2022/07/02 更新

写真a

オオツカ フミオ
大塚 文男
OTSUKA Fumio
所属
医歯薬学域 教授
職名
教授
外部リンク

学位

  • 医学博士 ( 岡山大学 )

研究キーワード

  • 内科学

  • 総合診療学

  • 内分泌学

  • 内科学

  • 総合診療学

研究分野

  • ライフサイエンス / 代謝、内分泌学

学歴

  • 岡山大学    

    - 1998年

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    国名: 日本国

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  • 岡山大学   Graduate School, Division of Medicine   Endocrinology

    - 1998年

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  • 岡山大学   Medical School  

    - 1992年

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    国名: 日本国

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  • 岡山大学   Faculty of Medicine  

    - 1992年

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経歴

  • 岡山大学大学院医歯薬学総合研究科   総合内科学   教授

    2012年 - 現在

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  • 岡山大学病院   内分泌センター   准教授

    2009年 - 2012年

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  • 岡山大学医歯薬学総合研究科   助教

    2007年 - 2009年

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  • 岡山大学医歯薬学総合研究科   助手

    2005年 - 2007年

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  • 岡山大学   Okayama University Hospital   職員(医療系)

    2003年 - 2005年

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  • 米国カルフォルニア大学サンディエゴ校 研究員

    1999年 - 2002年

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  • 岡山大学   Okayama University Hospital

    1998年 - 1999年

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  • Medical Staff,University Hospital of Medicine and Dentistry,Okayama University

    1998年 - 1999年

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  • Medical Staff

    1992年 - 1994年

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  • 呉共済病院 職員(医療系)

    1992年 - 1994年

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所属学協会

  • 日本ステロイドホルモン学会

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  • 欧州内分泌学会

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  • 日本生殖内分泌学会

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  • 日本神経内分泌学会

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  • 日本人類遺伝学会

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  • 日本病院総合診療医学会

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  • 日本心血管内分泌代謝学会

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  • 日本リウマチ学会

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  • 日本内分泌学会

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  • 米国内分泌学会

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  • 日本内科学会

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  • 日本甲状腺学会

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  • 日本下垂体研究会

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  • 日本プライマリ・ケア連合学会

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  • 日本間脳下垂体腫瘍学会

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  • 日本プライマリ・ケア連合学会

  • 日本下垂体研究会

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委員歴

  • 日本内分泌学会 中国支部副支部長  

    2020年 - 現在   

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    団体区分:学協会

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  • 日本下垂体研究会 評議員  

    2019年 - 現在   

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    団体区分:学協会

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  • 日本医療安全調査機構調査支援医(中国四国ブロック)  

    2018年 - 現在   

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    団体区分:学協会

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  • 日本ステロイドホルモン学会 理事  

    2016年 - 現在   

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    団体区分:学協会

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  • 日本内分泌学会 保険委員会委員  

    2015年 - 現在   

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    団体区分:学協会

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  • 日本間脳下垂体腫瘍学会 理事  

    2015年 - 現在   

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    団体区分:学協会

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  • 日本病院総合診療医学会 評議員・理事  

    2014年 - 現在   

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    団体区分:学協会

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  • 日本神経内分泌学会 評議員・理事  

    2014年 - 現在   

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    団体区分:学協会

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  • 日本生殖内分泌学会 評議員・理事  

    2013年 - 現在   

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    団体区分:学協会

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  • 日本内科学会 評議員  

    2013年 - 現在   

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    団体区分:学協会

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  • 日本内分泌学会 若手臨床内分泌医育成委員会委員  

    2011年 - 現在   

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    団体区分:学協会

    日本内分泌学会

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  • 日本内分泌学会 中国支部内分泌疾患コンサルタント委員会委員長  

    2010年 - 現在   

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    団体区分:学協会

    日本内分泌学会

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  • 成人成長ホルモン分泌不全症地区委員  

    2010年 - 現在   

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    団体区分:学協会

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  • 日本医療安全調査機構 診療行為に関連した死亡の調査 分析モデル事業 解剖立ち会い臨床医 (2010-)  

    2010年   

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  • 岡山県難病対策協議会 特定疾患認定審査部会  

    2009年 - 現在   

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    団体区分:自治体

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  • 日本内科学会 中国支部評議員  

    2008年 - 現在   

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    団体区分:学協会

    日本内科学会

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  • 日本内分泌学会 中国支部幹事  

    2008年 - 現在   

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    団体区分:学協会

    日本内分泌学会

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  • 日本内分泌学会 評議員  

    2007年 - 現在   

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    団体区分:学協会

    日本内分泌学会

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  • 日本内分泌学会   教育責任者  

    2006年 - 現在   

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    団体区分:学協会

    日本内分泌学会

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  • 日本内分泌学会 代議員  

    2005年 - 現在   

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    団体区分:学協会

    日本内分泌学会

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論文

  • Global public awareness of Castleman disease and TAFRO syndrome between 2015 and 2021: A Google Trends analysis

    Yoshito Nishimura, Midori Filiz Nishimura, David C. Fajgenbaum, Frits van Rhee, Yasuharu Sato, Fumio Otsuka

    eJHaem   2022年4月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1002/jha2.459

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    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jha2.459

  • Relationship between patients’ characteristics and efficacy of calcimimetics for primary hyperparathyroidism in the elderly

    Koichiro Yamamoto, Yasuhiro Nakano, Kazuki Tokumasu, Hiroyuki Honda, Kou Hasegawa, Asuka Sato, Hiroko Ogawa, Mikako Obika, Yoshihisa Hanayama, Fumio Otsuka

    Clinical Case Reports   10 ( 4 )   2022年4月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1002/ccr3.5713

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    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ccr3.5713

  • Low hematocrit reduces the efficiency of <scp>CD34</scp> + cell collection when using the Spectra Optia continuous mononuclear cell collection procedure

    Takumi Kondo, Nobuharu Fujii, Keiko Fujii, Yuichi Sumii, Tomohiro Urata, Maiko Kimura, Masayuki Matsuda, Shuntaro Ikegawa, Kana Washio, Hideaki Fujiwara, Noboru Asada, Daisuke Ennishi, Hisakazu Nishimori, Ken‐ichi Matsuoka, Fumio Otsuka, Yoshinobu Maeda

    Transfusion   2022年3月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Wiley  

    DOI: 10.1111/trf.16856

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    その他リンク: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/trf.16856

  • Hemothorax and Bloody Ascites Caused by Vascular Ehlers-Danlos Syndrome. 国際誌

    Shuichi Tanaka, Hiroyuki Honda, Kou Hasegawa, Koji Tomita, Reimi Sogawa, Hideki Yamamoto, Takao Hiraki, Akira Hirasawa, Fumio Otsuka

    The American journal of medicine   2022年3月

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  • Idiopathic multicentric Castleman disease with positive antiphospholipid antibody: atypical and undiagnosed autoimmune disease?

    Yoshito Nishimura, Asami Nishikori, Haruki Sawada, Torrey Czech, Yuki Otsuka, Midori Filiz Nishimura, Hiroki Mizuno, Naoki Sawa, Shuji Momose, Kumiko Ohsawa, Fumio Otsuka, Yasuharu Sato

    Journal of clinical and experimental hematopathology : JCEH   2022年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Idiopathic multicentric Castleman disease (iMCD) is a systemic disorder characterized by systemic inflammation and organ dysfunction associated with an increase in pro-inflammatory cytokines. Some patients with iMCD are positive for autoantibodies, although their significance and relationship with specific associated autoimmune diseases are unclear. This study retrospectively analyzed the clinicopathological features of iMCD patients focusing on autoantibodies. Among 63 iMCD patients in our database, 19 were positive for at least one autoantibody. Among the 19, we identified five with plasma cell type (PC)-iMCD lymph node histopathology and positive anti-phospholipid antibodies. These patients were likely to have thrombocytopenia, anasarca, fever, reticulin fibrosis or renal insufficiency, organomegaly (TAFRO) symptoms, and thrombotic events. The present study suggests that patients with undiagnosed or atypical autoimmune diseases, including anti-phospholipid syndrome (APS), were treated for iMCD. APS may present with thrombocytopenia or even multi-organ failure, which overlap with clinical presentations of iMCD. Due to differences in the treatment regimen and follow-up, recognition of the undiagnosed autoimmune disease process in those suspected of iMCD is essential. Our study highlights the importance of complete exclusion of differential diagnoses in patients with iMCD in their diagnostic workup.

    DOI: 10.3960/jslrt.21038

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  • Clinical Utility of 4C Mortality Scores among Japanese COVID-19 Patients: A Multicenter Study. 国際誌

    Kazuki Ocho, Hideharu Hagiya, Kou Hasegawa, Kouji Fujita, Fumio Otsuka

    Journal of clinical medicine   11 ( 3 )   2022年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: We analyzed data from COVID-19 patients in Japan to assess the utility of the 4C mortality score as compared with conventional scorings. METHODS: In this multicenter study, COVID-19 patients hospitalized between March 2020 and June 2021, over 16 years old, were recruited. The superiority for correctly predicting mortality and severity by applying the receiver operating characteristic (ROC) curve was compared. A Cox regression model was used to compare the length of hospitalization for each risk group of 4C mortality score. RESULTS: Among 206 patients, 21 patients died. The area under the curve (AUC) (95% confidential interval (CI)) of the ROC curve for mortality and severity, respectively, of 4C mortality scores (0.84 (95% CI 0.76-0.92) and 0.85 (95% CI 0.80-0.91)) were higher than those of qSOFA (0.66 (95% CI 0.53-0.78) and 0.67 (95% CI 0.59-0.75)), SOFA (0.70 (95% CI 0.55-0.84) and 0.81 (95% CI 0.74-0.89)), A-DROP (0.78 (95% CI 0.69-0.88) and 0.81 (95% CI 0.74-0.88)), and CURB-65 (0.82 (95% CI 0.74-0.90) and 0.82 (95% CI 0.76-0.88)). For length of hospitalization among survivors, the intermediate- and high- or very high-risk groups had significantly lower hazard ratios, i.e., 0.48 (95% CI 0.30-0.76)) and 0.23 (95% CI 0.13-0.43) for discharge. CONCLUSIONS: The 4C mortality score is better for estimating mortality and severity in COVID-19 Japanese patients than other scoring systems.

    DOI: 10.3390/jcm11030821

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  • Threat of Staphylococcus aureus Pneumonia in Severe COVID-19 Patients. 国際誌

    Shuichi Tanaka, Koichiro Yamamoto, Hideharu Hagiya, Kou Hasegawa, Fumio Otsuka

    Cureus   14 ( 2 )   e22486   2022年2月

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    記述言語:英語  

    Coronavirus disease 2019 (COVID-19) has been spreading worldwide with unprecedented rapidity. Staphylococcus aureus is reported to frequently cause bacterial complications in patients with COVID-19. We herein present two additional cases of S. aureus pneumonia involving such patients. The first case was an obese 48-year-old man without any particular underlying diseases. The second case was another patient, a 72-year-old man, with hypertension, dyslipidemia, and steatohepatitis. Both patients developed methicillin-susceptible S. aureus pneumonia in the clinical course of COVID-19, to which antibiotic therapy with cefazolin was effectively administered. Through these cases, we emphasize that S. aureus secondary infections should be well cared with a high degree of caution in a case of critically ill COVID-19 patients.

    DOI: 10.7759/cureus.22486

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  • Aging-related Characteristics of Subclinical Hypothyroidism Detected in General Practice.

    Masao Takami, Koichiro Yamamoto, Yoshihisa Hanayama, Yasuhiro Nakano, Kou Hasegawa, Mikako Obika, Hideharu Hagiya, Masanori Furukawa, Fumio Otsuka

    Acta medica Okayama   76 ( 1 )   7 - 15   2022年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Subclinical hypothyroidism (SCH) is diagnosed when serum thyrotropin (TSH) is elevated despite a normal thyroxine level and is known to increase the risk of metabolic disorders. This study was conducted to identify potential laboratory markers suspicious for latent SCH. We retrospectively reviewed 958 outpatients in whom thyroid functions had been examined. Eighty-five (9.1%) of the 939 analyzed subjects had SCH (73% females). In the SCH group, median serum TSH and FT4 levels were 5.04 μU/ml and 1.19 ng/dl, respectively, and auto-thyroid antibodies were detected in 53.8% of patients. SCH group patients were significantly older than patients in the euthyroid group, while there was no intergroup difference in BMI. However, 56.5% of the SCH patients were asymptomatic. In the SCH group, serum aspartate aminotransferase and low-density lipoprotein cholesterol (LDL-C) levels were significantly higher, and the estimated glomerular filtration rate (eGFR) was significantly lower than in the euthyroid group. Among patients less than 65 years of age, SCH patients tended to have lower eGFR and higher LDL-C than euthyroid patients. Age-dependent reductions of red blood cells and serum albumin were more prominent in the SCH than the euthyroid group. Biochemical changes with aging are useful as potential clues for suspecting latent SCH.

    DOI: 10.18926/AMO/63203

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  • Comment on: Short versus prolonged courses of antimicrobial therapy for patients with uncomplicated Pseudomonas aeruginosa bloodstream infection: a retrospective study. 国際誌

    Hideharu Hagiya, Fumio Otsuka

    The Journal of antimicrobial chemotherapy   2021年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/jac/dkab464

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  • Adult Hypogonadism Due to Testicular Adrenal Rest Tumors.

    Koichiro Yamamoto, Kosuke Oka, Kou Hasegawa, Fumio Otsuka

    Internal medicine (Tokyo, Japan)   60 ( 23 )   3839 - 3840   2021年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    DOI: 10.2169/internalmedicine.6501-20

    Web of Science

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  • 総合診療における甲状腺機能低下状態の潜在とその特徴

    高見 優男, 山本 紘一郎, 花山 宜久, 中野 靖浩, 長谷川 功, 小比賀 美香子, 萩谷 英大, 大塚 文男

    日本内分泌学会雑誌   97 ( 4 )   961 - 961   2021年12月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • GH補充療法により脂肪肝の著明な改善を認めたAGHDの1例

    高瀬 了輔, 中野 靖浩, 山本 紘一郎, 越智 可奈子, 本多 寛之, 長谷川 功, 三好 智子, 小川 弘子, 大塚 文男

    日本内分泌学会雑誌   97 ( 4 )   951 - 951   2021年12月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • MEN1疑いの家族歴と上縦隔に進展する副甲状腺癌を認めた1例

    大塚 勇輝, 長谷川 功, 原田 洸, 西村 義人, 岡 浩介, 小野 早和子, 枝園 忠彦, 平沢 晃, 大塚 文男

    日本内分泌学会雑誌   97 ( 4 )   946 - 946   2021年12月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 肺癌治療中の発熱を契機に発見されたペムブロリズマブによるirAEの1例

    平仲 凪, 山本 紘一郎, 田中 秀一, 孫 麗那, 高橋 美砂, 本多 寛之, 長谷川 功, 大塚 文男

    日本内分泌学会雑誌   97 ( 4 )   951 - 951   2021年12月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • COVID-19後の倦怠感を契機に発見されたLOH症候群の1例

    副島 佳晃, 中野 靖浩, 中本 健太, 大塚 勇輝, 櫻田 泰江, 徳増 一樹, 本多 寛之, 長谷川 功, 萩谷 英大, 大塚 文男

    日本内分泌学会雑誌   97 ( 4 )   958 - 958   2021年12月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • Roles of NR5A1 and NR5A2 in the regulation of steroidogenesis by Clock gene and bone morphogenetic proteins by human granulosa cells.

