Faculty Profiles - HAGIYA Hideharu

Papers - HAGIYA Hideharu

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Acute Generalized Exanthematous Pustulosis Caused by Daptomycin in a Critically Ill Burn Victim Reviewed

Hideharu Hagiya, Maya Kimura, Toru Miyamoto, Yuto Haruki, Fumio Otsuka

INTERNAL MEDICINE 53 ( 5 ) 511 - 514 2014

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN SOC INTERNAL MEDICINE

Acute generalized exanthematous pustulosis (AGEP) is a self-limiting type of drug eruption that frequently occurs as a reaction to antibiotics, particularly penicillins or macrolides. Daptomycin (DAP) is a newly developed antibiotic that specifically targets methicillin-resistant Staphylococcus aureus infection. We herein present the case of a 77-year-old severe burn victim who was diagnosed with DAP-induced AGEP while receiving treatment in an intensive care unit. Although rare, physicians should be aware that the administration of DAP can cause AGEP, which may complicate the clinical course of patients with a high fever and inflammation.

DOI： 10.2169/internalmedicine.53.0679

Rhombencephalitis Caused by Listeria monocytogenes Reviewed

Hideharu Hagiya, Fumio Otsuka

INTERNAL MEDICINE 53 ( 6 ) 639 - 640 2014

Comprehensive Analysis of Systemically Disseminated ST8/non-USA300 type Community-acquired Methicillin-resistant Staphylococcus aureus Infection Reviewed

Hideharu Hagiya, Junzo Hisatsune, Taro Kojima, Sumiko Shiota, Hiromichi Naito, Shingo Hagioka, Naoki Morimoto, Fumio Otsuka, Motoyuki Sugai

INTERNAL MEDICINE 53 ( 8 ) 907 - 912 2014

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN SOC INTERNAL MEDICINE

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is genetically heterogeneous and various genotypes are spreading worldwide. We herein report a case of systematically disseminated Japan-intrinsic CA-MRSA infection that was successfully treated. A genetically identical single strain was isolated from a total of 11 different parts of the patient's body, and the pathogen was found to be multilocus sequence type 8, staphylococcal cassette chromosome mec IV, coagulase type III and negative for both Panton-Valentine leukocidin and arginine catabolic mobile element. The epidemiology and pathogenicity of the Japan-intrinsic CA-MRSA strain remain unknown, and further investigation of this life-threatening organism is warranted.

DOI： 10.2169/internalmedicine.53.1746

Lower Limb Infection in an Infant with Haemophilus influenzae Serotype b

Hideharu Hagiya, Fumio Otsuka

General Medicine 15 ( 1 ) 56 - 58 2014

[Aortic valve-sparing operation for chronic dissecting aneurysm of the sinus of valsalva associated with redissection in a young woman who experienced out-of-hospital cardiac arrest]. Reviewed

Matsumoto M, Kubo Y, Kemmochi R, Yamasawa T, Oka T, Iwasaki J, Morimoto N, Hagioka S, Sugiyama J, Hagiya H

Kyobu geka. The Japanese journal of thoracic surgery 66 ( 9 ) 799 - 802 2013.8

Language：Japanese

A 38-year-old woman was admitted to our hospital because she experienced cardiopulmonary arrest at her wedding;her cardiac beats were resumed 20 min after cardiopulmonary resuscitation performed by her relatives and hotel staffs. Enhanced computed tomography revealed acute aortic redissection in chronic dissecting aneurysm in the right sinus of Valsalva, which was believed to have occurred in the 4th month of pregnancy 2 years before. Echocardiography showed moderate aortic regurgitation. We performed aortic valve-sparing operation and ascending aortic replacement with partial remodeling of the right sinus of Valsalva. She returned to work 2 months later without high-order dysfunction.

