Faculty Profiles - Inoue Taketo

写真a

Inoue Taketo

Organization

Scheduled update Associate Professor

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Degree

博士（保健学） ( 神戸大学 )
博士（医学） ( 兵庫医科大学 )

Professional Memberships

JAPANESE SOCIETY OF CLINICAL EMBRYOLOGIST

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JAPAN SOCIETY FOR OVA RESEARCH

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JAPAN SOCIETY OF FERTILIZATION AND IMPLANTATION

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JAPAN SOCIETY FOR REPRODUCTIVE MEDICINE

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生殖補助医療技術教育カリキュラム標準化懇談会

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日本生殖医療支援システム研究会

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JAPAN SOCIETY OF ANDROLOGY

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Committee Memberships

日本卵子学会編集委員

2023.6

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日本卵子学会代議員

2023.3

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Japanese Society of Clinical Embryologist 代議員

2022.7

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Papers

Activation of the pentose phosphate pathway by microcurrent stimulation mediates antioxidant effects in inflammation-stimulated macrophages Reviewed International coauthorship International journal

Mikiko Uemura, Noriaki Maeshige, Atomu Yamaguchi, Xiaoqi Ma, Yunfei Fu, Taketo Inoue, Mami Matsuda, Yuya Nishimura, Tomohisa Hasunuma, Ji Wang, Hiroyo Kondo, Hidemi Fujino

Frontiers in Physiology 16 1666999 - 1666999 2025.11

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<jats:sec>
<jats:title>Introduction</jats:title>
<jats:p>Excessive inflammatory responses in macrophages lead to increased oxidative stress, and the excessive production of reactive oxygen species (ROS) causes tissue damage, contributing to the development of chronic diseases and tissue deterioration. Therefore, controlling the inflammatory response and ROS production is crucial for human health. Electrical stimulation (ES) has been shown to have antioxidant and anti-inflammatory effects on macrophages. However, the key pathway underlying these effects remains unclear.</jats:p>
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<jats:title>Methods</jats:title>
<jats:p>In this study, ES was applied to Lipopolysaccharide (LPS)-stimulated macrophages, and the production of ROS and 8–hydroxy–2′–deoxyguanosine (8-OHdG), inflammatory cytokine expression, and intracellular metabolites were analyzed in a glucose-6-phosphate dehydrogenase (G6PD) knockdown experiment, the rate-limiting enzyme of the Pentose Phosphate Pathway(PPP).</jats:p>
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<jats:title>Results</jats:title>
<jats:p>ES significantly increased sedoheptulose 7-phosphate (S7P), an intermediate metabolite in PPP, and reduced ROS and 8-OHdG production and the expression of inflammatory cytokines in LPS-stimulated macrophages. Meanwhile, ES did not exert antioxidant effects in G6PD-knockdown macrophages.</jats:p>
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<jats:title>Discussion</jats:title>
<jats:p>These findings indicate that the antioxidant effects of ES are mediated by PPP in LPS-stimulated macrophages.</jats:p>
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DOI： 10.3389/fphys.2025.1666999

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High Dose of Antithrombin Suppresses Neutrophil Extracellular Trap Formation in Human Neutrophils In Vitro Following Lipopolysaccharide- and Platelet-Induced Stimulation. Reviewed International journal

Michiko Aoyama-Ishikawa, Hideki Higashi, Hiromoto Murakami, Taketo Inoue, Noritomo Fujisaki, Keisuke Kohama

Surgical infections 26 ( 10 ) 762 - 769 2025.9

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Objective: During sepsis, blood antithrombin (AT) concentrations decrease; administering AT to patients with sepsis-associated intravascular coagulation has been shown to improve their prognosis. Neutrophil extracellular traps (NETs) are closely related to immunothrombosis; however, the relation between AT and NETs remains nebulous. This study examined the effects of AT on NETs of human neutrophils in vitro. Methods: Blood samples were collected from healthy volunteers, and the isolated neutrophils were seeded onto collagen-coated cell culture plates. The cells were then stimulated by lipopolysaccharide (LPS) with platelets. Human serum albumin (hAlb) was used as a control for AT. AT (0.01-10 U/mL) or hAlb was added 30 minutes after LPS and platelet treatment. The timing of AT addition was determined by the results of a single cell NETs assay. NET formation was assessed using enzyme-linked immunosorbent assay and immunostaining. Peptidyl arginine deiminase 4 (PAD4) nuclear transfer was detected by Western blotting. Results: Lipopolysaccharide-induced deoxyribonucleic acid (DNA)-binding neutrophil elastase substantially. NET formation over time was 3%, 15%, 50%, and 70% of the total neutrophils at 30, 60, 100, and 120 minutes after LPS stimulation, respectively. NETs evaluation in addition to AT at 15, 30, or 60 minutes after LPS stimulation showed that AT inhibited NET formation only at 30 minutes. High AT concentrations (i.e., 2-10 U/mL) substantially decreased NET formation and decreased nuclear expression of PAD4. Conclusion: The high concentrations of AT decrease NETs in human neutrophils induced by LPS and platelets via PAD4 pathway.

DOI： 10.1177/10962964251376946

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Time-series clustering of the migration speed of nucleolus-precursor bodies in human zygotes and live birth following assisted reproductive technology Reviewed International journal

Taketo Inoue, Sayumi Taguchi, Mikiko Uemura, Yoshiki Yamashita

Journal of Assisted Reproduction and Genetics 42 ( 8 ) 2609 - 2619 2025.7

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Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

DOI： 10.1007/s10815-025-03578-3

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Other Link： https://link.springer.com/article/10.1007/s10815-025-03578-3/fulltext.html
A hyaluronic acid-containing reagent compatible with glass-bottom dishes and capable of sustained binding of human spermatozoa. Reviewed International journal

Taketo Inoue, Hiroshi Iwayama, Mikiko Uemura, Sayumi Taguchi, Yoshiki Yamashita

Andrology 13 ( 3 ) 555 - 563 2025.3

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OBJECTIVE: Commercial products currently available for sperm selection utilizing hyaluronic acid (HA) binding prior to intracytoplasmic sperm injection (ICSI) are widely used but have some disadvantages. To potentially circumvent these limitations, we compared ICSI using a self-made hyaluronic acid (smHA) reagent with ICSI using SpermSlow. METHODS: The binding of the reagents to spermatozoa on plastic- or glass-bottom dishes was quantitated using spermatozoa that were isolated by density-gradient centrifugation and swim-up procedures (N = 10/group). Additionally, we investigated the relationship between the HA reagent used prior to ICSI and clinical outcomes after assisted reproduction with HA-ICSI (N = 81). RESULTS: The smHA reagent exhibited extremely stable binding to human spermatozoa. The binding time of spermatozoa was significantly longer in the smHA reagent than in SpermSlow on both plastic and glass dishes (plastic: 60.0 ± 0.0 min vs. 2.7 ± 5.9 min, P < 0.001; glass: 60.0 ± 0.0 min vs. 2.5 ± 1.8 min, P < 0.001). There were no significant differences in the normal fertilization rate between HA-ICSI with the smHA reagent (128/160, 80.0%) and HA-ICSI with SpermSlow (171/231, 74.0%, P = 0.184). The frequency of the blastocyst development from the HA-ICSI-derived zygote was significantly higher with the smHA reagent (74/101, 73.3%) than with SpermSlow (76/131, 58.0%, P = 0.019). The rates of biochemical pregnancy, clinical pregnancy, fetal heart movement, live birth, and miscarriage were not significantly different between HA-ICSI with the smHA reagent and HA-ICSI with SpermSlow. CONCLUSIONS: The blastulation rate was higher for HA-ICSI with the smHA reagent as compared with SpermSlow. Clinical outcomes, excluding blastulation, after HA-ICSI were the same using smHA reagent and using SpermSlow. Spermatozoa binding to the smHA reagent was not attenuated over a 60-min time course. In conclusion, this reagent may shorten and simplify HA-ICSI procedures because smHA can be used with any dish material, making it easier to observe the spindle or assess intracytoplasmic morphology.

DOI： 10.1111/andr.13683

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The relationship between controlled ovarian stimulation protocol, meiotic spindle visibility, position of the meiotic spindle relative to the polar body in the human oocyte, and clinical outcomes following ICSI. Reviewed International journal

Taketo Inoue, Yuki Matsuo, Sayumi Taguchi, Yoshiko Tsujimoto, Mikiko Uemura, Yoshiki Yamashita

Reproductive medicine and biology 23 ( 1 ) e12601 2024.12

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PURPOSE: To investigate the effects of different controlled ovarian stimulation (COS) protocols, including the progestin-primed ovarian stimulation (PPOS), long, short, and the gonadotropin-releasing hormone antagonist protocols, on meiotic spindle visibility and position within the oocyte and clinical outcomes following ICSI. METHODS: Before ICSI, spindle position (θ) just below the polar body (PB) was defined as 0° and categorized as follows: θ = 0°, 0° < θ ≤ 30°, 30° < θ ≤ 60°, 60° < θ ≤ 90°, 90° < θ ≤ 180°, between the PB and the oolemma, and nonvisible. The clinical outcomes after ICSI were retrospectively analyzed. RESULTS: The normal fertilization rate was significantly higher in oocytes with visible spindles than in oocytes with nonvisible spindles after each COS protocol, but did not differ based on spindle positioning (0° ≤ θ ≤ 180°). The rates of pregnancy, live birth/ongoing pregnancy, and miscarriage did not differ based on spindle visibility or positioning. In multinominal logistic regression analysis, female age was associated with spindle position, and the odds of a spindle located at 30° < θ ≤ 60°, at 60° < θ ≤ 90°, or at 90° < θ ≤ 180° were increased relative to θ = 0° in older women (odds ratio; 1.020, 1.030, and 1.060, respectively; p < 0.05). CONCLUSION: Meiotic spindle positioning in the oocyte does not affect normal fertilization, blastulation, pregnancy, live birth/ongoing pregnancy, and miscarriage after ICSI, independent of the COS protocol used.

