研究者詳細 - 冨樫　庸介

論文 - 冨樫　庸介

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Association of Diffuse, Random Pulmonary Metastases, Including Miliary Metastases, With Epidermal Growth Factor Receptor Mutations in Lung Adenocarcinoma 査読

Yosuke Togashi, Katsuhiro Masago, Takeshi Kubo, Yuichi Sakamori, Young Hak Kim, Yukimasa Hatachi, Akiko Fukuhara, Tadashi Mio, Kaori Togashi, Michiaki Mishima

CANCER 117 ( 4 ) 819 - 825 2011年2月

Clinicopathologic Factors Affecting the Progression-Free Survival of Patients With Advanced Non-Small-Cell Lung Cancer After Gefitinib Therapy 査読

Katsuhiro Masago, Shiro Fujita, Yosuke Togashi, Young Hak Kim, Yukimasa Hatachi, Akiko Fukuhara, Hiroki Nagai, Yuichi Sakamori, Tadashi Mio, Michiaki Mishima

CLINICAL LUNG CANCER 12 ( 1 ) 56 - 61 2011年1月

Infectious background of febrile advanced lung cancer patients who received chemotherapy 査読

Katsuhiro Masago, Akiko Fukuhara, Yutaka Ito, Yukimasa Hatachi, Kaoru Irisa, Yuichi Sakamori, Yosuke Togashi, Shiro Fujita, Young Hak Kim, Tadashi Mio, Michiaki Mishima

ONCOLOGY LETTERS 1 ( 5 ) 849 - 853 2010年9月

Octreotide, a Somatostatin Analogue, in the Treatment of Chylothorax Associated with Idiopathic Fibrosing Mediastinitis 査読

Yosuke Togashi, Young Hak Kim, Ryo Miyahara, Kaoru Irisa, Yuichi Sakamori, Katsuhiro Masago, Tadashi Mio, Hiroshi Date, Michiaki Mishima

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 222 ( 1 ) 51 - 53 2010年9月

Cerebrospinal Fluid Concentration of Erlotinib and its Active Metabolite OSI-420 in Patients with Central Nervous System Metastases of Non-small Cell Lung Cancer 査読

Yosuke Togashi, Katsuhiro Masago, Masahide Fukudo, Tomohiro Terada, Shiro Fujita, Kaoru Irisa, Yuichi Sakamori, Young Hak Kim, Tadashi Mio, Ken-ichi Inui, Michiaki Mishima

JOURNAL OF THORACIC ONCOLOGY 5 ( 7 ) 950 - 955 2010年7月

A Case of Radiation Recall Pneumonitis Induced by Erlotinib, Which Can be Related to High Plasma Concentration 査読

Yosuke Togashi, Katsuhiro Masago, Michiaki Mishima, Masahide Fukudo, Ken-ichi Inui

JOURNAL OF THORACIC ONCOLOGY 5 ( 6 ) 924 - 925 2010年6月

Pharmacokinetics of Erlotinib and Its Active Metabolite OSI-420 in Patients with Non-small Cell Lung Cancer and Chronic Renal Failure Who Are Undergoing Hemodialysis 査読

Yosuke Togashi, Katsuhiro Masago, Masahide Fukudo, Tomohiro Terada, Yasuaki Ikemi, Young Hak Kim, Shiro Fujita, Kaoru Irisa, Yuichi Sakamori, Tadashi Mio, Ken-ichi Inui, Michiaki Mishima

JOURNAL OF THORACIC ONCOLOGY 5 ( 5 ) 601 - 605 2010年5月

Good Clinical Response to Erlotinib in a Non-Small Cell Lung Cancer Patient Harboring Multiple Brain Metastases and a Double Active Somatic Epidermal Growth Factor Gene Mutation. 査読国際誌

Katsuhiro Masago, Yosuke Togashi, Masahide Fukudo, Tomohiro Terada, Kaoru Irisa, Yuichi Sakamori, Shiro Fujita, Young Hak Kim, Tadashi Mio, Ken-Ichi Inui, Michiaki Mishima

