma can appear in primary dentition, though the incidence is quite low. Early detection and removal of an odontoma associated with an impacted primary tooth is necessary for optimal dentition. (C) 2017 Published by Elsevier Ltd on behalf of Japanese Society of Pediatric Dentistry.

DOI： 10.1016/j.pdj.2017.10.001

Differential induction of c-Fos and phosphorylated ERK by a noxious stimulus after peripheral nerve injury

Mitsuyasu Tabata, Ryuji Terayama, Kotaro Maruhama, Seiji Iida, Tomosada Sugimoto

International Journal of Neuroscience 128 ( 3 ) 208 - 218 2018.3

Metabolic regulation of the CCN family genes by glycolysis in chondrocytes. International journal

Sho Akashi, Takashi Nishida, Abdellatif El-Seoudi, Masaharu Takigawa, Seiji Iida, Satoshi Kubota

Journal of cell communication and signaling 12 ( 1 ) 245 - 252 2018.3

Language：English Publishing type：Research paper (scientific journal)

The CCN family consists of 6 genes in the mammalian genome and produces multifunctional proteins involved in a variety of biological processes. Recent reports indicate the profound roles of CCN2 in energy metabolism in chondrocytes, and Ccn2 deficiency is known to alter the expression of 2 other family members including Ccn3. However, almost nothing is known concerning the regulation of the CCN family genes by energy metabolism. In order to gain insight into this critical issue, we initially and comprehensively evaluated the effect of inhibition of glycolysis on the expression of all of the CCN family genes in chondrocytic cells. Upon the inhibition of a glycolytic enzyme, repression of CCN2 expression was observed, whereas CCN3 expression was conversely induced. Similar repression of CCN2 was conferred by the inhibition of aerobic ATP production, which, however, did not induce CCN3 expression. In contrast, glucose starvation significantly enhanced the expression of CCN3 in those cells. The results of a reporter gene assay using a molecular construct containing a CCN3 proximal promoter revealed a dose-dependent induction of the CCN3 promoter activity by the glycolytic inhibitor in chondrocytic cells. These results unveiled a critical role of glycolytic activity in the regulation of CCN2 and CCN3, which activity mediated the mutual regulation of these 2 major CCN family members in chondrocytes.

DOI： 10.1007/s12079-017-0420-8

The influence of zoledronate and teriparatide on gamma delta T cells in mice Reviewed International journal

Yamachika Eiki, Matsui Yuichi, Matsubara Masakazu, Matsumura Tatsushi, Nakata Naoki, Moritani Norifumi, Ikeda Atsushi, Tsujigiwa Hidetsugu, Ohara Naoya, Iida Seiji

JOURNAL OF DENTAL SCIENCES 12 ( 4 ) 333 - 339 2017.12

Language：English Publishing type：Research paper (scientific journal)

Background/purpose: Few studies have investigated the possibility that bisphosphonate-related osteonecrosis of the jaw (BRONJ) might reflect an immune response; however, gamma delta T cells have been shown to significantly decline in the blood of BRONJ patients. Additionally, there have been some reports of teriparatide usage for the treatment of BRONJ. In this study, we compared the effects of zoledronate and teriparatide on lymphocyte populations and inflammatory cytokine production in mice. Materials and methods: Thirty female ICR mice were divided into three groups (n = 10 each): a vehicle, a zoledronate, and a teriparatide group. Drugs were administered for 8 weeks in each group. Lymphocytes in the blood and thymus were analyzed and femurs were used for histological observation and lymphocytes analysis of bone marrow. Cytokines were measured in separated serum using Milliplex® multiplex immunoassay analysis. Results: Zoledronate decreased the T cell number in the bone marrow. Additionally, serum levels of interleukin (IL)-2, IL-7, IL-12, IL-15 and RANTES, which are cytokines that affect T cell activation, differentiation and/or proliferation, were significantly lower in zoledronate treated mice. Conversely, teriparatide treatment induced an increase in gamma delta T cells in peripheral blood. Conclusion: Gamma delta T cells in the bone marrow are expected to decrease with zoledronate treatment and increase with teriparatide treatment. If BRONJ involves a loss of gamma delta T cells in the circulation or bone marrow, then the increase in gamma delta T cells that is induced by teriparatide may account for its ability to resolve BRONJ.

DOI： 10.1016/j.jds.2017.03.007

The Incidence of Oral and Oropharyngeal Cancers in Betel Quid-Chewing Populations in South Myanmar Rural Areas

Nobuyoshi Mizukawa, Swe Swe Win, Zaw Moe Thein, Moe Thida Htwe, Yohsuke Yoshioka, Yoshihiro Kimata, Seiji Iida, Myo Khin, Shigeru Okada, Than Sein

Act Medica OKAYAMA 71 ( 6 ) 519 - 524 2017.12

多数の静脈石を認めた咬筋内静脈奇形の1例

藤田佑貴, 水谷雅英, 有村友紀, 池田篤司, 柳文修, 飯田征二

日本口腔外科学会雑誌 63 ( 11 ) 593 - 597 2017.11

Language：Japanese Publisher：(公社)日本口腔外科学会

症例は21歳女性で、13年前に左側頬部の腫瘤を自覚したが確定診断には至らなかった。左側頬部に鈍痛を覚えるようになり、腫瘤の増大を認めた。左側頬粘膜は表面正常で、触診にて咬筋相当部に可動性で軽度の圧痛を伴う30mm大の骨様硬の病変を触知した。単純CT画像では、左側狡筋は右側と比較し腫大し、内部に長径22mm大、外形不整な高吸収域を認めた。病変内部に長径3〜6mm大の複数の類円形石灰物を認めた。造影CT画像では、高吸収域に不均一な造影効果を認め、造影性の高い領域では血管腔と同程度の高い造影性を示した。腫瘤内石灰化物の多くは内部に核を有し、層板状構造に近い性状であった。MRI所見では、病変内部はT1強調画像では低信号から筋と同程度の不均一な信号強度、T2強調画像では低信号から高信号の不均一な信号強度を呈し、石灰化物に相当する部分はほぼ無信号を呈した。全身麻酔下で口腔内より腫瘤の摘出術を施行した。現在、術後3年経過しているが、再発はなく経過良好である。摘出標本の病理組織学的診断は静脈石を伴った静脈奇形であった。

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J01073&link_issn=&doc_id=20171130350014&doc_link_id=10.5794%2Fjjoms.63.593&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.63.593&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Rapid occurrence of left ventricular thrombus associated with platinum-based chemotherapy plus cetuximab for the treatment of metastatic squamous cell carcinoma of the head and neck: A case report. International journal

Atsushi Ikeda, Eiki Yamachika, Masahide Mizutani, Masakazu Matsubara, Norifumi Moritani, Kazuki Nakatsuji, Seiji Iida

Molecular and clinical oncology 7 ( 5 ) 833 - 836 2017.11

Language：English Publishing type：Research paper (scientific journal)

Platinum-based chemotherapy plus cetuximab represents the first-line treatment for recurrent or metastatic squamous cell carcinoma of the head and neck. The most common adverse events associated with cetuximab are infusion reactions and skin reactions, and a risk of venous thromboembolic events has also recently been reported in association with cetuximab. It is well known that thrombosis is a common complication of malignancy, and represents the second most frequent cause of mortality in cancer patients. The present study reports the case of a 79-year-old man who presented with lung and liver metastases from tongue squamous cell carcinoma, for which platinum-based chemotherapy plus cetuximab was administered. After 1 cycle, the patient showed rapid growth of a left ventricular (LV) thrombus, despite ongoing antiplatelet therapy for an old myocardial infarction. Anticoagulant therapy was administered to treat the LV thrombus, which resolved within 1 week. To the best of our knowledge, this represents the first reported case of rapidly occurring LV thrombus associated with platinum-based chemotherapy plus cetuximab. Platinum-based chemotherapy plus cetuximab may be associated with a higher risk of embolic thrombus.

DOI： 10.3892/mco.2017.1393

A case of non-clostridial gas gangrene caused by antiresorptive agent-related osteonecrosis of the jaw

Masakazu MATSUBARA, Nobuhisa ISHIDA, Atsushi IKEDA, Eiki YAMACHIKA, Sho AKASHI, Seiji IIDA

Japanese Journal of Oral and Maxillofacial Surgery 63 ( 10 ) 506 - 511 2017.10

Maxillary Anterior Segmental Distraction Osteogenesis to Correct Maxillary Deficiencies in a Patient With Cleft Lip and Palate Reviewed

Asuka Kageyama-Iwata, Seiji Haraguchi, Seiji Iida, Tomonao Aikawa, Takashi Yamashiro

CLEFT PALATE-CRANIOFACIAL JOURNAL 54 ( 4 ) 465 - 473 2017.5

Language：English Publishing type：Research paper (scientific journal) Publisher：ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS

This report describes a case of successful orthodontic treatment using maxillary anterior segmental distraction osteogenesis with an internal maxillary distractor and bilateral sagittal split ramus osteotomy in a girl with cleft lip and palate. A 16-year-old girl with unilateral cleft lip and palate exhibited midface retrusion because of growth inhibition of the maxillary complex and mandibular excess. After the presurgical orthodontic treatment, 6.0-mm advancement of the maxillary anterior segment and 4.0-mm set back of the mandible were performed. After a retention period, the patient's midface convexity was greatly improved and the velopharyngeal competence was preserved without relapse.

DOI： 10.1597/14-326

Medication-related osteonecrosis of the jaws caused lethal sepsis in an edentulous patient with multiple systemic factors

Keisuke Yamashiro, Aki Sato, Fumihiko Okazaki, Makoto Nakano, Koichi Sawaki, Yasuhisa Hirata, Eiki Yamachika, Seiji Iida, Shogo Takashiba

Clinical Case Reports 5 ( 2 ) 97 - 103 2017.2

当科におけるインプラント上顎洞内迷入症例の臨床的検討

松村達志, 仲田直樹, 山近英樹, 水川展吉, 池田篤司, 森谷徳文, 飯田征二

岡山歯学会雑誌 35 ( 2 ) 43 - 48 2017.1

Differential Changes in Neuronal Excitability in the Spinal Dorsal Horn After Spinal Nerve Ligation in Rats

Ryuji Terayama, Yuya Yamamoto, Noriko Kishimoto, Mitsuyasu Tabata, Kotaro Maruhama, Seiji Iida, Tomosada Sugimoto

Neurochemical Research 41 ( 11 ) 2880 - 2889 2016.11

A case of a calcifying cystic odontogenic tumor with odontoma in a 5-year-old boy

Norifumi Moritani, Naoki Nakata, Eiki Yamachika, Tatsushi Matsumura, Hitoshi Nagatsuka, Seiji Iida

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 28 ( 5 ) 421 - 425 2016.9

TGF-beta in jaw tumor fluids induces RANKL expression in stromal fibroblasts Reviewed

Chiaki Yamada, Tomonao Aikawa, Emi Okuno, Kazuaki Miyagawa, Katsuhiko Amano, Sosuke Takahata, Masaaki Kimata, Masaya Okura, Seiji Iida, Mikihiko Kogo

INTERNATIONAL JOURNAL OF ONCOLOGY 49 ( 2 ) 499 - 508 2016.8

Language：English Publishing type：Research paper (scientific journal) Publisher：SPANDIDOS PUBL LTD

Odontogenic tumors and cysts, arising in the jawbones, grow by resorption and destruction of the jawbones. However, mechanisms underlying bone resorption by odontogenic tumors/cysts remain unclear. Odontogenic tumors/cysts comprise odontogenic epithelial cells and stromal fibroblasts, which originate from the developing tooth germ. It has been demonstrated that odontogenic epithelial cells of the developing tooth germ induce osteoclastogenesis to prevent the tooth germ from invading the developing bone to maintain its structure in developing bones. Thus, we hypothesized that odontogenic epithelial cells of odontogenic tumors/cysts induce osteoclast formation, which plays potential roles in tumor/cyst outgrowth into the jawbone. The purpose of this study was to examine osteoclastogenesis by cytokines, focusing on transforming growth factor-beta (TGF-beta), produced by odontogenic epithelial cells. We observed two pathways for receptor activator of NF-kappa B ligand (RANKL) induction by keratocystic odontogenic tumor fluid: the cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway through interleukin-1 alpha (IL-1 alpha) signaling and non-COX-2/PGE2 pathway through TGF-beta receptor signaling. TGF-beta 1 and IL-1 alpha produced by odontogenic tumors/cysts induced osteoclastogenesis directly in the osteoclast precursor cells and indirectly via increased RANKL induction in the stroma.

DOI： 10.3892/ijo.2016.3548

Asymmetric Anterior Distraction for Transversely Distorted Maxilla and Midfacial Anteroposterior Deficiency in a Patient With Cleft Lip/Palate: Two-Stage Surgical Approach Reviewed

Kae Hirata, Chihiro Tanikawa, Tomonao Aikawa, Kohji Ishihama, Mikihiko Kogo, Seiji Iida, Takashi Yamashiro

CLEFT PALATE-CRANIOFACIAL JOURNAL 53 ( 4 ) 491 - 498 2016.7

Language：English Publishing type：Research paper (scientific journal) Publisher：ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS

The present report describes a male patient with a unilateral cleft lip and palate who presented with midfacial anteroposterior and transverse deficiency. Correction involved a two-stage surgical-orthodontic approach: asymmetric anterior distraction of the segmented maxilla followed by two-jaw surgery (LeFort I and bilateral sagittal splitting ramus osteotomies). The present case demonstrates that the asymmetric elongation of the maxilla with anterior distraction is an effective way to correct a transversely distorted alveolar form and midfacial anteroposterior deficiency. Furthermore, successful tooth movement was demonstrated in the new bone created by distraction.

