研究者詳細 - 田嶋　智之

BNCT pancreatic cancer treatment strategy with glucose-conjugated boron drug. 国際誌

Takuya Fujimoto, Fuminori Teraishi, Noriyuki Kanehira, Tomoyuki Tajima, Yoshinori Sakurai, Natsuko Kondo, Masahiro Yamagami, Atsushi Kuwada, Akira Morihara, Mizuki Kitamatsu, Atsushi Fujimura, Minoru Suzuki, Yutaka Takaguchi, Kunitoshi Shigeyasu, Toshiyoshi Fujiwara, Hiroyuki Michiue

Biomaterials 309 122605 - 122605 2024年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

Multidisciplinary therapy centered on radical surgery for resectable pancreatic cancer is expected to prolong prognosis, but relies on CA19-9 biomarker levels to determine treatment strategy. Boron neutron capture therapy (BNCT) is a chemoradiotherapy using tumor hyperaccumulator boron drugs and neutron irradiation. The purpose of this study is to investigate novel boron drug agents for BNCT for pancreatic cancer. Bioinformatics was used to evaluate the uptake of current boron amino acid (BPA) drugs for BNCT into pancreatic cancer. The expression of the amino acid transporter LAT1, a BPA uptake transporter, was low in pancreatic cancer and even lower in high CA19-9 pancreatic cancer. In contrast, the glucose transporter was high in high CA19-9 pancreatic cancers and inversely correlated with LAT1 expression. Considering the low EPR effect in pancreatic cancer, we synthesized a small molecule Glucose-BSH, which is boron BSH bound to glucose, and confirmed its specific uptake in pancreatic cancer. uptake of Glucose-BSH was confirmed in an environment compatible with the tumor microenvironment. The therapeutic efficacy and safety of Glucose-BSH by therapeutic neutron irradiation were confirmed with BNCT. We report Glucose-BSH boron drug discovery study of a Precision Medicine BNCT with application to high CA19-9 pancreatic cancer.

DOI： 10.1016/j.biomaterials.2024.122605

有機色素内包単層カーボンナノチューブの合成を志向した内包配向基の創製

折田明浩, 高口豊, 田嶋智之, 奥田靖浩

Annual Report of the Okayama Foundation for Science and Technology 96 ( 1 ) 57 - 64 2023年1月

Hot Electron Extraction in SWCNT/TiO2 for Photocatalytic H2 Evolution from Water 国際誌

Masahiro Yamagami, Tomoyuki Tajima, Zihao Zhang, Jun Kano, Ki-ichi Yashima, Takana Matsubayashi, Huyen Khanh Nguyen, Naoto Nishiyama, Tomoya Hayashi, Yutaka Takaguchi

Nanomaterials 12 ( 21 ) 3826 - 3826 2022年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

Single-walled carbon nanotube (SWCNT)/TiO2 hybrids were synthesized using 1,10-bis(decyloxy)decane-core PAMAM dendrimer as a molecular glue. Upon photoirradiation of a water dispersion of SWCNT/TiO2 hybrids with visible light (λ > 422 nm), the hydrogen evolution reaction proceeded at a rate of 0.95 mmol/h·g in the presence of a sacrificial agent (1-benzyl-1,4-dihydronicotinamide, BNAH). External quantum yields (EQYs) of the hydrogen production reaction photosensitized by (6,5), (7,5), and (8,3) tubes were estimated to be 5.5%, 3.6%, and 2.2%, respectively, using monochromatic lights corresponding to their E22 absorptions (570 nm, 650 nm, and 680 nm). This order of EQYs (i.e., (6,5) > (7,5) > (8,3)SWCNTs) exhibited the dependence on the C2 energy level of SWCNT for EQY and proved the hot electron extraction pathway.

DOI： 10.3390/nano12213826

カーボンナノチューブ内外の分子間光電子誘起移動によって促進される色素増感水分解水素生成

水口拓也, 田嶋智之, 山神将大, 高口豊, 高口豊

ホスト-ゲスト・超分子化学シンポジウム講演要旨集 129 ( 1 ) 2021年1月

Photoinduced Electron Transfer in a MoS2/Anthracene Mixed-Dimensional Heterojunction in Aqueous Media

Tomoyuki Tajima, Shogo Okabe, Yutaka Takaguchi

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 93 ( 6 ) 745 - 750 2020年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：CHEMICAL SOC JAPAN