Case reports in oncology 3 ( 2 ) 98 - 105 2010年4月

記述言語：英語

Recently, 2 small molecule kinase inhibitors (TKIs), targeting epidermal growth factor receptor (EGFR), have proven effective in the treatment of non-small cell lung cancer. However, it is unknown whether the EGFR double activating mutation of L858R in exon 21 and the in-frame deletion in exon 19 is a predictor of the effectiveness of EGFR-TKIs. We report for the first time a case of non-small cell lung cancer with central nervous system metastases harboring a rare EGFR double activating mutation who showed a good clinical response to erlotinib, regardless of his poor performance status, as swallowing is not possible. Therefore, we suggest that erlotinib may become a therapeutic choice in cases of central nervous system metastases even with poor performance status.

DOI： 10.1159/000310830

PubMed

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Outcome of Surgical Treatment for Metastatic Vertebra Bone Tumor in Advanced Lung Cancer. 査読国際誌

Akiko Fukuhara, Katsuhiro Masago, Masashi Neo, Shunsuke Fujibayashi, Shiro Fujita, Yukimasa Hatachi, Kaoru Irisa, Yuichi Sakamori, Yosuke Togashi, Young Hak Kim, Tadashi Mio, Michiaki Mishima

Case reports in oncology 3 ( 1 ) 63 - 71 2010年3月

記述言語：英語

BACKGROUND: Spinal metastases of patients with advanced stage lung cancer are an important target for palliative therapy, because their incidence is high, and they often cause severe symptoms and worsen the quality of life. Surgery is one of the most effective treatment options, but the indication of surgery is unclear as the procedure is invasive and patients with spinal metastasis have a rather short life expectancy. Furthermore, there have been few studies that have focused on lung cancer with poor prognosis. METHODS: We reviewed all of the cases of lung cancer from January 1999 to July 2007 in the Department of Respiratory Medicine, Kyoto University Hospital, Japan. Thirteen patients with metastatic spinal tumor of lung cancer underwent surgery, and all of them had a poor performance status score (3 or 4). RESULTS: Neurological improvement by at least 1 Frankel grade was seen in 10 of 14 cases (71%). Improvement of the movement capacity was noted in 9 of 14 cases (64%), and pain improvement was noted in 12 of 14 (86%). Median postoperative survival was 5 months (1-25 months). In particular, the group with a good postoperative performance status score (0-2) was shown to have a better median postoperative survival of 13 months. CONCLUSIONS: Surgical treatment for symptomatic metastatic spinal tumor of lung cancer can improve quality of life in a substantially high percentage of patients. Surgery should be considered even if preoperative performance status is poor.

DOI： 10.1159/000299385

PubMed

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Clinical Significance of Pretreatment C-Reactive Protein in Patients with Advanced Nonsquamous, Non-Small Cell Lung Cancer Who Received Gefitinib 査読

Katsuhiro Masago, Shiro Fujita, Yosuke Togashi, Young Hak Kim, Yukimasa Hatachi, Akiko Fukuhara, Hiroki Nagai, Kaoru Irisa, Yuichi Sakamori, Chiyuki Okuda, Tadashi Mio, Michiaki Mishima

ONCOLOGY 79 ( 5-6 ) 355 - 362 2010年

急性骨髄性白血病を発症したLoeys-Dietz症候群査読

冨樫庸介, 迫田寛人, 菅原浩之, 浅越康助, 松澤佑次

臨床血液 49 ( 8 ) 664 - 667 2008年8月

大動脈瘤に起因する慢性播種性血管内凝固症候群を呈した家族性高コレステロール血症の1例

冨樫庸介, 菅原浩之, 平岡久豊, 松澤佑次

住友病院医学雑誌 ( 35 ) 45 - 50 2008年7月

A Japanese family of typical loeys-dietz syndrome with a TGFBR2 mutation 査読

Yosuke Togashi, Hiroto Sakoda, Akira Nishimura, Naomichi Matsumoto, Hisatoyo Hiraoka, Yuji Matsuzawa

INTERNAL MEDICINE 46 ( 24 ) 1995 - 2000 2007年

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