DOI： 10.1597/14-322

Functional peptide KP24 enhances submandibular gland tissue growth in vitro

Atsushi Ikeda, Hiroaki Taketa, Gulsan Ara Sathi, Yoshiaki Hirano, Seiji Iida, Takuya Matsumoto

Regenerative Therapy 3 108 - 113 2016.3

Stage IV sporadic Burkitt's leukaemia with osteolysis in the maxillary sinuses

Yohsuke Yoshioka, Eiki Yamachika, Masakazu Matsubara, Seiji Iida

Journal of Surgical Case Reports 2016 ( 2 ) rjw011 - rjw011 2016.2

Anti-osteoporosis effects of 1,4-dihydroxy-2-naphthoic acid in ovariectomized mice with increasing of bone density Reviewed

Kita Kenichiro, Yamachika Eiki, Matsubara Masakazu, Tsujigiwa Hidetsugu, Ishida Nobuhisa, Moritani Norifumi, Matsumura Tatsushi, Mizutani Masahide, Fujita Yuki, Takabatake Kiyofumi, Ejima Kenichiro, Nagatsuka Hitoshi, Yamaguchi Yoshinori, Iida Seiji

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY 28 ( 1 ) 66 - 72 2016.1

Publishing type：Research paper (scientific journal)

Objective: 1,4-Dihydroxy-2-naphthoic acid (DHNA) is the main component of the metabolic products after fermentation by Propionibacterium freudenreichii ET-3. In this study, DHNA, vitamin K2 (VK2), and risedronate (Ris) were administered to ovariectomized (OVX) mice to ascertain their suppressive effects on bone mass reduction. Methods: Fifty mice were divided into five groups: Sham, OVX, DHNA, VK2, and Ris groups. The drugs were administered daily for 8 weeks. Subsequently, blood was collected from the orbital venous plexus. The bilateral femurs and L5 lumbar vertebra were excised. To determine the effects of the drugs, we performed histomorphometric analyses of the left femur and L5 by micro-CT, biochemical analyses of serum samples, and histological analyses of the right femur. Results: The results for the total bone mineral density, bone volume density, trabecular thickness, trabecular number, trabecular separation, and histological analyses showed that bone resorption was improved in the DHNA and Ris groups compared with the OVX group. Furthermore, the biochemical analyses revealed that the production of inflammatory cytokines was suppressed in the DHNA and Ris groups. Conclusions: The present findings show that DHNA suppresses the bone mass reduction in OVX mice, suggesting that it could be an alternative treatment for postmenopausal osteoporosis.

DOI： 10.1016/j.ajoms.2015.07.001

A case of diffuse sclerotic osteomyelitis of the mandible associated with SAPHO syndrome successfully treated with an oral bisphosphonate

Atsushi Ikeda, Eiki Yamachika, Tatsushi Matsumura, Masahide Mizutani, Yuichi Matsui, Seiji Iida

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 27 ( 6 ) 858 - 861 2015.11

Treatment of Osteonecrosis of the Jaw

Eiki Yamachika, Masakazu Matsubara, Atsushi Ikeda, Tatsushi Matsumura, Norifumi Moritani, Seiji Iida

Journal of Craniofacial Surgery 26 ( 7 ) e575 - e577 2015.10

Anatomical relationship between the mandibular foramen and the lateral surface shape of the mandibular ramus using CT

Yu Goda, Tatsushi Matsumura, Yoshinobu Yanagi, Norifumi Moritani, Seiji Iida

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY 27 ( 5 ) 614 - 623 2015.9

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

Objective: The antilingular prominence (AP) is a well-known landmark used during planning of intraoral vertical ramus osteotomy (IVRO) in order to prevent inferior alveolar nerve (IAN) injury, but the location of this landmark is not always clear. In this study, we analyzed the anatomical relationship between the mandibular foramen (MF) and the lateral surface shape of the mandibular ramus for use during IVRO.Patients and methods: We retrospectively analyzed 276 mandibular halves in 67 patients with mandibular deformity and 71 patients without deformity imaged at our department from April 2003 to March 2014. We defined 17 points on the mandibular ramus, and examined the anatomical relationships using multiplanar reconstruction (MPR) images and three-dimensional computed tomography (3DCT) created from preoperative CT data.Results: The prevalence of the AP was 57.6% (159/276) of all cases. The MF was located inferior to the AP in all cases; it was posterior to the AP in 50.3% (80/159) of cases and the sigmoid notch (SN) in 24.6% (68/276) of cases. The minimum horizontal distance between the mandibular posterior ramus border and the MF was 9.28 mm in all cases.Conclusion: The AP cannot always serve as a reference point to prevent IAN damage during IVRO. The osteotomy incision should be placed within 9 mm of the posterior mandibular ramus border in order to prevent intraoperative IAN damage. However, preoperative review of planned osteotomy incisions is necessary in every case. (c) 2014 Asian AOMS, ASOMP, JSOP, JSOMS, JSOM, and JAMI. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.ajoms.2014.11.007

Maxillary Expansion and Midline Correction by Asymmetric Transverse Distraction Osteogenesis in a Patient With Unilateral Cleft Lip/Palate: A Case Report Reviewed

Yuko Shintaku, Chihiro Tanikawa, Seiji Iida, Tomonao Aikawa, Mikihiko Kogo, Takashi Yamashiro

CLEFT PALATE-CRANIOFACIAL JOURNAL 52 ( 5 ) 618 - 624 2015.9

Language：English Publishing type：Research paper (scientific journal) Publisher：ALLIANCE COMMUNICATIONS GROUP DIVISION ALLEN PRESS

This case report presents the management of a female patient with unilateral cleft lip and palate presenting with skeletal Class III malocclusion and a narrow upper dental arch with a midline deviation. The treatment plan involved asymmetric transverse distraction osteogenesis of the maxilla to make the upper dental midline coincident with the facial midline. After the treatment, a good facial profile and a close intercuspation of teeth were achieved. Occlusion remained stable with normal overjet and overbite after 2-year retention.

DOI： 10.1597/13-278

Maxillary Advancement for Unilateral Crossbite in a Patient with Sleep Apnea Syndrome Reviewed

Mitsuhiro Hoshijima, Tadashi Honjo, Norifumi Moritani, Seiji Iida, Takashi Yamashiro, Hiroshi Kamioka

ACTA MEDICA OKAYAMA 69 ( 3 ) 177 - 182 2015.6

Language：English Publishing type：Research paper (scientific journal) Publisher：OKAYAMA UNIV MED SCHOOL

This article reports the case of a 44-year-old male with skeletal Class III, Angle Class III malocclusion and unilateral crossbite with concerns about obstructive sleep apnea syndrome (OSAS), esthetics and functional problems. To correct the skeletal deformities, the maxilla was anteriorly repositioned by employing LeFort I osteotomy following pre-surgical orthodontic treatment, because a mandibular setback might induce disordered breathing and cause OSAS. After active treatment for 13 months, satisfactory occlusion was achieved and an acceptable facial and oral profile was obtained. In addition, the apnea hypopnea index (AHI) decreased from 18.8 preoperatively to 10.6 postoperatively. Furthermore, after a follow-up period of 7 months, the AHI again significantly decreased from 10.6 to 6.2. In conclusion, surgical advancement of the maxilla using LeFort I osteotomy has proven to be useful in patients with this kind of skeletal malocclusion, while preventing a worsening of the OSAS.

DOI： 10.18926/AMO/53525

Other Link： http://orcid.org/0000-0002-4419-9643

Activated Microglia Contribute to Convergent Nociceptive Inputs to Spinal Dorsal Horn Neurons and the Development of Neuropathic Pain

Yuya Yamamoto, Ryuji Terayama, Noriko Kishimoto, Kotaro Maruhama, Masahide Mizutani, Seiji Iida, Tomosada Sugimoto

Neurochemical Research 40 ( 5 ) 1000 - 1012 2015.5

Possible Involvement of Convergent Nociceptive Input to Medullary Dorsal Horn Neurons in Intraoral Hyperalgesia Following Peripheral Nerve Injury

Ryuji Terayama, Hiroki Tsuchiya, Shinji Omura, Kotaro Maruhama, Masahide Mizutani, Seiji Iida, Tomosada Sugimoto

Cellular and Molecular Neurobiology 35 ( 3 ) 417 - 423 2015.4

Peripheral nerve injury activates convergent nociceptive input to dorsal horn neurons from neighboring intact nerve

Ryuji Terayama, Yuya Yamamoto, Noriko Kishimoto, Kotaro Maruhama, Masahide Mizutani, Seiji Iida, Tomosada Sugimoto

Experimental Brain Research 233 ( 4 ) 1201 - 1212 2015.4

Convergent Nociceptive Input to Spinal Dorsal Horn Neurons After Peripheral Nerve Injury

Ryuji Terayama, Noriko Kishimoto, Yuya Yamamoto, Kotaro Maruhama, Hiroki Tsuchiya, Masahide Mizutani, Seiji Iida, Tomosada Sugimoto

Neurochemical Research 40 ( 3 ) 438 - 445 2015.3

A case of malignant pleural mesothelioma with metastasis to the upper jaw

SAWAKI Koichi, OKAZAKI Fumihiko, SATO Aki, NAKANO Makoto, TAKAGI Shin, IIDA Seiji

Journal of Oral Surgery Society of Japan 61 ( 3 ) 168 - 172 2015

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

Mesothelioma is a rare neoplasm that arises from the pleura or peritoneum. Although malignant mesothelioma is known to spread hematogenously, causing metastasis to various organs, there have been few reports on oral metastasis. The patient was a 75-year-old man who had an elastic soft mass, measuring 38 × 20 mm, in the right upper jaw gingiva. On biopsy the lesion was histopathologically diagnosed as a malignant pleural mesothelioma with metastasis to the upper jaw. The lesion shrank in response to radiotherapy. We have described a case of malignant pleural mesothelioma arising in the upper jaw gingiva. We discuss the related literature and summarize our findings.

DOI： 10.5794/jjoms.61.168

Other Link： https://jlc.jst.go.jp/DN/JLC/20009068467?from=CiNii

A case of bilateral chylothorax occurring after radical neck dissection

IKEDA Atsushi, MIZUTANI Masahide, YAMAMOTO Yuya, ARIMURA Yuki, UEMURA Ayumi, IIDA Seiji

Journal of Oral Surgery Society of Japan 61 ( 5 ) 288 - 292 2015

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

Bilateral chylothorax is a rare complication after radical neck dissection. We report a case of bilateral chylothorax that developed after left radical neck dissection. A 40-year-old man was given a diagnosis of secondary left cervical lymph-node metastasis from left-sided tongue cancer (T1N0M0), and supraomohyoid neck dissection was performed. Since multiple lymph-node metastases had been found, modified radical neck dissection was performed. We ligated the thoracic duct because it ruptured intraoperatively. On the first postoperative day, a chyle leak was diagnosed, and the thoracic duct was ligated again. The chyle leak resolved, but on the fourth postoperative day, the patient complained of dyspnea and chest discomfort. Computed tomographic scans and chest X-ray films showed bilateral pleural effusions. Diagnostic thoracentesis was performed. Milky fluid was aspirated, and chylothorax was diagnosed. We used a conservative management approach, which involved total parenteral nutrition with total enteric rest. Repeated chest X-ray films showed no evidence of pleural effusion, and the patient was started to receive a low-fat diet on the 11th postoperative day. The patient had recovered completely.

DOI： 10.5794/jjoms.61.288

Other Link： https://jlc.jst.go.jp/DN/JLC/20011890438?from=CiNii

岡山大学病院口腔がん専門外来と岡山市歯科医師会の連携による口腔がん検診研修会の概要とアンケート結果について

岸本晃治, 岡崎景, 西山明慶, 居樹秀明, 松村達志, 伊原木聰一郎, 銅前昇平, 吉岡徳枝, 栗尾奈愛, 矢尾真弓, 小畑協一, 尾野裕子, 志茂剛, 壺内智郎, 飯田征二, 佐々木朗

岡山歯学会雑誌 33 ( 2 ) 23 - 28 2014.12

Language：Japanese Publisher：岡山歯学会

口腔癌検診研修会基礎コースを修了した歯科医師を対象に、研修会終了後にアンケート調査を行った。2013年に行われた3回の研修会の研修者の合計は46人(3人が2回研修)であった。臨床経験年数は10〜42年(平均23.6年、中央値25年)に比較的長い研修者が多かった。口腔癌症例経験ありは70%に認められ、経験症例数は1〜3例が多かった。口腔癌症例経験者の中で癌の疑いがあると診断して専門機関に紹介した症例が93%と大部分を占めた。しかし、その中で早期癌を診断できた症例は45%に過ぎず、初診時に進行していた症例も46例に認められた。また、紹介が少し遅くなった症例が9%認められたが患者が専門機関をなかなか受診してくれなかった例も1例あった。癌の部位は舌が最も多く41%認められ、下顎歯肉32%、口底13%と続いた。研修会の時間・レベルは概ね適切で、講義・実習・テキストもためになり、今後の臨床に役立つとの回答が得られた。再研修の必要性は91%と多かったが、アドバンスコースの希望者は69%に留まり、ベーシックコースの希望者も22%認められた。また、再研修までの期間は1年の35%を前後にばらつきが認められた。研修者はより実践的に役立つ研修内容を希望していた。

Assessment of intraoral mucosal pain induced by the application of capsaicin

Ryuji Terayama, Kotaro Maruhama, Hiroki Tsuchiya, Masahide Mizutani, Seiji Iida, Tomosada Sugimoto

Archives of Oral Biology 59 ( 12 ) 1334 - 1341 2014.12

Surrounding cells affect the gene expression pattern of human beta-defensins in squamous cell carcinoma in vitro

Anticancer Res 34 ( 11 ) 6443 - 6449 2014.11

Effect of geometry and microstructure of honeycomb TCP scaffolds on bone regeneration Reviewed

Kiyofumi Takabatake, Eiki Yamachika, Hidetsugu Tsujigiwa, Yasushi Takeda, Mariko Kimura, Shin Takagi, Hitoshi Nagatsuka, Seiji Iida

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 102 ( 9 ) 2952 - 2960 2014.9

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY-BLACKWELL

In recent years, artificial biological materials have been commonly used for the treatment of bone tissue defects caused by trauma, tumors, or surgical stress. Although tricalcium phosphate (TCP) is a promising absorbent bone tissue reconstruction biomaterial, it has been reported that its biocompatibility and osteoconductivity depend on its preparation method and sintering temperature. In addition, although it is thought that the microenvironment produced by the extracellular matrix plays an important role in cell growth and differentiation, there have been few studies on how the geometric structure of artificial biological materials affects cells. In the present study, a new honeycomb TCP scaffold containing through-holes with diameters of 300 mm has been developed. The influence of the sintering temperature on the crystal structure and material properties of the honeycomb TCP scaffold was investigated using scanning electron microscopy and X-ray diffraction. Its biocompatibility and osteoconductivity were also evaluated by implantation into experimental animals. It was found that a beta-TCP scaffold sintered at 1200 degrees C exhibited high biocompatibility and osteoconductivity, and when it was loaded with BMP-2, it exhibited both osteoconductivity and osteoinductivity, promoting rapid bone formation in both ectopic and orthotopic areas. It is thus a highly promising bone reconstruction material that is expected to find clinical applications. (C) 2013 Wiley Periodicals, Inc.