DOI： 10.1002/rmb2.12601

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Sex Differences of Neutrophil Extracellular Traps on Lipopolysaccharide-Stimulated Human Neutrophils. Reviewed International journal

Michiko Ishikawa, Hiromoto Murakami, Hideki Higashi, Taketo Inoue, Noritomo Fujisaki, Keisuke Kohama

Surgical infections 2024.7

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Objective: Sex differences exist in sepsis, but the commitment of neutrophils to these differences remains unclear. Neutrophil extracellular traps (NETs) function to remove pathogens, yet excessive NETs release can contribute to organ damage. This study explores effects of the gender hormones on endotoxin-induced NETs using neutrophils from both male and female sources. Methods: Blood samples were collected from healthy volunteers. Isolated neutrophils were seeded in collagen-coated cell culture plates, and NETs were induced by lipopolysaccharide (LPS) treatment. After 15 minutes of LPS treatment, 17β-estradiol (0.03-272.4 ng/mL), testosterone enanthate (0.01-10 ng/mL), dimethyl sulfoxide, or ethanol (vehicle control) was added to the plates. These were incubated for three hours at 37°C with 5% CO2. Neutrophil extracellular traps formation was assessed using immunofluorescence staining. Results: Lipopolysaccharide-induced NETs formation was significantly greater in females than in males. In male-derived neutrophils, 17β-estradiol at above the blood concentrations significantly suppressed LPS-induced NETs. No effect was seen while using testosterone enanthate to NETs at any concentration. In female-derived neutrophils, 17β-estradiol, which was near to the highest concentration of non-pregnant women's blood, tended to increase NETs. Testosterone enanthate, which was near to female blood concentration, significantly promoted NETs. Conclusions: Sex differences existed in LPS-induced NETs of human neutrophil. In males, high concentrations of 17β-estradiol administration may have a suppressive effect on excessive NETs during infection. In females, endogenous gender hormones may promote NETs during infection. Sex differences in neutrophils may need to be considered in organ damage owing to NETs excess such as sepsis.

DOI： 10.1089/sur.2024.016

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EQUOL, A SOYBEAN METABOLITE WITH ESTROGEN-LIKE FUNCTIONS, DECREASES LIPOPOLYSACCHARIDE-INDUCED HUMAN NEUTROPHIL EXTRACELLULAR TRAPS IN VITRO. Reviewed International journal

Hiromoto Murakami, Michiko Ishikawa, Hideki Higashi, Keisuke Kohama, Taketo Inoue, Noritomo Fujisaki, Jun-Ichi Hirata

Shock (Augusta, Ga.) 61 ( 5 ) 695 - 704 2024.5

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OBJECTIVE: Neutrophil extracellular traps (NETs) defend against acute infections. However, their overexpression causes organ failure during sepsis. Control of NET formation may improve the outcomes of patients with sepsis. Equol, a soybean isoflavone, is a female hormone analog, which prevents inflammation. We evaluated the effects of equol on NET formation in human neutrophils during inflammatory stimulation in vitro. METHODS: Healthy volunteers provided blood samples. An enzyme-linked immunosorbent assay (ELISA) assessed serum equol concentrations. NET formation in neutrophils was induced by lipopolysaccharide (LPS) treatment. ELISA quantified DNA-binding elastase, and immunostaining assessed NET formation. Reverse-transcription quantitative PCR and western blotting detected G-protein-coupled receptor 30 (GPR30) or peptidyl arginine deiminase 4 (PAD4) expression. Flow cytometry assessed neutrophil phagocytic ability with inactivated Escherichia coli. RESULTS: In neutrophils derived from males with low-serum equol levels (low-serum equol group), equol significantly decreased DNA-binding elastase levels and NET formation. Equol did not decrease NETs in neutrophils from males with high-serum equol levels. GPR30 expression of neutrophils was higher in the low-serum than in the high-serum equol group. PAD4 mRNA levels and nuclear PAD4 protein expression also decreased than the vehicle control in the low-serum equol group. Equol did not alter the phagocytic ability of neutrophils. In neutrophils from young females, equol had no inhibitory effect on NET formation. CONCLUSIONS: Equol decreases LPS-induced NET formation in neutrophils from males via inhibition of PAD4 expression. Our findings provide a rationale for investigating a new therapeutic approach using equol to control neutrophil activity during sepsis.

DOI： 10.1097/SHK.0000000000002273

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Electrical stimulation facilitates NADPH production in pentose phosphate pathway and exerts an anti-inflammatory effect in macrophages. Reviewed International coauthorship International journal

Mikiko Uemura, Noriaki Maeshige, Atomu Yamaguchi, Xiaoqi Ma, Mami Matsuda, Yuya Nishimura, Tomohisa Hasunuma, Taketo Inoue, Jiawei Yan, Ji Wang, Hiroyo Kondo, Hidemi Fujino

Scientific reports 13 ( 1 ) 17819 - 17819 2023.10

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Macrophages play an important role as effector cells in innate immune system. Meanwhile, macrophages activated in a pro-inflammatory direction alter intracellular metabolism and damage intact tissues by increasing reactive oxygen species (ROS). Electrical stimulation (ES), a predominant physical agent to control metabolism in cells and tissues, has been reported to exert anti-inflammatory effect on immune cells. However, the mechanism underlying the anti-inflammatory effects by ES is unknown. This study aimed to investigate the effect of ES on metabolism in glycolytic-tricarboxylic acid cycle (TCA) cycle and inflammatory responses in macrophages. ES was performed on bone marrow-derived macrophages and followed by a stimulation with LPS. The inflammatory cytokine expression levels were analyzed by real-time polymerase chain reaction and ELISA. ROS production was analyzed by CellRox Green Reagent and metabolites by capillary electrophoresis-mass spectrometry. As a result, ES significantly reduced proinflammatory cytokine expression levels and ROS generation compared to the LPS group and increased glucose-1-phosphate, a metabolite of glycogen. ES also increased intermediate metabolites of the pentose phosphate pathway (PPP); ribulose-5-phosphate, rebose-5 phosphate, and nicotinamide adenine dinucleotide phosphate, a key factor of cellular antioxidation systems, as well as α-Ketoglutarate, an anti-oxidative metabolite in the TCA cycle. Our findings imply that ES enhanced NADPH production with enhancement of PPP, and also decreased oxidative stress and inflammatory responses in macrophages.

DOI： 10.1038/s41598-023-44886-x

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The role of death receptor signaling pathways in mouse Sertoli cell avoidance of apoptosis during LPS- and IL-18-induced inflammatory conditions. Reviewed International journal

Taketo Inoue, Michiko Aoyama-Ishikawa, Mikiko Uemura, Keisuke Kohama, Noritomo Fujisaki, Hiromoto Murakami, Taihei Yamada, Junichi Hirata

Journal of reproductive immunology 158 103970 - 103970 2023.8

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Lipopolysaccharide (LPS) triggers infectious acute inflammation, and interleukin (IL)-18 is an inflammasome-mediated cytokine. We previously demonstrated that endogenous IL-18 induces testicular germ cell apoptosis during acute inflammation when plasma IL-18 levels are high. Additionally, high-dose recombinant IL-18 (rIL-18) induced Leydig cell apoptosis. The blood-testis barrier formed by Sertoli cells protects testicular germ cells from both exogenous and endogenous harmful substances. However, the impact of LPS and IL-18 on Sertoli cells remained unclear. We stimulated TM4 cells, a mouse Sertoli cell line, with LPS (200 or 1000 ng/mL) or rIL-18 (0.1-100 ng/mL) at levels that induced Leydig cell apoptosis in our previous study and assessed caspase 3 cleavage and the mRNA expression of inflammatory cytokines and markers of apoptotic pathways (Tnfr1, Fasl, Fas, Fadd) after stimulation. Il6 mRNA was increased by LPS stimulation. Tnfα mRNA was increased by 200 ng/mL LPS but not 1000 ng/mL LPS. Fas was increased, but Fasl was decreased, by LPS. LPS had little influence on Tnfr1 or Fadd mRNA expression and did not induce apoptosis. Il18 mRNA was not increased, and Il18r1 was significantly decreased following LPS treatment. Treatment with rIL-18 increased Il18r1 mRNA and induced inflammation, but decreased Tnfr1 and had little influence on apoptosis, as indicated by Tnfα, Fasl, Fas, Fadd and cleaved caspase 3. These results suggested that Sertoli cells do not easily undergo apoptosis despite strong inflammatory stimuli. Additionally, Sertoli cells may resist inflammation and play a larger role in protecting testicular homeostasis than other component cells of the testis.

DOI： 10.1016/j.jri.2023.103970

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The migration speed of nucleolar precursor bodies in pronuclei affects in vitro fertilization‐derived human embryo ploidy status and live birth Reviewed International journal

Taketo Inoue, Sayumi Taguchi, Mikiko Uemura, Yoshiko Tsujimoto, Kana Kokunai, Kayoe Ikawa, Yoshiki Yamashita

Reproductive Medicine and Biology 2023.1

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DOI： 10.1002/rmb2.12497

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Outcome of in vitro fertilization cycles with automatic time-lapse instrumentation combined with the early embryo viability assessment score. Reviewed International journal

Kana Kokunai, Yoshiki Yamashita, Taketo Inoue, Sayumi Taguchi, Yoshiko Tsujimoto, Kayoko Hirao, Syuji Yamamoto, Natsuho Nakamura, Yoshito Terai, Masahide Ohmichi

The journal of obstetrics and gynaecology research 47 ( 7 ) 2387 - 2393 2021.7

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DOI： 10.1111/jog.14747

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Migration speed of nucleolus precursor bodies in human male pronuclei: a novel parameter for predicting live birth. Reviewed International journal

Taketo Inoue, Sayumi Taguchi, Mikiko Uemura, Yoshiko Tsujimoto, Kazunori Miyazaki, Yoshiki Yamashita

Journal of assisted reproduction and genetics 38 ( 7 ) 1725 - 1736 2021.7

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DOI： 10.1007/s10815-021-02172-7

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Monophasic Pulsed Current Stimulation of Duty Cycle 10% Promotes Differentiation of Human Dermal Fibroblasts into Myofibroblasts Reviewed

Mikiko UEMURA, Masaharu SUGIMOTO, Yoshiyuki YOSHIKAWA, Terutaka HIRAMATSU, Taketo INOUE

Physical Therapy Research 24 ( 2 ) 145 - 152 2021

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OBJECTIVE: Many clinical trials have shown the therapeutic effects of electrical stimulation (ES) in various conditions. Our previous studies showed that ES (200 μA and 2 Hz) promotes migration and proliferation of human dermal fibroblasts (HDFs). However, the effective duty cycle and the effect of ES on myofibroblast differentiation are unclear. This study aimed to investigate the relationship between duty cycle and myofibroblast differentiation. METHODS: HDFs were subjected to ES (200 μA and 2 Hz) for 24 h with the duty cycle adapted at 0% (control), 10%, 50%, or 90%. α-smooth muscle actin (SMA) and transforming growth factor (TGF)-β1 mRNA and α-SMA protein expressions were assessed. Collagen gel contraction was observed for 48 h after ES initiation and the gel area was measured. Cell viability and pH of culture medium were analyzed for cytotoxicity of the ES. RESULTS: Cell viabilities were decreased in the 50% and the 90% groups but ES did not influence on pH of culture media. ES with a duty cycle of 10% significantly promoted the mRNA expression of α-SMA and TGF-β1. α-SMA protein expression in the 10% group was also significantly higher than that of the control group. Collagen gel subjected to ES with a duty cycle of 10% was contracted. CONCLUSION: Duty cycle can influence on myofibroblast differentiation and ES with a duty cycle 10% is the effective for wound healing.