    Atsuhito Suyama, Nahoko Iwata, Yoshiaki Soejima, Yasuhiro Nakano, Koichiro Yamamoto, Takahiro Nada, Fumio Otsuka

    Endocrine journal   68 ( 11 )   1283 - 1291   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN ENDOCRINE SOC  

    The functional role of the transcription factors NR5A1 and NR5A2 and their interaction with Clock gene and bone morphogenetic proteins (BMPs) were investigated in human granulosa KGN cells. Treatment with BMP-15 and GDF-9 suppressed forskolin (FSK)-induced steroidogenesis as shown by the mRNA expression levels of StAR and P450scc but not the mRNA expression level of P450arom. Of interest, treatment with BMP-15 and GDF-9 also suppressed FSK-induced NR5A2 mRNA expression. Treatment with BMP-15 suppressed NR5A2 mRNA and protein expression but increased Clock mRNA and protein expression levels by granulosa cells. The mRNA expression levels of NR5A1, but not those of NR5A2, were positively correlated with the levels of Clock mRNA, while the mRNA levels of Id-1, the target gene of BMP signaling, were positively correlated with those of NR5A1 but not with those of NR5A2. It was also demonstrated that the mRNA expression levels of NR5A1 were positively correlated with those of P450arom and 3βHSD, whereas the mRNA expression level of NR5A2 was correlated with those of StAR and P450scc. Furthermore, inhibition of Clock gene expression by siRNA attenuated the expression of NR5A1, and the mRNA levels of Clock gene were significantly correlated with those of NR5A1. Collectively, the results suggested a novel mechanism by which Clock gene expression induced by BMP-15 is functionally linked to the expression of NR5A1, whereas NR5A2 expression is suppressed by BMP-15 in granulosa cells. The interaction between Clock NR5A1/NR5A2 and BMP-15 is likely to be involved in the fine-tuning of steroidogenesis by ovarian granulosa cells.

    DOI: 10.1507/endocrj.EJ21-0223

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  • Burnout of Healthcare Workers Amid the COVID-19 Pandemic: A Follow-Up Study. 国際誌

    Yoshito Nishimura, Tomoko Miyoshi, Asuka Sato, Kou Hasegawa, Hideharu Hagiya, Yoshinori Kosaki, Fumio Otsuka

    International journal of environmental research and public health   18 ( 21 )   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI  

    The coronavirus disease 2019 (COVID-19) pandemic has posed a significant challenge to the modern healthcare system and led to increased burnout among healthcare workers (HCWs). We previously reported that HCWs who engaged in COVID-19 patient care had a significantly higher prevalence of burnout (50.0%) than those who did not in November 2020 (period 1). We performed follow-up surveys in HCWs in a Japanese national university hospital, including basic demographics, whether a participant engaged in care of COVID-19 patients in the past 2 weeks, and the Maslach Burnout Inventory in February 2021 (period 2) and May 2021 (period 3). Periods 1 and 3 were amid the surges of COVID-19 cases, and period 2 was a post-surge period with a comparatively small number of COVID-19 patients requiring hospitalization. Response rates to the surveys were 33/130 (25.4%) in period 1, 36/130 (27.7%) in period 2, and 56/162 (34.6%) in period 3, respectively. While no consistent tendency in the prevalence of burnout based on variables was observed throughout the periods, the prevalence of burnout tends to be higher in periods 1 and 3 in those who engaged in COVID-19 patient care in the last 2 weeks (50.0%, 30.8%, 43.1% in period 1, 2, and 3, respectively). Given the prolonged pandemic causing stigmatization and hatred against HCWs leading to increased prevalence of burnout, high-level interventions and supports are warranted.

    DOI: 10.3390/ijerph182111581

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  • Clinical utility of urinary levels of catecholamines and their fraction ratios related to heart rate and thyroid function.

    Naruhiko Sunada, Yoshihisa Hanayama, Koichiro Yamamoto, Yasuhiro Nakano, Takahiro Nada, Hiroyuki Honda, Kou Hasegawa, Hideharu Hagiya, Fumio Otsuka

    Endocrine journal   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Urinary catecholamines (CAs) have been examined for the screening of pheochromocytomas. The decision to perform screening is based on symptoms suggesting secondary hypertension or hyperactivities of the sympathetic nervous system. To elucidate the usefulness of urinary fractions and ratios of CAs, 79 patients in whom 24-h excretions of urinary CAs including adrenaline (AD), noradrenaline (NA) and dopamine (DA) had been examined from 2015 until 2020 were retrospectively analyzed. There were no significant differences in urinary CA levels between two age groups, gender groups and two BMI groups. Patients with histories of preexisting hypertension and diabetes showed significantly higher levels of urinary NA excretion, and the urinary ratio of NA/DA was also increased in the patients with a history of hypertension. Heart rate (HR) was significantly correlated with the urinary ratio of NA/DA. Serum free thyroxine (FT4) concentration and ratio of FT4/thyrotropin (TSH) were correlated with the level of urinary AD. The levels of TSH and FT4/TSH showed negative and positive correlations, respectively, with the urinary NA/DA ratio. Thus, increases of HR are related to the enhanced conversion of DA to NA and increased thyroid hormones are involved in the increase in urinary AD and the conversion of DA to NA. History of lifestyle-related diseases and changes of HR and thyroid functions need to be considered for the evaluation of urinary CAs and their ratios.

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  • 新型コロナウイルス感染症対策における慰労金交付事業の影響およびその評価

    萩谷 英大, 三好 智子, 西村 義人, 徳増 一樹, 本多 寛之, 長谷川 功, 小比賀 美香子, 頼藤 貴志, 大塚 文男

    日本病院総合診療医学会雑誌   17 ( 6 )   608 - 616   2021年11月

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    記述言語:日本語   出版者・発行元:(一社)日本病院総合診療医学会  

    新型コロナウイルス感染症対策の一環として,「新型コロナウイルス感染症対応従事者慰労金交付事業」が実施されたが,その影響・有効性に関するデータは乏しい。2021年4月26日〜5月31日に,岡山県・香川県・広島県の医療機関に勤務する職員を対象にウェブ・アンケートによる横断調査を実施した。1001名からの回答において,慰労金受給率は95.8%であり,59.5%は本事業に満足したと回答した。職種別満足度は,医師(60.8%),メディカルスタッフ(63.9%)に比べて看護職(46.3%)で低かった(p<0.001)。医療機関内職員のみならず,救急隊員,保健所職員,高齢者介護施設の職員も慰労金が支払われるべき業種として高率に理解を得た。慰労金交付事業は,医療従事者等の外的モチベーションとして概ね機能したと考えられるが,給付金額や対象者の選定に関しては検討の余地がある。(著者抄録)

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  • Subcutaneous edema as rare complication of abdominal paracentesis. 国際誌

    Yuki Otsuka, Hirokazu Nagaoka, Yasuhiro Nakano, Hiroyuki Sakae, Kou Hasegawa, Fumio Otsuka

    Clinical case reports   9 ( 11 )   e05116   2021年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Although ascites leakage to the skin is the most frequent complication after abdominal paracentesis, leakage to the subcutaneous space has not been reported. Here, we report a subcutaneous effusion after paracentesis suggesting ascites leakage. We should be aware of this rare complication due to the potential risk of dissemination.

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  • Impact of the world hand hygiene and global handwashing days on public awareness between 2016 and 2020: Google trends analysis. 国際誌

    Yoshito Nishimura, Hideharu Hagiya, Koichi Keitoku, Toshihiro Koyama, Fumio Otsuka

    American journal of infection control   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Scientific evidence suggest that hand hygiene as one of the most effective measures to control infection. To promote good hand hygiene practices, the World Health Organization introduced May 5 as World Hand Hygiene Day (WHHD), and international stakeholders established Global Handwashing Day (GHD) on October 15. However, its contributions to raising public awareness of hand hygiene is unclear. METHODS: This study evaluates the impact of the WHHD and GHD on the public awareness of hand hygiene in Japan, the United Kingdom, the United States, and worldwide from 2016 to 2020, using the relative search volume of "Hand hygiene" in Google Trends as a surrogate. To identify a statistically significant timepoint of a trend change, we performed Joinpoint regression analysis. RESULTS: Upticks of the relative search volumes as well as joinpoints were noted worldwide around the WHHD and GHD from 2016 to 2019, but no joinpoints were identified around the WHHD and GHD in 2020. No such changes were observed in Japan, the United Kingdom, and the United States during these periods. CONCLUSIONS: While the WHHD was originally established to raise awareness of hand hygiene in healthcare facilities, our result suggests that the WHHD and GHD may not have effectively disseminated the importance of hand hygiene to the general public at a country level. Additional policy measures to advocate hand hygiene to the public are necessary to communicate its benefits.

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  • Temporal artery thickening in giant cell arteritis. 国際誌

    Hiromi Ihoriya, Yasuhiro Nakano, Fumio Otsuka

    BMJ case reports   14 ( 10 )   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMJ PUBLISHING GROUP  

    DOI: 10.1136/bcr-2021-247123

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  • Radiologic features of Erdheim-Chester disease. 国際誌

    Koichiro Yamamoto, Yasuhiro Nakano, Kou Hasegawa, Fumio Otsuka

    Rheumatology (Oxford, England)   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/rheumatology/keab799

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  • Idiopathic combined adrenocorticotropin and growth hormone deficiency mimicking chronic fatigue syndrome. 国際誌

    Kazuki Tokumasu, Kanako Ochi, Fumio Otsuka

    BMJ case reports   14 ( 10 )   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMJ PUBLISHING GROUP  

    A 42-year-old man who had suffered from severe fatigue for 5 years was diagnosed as having chronic fatigue syndrome (CFS) and fibromyalgia. Endocrinological workup using combined anterior pituitary function tests showed that the patient had adrenocorticotropin hormone (ACTH) deficiency, with a normal pituitary MRI. Treatment with a physiologic dose of oral hydrocortisone replacement physically ameliorated his general fatigue. A secondary workup using a growth hormone-releasing peptide-2 test revealed that he also had growth hormone (GH) deficiency, and GH replacement therapy was started. His muscle pain and depression were improved by the therapy. Here, we present a rare case of combined deficiency of ACTH and GH in a middle-aged man with severe general fatigue. This case report aims to raise awareness of combined deficiency of ACTH and GH as a differential diagnosis of CFS and its mimics.

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  • Detection of in-frame mutation by IS30-family insertion sequence in the phospholipid phosphatidylglycerol synthase gene (pgsA2) of high-level daptomycin-resistant Corynebacterium striatum. 国際誌

    Kazuyoshi Gotoh, I Putu Bayu Mayura, Yusaku Enomoto, Koji Iio, Osamu Matsushita, Fumio Otsuka, Hideharu Hagiya

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    The emergence of high-level daptomycin (DAP)-resistant (HLDR) Corynebacterium striatum has been reported as a result of loss-of-function point mutations or premature stop codon mutations in a responsible gene, pgsA2. We herein describe the novel detection of an HLDR C. striatum clinical isolate, in which IS30-insertion was corroborated to cause destruction of pgsA2 gene. We isolated an HLDR C. striatum from a critically ill patient with underlying mycosis fungoides who had been treated with DAP for 10 days. With a sequence investigation, IS30-insertion was discovered to split pgsA2 in the HLDR C. striatum strain, which may cause disrupted phospholipid phosphatidylglycerol (PG) production. Future studies should survey the prevalence of IS-mediated gene inactivation among HLDR C. striatum clinical isolates.

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  • Impact of the day of the week on the discontinuation of broad-spectrum antibiotic prescriptions; a multi-centered observational study. 国際誌

    Hiroyuki Honda, Hideharu Hagiya, Tsukasa Higashionna, Yuto Haruki, Mai Haruki, Shiho Kajita, Kengo Mukuda, Yuji Yokoyama, Yasuhiro Nakano, Hiroko Ogawa, Yasuyo Morimoto, Yoshihisa Hanayama, Setsuko Kanda, Hitomi Kataoka, Hitomi Muguruma, Fumio Otsuka

    Scientific reports   11 ( 1 )   20784 - 20784   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATURE PORTFOLIO  

    To encourage and guide antimicrobial stewardship team (AST) activity and promote appropriate antibiotic use, we studied the impact of day of the week on the initiation and discontinuation of antibiotic administration. This was a multicenter observational study conducted at 8 Japanese hospitals from April 1 to September 30, 2019, targeting patients who underwent treatment with broad-spectrum antibiotics, such as anti-methicillin-resistant Staphylococcus aureus agents and anti-pseudomonal agents. We compared the weekly numbers of initiations and discontinuations of antibiotic prescription on each day of the week or on the days after a holiday. There was no statistical difference in the number of antibiotic initiations on both weekdays and the day after a holiday. However, antibiotic discontinuation was significantly higher from Tuesday onward than Monday and from the second day than the first day after a holiday. Similar trends were observed regardless of the categories of antibiotics, hospital and admission ward, and AST activity. This study suggests that broad-spectrum antibiotics tend to be continued during weekends and holidays and are most likely to be discontinued on Tuesday or the second day after a holiday. This was probably due to behavioral factors beyond medical indications, requiring further antimicrobial stewardship efforts in the future.

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  • Biphasic Roles of Clock Genes and Bone Morphogenetic Proteins in Gonadotropin Expression by Mouse Gonadotrope Cells. 国際誌

    Yoshiaki Soejima, Nahoko Iwata, Yasuhiro Nakano, Koichiro Yamamoto, Atsuhito Suyama, Takahiro Nada, Fumio Otsuka

    International journal of molecular sciences   22 ( 20 )   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI  

    Roles of Clock genes and the bone morphogenetic protein (BMP) system in the regulation of gonadotropin secretion by gonadotropin-releasing hormone (GnRH) were investigated using mouse gonadotropin LβT2 cells. It was found that luteinizing hormone (LH)β mRNA expression level in LβT2 cells changed gradually over time, with LHβ expression being suppressed in the early phase up to 12 h and then elevated in the late phase 24 h after GnRH stimulation. In addition, the mRNA expression levels of Clock genes, including Bmal1, Clock, Per2, and Cry1, also showed temporal changes mimicking the pattern of LHβ expression in the presence and absence of GnRH. Notably, the expression levels of Bmal1 and Clock showed strong positive correlations with LHβ mRNA expression levels. Moreover, a functional link of the ERK signaling of mitogen-activated protein kinases (MAPKs) in the suppression of LHβ mRNA expression, as well as Bmal1 and Clock mRNA expression by GnRH at the early phase, was revealed. Inhibition of Bmal1 and Clock expression using siRNA was involved in the reduction in LHβ mRNA levels in the late phase 24 h after GnRH stimulation. Furthermore, in the presence of BMP-6 and -7, late-phase Bmal1 and LHβ mRNA expression after GnRH stimulation was significantly attenuated. Collectively, the results indicated that LH expression in gonadotrope cells exhibits Bmal1/Clock-dependent fluctuations under the influence of GnRH and that the fluctuations are regulated by ERK and BMPs in the early and late stages, respectively, in a phase-dependent manner after GnRH stimulation.

    DOI: 10.3390/ijms222011186

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  • Calcified spleen associated with Pneumocystis jirovecii infection. 国際誌

    Koichiro Yamamoto, Hiroyuki Honda, Hideharu Hagiya, Fumio Otsuka

    QJM : monthly journal of the Association of Physicians   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/qjmed/hcab260

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  • Validated international definition of the thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly clinical subtype (TAFRO) of idiopathic multicentric Castleman disease. 国際誌

    Yoshito Nishimura, David C Fajgenbaum, Sheila K Pierson, Noriko Iwaki, Asami Nishikori, Mitsuhiro Kawano, Naoya Nakamura, Koji Izutsu, Kengo Takeuchi, Midori Filiz Nishimura, Yoshinobu Maeda, Fumio Otsuka, Kazuyuki Yoshizaki, Eric Oksenhendler, Frits van Rhee, Yasuharu Sato

    American journal of hematology   96 ( 10 )   1241 - 1252   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly (TAFRO) syndrome is a heterogeneous entity manifesting with a constellation of symptoms described above that can occur in the context of idiopathic multicentric Castleman disease (iMCD) as well as infectious diseases, malignancies, and rheumatologic disorders. So, iMCD-TAFRO is an aggressive subtype of iMCD with TAFRO syndrome and often hyper-vascularized lymph nodes. Since we proposed diagnostic criteria of iMCD-TAFRO in 2016, we have accumulated new insights on the disorder and additional cases have been reported worldwide. In this systematic review and cohort analysis, we established and validated a definition for iMCD-TAFRO. First, we searched PubMed and Japan Medical Abstracts Society databases using the keyword "TAFRO" to extract cases. Patients with possible systemic autoimmune diseases and hematologic malignancies were excluded. Our search identified 54 cases from 50 articles. We classified cases into three categories: (1) iMCD-TAFRO (TAFRO syndrome with lymph node histopathology consistent with iMCD), (2) possible iMCD-TAFRO (TAFRO syndrome with no lymph node biopsy performed and no other co-morbidities), and (3) TAFRO without iMCD or other co-morbidities (TAFRO syndrome with lymph node histopathology not consistent with iMCD or other comorbidities). Based on the findings, we propose an international definition requiring four clinical criteria (thrombocytopenia, anasarca, fever/hyperinflammatory status, organomegaly), renal dysfunction or characteristic bone marrow findings, and lymph node features consistent with iMCD. The definition was validated with an external cohort (the ACCELERATE Natural History Registry). The present international definition will facilitate a more precise and comprehensive approach to the diagnosis of iMCD-TAFRO.