DOI： 10.1002/jbm.a.34966

CCN2 as a Novel Molecule Supporting Energy Metabolism of Chondrocytes

Aya Maeda-Uematsu, Satoshi Kubota, Harumi Kawaki, Kazumi Kawata, Yoshiaki Miyake, Takako Hattori, Takashi Nishida, Norifumi Moritani, Karen M. Lyons, Seiji Iida, Masaharu Takigawa

Journal of Cellular Biochemistry 115 ( 5 ) 854 - 865 2014.5

Hemoglobin Receptor Protein from Porphyromonas gingivalis Induces Interleukin-8 Production in Human Gingival Epithelial Cells through Stimulation of the Mitogen-Activated Protein Kinase and NF-κB Signal Transduction Pathways

Yuki Fujita, Masaaki Nakayama, Mariko Naito, Eiki Yamachika, Tetsuyoshi Inoue, Koji Nakayama, Seiji Iida, Naoya Ohara

Infection and Immunity 82 ( 1 ) 202 - 211 2014.1

Publishing type：Research paper (scientific journal) Publisher：American Society for Microbiology

ABSTRACT

Periodontitis is an inflammatory disease of polymicrobial origin affecting the tissues supporting the tooth. The oral anaerobic bacterium Porphyromonas gingivalis , which is implicated as an important pathogen for chronic periodontitis, triggers a series of host inflammatory responses that promote the destruction of periodontal tissues. Among the virulence factors of P. gingivalis , hemoglobin receptor protein (HbR) is a major protein found in culture supernatants. In this study, we investigated the roles of HbR in the production of inflammatory mediators. We found that HbR induced interleukin-8 (IL-8) production in the human gingival epithelial cell line Ca9-22. p38 mitogen-activated protein kinase (MAPK) and extracellular signal-related kinase 1/2 (Erk1/2) were activated in HbR-stimulated Ca9-22 cells. Inhibitors of p38 MAPK (SB203580) and Erk1/2 (PD98059) blocked HbR-induced IL-8 production. Additionally, HbR stimulated the translocation of NF-κB-p65 to the nucleus, consistent with enhancement of IL-8 expression by activation of the NF-κB pathway. In addition, small interfering RNA (siRNA) targeting activating transcription factor 2 (ATF-2) or cyclic AMP-response element-binding protein (CREB) inhibited HbR-induced IL-8 production. Moreover, pretreatment with SB203580 and PD98059 reduced HbR-induced phosphorylation of CREB and ATF-2, respectively. Combined pretreatment with an inhibitor of NF-κB (BAY11-7082) and SB203580 was more efficient in inhibiting the ability of HbR to induce IL-8 production than pretreatment with either BAY11-7082 or SB203580 alone. Thus, in Ca9-22 cells, the direct activation of p38 MAPK and Erk1/2 by HbR caused the activation of the transcription factors ATF-2, CREB, and NF-κB, thus resulting in the induction of IL-8 production.

DOI： 10.1128/iai.01140-12

Voice characteristics before versus after mandibular setback surgery in patients with mandibular prognathism using nonlinear dynamics and conventional acoustic analyses Reviewed

Katsuaki Mishima, Norifumi Moritani, Hiroyuki Nakano, Asuka Matsushita, Seiji Iida, Yoshiya Ueyama

JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY 41 ( 8 ) 706 - 709 2013.12

Language：English Publishing type：Research paper (scientific journal) Publisher：CHURCHILL LIVINGSTONE

Objectives: The purpose of this study was to explore the voice characteristics of patients with mandibular prognathism, and to investigate the effects of mandibular setback surgery on these characteristics using nonlinear dynamics and conventional acoustic analyses.
Materials and methods: Sixteen patients (8 males and 8 females) who had skeletal 3, class III malocclusion without cleft palate, and who underwent a bilateral sagittal split ramus osteotomy (BSSRO), were enrolled. As controls, 50 healthy adults (25 males and 25 females) were enrolled. The mean first LEs (mLE1) computed for each one-second interval, and the fundamental frequency (F0) and frequencies of the first and second formant (F1, F2) were calculated for each Japanese vowel.
Results and conclusions: The mLE1s for /u/ in males, and /o/ in females and the F2s for /i/ and /u/ in males, changed significantly after BSSRO. Class III voice characteristics were observed in the mLE1s for /i/ in both males and females, in the F0 for /a/, /i/, /u/ and /o/ in females, and in the F1 and F2 for /a/ in males, and the F1 for /u/ and the F2 for /i/ in females. Most of these characteristics were preserved after BSSRO. (C) 2013 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.jcms.2012.01.021

軟骨細胞の代謝の基本を支えるCCN2の重要性(Essential role of CCN2 that supports the basal energy metabolism in chondrocytes)

前田彩, 久保田聡, 三宅由晃, 河田かずみ, 服部高子, 西田崇, 森谷徳文, 川木晴美, カレン・ライアン, 飯田征二, 滝川正春

日本生化学会大会プログラム・講演要旨集 86回 2T06a - 15 2013.9

CCNファミリー研究のメルティングポット CCN2は軟骨細胞のエネルギー代謝に重要である

前田彩, 久保田聡, 川木晴美, 河田かずみ, 三宅由晃, 服部高子, 西田崇, 森谷徳文, 飯田征二, 滝川正春

Journal of Oral Biosciences Supplement 2013 95 - 95 2013.9

The Role of Bone Marrow-Derived Cells During the Bone Healing Process in the GFP Mouse Bone Marrow Transplantation Model Reviewed International journal

Hidetsugu Tsujigiwa, Yasuhisa Hirata, Naoki Katase, Rosario Rive, ra Buery, Ryo Tamamura, Satoshi Ito, Shin Takagi, Seiji Iida, Hitoshi Nagatsuka

Calcified Tissue International 92 ( 3 ) 296 - 306 2013.3

Language：English Publishing type：Research paper (scientific journal)

Bone healing is a complex and multistep process in which the origin of the cells participating in bone repair is still unknown. The involvement of bone marrow-derived cells in tissue repair has been the subject of recent studies. In the present study, bone marrow-derived cells in bone healing were traced using the GFP bone marrow transplantation model. Bone marrow cells from C57BL/6-Tg (CAG-EGFP) were transplanted into C57BL/6 J wild mice. After transplantation, bone injury was created using a 1.0-mm drill. Bone healing was histologically assessed at 3, 7, 14, and 28 postoperative days. Immunohistochemistry for GFP; double-fluorescent immunohistochemistry for GFP-F4/80, GFP-CD34, and GFP-osteocalcin; and double-staining for GFP and tartrate-resistant acid phosphatase were performed. Bone marrow transplantation successfully replaced the hematopoietic cells into GFP-positive donor cells. Immunohistochemical analyses revealed that osteoblasts or osteocytes in the repair stage were GFP-negative, whereas osteoclasts in the repair and remodeling stages and hematopoietic cells were GFP-positive. The results indicated that bone marrow-derived cells might not differentiate into osteoblasts. The role of bone marrow-derived cells might be limited to adjustment of the microenvironment by differentiating into inflammatory cells, osteoclasts, or endothelial cells in immature blood vessels.

DOI： 10.1007/s00223-012-9685-3

Unilateral delayed eruption of a mandibular permanent canine and the maxillary first and second molars, and agenesis of the maxillary third molar Reviewed

Jae Hyun Park, Kiyoshi Tai, Seiji Iida

AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS 143 ( 1 ) 134 - 139 2013.1

Language：English Publishing type：Research paper (scientific journal) Publisher：MOSBY-ELSEVIER

Delayed tooth eruption can affect the accuracy of orthodontic diagnosis and treatment planning and could delay overall treatment. A girl, aged 7 years 4 months, who had unilateral delayed eruption of several teeth was successfully treated. The evaluation of delayed tooth eruption should be considered by the orthodontist because the role of these teeth can affect the overall treatment of malocclusion. In patients with delayed tooth eruption, careful and accurate diagnosis and treatment planning will allow the orthodontist to start treatment at the proper stage and might reduce the overall orthodontic treatment time. (Am J Orthod Dentofacial Orthop 2013;143:134-9)

DOI： 10.1016/j.ajodo.2011.11.024

Toluene Exposure Leads to a Change in Expression Patterns of β Defensins in the Mouse Tracheal Epithelium

Takeda Seiko, Yamaai Tomoichiro, Kaneda Yoshihiro, Mizukawa Nobuyoshi, Iida Seiji, Fujimaki Hidekazu

J Toxicol Pathol 26 ( 1 ) 35 - 40 2013

Language：English Publisher：JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY

Defensins are generally implicated in the quick resistance of epithelial surfaces to microbials; however, recent reports have indicated that defensins also have unknown purposes in relation to noninfectious diseases. In this study, the localization patterns of anti-microbial peptides, β defensins (BDs), in the tracheal epithelium of male C3H mice under exposure to toluene were analyzed by immunohistochemistry. Mice were exposed one to ten times to toluene for 30 min by nose-only inhalation. Expression of BDs was revealed by immunohistochemistry in serial sections of trachea after the final exposure. Expression of BD-1 was usually observed at almost the same levels in all exposure groups, and expression of BD-2 was observed in the control group; however, the signals for BD-2 decreased gradually with frequency of exposure. In the group exposed ten times, expression of BD-2 decreased to far lower than that of the control group. No expression of BD-3 was detected in any groups. Interestingly, expression of BD-4 increased to the maximum in the group exposed four times and decreased to a level lower than that of the control in the group exposed ten times. The results of the present study indicated that toluene gas might change the expression pattern of BDs in the tracheal epithelial cells. The oscillation of expression of BD-4 was quite characteristic and might contribute to morphological damage in on the epithelial cells.

DOI： 10.1293/tox.26.35

Other Link： https://jlc.jst.go.jp/DN/JALC/10017550764?from=CiNii

Maxillary Anterior Segmental Distraction Osteogenesis (MASDO) for Cleft Patients

KOGO Mikihiko, AIKAWA Tomonao, HARADA Takeshi, ISHIHAMA Kohji, HIGUCHI Masataka, USHIMURA Ayako, OKURA Masaya, IIDA Seiji

Bulletin Of Japanese Society for Jaw Deformities 22 S7 - S14 2012.12

bFGFによるマウス骨由来間葉系幹細胞の増殖

高畠清文, 山近英樹, 喜多憲一郎, 金田祥弘, 妹尾昌紀, 片岡陽平, 飯田征二

日本再生歯科医学会誌 10 ( 1 ) 52 - 52 2012.12

軟骨細胞の代謝システムにおけるCCN2の役割

前田彩, 久保田聡, 三宅由晃, 河田かずみ, 服部高子, 西田崇, 森谷徳文, 川木晴美, Lyons Karen M., 飯田征二, 滝川正春

岡山歯学会雑誌 31 ( 2 ) 93 - 94 2012.12

Solid-type primary intraosseous squamous cell carcinoma of the mandible: A case report with histopathological and imaging features Reviewed

Hidenobu Matsuzaki, Naoki Katase, Tatsushi Matsumura, Marina Hara, Yoshinobu Yanagi, Hitoshi Nagatsuka, Seiji Iida, Jun-Ichi Asaumi

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 114 ( 5 ) e71 - e77 2012.11

Language：English Publishing type：Research paper (scientific journal)

Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant odontogenic tumor arising from odontogenic epithelial remnants within the jawbones. PIOSCC is histopathologically divided into 3 types: solid-type carcinoma, carcinoma derived from a keratocystic odontogenic tumor, and carcinoma derived from an odontogenic cyst. In this article, we report a case of solid-type PIOSCC involving reactive bone formation in the mandible in a 60-year-old female patient together with its histopathological and imaging findings. © 2012 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.oooo.2012.05.019

CCN2/CTGF欠損が軟骨細胞のエネルギー代謝に及ぼす影響

前田彩, 久保田聡, 服部高子, 西田崇, 飯田征二, 滝川正春

Journal of Oral Biosciences Supplement 2012 96 - 96 2012.9

The morphological features and developmental changes of the philtral dimple: a guide to surgical intervention in cases of cleft lip. Reviewed

Kishi N, Tanaka S, Iida S, Kogo M

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 40 ( 3 ) 215 - 222 2012.4

Language：English Publishing type：Research paper (scientific journal) Publisher：CHURCHILL LIVINGSTONE

Objective: This study was undertaken to analyse in detail the morphological features of the philtral dimple and the developmental changes of philtral morphology, including a comparison with patients with a cleft lip.Patients and participants: Fifty-five normal Japanese adults, seventy-five children and fifteen patients with complete unilateral cleft lip were referred for analysis.Design: 3D facial data were acquired with a non-contacting laser scanner. We calculated the desired linear and angular components, defining the features of the philtrum with analysing software.Results: The philtral dimple was morphologically expressed by the two different deepest points in the horizontal and sagittal sectional view, respectively. These decreased with age and did not show any correlation. In contrast, philtral measurements on the X-Y coordinates increased during the course of development. Most of the linear and angular variables in the patients with the cleft lip had exhibited greater values than the normal subjects, reflecting the deformed philtral morphology.Conclusions: To obtain an optimally natural philtral construction accompanied by a symmetrical lip in cleft surgery, it is critical to take into consideration both the geometric features of the philtral depth and age-appropriate morphological features of the philtrum as objective criteria. (C) 2011 European Association for Cranio-Maxillo-Facial Surgery.