DOI： 10.1298/ptr.e10064

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Interleukin-18 levels and mouse Leydig cell apoptosis during lipopolysaccharide-induced acute inflammatory conditions Reviewed

Taketo Inoue, Michiko Aoyama-Ishikawa, Mikiko Uemura, Hayato Yamashita, Yuka Koga, Mariko Terashima, Makoto Usami, Joji Kotani, Junichi Hirata

Journal of Reproductive Immunology 141 103167 2020.9

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DOI： 10.1016/j.jri.2020.103167

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Failure of complete hatching of ICSI-derived human blastocyst by cell herniation via small slit and insufficient expansion despite ongoing cell proliferation Reviewed International journal

Taketo Inoue, Mikiko Uemura, Kazunori Miyazaki, Yoshiki Yamashita

Journal of Assisted Reproduction and Genetics 36 ( 8 ) 1579 - 1589 2019.8

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DOI： 10.1007/s10815-019-01521-x

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Other Link： http://link.springer.com/article/10.1007/s10815-019-01521-x/fulltext.html
The Evaluation of Sperm’s Hyaluronic Acid Binding Ability as a Predictive Value for the Clinical Success of Intracytoplasmic Sperm Injection Reviewed

IGAWA Kayoe, IGAWA Kayoe, YAMASHITA Yoshiki, INOUE Taketo, TAGUCHI Sayumi, TUJIMOTO Yoshiko, HIRAO Kayoko, YAMAMOTO Syuji, NAKAMURA Natsuho, NAKAMURA Natsuho, MIYAZAKI Kazunori, TERAI Yoshito, TERAI Yoshito, OHMICHI Masahide, OHMICHI Masahide

Bulletin of the Osaka Medical College 65 ( 1-2 ) 2019

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Association of follicular fluid volume with membrane stretchability of human metaphase II oocytes following the gonadotropin-releasing hormone agonist protocol during intracytoplasmic sperm injection Reviewed

Taketo Inoue, Sayumi Taguchi, Kayoko Hirao, Yoshiko Tsujimoto, Shuji Yamamoto, Mikiko Uemura, Kazunori Miyazaki, Yoshiki Yamashita

Reproductive Medicine and Biology 17 ( 3 ) 283 - 288 2018.7

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DOI： 10.1002/rmb2.12102

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BIA(bioelectrical impedance analysis)法で定量した日本人糖尿病患者の体組成と栄養評価法の検討 Reviewed

松尾真里, 宇佐美眞, 三好真琴, 上野真波, 梶田歩, 山下勇人, 植村弥希子, 井上岳人, 内田絢子, 芝唯, 三ヶ尻礼子, 山本育子, 戸田明代, 高橋路子, 木戸良明, 坂本憲広

栄養 3 ( 1 ) 45 - 50 2018.3

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Taking a sitting position within 13 days of subarachnoid hemorrhage onset prevents decline in the ability to perform activities of daily living and shortens hospitalization duration Reviewed

Mikiko Uemura, Taketo Inoue, Shingo Kuwata, Yoshiyuki Yoshikawa, Hiroaki Matsumoto, Yutaka Hirata

International Journal on Disability and Human Development 17 ( 4 ) 517 - 524 2018

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精巣男性ホルモン産生細胞におけるアポトーシスへのエンドトキシン及びIL-18の関与

井上岳人, 石川倫子, 植村弥希子, 山下勇人, 古賀由華, 宇佐美眞, 小谷穣治

エンドトキシン・自然免疫研究 20 31 - 34 2017.10

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Other Link： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J05942&link_issn=&doc_id=20180319400008&doc_link_id=%2Ffb1endto%2F2017%2F002000%2F008%2F0031-0034%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Ffb1endto%2F2017%2F002000%2F008%2F0031-0034%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
マウスエンドトキシン血症下肝臓でのNeutrophil Extracellular Traps(NETs)形成へのInterleukin‐18(IL‐18)の関与

石川倫子, 神前雅彦, 神前雅彦, 井上岳人, 小濱圭祐, 藤崎宣友, 上田敬博, 小谷穣治

エンドトキシン血症救命治療研究会誌 21 ( 1 ) 215 - 219 2017.10

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The frequency of monophasic pulsed current introduced migration and activation of FAK in human dermal fibroblasts

植村弥希子, 植村弥希子, 杉元雅晴, 井上岳人, 前重伯壮, 古賀由華, 吉川義之, 宇佐美眞

物理療法科学 24 26 - 31 2017.9

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A lard-rich high-fat diet increases hepatic peroxisome proliferator–activated receptors in endotoxemic rats Reviewed

Motoki Kai, Makoto Miyoshi, Mayu Fujiwara, Yuya Nishiyama, Taketo Inoue, Noriaki Maeshige, Yasuhiro Hamada, Makoto Usami

Journal of Surgical Research 212 22 - 32 2017.5

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DOI： 10.1016/j.jss.2016.11.048

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INTERLEUKIN-18 REDUCES BLOOD GLUCOSE and MODULATES PLASMA CORTICOSTERONE in A SEPTIC MOUSE MODEL Reviewed International journal

Hayato Yamashita, Michiko Ishikawa, Taketo Inoue, Makoto Usami, Yu Usami, Joji Kotani

Shock 47 ( 4 ) 455 - 462 2017.4

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DOI： 10.1097/SHK.0000000000000747

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The association of follicular fluid volume with human oolemma stretchability during intracytoplasmic sperm injection Reviewed International journal

Taketo Inoue, Yoshiki Yamashita, Yoshiko Tsujimoto, Shuji Yamamoto, Sayumi Taguchi, Kayoko Hirao, Mikiko Uemura, Kayoe Ikawa, Kazunori Miyazaki

Clinical and Experimental Reproductive Medicine 44 ( 3 ) 126 - 126 2017

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DOI： 10.5653/cerm.2017.44.3.126

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「外科侵襲・術後管理と新しい免疫の概念」外科侵襲とInterleukin-18遺伝子多型

石川倫子, 山田太平, 滿保直美, 藤崎宣友, 上田敬博, 井上岳人, 小谷穣治

外科と代謝・栄養 51 ( 1 ) 17 - 24 2017

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Percentage of motile spermatozoa at 22 hours after swim-up procedure: An indicator for intracytoplasmic sperm injection? Reviewed International journal

Taketo Inoue, Yukiko Yonezawa, Hironobu Sugimoto, Mikiko Uemura, Yuri Ono, Junji Kishi, Nobuyuki Emi, Yoshiyuki Ono

Clinical and Experimental Reproductive Medicine 43 ( 3 ) 157 - 163 2016

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DOI： 10.5653/cerm.2016.43.3.157

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Endogenous interleukin 18 regulates testicular germ cell apoptosis during endotoxemia Reviewed International journal

Taketo Inoue, Michiko Aoyama-Ishikawa, Shingo Kamoshida, Satoshi Nishino, Maki Sasano, Nobuki Oka, Hayato Yamashita, Motoki Kai, Atsunori Nakao, Joji Kotani, Makoto Usami

REPRODUCTION 150 ( 2 ) 105 - 114 2015.8

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DOI： 10.1530/rep-14-0427

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Endogenous Interleukin 18 Suppresses Hyperglycemia and Hyperinsulinemia during the Acute Phase of Endotoxemia in Mice Reviewed International journal

Hayato Yamashita, Michiko Aoyama-Ishikawa, Miki Takahara, Chisato Yamauchi, Taketo Inoue, Makoto Miyoshi, Noriaki Maeshige, Makoto Usami, Atsunori Nakao, Joji Kotani

Surgical Infections 16 ( 1 ) 90 - 96 2015

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DOI： 10.1089/sur.2013.269

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エンドトキシン血症時における精巣生殖細胞アポトーシスと内因性IL‐18の役割

井上岳人, 石川倫子, 西野哲, 笹野真希, 岡伸樹, 山下勇人, 鴨志田伸吾, 中尾篤典, 宇佐美眞, 小谷穣治

エンドトキシン・自然免疫研究 17 98 - 102 2014.11

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Successful Pregnancy Following Transfer of Frozen—Thawed Day 7 Blastocysts Derived from Transported Oocytes Reviewed

Taketo Inoue, Yoshiyuki Ono, Yukiko Yonezawa, Takuo Fujiwara, Ataru Nohara, Osamu Mimura, Junji Kishi, Nobuyuki Emi

Journal of Mammalian Ova Research 31 ( 1 ) 52 - 56 2014.4

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DOI： 10.1274/jmor.31.52

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Testicular germ cell apoptosis during orchitis Reviewed

Taketo Inoue

Spermatozoa: Biology, Motility and Function and Chromosomal Abnormalities 149 - 168 2014.1

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Improvement of live birth rate following frozen–thawed blastocyst transfer by combination of prednisolone administration and stimulation of endometrium embryo transfer Reviewed

Taketo Inoue, Yoshiyuki Ono, Yukiko Yonezawa, Junji Kishi, Nobuyuki Emi

Open Journal of Obstetrics and Gynecology 04 ( 13 ) 745 - 750 2014

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DOI： 10.4236/ojog.2014.413103

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Oocyte quality improvement using a herbal medicine comprising 7 crude drugs Reviewed

Taketo Inoue, Yoshiyuki Ono, Yukiko Yonezawa, Michinobu Oi, Naomi Kobayashi, Junji Kishi, Nobuyuki Emi

Open Journal of Obstetrics and Gynecology 03 ( 01 ) 195 - 202 2013

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DOI： 10.4236/ojog.2013.31a036