    DOI: 10.1002/ajh.26292

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  • 虹彩炎が治療導入の契機となった2型糖尿病の1例

    中本 健太, 本多 寛之, 平 佑貴, 庵谷 紘美, 中野 靖浩, 長谷川 功, 萩谷 英大, 小比賀 美香子, 片岡 仁美, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   555 - 555   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 高用量ステロイド治療が奏功した重症COVID-19妊婦の1例

    山本 紘一郎, 萩谷 英大, 牧 尉太, 岡原 修司, 長谷川 功, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   568 - 568   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • COVID-19肺炎を発症した高Ca血症・肺病変を伴うMEN1の1例

    大塚 勇輝, 田中 秀一, 本多 寛之, 長谷川 功, 萩谷 英大, 小松原 基志, 岸田 雅之, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   548 - 548   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 総合診療におけるカテコールアミン測定の有用性とその解釈

    砂田 匠彦, 花山 宜久, 灘 隆宏, 徳増 一樹, 山本 紘一郎, 中野 靖浩, 長谷川 功, 萩谷 英大, 小比賀 美香子, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   560 - 560   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 心不全・肝不全から発見された高齢橋本病の1例

    上枝 礼佳, 山本 紘一郎, 田中 秀一, 孫 麗那, 本多 寛之, 長谷川 功, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   516 - 516   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • Intravascular lymphoma presenting as spinal cord infarction 国際誌

    Yukichika Yamamoto, Yoshito Nishimura, Misa Okumura, Yuki Otsuka, Kosuke Oka, Kazuhiro Ikeuchi, Hisakazu Nishimori, Kohei Taniguchi, Fumio Otsuka

    Postgrad. Med. J   97 ( 1152 )   672 - 673   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/postgradmedj-2020-138602

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  • Clinical Characteristics of Japanese Patients Who Visited a COVID-19 Aftercare Clinic for Post-Acute Sequelae of COVID-19/Long COVID. 国際誌

    Yuki Otsuka, Kazuki Tokumasu, Yasuhiro Nakano, Hiroyuki Honda, Yasue Sakurada, Naruhiko Sunada, Daisuke Omura, Kou Hasegawa, Hideharu Hagiya, Mikako Obika, Keigo Ueda, Hitomi Kataoka, Fumio Otsuka

    Cureus   13 ( 10 )   e18568   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CUREUS INC  

    Introduction The long-term clinical course, prognosis, and optimal management of symptoms and conditions after the acute phase of coronavirus disease 2019 (COVID-19) remain to be elucidated. The purpose of this study was to clarify the characteristics of patients referred to a COVID-19 aftercare (CAC) clinic established at a tertiary academic hospital in Japan. Methods This study was a descriptive case series study. All patients who visited the CAC clinic between February 15 and September 17 in 2021 were included. Patients' background, chief complaints, and clinical courses after the onset of COVID-19 were described. Results A total of 87 Japanese patients (median age, 40.0 years; interquartile range [IQR], 26.5-53.0 years; 52.9% women) were referred to the CAC clinic. The median interval between the onset of COVID-19 and the visit to the clinic was 79.0 (IQR, 52.5-112.0) days. Referral sources were hospitals (36 patients), clinics (47 patients), a local healthcare center (3 patients), and other (1 patient). The most common chief complaint was general fatigue (50.4%) followed by dysosmia (28.7%), dysgeusia (26.4%), hair loss (18.4%), headache (17.2%), dyspnea (16.1%), and dyssomnia (13.1%). Respiratory symptoms were common in the early stages of the disease but were less common as the chief complaints when visiting the clinic. On the other hand, neurological, psychiatric, and extremity symptoms were predominant one month after the onset of COVID-19. Conclusions Regardless of the severity in the acute phase, patients visiting our CAC clinic suffered from a variety of symptoms. General physicians skilled in using a comprehensive approach would be optimal to see patients with such complex symptoms.

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  • Celiac artery dissection in polycystic kidney disease. 国際誌

    Koichiro Yamamoto, Kou Hasegawa, Kosuke Oka, Fumio Otsuka

    Clinical case reports   9 ( 10 )   e04922   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Autosomal-dominant polycystic kidney disease (ADPKD) is rarely complicated by celiac artery dissection. Dissection of the aorta and its major branches should be carefully differentiated in ADPKD patients with acute-onset abdominal pain.

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  • In vitro effectiveness of biapenem against IMP-producing Enterobacteriaceae. 国際誌

    Kazuyoshi Gotoh, Makoto Miyoshi, I Putu Bayu Mayura, Koji Iio, Osamu Matsushita, Fumio Otsuka, Hideharu Hagiya

    Journal of medical microbiology   70 ( 10 )   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MICROBIOLOGY SOC  

    The options available for treating infections with carbapenemase-producing Enterobacteriaceae (CPE) are limited; with the increasing threat of these infections, new treatments are urgently needed. Biapenem (BIPM) is a carbapenem, and limited data confirming its in vitro killing effect against CPE are available. In this study, we examined the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of BIPM for 14 IMP-1-producing Enterobacteriaceae strains isolated from the Okayama region in Japan. The MICs against almost all the isolates were lower than 0.5 µg ml-1, indicating susceptibility to BIPM, while approximately half of the isolates were confirmed to be bacteriostatic to BIPM. However, initial killing to a 99.9 % reduction was observed in seven out of eight strains in a time-kill assay. Despite the small data set, we concluded that the in vitro efficacy of BIPM suggests that the drug could be a new therapeutic option against infection with IMP-producing CPE.

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  • Impact of the World Antimicrobial Awareness Week on public interest between 2015 and 2020: A Google Trends analysis. 国際誌

    Koichi Keitoku, Yoshito Nishimura, Hideharu Hagiya, Toshihiro Koyama, Fumio Otsuka

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases   111   12 - 20   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCI LTD  

    OBJECTIVES: To evaluate the impact of the World Antimicrobial Awareness Week (WAAW) on public awareness of antimicrobial resistance using Google Trends analysis. METHODS: The impact of WAAW on public awareness of 'antimicrobial resistance' (AMR), 'antibacterial', and 'antibiotics' in Japan, the UK, the United States, and worldwide from 2015 to 2020 was analyzed, using the relative search volume (RSV) of Google Trends as a surrogate. A joinpoint regression analysis was performed to identify a statistically significant time point of a change in trend. RESULTS: No joinpoints around WAAW were identified in Japan, the United Kingdom, or the United States from 2015 to 2020 with RSVs of 'AMR', whereas increasing RSVs were noted worldwide in 2017 and 2020. Further, there were decreasing RSVs of 'antibiotics' in the first half of 2020, which could be due to the COVID-19 pandemic. The study results suggest that WAAW did little to improve public awareness of AMR in the selected countries despite its contribution worldwide. CONCLUSIONS: This study implies that we need to develop a more effective method to improve public awareness to fight against AMR.

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  • COVID-19後の後遺症が診断の契機となったLOH症候群の1例

    副島 佳晃, 中野 靖浩, 徳増 一樹, 大塚 勇輝, 櫻田 泰江, 本多 寛之, 中本 健太, 長谷川 功, 萩谷 英大, 植田 圭吾, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   496 - 496   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 肺非結核性抗酸菌症を合併したACTH分泌不全症の1例

    高瀬 了輔, 中野 靖浩, 山本 紘一郎, 越智 可奈子, 長谷川 功, 三好 智子, 小川 弘子, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   499 - 499   2021年10月

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  • 不明熱精査からirAEによるACTH単独欠損症と診断した2例

    平仲 凪, 山本 紘一郎, 田中 秀一, 孫 麗那, 高橋 美砂, 本多 寛之, 長谷川 功, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   488 - 488   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 炎症性動脈瘤を合併し仮面尿崩症を呈した下垂体機能低下症の1例

    平 佑貴, 中野 靖浩, 中本 健太, 庵谷 紘美, 長谷川 功, 萩谷 英大, 三好 智子, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   491 - 491   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 抗PD-1抗体による早期の甲状腺障害後にACTH分泌不全を呈した1例

    安田 美帆, 山本 紘一郎, 中野 靖浩, 長谷川 功, 越智 可奈子, 三好 智子, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   503 - 503   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 歯科受診を契機に発見された先端巨大症の1例

    中野 靖浩, 中本 健太, 平 佑貴, 庵谷 紘美, 長谷川 功, 三好 智子, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   505 - 505   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • Triad signs shown by bone scintigraphy in FGF23-related osteomalacia. 国際誌

    Koichiro Yamamoto, Hiroyuki Honda, Itsuro Ota, Fumio Otsuka

    QJM : monthly journal of the Association of Physicians   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/qjmed/hcab240

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  • Sternoclavicular Joint Hypertrophy Involved in Polymyalgia Rheumatica.

    Koichiro Yamamoto, Kosuke Oka, Kou Hasegawa, Fumio Otsuka

    Internal medicine (Tokyo, Japan)   60 ( 18 )   3057 - 3057   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    DOI: 10.2169/internalmedicine.6860-20

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  • Ivermectin for Coronavirus Disease 2019: Yet to Be Well Evaluated Before Clinical Use. 国際誌

    Hideharu Hagiya, Fumio Otsuka

    Clinical therapeutics   43 ( 9 )   1622 - 1623   2021年9月

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    記述言語:英語   出版者・発行元:ELSEVIER  

    DOI: 10.1016/j.clinthera.2021.07.007

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  • Gender-Dependent Characteristics of Serum 1,25-Dihydroxyvitamin D/25-Hydroxyvitamin D Ratio for the Assessment of Bone Metabolism. 国際誌

    Manami Fujita-Yamashita, Koichiro Yamamoto, Hiroyuki Honda, Yoshihisa Hanayama, Kazuki Tokumasu, Yasuhiro Nakano, Kou Hasegawa, Hideharu Hagiya, Mikako Obika, Hiroko Ogawa, Fumio Otsuka

    Cureus   13 ( 9 )   e18070   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CUREUS INC  

    Objectives Vitamin D deficiency, which is common worldwide, increases the risks of falls and fractures and can lead to increased morbidity and mortality. However, the clinical utility and relevance of vitamin D activation remain unknown. The aim of the present study was to clarify the clinical usefulness of serum 1,25-dihydroxyvitamin D (1,25D)/25-hydroxyvitamin D (25D) ratio for assessment of the extent of bone metabolism. Methods We retrospectively screened data for 87 patients whose serum 1,25D and 25D levels were measured. Eight patients who were taking vitamin D preparations were excluded, and data for 79 patients (33 males and 46 females) were analyzed. Since menopausal status can be associated with serum vitamin D level, we divided the patients by gender and divided the female patients into two groups at the age of 50 years. Results The median serum 1,25D/25D ratio was significantly lower in males than in females, with the most considerable difference in all males [4.1 (interquartile range: 2.3-5.8) × 10-3] versus elderly females (aged ≧50 years) [7.9 (3.3-10.1) × 10-3). Main disorders were endocrine (30.6%), inflammatory (18.5%), and bone-related (16.7%) disorders. The ratios of serum 1,25D/25D had significant negative correlations with femoral dual-energy X-ray absorptiometry % young adult mean (DEXA %YAM) (R=-0.35) and lumbar DEXA %YAM (R=-0.32). Significant correlations were found between the 1,25D/25D ratio and serum levels of inorganic phosphate (iP), parathyroid hormone, and alkaline phosphatase (ALP). The 1,25D/25D ratio had gender-specific characteristics: the ratio was significantly correlated with age in males (R=-0.49), while it was significantly correlated with BMI in females (R=0.34). Conclusions The results of this study suggested that vitamin D activity is negatively correlated with bone mineral density, being reduced in aged males but enhanced in obese females.

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  • Candidemia in COVID-19 treated with corticosteroids and tocilizumab. 国際誌

    Koichiro Yamamoto, Kaoru Nakamura, Hideharu Hagiya, Fumio Otsuka

    Clinical case reports   9 ( 9 )   e04858   2021年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    COVID-19 patients treated with anti-inflammatory drugs are rarely complicated by candidemia. Since immunosuppressive therapy can blunt inflammatory reactions, clinicians should actively survey latent candidemia during severe COVID-19 treatment.

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  • Total vascular resistance, augmentation index, and augmentation pressure increase in patients with peripheral artery disease. 国際誌

    Rika Takemoto, Haruhito A Uchida, Hironobu Toda, Ken Okada, Fumio Otsuka, Hiroshi Ito, Jun Wada

    Medicine   100 ( 32 )   e26931   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    ABSTRACT: Peripheral arterial disease (PAD) is one of major vascular diseases which frequently coexists with coronary arterial disease and cerebrovascular disease. The patients with PAD have a poor prognosis when it progresses. A new blood pressure testing device enables to simultaneously measure brachial blood pressure (BP), central BP, and several vascular parameters, with easy and non-invasive, in a short time. Here, we aimed to evaluate these arterial stiffness parameters in patients with PAD.In this study, 243 consecutive patients who were suspected of having PAD and referred to our hospital from September 2016 to June 2019, were registered. Several parameters, such as brachial BP, central BP, aortic pulse wave velocity (aPWV), total vascular resistance (TVR), augmentation index (AI) and augmentation pressure (AP), were determined by Mobil-O-Graph. Ankle-brachial pressure index (ABI) was used to define PAD (ABI ≤ 0.9 as PAD). The relationship between PAD and central BP, aPWV, TVR, AI, or AP were investigated.One hundred sixty-two patients (67%) were categorized as the PAD group and 81 patients (33%) as the non-PAD group. In the PAD group, the systolic brachial BP and central systolic BP were significantly higher than those in the non-PAD group (138 ± 24 mmHg vs 131 ± 19 mmHg, P < .05, 125 ± 22 mmHg vs 119 ± 18 mmHg, P < .05, respectively). TVR, AI, and AP were significantly higher in the PAD group (1785 ± 379 dyn s/cm5 vs 1661 ± 317 dyn s/cm5, P < .05, 26.2 ± 13.0% vs 22.2 ± 13.3%, P < .05, 13.5 ± 9.4 mmHg vs 10.7 ± 7.2 mmHg, P < .05, respectively). No significant differences in diastolic BP, central diastolic BP, and aPWV were found between the groups. Multivariate logistic regression analysis revealed that PAD was significantly associated with TVR, AI, and AP (P < .05, respectively).TVR/AP/AI were significantly higher in the PAD group than in the non-PAD group.

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  • Effectiveness of supplemental oral calcium drink in preventing citrate-related adverse effects in peripheral blood progenitor cell collection. 国際誌

    Keiko Fujii, Nobuharu Fujii, Takumi Kondo, Toshiharu Mitsuhashi, Makoto Nakamura, Keisuke Seike, Yasuhisa Sando, Maiko Kimura, Masayuki Matsuda, Shuntaro Ikegawa, Hiroyuki Sugiura, Fumio Otsuka, Yoshinobu Maeda

    Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis   60 ( 4 )   103147 - 103147   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Peripheral blood progenitor cells (PBPCs) are a predominant graft source in allogeneic hematopoietic cell transplantation. Citrate-induced hypocalcemia remains the most frequent side effect of PBPC apheresis. Although the method for preventing severe adverse events is established, more efficient prophylaxis is required so that volunteer donors can donate PBPCs without pain and anxiety. We studied 80 healthy donors who underwent PBPC harvest between February 2014 and June 2020. Of these, 23 donors who underwent apheresis between February 2014 and December 2015 received only the standard prophylaxis of intravenous calcium gluconate. Oral calcium drinks were provided to 57 donors who underwent apheresis from January 2016 to June 2020 to supplement intravenous calcium gluconate prophylaxis. The ionized calcium (ICa) levels at multiple time intervals and the hypocalcemic symptoms were evaluated. Oral supplementation with a calcium drink maintained significantly higher ICa levels. Analysis using the inverse probability weighted regression adjustment method suggested that calcium drinks reduced the frequency of citrate-related reactions by 39.2 %. Administering a prophylactic oral calcium drink before apheresis with intravenous administration of calcium gluconate is promising to further reduce citrate-induced hypocalcemia in volunteer donors.