DOI： 10.1016/j.jcms.2011.04.019

Basic fibroblast growth factor supports expansion of mouse compact bone-derived mesenchymal stem cells (MSCs) and regeneration of bone from MSC in vivo Reviewed

Yamachika Eiki, Tsujigiwa Hidetsugu, Matsubara Masakazu, Hirata Yasuhisa, Kita Kenichiro, Takabatake Kiyofumi, Mizukawa Nobuyoshi, Kaneda Yoshihiro, Nagatsuka Hitoshi, Iida Seiji

JOURNAL OF MOLECULAR HISTOLOGY 43 ( 2 ) 223 - 233 2012.4

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER

Some progress has been made in development of methods to regenerate bone from cultured cells, however no method is put to practical use. Here, we developed methods to isolate, purify, and expand mesenchymal stem cells (MSCs) from mouse compact bone that may be used to regenerate bone in vivo. These cells were maintained in long-term culture and were capable of differentiating along multiple lineages, including chondrocyte, osteocyte, and adipocyte trajectories. We used standard cell isolation and culture methods to establish cell cultures from mouse compact bone and bone marrow. Cultures were grown in four distinct media to determine the optimal composition of culture medium for bone-derived MSCs. Putative MSCs were subjected to flow cytometry, alkaline phosphatase assays, immunohistochemical staining, and several differentiation assays to assess cell identity, protein expression, and developmental potential. Finally, we used an in vivo bone formation assay to determine whether putative MSCs were capable of regenerating bone. We found that compact bone of mice was a better source of MCSs than the bone marrow, that growth in plastic flasks served to purify MSCs from hematopoietic cells, and that MSCs grown in basic fibroblast growth factor (bFGF)-conditioned medium were, based on multiple criteria, superior to those grown in leukemia inhibitory factor-conditioned medium. Moreover, we found that the MSCs isolated from compact bone and grown in bFGF-conditioned medium were capable of supporting bone formation in vivo. The methods and results described here have implications for understanding MSC biology and for clinical purpose.

DOI： 10.1007/s10735-011-9385-8

Correlation between direct anthropometry and Di3D camera system Reviewed

Jae Hyun Park, Anita Angela Sharma, Kiyoshi Tai, Seiji Iida, Yoshinobu Yanagi, Jun-ichi Asaumi, Je-Won Shin

Journal of Hard Tissue Biology 21 ( 1 ) 87 - 92 2012

Language：English Publishing type：Research paper (scientific journal)

The purpose of this study was to determine the accuracy of a new high resolution digital camerabased three-dimensional system called Di3D by comparing with traditional direct anthropometry using digital calipers. The study sample consisted of 20 young adults, 10 male and 10 female. Facial soft tissue landmarks were identified and five linear distances were measured between the landmarks for each subject using the two methods
Di3D camera system and a digital caliper. No statistically significant differences (P &gt
0.05) were found for all five facial soft tissue distances measured by the Di3D camera system and the digital caliper. The magnitude of differences was very small (mean = 0.73 mm). Good congruence was observed between the means derived from the Di3D system and the digital caliper. The overall mean differences of the five measurements with these two methods were small enough to be clinically insignificant. The results show that both methods are concordant and one method can replace the other in clinical use. © 2012 The Hard Tissue Biology Network Association Printed in Japan, All rights reserved.

DOI： 10.2485/jhtb.21.87

Bone quality and quantity of the anterior maxillary trabecular bone in dental implants sites. Reviewed

Mari Wakimoto, Tatsushi Matsumura, Takaaki Ueno, Nobuyoshi Mizukawa, Seiji Iida

Clin. Oral Impl. Res. 23 1314 - 1319 2012

Nonlinear Dynamic Analysis of Vowels in Cleft Palate Children with or without Hypernasality

Katsuaki Mishima, Hiroyuki Nakano, Tatsushi Matsumura, Norifumi Moritani, Seiji Iida, Yoshiya Ueyama

International Journal of Otolaryngology 2012 1 - 4 2012

Publishing type：Research paper (scientific journal) Publisher：Hindawi Limited

<italic>Objectives</italic>. To clarify the difference between Lyapunov exponents (LEs) for cleft palate (CP) patients with hypernasality versus without hypernasality and to investigate the relationship between their LEs and nasalance scores (NSs).<italic>Material and Methods</italic>. Six CP patients with severe hypernasality (mean age 9.2 years) and six CP patients without hypernasality (mean age 8.0 years) were enrolled. Five Japanese vowels were recorded at 44.1 KHz, and the NSs were measured simultaneously. The mean first LE (mLE₁) from all one-second intervals was computed.<italic>Results</italic>. The mLE₁for /o/ in patients with hypernasality was significantly higher than that in patients without hypernasality. The correlation coefficients between the mLE₁and NS for all vowels were not statistically different.<italic>Conclusion</italic>. The voice signal of /o/ for the patients with hypernasality was more instable than in those without hypernasality. The chaotic phenomenon was independent of nasal resonance in CP voice.

DOI： 10.1155/2012/739523

Other Link： http://downloads.hindawi.com/journals/ijoto/2012/739523.xml

Way to increase mechanical strength during distraction osteogenesis of the mandibular symphysis: technical note Reviewed

Tomonao Aikawa, Kaoru Ohnishi, Hidetake Ohnishi, Seiji Iida

BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY 49 ( 8 ) 670 - 671 2011.12

Novel effects of CCN3 that may direct the differentiation of chondrocytes Reviewed

Danilo Janune, Satoshi Kubota, Takashi Nishida, Harumi Kawaki, Bernard Perbal, Seiji Iida, Masaharu Takigawa

FEBS LETTERS 585 ( 19 ) 3033 - 3040 2011.10

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE BV

Identification and characterization of local molecules directing the differentiation of chondrocytes to either transient or permanent cartilage are major issues in cartilage biology. Here, we found CCN family protein 3 (CCN3) was abundantly produced in rat developing epiphyseal cartilage. Evaluations in vitro showed that CCN3 repressed epiphyseal chondrocyte proliferation, while promoting matrix production in multiple assays performed. Furthermore, CCN3 enhanced the articular chondrocytic phenotype; whereas it repressed the one representing endochondral ossification. Additionally, the phenotype of growth plate chondrocytes and chondrogenic progenitors also appeared to be affected by CCN3 in a similar manner. These findings suggest a significant role of CCN3 in inducing chondrocytes to articular ones during joint formation. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

DOI： 10.1016/j.febslet.2011.08.024

Comprehensive Evaluation of Three-Dimensional Philtral Morphology Reviewed

Naoko Kishi, Susumu Tanaka, Seiji Iida, Mikihiko Kogo

JOURNAL OF CRANIOFACIAL SURGERY 22 ( 5 ) 1606 - 1611 2011.9

Language：English Publishing type：Research paper (scientific journal) Publisher：LIPPINCOTT WILLIAMS & WILKINS

This study was designed to evaluate detailed philtral morphology involving sex and racial differences and to clarify the objective parameters related to subjective judgments regarding the clarity of the philtrum. Fifty-five Japanese and 20 Mexican normal subjects aged 24 to 40 years were recruited, and three-dimensional facial data were acquired using a noncontacting optical surface scanner. The visual classification of the philtral column morphology in Japanese adults using facial photographs revealed that the predominant philtral column shape was different by sex. The three-dimensional anthropometric data showed significant sex differences, which were reflected in the more pronounced visual impression of the philtrum in men. A comparative study between Japanese and Mexican women also revealed certain racial differences. Furthermore, both the philtral depth and central angle of Cupid's bow were extracted as explanatory variables related to the subjective judgments for the clarity of the philtrum. These results suggest that the comprehensive evaluation of philtral morphologic features by three-dimensional analysis is a useful means of identifying the ideal parameters in philtral construction in cleft surgery.

DOI： 10.1097/SCS.0b013e31822e5ebf

CTを用いた前歯部インプラント埋入部位の評価

松村達志, 脇本真理, 太田晃子, 森谷徳文, 池田篤司, 前田彩, 高畠清文, 喜田沙音里, 山近英樹, 水川展吉, 植野高章, 飯田征二

日本口腔外科学会雑誌 57 ( Suppl. ) 286 - 286 2011.9

CCN3-mediated promotion of sulfated proteoglycan synthesis in rat chondrocytes from developing joint heads Reviewed

Danilo Janune, Satoshi Kubota, Noureddine Lazar, Bernard Perbal, Seiji Iida, Masaharu Takigawa

Journal of Cell Communication and Signaling 5 ( 3 ) 167 - 171 2011.8

Language：English Publishing type：Research paper (scientific journal)

Chondrocytes forming articular cartilage are embedded in a vast amount of extracellular matrix having physical stiffness and elasticity, properties that support the mechanical load from bones and enable the flexible movement of synovial joints. Unlike chondrocytes that conduct the growth of long bones by forming the growth plate, articular chondrocytes show suppressed cell proliferation, unless these cells are exposed to pathological conditions such as mechanical overload. In the present study, we found that one of the members of the CCN family, CCN3, was significantly expressed in chondrocytes isolated from the epiphyseal head in developing rat synovial joints. Evaluation of the effect of recombinant CCN3 on those chondrocytes revealed that CCN3 promoted proteoglycan synthesis, whereas this factor repressed the proliferation of the same cells. These results suggest a critical role for CCN3 in the regulation of the biological properties of articular chondrocytes. © The International CCN Society 2011.

DOI： 10.1007/s12079-011-0135-1

A case report of palatoplasty for bilateral oblique facial clefts with atypical cleft palate Reviewed

YOKOTA Yusuke, AIKAWA Tomonao, YAMANISHI Tadashi, IIDA Seiji, MIMA Takashi, KOGO Mikihiko

Japanese Journal of Oral and Maxillofacial Surgery 57 ( 7 ) 424 - 428 2011.7

Histologic evaluation of human alveolar sockets treated with an artificial bone substitute material Reviewed

Mari Wakimoto, Takaaki Ueno, Azumi Hirata, Seiji Iida, Tara Aghaloo, Peter K. Moy

Journal of Craniofacial Surgery 22 ( 2 ) 490 - 493 2011.3

Language：English Publishing type：Research paper (scientific journal)

This study involved a histologic, enzyme histologic, immunohistologic, and three-dimensional microstructure evaluating the extent of osteogenesis and repair in the human alveolar extraction socket achievable with an artificial bone substitute. After tooth extraction in 7 patients, extraction sockets were filled with Mastergraft (15% hydroxyapatite, 85% β-tricalcium phosphate complex). Radiomicrographs and histologic examinations were performed on samples obtained during dental implant placement procedure. On micro-computed tomography, new bone was observed in all collected samples, and osteogenesis was observed to have taken place around the artificial bone substitute. Histologically, active osteogenesis was found throughout the region observed. Addition of new bone around the Mastergraft was observed, and osteoblast-like cells were present. Cells that had partially invaded the artificial bone included tartrate-resistant acid phosphate-positive and CD34-positive cells. These findings indicate that the Mastergraft artificial bone induced osteogenesis in the jawbone and seemed effective for repairing bone defects. Copyright © 2011 by Mutaz B. Habal, MD.

DOI： 10.1097/SCS.0b013e318208bacf

Preliminary study evaluating the accuracy of MRI images on CBCT images in the field of orthodontics Reviewed

Kiyoshi Tai, Jae Hyun Park, Kunio Hayashi, Yoshinobu Yanagi, Jun-Ichi Asaumi, Seiji Iida, Je-Won Shin

Journal of Clinical Pediatric Dentistry 36 ( 2 ) 211 - 218 2011.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Journal of Clinical Pediatric Dentistry

Objective: The purpose of this study was to explore the 3-dimensional (3D) accuracy of magnetic resonance imaging (MRI) on cone-beam computed tomography (CBCT) images after the registration of MRI images on CBCT images. Materials and Methods: Three Japanese adult females volunteered for this study. To transform digital imaging and communication in medicine (DICOM) data derived from MRI and CBCT images into polygon data, five software programs were used. CBCT and MRI images were obtained within one week, and both were registered by the iterative closest point (ICP) method. To assess the accuracy of the composite MRI-CBCT, the measurement errors of the MRI-CBCT were verified. Measurement values were compared using frontal and cephalometric soft-tissue landmarks. Differences were analyzed using the non-parametric Mann-Whitney U test. Results: There were no significant linear measurement errors (P 0.05) when the images were measured from the superimposed MRI-CBCT images. Conclusion: The MRI images attained from MRI-CBCT registration showed accurate 3D linear measurements.