Other Link： https://search.jamas.or.jp/default/link?pub_year=2013&ichushi_jid=J00349&link_issn=&doc_id=20130726020008&doc_link_id=1390001288081728128&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390001288081728128&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_2.gif

[Surgical treatment of traumatic aortic rupture]. Reviewed

Yamasawa T, Matsumoto M, Kubo Y, Kemmochi R, Morimoto N, Hagioka S, Sugiyama J, Hagiya H, Nakai M

Kyobu geka. The Japanese journal of thoracic surgery 66 ( 7 ) 537 - 540 2013.7

Language：Japanese

This report focuses on 3 cases of traumatic aortic dissection or rupture at the isthmus. We selected 3 different methods of treatment. In the 1st case, we performed an emergency operation with graft replacement of the proximal descending aorta. In the 2nd case, we performed elective graft replacement 5 months after the rupture under careful blood pressure control. Thirdly, we performed emergency stent grafting at the isthmus, the rupture site. All cases were successfully treated, but it remains difficult to select the method of treatment for multisystem disorder. Our current strategy for traumatic rupture at the isthmus is immediate stent grafting. It will also be a very useful procedure for multisystem trauma.

Systemic varicella-zoster virus infection in two critically ill patients in an intensive care unit Reviewed International journal

Hideharu Hagiya, Maya Kimura, Toru Miyamoto, Fumio Otsuka

VIROLOGY JOURNAL 10 225 - 225 2013.7

Language：English Publishing type：Research paper (scientific journal) Publisher：BIOMED CENTRAL LTD

Varicella-zoster virus (VZV) usually causes localized zoster in adults. However, in immunocompromised patients, it can cause systemic infection accompanied by complications such as pneumonia, encephalitis, and hepatitis. Although most of critically ill patients in intensive care unit (ICU) are immunologically compromised, they are usually not considered to be at risk for systemic VZV infection.
We report two cases of systemic VZV infection occurring in critically ill patients in an ICU. One patient was a 69-year-old man with Streptococcus pneumoniae-induced purpurafulminans, and the other was a 75-year-old woman with severe acute pancreatitis. During the clinical course in the ICU, characteristic vesicles with umbilical fossa appeared diffusely and bilaterally on their face, trunk, and extremities. VZV-specific IgG levels were confirmed to be elevated compared to that of the pre-onset, and a diagnosis of recurrent VZV infection was made in both patients. The patients were treated at the same ICU but did not coincide with each other; therefore a cross-infection was unlikely. They were treated with intravenous acyclovir, but the latter patient eventually died of respiratory failure.
VZV infection can cause a number of serious complications, and can lead to death in some patients. Early detection and proper treatment are needed to prevent the infection from spreading out and save the patients. It might be necessary to consider antiviral prophylaxis against VZV infection for a part of critically ill patients in ICU, although the effectiveness of this approach is yet to be established.

DOI： 10.1186/1743-422X-10-225

Clinical Characteristics of Ochrobactrum anthropi Bacteremia Reviewed International journal

Hideharu Hagiya, Kouhei Ohnishi, Miyako Maki, Naoto Watanabe, Tomoko Murase

JOURNAL OF CLINICAL MICROBIOLOGY 51 ( 4 ) 1330 - 1333 2013.4

Language：English Publishing type：Research paper (scientific journal) Publisher：AMER SOC MICROBIOLOGY

The clinical picture of Ochrobactrum anthropi infection is not well described because the infection is rare in humans and identification of the pathogen is difficult. We present a case of O. anthropi bacteremia that was initially misidentified as Ralstonia paucula and later identified by 16S rRNA sequencing and recA analysis.

DOI： 10.1128/JCM.03238-12

Co-infection with invasive pulmonary aspergillosis and Pneumocystis jirovecii pneumonia after corticosteroid therapy Reviewed International journal

Hideharu Hagiya, Takayoshi Miyake, Yusuke Kokumai, Tomoko Murase, Yasutoshi Kuroe, Hiroyoshi Nojima, Junichi Sugiyama, Hiromichi Naito, Shingo Hagioka, Naoki Morimoto