Mixed-dimensional (0D/2D) van der Waals heterojunctions were constructed by physical adsorption of anthracene (Anth) onto few-layer MoS2 nanosheets. The physical modification of few-layer MoS2 nanosheets using anthryl dendron 1, i.e., a poly(amidoamine) dendrimer having an anthracene core, via a simple yet efficient exfoliation approach afforded MoS2/1 hybrids, which are stable for at least one month. The emission quenching typical for anthracene is also observed in the MoS2/anthracene mixed-dimensional heterojunctions. Transient absorption measurements on MoS2/1 hybrids proved that photoinduced electron transfer occurs at the MoS2/anthracene interface. The lifetime of the singlet excited state (tau(S1)((1)Anth*)) for MoS2/1 was evaluated to be 4.1 ns, which is shorter than that of anthryl dendron 1 (13 ns). Interestingly, a remarkably long lifetime was observed for the anthracene cation radical (6.1 mu s). Relatively long lifetimes of charge-separate states of MoS2/1 hybrids would be beneficial design features for efficient photovoltaics, photocatalysts, and related optoelectronic applications.

DOI： 10.1246/bcsj.20200026

Molecular design of benzothiadiazole-based dyes for working with carbon nanotube photocatalysts 査読

Takaguchi Yutaka, Miyake Hideaki, Izawa Takumi, Miyamoto Daiki, Sagawa Ryohei, Tajima Tomoyuki

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS 194 ( 7 ) 707 - 711 2019年7月

Disproportionation-induced solid-state fluorescence in 6,13-dihydropentacenes 査読国際誌

Tajima Tomoyuki, Sanda Rai, Nishihara Katsuya, Shirai Hitoshi, Okuda Yasuhiro, Orita Akihiro, Takaguchi Yutaka

RSC ADVANCES 9 ( 30 ) 17035 - 17039 2019年6月

Carbon-nanotube-based Photocatalysts for Water Splitting in Cooperation with BiVO4 and [Co(bpy)(3)](3+/2+) 査読

Izawa Takumi, Kalousek Vit, Miyamoto Daiki, Murakami Noritake, Miyake Hideaki, Tajima Tomoyuki, Kurashige Wataru, Negishi Yuichi, Ikeue Keita, Ohkubo Takahiro, Takaguchi Yutaka

CHEMISTRY LETTERS 48 ( 5 ) 410 - 413 2019年5月

Physical modification of carbon nanotubes with a dendrimer bearing terminal mercaptoundecahydrododecaborates (Na2B12H11S) 査読

Masahiro Yamagami, Tomoyuki Tajima, Kango Ishimoto, Hideaki Miyake, Hiroyuki Michiue, Yutaka Takaguchi

HETEROATOM CHEMISTRY 29 ( 5-6 ) 2018年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-HINDAWI

The thiol-substituted B-12-cluster mercaptoundecahydro-closo-dodecaborate Na-2[B12H11SH] (BSH) was successfully attached to a poly(amido)amine (PAMAM) dendrimer, which contains a bis(decyloxy)decane core. The physical modification of single-walled carbon nanotubes (SWCNTs) with dendrimer(SB12)(4) afforded a SWCNT/dendrimer(SB12)(4) nanohybrid that exhibited NIR-I-to-NIR-II fluorescence. Herein, we describe a promising strategy for in vivo imaging of boron clusters that may be widely applicable to boron neutron capture therapy.

DOI： 10.1002/hc.21467

Hydrogen-Evolving CNT-Photocatalysts for Effective Use of Solar Energy

Yutaka Takaguchi, Tomoyuki Tajima, Hideaki Miyake

Nanocarbons for Energy Conversion: Supramolecular Approaches 205 - 218 2018年8月

A facile synthesis of a SnO2/Graphene oxide nano-nano composite and its photoreactivity 査読

Tomoyuki Tajima, Haruko Goto, Masayasu Nishi, Takahiro Ohkubo, Yuta Nishina, Hideaki Miyake, Yutaka Takaguchi

Materials Chemistry and Physics 212 149 - 154 2018年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier Ltd

A novel SnO2/graphene oxide (GO) nano-nano composite was prepared by a facile sol–gel process. X-Ray diffraction (XRD), scanning electron microscopy (SEM), Raman spectroscopy, and nitrogen adsorption–desorption isotherms measurements confirmed the formation of a SnO2/GO nano-nano composite. The photoreaction of this SnO2/GO nano-nano composite was studied via the photodegradation of rhodamine B (RhB). Interestingly, the degradation mode of RhB in oxygen-saturated solution is photocatalytic reaction, but the degradation mode in argon-saturated solution is not photocatalytic reaction.