DOI： 10.17796/jcpd.36.2.r7853hp574045414

A new modification for safer submental orotracheal intubation Reviewed

Hiroshi Hanamoto, Yoshinari Morimoto, Hitoshi Niwa, Seiji Iida, Tomonao Aikawa

Journal of Anesthesia 25 ( 5 ) 781 - 783 2011

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer-Verlag Tokyo

In patients in whom a tracheal tube cannot be inserted through the nostrils due to multiple facial trauma or hypoplasty of the nose, submental orotracheal intubation (SOI) is performed to avoid tracheostomy. We report a new modification for SOI to minimize the risk of apnea. A 20-year-old man was scheduled for sagittal split ramus osteotomy. As the patient had severe hypoplasia of the nose, SOI was planned. Following orotracheal intubation with a spiral tube (first tube), a submental tunnel was surgically created. A second tube that had been confirmed, in advance, to snugly fit into the proximal end of the first tube was passed into the submental tunnel via a polypropylene cylinder and connected between the first tube and the breathing circuit. After careful withdrawal of the second tube through the submental tunnel, the first tube was directly connected to the breathing circuit after removal of the second tube. Although this technique requires additional time, apnea time is minimal even in patients in whom withdrawal of the tracheal tube through the submental tunnel takes time, because the second tube forms a link between the first tube and the breathing circuit, making it possible to ventilate the patient throughout the procedure. © Japanese Society of Anesthesiologists 2011.

DOI： 10.1007/s00540-011-1204-6

Atypical Lipomatous Tumor of the Tongue: Report of a Case Reviewed

Norifumi Moritani, Tomohiro Yamada, Koichi Mizobuchi, Mari Wakimoto, Yoko Ikeya, Tatsushi Matsumura, Katsuaki Mishima, Seiji Iida

ACTA MEDICA OKAYAMA 64 ( 4 ) 257 - 261 2010.8

Language：English Publishing type：Research paper (scientific journal) Publisher：OKAYAMA UNIV MED SCHOOL

The term atypical lipomatous tumor (ALT) is synonymous with well-differentiated liposarcoma (WDL). This tumor occurs very rarely in the tongue. Thus, it is difficult to predict its prognosis. Although recurrence of ALT/WDL is thought to be unlikely after complete excision, long-term follow-up is necessary when considering the pathologic conditions of this tumor at other sites. Here, we report a case of an ALT of the tongue, with a review of the literature. A 68-year-old man was referred to our hospital because of a tumor on the left side of his tongue. Upon palpation, the tumor was 12mm in diameter, circumscribed, elastic and hard, well demarcated, movable, and painless. We diagnosed the lesion as a lipoma and extirpated the tumor under local anesthesia. Because the specimen was histopathologically diagnosed as an ALT, as a precaution, we excised an additional 5mm from the area surrounding the original tumor under general anesthesia. Three years after the operation, the tongue demonstrated good healing without paresthesia or dysfunction, and to date there has been no evidence of recurrence.

DOI： 10.18926/AMO/40134

Pilomatricoma in perioral region Reviewed

Tomotake Masuda, Seiji Iida, Yasuo Fukuda, Susumu Tanaka, Mari Namikawa, Mikihiko Kogo

Asian Journal of Oral and Maxillofacial Surgery 22 ( 1 ) 27 - 29 2010.7

Language：English Publishing type：Research paper (scientific journal)

Herein, we report a very rare case of pilomatricoma in the perioral region. A 27-year old Japanese female was referred to our clinic with a subcutaneous tumor in the angle of the left side of the mouth. The tumor was observed as a subcutaneous well-circumscribed and bony hard mass, without any changes of the skin surface, while a soft radiographic examination revealed a weak calcifying rounded mass. The tumor was extirpated using an intraoral approach, because of patient request. During the operation, the tumor was found to be partly attached to the surface skin, though easily removed from the surrounding tissue. The tumor was a rounded calcifying mass, 13. mm in diameter, and histologically diagnosed as a pilomatricoma. © 2010 Asian Association of Oral and Maxillofacial Surgeons.

DOI： 10.1016/j.ajoms.2009.05.003

MR画像で継時的変化を観察した顎関節滑膜性軟骨腫症の1例

榎本明史, 飯田征二, 足立忠史, 相川友直, 中原寛和, 濱田傑, 古郷幹彦

日本顎関節学会雑誌 22 ( Suppl. ) 109 - 109 2010.7

埋伏歯を伴い上顎洞内に位置した限局性骨性異形成症の1例

増田智丈, 磯村恵美子, 沢井奈津子, 岸野万伸, 飯田征二, 古郷幹彦

日本口腔外科学会雑誌 56 ( 3 ) 194 - 198 2010.3

Language：Japanese Publisher：(公社)日本口腔外科学会

症例は45歳女性で、1年前より左側上顎臼歯部に時折違和感を自覚していたが放置した。歯科治療で撮影されたパノラマX線で左側上顎洞内のX線不透過像を指摘された。顔貌は左右対称で、左側上顎眼窩下部に圧痛等の異常所見は認めなかった。左側上顎歯肉部に膨隆や腫脹、発赤等の異常所見を認めなかった。左上6、左上7は電気歯髄診断で生活反応を認めなかった。パノラマX線では左上678相当部の上顎洞底より左側上顎洞内に突出した類円形の塊状のX線不透過像が認められた。CTでは左側上顎洞内に上顎洞底から外向性に突出し上顎洞前壁、側壁、後壁と接する病変を認め、病変の内部のdensityは不均一であった。また、病変内部に歯を認めた。左側上顎骨腫瘍と診断し全身麻酔下に摘出術を施行した。病理組織学的所見は病変の内部に埋伏歯を認め、埋伏歯を取り囲むように塊状の不規則な形態の硬組織が認められた。硬組織はセメント質様、或いは骨様で、線維組織は細胞成分が豊富であった。術後経過は良好で術後6ヵ月現在、再発を認めていない。

口腔扁平上皮癌の遠隔成績に与える予後因子リンパ節転移を中心に

大倉正也, 平沼勉, 鏡内肇, 沢井奈津子, 飯田征二, 石井庄一郎, 相川友直, 古郷幹彦

日本口腔科学会雑誌 59 ( 2 ) 68 - 78 2010.3

A case of heterotopic gastrointestinal sublingual cyst Reviewed

Sawai N, Iisa S, Aikawa T, Kishino M, Tsujimoto I, Kogo M

Japanese Journal of Oral and Maxillofacial Surgery 55 ( 12 ) 644 - 648 2009.12

Regulation of trigeminal respiratory motor activity in the brainstem. Reviewed

Koizumi H, Nomura K, Yokota Y, Enomoto A, Yamanishi T, Iida S, Ishihama K, Kogo M

Journal of dental research 88 ( 11 ) 1048 - 1053 2009.11

Computed Tomography Followed by Ultrasound Examination Improves Detection of Regional Metastases in Patients with Squamous Cell Carcinoma of the Tongue

YOSHIMURA SAWAI Natsuko, OKURA Masaya, TANAKA Susumu, AIKAWA Tomonao, SASAI Tadashi, IIDA Seiji, MASUDA Tomotake, ISHII Shoichiro, FURUKAWA Souhei, KOGO Mikihiko

The Journal of Osaka University Dental Society 54 ( 1 ) 9 - 16 2009.10

Facial frontal morphological changes related to mandibular setback osteotomy using cephalograms. Reviewed International journal

Katsuhiko Amano, Takakazu Yagi, Seiji Iida, Tomonao Aikawa, Takashi Yamashiro, Kenji Takada, Mikihiko Kogo

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 37 ( 7 ) 412 - 6 2009.10

Language：English Publishing type：Research paper (scientific journal)

AIM: The purpose of this study was to examine morphological changes of the mandibular region using frontal cephalograms following bilateral sagittal split osteotomy (BSSO) for mandibular setback. Furthermore, we compared the stability between screw and plate fixation. METHODS: Pre and postoperative frontal cephalograms were taken of 26 patients. Parameters, Angle "A" which is formed by constructed lines along the mandibular ramus, and mandibular width at the angle were calculated. The subjects were analyzed according to the types of bony fixation, whether by screws or plates. RESULTS: Angle "A" and mandibular angular width of total numbers did not widely change at early period following operation. Late postoperatively, mandibular width of total numbers decreased in conjunction with increasing Angle "A". When comparing the parameters between screw and plate groups, the plate group showed a decrease of Angle "A" as an early change. Late postoperatively, the plate group showed an increase of Angle "A" and a decrease of mandibular width, while the screw group had smaller changes. CONCLUSION: We demonstrate postoperative inclination of mandibular lower ramus towards the facial midline. We suggest that the types of rigid fixation have an influence on frontal skeletal morphology, namely that screw fixation has higher stability.

DOI： 10.1016/j.jcms.2009.04.012

A case of giant epulis osteoplastica with a sequestrum

MASUDA Tomotake, TANAKA Noriaki, IIDA Seiji, SAWAI Natsuko, OGURA Takafumi, KOGO Mikihiko

Japanese Journal of Oral and Maxillofacial Surgery 55 ( 9 ) 453 - 457 2009.9

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

Epulis osteoplastica is a rare disease. We report a case of giant epulis osteoplastica containing a largesequestrum. A 63-year-old man was referred to our clinic because of a painless swelling on the left mandibularalveolus. Intraoral examination revealed an elastic hard tumor with a normal surface in the left lower molar region.Radiographic examination showed a large radiopaque mass separate from mandibular bone. Gingival tumor excisionwas performed with the patient under general anesthesia. The excised specimen measured 50 X 38 X 28mm and contained the bony mass. Histopathologically, the lesion was diagnosed as epulis osteoplastica with asequestrum. The patient was followed up for 4 years after the operation, without any recurrence.

DOI： 10.5794/jjoms.55.453

Other Link： https://jlc.jst.go.jp/DN/JALC/00338247726?from=CiNii

Mandibular fractures in severely developmentally disabled persons Reviewed

Yoshiko Idoji, Kohji Ishihama, Seiji Iida, Hiromichi Yamanishi, Mikihiko Kogo

Journal of Trauma - Injury, Infection and Critical Care 66 ( 4 ) E46 - E49 2009.4

Widening a narrow posterior mandibular alveolus following extirpation of a large cyst: a case treated with a titanium mesh-plate type distractor. Reviewed

Aikawa Tomonao, Iida Seiji, Senoo Hitomi, Hori Kazuhiro, Namikawa Mari, Okura Masaya, Ono Takahiro

Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106 ( 5 ) e1 - e7 2008.11

Language：English Publishing type：Research paper (scientific journal)

Vertical alveolar augmentation by distraction osteogenesis has become a standard pretreatment of dental implants due to the main benefit of lack of donor site complications, and many reports have shown its benefit with various types of alveolar distractors. However, autogenous bone transplantation and/or guided bone regeneration techniques are still the standard treatment for correcting a narrow alveolar ridge because of few commercially available distractors for alveolar widening. In this article, we treated a case by a mesh-plate type of alveolar widening distractor for a narrow posterior mandibular alveolar ridge after extirpation of a large jaw cyst.

DOI： 10.1016/j.tripleo.2008.07.006

Nasolabial cyst in a patient with cleft lip and palate Reviewed

T. Aikawa, S. Iida, Y. Fukuda, Y. Nakano, Y. Ota, K. Takao, M. Kogo

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 37 ( 9 ) 874 - 876 2008.9

Language：English Publishing type：Research paper (scientific journal) Publisher：CHURCHILL LIVINGSTONE

Nasolabial cysts are rare non-odontogenic cysts that occur beneath the ala nasi, and debate about their complicated, unique pathogenesis continues. It is widely accepted that these lesions originate from the anlage of the nasolacrimal duct; however, some still think that nasolabial cysts arise from fissural cysts. The authors report a patient with a nasolabial cyst who also had a unilateral cleft lip and palate. This unusual finding may indicate a different origin for nasolabial cysts than what has been accepted in the past.

DOI： 10.1016/j.ijom.2008.04.016

摂食障害が誘因と考えられた口蓋壊死性唾液腺炎の1例

原田丈司, 相川友直, 川嵜康大, 飯田征二, 岸野万伸, 古郷幹彦

日本口腔科学会雑誌 57 ( 3 ) 311 - 314 2008.7

Language：Japanese Publisher：(NPO)日本口腔科学会

26歳女。口蓋正中部疼痛を主訴とした。既往としてパニック障害、うつ病があり、25歳時より摂食障害を認め、過食と自己誘発性嘔吐を繰り返していた。右側口蓋に周囲硬結を伴う腫脹を認め、その中央部に壊死を伴う潰瘍を認めて口蓋悪性腫瘍を疑った。MRIでは右側口蓋にびまん性の腫脹を伴う境界明瞭な病変を認め、T1強調像で低信号、T2強調像で高信号を示した。潰瘍の生検を行い壊死性唾液腺炎と診断し、潰瘍にエレース軟膏とプロスタンディン軟膏を混和したガーゼを塗布し、保護床を装着して経過観察を行った。潰瘍は治癒傾向を示したが、生検6日後に左側口蓋に新たな潰瘍が出現した。右側病変と類似していたため同様の処置を行い、1ヵ月後に潰瘍は消失し、また経過観察中に過食や自己誘発性嘔吐も改善した。病理組織学的所見で小唾液腺の広範囲な腺房壊死や導管由来の扁平上皮化生を認めたが、粘液細胞の扁平上皮化生は認めず、腺房細胞周囲での著しい肉芽形成や炎症細胞浸潤も認めなかった。

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2008&ichushi_jid=J01072&link_issn=&doc_id=20080814280010&doc_link_id=%2Fcp8stoma%2F2008%2F005703%2F011%2F0311-0314%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcp8stoma%2F2008%2F005703%2F011%2F0311-0314%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