JOURNAL OF INFECTION AND CHEMOTHERAPY 19 ( 2 ) 342 - 347 2013.4

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER JAPAN KK

A 95-year-old man with chronic obstructive pulmonary disease and chronic hepatitis C virus infection was treated for acute lung injury caused by Chlamydophila pneumoniae with antibiotics and high-dose corticosteroids. In total, 7,500 mg methylprednisolone and 680 mg prednisolone were administered over 21 days. However, respiratory failure progressed, and chest computed tomography (CT) scan showed bilateral ground-glass opacity and cavity-forming consolidation in the right upper lobe. Despite intensive therapy, the patient died of multiple organ failure on day 7. CT-guided necropsy was performed, and pathological examination revealed invasive pulmonary aspergillosis and Pneumocystis jirovecii pneumonia. Invasive pulmonary aspergillosis and P. jirovecii pneumonia are both life-threatening opportunistic fungal infections. Co-infection of these organisms is rare but possible if the patient is in an extremely immunocompromised state. Short-term but high-dose systemic corticosteroid therapy was considered to be the risk factor in this case. We should pay more attention to immunocompromised hosts who might be suffering from co-infection of opportunistic infections. Moreover, we need to consider preventive measures in such high-risk cases.

DOI： 10.1007/s10156-012-0473-9

Delftia acidovorans bacteremia caused by bacterial translocation after organophosphorus poisoning in an immunocompetent adult patient Reviewed International journal

Hideharu Hagiya, Tomoko Murase, Junichi Sugiyama, Yasutoshi Kuroe, Hiroyoshi Nojima, Hiromichi Naito, Shingo Hagioka, Naoki Morimoto

JOURNAL OF INFECTION AND CHEMOTHERAPY 19 ( 2 ) 338 - 341 2013.4

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER JAPAN KK

A 46-year-old woman was transferred to our emergency unit because of impaired consciousness and respiratory failure with the history of excessive pesticide intake. The patient was hypersalivative and had bilateral pupillary miosis. Laboratory results showed markedly decreased cholinesterase. She was intubated and treated in the intensive care unit with the diagnosis of organophosphorus poisoning. The patient had persisted diarrhea, with a high fever and stomach tenderness on day 10. Whole-body contrast enhanced computed tomography revealed a swollen, enhanced small intestinal wall, and blood culture identified Delftia acidovorans. She was diagnosed as D. acidovorans bacteremia, probably caused by bacterial translocation based on the clinical presentation and the exclusion of other sources, and treated well with a total of 8 days of antibiotic therapy. So far as we know, this is the first case of D. acidovorans bacteremia that was presumably caused by bacterial translocation after organophosphorus poisoning in an immunocompetent adult patient.

DOI： 10.1007/s10156-012-0472-x

Disseminated Gonococcal Infection in An Elderly Japanese Man Reviewed

Hideharu Hagiya, Nobuhiko Onishi, Hirotaka Ebara, Yoshihisa Hanayama, Susumu Kokeguchi, Motoko Nose, Nobuchika Kusano, Fumio Otsuka

INTERNAL MEDICINE 52 ( 23 ) 2669 - 2673 2013

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN SOC INTERNAL MEDICINE

We herein present the case of a 69-year-old Japanese man who had unprotected sexual contact with a local commercial sex worker in an East Asian country and was diagnosed as having disseminated gonococcal infection (DGI). The organism was confirmed to be Neisseria gonorrhoeae based on 16S rRNA sequencing and positive results for the cppB gene. This case indicates that a diagnosis of DGI should also be considered in elderly individuals. DGI potentially causes many complications, and the pathogen has recently been reported to be resistant to various antibiotics. Physicians must therefore pay more attention to the possible occurrence of DGI in various clinical settings.

DOI： 10.2169/internalmedicine.52.1033

Is wet swab superior to dry swab as an intranasal screening test? Reviewed International journal

Hideharu Hagiya, Mitsunobu Mio, Tomoko Murase, Keiko Egawa, Yumi Kokumai, Taeko Uchida, Naoki Morimoto, Fumio Otsuka, Sumiko Shiota

Journal of Intensive Care 1 ( 1 ) 10 - 10 2013

Language：English Publishing type：Research paper (scientific journal) Publisher：BioMed Central Ltd.

Methicillin-resistant Staphylococcus aureus is still a great concern, and recognition of the carrier is essential for appropriate infection control in intensive care units. The utility of wet swab compared to dry swab as an intranasal screening test has not been well assessed yet. A comparative study of the wet and dry swab in its ability to detect the organism was performed against critically ill patients, and it was found that there were no statistically significant differences between the two different methods. The wet swab did not show increased sensitivity compared to dry one.