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Preservation of spermatozoa by refrigeration Reviewed

Taketo Inoue, Yoshiyuki Ono, Nobuyuki Emi

Pregnancy: Risk Factors, Management and Recovery 121 - 146 2012.2

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敗血症におけるアンチトロンビンIII(Antithrombin III:AT III)の効果

岡伸樹, 青山倫子, 青山倫子, 上田敬博, 井上岳人, 前重伯壮, 宇佐美眞, 小谷穣治

エンドトキシン・自然免疫研究 15 35 - 39 2012

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エンドトキシン血症下の骨髄細胞動向とアポトーシスにおけるTLR4 signalの役割とその雌雄差

高原美樹, 山内千里, 青山倫子, 前重伯壮, 三好真琴, 井上岳人, 神前雅彦, 藤原麻有, 上田敬博, 寺嶋真理子, 宇佐美眞, 小谷穣治

エンドトキシン血症救命治療研究会誌 15 ( 1 ) 110 - 113 2011.10

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エンドトキシン血症時の性差によるIL-18の役割と腸管iNOS発現の差異

青山倫子, 青山倫子, 神前雅彦, 井上岳人, 前重伯壮, 三好真琴, 上田敬博, 宇佐美眞, 小谷穣治

エンドトキシン・自然免疫研究 14 1 - 5 2011

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Successful pregnancy after intracytoplasmic sperm injection with testicular spermatozoa transported only under refrigeration Reviewed

Taketo Inoue, Hironobu Sugimoto, Kazutoshi Okubo, Nobuyuki Emi, Yukiko Matsushita, Kenji Kojima, Mitsuaki Nakamura, Yoshiyuki Ono

Reproductive Medicine and Biology 9 ( 3 ) 173 - 177 2010.9

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DOI： 10.1007/s12522-010-0053-6

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10%ポドフィリン安息香チンキを用いた外陰部尖圭コンジローマの治療 Reviewed

井上岳人, 小野吉行, 江見信之, 中村光彰

産科と婦人科 76 ( 4 ) 485 - 488 2009.4

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Scrape-Assisted Hatching Using Piezo Micromanipulator Reviewed

井上岳人, 松下由紀子, 江見信之, 小島謙二, 小野吉行

Journal of Mammalian Ova Research 26 ( 2 ) 94 - 96 2009

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DOI： 10.1274/jmor.26.94

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Books

日本一やさしい胚培養士実践テキスト

井上岳人, 田口朝優姫（ Role： Contributor , 受精卵の評価）

中外医学社 2025.8 （ ISBN:9784498176003 ）

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脳卒中片麻痺患者の長下肢装具手協開始日と歩行獲得の関連性の検証

植村弥希子, 田中翔太, 吉川義之, 井上岳人, 前重伯壮, 北村瑠玲, 藤原正盛

第14回日本支援工学理学療法学会学術大会抄録 2025.12

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EZRを用いた実践的統計解析

井上岳人

第31回日本臨床エンブリオロジスト学会ワークショップ実技書・抄録集 2025.12

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臨床研究の信頼性を高める統計解析の実践

井上岳人

第43 回日本受精着床学会総会・学術講演会プログラム・講演抄録集 103 - 103 2025.8

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核小体前駆体の移動速度の時系列解析とART由来ヒト前核期受精卵の生児獲得率

井上岳人, 田口朝優姫, 辻本賀子, 植村弥希子, 松尾祐希, 後藤優佳子, 辻千紘, 山下能毅

Journal of Mammalian Ova Research 42 ( 1 ) S31 - S31 2025.4

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A female-hormone-like soybean metabolite decreases human neutrophil extracellular traps during lipopolysaccharide treatment

Hiromoto Murakami, Michiko Ishikawa, Hideki Higashi, Keisuke Kohama, Noritomo Fujisaki, Taketo Inoue, Junichi Hirata

2025.3

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核小体前駆体の移動速度の時系列解析とIVF/ICSI由来ヒト前核期受精卵の生児獲得率

井上岳人, 田口朝優姫, 辻本賀子, 植村弥希子, 松尾祐希, 後藤優佳子, 辻千紘, 山下能毅

日本臨床エンブリオロジスト学会雑誌 26 113 - 113 2024.12

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生殖医療の統計学入門 EZR編

井上岳人

日本臨床エンブリオロジスト学会雑誌 26 69 - 70 2024.12

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性ホルモンがneutrophil extracellular traps(NETs)に与える影響の検討

村上博基, 石川倫子, 東英樹, 小濱圭祐, 井上岳人, 白井邦博, 藤崎宣友, 平田淳一

日本集中治療医学会学術集会(Web) 51st 2024

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卵巣刺激法別にみた紡錘体と極体との相対的位置関係とICSI後の生児獲得および流産について

松尾祐希, 井上岳人, 辻本賀子, 平尾佳代子, 山本修士, 田口朝優姫, 後藤優佳子, 山下能毅

日本臨床エンブリオロジスト学会雑誌 25 231 - 231 2023.12

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アンチトロンビンはヒト好中球の neutrophil extracellular traps(NETs) を抑制する

石川倫子, 村上博基, 東英樹, 井上岳人, 小濱圭祐

第51回日本救急医学会総会・学術集会 2023.11

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Migration Speed of Nucleolar Precursor Bodies in Pronuclei Affecting In Vitro Fertilization-derived Human Embryo Ploidy Status, Pregnancy, Live Birth, and Miscarriage

Taketo Inoue, Sayumi Taguchi, Mikiko Uemura, Yoshiko Tsujimoto, Kayoko Hirao, Shuji Yamamoto, Yuki Matsuo, Yukako Goto, Yoshiki Yamashita

21st World Congress on In Vitro Fertilization (ISIVF2023) 69 - 69 2023.11

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Development of a Physiological Intracytoplasmic Sperm Injection Reagent Compatible with Glass-bottom Dishes and Capable of Sustained Binding of Human Spermatozoa

Taketo Inoue, Hiroshi Iwayama, Mikiko Uemura, Sayumi Taguchi, Yoshiko Tsujimoto, Kayoko Hirao, Shuji Yamamoto, Yuki Matsuo, Yukako Goto, Yoshiki Yamashita

21st World Congress on In Vitro Fertilization (ISIVF2023) 70 - 70 2023.11

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The Role of Death Receptor Signaling Pathways in TM4 Sertoli Cell Avoidance of Apoptosis During Lipopolysaccharide- and Interleukin-18-induced Inflammatory Conditions

Taketo Inoue, Michiko Aoyama-Ishikawa, Mikiko Uemura, Keisuke Kohama, Noritomo Fujisaki, Hiromoto Murakami, Taihei Yamada, Junichi Hirata

21st World Congress on In Vitro Fertilization (ISIVF2023) 105 - 105 2023.11

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卵巣刺激法別にみた紡錘体と極体との相対的位置関係とICSI 後のヒト胚発生および生児獲得について

松尾祐希, 井上岳人, 辻本賀子, 平尾佳代子, 山本修士, 田口朝優姫, 後藤優佳子, 山下能毅

日本生殖医学会雑誌 68 ( 4 ) 289 - 289 2023.10

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17βエストラジオールはエンドトキシンによるヒト好中球のneutrophil extracellular traps (NETs)形成を抑制するか．

石川倫子, 村上博基, 小濱圭祐, 東英樹, 井上岳人, 藤崎宣友, 山田太平, 白井邦博, 平田淳一

第37回日本Shock学会学術集会プログラム・抄録集 37 ( 1 ) 85 - 85 2023.7

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Neutrophil extracellular traps (NETs) 抑制作用への大豆イソフラボン代謝産物エクオールの可能性について．

村上博基, 石川倫子, 東英樹, 小濱圭祐, 井上岳人, 山田太平, 白井邦博, 藤崎宣友, 平田淳一

第37回日本Shock学会学術集会プログラム・抄録集 37 ( 1 ) 92 - 92 2023.7

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ヒト肺毛細血管内皮細胞傷害に対する水素含有培地の有効性の検討

山田太平, 渡邉暁洋, 瀬谷海月, 中弘智華, 石川倫子, 東英樹, 小濱圭祐, 滿保直美, 井上岳人

日本外傷学会雑誌 37 ( 2 ) 221 - 221 2023.6

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A female-hormone-like soybean metabolite decreases human neutrophil extracellular traps during lipopolysaccharide treatment

2023.6

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精子との結合力が減衰しないガラスボトムシャーレ対応のPICSI用試薬の開発

井上岳人, 岩山広, 田口朝優姫, 植村弥希子, 辻本賀子, 平尾佳代子, 山本修士, 松尾祐希, 山下能毅

Journal of Mammalian Ova Research 40 ( 1 ) S53 - S53 2023.4

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IVF由来受精卵において雄性前核内核小体前駆体の移動速度は生児獲得を予測する非侵襲的指標となる

井上岳人, 田口朝優姫, 植村弥希子, 辻本賀子, 平尾佳代子, 山本修士, 松尾祐希, 山下能毅

Journal of Mammalian Ova Research 40 ( 1 ) S38 - S38 2023.4

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ARTにおけるマニピュレーション技術を考える～ゴッドハンドを目指して～ヒアルロン酸を用いた生理学的精子選択術を再考する

井上岳人

Journal of Mammalian Ova Research 40 ( 1 ) S20 - S20 2023.4

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女性ホルモンおよびエクオールのneutrophil extracellular traps (NETs) 抑制作用について

村上博基, 石川倫子, 東英樹, 小濱圭祐, 井上岳人, 山田太平, 白井邦博, 藤崎宣友, 平田淳一

第50回日本集中治療医学会学術集会演題抄録 30 ( Suppl.1 ) 216 - 216 2023.3

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電気刺激はマクロファージの HIF-1αを抑制し細胞内代謝を変化させることで抗炎症・抗酸化作用を発揮する

植村弥希子, 前重伯壮, 山口亜斗夢, Ma Xiaoqi, 井上岳人, 近藤浩代, 藤野英己

日本物理療法合同学術大会 2023 抄録集 2023 O - 2 2023.2

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直流微弱電流はマクロファージ内のペントースリン酸経路の賦活を介して抗酸化・抗炎症作用を発揮する

植村弥希子, 前重伯壮, 山口亜斗夢, Ma Xiaoqi, 井上岳人, 寺師浩人, 近藤浩代, 藤野英己

第52 回日本創傷治癒学会 52回 57 - 57 2022.11

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女性ホルモン類似物質の好中球細胞外トラップ(NETs)に対する効果