顎矯正手術により長期間咬合の安定が得られた末端肥大症の1例

相川友直, 太田之博, 飯田征二, 松岡裕大, 高尾香名, 古郷幹彦

日本口腔外科学会雑誌 54 ( 4 ) 234 - 238 2008.4

Language：Japanese Publisher：(公社)日本口腔外科学会

41歳女。下垂体腺腫と診断され経蝶形骨洞下垂体腫瘍摘出術を受け、以降末端肥大症の改善目的に持続性ソマトスタチンアナログの継続的投与を受けていた。今回、末端肥大症に伴う不正咬合および下顎前歯部歯間離開の改善目的に当科紹介となった。顔貌所見は顔面高および幅ともに大きく、前額部は突出し、眉部、眼窩外側縁は隆起していた。口腔内所見は舌は肥大し、睡眠時にいびきを伴っていた。上顎中切歯間と下顎前歯部に歯間離開を認め、上下顎中切歯ではover jetが-5mm、over biteが1mmを示し、上下第一大臼歯はIII級の対向関係にあった。側面セファロX線規格写真ではトルコ鞍の風船様拡大を認め、セファロ分析では骨格性下顎前突症を示した。末端肥大症に伴う骨格性下顎前突症および巨舌症と診断し、術前矯正治療後、下顎枝矢状分割術による顎矯正手術および舌縮小術を施行した。術後経過は良好で、術後4年4ヵ月のセファロX線写真分析で良好な下顎位と咬合を認めた。

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2008&ichushi_jid=J01073&link_issn=&doc_id=20080430380003&doc_link_id=10.5794%2Fjjoms.54.234&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.54.234&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

An Uncommon Cleft Subtype of Unilateral Cleft Lip and Palate

T. Yamanishi, C. Kobayashi, I. Tsujimoto, H. Koizumi, S. Miya, Y. Yokota, R. Okamoto, S. Iida, T. Aikawa, H. Kohara, J. Nishio, M. Kogo

Journal of Dental Research 87 ( 2 ) 164 - 168 2008.2

Publishing type：Research paper (scientific journal) Publisher：SAGE Publications

The finding that the vomer plays a crucial role in maxillary growth suggests that the bilateral cleft configuration of unilateral cleft lip and palate (UCLP), in which the vomer is detached from the non-cleft-side secondary hard palate, negatively influences palatal development, and this hypothesis was tested. Sixty persons with complete UCLP, including those with the vomer detached from (n = 30, b-UCLP) and attached to (n = 30, u-UCLP) the secondary hard palate, were analyzed morphologically, with the use of cast models taken at 10 days, 3 mos, and 12 mos of age. The anterio-posterior palatal length at 12 mos of age in those with b-UCLP was significantly shorter than that in those with u-UCLP, by 8.7% (p < 0.05). In addition, palatal width development in the first year in those with b-UCLP was also significantly retarded. These results suggest that the uncommon bilateral cleft subtype in UCLP should be included in the cleft classification.

DOI： 10.1177/154405910808700212

Other Link： http://journals.sagepub.com/doi/full-xml/10.1177/154405910808700212

A immunohistochemical study of the peripheral ameloblastoma Reviewed

M. Kishino, S. Murakami, M. Yuki, S. Iida, Y. Ogawa, M. Kogo, S. Toyosawa

Oral Diseases 13 ( 6 ) 575 - 580 2007.11

Publishing type：Research paper (scientific journal)

Aim: Peripheral ameloblastoma (PA) is a rare variant of ameloblastoma occurring in the extraosseous region. With regard to the histogenesis of the tumor, two major sources of origin are considered: odontogenic epithelial remnants and the gingival epithelium. In this study, we examined the immunohistochemical profiles of cytokeratins (CKs) and Ki-67 labeling index (LI) of PAs, and discuss the histogenesis and the biologic behavior of the PA. Materials and methods: Eight cases of PA were retrieved from the pathology files of 212 cases of ameloblastoma that had been registered at our hospital. Immunohistochemical staining was performed in seven cases using monoclonal antibodies of six CKs (7, 8, 13, 14, 18, and 19) and Ki-67. Results: All cases of PA expressed CK13, 14, and 19. CK18 was positive staining in six cases, and CK8 in five cases. This staining pattern was similar to that in intraosseous ameloblastomas (IAs). The mean of Ki-67 LI of PAs (1.91%) was significantly lower than that of IAs (4.82%) (P = 0.002). Conclusion: We consider that the PA originates from odontogenic epithelial remnants rather than from the gingival epithelium, and the Ki-67 LI of the tumor is a good prognostic indicator. © 2007 The Authors.

DOI： 10.1111/j.1601-0825.2006.01340.x

口蓋裂を伴う両側性斜顔面裂の1例

相川友直, 宮成典, 足立忠文, 山西整, 飯田征二, 古郷幹彦

日本口腔外科学会雑誌 53 ( 10 ) 603 - 607 2007.10

Language：Japanese Publisher：(公社)日本口腔外科学会

1歳2ヵ月、メキシコ人男児。術前所見では右側にTessier No.4顔面裂、左側にNo.5顔面裂(それぞれNo.4 cleft、No.5 cleft)、左側に顎裂部に連続する索状組織を認めた。右眼は開眼不能であり、角膜は肥厚、混濁し、失明していた。生後8ヵ月時に右側斜顔面裂の形成手術、左側の索状組織切除術を施行されたが、審美的・機能的改善が得られなかった。当科入院時、右側披裂部に手術後瘢痕、上唇の披裂を認め、下眼瞼は下方に強く牽引され閉眼不能であった。CTでは右側小眼球症を認め、右側眼窩内容積は左側に比べ狭小であった。右側の骨披裂は乳犬歯相当部から眼窩下縁にかけて、左側の骨披裂は第二乳臼歯相当部から眼窩下縁にかけて存在した。口蓋裂を伴う両側性斜顔面裂、右側No.4 cleft、左側No.5 cleftと診断し、No.4 cleftには連続Z形成術を応用し、No.5 cleftには口角形成術(松矢法)とZ形成術を応用した形成術を行った。術後経過は良好で、白唇、口角、頬部の良好な形態を確認した。

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2007&ichushi_jid=J01073&link_issn=&doc_id=20071025390004&doc_link_id=10.5794%2Fjjoms.53.603&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.53.603&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

低位骨性癒着大臼歯症例に対するSingle-tooth dento-osseous osteotomyならびにCorticotomy 多数歯骨性癒着症例の治療経験

山澤通邦, 飯田征二, 小田佳朗, 磯村恵美子, 前川裕子, 相川友直, 太田之博, 松岡裕大, 古郷幹彦

大阪大学歯学雑誌 52 ( 1 ) 5 - 9 2007.10

Language：Japanese Publisher：大阪大学歯学会

20歳男。上下左右の大臼歯の骨性癒着を主訴とした。口腔内所見では両側上下顎第2小臼歯、第1大臼歯が低位であり、同部で咬合を認めなかった。X線で両側下顎第2小臼歯、第1大臼歯に歯根膜腔を認めず、骨性癒着を疑った。両側上下顎第1大臼歯、第1小臼歯の低位骨性癒着歯と診断し、右側上下顎第1大臼歯と左側上顎第1大臼歯に対しCorticotomyを施行し、顎間ゴムの矯正装置により咬合誘導を行った。しかし、初回の処置だけで移動を確認したのは右側上顎第1大臼歯のみであり、それ以外の2歯については再手術による海綿骨の離断を追加した。残りの左側下顎第1大臼歯に対しては、Single-tooth dento-osseous osteotomyを施行し、顎間ゴムの矯正装置により咬合誘導を行った。4歯とも移動を確認し、術後4ヵ月のX線で歯根膜スペースの拡大から歯牙の脱臼を認め、術後6ヵ月には歯槽骨の良好な治癒状況を認め、左右臼歯部の咬合関係が回復した。

両側に発生した乳臼歯歯根嚢胞の1例と乳歯歯根嚢胞の臨床的検討

原田丈司, 相川友直, 川嵜康大, 山澤通邦, 飯田征二, 古郷幹彦

大阪大学歯学雑誌 51 ( 2 ) 65 - 68 2007.4

Language：Japanese Publisher：大阪大学歯学会

11歳男。学校検診で齲蝕を指摘され、某歯科医院を受診したところパラノラマX線検査で両側下顎第二乳臼歯根尖部にX線透過像を認められ当科に紹介された。諸検査により後続永久歯が先天的に欠損した乳臼歯歯根嚢胞と診断した。局所麻酔下に抜歯+嚢胞摘出術を施行し、術後経過良好であった。当院で1985〜2005年に経験した乳歯歯根嚢胞14例について臨床的検討を行った。男女比は1.8:1、初診時年齢は6〜13歳(平均9.6歳)であった。診断契機は「パノラマX線で偶然発見」が最も多く8例(57.1%)、次いで「顎骨の腫脹」4例(28.6%)、「疼痛」2例(14.3%)の順であった。治療法は抜歯+嚢胞摘出が9例(64.3%)、抜歯+開窓術が5例(35.7%)であった。

A case of osteonecrosis of the mandible caused by bisphosphonates

KISHI Naoko, ADACHI Tadafumi, KOIZUMI Hidehiko, IIDA Seiji, KOGO Mikihiko

Journal of Oral Surgery Society of Japan 53 ( 1 ) 28 - 32 2007.1

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

Bisphosphonates (BPs) are widely used for the management of hypercalcemia related to malignancy and bone metastases from breast cancer in Japan. We report a case of osteonecrosis of the jaw (ONJ) associated with a history of BPs therapy forthe management of bone metastases from breast cancer. A 69-year-old woman was referred to our department becaused of unhealed extraction sockets of the lower left premolar and first molar, which were removed at a dental clinic. CT scans of the mandible showed regions of mottled bone and sequestra, and a clinical diagnosis of ONJ was made. After conservative treatment with antibiotics and local minor curettage, the inflammatory symptoms almost completely disappeared. Dentists should be aware of this potentially serious complication in patients receiving long-term treatment with BPs.

DOI： 10.5794/jjoms.53.28

Other Link： https://jlc.jst.go.jp/DN/JALC/00289727506?from=CiNii

Sialolipoma of the hard palate. Reviewed

Sakai T, Iida S, Kishino M, Okura M, Kogo M

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 35 ( 6 ) 376 - 378 2006.7

Language：English Publishing type：Research paper (scientific journal) Publisher：BLACKWELL PUBLISHING

Sialolipoma is a new variant of salivary gland lipoma, which was first proposed by Nagao et al. (Histopathology 2001; 38: 30) in 2001. We report this rare case of sialolipoma in the hard palate. A 60-year-old Japanese woman was referred to our department complaining of a painless swelling on the right side of the hard palate. Intra-oral examination revealed a soft, elastic, dome-shaped mass with I cm in diameter located in the posterior part of the hard palate. Magnetic resonance imaging examination revealed high intensity on T-1-weighted image and iso-intensity on T-2-weighted image. Incisional biopsy revealed that the tumor was encapsulated by fibrous tissue, consisted of adipose tissue, and also contained normal salivary gland tissue peripherally. First diagnosed as an ordinary lipoma of the hard palate, the tumor was excised. According to the recent criteria of histologic findings of sialolipoma, we rediagnosed the tumor as sialolipoma of the hard palate.

DOI： 10.1111/j.1600-0714.2006.00409.x

A new attachment for proximal segment positioning for bimaxillary dysgnathic surgery--technical note. Reviewed International journal

Seiji Iida, Tobias Reuther, Tomonao Aikawa, Takayoshi Sakai, Masaya Okura

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery 34 ( 4 ) 217 - 9 2006.6

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The frequent insertion of self-tapping screws for securing the proximal positioning plate in bimaxillary osteotomy often cause loosening of screws and plate, which produces incorrect repositioning. In this article, a newly developed base-attachment for a T-shaped proximal positioning plate for bimaxillary osteotomy is presented. MATERIAL: The base-attachment set consists of a titanium base-attachment and two titanium tapped screws. The attachment has a shallow depression having the same shape as the basal part of the positioning plate. METHOD: The base-attachment is secured by self-tapping screws until the end of the procedure, and the T-shaped proximal positioning plate is placed and secured by two titanium-tapped screws. RESULT: By using this base-attachment, the T-shaped plate can be easily placed repeatedly without difficulty. CONCLUSION: This base-attachment set may be useful for the frequently repositioned proximal plate in bimaxillary osteotomy.

DOI： 10.1016/j.jcms.2006.01.002

A case of adult chickenpox with the first symptom in the oral cavity

INADA Yoshiki, IIDA Seiji, HARADA Takeshi, YAMANISHI Tadashi, KITAGAWA Taiji, KOGO Mikihiko

Journal of Oral Surgery Society of Japan 51 ( 10 ) 505 - 508 2005.10

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

Chickenpox is a common infection due to varicella-zoster virus (VZV), which generally occurs in childhood. However, the incidence of chickenpox in adults is increasing because of changes in the social environment. In this paper, we report a case of adult chickenpox with the first symptom in the oral cavity. A 32-year-old Japanese woman presented with palatal ulcerative lesions and many bullae on her skin. The first symptom was continuous spontaneous pain at the left upper molar, present for 15 days before her first visit. Intravenous and oral acyclovir was given for a clinical diagnosis of VZV infection. Although the serum antibody examination showed no evidence of VZV infection, the symptoms led to a diagnose of adult chickenpox.