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  • High-Dose Corticosteroids for a Pregnant Woman Critically Ill With Coronavirus Disease 2019. 国際誌

    Koichiro Yamamoto, Hideharu Hagiya, Jota Maki, Shuji Okahara, Kou Hasegawa, Fumio Otsuka

    Cureus   13 ( 8 )   e17398   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CUREUS INC  

    Pregnancy was reported to be a risk factor for coronavirus disease 2019 (COVID-19), with an increased risk for premature birth. Corticosteroids and remdesivir are used for patients with COVID-19; however, there is no established treatment for these patients. In particular, the effective management of pregnant, critically ill patients with COVID-19 remains unknown. We describe a 34-year-old, critically ill woman at 30 weeks of gestation with COVID-19, who was successfully treated with remdesivir and combined high-dose betamethasone (12 mg/day for two days) and methylprednisolone (125 mg/day for three days) followed by steroid tapering. During treatment, fetal biophysical profile scores on obstetric ultrasound were normal; her pregnancy course progressed well. Since high-dose corticosteroids improve fetal lung maturation and as well as cytokine storm due to COVID-19, this case provides an insight into the management of pregnant COVID-19 patients.

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  • No Association Observed Between the Number of Infectious Disease Experts and Prevalence of Antimicrobial-Resistant Pathogens in Japan. 国際誌

    Hideharu Hagiya, Fumio Otsuka

    Cureus   13 ( 8 )   e16918   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CUREUS INC  

    INTRODUCTION: The global spread of emerging infections has increased the demand for infectious disease (ID) experts. There is no established method to evaluate the sufficiency of professionals on a regional basis. We aimed to determine the correlation of the number of ID doctors and certified nurses in infection control (CNIC) with the prevalence of representative antimicrobial-resistant (AMR) pathogens across the 47 prefectures in Japan using publicly available databases. METHODS: We determined the number of ID doctors and CNIC registered in each prefecture based on the Japanese Association for Infectious Diseases and the Japanese Nursing Association websites and calculated their numbers per 100,000 population. Data on representative AMR pathogens were extracted from the Japan Nosocomial Infections Surveillance database. Spearman's correlation coefficient was used to measure statistical associations. RESULTS: There was no epidemiologically applicable correlation between the deployment of ID doctors and CNIC and the isolation rates of methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, cefotaxime- or levofloxacin-resistant Escherichia coli and Klebsiella pneumoinae, and meropenem-resistant Pseudomonas aeruginosa. Solely, the isolation rate of levofloxacin-resistant K. pneumoinae and the number of CNIC were statistically correlated (correlation coefficient = -0.33; p = 0.02), while the isolation rate of cefotaxime-resistant E. coli was paradoxically correlated with the number of ID doctors (correlation coefficient = 0.33; p = 0.02). Conclusions: Our macroscopic analysis using the open database was not a reliable method to evaluate the sufficiency of ID experts across the prefectures in Japan. A scheme to assess the appropriate distribution of ID experts should be developed.

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  • An Elderly Male with Primary Sjögren's Syndrome Presenting Pleuritis as the Initial Manifestation.

    Yukichika Yamamoto, Yuki Otsuka, Takayuki Katsuyama, Yoshito Nishimura, Kosuke Oka, Kou Hasegawa, Hideharu Hagiya, Fumio Otsuka

    Acta medica Okayama   75 ( 4 )   539 - 542   2021年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    Primary Sjögren's syndrome (SS) is an autoimmune disease that usually affects the exocrine glands in mid-dle-aged women. Fifteen percent of SS patients experience severe systemic extraglandular complications, and pleuritis is one of the rare complications of SS. We report the case of an elderly Japanese man who initially pre-sented with a prolonged fever and chest pain and was finally diagnosed with primary SS-associated pleuritis. Of the nine reported cases of primary SS that initially presented with pleuritis, up to six cases were elderly males. This case highlights the complication of pleuritis among elderly males with primary SS.

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  • High-dose steroids for the treatment of severe COVID-19: comment. 国際誌

    Shuichi Tanaka, Koichiro Yamamoto, Hideharu Hagiya, Kou Hasegawa, Fumio Otsuka

    Internal and emergency medicine   16 ( 5 )   1415 - 1416   2021年8月

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    記述言語:英語   出版者・発行元:SPRINGER-VERLAG ITALIA SRL  

    DOI: 10.1007/s11739-021-02766-0

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  • Pseudo-Cushing's state in a patient with non-functioning pituitary adenoma. 国際誌

    Koichiro Yamamoto, Yoshihisa Hanayama, Fumio Otsuka

    BMJ case reports   14 ( 7 )   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMJ PUBLISHING GROUP  

    DOI: 10.1136/bcr-2021-244438

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  • Trends in the nontuberculous mycobacterial disease mortality rate in Japan: A nationwide observational study, 1997-2016 国際誌

    Ko Harada, Hideharu Hagiya , Tomoko Funahashi , Toshihiro Koyama, Mitsunobu R Kano, Fumio Otsuka

    Clin Infect Dis.   73 ( 2 )   e321-e326 - E326   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/cid/ciaa810

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  • Acute Pancreatitis Related to COVID-19 Infection.

    Koichiro Yamamoto, Kosuke Oka, Hiroyuki Sakae, Fumio Otsuka

    Internal medicine (Tokyo, Japan)   60 ( 13 )   2159 - 2160   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    DOI: 10.2169/internalmedicine.7400-21

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  • Large-vessel Vasculitis Induced by Granulocyte Colony-Stimulating Factor Administration after Chemotherapy 国際誌

    Koichiro Yamamoto, Nayu Tamura, Kosuke Oka, Kou Hasegawa, Hideharu Hagiya , Madoka Hokama, Joji Ishida, Fumio Otsuka

    Mod Rheumatol Case Rep   5 ( 2 )   322 - 326   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Successful deceased donor kidney transplantation to a recipient with a history of COVID-19 treatment. 国際誌

    Kasumi Yoshinaga, Motoo Araki, Koichiro Wada, Kou Hasegawa, Takanori Sekito, Shuji Miyake, Shogo Watari, Yuki Maruyama, Takuya Sadahira, Shingo Nishimura, Katsuyuki Tanabe, Hidemi Takeuchi, Yuri Nakashima, Masaru Kinomura, Herik Acosta, Yosuke Mitsui, Risa Kubota, Hirochika Nakajima, Kohei Edamura, Yasuyuki Kobayashi, Masami Watanabe, Toyohiko Watanabe, Fumio Otsuka, Jun Wada, Yasutomo Nasu

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   27 ( 7 )   1097 - 1101   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER  

    CASE PRESENTATION: A 49-year-old Asian male, who had undergone hemodialysis for >16 years, complained of a fever, dysgeusia and dysosmia, and was diagnosed with COVID-19 pneumonia based on severe acute respiratory syndrome coronavirus 2 polymerase chain reaction (SARS-CoV-2 PCR) and computed tomography (CT). Treatment was started with oral favipiravir and ciclesonide inhalation. On the 10th day of treatment, the patient had a persistent high fever and a chest CT showed exacerbation of pneumonia, so dexamethasone was intravenously started. He was discharged after confirming two consecutive negative SARS-CoV-2 PCR tests. Three months after COVID-19 treatment, a SARS-CoV-2 PCR test was negative and he underwent a deceased donor kidney transplantation. Basiliximab induction with triple drug immunosuppression consisting of extended-release tacrolimus, mycophenolate mofetil and prednisolone, which is our regular immunosuppression protocol, was used. He was discharged on postoperative day 18 without the need for postoperative hemodialysis or any complications. The serum creatinine level was 1.72 mg/dL 95 days postoperatively and he had a favorable clinical course that was similar to deceased donor kidney recipients without a history of SARS-CoV-2 infection. CONCLUSION: We report the first case of a kidney transplantation after COVID-19 treatment in Japan and the fourth case globally. We would like to provide information about our successful case due to the anticipated increase in similar candidates in the near future.

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  • Deployment of Infectious Disease Experts and Prevalence of Antimicrobial Resistance in Okayama: A Call for Training of Specialists. 国際誌

    Hideharu Hagiya, Koji Fujita, Shinya Kamiyama, Kazuki Ocho, Haruto Yamada, Fumio Otsuka

    Cureus   13 ( 7 )   e16643   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:CUREUS INC  

    Objective During the ongoing global pandemic of novel coronavirus disease 2019 (COVID-19), an emerging infectious disease, the implementation and execution of infection prevention and control (IPC) is of paramount importance. In this study, we aimed to assess the current deployment of infection control medical personnel in Okayama prefecture, who are supposed to play an essential role to prevent the outbreak of infectious diseases, and the current prevalence of antimicrobial-resistant (AMR) bacteria isolated in Okayama. Materials and methods This was a descriptive study using publicly available data. The numbers of infectious disease (ID)-doctors and the certified nurses in infection control (CNIC) per 100,000 population in 47 prefectures in Japan were calculated. We then compared the detected proportions of AMR pathogens among the prefectures in 2019 to be employed as a comparative parameter, which was obtained from Japan Nosocomial Infections Surveillance (JANIS) data. Results The number of ID-doctors was the 11th highest in Japan; however, they were unevenly distributed in southern Okayama, particularly at three tertiary hospitals. While the deployment of CNIC was geographically less uneven in the prefecture, their number was lower than the domestic average. According to the JANIS data, isolation rates of AMR pathogens were high in Okayama compared to other prefectures in Japan: vancomycin-resistant Enterococcus faecium (the third-worst); cefotaxime-resistant Escherichia coli and Klebsiella pneumoniae (the third-worst and the second-worst, respectively); and meropenem-resistant Pseudomonas aeruginosa (the worst). Conclusions Our assessment provides underlying data and reinforces the need for educating multi-professional experts in the field of infectious diseases to prevent future public health threats in Okayama.

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  • Barium appendicitis. 国際誌

    Daisuke Omura, Naoko Yunoki, Yuki Otsuka, Yasuhiro Nakano, Hideharu Hagiya, Fumio Otsuka

    Clinical case reports   9 ( 7 )   e04583   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    We have presented a case of barium appendicitis, which is a rare complication of barium enema studies. Barium sulfate is used widely for gastrointestinal radiographic studies and is associated with few complications. Clinicians need to be fully aware of this complication.

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  • A patient with human coronavirus NL63 falsely diagnosed with COVID-19; Lesson learned for the importance of definitive diagnosis. 国際誌

    Yuki Otsuka, Hideharu Hagiya, Yasuhiro Nakano, Daisuke Omura, Kou Hasegawa, Haruto Yamada, Koji Iio, Tomoyuki Honda, Fumio Otsuka

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   27 ( 7 )   1126 - 1128   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER  

    The gold standard for the diagnosis of coronavirus disease 2019 (COVID-19) is a nucleic acid detection test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may occasionally reveal false-positive or false-negative results. Herein, we describe a case of a patient infected with human coronavirus NL63 (HCoV-NL63) who was falsely diagnosed with COVID-19 using the Ampdirect™ 2019-nCoV detection kit (Shimadzu Corporation, Japan) and SARS-CoV-2 Detection Kit (TOYOBO co., ltd.), and was admitted to a COVID-19 hospital ward. We suspected a cross-reaction between HCoV-NL63 and SARS-CoV-2; however, the reported genome sequences of HCoV-NL63 and N1/N2 primers for SARS-CoV-2 do not correspond. Thus, the PCR result was supposed to be a false positive possibly due to contamination or human error. Although the issue of a false-negative result has been the focus of much attention to prevent the spread of the disease, a false positive is fraught with problems as well. Physicians should recognize that unnecessary isolation violates human rights and a careful diagnosis is indispensable when the results of laboratory testing for COVID-19 are unclear. Generally, in cases such as a duplicate PCR test was partially positive, either N1 or N2 alone was positive, PCR testing for two or more target regions resulted in a positive only for single region, a high cycle threshold >35 was obtained, a false positive should be suspected. Especially, when these conditions coincide, we should recognize the high likelihood of a false positive.

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  • Acute pancreatitis without abdominal pain induced by administration of nivolumab and ipilimumab. 国際誌

    Koichiro Yamamoto, Kosuke Oka, Reina Son, Hiroyuki Honda, Hiroyuki Sakae, Kou Hasegawa, Shigeru Horiguchi, Hironari Kato, Osamu Yamasaki, Fumio Otsuka

    Modern rheumatology case reports   5 ( 2 )   425 - 430   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:TAYLOR & FRANCIS LTD  

    Immune checkpoint inhibitors (ICIs) such as nivolumab and ipilimumab are emerging agents for the treatment of cancers including melanoma. ICIs are known to cause immune-related adverse events (irAEs), including the development of enterocolitis, dermatitis, and nephritis. However, ICI-induced pancreatitis has seldom been reported, and its pathophysiology and clinical importance remain largely unknown. We describe a 76-year-old man with melanoma who developed acute pancreatitis without abdominal pain after immunotherapy with nivolumab and ipilimumab. The patient was referred due to 2-week-long general fatigue, anorexia, and dermatitis after his second immunotherapy. Laboratory examinations in serum showed high inflammation and renal dysfunction. Plain computed tomography (CT) on admission showed no new lesions including colitis or pancreatitis. On the 4th day of hospitalisation, serum pancreatic enzymes were extremely elevated. Amylase was increased to 683 U/L (normal range: 44-132) and lipase was increased to 1520 U/L (13-55), but he had no abdominal tenderness. Contrast-enhanced CT showed enlarged pancreatic parenchyma and magnetic resonance cholangiopancreatography showed peripancreatic fat stranding, suggesting pancreatitis. Blood culture tests and empirical antibiotic therapy with ceftriaxone indicated no active infectious diseases. We diagnosed ICI-induced pancreatitis and treated him with 0.5 mg/kg/day of prednisolone, which improved his general fatigue, anorexia, dermatitis, and pancreatitis. The potential significance of asymptomatic elevations of pancreatic enzymes has been unclear; however, this case suggested that ICI-induced pancreatitis without abdominal tenderness could be clinically significant. Clinicians should pay attention to the development of latent pancreatitis in patients receiving ICIs, even those without abdominal pain.

    DOI: 10.1080/24725625.2021.1899444

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  • Preclinical diagnosis and identification of the chimeric CYP11B1/CYP11B2 gene in two pediatric cases of a Japanese family with glucocorticoid-remediable aldosteronism. 国際誌

    Yasuhiro Nakano, Nahoko Iwata, Kanako Ogura-Ochi, Kosei Hasegawa, Akira Hirasawa, Fumio Otsuka

    Hypertension research : official journal of the Japanese Society of Hypertension   44 ( 7 )   891 - 893   2021年7月

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    記述言語:英語   出版者・発行元:SPRINGERNATURE  

    DOI: 10.1038/s41440-021-00633-1

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  • Involvement of BMP-15 in glucocorticoid actions on ovarian steroidogenesis by rat granulosa cells. 国際誌

    Chiaki Kashino, Toru Hasegawa, Yasuhiro Nakano, Nahoko Iwata, Koichiro Yamamoto, Yasuhiko Kamada, Hisashi Masuyama, Fumio Otsuka

    Biochemical and biophysical research communications   559   56 - 61   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ACADEMIC PRESS INC ELSEVIER SCIENCE  

    To elucidate the impact of glucocorticoids on ovarian steroidogenesis and its molecular mechanism by focusing on bone morphogenetic proteins (BMPs), we examined the effect of dexamethasone (Dex) on estradiol and progesterone synthesis by using primary culture of rat granulosa cells. It was revealed that Dex treatment dose-dependently decreased estradiol production but increased progesterone production induced by follicle-stimulating hormone (FSH) by granulosa cells. In accordance with the effects of Dex on estradiol synthesis, Dex suppressed P450arom mRNA expression and cAMP synthesis induced by FSH. Dex treatment in turn enhanced basal as well as FSH-induced levels of mRNAs encoding the enzymes for progesterone synthesis including P450scc and 3βHSD but not StAR and 20αHSD. Of note, Dex treatment significantly upregulated transcription of the BMP target gene Id-1 and Smad1/5/9 phosphorylation in the presence of BMP-15 among the key ovarian BMP ligands. It was also found that Dex treatment increased the expression level of BMP type-I receptor ALK-6 among the type-I and -II receptors for BMP-15. Inhibitory Smad6/7 expression was not affected by Dex treatment. On the other hand, BMP-15 treatment upregulated glucocorticoid receptor (GR) expression in granulosa cells. Collectively, it was revealed that glucocorticoids elicit differential effects on ovarian steroidogenesis, in which GR and BMP-15 actions are mutually enhanced in granulosa cells.