村上博基, 石川倫子, 高橋知佳子, 砂川卓哉, 清水美沙, 西村壮太, 新海貴士, 野間光貴, 小濱圭祐, 平田淳一, 井上岳人

日本救急医学会雑誌 33 ( 10 (Web) ) 2022.10

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IVF由来受精卵において前核内核小体前駆体の移動速度は生児獲得を予測する非侵襲的指標となる

井上岳人, 田口朝優姫, 植村弥希子, 辻本賀子, 平尾佳代子, 山本修士, 山下能毅

第40回日本受精着床学会総会・学術講演会．プログラム・講演抄録集 113 - 113 2022.7

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The migration speed of nucleolar precursor bodies in pronuclei affects in vitro fertilization-derived human embryo ploidy status

Taketo Inoue, Sayumi Taguchi, Mikiko Uemura, Yoshiko Tsujimoto, Kana Kokunai, Kayoe Ikawa, Yoshiki Yamashita

Human Reproduction 37 ( Supplement 1 ) i277 - i278 2022.7

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DOI： 10.1002/rmb2.12497

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雄性前核内の核小体前駆体移動速度はヒト胚発生能を予測する非侵襲的指標となる

井上岳人, 田口朝優姫, 植村弥希子, 辻本賀子, 平尾佳代子, 山本修士, 宮崎和典, 山下能毅

日本臨床エンブリオロジスト学会雑誌 23 ( 2 ) 186 - 186 2021.12

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IL-18 levels and TM3 mouse Leydig cell apoptosis during LPS-induced acute inflammatory conditions.

Taketo Inoue, Michiko Ishikawa, Mikiko Uemura, Makoto Usami, Joji Kotani, Junichi Hirata

126 - 126 2021.10

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前核内動態に着目した胚発生の指標

井上岳人

日本生殖医学会雑誌 66 ( 4 ) 125 - 125 2021.10

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Endogenous IL-18 improved female survival in septic model mice

Michiko Ishikawa, Taketo Inoue, Keisuke Kohama, Joji Kotani, Junichi Hirata

16th Meeting of the International Endotoxin and Innate Immunity Society 92 - 92 2021.10

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ゼロから作るラボワークフロー

井上岳人

第13回生殖補助医療胚培養士セミナー要旨集 10 - 12 2021.9

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子宮内膜症合併不妊における ART の有用性の検討

山下能毅, 井上岳人, 田口朝優姫, 平尾佳代子, 山本修二, 辻本賀子, 井川佳世恵, 中村奈津穂, 穀内香奈, 劉昌恵, 大道正英

第39回日本受精着床学会総会・学術講演会．プログラム・講演抄録集 84 - 84 2021.7

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子宮内膜症合併不妊におけるARTの有用性の検討

山下能毅, 井上岳人, 田口朝優姫, 平尾佳代子, 辻本賀子, 山本修士, 宮崎和典, 穀内香奈, 中村奈津穂, 劉昌恵, 井川佳世恵, 大道正英

日本エンドメトリオーシス学会プログラム・抄録集 42nd 2021

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PGT-AにおけるEEVA Score(Early Embryo Viability Assessment Score)の有用性の検討

山下能毅, 井上岳人, 田口朝優姫, 穀内香奈, 中村奈津穂, 井川佳世恵, 劉昌恵, 大道正英

産婦人科の進歩 73 ( 4 ) 2021

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ヒト前核内の核小体前駆体移動速度は生児獲得/継続妊娠の指標となる

井上岳人, 田口朝優姫, 植村弥希子, 辻本賀子, 平尾佳代子, 山本修士, 宮崎和典, 山下能毅

日本生殖医学会雑誌 65 ( 4 ) 172 - 172 2020.11

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前核内の核小前駆体の移動速度はヒト胚発生の指標となる．

井上岳人, 田口朝優姫, 植村弥希子, 平尾佳代子, 辻本賀子, 山本修士, 宮崎和典, 山下能毅

第38回日本受精着床学会総会・学術講演会．プログラム・講演抄録集 74 - 74 2020.10

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Migration speed of nucleolar precursor bodies in human male pronuclei: A novel parameter for predicting live birth/ongoing pregnancy

INOUE Taketo, TAGUCHI Sayumi, UEMURA Mikiko, TSUJIMOTO Yoshiko, HIRAO Kayoko, MIYAZAKI Kazunori, YAMASHITA Yoshiki

The Journal of Reproduction and Development Supplement 66 ( Suppl. ) j106 - j106 2020.9

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DOI： 10.14882/jrds.113.0_P-124

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MIGRATION SPEED OF NUCLEOLAR PRECURSOR BODIES IN PRONUCLEI: A NOVEL PARAMETER FOR PREDICTING LIVE BIRTH.

Taketo Inoue, Sayumi Taguchi, Mikiko Uemura, Yoshiko Tsujimoto, Kazunori Miyazaki, Yoshiki Yamashita

FERTILITY AND STERILITY 114 ( 3 ) E118 - E119 2020.9

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DOI： 10.1016/j.fertnstert.2020.08.354

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The migration speed of nucleolar precursor bodies in pronuclei is a predictor of human embryo development

Taketo Inoue, Sayumi Taguchi, Mikiko Uemura, Kazunori Miyazaki, Yoshiki Yamashita

HUMAN REPRODUCTION 35 50 - 51 2020.7

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ICSIの際に透明帯に形成される穿刺孔は孵化不成立のリスク因子となる

井上岳人, 田口朝優姫, 植村弥希子, 平尾佳代子, 辻本賀子, 宮崎和典, 山下能毅

第37回日本受精着床学会総会・学術講演会．プログラム・講演抄録集 136 - 136 2019.7

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Failure of complete hatching of intracytoplasmic sperm injection-derived vitrified–thawed human blastocyst by cell herniation via small slit and insufficient expansion despite ongoing cell proliferation

Human Reproduction. 2019;34(Supplement 1):i210-211. 34 ( Supplement 1 ) i210 - i211 2019.7

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ICSI由来ヒト胚盤胞は細胞増殖を認めるも、拡張が不十分となり透明帯からの完全脱出率が低下する

井上岳人, 田口朝優姫, 植村弥希子, 平尾佳代子, 辻本賀子, 宮崎和典, 山下能毅

Journal of Mammalian Ova Research 36 ( 1 ) S62 - S62 2019.4

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胚培養士セッション「ラボワークの百聞と一見」 IVF/ICSI実施の適切なタイミングについて

井上岳人

Journal of Mammalian Ova Research 36 ( 1 ) S13 - S13 2019.4

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ICSIはヒト胚盤胞の透明帯からの完全脱出率を低下させる：in vitro study

井上岳人, 田口朝優姫, 平尾佳代子, 辻本賀子, 植村弥希子, 宮崎和典, 山下能毅

日本生殖発生医学会第14回学術集会 13 - 13 2019

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The effects of duty cycles of electrical stimulation on the expressions of pro-differentiation factors on human dermal fibroblasts

Mikiko Uemura, Masaharu Sugimoto, Yoshiyuki Yoshikawa, Terutake Hiramatsu, Taketo Inoue, Masafumi Matsuo

2019

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Influence of Location of Botulinum Toxin Type A Injection on Improvement in Walking Ability

Mikiko Uemura, Ruri Kitamura, Wataru Aoyama, Sonomi Nakagawa, Rie Sawai, Daiji Tsutsui, Kasumi Kashiwagi, Takuya Okada, Yasuhisa Yoshida, Taketo Inoue, Shigeatsu Natsume

2019

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胚選択における自動解析評価システムEevaとタイムラプスインキュベーターGeri+の有用性の検討

山下能毅, 田口朝優姫, 井上岳人, 平尾佳代子, 辻本賀子, 山本修二, 宮崎和典, 穀内香奈, 中村奈津穂, 大道正英

日本生殖医学会雑誌 64 ( 4 ) 259 - 259 2019

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マウス敗血症モデルにおける肺でのneutrophil extracellular taps(NETs)形成とその性差におけるIL-18の関与について

石川倫子, 井上岳人, 小谷穣治, 藤原智弘, 小濱圭祐, 新田翔, 長谷川佳奈, 大家宗彦, 平田淳一

日本救急医学会雑誌 30 ( 9 (Web) ) 705 - 705 2019

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ICSIは胚盤胞の透明帯からの完全脱出率を低下させる

井上岳人, 井上岳人, 田口朝優姫, 平尾佳代子, 辻本賀子, 山本修士, 植村弥希子, 宮崎和典, 山下能毅

日本生殖医学会雑誌 63 ( 3 ) 283 - 283 2018.8

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High concentrations of interleukin-18 induce Leydig cell apoptosis and steroidogenesis disorder

Taketo Inoue, Michiko Aoyama-Ishikawa, Mikiko Uemura, Hayato Yamashita, Yuka Koga, Makoto Usami, Joji Kotani

Human Reproduction 33 ( Supplement 1 ) i154 - i154 2018.7

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Follicular fluid volume associates with membrane stretchability of human metaphase II oocyte following GnRH agonist protocol during ICSI

Taketo Inoue, Sayumi Taguchi, Shuji Yamamoto, Kayoko Hirao, Yoshiko Tsujimoto, Mikiko Uemura, Kazunori Miyazaki, Yoshiki Yamashita

The 8th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2018) Abstract Book 170 - 170 2018.4

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GnRH agonist法により得られた成熟卵子細胞膜伸展性と卵胞液量

井上岳人, 井上岳人, 辻本賀子, 山本修士, 田口朝優姫, 平尾佳代子, 植村弥希子, 井川佳世恵, 宮崎和典, 山下能毅

日本生殖医学会雑誌 62 ( 4 ) 461 - 461 2017.10

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Follicular fluid volume affects membrane stretchability of human metaphase II oocyte following GnRH antagonist protocol during ICSI

Taketo Inoue, Sayumi Taguchi, Yoshiko Tsujimoto, Shuji Yamamoto, Kayoko Hirao, Mikiko Uemura, Kayoe Ikawa, Kazunori Miyazaki, Yoshiki Yamashita

The 11th Congress of the Pacific Society for Reproductive Medicine. Abstract Book 84 - 84 2017.10

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High-dose interleukin-18 induces mice Leydig cell apoptosis and reduces steroidogenesis

The 11th Congress of the Pacific Society for Reproductive Medicine. Abstract Book 99 - 99 2017.10

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interleukin‐18の動態から見るマウス全身性炎症後の雄性不妊

井上岳人, 井上岳人, 石川倫子, 石川倫子, 鴨志田伸吾, 山下勇人, 植村弥希子, 宇佐美眞, 小谷穣治

日本救急医学会雑誌 28 ( 9 ) 709 - 709 2017.9

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Novel indicator for intracytoplasmic sperm injection?