DOI： 10.1016/j.matchemphys.2018.03.046

Scopus

Apatite coating on dendrimer-modified buckypaper and the formation of nanoapatite on MWCNTs 査読

Tomoyuki Tajima, Tomoaki Tanaka, Hideaki Miyake, Ill Yong Kim, Chikara Ohtsuki, Yutaka Takaguchi

Polymer Journal 50 ( 9 ) 1 - 7 2018年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Nature Publishing Group

Multi-walled carbon nanotube (MWCNT)/dendrimer sheet scaffolds, i.e., dendrimers attached to the surface of MWCNT buckypaper, were fabricated, and a hydroxyapatite (HAp) coating prepared on dendrimer-modified buckypaper using an alternate soaking process (ASP) is described. The amount of the HAp that is retained on the surface of the MWCNT/dendrimer sheet scaffolds depends on the modification method
i.e., surface modification performed after the formation of the buckypaper is much more effective in producing MWCNT/HAp hybrid materials than surface modification prior to the formation of the buckypaper. Moreover, biomimetic crystallization of calcium phosphate on buckypaper in simulated body fluid (SBF) was carried out. TEM analysis of the resulting MWCNT/dendrimer sheet scaffolds revealed that the MWCNT backbone was covered with scaly crystals.

DOI： 10.1038/s41428-018-0056-4

Scopus

H2-evolving SWCNT Photocatalyst for Effective Use of Solar Energy 査読

Enhanced Photosensitized Hydrogen Production by Encapsulation of Ferrocenyl Dyes into Single-Walled Carbon Nanotubes 査読国際誌

Noritake Murakami, Hideaki Miyake, Tomoyuki Tajima, Kakeru Nishikawa, Ryutaro Hirayama, Yutaka Takaguchi

Journal of the American Chemical Society 140 ( 11 ) 3821 - 3824 2018年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：American Chemical Society

Dye-encapsulated single-walled carbon nanotubes (SWCNTs) were employed for the construction of a coaxial three-component dye/SWCNT/C60 heterojunction. Despite the larger diameter (∼1.4 nm) of the SWCNTs relative to that set by Flavel's rule (0.95 nm), the photoinduced electron transfer from dye-encapsulated SWCNTs to C60 proceeded smoothly, resulting in the photosensitized evolution of H2 from H2O using a ferrocenyl-based photosensitizer, which was confirmed by the action spectra.

DOI： 10.1021/jacs.7b12845

Photo-induced H2 evolution from water: Via the dissociation of excitons in water-dispersible single-walled carbon nanotube sensitizers 査読国際誌

Kango Ishimoto, Tomoyuki Tajima, Hideaki Miyake, Masahiro Yamagami, Wataru Kurashige, Yuichi Negishi, Yutaka Takaguchi

Chemical Communications 54 ( 4 ) 393 - 396 2018年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Royal Society of Chemistry

To observe a clear-cut example of the formation of mobile carriers from excitons on semiconducting single-walled carbon nanotubes (s-SWCNTs) surrounded by a medium with a high dielectric constant, water-dispersible s-SWCNT nanocomposites were fabricated by physical modifications using poly(amidoamine) dendrimers that contain an aliphatic core. The evolution of H2 from water using these s-SWCNT/dendrimer nanocomposites as photosensitizers under irradiation with visible light demonstrated a photo-induced electron transfer from the s-SWCNTs to the co-catalysts.

DOI： 10.1039/c7cc07194a

Kiki Kurniawan, Noritake Murakami, Yuto Tango, Takumi Izawa, Kakeru Nishikawa, Ken Watanabe, Hideaki Miyake, Tomoyuki Tajima, Yutaka Takaguchi

Proceedings of the Nature Research Society 1 01004 2017年10月

Synthesis and Properties of (Terthiophene)(4)-Poly(amidoamine)-C-60 Pentad 査読

Tomoyuki Tajima, Takuya Nishihama, Shogo Miyake, Nobuhiro Takahashi, Yutaka Takaguchi

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 88 ( 5 ) 736 - 745 2015年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：CHEMICAL SOC JAPAN

(Terthiophene)(4)-poly(amidoamine)-C-60 pentad 8a and (terthiophene)(2)-poly(amidoamine)-C-60 triad 8b have been synthesized with the aim of developing novel precursors for photoinduced polymerization. The electrochemical oxidation of pentad 8a by repetitive cyclic voltammogram scans gave a polymeric 8a film on a FTO electrode, which showed electrochemical activity and photoelectric response. When a monomer film of 8 on FTO was irradiated with visible light, the photoinduced polymerization of the terthiophene moiety was observed. The photoanodic features of an electropolymerized film of 8a on a FTO (poly-8a(electro)/FTO) and 8a/FTO were investigated regarding photocurrent response to light irradiation. The photocurrent of a photopolymerized 8a film on a FTO (poly-8a(photo)/FTO) electrode formed by photoreaction of 8a/FTO, is approximately 6 times greater than that of the 8a/FTO electrode.