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  • Hypothalamic Mass Detected in Langerhans Cell Histiocytosis

    Ryosuke Takase, Yasuhiro Nakano, Shin Morizane, Fumio Otsuka

    Intern. Med.   60 ( 11 )   1795 - 1795   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.5946-20

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  • Isolated adrenocorticotropin deficiency induced by pembrolizumab for hypopharyngeal cancer: A case report. 国際誌

    Koichiro Yamamoto, Kazuki Tokumasu, Kosuke Oka, Kou Hasegawa, Fumio Otsuka

    Clinical case reports   9 ( 6 )   e04305   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    We report a case of isolated adrenocorticotropin deficiency caused by pembrolizumab. This condition can be fatal, but its rarity causes under-recognition. Oncologists should pay attention to adrenal insufficiency due to pembrolizumab.

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  • Interrelationships Between Serum Levels of Procalcitonin and Inflammatory Markers in Patients Who Visited a General Medicine Department.

    Jo Araki, Kosuke Oka, Koichiro Yamamoto, Yoshihisa Hanayama, Kazuki Tokumasu, Hideharu Hagiya, Hiroko Ogawa, Koichi Itoshima, Fumio Otsuka

    Acta medica Okayama   75 ( 3 )   299 - 306   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    Various laboratory markers of inflammation are utilized in general practice, but their clinical diagnostic significance is often ambiguous. In the present study, we determined the clinical significance of the examination of serum levels of procalcitonin (PCT) by comparing the PCT levels with the levels of other inflammatory markers, based on a retrospective review of 332 PCT-positive patients, including cases of bacterial infection (20.5%), non-specific inflammation (20.8%), neoplasm (9.9%), connective tissue diseases (8.4%), and non-bacterial infection (7.2%), were analyzed. The serum PCT level was highest in the bacterial infection group (1.94 ng/ml) followed by the non-specific inflammatory group (0.58 ng/ml) and neoplastic diseases group (0.34 ng/ml). The serum PCT level was positively correlated with serum levels of C-reactive protein (rho=0.62), soluble interleukin-2 receptor (sIL-2R; rho=0.69), and ferritin, the plasma level of D-dimer, and white blood cell count, and negatively correlated with the serum albumin level (rho=-0.52), hemoglobin concentration, and platelet count. The serum PCT level showed a stronger positive correlation with the serum sIL-2R level than the other biomarkers. The results suggest that an increased PCT level may indicate not only an infectious state but also a non-bacterial inflammatory condition in the diagnostic process in general practice.

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  • Orbital mass and hairy kidney as characteristics of Erdheim-Chester disease. 国際誌

    Koichiro Yamamoto, Kosuke Oka, Kou Hasegawa, Fumio Otsuka

    Clinical case reports   9 ( 6 )   e04333   2021年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis, involving multiple organs. We report a case of ECD with typical features of an orbital mass and "hairy kidneys," whose recognition can lead to early diagnosis and treatment.

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  • Leucine-rich alpha-2 glycoprotein as a marker of mucosal healing in inflammatory bowel disease. 国際誌

    Eriko Yasutomi, Toshihiro Inokuchi, Sakiko Hiraoka, Kensuke Takei, Shoko Igawa, Shumpei Yamamoto, Masayasu Ohmori, Shohei Oka, Yasushi Yamasaki, Hideaki Kinugasa, Masahiro Takahara, Keita Harada, Masaki Furukawa, Kouichi Itoshima, Ken Okada, Fumio Otsuka, Takehiro Tanaka, Toshiharu Mitsuhashi, Jun Kato, Hiroyuki Okada

    Scientific reports   11 ( 1 )   11086 - 11086   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATURE RESEARCH  

    Leucine-rich alpha-2 glycoprotein (LRG) may be a novel serum biomarker for patients with inflammatory bowel disease. The association of LRG with the endoscopic activity and predictability of mucosal healing (MH) was determined and compared with those of C-reactive protein (CRP) and fecal markers (fecal immunochemical test [FIT] and fecal calprotectin [Fcal]) in 166 ulcerative colitis (UC) and 56 Crohn's disease (CD) patients. In UC, LRG was correlated with the endoscopic activity and could predict MH, but the performance was not superior to that of fecal markers (areas under the curve [AUCs] for predicting MH: LRG: 0.61, CRP: 0.59, FIT: 0.75, and Fcal: 0.72). In CD, the performance of LRG was equivalent to that of CRP and Fcal (AUCs for predicting MH: LRG: 0.82, CRP: 0.82, FIT: 0.70, and Fcal: 0.88). LRG was able to discriminate patients with MH from those with endoscopic activity among UC and CD patients with normal CRP levels. LRG was associated with endoscopic activity and could predict MH in both UC and CD patients. It may be particularly useful in CD.

    DOI: 10.1038/s41598-021-90441-x

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  • Droopy eyelid due to IgG4-related dacryoadenitis 国際誌

    Ryosuke Takase, Hideharu Hagiya, Kazuki Tokumasu, Yoshito Nishimura, Atsunobu Sakurai, Kou Hasegawa, Yoshihisa Hanayama, Fumio Otsuka

    Postgrad. Med. J   97 ( 1147 )   333 - 334   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/postgradmedj-2020-138416

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  • Clinical Utility of the Ratio of Urinary Free Cortisol to Aldosterone as an Index for Inflammatory and Metabolic Dysregulation. 国際誌

    Yuki Otsuka, Yasuhiro Nakano, Kazuki Tokumasu, Hiroyuki Honda, Mikako Obika, Kou Hasegawa, Yoshihisa Hanayama, Koichi Itoshima, Fumio Otsuka

    Annals of clinical and laboratory science   51 ( 3 )   352 - 358   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ASSOC CLINICAL SCIENTISTS  

    OBJECTIVE: Urinary free cortisol (UFC) is a reliable marker to avoid cortisol fluctuation and the effects of binding proteins. However, UFC levels are affected by fluid intake and urine volume, and the normal levels range widely. METHODS: To discover the utility of the ratio of urinary cortisol to aldosterone excretions, 246 patients in whom daily excretions of UFC and aldosterone (UAC) were measured were retrospectively analyzed. RESULTS: The UFC/UAC ratio showed significant positive and negative correlations with the levels of serum cortisol (R=0.287) and aldosterone (R=-0.762), respectively. The UFC/UAC ratio increased with aging in female patients, while it was not altered by the level of BMI in either gender. Markers for metabolic and inflammatory status, including hemoglobin A1c (R=0.327), albumin (R=-0.331), C-reactive protein (R=0.317), ferritin (R=0.473), and D-dimer (R=0.569), showed correlations with the ratio of UFC/UAC that were more significant than the correlations with the serum level of cortisol or UFC alone. Of note, the UFC/UAC ratio was shown to be an indicator for the risk of diabetes (AUC: 0.765), hypoalbuminemia (0.839), hyper-CRPemia (0.748), and thrombophilia (0.824), in which the cut-off levels of the UFC/UAC ratio were around 12. CONCLUSION: The UFC/UAC ratio is a variable for detecting metabolic and inflammatory complications related to adrenocortical dysfunction.

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  • Pseudoacromegaly with acromegalic features in radiography. 国際誌

    Koichiro Yamamoto, Kosuke Oka, Hiroyuki Honda, Kou Hasegawa, Fumio Otsuka

    Clinical case reports   9 ( 5 )   e04095   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Pseudoacromegaly is a condition characterized by acromegalic physical features without growth hormone excess, for which radiographic observation has seldom been reported. This is a rare case of pseudoacromegaly.

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  • HIV-associated cerebral lymphoma in an elderly patient.

    Yuki Otsuka, Hideharu Hagiya, Yasuhiro Nakano, Ryu Kimura, Kentaro Fujii, Fumio Otsuka

    Geriatrics & gerontology international   21 ( 5 )   435 - 436   2021年5月

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    記述言語:英語   出版者・発行元:WILEY  

    DOI: 10.1111/ggi.14159

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  • Orexin A Enhances Pro-Opiomelanocortin Transcription Regulated by BMP-4 in Mouse Corticotrope AtT20 Cells. 国際誌

    Satoshi Fujisawa, Motoshi Komatsubara, Naoko Tsukamoto-Yamauchi, Nahoko Iwata, Takahiro Nada, Jun Wada, Fumio Otsuka

    International journal of molecular sciences   22 ( 9 )   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI  

    Orexin is expressed mainly in the hypothalamus and is known to activate the hypothalamic-pituitary-adrenal (HPA) axis that is involved in various stress responses and its resilience. However, the effects of orexin on the endocrine function of pituitary corticotrope cells remain unclear. In this study, we investigated the roles of orexin A in pro-opiomelanocortin (POMC) transcription using mouse corticotrope AtT20 cells, focusing on the bone morphogenetic protein (BMP) system expressed in the pituitary. Regarding the receptors for orexin, type 2 (OXR2) rather than type 1 (OX1R) receptor mRNA was predominantly expressed in AtT20 cells. It was found that orexin A treatment enhanced POMC expression, induced by corticotropin-releasing hormone (CRH) stimulation through upregulation of CRH receptor type-1 (CRHR1). Orexin A had no direct effect on the POMC transcription suppressed by BMP-4 treatment, whereas it suppressed Smad1/5/9 phosphorylation and Id-1 mRNA expression induced by BMP-4. It was further revealed that orexin A had no significant effect on the expression levels of type I and II BMP receptors but upregulated inhibitory Smad6/7 mRNA and protein levels in AtT20 cells. The results demonstrated that orexin A upregulated CRHR signaling and downregulated BMP-Smad signaling, leading to an enhancement of POMC transcription by corticotrope cells.

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  • Dysphagia Induced by Acromegalic Arthropathy

    Manami Fujita, Yasuhiro Nakano, Hiroyuki Sakae, Fumio Otsuka

    Intern Med   60 ( 7 )   1127 - 1128   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.5856-20

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  • An adrenal incidentaloma caused by synchronous and isolated metastasis. 国際誌

    Koichiro Yamamoto, Kosuke Oka, Hiroyuki Honda, Kou Hasegawa, Yoshihisa Hanayama, Tomofumi Watanabe, Yusuke Tominaga, Atsushi Takamoto, Takayuki Hara, Fumio Otsuka

    Clinical case reports   9 ( 4 )   2494 - 2495   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    We report a patient with adrenal incidentaloma due to synchronous and isolated metastasis from lung cancer, which is a relatively rare condition. Close checkups for incidentaloma in oncologic patients are mandatory, leading to successful operation.

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  • 性腺機能低下を伴いコロナ禍で高度肥満を呈した成人21-水酸化酵素欠損症の1例

    山本 紘一郎, 岡 浩介, 長谷川 功, 越智 可奈子, 中野 靖浩, 徳増 一樹, 本多 寛之, 小比賀 美香子, 大塚 文男

    日本内分泌学会雑誌   96 ( 4 )   1041 - 1041   2021年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 高度肥満・性腺機能低下を来した21-水酸化酵素欠損症成人男性の1例

    山本 紘一郎, 岡 浩介, 藤田 茉奈美, 孫 麗那, 長谷川 功, 越智 可奈子, 中野 靖浩, 徳増 一樹, 本多 寛之, 小比賀 美香子, 大塚 文男

    日本内分泌学会雑誌   97 ( 1 )   351 - 351   2021年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 総合診療における血清プロカルシトニン値と炎症・代謝マーカーの関連性

    荒木 晴, 岡 浩介, 山本 紘一郎, 花山 宜久, 徳増 一樹, 萩谷 英大, 小比賀 美香子, 小川 弘子, 糸島 浩一, 大塚 文男

    日本内分泌学会雑誌   97 ( 1 )   338 - 338   2021年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • ビタミンD活性化指標(1,25D/25D比)の臨床的有用性の検討

    藤田 茉奈美, 山本 紘一郎, 本多 寛之, 花山 宜久, 徳増 一樹, 中野 靖浩, 長谷川 功, 小比賀 美香子, 大塚 文男

    日本内分泌学会雑誌   97 ( 1 )   337 - 337   2021年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • グルココルチコイドによる卵胞ステロイド合成調節とBMP分子の関与

    樫野 千明, 長谷川 徹, 中野 靖浩, 山本 紘一郎, 長尾 聡子, 岩田 菜穂子, 鎌田 泰彦, 増山 寿, 大塚 文男

    日本内分泌学会雑誌   96 ( 4 )   1076 - 1076   2021年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • グルココルチコイドによる卵胞顆粒膜細胞のステロイド合成調節とBMP-15の関与

    樫野 千明, 長谷川 徹, 中野 靖浩, 岩田 菜穂子, 山本 紘一郎, 鎌田 泰彦, 増山 寿, 大塚 文男

    日本内分泌学会雑誌   97 ( 1 )   359 - 359   2021年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 副腎皮質ステロイド合成における時計遺伝子およびBMP/activinの関与

    副島 佳晃, 岩田 菜穂子, 中野 靖浩, 山本 紘一郎, 須山 敦仁, 灘 隆宏, 小川 弘子, 大塚 文男

    日本内分泌学会雑誌   97 ( 1 )   281 - 281   2021年4月

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  • 著明なALP高値を契機に発見された若年発症の副甲状腺癌の1例

    長谷川 功, 大塚 勇輝, 原田 洸, 中野 靖浩, 安田 美帆, 萩谷 英大, 三好 智子, 小川 弘子, 小野 早和子, 枝園 忠彦, 平沢 晃, 柳井 広之, 大塚 文男

    日本内分泌学会雑誌   97 ( 1 )   277 - 277   2021年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 副腎皮質ステロイド合成における時計遺伝子およびBMP/activinの関与

    副島 佳晃, 岩田 菜穂子, 中野 靖浩, 山本 紘一郎, 須山 敦仁, 灘 隆宏, 小川 弘子, 大塚 文男

    日本内分泌学会雑誌   97 ( 1 )   228 - 228   2021年4月

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  • Endogenous Bacterial Endophthalmitis Caused by Iliopsoas Abscess.

    Weiying Sun, Yusuke Shiode, Kazuki Tokumasu, Shuhei Kimura, Mio Hosokawa, Shinichiro Doi, Kosuke Takahashi, Ryo Matoba, Fumio Otsuka, Yuki Morizane

    Acta medica Okayama   75 ( 2 )   249 - 253   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    A 79-year-old woman presented to our hospital with a 10-day history of gradually worsening binocular vision and severe backache. Further investigations revealed poor bilateral best-corrected visual acuities (BCVA), bilateral vitreous opacities, gray-white lesions scattered throughout the retina, and a left iliopsoas abscess on CT that later grew out methicillin-sensitive S. aureus. The abscess was drained and intravenous antibiotics were initiated, but the left eye additionally required intravitreal vancomycin. BCVA for both eyes normalized within 1 year. Intramuscular abscess should be considered as a possible primary lesion in cases of endogenous bacterial endophthalmitis.