DOI： 10.5794/jjoms.51.505

Other Link： https://jlc.jst.go.jp/DN/JALC/00376931236?from=CiNii

Long-term outcome and factors influencing bridging plates for mandibular reconstruction Reviewed

M Okura, ET Isomura, S Iida, M Kogo

ORAL ONCOLOGY 41 ( 8 ) 791 - 798 2005.9

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE BV

Vascularized bone grafts have become the preferred method of mandibular reconstruction. However, the technique is considered to increase both the operating time and blood loss, which might be associated with an increased morbidity and mortality. We conducted a retrospective analysis of 100 consecutive patients who underwent immediate bridging plate reconstruction. The median follow-up duration was 70 months. The 5-year overall survival rate was 69.9%. Cox multivariate analysis revealed that red blood cell transfusion was an independent prognostic factor for the overall survival. The plate survival with no complications was 62.2% at 5 years. Anterolateral defects and preoperative radiotherapy emerged as an independent adverse factor for plate survival. The use of bridging plates is an option for lateral mandibular reconstruction with no preoperative irradiation to avoid the risk from blood transfusion. (C) 2005 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.oraloncology.2005.03.006

Kimura's disease: report of a case with presentation in the cheek and upper eyelid. Reviewed International journal

Iida S, Fukuda Y, Ueda T, Sakai T, Okura M, Kogo M

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 63 ( 5 ) 690 - 693 2005.5

Morphological changes of regional lymph node in squamous cell carcinoma of the oral cavity. Reviewed

Okura M, Kagamiuchi H, Tominaga G, Iida S, Fukuda Y, Kogo M

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 34 ( 4 ) 214 - 219 2005.4

Ameloblastomatous calcifying odontogenic cyst in the mandible Reviewed

S Iida, T Ueda, T Aikawa, M Kishino, M Okura, M Kogo

DENTOMAXILLOFACIAL RADIOLOGY 33 ( 6 ) 409 - 412 2004.11

Language：English Publishing type：Research paper (scientific journal) Publisher：BRITISH INST RADIOLOGY

Ameloblastoma is one of the well-known odontogenic tumours that can be associated with calcifying odontogenic cysts (COCs), but only a few reports include detailed clinical and radiographic features. In this paper we demonstrate a case of large ameloblastomatous COC in the mandible. The radiographic examination revealed the presence of a multilocular cystic lesion in the right posterior part of the mandible containing the impacted lower second molar with remarkable expansion toward both lingual and buccal side. This feature was different from the general findings of COC and rather resembled that of ameloblastomas.

A case of mandibular prognathism by modified inverted L ramus osteotomy Reviewed

Thaniguchi Y, Nakahara H, Kohara H, Tanaka E, Iida S, Kogo M

JJOMS 50 ( 4 ) 227 - 230 2004.4

Neurilemmoma Originating from the Hypoglossal Nerve in the Floor of the Mouth

Çaǧri Delilbaşi, Hiroshi Kohara, Kana Takao, Seiji Iida, Mikihiko Kogo

Turkish Journal of Medical Sciences 34 ( 1 ) 73 - 75 2004

石灰化歯原性嚢胞10例の臨床的X線学的検討

上田貴史, 飯田征二, 吉岡秀郎, 田中晋, 古郷幹彦, 松矢篤三

日本口腔科学会雑誌 50 ( 5 ) 329 - 330 2001.9

当科で経験した仮骨延長術の2症例

金曙館, 古郷幹彦, 飯田征二, 田中晋, 大谷朋弘, 向井紀文, 森亮太, 松矢篤三, 社浩太郎, 高田健治

大阪大学歯学雑誌 45 ( 1 ) 38 - 39 2000.9

歯性上顎洞炎に関する臨床的・X線学的検討.(共著）

中山宝恵, 岡田元,飯田征二,古郷幹彦,松矢篤三

大阪大学歯学会雑誌 44 ( 2 ) 113 - 118 2000

口蓋帆付培養脳幹を用いた口蓋帆の呼吸性活動の解析

山西整, 古郷幹彦, 飯田征二, 浜口裕弘, 小泉英彦, 田中晋, 石浜孝二, 森厚行, 松矢篤三

日本口腔科学会雑誌 48 ( 6 ) 737 - 738 1999.11

The effect of the procedure of primary cheiloplasty and Hotz plate on symmetry of post operative nasal form in unilateral cleft lip and palate children

SENOO Hitomi, IIDA Seiji, KOGO Mikihiko, ADACHI Tadafumi, ISHII Shoichiro, SHIKATA Megumi, MATSUYA Tokuzo

44 ( 1 ) 9 - 14 1999

Open reduction of high condylar fractures with a vertical subcondylotomy technique and a new retractor for vertical subcondylotomy

IIDA Seiji, KOGO Mikihiko, MATSUYA Tokuzo, MIMA Takashi, SUGI Masakazu, NAKAHARA Hirokazu

Journal of Oral Surgery Society of Japan 44 ( 4 ) 412 - 414 1998

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

Open vertical osteotomy in the mandibular ramus is the one surgical option for the correction of mandible deformity. It is easy to assume that this procedure is useful for open reduction of condylar fractures. In this paper we describe a new systematic procedure for open reduction of high condylar fractures. The procedure involves vertical subcondylotomy and a new retractor for subcondylotomy to protect the mandibular neurovascular bundle.<BR>The major points of this operation are the use of vertical condylotomy, removal of the posterior border of the ramus and plating the condylar head with it, and accurate replacement of the posterior border of the ramus with mini plates prepared before osteotomy.

DOI： 10.5794/jjoms.44.412

Other Link： http://search.jamas.or.jp/link/ui/1998198548

Clinical observation of 146 cases of sports-related oral and maxillofacial fractures

IIDA Seiji, NOMURA Kimiko, SUGIURA Tsuyoshi, NAKASHIMA Masahiro, ADACHI Tadafumi, KOGO Mikihiko, MATSUYA Tokuzo

Journal of Oral Surgery Society of Japan 44 ( 10 ) 805 - 807 1998

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

In this study, we clinically observed 146 patients with sports-related oral and maxillofacial fractures treated at the First Department of Oral and Maxillofacial Surgery, Osaka University Faculty of Dentistry during the past 15 years. The results were as follows.<BR>Among 146 patients, 134 were male and 12 were female. Although 62.5% of the patients were 15 to 24 years of age, there was an annual trend toward a decrease in patients aged 15 to 19 years. The most common causative sport event was baseball (54 patients), followed by rugby football (26 patients) and soccer (15 patients). There was also a decrease in baseballrelated cases and an increase in soccer-related cases in recent years. Isolated mandibular fractures occurred in 92 patients, and the most common site was the mandibular angle, followed by the condyle and canine. Among 37 isolated midface fractures, the most common site was the zygomatic arch (14 patients).<BR>Baseball-related mandibular fractures had a high incidence of two-line fractures and fractures of the anterior portion of the mandibular body as compared with other events.

DOI： 10.5794/jjoms.44.805

Other Link： http://search.jamas.or.jp/link/ui/1999069467

New Surgical Procedure for Transverse Facial Cleft

IIDA Seiji, MATSUYA Tokuzo, KOGO Mikihiko, OKURA Masaya, FUJIMOTO Yoshiyuki, NAKAHARA Hirokazu

46 ( 4 ) 393 - 396 1997

Unilateral transverse facial cleft: A report of six cases

IIDA Seiji, KOGO Mikihiko, OKADA Gen, TANAKA Susumu, HIRANUMA Tsutomu, ISHIHAMA Kouji, TOMINAGA Gyou, TAKEDA Munehiro, MATSUYA Tokuzo

Journal of Oral Surgery Society of Japan 43 ( 4 ) 373 - 375 1997

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

We report six cases of unilateral transverse facial cleft. Five patients were male and one was female. One case was diagnosed as solitary macrostomia, and other cases had accessory ears. Among latter cases, one also suffered from microtia and was diagnosed as the first and second branchial syndrome. Another case was diagnosed as Goldenhar syndrome because of the presence of epibulbar dermoid. The other cases were diagnosed as the first branchial syndrome.

DOI： 10.5794/jjoms.43.373

Other Link： http://search.jamas.or.jp/link/ui/1997193080

A Case of Bilateral Parotid Sialolithiasis.

SAKAI Takayoshi, IIDA Seiji, TAKEDA Munehiro, NISHIMURA Norihiko, KIMURA Tetsuo

J.Jpn.Stomatol.Soc 46 ( 2 ) 187 - 190 1997

Language：Japanese Publisher：Japanese Stomatological Society

Sialolith usually occurs in the submandibular gland and its occurrence in the parotid gland is relatively rare. Especially the occurrence of sialoliths in the bilateral parotid gland is very rare and only three cases of such a case have been reported. In this paper, a case of sialolithiasis occurring in the bilateral parotid gland was reported.<BR>The patient, a 65-year-old Japanese male, visited our clinic complaining of swelling of the right buccal mucosa including the orifice of the parotid duct. Roentogen examination revealed the presense of sialoliths in the right parotid duct and the deep lobe of the left parotid gland. Extirpation of the sialoliths of the right parotid duct was performed under local anesthesia, and 6 sialoliths of 2 mm or less in diameter were observed. Though extirpation of the left sialolith was not performed because of lack of objective and subjective symptoms, long-term follow up is considered nessesary.

DOI： 10.11277/stomatology1952.46.187

Open reduction using a Martin-Eckelt^【〇!R】lag screw system for condylar process fractures

IIDA Seiji, NISHIMURA Norihiko, TAKEDA Munehiro, OKURA Masaya, HAMAGUCHI Munehiro, SAKAI Takayoshi, OKIMURA Makoto, KIMURA Tetsuo

Journal of Oral Surgery Society of Japan 43 ( 12 ) 927 - 929 1997

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

Eight patients with unilateral condylar fractures of the mandible who were treated at our clinic by Martin-Eckelt lag screw osteosynthesis are described.<BR>The patients were aged 14 to 78 years. There were 4 males and 4 females. Four patients had fractures of the base of the condylar process, and four had fractures of the condylar neck. Two patients had no dislocation, four had dislocation, and two had luxation. Clinical examinations 6 months after primary operation showed that mouth opening was not less than 40mm in any patient. Radiographic examinations revealed a correct position and normal form of the condylar head in six patients, but resorption of the condylar head was found in two patients. These two patients required extirpation of condylar head for reduction. Since the use of a lag screw decreases the supply of nutrients from the bone marrow of mandibular ramus to the condylar head, the condylar head should not be removed from the surrounding soft tissue during operation.

DOI： 10.5794/jjoms.43.927

Other Link： http://search.jamas.or.jp/link/ui/1998090003

Unified velopharyngoplasty for the management of recurrence of velopharyngeal incompetence after pharyngeal flap surgery

TACHIMURA Takashi, HARA Hisanaga, WADA Takeshi, IIDA Seiji, KOGO Mikihiko, MATSUYA Tokuzo

Journal of Oral Surgery Society of Japan 42 ( 3 ) 320 - 322 1996

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

Pharyngeal flap surgery is used in the prevention of hypernasality and the devel-opment of articulation disorders that are associated with velopharyngeal incompetence after primary palatal closure. However, surgery may result in failure when the level of the pharyngeal flap base is not determined properly with relation to that of velopharyngeal move-ment or when the flap shrinks because of scar contraction through prolonged exposure of its raw surface. This report describes one patient who had suffered from recurrence of velopharyngeal incompetence after pharyngeal flap surgery. Lateral cephalographic and nasopharyngeal fiberscopic examinations identified the cause of flap atrophy to be marked scar contraction, and the flap base was remarkably lower than the level of velopharyngeal closure in the patient. Unified velopharyngoplasty was newly performed on the basis of find-ings obtained from lateral cephalographic and nasopharyngeal fiberscopic examinations to correct the recurrence of velopharyngeal incompetence in the patient. One year postoperatively, complete closure of the velopharynx in coordination of the flap during speech was confirmed by nasopharyngeal fiberscopy.

DOI： 10.5794/jjoms.42.320

Other Link： http://search.jamas.or.jp/link/ui/1996193738

Two cases of calcifying epithelioma arising at the periauricular region

NISHIMURA Norihiko, IIDA Seiji, TAKEDA Munehiro, SAKAI Takayoshi, YAMAOKA Hitoo, KIMURA Tetsuo

Journal of Oral Surgery Society of Japan 42 ( 7 ) 693 - 695 1996

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

We reported two cases of calcifying epithelioma arising in subcutaneous tissue around the auricle. One case was in a 11-year-old Japanese girl who visited our clinic complaining of a mass at the left preauricular region, which had been present since the age of 3. Radiographic examination revealed the presence of calcification measuring 10×8 mm in diameter. Enucleation was performed, and a histopathological diagnosis of a calcifying epithelioma was made. Histopathologically, the tumor was composed mainly of shadow cells, and bone formation was also observed. The other case was in a 52-year old Japanese man, who visited our clinic complaining of a mass at the left side of the neck. The tumor was located at the subauricular region, and the surface of the tumor had undergone partial necrosis. The tumor was enucleated with the surrounding granulation tissue. The histopathological diagnosis was a calcifying epithelioma. Histopathological examination revealed the tumor to be composed of basophilic cells and shadow cells; calcifications were also observed.<BR>The postoperative course of both patients was uneventful, with no evidence of recurrence.

DOI： 10.5794/jjoms.42.693

Other Link： http://search.jamas.or.jp/link/ui/1997075903

当科で入院加療を行った顎顔面骨骨折の臨床統計的観察(共著)

西村則彦 , 飯田征二 , 竹田宗弘 , 阪井丘芳 , 木村哲雄

大阪大学歯学雑誌 41 ( 1 ) 232 - 239 1996

Obstructive Sleep Apnea Syndrome Case Report Occurring after Primary Palatal Closure Operation

HAMAGUCHI Munehiro, KOGO Mikihiko, IIDA Seiji, TAKEMURA Hitomi, ISHII Syoichiro, TANAKA Susumu, YASUI Yasunobu, MATSUYA Tokuzo

21 ( 3 ) 150 - 155 1996

A case of hemifacial microsomia with cleft palate

UCHIDA Yoshiyasu, IIDA Seiji, KOGO Mikihiko, OKADA Gen, TACHIMURA Takashi, MATSUYA Tokuzo

Journal of Oral Surgery Society of Japan 42 ( 4 ) 457 - 459 1996

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

Hemifacial microsomia is defined as a condition affecting primarily aural, oral, and mandibular development and its clinical features may vary. In this paper we report a case of hemifacial microsomia with cleft palate. A Japanese girl 8 months of age was referred to our clinic for the treatment of cleft palate. Clinically, she had hypoplasia and inferior displacement of the left auricle, stenosis of the external auditory canal, a hypoplastic mandible, and facial palsy at the left side of the lower lip. There was no significant asymmetry of the maxillary dental arch or soft palate, and the left side of the soft palate showed mild hypokinesia. Palatoplasty with a push-back method was performed under general anesthesis at the age of 1 year 5 months. A few reports have shown a trend toward velopharyngeal insufficiency in hemifacial microsomia due to hypoplastic palatal muscles and poor neural control of these muscles. In the future, comprehensive speech therapy will be required in this patient.