Taketo Inoue, Mikiko Uemura

BIT’s 5th International Congress of Obstetrics and Gynaecology. Conference Abstract Book 97 - 97 2017.5

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直流パルス電流の刺激周波数が線維芽細胞の遊走およびFocal adhesion kinaseに与える影響

植村弥希子, 前重伯壮, 井上岳人, 古賀由華, 杉元雅晴, 吉川義之, 宇佐美眞

日本物理療法学会学術大会抄録集 24回 26 - 26 2016.10

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DOES INTERLEUKIN-18 PARTICIPATE IN HYPERGLYCEMIA IN SEPTIC MICE?

Hayato Yamashita, Michiko Ishikawa, Taketo Inoue, Makoto Usami, Atsunori Nakao, Joji Kotani

SHOCK 46 ( 4 ) 29 - 29 2016.10

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HIGH-DOSE INTERLEUKIN-18 INDUCES MICE LEYDIG CELL APOPTOSIS VIA THE DEATH RECEPTOR PATHWAY

Taketo Inoue, Michiko Ishikawa, Mikiko Uemura, Hayato Yamashita, Yuka Koga, Makoto Usami, Joji Kotani

SHOCK 46 ( 4 ) 63 - 63 2016.10

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高濃度のinterleukin-18はデスレセプター経路を介しライディッヒ細胞アポトーシスを誘導する

井上岳人, 石川倫子, 植村弥希子, 山下勇人, 古賀由華, 小谷穣治, 宇佐美眞

第34回日本受精着床学会総会・学術講演会．プログラム・講演抄録集 187 - 187 2016.9

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卵胞液量は卵子細胞膜低伸展性の要因となる

井上岳人, 山下能毅, 辻本賀子, 小早菜月, 山本修士, 田口朝優姫, 平尾佳代子, 井川佳世恵, 宮崎和典

第34回日本受精着床学会総会・学術講演会．プログラム・講演抄録集 178 - 178 2016.9

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ICSIにおけるHyaluronic acid binding assayの有効性の検討

中村奈津穂, 山下能毅, 井川佳代恵, 井上岳人, 辻本賀子, 山本修士, 田口朝優姫, 宮崎和典, 寺井義人, 大道正英

第34回日本受精着床学会総会・学術講演会．プログラム・講演抄録集 208 - 208 2016.9

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Interleukin-18 and apoptosis of mice Leydig cell during lipopolysaccharide-induced acute inflammatory condition

Taketo Inoue, Michiko Ishikawa, Mikiko Uemura, Hayato Yamashita, Yuka Koga, Atsunori Nakao, Joji Kotani, Makoto Usami

Human Reproduction. 31 ( Supplement 1 ) i151 - i151 2016.7

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アンチトロンビンはNeutrophil extracellular traps形成を抑制する

石川倫子, 山下勇人, 岡伸樹, 山田太平, 滿保直美, 井上岳人, 藤崎宣友, 小谷穣治

第23回外科侵襲とサイトカイン研究会．プログラム・抄録集 22 - 22 2016.7

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高濃度のinterleukin-18はライディッヒ細胞のアポトーシスを誘起する

井上岳人, 石川倫子, 植村弥希子, 山下勇人, 古賀由華, 小谷穣治, 宇佐美眞

第23回外科侵襲とサイトカイン研究会．プログラム・抄録集 33 - 33 2016.7

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Butyrate,DHA induce apoptosis and regulate apoptosis-related factors in keloid fibroblasts

Mikiko Uemura, Maeshige Noriaki, Akane Ochi, Yuka Koga, Michiko Aoyama-Ishikawa, Hayato Yamashita, MIYOSHI MAKOTO, Taketo Inoue, Hiroto Terashi, Makoto Usami

Wound Repair and Regeneration 24 ( 4 ) A36 2016.7

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SAH患者では術後早期に端座位を行うことでADLが改善し入院期間が短縮される

植村弥希子, 井上岳人, 桑田真吾, 夏目重篤, 松本洋明

第41回日本脳卒中学会 2016.4

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interleukin‐18はデスレセプター経路を活性化し,ライディッヒ細胞のアポトーシスを誘導する

井上岳人, 井上岳人, 井上岳人, 石川倫子, 石川倫子, 植村弥希子, 山下勇人, 古賀由華, 小谷穣治, 宇佐美眞

日本アンドロロジー学会総会記事 35th 196‐197 2016

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精巣男性ホルモン産生細胞におけるアポトーシスへのエンドトキシン及びIL‐18の関与

井上岳人, 井上岳人, 石川倫子, 植村弥希子, 山下勇人, 古賀由華, 宇佐美眞, 小谷穣治

日本エンドトキシン・自然免疫研究会プログラム・抄録集 22nd 22 - 34 2016

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エンドトキシン血症における筋萎縮に対するtributyrinによる抑制効果

西山雄也, 三好真琴, 甲斐元規, 梶田歩, 石川(青山, 倫子, 前重伯壮, 山下勇人, 井上岳人, 植村実希子, 古賀由華, 宇佐美眞, 宇佐美眞

機能性食品と薬理栄養 9 ( 4 ) 259 - 259 2015.12

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急性炎症下精巣における内因性IL-18の役割は生殖細胞アポトーシスの誘導から抑止へ変化する

井上岳人, 石川倫子, 鴨志田伸吾, 西野哲, 笹野真希, 岡伸樹, 山下勇人, 甲斐元規, 中尾篤典, 小谷穣治, 宇佐美眞

第22回外科侵襲とサイトカイン研究会．プログラム・抄録集 22 - 22 2015.12

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12週間ラード含有高脂肪食が急性炎症下の肝組織中PPARαとPPARγ発現を上昇させる

甲斐元規, 三好真琴, 西山雄也, 梶田歩, 石川(青山)倫子, 前重伯壮, 井上岳人, 植村弥希子, 山下勇人, 古賀由華, 宇佐美眞

第6回機能油脂懇話会（第17回CLA懇話会) 2015.11

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The role of Endogenous Interleukin-18 on Glucose Metabolism during Acute Inflammation in a Septic Mouse Model

Hayato Yamashita, Michiko Ishikawa-Aoyama, Taketo Inoue, Makoto Miyoshi, Noriaki Maeshige, Makoto Usami, Atsunori Nakao, Joji Kotani

2015.11

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Skeletal Muscle Atrophy is Induced at Early Phase in Endotoxemic Rats and Oral Administration of Tributyrin Attenuates the Atrophy

Y. Nishiyama, M. Miyoshi, M. Kai, M. Aoyama-Ishikawa, N. Maeshige, T. Inoue, M. Uemura, H. Yamashita, Y. Koga, M. Usami

Clinical Nutrition 34 S50 - S51 2015.9

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DOI： 10.1016/s0261-5614(15)30225-9

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Up-Regulation of Hepatic Ppara and Pparγ in Endotoxemic Rats by Feeding Lard-Rich High-Fat Diet for 12 Weeks

M. Kai, M. Fujiwara, M. Miyoshi, Y. Nishiyama, M. Aoyama-Ishikawa, N. Maeshige, T. Inoue, M. Uemura, H. Yamashita, Y. Koga, M. Usami

Clinical Nutrition 34 S38 - S38 2015.9

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DOI： 10.1016/s0261-5614(15)30190-4

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The effects of butyrate/DHA on apoptosis and apoptosis related factors in keloid fibroblasts

Noriaki Maeshige, Akane Ochi, Yuka Koga, Mikiko Uemura, Michiko Aoyama-Ishikawa, Hayato Yamashita, Makoto Miyoshi, Taketo Inoue, Mayu Fujiwara, Motoki Kai, Yuya Nishiyama, Hiroto Terashi, Makoto Usami

203 - 203 2015.5

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Early ambulation improves activities of daily living and reduces hospitalization in aneurysmal subarachnoid hemorrhage patients

Mikiko Uemura, Shingo Yoshikawa, Noriaki Maeshige, Taketo Inoue, Shigeatsu Natsume, Yasuhisa Yoshida, Hiroaki Matsumoto

World Confederation for Physical Therapy (WCPT) Congress 2015 2015.5

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The role of endogenous IL-18 in testicular germ cell apoptosis shifts from pro-apoptotic to anti-apoptotic depending on the inflammatory state

Taketo Inoue, Michiko Aoyama-Ishikawa, Maki Sasano, Nobuki Oka, Hayato Yamashita, Shingo Kamoshida, Atsunori Nakao, Joji Kotani, Makoto Usami

366 - 366 2015.4

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The evaluation of sperm hyaluronic acid binding ability as predictive for clinical success of intracytoplasmic sperm injection

Natsuki Kohaya, Yoshiki Yamashita, Taketo Inoue, Sayumi Taguchi, Yoshiko Tujimoto, Shuji Yamamoto, Kazunori Miyazaki, Yoshito Terai, Masahide Ohmichi

230 - 230 2015.4

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Testicular Germ Cell Apoptosis is regulated by Endogenous Interleukin-18

Taketo Inoue, Michiko Aoyama-Ishikawa, Shingo Kamoshida, Hayato Yamashita, Atsunori Nakao, Joji Kotani, Makoto Usami

52 - 52 2015.3

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ケロイド線維芽細胞に対する酪酸・DHAのapoptosis誘導効果

植村弥希子, 前重伯壮, 越智茜, 古賀由華, 青山倫子, 山下勇人, 三好真琴, 井上岳人, 寺師浩人, 宇佐美眞

日本創傷治癒学会プログラム・抄録集 44回 48 - 48 2014.12

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4週間あるいは12週間ラード含有高脂肪食摂食による急性炎症下の肝組織中脂肪酸分画,脂肪酸酸化・合成酵素の変動

甲斐元規, 藤原麻有, 三好真琴, 西山雄也, 青山倫子, 前重伯壮, 井上岳人, 植村弥希子, 山下勇人, 高橋路子, 濱田康弘, 濱田康弘, 宇佐美眞, 宇佐美眞