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  • Trends in the incidence and mortality of legionellosis in Japan: a nationwide observational study, 1999-2017. 国際誌

    Shinnosuke Fukushima, Hideharu Hagiya, Yuki Otsuka, Toshihiro Koyama, Fumio Otsuka

    Scientific reports   11 ( 1 )   7246 - 7246   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:NATURE PORTFOLIO  

    This study examined temporal trend, seasonality, and geographical variations of legionellosis incidence and mortality in Japan. This nationwide observational study used the Japanese Vital Statistics and Infectious Diseases Weekly Report (1999-2017) data to calculate legionellosis crude and age-adjusted incidence and mortality rates per 100,000 population by age and sex. Incidence was compared among the 4 seasons and regional incidence among 47 prefectures. Of 13,613 (11,194 men) people with legionellosis in Japan, 725 (569 men) were fatal. Increasing incidence trend occurred from 0.0004 (1999) to 1.37 (2017) per 100,000 population. People aged ≥ 70 years accounted for 43.1% overall; men's age-adjusted incidence rate was consistently approximately five times higher than for women. Significantly higher incidence occurred in summer than in winter (p = 0.013). Geographically, highest incidence (≥ 2.0 per 100,000 population) occurred in Hokuriku District, with increasing trends in Hokkaido and middle-part of Japan. Estimated fatality rates decreased consistently at 5.9% (95% confidence interval: - 8.1, - 3.5) annually, from 1999 to 2017, with no trend change point. Increasing legionellosis incidence occurred in Japan during 1999-2017, with declining estimated fatality rates. In this aging society and warming world, disease clinical burden may further deteriorate in future due to increasing incidence trends.

    DOI: 10.1038/s41598-021-86431-8

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  • Angina Simultaneously Diagnosed with the Recurrence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. 国際誌

    Koki Li, Yuki Otsuka, Yasuhiro Nakano, Daisuke Omura, Kou Hasegawa, Mikako Obika, Keigo Ueda, Hitomi Kataoka, Fumio Otsuka

    Diagnostics (Basel, Switzerland)   11 ( 3 )   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI  

    Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) mainly affects young adults and can have a potential impact on social functioning. As this syndrome is associated with endothelial dysfunction, the heart can be damaged via ischemia due to endothelial damage. This might potentially lead to heart failure, which accounts for approximately 20% of deaths among patients with ME/CFS. While cardiac ischemia is thought be a pathophysiologically important manifestation of this syndrome, this is not yet reported. Herein, we present a case of a young female with newly diagnosed vasospastic or microvascular angina and concurrent exacerbation of ME/CFS severity. Her anginal symptoms, including exertional chest pain and transient chest discomfort, mimicked those of ME/CFS but were relieved after the administration of a calcium channel blocker. We emphasize the possibility of concurrent angina and exacerbation of ME/CFS and the importance of detecting cardiac ischemia to avoid unfavorable outcomes.

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  • Burnout of Healthcare Workers amid the COVID-19 Pandemic: A Japanese Cross-Sectional Survey. 国際誌

    Yoshito Nishimura, Tomoko Miyoshi, Hideharu Hagiya, Yoshinori Kosaki, Fumio Otsuka

    International journal of environmental research and public health   18 ( 5 )   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:MDPI  

    The coronavirus disease 2019 (COVID-19) global pandemic has drastically changed how we live and work. Amid the prolonged pandemic, burnout of the frontline healthcare professionals has become a significant concern. We conducted a cross-sectional survey study to provide data about the relationship between the COVID-19 pandemic and the prevalence of burnout in healthcare professionals in Japan. Healthcare workers in a single Japanese national university hospital participated in the survey, including basic demographics, whether a participant engaged in care of COVID-19 patients in the past 2 weeks and the Maslach Burnout Inventory. Of those, 25.4% fully answered the survey; 33.3% were doctors and 63.6% were nurses, and 36.3% engaged in care of COVID-19 patients in the past 2 weeks. Compared to those belonging to General Medicine, those in Emergency Intensive Care Unit were at higher risk of burnout (odds ratio (OR), 6.7; 95% CI, 1.1-42.1; p = 0.031). Of those who engaged in care of COVID-19 patients, 50% reported burnout while 6.1% did not (OR 8.5, 95% CI; 1.3-54.1; p = 0.014). The burnout of healthcare workers is a significant concern amid the pandemic, which needs to be addressed for sustainable healthcare delivery.

    DOI: 10.3390/ijerph18052434

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  • Ulcer-like Projection Accompanied by Giant Cell Arteritis

    Yuki Otsuka, Kosuke Oka, Yoshihisa Hanayama, Fumio Otsuka

    Intern Med   60 ( 5 )   819 - 820   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.5963-20

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  • 総合内科診療に潜む内分泌代謝疾患

    大塚 文男, 小比賀 美香子, 長谷川 功, 中野 靖浩, 徳増 一樹

    日本内科学会雑誌   110 ( 3 )   486 - 491   2021年3月

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    記述言語:日本語   出版者・発行元:(一社)日本内科学会  

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  • Simultaneous hot and cold thyroid nodules: Which is malignant? 国際誌

    Yuki Otsuka, Yasuhiro Nakano, Daisuke Omura, Takayuki Iwamoto, Ruiko Hayashi, Fumio Otsuka

    Clinical case reports   9 ( 3 )   1810 - 1811   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Physicians should be aware of the risk of malignancy in patients with toxic multinodular goiter. Radionuclide scan cannot be used to predict the malignant potential of thyroid nodules. A comprehensive evaluation of imaging studies is needed.

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  • Left-sided appendicitis due to situs inversus totalis. 国際誌

    Yuki Otsuka, Ruiko Hayashi, Shinichi Urano, Akihide Yashima, Yasuo Nanba, Fumio Otsuka

    Clinical case reports   9 ( 3 )   1791 - 1792   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Situs inversus may mimic the pain localization of acute abdomen. In patients with acute abdomen, especially elderly patients who are medically healthy, physicians should cautiously diagnose the etiology of acute abdomen in combination with imaging studies.

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  • Gingival lesion leading to a diagnosis of angiosarcoma.

    Yasuhiro Nakano, Yosuke Sazumi, Yuki Mizuta, Hiroyuki Sakae, Fumio Otsuka

    Journal of general and family medicine   22 ( 2 )   90 - 91   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    A man who presented with a gingival tumor was finally diagnosed with angiosarcoma. It is important for primary care physicians to perform checkups of the oral cavity since oral lesions can lead to a diagnosis of serious systemic diseases.

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  • Involvement of clock gene expression, bone morphogenetic protein and activin in adrenocortical steroidogenesis by human H295R cells

    Yoshiaki Soejima, Nahoko Iwata, Yasuhiro Nakano, Koichiro Yamamoto, Atsuhito Suyama, Takahiro Nada, Hiroko Ogawa, Fumio Otsuka

    Endocr J   68 ( 2 )   243 - 250   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1507/endocrj.EJ20-0359

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  • Impact of the COVID-19 Pandemic on the Psychological Distress of Medical Students in Japan: Cross-sectional Survey Study. 国際誌

    Yoshito Nishimura, Kanako Ochi, Kazuki Tokumasu, Mikako Obika, Hideharu Hagiya, Hitomi Kataoka, Fumio Otsuka

    Journal of medical Internet research   23 ( 2 )   e25232   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JMIR PUBLICATIONS, INC  

    BACKGROUND: The COVID-19 pandemic has negatively affected medical education. However, little data are available about medical students' distress during the pandemic. OBJECTIVE: This study aimed to provide details on how medical students have been affected by the pandemic. METHODS: A cross-sectional study was conducted. A total of 717 medical students participated in the web-based survey. The survey included questions about how the participants' mental status had changed from before to after the Japanese nationwide state of emergency (SOE). RESULTS: Out of 717 medical students, 473 (66.0%) participated in the study. In total, 29.8% (141/473) of the students reported concerns about the shift toward online education, mostly because they thought online education would be ineffective compared with in-person learning. The participants' subjective mental health status significantly worsened after the SOE was lifted (P<.001). Those who had concerns about a shift toward online education had higher odds of having generalized anxiety and being depressed (odds ratio [OR] 1.97, 95% CI 1.19-3.28) as did those who said they would request food aid (OR 1.99, 95% CI 1.16-3.44) and mental health care resources (OR 3.56, 95% CI 2.07-6.15). CONCLUSIONS: Given our findings, the sudden shift to online education might have overwhelmed medical students. Thus, we recommend that educators inform learners that online learning is not inferior to in-person learning, which could attenuate potential depression and anxiety.

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  • Positron emission tomography for the diagnosis of prosthetic heart valve endocarditis. 国際誌

    Yuki Otsuka, Hideharu Hagiya, Kosuke Oka, Fumio Otsuka

    BMJ case reports   14 ( 2 )   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMJ PUBLISHING GROUP  

    DOI: 10.1136/bcr-2021-241640

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  • Septic pulmonary emboli caused by Tsukamurella inchonensis: A case report 国際誌

    Kazuyoshi Gotoh , I Putu Bayu Mayura, Hideharu Hagiya, Kyoichi Obata, Tatsuo Ogawa, Koji Iio, Takumi Fujimori, Fumio Otsuka, Osamu Matsushita

    J Infect Chemother   27 ( 2 )   369 - 372   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jiac.2020.09.024

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  • Clinical Characteristics of Low Androgen Status in Males with Type 2 Diabetes Mellitus.

    Jun Hamahara, Hiroyuki Honda, Koichiro Yamamoto, Kazuki Tokumasu, Yoshihisa Hanayama, Hideharu Hagiya, Mikako Obika, Keigo Ueda, Masayuki Kishida, Fumio Otsuka

    Acta medica Okayama   75 ( 1 )   1 - 8   2021年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    To determine the clinical characteristics of low androgen status in adult males with diabetes, we retrospectively analyzed the medical records of patients with type 2 diabetes mellitus in whom serum free testosterone (FT) levels were examined for 1 year. Among the 46 patients (56 ± 1.5 years old), decreases in serum FT levels to < 8.5 pg/ml (indicating the occurrence of late-onset hypogonadism [LOH]) were detected in 18 (39%). The per-centages of patients with low FT levels were high in the ≥ 50 years age group (83%), the HbA1c < 7% group (67%), and the 25 ≤ BMI < 30 kg/m2 group (56%). The serum FT levels tended to decrease age-dependently. The level of HbA1c was significantly correlated with the Heinemann Aging Male Symptoms (AMS) score (R = 0.47). The low-FT group had decreased levels of hemoglobin. Of note, the serum FSH level (R = -0.32) was negatively correlated with the serum FT level, whereas the serum TSH level (R = 0.36) was positively correlated with the serum FT level. Collectively, these results revealed that many diabetic males may have low FT levels and that the AMS score is related to the HbA1c level. A slightly anemic condition, thyroid dysfunction, and obesity (class 1) might be involved in LOH in middle-aged diabetic males.

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  • De-escalation concept and MIC literacy among medical students and clinical residents. 国際誌

    Hideharu Hagiya, Kazuki Tokumasu, Mikako Obika, Fumio Otsuka

    Postgraduate medical journal   2021年1月

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    記述言語:英語   出版者・発行元:BMJ PUBLISHING GROUP  

    DOI: 10.1136/postgradmedj-2020-139562

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  • Without a silhouette. 国際誌

    Yosuke Sazumi, Kazuki Tokumasu, Hideharu Hagiya, Fumio Otsuka

    Clinical case reports   9 ( 1 )   574 - 575   2021年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Primary effusion lymphoma (PEL) is a kind of malignant lymphoma that develops without a tumor mass. A fluid smear is of no use for the diagnosis of miscellaneous condition. Repeated cell-block smear with immunostaining is useful for the diagnosis of PEL.

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  • 男性2型糖尿病患者におけるアンドロゲン低下と臨床的特徴

    浜原 潤, 本多 寛之, 山本 紘一郎, 中野 靖浩, 徳増 一樹, 花山 宜久, 萩谷 英大, 小比賀 美香子, 植田 圭吾, 岸田 雅之, 大塚 文男

    日本内分泌学会雑誌   96 ( 3 )   789 - 789   2021年1月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • Clinical Manifestations of Patients with Influenza Differ by Age : A Prospective, Multi-centered Study in the Setouchi Marine Area.

    Ryosuke Takase, Hideharu Hagiya, Hiroyuki Honda, Yasuhiro Nakano, Hiroko Ogawa, Mikako Obika, Keigo Ueda, Hitomi Kataoka, Yoshihisa Hanayama, Fumio Otsuka

    Acta medica Okayama   75 ( 5 )   567 - 574   2021年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    Influenza potentially has a high mortality rate when it affects the elderly. We aimed to examine the differences in clinical manifestations in patients with influenza according to their age. This multicenter prospective study was performed in six medical institutions in Okayama and Kagawa prefectures (Japan). Between December 1, 2019 and March 31, 2020, we collected data on adult patients diagnosed with influenza type A, who were strat-ified into younger (20-49 years), middle-aged (50-64 years), and older groups (≥ 65 years). We compared the presence or absence of fever, respiratory symptoms, and extrapulmonary symptoms according to age group. In total, 203 patients (113, younger; 51, middle-aged; and 39, older) were eligible for the analysis. The maxi-mum body temperature and temperature at first physician visit in the older group were significantly lower than those in the younger group. The incidence of respiratory symptoms was not different among the three groups. Chills, muscle pain, and arthralgia as systemic symptoms were noted significantly more frequently in the younger (80.9%) and middle-aged (75.5%) groups than in the older group (51.3%) (p = 0.002). Fever and sys-temic symptoms were less likely to appear in older patients, possibly resulting in the delaying of hospital visits among older adults.

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  • Antimicrobial prescription practices for outpatients with acute respiratory tract infections: A retrospective, multicenter, medical record-based study. 国際誌

    Tomoharu Ishida, Hideharu Hagiya, Hiroyuki Honda, Yasuhiro Nakano, Hiroko Ogawa, Mikako Obika, Keigo Ueda, Hitomi Kataoka, Yoshihisa Hanayama, Fumio Otsuka

    PloS one   16 ( 11 )   e0259633   2021年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Antimicrobial stewardship for outpatients with acute respiratory tract infections (ARTIs) should be urgently promoted in this era of antimicrobial resistance. Previous large-sample studies were based on administrative data and had limited reliability. We aimed to identify current antimicrobial prescription practices for ARTIs by directly basing on medical records. This multicenter retrospective study was performed from January to December in 2018, at five medical institutes in Japan. We targeted outpatients aged ≥18 years whose medical records revealed International Classification of Diseases (ICD-10) codes suggesting ARTIs. We divided the eligible cases into three age groups (18-64 years, 65-74 years, and ≥75 years). We defined broad-spectrum antimicrobials as third-generation cephalosporins, macrolides, fluoroquinolones, and faropenem. Primary and secondary outcomes were defined as the proportion of antimicrobial prescriptions for the common cold and other respiratory tract infections, respectively. Totally, data of 3,940 patients were collected. Of 2,914 patients with the common cold, 369 (12.7%) were prescribed antimicrobials. Overall, compared to patients aged ≥75 years (8.5%), those aged 18-64 years (16.6%) and those aged 65-74 years (12.1%) were frequently prescribed antimicrobials for the common cold (odds ratio [95% confidential interval]; 2.15 [1.64-2.82] and 1.49 [1.06-2.09], respectively). However, when limited to cases with a valid diagnosis of the common cold by incorporating clinical data, no statistical difference was observed among the age groups. Broad-spectrum antimicrobials accounted for 90.2% of the antimicrobials used for the common cold. Of 1,026 patients with other respiratory infections, 1,018 (99.2%) were bronchitis, of which antimicrobials were prescribed in 49.9% of the cases. Broad-spectrum antimicrobials were the main agents prescribed, accounting for nearly 90% of prescriptions in all age groups. Our data suggested a favorable practice of antimicrobial prescription for outpatients with ARTIs in terms of prescribing proportions, or quantitative aspect. However, the prescriptions were biased towards broad-spectrum antimicrobials, highlighting the need for further antimicrobial stewardship in the outpatient setting from a qualitative perspective.

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  • Recurrence of Hypoglycemic Coma in a Patient with Anorexia Nervosa.

    Koichiro Yamamoto, Daisuke Omura, Mai Yamane, Reina Son, Kou Hasegawa, Hiroyuki Honda, Mikako Obika, Nozomu Minao, Satoru Edahiro, Norihito Yamada, Fumio Otsuka

    Acta medica Okayama   75 ( 5 )   631 - 636   2021年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    Anorexia nervosa (AN) is occasionally complicated with hypoglycemic coma, which may cause sudden death by unknown mechanisms. We present the case of a 36-year-old woman with recurrent comas and a nineteen-year history of AN. She was found in a coma with remarkable hypoglycemia (28 mg/dL). Her BMI was 11.1 kg/m2. Endocrine workup revealed extremely low serum levels of glucagon, IGF-I and insulin. Asymptomatic hypoglycemia occurred with liver injury in the refeeding process. An aberrant glucose metabolism due to liver damage might have been involved in her susceptibility to hypoglycemia. This case suggests a possible mechanism of hypoglycemic coma in AN.