DOI： 10.1186/2052-0492-1-10

Emphysematous liver abscesses complicated by septic pulmonary emboli in patients with diabetes: Two cases Reviewed

Hideharu Hagiya, Yasutoshi Kuroe, Hiroyoshi Nojima, Shinkichi Otani, Junichi Sugiyama, Hiromichi Naito, Susumu Kawanishi, Shingo Hagioka, Naoki Morimoto

Internal Medicine 52 ( 1 ) 141 - 145 2013

Language：English Publishing type：Research paper (scientific journal)

An emphysematous liver abscess is a fatal condition that often occurs in patients with uncontrolled diabetes mellitus. I herein describe two cases of Klebsiella pneumoniae-induced emphysematous liver abscesses complicated by septic pulmonary emboli in patients with poorly controlled diabetes mellitus. Both patients showed hemoglobin A1c levels of more than 10% and did not present with any abdominal symptoms on admission. However, they were diagnosed and successfully treated with percutaneous transhepatic abscess drainage and antibiotics. This fatal disease should be taken into consideration in patients with uncontrolled diabetes mellitus who suffer from prolonged fevers and uncharacteristic general malaise. © 2013 The Japanese Society of Internal Medicine.

DOI： 10.2169/internalmedicine.52.8737

Group A streptococcal meningitis in a patient with palmoplantar pustulosis Reviewed

Hideharu Hagiya, Fumio Otsuka

Internal Medicine 52 ( 23 ) 2675 - 2678 2013

Language：English Publishing type：Research paper (scientific journal)

A 64-year-old man with a 10-year history of palmoplantar pustulosis, a recent history of cranial surgery and a persistent upper airway infection presented with a high fever and deep coma. The patient was diagnosed with Group A Streptococcal meningitis and promptly treated with antibiotics. Although his general condition recovered well, sensorineural hearing loss and facial palsy remained. Group A Streptococcal meningitis is a rare condition, and its typical clinical picture and epidemiological features remain poorly understood. Physicians need to be more aware of this infection, which is extremely rare but frequently causes various complications and yields a high mortality. © 2013 The Japanese Society of Internal Medicine.

DOI： 10.2169/internalmedicine.52.0499

A Fatal Case of Streptococcal Toxic Shock Syndrome due to Streptococcus dysgalactiae subsp equisimilis Possibly Caused by an Intramuscular Injection Reviewed

Hideharu Hagiya, Shunji Okita, Yasutoshi Kuroe, Hiroyoshi Nojima, Shinkichi Otani, Junichi Sugiyama, Hiromichi Naito, Susumu Kawanishi, Shingo Hagioka, Naoki Morimoto

INTERNAL MEDICINE 52 ( 3 ) 397 - 402 2013

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN SOC INTERNAL MEDICINE

An 88-year-old man died of streptococcal toxic shock syndrome due to a group G streptococcus infection that was possibly caused by an intramuscular injection given 30 hours earlier in his right deltoid muscle. The causative pathogen was later identified to be Streptococcus dysgalactiae subsp. equisimilis (stG485). Although providing intramuscular injections is an essential skill of health care workers that is performed daily worldwide, it may constitute a port of entry for pathogens via skin breaches that can cause life-threatening infections. All invasive procedures should be carefully performed, especially when immunologically compromised patients are involved.

DOI： 10.2169/internalmedicine.52.8846

Pyometra Perforation Caused by Actinomyces without Intrauterine Device Involvement. Reviewed International journal

Hagiya H

Case reports in obstetrics and gynecology 2013 658902 - 658902 2013

Language：English Publishing type：Research paper (scientific journal)

An 86-year-old woman with diabetes mellitus and severe decubitus at the sacral and calcaneal regions stemming from poor daily activity was diagnosed with pyometra perforation caused by Actinomyces. No foreign materials, including an IUD, were found inside the uterus. Pyometra is usually caused by Enterobacteriaceae or anaerobes derived from the gastrointestinal tract. The virulence of Actinomyces is rather low, and, in almost all the reported cases of Actinomyces-related pyometra, an intrauterine device (IUD) was involved. Although rare, Actinomyces may be ascribed as a virulent pathogen that causes pyometra in the absence of foreign materials.