機能性食品と薬理栄養 8 ( 5 ) 439 - 439 2014.12

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ラード含有高脂肪食投与によるラット肝障害下の脂肪酸分画の変動

甲斐元規, 藤原麻有, 西岡田亜矢, 三好真琴, 西山雄也, 青山倫子, 前重伯壮, 山下勇人, 井上岳人, 高橋路子, 濱田康弘, 宇佐美眞

日本栄養・食糧学会大会講演要旨集 68回 287 - 287 2014.4

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12週間の高脂肪食投与によるラットエンドトキシン血症下の肝組織中脂質エディエーターと脂肪酸代謝酵素の経時変化

西山雄也, 西岡田亜矢, 藤原麻有, 三好真琴, 甲斐元規, 青山倫子, 山下勇人, 井上岳人, 前重伯壮, 高橋路子, 濱田康弘, 有田誠, 宇佐美眞

日本栄養・食糧学会大会講演要旨集 68回 281 - 281 2014.4

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Tributyrin経口投与は健常ラット回腸粘膜のTLR2 mRNA発現を増強する

三好真琴, 藤原麻有, 青山(石川)倫子, 甲斐元規, 西山雄也, 山下勇人, 前重伯壮, 井上岳人, 古賀由華, 増田弘明, 植村弥希子, 宇佐美眞

日本栄養・食糧学会大会講演要旨集 68回 158 - 158 2014.4

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Tributyrin経口投与によるエンドトキシン血症下の腸管障害抑制と生存率改善

三好真琴, 藤原麻有, 青山倫子, 西岡田亜矢, 甲斐元規, 西山雄也, 山下勇人, 前重伯壮, 井上岳人, 宇佐美眞

静脈経腸栄養 29 ( 1 ) 297 - 297 2014.1

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マウス急性エンドトキシン血症におけるアンチトロンビンⅢの後投与は生存率を改善する

山下勇人, 石川倫子, 岡伸樹, 増田弘明, 藤原麻有, 井上岳人, 宇佐美眞, 小谷穣治

第20回外科侵襲とサイトカイン研究会．プログラム・抄録集 29 - 29 2013.12

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マウス急性エンドトキシン血症下の血糖値変動およびインスリンシグナル伝達における雌雄の検討

増田弘明, 石川倫子, 山内千里, 山下勇人, 前重伯壮, 三好真琴, 井上岳人, 宇佐美眞, 中尾篤典, 小谷穣治

第20回外科侵襲とサイトカイン研究会．プログラム・抄録集 28 - 28 2013.12

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急性炎症後の回復期における精巣生殖細胞のアポトーシスとIL‐18の関与

井上岳人, 青山倫子, 西野哲, 笹野真希, 岡伸樹, 山下勇人, 上田敬博, 鴨志田伸吾, 宇佐美眞, 小谷穣治

日本生殖医学会雑誌 58 ( 4 ) 297 - 297 2013.10

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37°Cで輸送した卵子から得られたDay7凍結胚盤胞により妊娠に至った1症例

井上岳人, 小野吉行, 米澤由紀子, 藤原卓夫, 野原当, 三村治, 岸淳二, 江見信之

日本生殖医学会雑誌 58 ( 4 ) 417 - 417 2013.10

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マウス急性エンドトキシン血症下の高血糖へ及ぼすIL‐18の関与の検討

山下勇人, 青山倫子, 岡伸樹, 井上岳人, 前重伯壮, 三好真琴, 置村康彦, 宇佐美眞, 小谷穣治

Shock 28 ( 1 ) 59 - 59 2013.4

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急性炎症後の回復期における精巣生殖細胞のアポトーシスとIL‐18の役割

井上岳人, 青山倫子, 西野哲, 笹野真希, 岡伸樹, 山下勇人, 上田敬博, 鴨志田伸吾, 宇佐美眞, 小谷穣治

Shock 28 ( 1 ) 60 - 60 2013.4

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エンドトキシン血症発症後の精巣生殖細胞アポトーシスへの内因性IL‐18の役割

井上岳人, 石川倫子, 西野哲, 笹野真希, 岡伸樹, 山下勇人, 鴨志田伸吾, 中尾篤典, 宇佐美眞, 小谷穣治

日本エンドトキシン・自然免疫研究会プログラム・抄録集 19th 51 2013

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IL-18 suppressed hypereglycemia in hyperacute phase of endotoxemia

Hayato Yamashita, Michiko Aoyama-Ishikawa, Taketo Inoue, Mayu Fujiwara, Noriaki Maeshige, Makoto Miyoshi, Yasuhiko Okimura, Yasuhiro. Hamada, Makoto Usami, Joji Kotani

Clinical Nutrition 32 ( Supplement 1 ) S31 - S31 2013

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The endogenous interleukin-18 regulates testicular germ cell apoptosis in recovery period of endotoxin-induced acute inflammation

Taketo Inoue, Michiko Aoyama, Satoshi Nishino, Maki Sasano, Nobuki Oka, Hayato Yamashita, Takahiro Ueda, Shingo Kamoshida, Makoto Usami, Joji Kotani

Shock 39 ( Supplement 2 ) 103 - 103 2013

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急性炎症下における血糖変動へのIL-18の関与

山下勇人, 青山倫子, 高原美樹, 山内千里, 岡伸樹, 田淵寛人, 井上岳人, 前重伯壮, 三好真琴, 沖村康彦, 宇佐美眞, 小谷穣治

第19回外科侵襲とサイトカイン研究会．プログラム・抄録集 23 - 23 2012.12

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Lipopolysaccharide (LPS) 刺激によるヒト好中球アポトーシス抑制に対するアンチトロンビンⅢ (ATⅢ) の改善効果と性差

岡伸樹, 上田敬博, 青山倫子, 井上岳人, 山下勇人, 前重伯壮, 宇佐美眞, 小谷穣治

第19回外科侵襲とサイトカイン研究会．プログラム・抄録集 48 - 48 2012.12

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後天性精子障害の病態解析 Interleukin-18は急性炎症下の精巣における生殖細胞のアポトーシスを制御する(The role of interleukin-18 on testicular germ cell apoptosis during acute inflammation)

井上岳人, 青山倫子, 西野哲, 笹野真希, 岡伸樹, 山下勇人, 上田敬博, 鴨志田伸吾, 宇佐美眞, 小谷穣治

Reproductive Immunology and Biology 27 ( 1-2 ) 53 - 53 2012.11

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Gender difference of the role of Il-18 on intestinal mucosal mRNA expression during endotoxemia

Michiko Aoyama, Masahiko Kouzaki, Taketo Inoue, Nobuki Oka, Hayato Yamashita, Makoto Usami, Takahiro Ueda, Joji Kotani

The 12th Biennial International Endotoxin & Innate Immunity Society (IEIIS) meeting. Program &Abstracts 162 - 162 2012.10

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The relationship between cell-free plasma DNA concentration and mortility of ICU patients

Michiko Aoyama, Joji Kotani, Takahiro Ueda, Noriaki Maeshige, Makoto Miyoshi, Nobuki Oka, Taketo Inoue, Makoto Usami

Shock 37 ( Supplement 1 ) 111 - 111 2012.6

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The role of interleukin-18 in testicular germ cell apoptosis during endotoxemia.

Taketo Inoue, Satoshi Nishino, Michiko Aoyama, Maki Sasano, Nobuki Oka, Shingo Kamoshida, Makoto Usami, Joji Kotani

Shock 37 ( Supplement 1 ) 97 - 97 2012.6

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The effect of antithrombin III on neutrophil apoptosis in endotoxin stimulation

Nobuki Oka, Takahiro Ueda, Michiko Aoyama, Taketo Inoue, Makoto Usami, Joji Kotani

Shock 37 ( Supplement 1 ) 72 - 72 2012.6

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エンドトキシン血症下の精巣における生殖細胞アポトーシスとIL‐18の関与

井上岳人, 青山倫子, 西野哲, 笹野真希, 神前雅彦, 岡伸樹, 藤原麻有, 上田敬博, 鴨志田伸吾, 宇佐美眞, 小谷穣治

Shock 27 ( 1 ) 79 - 79 2012.4

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エンドトキシン刺激下の好中球アポトーシスに対するアンチトロンビンIIIの効果

岡伸樹, 青山倫子, 上田敬博, 井上岳人, 前重伯壮, 藤原麻有, 神前雅彦, 三好真琴, 寺嶋真理子, 宇佐美眞, 小谷穣治

Shock 27 ( 1 ) 78 - 78 2012.4

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急性炎症下の精巣における生殖細胞アポトーシスとinterleukin‐18の関与

井上岳人, 青山倫子, 西野哲, 笹野真希, 神前雅彦, 岡伸樹, 藤原麻有, 上田敬博, 鴨志田伸吾, 宇佐美眞, 小谷穣治

日本アンドロロジー学会総会記事 31st 149 - 150 2012

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低温輸送した精巣精子でICSIを行い妊娠・出産に至った2症例

井上岳人, 杉本浩伸, 大久保和俊, 江見信之, 米澤由紀子, 小島謙二, 岸淳二, 中村光彰, 小野吉行

日本生殖医学会雑誌 56 ( 4 ) 377 - 377 2011.10

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7種類の生薬で構成した漢方薬を服用することによる胚発生率の改善

井上岳人, 米澤由紀子, 江見信之, 岸淳二, 大井道順, 小野吉行

日本生殖医学会雑誌 56 ( 4 ) 371 - 371 2011.10

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The Effect of IL-18 and The Gender Difference on The Inducible No Synthase (iNOS) in Jejunum During Endotoxemia

Masahiko Kouzaki, Michiko Aoyama, Taketo Inoue, Miki Takahama, Chisato Yamauchi, Noriaki Maeshige, Makoto Miyoshi, Takahiro Ueda, Makoto Usami, Joji Kotani

Shock 35 ( Supplement 1 ) 43 - 43 2011.6

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エンドトキシン刺激下での好中球アポトーシスに対するアンチトロンビンIII(AT III)の効果

岡伸樹, 青山倫子, 井上岳人, 神前雅彦, 高原美樹, 山内千里, 前重伯壮, 三好真琴, 上田敬博, 寺嶋真理子, 宇佐美眞, 小谷穣治

日本エンドトキシン・自然免疫研究会プログラム・抄録集 17th 33 2011

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エンドトキシン血症下における骨髄好中球の遊走能におけるIL‐18の役割について