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  • Involvement of serum dehydroepiandrosterone sulfate in erythropoietic activity. 国際誌

    Harada K, Hanayama Y, Obika M, Itoshima K, Okada K, Otsuka F

    Aging Male   23 ( 5 )   756 - 763   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/13685538.2019.1592151

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  • Intra-arterial gas, a clue for diagnosis of peri-aortic inflammation due to infection 国際誌

    Daisuke Omura, Masatoshi Ogata, Yoshio Sakane, Ryuichi Matsuo, Harushige Nakatsukasa, Hideharu Hagiya, Fumio Otsuka

    Clin. Case Rep.   8 ( 12 )   3619 - 3620   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/ccr3.3367

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  • A rare complication: Infection in acromegalic renal cysts. 国際誌

    Yuki Mori, Yuki Otsuka, Yasuhiro Nakano, Hiroyuki Sakae, Kou Hasegawa, Fumio Otsuka

    Clinical case reports   8 ( 12 )   3551 - 3552   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Renal cysts are detected in one third of acromegaly patients, especially in uncontrolled cases. Clinicians should pay attention to unexpected infection of enlarged renal cysts in acromegaly patients.

    DOI: 10.1002/ccr3.3108

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  • Clinical Application of the Ratio of Serum Bone Isoform to Total Alkaline Phosphatase in General Practice

    Yuya Yokota, Yoshito Nishimura, Akemi Ando, Yoshihisa Hanayama, Kou Hasegawa, Hideharu Hagiya, Hiroko Ogawa, Mikako Obika, Keigo Ueda, Fumio Otsuka

    Acta Med. Okayama   74 ( 6 )   467 - 474   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18926/AMO/61205

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  • Clinical relevance of insulin-like growth factor-1 to cardiovascular risk markers 国際誌

    Harada K, Hanayama Y, Obika M, Itoshima K, Okada K, Otsuka F

    Aging Male   23 ( 5 )   1030 - 1038   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/13685538.2019.1657083

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  • Comparison of the Clinico-Microbiological Characteristics of Culture-Positive and Culture-Negative Septic Pulmonary Embolism: A 10-Year Retrospective Study 国際誌

    Yoshito Nishimura, Hideharu Hagiya, Mikako Obika , Fumio Otsuka

    Pathogens   9 ( 12 )   9 - 12   2020年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3390/pathogens9120995

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  • Efficacy of HLA virtual cross-matched platelet transfusions for platelet transfusion refractoriness in hematopoietic stem cell transplantation (vol 60, pg 473, 2020)

    Keisuke Seike, Nobuharu Fujii, Naomi Asano, Shigenori Ohkuma, Yasushi Hirata, Keiko Fujii, Yasuhisa Sando, Makoto Nakamura, Kazunori Naito, Yusuke Meguri, Noboru Asada, Daisuke Ennishi, Hisakazu Nishimori, Ken-ichi Matsuoka, Kazuo Tsubaki, Fumio Otsuka, Yoshinobu Maeda

    TRANSFUSION   60 ( 11 )   2765 - 2765   2020年11月

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    記述言語:英語   出版者・発行元:WILEY  

    DOI: 10.1111/trf.15872

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  • Adult-onset Still's disease accompanying noninfective endocarditis.

    Kosuke Oka, Yokota Yuya, Miho Yasuda, Fumio Otsuka

    Journal of general and family medicine   21 ( 6 )   268 - 269   2020年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Adult-onset Still's disease can develop valve lesions. Since AOSD may complicate valvular lesion, differentiation of endocarditis in patients with AOSD is required.

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  • Ectopic hyperparathyroidism due to an auto-transplanted parathyroid gland 国際誌

    Ko Harada, Fumio Otsuka

    Clin. Case Rep   8 ( 11 )   2312 - 2313   2020年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/ccr3.3136

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  • Massive pheochromocytoma. 国際誌

    Terumitsu Anai, Kosuke Oka, Yuya Yokota, Yoshito Nishimura, Hideharu Hagiya, Fumio Otsuka

    Clinical case reports   8 ( 11 )   2308 - 2309   2020年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Complications of pheochromocytoma, such as hypertensive emergency, can be critical. Clinicians should recognize that pheochromocytoma is not uncommon in patients with large adrenal tumors, and screening should be undertaken prior to any intervention.

    DOI: 10.1002/ccr3.3124

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  • Similar safety and efficacy in previously treated adults with growth hormone deficiency randomized to once-weekly somapacitan or daily growth hormone 国際誌

    Fumio Otsuka, Yutaka Takahashi, Shigeyuki Tahara, Yoshihisa Ogawa, Michael H?jby Rasmussen, Koji Takano

    Clin. Endocrinol.   93 ( 5 )   620 - 628   2020年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/cen.14273

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  • Localized Lymph Node Light Chain Amyloidosis

    Akira Yamamoto, Nobuharu Fujii, Mikako Obika, Taro Yamashita, Fumio Otsuka

    Intern. Med   59 ( 19 )   2415 - 2418   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.4651-20

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  • Antibiotic literacy among Japanese medical students. 国際誌

    Hideharu Hagiya, Hideo Ino, Kazuki Tokumasu, Hiroko Ogawa, Tomoko Miyoshi, Kanako Ochi, Fumio Otsuka

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   26 ( 10 )   1107 - 1109   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER  

    Antimicrobial resistance (AMR) is an urgent global issue. After the AMR action plan was introduced in 2016, a study on antibiotic literacy (i.e., awareness, knowledge, and attitude relating to antimicrobial use) among clinicians and lay people was conducted in Japan. However, no studies have hitherto targeted medical students who are expected to have a high level of antibiotic literacy. The present study was conducted between September 2019 and February 2020, enrolling undergraduate students at Okayama University Medical School. We collected data using a paper-based questionnaire form with 11 questions about antibiotic literacy. The response rate was 93.8% (661/705 students). Overall, 92.6% of the students knew that antibiotics inhibit the growth of bacteria. Student reporting that antibiotics could treat the common cold accounted for 77.0% (Year 1), 50.9% (Year 2), 48.2% (Year 3), 49.1% (Year 4), 23.8% (Year 5), and 26.2% (Year 6). Only 43 (6.5%) had heard about the AMR action plan. The study data suggested that medical students' level of literacy on antimicrobial use should be further enhanced to address AMR and promote antimicrobial stewardship.

    DOI: 10.1016/j.jiac.2020.06.021

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  • ALP高値から上縦隔に発見されたMEN1疑い副甲状腺機能亢進症の1例

    大塚 勇輝, 西村 義人, 原田 洸, 岡 浩介, 長谷川 功, 小川 弘子, 三好 智子, 花山 宜久, 枝園 忠彦, 平沢 晃, 大塚 文男

    日本内分泌学会雑誌   96 ( 2 )   549 - 549   2020年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • CYP11B1/B2キメラ遺伝子を確認した家族性アルドステロン症小児例

    中野 靖浩, 岩田 菜穂子, 長谷川 高誠, 越智 可奈子, 山本 紘一郎, 高瀬 了輔, 長谷川 功, 堀口 繁, 山本 英喜, 平沢 晃, 大塚 文男

    日本内分泌学会雑誌   96 ( 2 )   535 - 535   2020年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 男性2型糖尿病患者におけるLOH症候群の潜在と臨床的特徴

    浜原 潤, 本多 寛之, 山本 絋一郎, 中野 靖浩, 徳増 一樹, 花山 宜久, 萩谷 英大, 小比賀 美香子, 植田 圭吾, 岸田 雅之, 大塚 文男

    日本内分泌学会雑誌   96 ( 2 )   544 - 544   2020年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • Clinical Relevance of Serum Prolactin Levels to Inflammatory Reaction in Male Patients

    Koichiro Yamamoto, Yoshihisa Hanayama, Kou Hasegawa, Kazuki Tokumasu, Tomoko Miyoshi , Hideharu Hagiya, Hiroko Ogawa, Mikako Obika, Koichi Itoshima, Fumio Otsuka

    Acta Med. Okayama   74 ( 5 )   381 - 389   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18926/AMO/60797

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  • Generation of four induced pluripotent stem cell lines (FHUi003-A, FHUi003-B, FHUi004-A and FHUi004-B) from two affected individuals of a familial neurohypophyseal diabetes insipidus family 国際誌

    Satoru Yoshida, Hanayuki Okura, Hidetaka Suga, Mika Soen, Yohei Kawaguchi, Junki Kurimoto, Takashi Miyata, Hiroshi Takagi, Hiroshi Arima, Tatsuya Fujikawa, Fumio Otsuka, Akifumi Matsuyama

    Stem Cell Res   48   101960 - 101960   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.scr.2020.101960

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  • Aldosterone enhances progesterone biosynthesis regulated by bone morphogenetic protein in rat granulosa cells 国際誌

    Yasuhiro Nakano, Toru Hasegawa, Chiaki Kashino, Nahoko Iwata, Koichiro Yamamoto, Atsuhito Suyama, Yoshiaki Soejima, Takahiro Nada, Fumio Otsuka

    J Steroid Biochem Mol Biol   203   105738 - 105738   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jsbmb.2020.105738

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  • Disseminated Mycobacterium genavense infection mimicking TAFRO syndrome 国際誌

    Kosuke Oka, Mai Yamane, Yuya Yokota, Miho Yasuda, Kou Hasegawa, Takumi Fujimori , Koji Iio, Hideharu Hagiya, Fumio Otsuka

    J. Infect. Chemother.   26 ( 10 )   1095 - 1099   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jiac.2020.06.020

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  • A nationwide trend analysis in the incidence and mortality of Creutzfeldt-Jakob disease in Japan between 2005 and 2014 国際誌

    Yoshito Nishimura, Ko Harada, Toshihiro Koyama, Hideharu Hagiya , Fumio Otsuka

    Sci Rep   10 ( 1 )   15509 - 15509   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/s41598-020-72519-0

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  • Hashimoto's hyroiditis and primary thyroid lymphoma

    Y Otsuka, M Yasuda, K Tokumasu, K Hasegawa, F Otsuka

    QJM   0 ( 0 )   691 - 692   2020年9月

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    記述言語:英語  

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  • Bilateral massive empyema with bronchopleural fistula. 国際誌

    Harada K, Hagiya H, Otsuka F

    Postgrad. Med. J.   96 ( 1139 )   573 - 573   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/postgradmedj-2019-137328

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  • Hepatic encephalopathy due to extrahepatic portosystemic shunt 国際誌

    Yosuke Sazumi, Yoshito Nishimura, Yuki Otsuka, Yuki Mizuta, Yasuhiro Nakano, Hiroyuki Sakae, Fumio Otsuka

    Clin. Case Rep   8 ( 9 )   1852 - 1853   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/ccr3.2986

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  • Calcinosis Cutis 国際誌

    Ko Harada, Ei Miyasaka, Fumio Otsuka

    Am. J. Med   133 ( 9 )   e528-e529 - E529   2020年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.amjmed.2020.01.040

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  • A rare case of oncocytic adrenocortical carcinoma clinically presented as an incidentaloma

    Ko Harada, Miho Yasuda, Yasuhiro Nakano, Kazuhiro Yoshida, Yuzo Umeda, Takahito Yagi, Yuto Yamazaki , Hironobu Sasano, Fumio Otsuka

    Endocr. J.   67 ( 8 )   883 - 888   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1507/endocrj.EJ20-0024

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  • Multiple Deep-seated Dentofacial Abscesses Caused by Multidrug-resistant Viridans Group Streptococci

    Shinnosuke Fukushima, Hideharu Hagiya, Yuki Mizuta, Yasuhiro Nakano, Masahiro Takahara, Kayo Okamoto, Yuko Hayashi , Kiyoshi Yamada, Kou Hasegawa, Fumio Otsuka

    Intern. Med   59 ( 16 )   2067 - 2070   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.4283-20

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  • Coronary Spastic Angina Induced by Adrenal Insufficiency

    Yuki Otsuka, Ko Harada, Miho Yasuda, Yasuhiro Nakano, Kou Hasegawa, Fumio Otsuka

    Intern. Med   59 ( 15 )   1873 - 1877   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.4337-19

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  • Mycobacterium chelonae bloodstream infection induced by osteomyelitis of toe: A case report 国際誌

    Yayoi Ueda, Kazuki Tokumasu, Hideharu Hagiya, Koji Iio, Takumi Fujimori, Ayaka Kakehi, Mami Okura, Hiroshi Minabe, Fumio Otsuka

    J. Infect. Chemother.   26 ( 8 )   843 - 846   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jiac.2020.03.004

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  • グルココルチコイドによる卵胞ステロイド合成への影響とBMPの関与

    樫野 千明, 長谷川 徹, 中野 靖浩, 長尾 聡子, 岩田 菜穂子, 鎌田 泰彦, 増山 寿, 大塚 文男

    日本内分泌学会雑誌   96 ( 1 )   376 - 376   2020年8月

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  • 相対的副腎不全により冠攣縮性狭心症が惹起された1例

    大塚 勇輝, 安田 美帆, 中野 靖浩, 長谷川 功, 萩谷 英大, 三好 智子, 小比賀 美香子, 片岡 仁美, 大塚 文男

    日本内分泌学会雑誌   96 ( 1 )   372 - 372   2020年8月

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  • アルドステロンによる卵胞プロゲステロン分泌の増強とBMP-6の関与

    中野 靖浩, 長谷川 徹, 樫野 千明, 長尾 聡子, 灘 隆宏, 岩田 菜穂子, 大塚 文男

    日本内分泌学会雑誌   96 ( 1 )   304 - 304   2020年8月

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  • Invasive non-typeable Haemophilus influenzae infection due to endometritis associated with adenomyosis 国際誌

    Yoshito Nishimura, Hideharu Hagiya, Kaoru Kawano, Yuya Yokota, Kosuke Oka, Koji Iio , Kou Hasegawa, Mikako Obika, Tomoko Haruma, Sawako Ono, Hisashi Masuyama, Fumio Otsuka

    BMC Infec. Dis   20 ( 1 )   521 - 521   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s12879-020-05193-2

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  • Clinical and biochemical characteristics of patients having general symptoms with increased serum IgG4. 国際誌

    Hasegawa K, Hanayama Y, Obika M, Miyoshi T, Ogawa H, Kondo E, Kataoka H, Sato Y, Otsuka F

    Mod Rheumatol   30 ( 4 )   721 - 728   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1080/14397595.2019.1642291

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  • 大学病院における研修医メンター制度 メンターの視点、メンティーの視点

    佐藤 明香, 小河 七子, 植田 真司, 矢野 修也, 小川 弘子, 三好 智子, 難波 志穂子, 大塚 文男

    医学教育   51 ( Suppl. )   226 - 226   2020年7月

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    記述言語:日本語   出版者・発行元:(一社)日本医学教育学会  

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  • Vision loss, tractional retinal detachment, and profound anemia due to rectal carcinoma 国際誌

    Akira Yamamoto, Yoshito Nishimura, Mikako Obika, Yuki Morizane, Fumio Otsuka

    Clin. Case Rep   8 ( 7 )   1304 - 1305   2020年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/ccr3.2833

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  • Macromolecules detected in highly increased serum luteinizing hormone

    K Ogura-Ochi, K Itoshima, Y Kamada, F Otsuka

    J. Endocrinol. Invest.   856 - 866   2020年6月

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  • X-linked Hypophosphatemia (XLH) Mimicking Rheumatic Disease 査読

    Ryosuke Takase, Yasuhiro Nakano, Kosei Hasegawa, Fumio Otsuka

    Intern. Med.   59 ( 9 )   1233 - 1234   2020年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.4029-19

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  • Clinical Significance of Total Vascular Resistance, Augmention Index and Augmentation Pressure in Patients With Peripheral Artery Disease

    Rika Takemoto, Haruhito A. Uchida, Nozomu Otaka, Shugo Okamoto, Mariko Nishiwaki, Yasuhiro Onishi, Natsumi Matsuoka, Yoshiko Hada, Hironobu Toda, Fumio Otsuka, Hiroshi Ito, Jun Wada