DOI： 10.5794/jjoms.42.457

Other Link： http://search.jamas.or.jp/link/ui/1996234675

Evaluation of Nutritional Estimation during Induction Chemotherapy with Peplomycin, Vincristine, Mitomycin C and Cisplatinum on Oral Squamous Cell Carcinomas

IIDA Seiji, SHIRASUNA Kanemitsu, ADACHI Tadafumi, OGURA Takafumi, KOGO Mikihiko, HIRANUMA Tsutomu, MATSUYA Tokuzo

45 ( 1 ) 67 - 71 1996

口腔外科領域におけるトスキサシン錠の(トシル酸トスフロキサシン)の臨床的検討(共著)

藤本佳之, 綿谷和也, 林堂安貴

歯界展望 85 ( 6 ) 1479 - 1486 1995

Localization and clinical symptoms of submandibular salivary stones

IIDA Seiji, KOGO Mikihiko, OKURA Masaya, AIKAWA Tomonao, SHIKATA Megumi, ISHII Shoichiro, TANAKA Susumu, TAKEMURA Hitomi, KUBO Shigemasa, MATSUYA Tokuzo

Journal of Oral Surgery Society of Japan 41 ( 10 ) 890 - 892 1995

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

We clinically observed patients with sialolithiasis of the submandibular gland who visited our department during the past 10 years (January 1984 to December 1993). The following results were obtained.<BR>One hundred forty-six cases of sialolithiasis of the submandibular gland were diagnosed. The highest proportion of patients were in their 3rd decade of life, and the ratio of men to women was 1 to 1.4. The most common site of occurrence was within the submandibular duct (84.2%), and larger sialoliths tended to occur in the gland and the transitional portion. The main clinical symptoms of submandibular sialolithiasis were swelling and/or tenderness of the gland, and these symptoms tended to occur on the gland side. Infection of the oral cavity tended to occur on the orifice side.

DOI： 10.5794/jjoms.41.890

Other Link： http://search.jamas.or.jp/link/ui/1996136698

Sialolithiasis of the minor salivary glands of the lip : Report of 3 cases

IIDA Seiji, SHIRASUNA Kanemitsu, ISHII Shoichiro, MORIOKA Shigeyuki, UCHIDA Yoshiyasu, SHIKATA Megumi, NAKASHIMA Masahiro, AIKAWA Tomonao, KOIZUMI Hidehiko, KUBO Shigemasa, MATSUYA Tokuzo

Journal of Oral Surgery Society of Japan 41 ( 3 ) 263 - 265 1995

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

Sialolithiasis mainly occurs in the submandiblar gland and its occurrence in minor salivary glands is very rare. In this paper we report three cases of sialolithiasis occurring in the minor salivary glands of the lip. Two cases occurred in the upper lip and one in the lower lip. Histopathologically, the case in the lower lip consisted of more than six calcified masses in the minor salivary gland tissue.

DOI： 10.5794/jjoms.41.263

Other Link： http://search.jamas.or.jp/link/ui/1995233309

頬部リンパ管腫再発症例の1治験例

大阪大学歯学雑誌 40 ( 2 ) 452 1995

口蓋裂を伴ったKlippel-Feil症候群の1例(共著)

大阪大学歯学雑誌 40 ( 1 ) 346 1995

A case of benign fibrous histiocytoma of the mandible.

IIDA Seiji, SUGI Masakazu, UCHIDA Yoshiyasu, TSUDA Takashi, KOHARA Hiroshi, MATSUYA Tokuzo

Journal of Oral Surgery Society of Japan 40 ( 1 ) 209 - 211 1994

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

Benign fibrous histocytoma is a well-established soft tissue neoplasm, and the occurrence of this lesion in the oral cavity is rare. Only 3 cases of this lesion arising centrally in the mandible have been reported in the literature. In this paper, we reported a patient with benign fibrous histiocytoma of the mandible.<BR>A 42-year-old Japanese woman was referred to our department complaining of swelling on the lingual side of the right mandibular body in November 1987. Radiographic examination demonstrated a illdefined radiolucent lesion in the right body of the mandible extending from 7 to the ramus. We performed segmental resection of the mandible in March 1988. A solid yellowish lesion was observed in the mandible body, and partial destruction of the lingual palate was found. Histopathologically, the lesion was composed of spindle-shaped figroblastic cells and histiocytic cells. The histiocytic cells showed negative staining for S-100 protein and positive staining for a-1 antitrypsin. Based on these clinical and histopathological findings, the lesion was diagnosed as benign fibrous histiocytoma. The postoperative course was good and no signs of recurrence have been seen almost 6 years and 4 months after operation.

DOI： 10.5794/jjoms.40.209

Other Link： http://search.jamas.or.jp/link/ui/1994186632

Pathological analysis of 171 cases clinically diagnosed as oral leukoplakia by the WHO classification.

IIDA Seiji, SHIRASUNA Kanemitsu, SUGI Masakazu, HAYASHIDO Yasutaka, KOGO Mikihiko, UCHIDA Yoshiyasu, YOSHIOKA Hideo, HIRANUMA Tsutomu, SHIKATA Megumi, SUGIURA Tsuyoshi, MATSUYA Tokuzo, ISHIDA Takeshi

Journal of Oral Surgery Society of Japan 40 ( 12 ) 1290 - 1292 1994

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

This study investigated the correlation between clinical and histopathological findings in 171 cases clinically diagnosed as oral leukoplakia. Histopathological examination revealed squamous cell carcinoma in 14 cases, leukoplakia with epithelial dysplasia in 68 cases, and hyperkeratosis without epithelial dysplasia in 89 cases. According to the grade of epithelial dysplasia, the leukoplakias were classified into mild, moderate, severe epithelial dysplasia and carcinoma in situ, which included 49, 14, 3 and 2 cases, respectively. High grades of epithelial dysplasia were mainly observed on the lateral edge of the tongue or the oral floor. There was a close correlation between the clinical appearance of lesions and a high grade of dysplasia; the majority of the cases with high grades of dysplasia or with early invasive carcinoma clinically showed erosive-type lesions.

DOI： 10.5794/jjoms.40.1290

Other Link： http://search.jamas.or.jp/link/ui/1995189697

上気道の気流知覚が口蓋帆挙筋活動に及ぼす影響

飯田征二

大阪大学歯学雑誌 38 ( 2 ) 414 - 428 1993

A case of adult xanthogranuloma of the upper lip.

TSUDA Takashi, MACHIDA Junji, IIDA Seiji, UCHIDA Yoshiyasu, MATSUYA Tokuzo

Journal of Oral Surgery Society of Japan 38 ( 12 ) 1919 - 1920 1992

Small premaxilla in cleft lip and palate patients suffered with congenital hypopituitarism.

IIDA Seiji, KOGO Mikihiko, UCHIDA Yoshiyasu, YASUI Yasunobu, FUJIMOTO Yoshiyuki, MATSUYA Tokuzo

Journal of Oral Surgery Society of Japan 38 ( 6 ) 818 - 823 1992

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

Four cases of pituitary hormone deficiency with cleft defects of the lip and palate were reported. In all cases, we noticed the small premaxilla, but there was no cerebral anomaly such as holoprosencephaly.The present report suggests the small premaxilla is a sign of the pituitary hormone deficiency in cleft lip and palate children.This clinical feature would be useful for diagnosis of the pituitary hormone deficiency.

DOI： 10.5794/jjoms.38.818

Other Link： http://search.jamas.or.jp/link/ui/1993108987

有床義歯に接触する口腔粘膜に生じた腸瘍の3例(共著)

逓信医学 43 ( 2 ) 99 1991

A case of recurrent ameloblastoma with invasion to adjacent soft tissue.

IIDA Seiji, INOUE Kazuo, KOGO Mikihiko, HAMAMURA Yasushi, MATSUYA Tokuzo

Journal of Oral Surgery Society of Japan 37 ( 2 ) 398 - 402 1991

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

Conservative treatment for ameloblastoma frequently produces recurrence. But even after radical treatment for this lesion, recurrence may occur. Recurrence in such cases is most likely due to involvement of adjacent soft tissue structures by tumor tissue.<BR>In such cases of recurrence after conservative treatment, ameloblastoma proliferate immediately in soft tissue and gingiva. We performed segmental resection of mandible bone involving adjacent soft tissue and one-stage microsurgical reconstruction using radial forearm skin flap.

DOI： 10.5794/jjoms.37.398

Hotz口蓋床を用いた唇顎口蓋裂患者の体重増加(共著)

日本口蓋裂学会雑誌 16 ( 4 ) 190 1991

人間ドッグ受診者の口腔内診査成績について(2)-下顎第一大臼歯の臨床的症状-(共著)

逓信医学 43 ( 10 ) 607 1991

歯科口腔領域の術後感染予防症例におけるオフロキサシンの臨床効果および口腔組織濃度(共著)

歯界展望 73 ( 3 ) 731 1989

Cleidocranial dysplasia accompanied with pseudohypoparathyroidism I: Case report.

MACHIDA Junji, SHICHIRI Yasuharu, UENO Masami, IIDA Seiji, SATOH Masumi

Journal of Oral Surgery Society of Japan 35 ( 3 ) 755 - 760 1989

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

As cleidocranial dysplasia is one of the systemic bone disorders characterised by anomalies of clavicle, cranium, maxilla and mandible, complications are rarely found in other than the bone system.<BR>We have examined a boy, 8 years and 3 months old when first seen, of this disease accompanied with pseudohypoparathyroidism I, who is perhaps the second reported case in Japan. He was diagnosed to be pseudohypoparathyroidism I based on the attacks of tetany, calcified bodies in the brain found by CT, low Ca and high P levels in the blood, and on the Ellsworth-Howard examination. He was diagnosed to have cleidocranial dysplasia because of the specific motion of approaching shoulders, late existence of the anterior fontanell, and teeth anomalies as written below.<BR>At the examination of 9 years and 4 months, D+D/D+D and cuspids of E/E/E/E erupted, but no permanent tooth had erupted, all remaining in the jaws ascertained by roentgenography. Several serious carious deciduous teeth were extracted at this time. At the examination of 12 years and 3 months, however, no permanent tooth was seen except for the incisor edges of the lower central incisors.<BR>Cephalometric x-ray analysis at 9 years and 4 months revealed maxillary maldevelopment to anterior and down directions, progenia, and maldevelopment of the mandibular angle. These were also found at the 12 years 3 months examination, but the amount of the maxillary and mandibular developments during these periods were nearly the same as that of normal boys.<BR>The etiology of cleidocrnial dysplasia was discussed based on the present case and on some literatures reporting the complications that accompanied this disease.

DOI： 10.5794/jjoms.35.755

Other Link： http://search.jamas.or.jp/link/ui/1990062085

人間ドッグ受診者の口腔内診査成績について(1)(共著)

逓信医学 41 ( 8 ) 471 1989

全上下顎同時移動手術における口腔外科的問題点について(共著)

大阪大学歯学雑誌 33 ( 2 ) 456 1988

Mechanical contraction properties of the tensor veli palatini muscle.

SAKAMOTO Katsuya, NISHIO Juntaro, KOGOU Mikihiko, HAMAMURA Yasushi, INOUE Kazuo, KURIMOTO Takuya, NAKATA Masayuki, IIDA Seiji, MATSUYA Tokuzou

Journal of Oral Surgery Society of Japan 34 ( 9 ) 1845 - 1851 1988

Language：Japanese Publisher：Japanese Society of Oral and Maxillofacial Surgeons

This study was intended to clarify the mechanical contraction properties of the tensor veli palatini muscle in dogs. Twenty adult dogs were used under an intraperitoneum anesthesia of the pentobarbital sodium. The tension of the tensor veli paltini muscle was recorded by electrical stimulation to the motor nerve.<BR>Results were as follows:<BR>1. The contraction time and half relaxation time of maximal isometric twitch of the muscle were calculated as 13.7±0.7 msec and 10.4±1.2 msec, respectively.<BR>2. A clear summation of muscle contractions was obtained with stimulation at 20 Hz and maximal tetanic tension was at 90 Hz. The tetanus twitch tension ratio wasfound to be 10.7±1.1.<BR>3. The maximum rate of tension rise was observed at 150 Hz and value was 2.5±0.5 times as long as the rate of a twitch contraction.<BR>4. The contraction rate of an isotonic twitch was 3.2±0.7% and the maximum contraction rate was obtained at 80 Hz which was 26.3±1.9%.

DOI： 10.5794/jjoms.34.1845

Other Link： http://search.jamas.or.jp/link/ui/1989131379

口腔外科小手術後の疼痛に対するロキソプロフェンナトリウム(ロキソニン)の使用成績(共著)

浦出雅裕

診療と新薬 24 ( 7 ) 1559 - 184 1987

歯科口腔外科領域感染症に対する経口合成抗菌剤オフロキサシンの臨床効果(共著)

歯界展望 70 ( 4 ) 927 1987

口腔外科領域における小手術後の疼痛に対するフェナゾックス(アンフェナックナトリウム)の使用成績(共著)

基礎と臨床 20 ( 17 ) 677 1986

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