松岡未悠, 青山倫子, 高原美樹, 山内千里, 神前雅彦, 井上岳人, 藤原麻有, 前重伯壮, 三好真琴, 上田敬博, 小谷穣治, 宇佐美眞

日本エンドトキシン・自然免疫研究会プログラム・抄録集 17th 31 2011

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エンドトキシン血症下腸管粘膜におけるiNOSmRNA発現の雌雄差

井上岳人, 神前雅彦, 青山倫子, 前重伯壮, 三好真琴, 上田敬博, 寺嶋真理子, 宇佐美眞, 小谷穣治

第17回外科侵襲とサイトカイン研究会．プログラム・抄録集 19 - 19 2010.12

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凍結融解マウス精子の体外受精時の精子前培養培地内の精子濃度と受精成績の関係

井上岳人, 中務胞, 山村研一, 中潟直己

第40回日本実験動物技術者協会総会．講演要旨集 88 - 88 2006.10

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新規凍結保存液を用いたC57BL/6およびC57BL/6由来キメラマウス精子の凍結保存

井上岳人, 中務胞, 山村研一, 中潟直己

第53回日本実験動物学会総会．講演要旨集 186 - 186 2006.5

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In vitro fertilization rates of frozen C57BL/6 spermatozoa

Taketo Inoue, Ena Nakatsukasa, Kenichi Yamamura, Naomi Nakagata

Experimental Animals 55 ( 3 ) S97 - S97 2006.4

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マウスの再過排卵処理に関する研究

井上岳人, 中務胞, 小野洋充, 北村薫, 中潟直己, 山村研一

第51回日本実験動物学会総会．講演要旨集 237 - 237 2004.5

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Studies on induction of mouse superovulation

Taketo Inoue, Ena Nakatsukasa, Hiromitsu Ono, Kaoru Kitamura, Naomi Nakagata, Kenichi Yamamura

53 ( 3 ) S61 - S61 2004.4

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Presentations

胚培養士のキャリア展開：基礎研究や関連分野へ広がる学際的アプローチ

井上岳人

生殖補助医療特別セミナー 2026.3.4 岡山大学生殖補助医療技術教育研究センター

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Venue：岡山大学

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卵子凍結周期におけるラボセッティング Invited

井上岳人

The 7th Clinical Embryology Seminar 2024.9.21

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前核期受精卵における核小体前駆体の動態とART由来胚の発生 Invited

井上岳人

第4回絹谷産婦人科胚培養士研修会 2024.9.7

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培養室業務の実際２

井上岳人

2024年度第23回生殖補助医療胚培養士資格認定講習会・審査会 2024.3

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前核内動態に着目したART由来胚発生の指標 Invited

井上岳人

vivola-Insights Webセミナー 2024.2.28

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不妊治療に関連する先進医療技術への取り組み Invited

井上岳人

第1回大阪ARTセミナー 2023.9.5

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保険適用下における最適なラボワークを考える Invited

井上岳人

第24回横浜ART研究会 2023.8.26

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前核内動態に着目したART由来胚発生の指標 Invited

井上岳人

第32回神戸MARE研究会 2023.7.8

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培養室業務の実際２

井上岳人

2023年度第22回生殖補助医療胚培養士資格認定講習会・審査会 2023.3

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不妊治療の保険適用に伴うラボワークの変化と対応 Invited

井上岳人

第5回Clinical Embryology Seminar 2022.11.27

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ヒアルロン酸結合能による精子選択の重要性と臨床成績 Invited

井上岳人

第39回平成不妊研究会 2022.11.10

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培養室業務の実際２

井上岳人

2022年度第21回生殖補助医療胚培養士資格認定講習会・審査会 2022.3

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ヒアルロン酸結合による成熟精子選択の重要性とその臨床成績 Invited

井上岳人

オリジオ・ジャパン主催ウェビナー 2021.10.21

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ヒト雄性前核内の核小体前駆体移動速度は生児獲得/継続妊娠の予測因子となる

井上岳人, 田口朝優姫, 植村弥希子, 辻本賀子, 山本修士, 平尾佳代子, 宮崎和典, 山下能毅

第14回大阪ARTカンファレンス 2021.9.4

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核小体前駆体の移動速度とARTによる生児獲得 Invited

井上岳人

生殖補助医療技術者のためのリカレントセミナー from 岡大ARTセンター 2021.3.28

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Presentation type：Symposium, workshop panel (nominated)

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タイムラプスインキュベータの導入は胚評価をどう変えるのか． Invited

井上岳人

2nd Clinical Embryology Seminar 2019.9.22

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全身性急性炎症後の雄性不妊からいかに妊娠・出産へつなげるか～基礎研究・臨床研究の知見をまじえて～ Invited

井上岳人

第22回神戸MARE研究会 2018.7

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自動解析評価システムEevaによるMorphologyとKineticsの融合

山下能毅, 井上岳人

第59回日本卵子学会 2018.5

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Awards

優秀演題賞（フェリング・ファーマ賞）

2022.1 第27回日本臨床エンブリオロジスト学会ワークショップ・学術大会

井上岳人

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学術奨励賞

2019.5 第60回日本卵子学会学術集会

井上岳人

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Research Projects

Gut-lung axis and optimal intestinal oxygenation in hemorrhagic shock

Grant number：24K12145 2024.04 - 2027.03

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

藤崎宣友, 井上岳人, 石川倫子, 小濱圭祐

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Grant amount：\4290000 （ Direct expense: \3300000 、 Indirect expense：\990000 ）

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女性ホルモン類似物質はCOVID -19肺炎の重症化を抑制できるか

Grant number：23K08471 2023.04 - 2027.03

日本学術振興会科学研究費助成事業基盤研究(C)

村上博基, 石川倫子, 井上岳人, 小濱圭祐, 山田太平, 平田淳一

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Grant amount：\4550000 （ Direct expense: \3500000 、 Indirect expense：\1050000 ）

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全身性急性炎症状態が卵巣機能へ及ぼす影響と魚油投与効果の解明

Grant number：23K08488 2023.04 - 2026.03

日本学術振興会科学研究費助成事業基盤研究(C)

井上岳人, 石川倫子, 小濱圭祐, 藤崎宣友

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Grant amount：\4680000 （ Direct expense: \3600000 、 Indirect expense：\1080000 ）

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女性ホルモン類似物質のNETs抑制効果は敗血症性DICの回避に有効か？

Grant number：23K08435 2023.04 - 2026.03

日本学術振興会科学研究費助成事業基盤研究(C)

石川倫子, 東英樹, 村上博基, 井上岳人, 藤崎宣友, 小濱圭祐, 山田太平

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Grant amount：\4810000 （ Direct expense: \3700000 、 Indirect expense：\1110000 ）

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女性ホルモン類似物質による敗血症時の過活性化好中球機能制御についての検討

Grant number：20K09298 2020.04 - 2023.03

日本学術振興会科学研究費助成事業基盤研究(C) 基盤研究(C)

石川倫子, 井上岳人, 小濱圭祐

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Grant amount：\4160000 （ Direct expense: \3200000 、 Indirect expense：\960000 ）

敗血症予後には性差が存在し、男性ホルモンは予後悪化に、女性ホルモンは予後改善に効果的である。本研究は女性ホルモン類似物質であるエクオールが過剰となった好中球機能を一時的に抑制し、敗血症における好中球起因の臓器障害を軽減するかを明らかにすることを目的として、臓器障害の一因となる好中球機能として好中球細胞外トラップ(Netrophil extracellular traps; NETs)に着目している。
本研究では①ヒト好中球のNETs産生におけるエクオールの効果、②性別（性ホルモン）がエクオールの効果に及ぼす影響、③エクオールによる敗血症病態でのNETs制御は可能か、について検討する予定であるが、2020年度は①を目的として、エクオールがNETsに及ぼす影響をin vitroにてヒト好中球を用いて確認した。結果、エクオールはヒト好中球NETsをlipopolysaccharide（LPS）刺激下、またはLPSおよび血小板存在下のいずれにおいても抑制する結果を得た。また、in vitroにおける濃度依存についても検討し、LPS単独投与の場合にはエクオール濃度が高くなるにつれNETs抑制も顕著となることを発見した。それらの結果から、濃度としては妊娠時の女性ホルモン量に相当するような濃度が効果的と考えられた。現在そのメカニズムを検討すべく、関連蛋白質などの測定を行っている。

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全身性急性炎症後の男性生殖機能改善を目的とした基礎検討

Grant number：19K18371 2019.04 - 2023.03

日本学術振興会科学研究費助成事業若手研究若手研究

井上岳人

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Grant amount：\4160000 （ Direct expense: \3200000 、 Indirect expense：\960000 ）

我々は急性炎症時に精巣内で発現が上昇する過剰なIL-18により生殖細胞およびライディッヒ細胞のアポトーシスが誘起される可能性を示してきた。平成31年度は、まず、マウスセルトリ細胞由来TM4細胞を用いてin vitroで炎症刺激（lipopolysaccaride: LPS）を行い、セルトリ細胞のIL-18発現に変化があるのか検証した。結果、セルトリ細胞のIL-6等の炎症性サイトカインの発現は増加し、炎症反応は惹起されるものの、IL-18の発現は増加しなかった（炎症刺激下でライディッヒ細胞のIL-18の発現は増加せず、マクロファージのIL-18の発現は増加した）。従って、急性炎症下での精巣内のIL-18濃度の上昇は免疫細胞由来である可能性が推察され、精巣に浸潤する免疫細胞由来のIL-18を抑制することが全身性炎症下に起因する精巣炎の治療ターゲットになりうるのではないかと考えられた。次に、炎症刺激後、どの時点でTM4細胞アポトーシス関連因子の発現に変化があるのか経時的に検証した。LPS刺激によりデスレセプター経路関連因子の発現が、刺激1時間後で上昇し、刺激12時間で発現が刺激0時間のベースラインと差がなくなることが明らかとなった。ライディッヒ細胞では刺激12時間後でデスレセプター経路関連因子の発現が上昇しており、精巣細胞において発現が増加されるまでの時間が異なることが明らかとなった。本研究により平成31年度予定していた「IL-18とセルトリ細胞のアポトーシスシグナル伝達経路との関係性の検証」を検討するための基盤となる結果が得られた。

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IL-18は全身性急性炎症に起因する精巣炎治療ターゲットとなりうるか

2016.04 - 2019.03

科学研究費助成事業若手研究(B)

井上岳人

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Authorship：Principal investigator Grant type：Competitive

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