DOI： 10.1246/bcsj.20140283

Synthesis and structures of monomeric group 14 triols and their reactivity 査読

Lucian-Cristian Pop, Nobuaki Kurokawa, Hiroaki Ebata, Katsuya Tomizawa, Tomoyuki Tajima, Masatoshi Ikeda, Michikazu Yoshioka, Monique Biesemans, Rudolph Willem, Mao Minoura, Masaichi Saito

CANADIAN JOURNAL OF CHEMISTRY 92 ( 6 ) 542 - 548 2014年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS

The first stable stannanetriol and germanetriol bearing sterically congested aryl groups were synthesized by hydrolysis of the corresponding trichloro-stannane and -germane. The stannanetriol is monomeric in solution as well as in the crystalline state, as evidenced by X-ray diffraction analysis and CP-MAS NMR spectroscopy. The stannanetriol reacted with silicone grease to afford a cagelike compound having three Sn-O-Si-O-Sn linkages in the molecule. All the group 14 triols can be converted to the corresponding trihalo compounds in good yields.

DOI： 10.1139/cjc-2013-0496

A Convenient Route to Synthetic Analogues of the Oxidized Form of High-Potential Iron-Sulfur Proteins 査読国際誌

Kazuki Tanifuji, Norihiro Yamada, Tomoyuki Tajima, Takahiro Sasamori, Norihiro Tokitoh, Tsukasa Matsuo, Kohei Tamao, Yasuhiro Ohki, Kazuyuki Tatsumi

INORGANIC CHEMISTRY 53 ( 8 ) 4000 - 4009 2014年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：AMER CHEMICAL SOC

An amide-bound [Fe4S4](3+). cluster, [Fe4S4{N-(SiMe3)(2)}(4)](-) (1), was found to serve as a convenient precursor for synthetic analogues of the oxidized form of high-potential iron sulfur proteins. Treatment of 1 with 4 equiv of bulky thiols led to replacement of the amide ligands with thiolates, giving rise to a series of [Fe4S4(SR)(4)](-) clusters (R = Dmp (2a), Tbt (2b), Eind (2c), Dxp (2d), Dpp (2e); Dmp = 2,6-di(mesityl)phenyl, Tbt = 2,4,6-tris[bis(trimethylsily)methyl]phenyl, Eind = 1,1,3,3,5,5,7,7-octaethyl-s-hydrindacen-4-yl, Dxp = 2,6-di(m-xylyl)phenyl, Dpp = 2,6-diphenylphenyl). These clusters were characterized by the mass spectrum, the EPR spectrum, and X-ray crystallography. The redox potentials of the [Fe4S4](3+/2+) couple, -0.82 V (2a), -0.86 V (2b), -0.84 V (2c), -0.74 V (2d), and -0.63 V (2e) vs Ag/Ag+ in THF, are significantly more negative than that of [Fe4S4(SPh)(4)](-/2-) (-0.21 V).

DOI： 10.1021/ic402890k

Spectroscopic Characterization of Nanohybrids Consisting of Single-walled Carbon Nanotubes and Fullerodendron 査読

Hironori Suzuki, Yoko Iizumi, Masayoshi Tange, Soon-Kil Joung, Akihiro Furube, Takaaki Wada, Tomoyuki Tajima, Yutaka Takaguchi, Toshiya Okazaki

FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES 22 ( 1-3 ) 75 - 87 2014年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：TAYLOR & FRANCIS INC

Hydrogen gas, which can be used in fuel cells to generate electricity, is considered the ultimate clean energy source. Recently, it was reported that a photo-induced electron transfer system consisting of single-walled carbon nanotubes (SWCNTs) and fullerodendrons shows photo-catalytic activity with a very high quantum yield for splitting water under visible light irradiation. However, the mechanism of high efficiency hydrogen generation is not yet clearly understood. We report here the spectroscopic characterizations of the SWCNT-fullerodendron composites. The results indicate two important fundamental properties of the composite system. First, fullerodendrons preferentially interact with the semiconducting SWCNTs instead of with their metallic counterparts. Second, the photo-induced electron transfer process from the C-60 moiety of fullerodendrons to SWCNTs occurs more efficiently with an increasing tube diameter.

DOI： 10.1080/1536383X.2013.794340