DOI： 10.1155/2013/658902

Successful Treatment of Recurrent Candidemia due to Candidal Thrombophlebitis Associated with a Central Venous Catheter Using a Combination of Fosfluconazole and Micafungin Reviewed

Hideharu Hagiya, Hiroki Kajioka

INTERNAL MEDICINE 52 ( 18 ) 2139 - 2143 2013

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN SOC INTERNAL MEDICINE

We herein report the case of an 85-year-old woman presenting with right internal jugular vein candidal thrombophlebitis associated with central venous catheters (CTCVC). The infecting agent was Candida albicans, which caused recurrent candidemia five times in total. Micafungin (MCFG) alone was ineffective; however, the combination of MCFG with fosfluconazole (F-FLCZ) successfully treated the patient without a need for any anticoagulant or surgical therapies. To the extent of our knowledge, this is the first report of CTCVC being successfully treated with a combination of F-FLCZ and MCFG. These new antifungal agents have better efficacy, tolerability and bioavailability; therefore, they can be useful alternatives to classical combination therapies such as amphotericin-B and 5-fluorocytosine.

DOI： 10.2169/internalmedicine.52.0584

Ineffectiveness of Daptomycin in the Treatment of Septic Pulmonary Emboli and Persistent Bacteremia Caused by Methicillin-resistant Staphylococcus aureus Reviewed

Hideharu Hagiya, Shingo Hagioka, Fumio Otsuka

INTERNAL MEDICINE 52 ( 22 ) 2577 - 2582 2013

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN SOC INTERNAL MEDICINE

A 73-year-old man with long-term food deprivation and total parenteral nutrition was diagnosed with septic pulmonary emboli (SPE) and a persistent bacteremia caused by central line-associated blood stream methicillin-resistant Staphylococcus aureus (MRSA) infection. Although daptomycin (DAP) failed to treat the persistent bacteremia, linezolid successfully controlled it. DAP is inactivated by lung surfactant, and therefore, it should not be administered for lower respiratory infections. However, SPE caused by MRSA has been reported to be treatable with DAP since it is an infection of the lung parenchyma. We herein report the lack of effect of daptomycin in SPE treatment.

DOI： 10.2169/internalmedicine.52.0023

Necrotizing Duodenitis Caused by Clostridium perfringens Type A in a Japanese Young Man Reviewed

Hideharu Hagiya, Hiromichi Naito, Junichi Sugiyama, Hiroyoshi Nojima, Shingo Hagioka, Naoki Morimoto

INTERNAL MEDICINE 51 ( 20 ) 2973 - 2976 2012

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN SOC INTERNAL MEDICINE

A 21-year-old Japanese man with a history of marked body weight loss over a short period of time died of necrotizing duodenitis caused by Clostridium perfringens (C. perfringens) type A. C. perfringens type A is considered to usually cause self-limiting gastroenteritis. Necrotizing enteritis sometimes occurs due to C. perfringens in developing countries; however, it is primarily caused by the type C strain and its site of onset is typically the jejunum or ileum. This is a rare case of necrotizing duodenitis caused by C. perfringens type A in a Japanese young man. Physicians need to be more aware of this emerging fatal disease in developed countries.

DOI： 10.2169/internalmedicine.51.8407

Severe Soft Tissue Infection of the Lower Extremity Caused by Haemophilus influenzae (serotype f, biotype II) in an Adult Patient Reviewed

Hideharu Hagiya, Tomoko Murase, Hiromichi Naito, Shingo Hagioka, Naoki Morimoto

INTERNAL MEDICINE 51 ( 13 ) 1783 - 1787 2012

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN SOC INTERNAL MEDICINE

The infection caused by non-b-type Haemophilus influenzae has been increasing in this Hib (H. influenzae serotype b) vaccination era. H. influenzae serotype f (Hif) is considered as one of those emerging pathogens. In general, H. influenzae is a common pathogen of such as pneumonia, otitis media, and meningitis, but is rare in soft tissue infection, especially at the extremity. We report a rare case of severe soft tissue infection caused by Hif which occurred at the lower extremity of immunocompetent adult patient.

DOI： 10.2169/internalmedicine.51.7209

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