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   40   2020年5月

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    記述言語:英語   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • An Endoscopic Biopsy Specimen Contains Adequate Lymphocytes for Flow Cytometric Analysis of Light Chain Expression in the Gastrointestinal Mucosa 国際誌

    Masaya Iwamuro, Katsunori Matsueda, Takahide Takahashi, Sizuma Omote, Takehiro Tanaka, Daisuke Ennishi, Fumio Otsuka, Tadashi Yoshino, Hiroyuki Okada

    Ann. Clin. Lab. Sci.   50 ( 3 )   348 - 353   2020年5月

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  • Rigid Ears and Hyperpigmentation in Addison's Disease 国際誌

    Ko Harada, Fumio Otsuka

    Am. J. Med.   133 ( 5 )   e192   2020年5月

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  • Cardiac mucosa-associated lymphoid tissue lymphoma in IgG4-related disease. 国際誌

    Harada K, Otsuka F

    Euro Heart J.   41 ( 15 )   1519 - 1519   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1093/eurheartj/ehz764

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  • Malignant Lymphoma Developed in the Hypothalamus

    Ryosuke Takase, Yasuhiro Nakano, Fumio Otsuka

    Intern. Med.   59 ( 7 )   1009 - 1010   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.3655-19

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  • Gastrointestinal: Massive right pleural effusion caused by a pancreaticopleural fistula

    K Tokumasu, K Harada, F Otsuka

    J. Gastroenterol. Hepatol.   525   2020年4月

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  • Observer agreement for the diagnosis of intestinal acute graft-vs.-host disease based on the presence of villous atrophy in the terminal ileum 国際誌

    Yuusaku Sugihara, Sakiko Hiraoka, Eriko Yasutomi , Shohei Oka, Yasushi Yamasaki, Toshihiro Inokuchi , Hideaki Kinugasa, Masahiro Takahara, Yuki Morito, Sakuma Takahashi, Keita Harada, Takehiro Tanaka, Fumio Otsuka, Hiroyuki Okada

    Exp. Ther. Med   19 ( 4 )   3076 - 3080   2020年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3892/etm.2020.8538

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  • Albright’s Hereditary Osteodystrophy

    Ko Harada , Fumio Otsuka

    QJM   2020年3月

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  • Osmotic Demyelination Syndrome Triggered by Pituitary Apoplexy

    Yuya Yokota, Kosuke Oka, Miho Yasuda, Fumio Otsuka

    Intern. Med   59 ( 6 )   869 - 870   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.3678-19

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  • Efficacy of HLA virtual cross-matched platelet transfusions for platelet transfusion refractoriness in hematopoietic stem cell transplantation 国際誌

    Keisuke Seike, Nobuharu Fujii, Naomi Asano, Shigenori Ohkuma, Yasushi Hirata, Keiko Fujii, Yasuhisa Sando, Makoto Nakamura, Kazunori Naito, Kyosuke Saeki, Yusuke Meguri, Noboru Asada, Daisuke Ennishi, Hisakazu Nishimori, Ken-Ichi Matsuoka , Kazuo Tsubaki, Fumio Otsuka, Yoshinobu Maeda

    Transfusion.   60 ( 3 )   473 - 478   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/trf.15664

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  • Calciphylaxis of the fingers

    Ko Harada, Jo Araki, Kazuki Tokumasu, Hideharu Hagiya, Fumio Otsuka

    J Gen Fam Med.   21 ( 2 )   25 - 26   2020年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jgf2.296

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  • A Comparison of the Clinical Characteristics of TAFRO Syndrome and Idiopathic Multicentric Castleman Disease in General Internal Medicine: A 6-Year Retrospective Study. 国際誌

    Nishimura Y, Hanayama Y, Fujii N, Kondo E, Otsuka F

    Intern. Med. J.   50 ( 2 )   184 - 191   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1111/imj.14404

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  • グルココルチコイドとBMPによる卵胞ステロイド合成調節への影響

    樫野 千明, 長谷川 徹, 中野 靖浩, 長尾 聡子, 岩田 菜穂子, 鎌田 泰彦, 増山 寿, 大塚 文男

    日本内分泌学会雑誌   95 ( 4 )   1556 - 1556   2020年2月

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  • 卵胞プロゲステロン産生におけるアルドステロンとBMP-6の影響

    中野 靖浩, 長谷川 徹, 樫野 千明, 長尾 聡子, 灘 隆宏, 岩田 菜穂子, 西山 悠紀, 細谷 武史, 大塚 文男

    日本内分泌学会雑誌   95 ( 4 )   1514 - 1514   2020年2月

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  • Clinical Relevance of Blood Glucose and Gastroesophageal Reflux Symptoms to Depressive Status in Patients with Type 2 Diabetes Mellitus

    Hiroyuki Honda, Yoshihisa Hanayama, Mikako Obika, Kou Hasegawa, Jun Hamahara, Masayuki Kishida , Hideharu Hagiya, Hiroko Ogawa, Hitomi Kataoka, Fumio Otsuka

    Acta Med Okayama   74 ( 1 )   33 - 40   2020年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18926/AMO/57950

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  • Panda and lambda sign' in sarcoidosis

    K Harada, M Yasuda, F Otsuka

    QJM   113 ( 1 )   61 - 62   2020年1月

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  • Purple Urine Bag Syndrome.

    Ko Harada, Chihiro Hiraiwa, Ei Miyasaka and Fumio Otsuka

    J. Hosp. Gen. Med.   2020年1月

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  • Dysgeusia in a Psychiatric Patient: A Case of Chronic Lithium Intoxication.

    Harada K, Tokumasu K, Hagiya H, Obika M and Otsuka F:

    J. Hosp. Gen. Med.   116 - 120   2020年1月

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  • Technique for single-step lymphocyte isolation from an endoscopic biopsy specimen for the diagnosis of gastrointestinal lymphoma 国際誌

    Masaya Iwamuro, Takahide Takahashi, Natsuki Watanabe, Sizuma Omote, Katsunori Matsueda, Takehiro Tanaka, Daisuke Ennishi, Fumio Otsuka, Tadashi Yoshino, Hiroyuki Okada

    MethodsX   7   101095 - 101095   2020年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.mex.2020.101095

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  • Correlations between depressive conditions and gastroesophageal reflux symptoms in patients visiting a department of general medicine.

    Suganami Y, Oka K, Hanayama Y, Honda H, Hamahara J, Obika M, Kariyama K, Kishida M, Otsuka F

    Acta Med. Okayama   73 ( 6 )   479 - 486   2019年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18926/AMO/57711

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  • “Small Heart Syndrome” with orthostatic hypotension.

    Harada K, Yasuda M, Otsuka F

    Intern. Med.   58 ( 22 )   3337 - 3338   2019年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.2673-19

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  • 冠攣縮性狭心症との関連が疑われた副腎皮質機能低下症の1例

    大塚 勇輝, 安田 美帆, 中野 靖浩, 山本 晃, 長谷川 功, 萩谷 英大, 小比賀 美香子, 片岡 仁美, 大塚 文男

    日本病院総合診療医学会雑誌   15 ( 6 )   590 - 590   2019年11月

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    記述言語:日本語   出版者・発行元:(一社)日本病院総合診療医学会  

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  • Risk Factors for Low Bone Mineral Density Determined in Patients in a General Practice Setting.

    Ando A, Mitsuhashi T, Honda M, Hanayama Y, Hasegawa K, Obika M, Kataoka H, Otsuka F

    Acta Med.Okayama   73 ( 5 )   403 - 411   2019年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18926/AMO/57370

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  • AVシャントによる著明な拡張血管を伴った褐色細胞腫の1例 査読

    山岡 主知, 稲垣 兼一, 森本 栄作, 藤澤 諭, 西山 悠紀, 小松原 基志, 原 孝行, 細谷 武史, 当真 貴志雄, 越智 可奈子, 大塚 文男, 和田 淳

    日本内分泌学会雑誌   95 ( 2 )   806 - 806   2019年10月

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  • 家族性孤発性副甲状腺機能亢進症が疑われる2症例 査読

    西山 悠紀, 稲垣 兼一, 藤澤 諭, 森本 栄作, 小松原 基志, 原 孝行, 細谷 武史, 当真 貴志雄, 越智 可奈子, 大塚 文男, 和田 淳

    日本内分泌学会雑誌   95 ( 2 )   791 - 791   2019年10月

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  • 遺伝性出血性末梢血管拡張症に合併したパラガングリオーマの一例 査読

    藤澤 諭, 稲垣 兼一, 当真 貴志雄, 森本 栄作, 西山 悠紀, 小松原 基志, 原 孝行, 細谷 武史, 越智 可奈子, 三好 智子, 大塚 文男, 竹越 一博, 和田 淳

    日本内分泌学会雑誌   95 ( 2 )   748 - 748   2019年10月

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  • Composite pheochromocytomaの1例 査読

    原 孝行, 稲垣 兼一, 森本 栄作, 西山 悠紀, 藤澤 諭, 小松原 基志, 越智 可奈子, 細谷 武史, 当真 貴志雄, 三好 智子, 小林 泰之, 大塚 文男, 竹越 一博, 和田 淳

    日本内分泌学会雑誌   95 ( 2 )   747 - 747   2019年10月

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  • 原発性副甲状腺機能亢進症を合併した神経線維腫症1型の1例 査読

    小松原 基志, 稲垣 兼一, 森本 栄作, 藤澤 諭, 西山 悠紀, 原 孝行, 細谷 武史, 当真 貴志雄, 越智 可奈子, 大塚 文男, 和田 淳

    日本内分泌学会雑誌   95 ( 2 )   735 - 735   2019年10月

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  • 妊娠尿崩症をきたした経蝶形骨型髄膜瘤の一例 査読

    森本 栄作, 稲垣 兼一, 三好 智子, 西山 悠紀, 藤澤 諭, 小松原 基志, 原 孝行, 細谷 武史, 当真 貴志雄, 越智 可奈子, 大塚 文男, 和田 淳

    日本内分泌学会雑誌   95 ( 2 )   724 - 724   2019年10月

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  • 総合診療における血清プロラクチン値の性差と炎症性病態への関与

    山本 紘一郎, 花山 宜久, 安田 美帆, 長谷川 功, 原田 洸, 徳増 一樹, 萩谷 英大, 三好 智子, 小川 弘子, 小比賀 美香子, 大塚 文男

    日本内分泌学会雑誌   95 ( 2 )   769 - 769   2019年10月

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  • Feasibility of flow cytometric analysis of restricted light chain in endoscopic biopsy specimens from patients with gastrointestinal tract B cell lymphoma: a pilot study. 国際誌

    Matsueda A, Iwamuro M, Takahashi T, Omote S, Nishida K, Tanaka T, Ennishi D, Otsuka F

    BMC Res Notes.   12 ( 1 )   571 - 571   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s13104-019-4578-4

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  • A case of pseudo-pheochromocytoma possibly induced by a preceding respiratory infection.

    Hagiya H, Nakagami F, Yoshida S, Nagawasa M, Takami Y, Akasaka H, Yamamoto K, Otsuka F, Rakugi H

    J. Hosp. Gen. Med.   1 ( 3 )   16 - 20   2019年9月

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  • Myxedema coma accompanied by sick sinus syndrome and hypoventilation: a case report.

    Harada K, Murakami S, Tokumasu K, Togawa Y, Otsuka F

    J. Gen. Fam. Med.   20 ( 5 )   206 - 208   2019年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jgf2.267

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  • A novel case of myxoid variant of adrenocortical carcinoma in a patient with multiple endocrine neoplasia type 1.

    Harada K, Yasuda M, Hasegawa K, Yamazaki Y, Sasano H, Otsuka F

    Endocr. J.   66 ( 8 )   739 - 744   2019年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1507/endocrj.EJ19-0067

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  • FDG uptake in toxic multinodular goiter.

    Ocho K, Hasegawa K, Otsuka F

    J. Hosp. Gen. Med.   1 ( 2 )   14 - 15   2019年7月

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  • Factors Related to Burnout in Resident Physicians in Japan. 国際誌

    Nishimura Y, Miyoshi T, Obika M, Ogawa H, Kataoka H, Otsuka F

    Int. J. Med. Educ.   10   129 - 135   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.5116/ijme.5caf.53ad

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  • Surface related tunneling leakage in beta-Ga2O3 (001) vertical Schottky barrier diodes

    Ravikiran Lingaparthi, Kohei Sasaki, Quang Tu Thieu, Akio Takatsuka, Fumio Otsuka, Shigenobu Yamakoshi, Akito Kuramata

    APPLIED PHYSICS EXPRESS   12 ( 7 )   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IOP PUBLISHING LTD  

    beta-Ga2O3 (001) Schottky barrier diodes (SBDs) fabricated on a halide vapor phase epitaxy-grown epilayer showed anomalous reverse leakage characteristics, which could not be explained through thermionic field emission theory. A systematic investigation through the measurements and simulations of capacitance-voltage and current density-voltage characteristics suggested the presence of a thin surface layer on the epilayer with high density of oxygen vacancy states. This thin surface layer allowed the tunneling of electrons and caused anomalous reverse leakage properties (Thin surface barrier model). Annealing of the epilayer in an oxidative environment passivated the surface oxygen vacancy states and reduced the reverse leakage current enormously. (C) 2019 The Japan Society of Applied Physics

    DOI: 10.7567/1882-0786/ab2824

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  • Swollen hands and “fist sign” in acromegaly. 国際誌

    Harada K, Hasegawa K, Otsuka F

    Am. J. Med.   132 ( 7 )   e618-e619 - E619   2019年7月

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  • 岡山大学病院研修医メンター制度の実態調査

    佐藤 明香, 植田 真司, 宇賀 麻由, 矢野 修也, 小川 弘子, 三好 智子, 難波 志穂子, 大塚 文男

    医学教育   50 ( Suppl. )   187 - 187   2019年7月

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    記述言語:日本語   出版者・発行元:(一社)日本医学教育学会  

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  • A huge liver cyst manifesting dyspnea and edema.

    Nagao S, Iwamuro M, Shiraha H, Otsuka F

    Intern. Med.   58 ( 12 )   1811 - 1812   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.1957-18

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  • Histidine-Rich Glycoprotein Augments Natural Killer Cell Function by Modulating PD-1 Expression via CLEC-1B. 国際誌

    Nishimura Y, Wake H, Teshigawara K, Wang D, Sakaguchi M, Otsuka F, Nishibori M

    Pharmacol Res Perspect   7 ( 3 )   e00481 - e00481   2019年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/prp2.481

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  • Anterior Cutaneous Nerve Entrapment Syndrome Possibly Triggered by Oral Contraceptives.

    Omura D, Obika M, Iwamuro M, Nagao S, Nada T, Matsuzaki T, Kondo Y, Otsuka F

    Intern. Med   58 ( 10 )   1507 - 1509   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.1361-18

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  • Retention cysts due to latent pancreatic cancer.

    Oka K, Horiguchi S, Obika M, Otsuka F

    J. Hosp. Gen. Med.   ( 1 )   6 - 6   2019年5月

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  • Cardiac Computed Tomography of Aortic Infective Endocarditis.

    Harada K, Otsuka F

    QJM   112 ( 5 )   377 - 378   2019年5月

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  • Total Vascular Resistance and Augmentation Pressure in Patients with Peripheral Artery Disease

    Rika Takemoto, Haruhito A. Uchida, Nozomu Otaka, Yoshiko Hada, Yasuhiro Onishi, Natsumi Matsuoka, Shugo Okamoto, Mariko Nishiwaki, Hironobu Toda, Fumio Otsuka, Hiroshi Ito, Jun Wada

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   39   2019年5月

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    記述言語:英語   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • 総合内科診療における主訴と生化学データの関連 浸透圧マーカーに着目して

    大村 大輔, 佐藤 明香, 岡 浩介, 小川 弘子, 花山 宜久, 小比賀 美香子, 大塚 文男

    日本病院総合診療医学会雑誌   15 ( 3 )   175 - 175   2019年5月

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    記述言語:日本語   出版者・発行元:(一社)日本病院総合診療医学会  

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  • 膵酵素とアミノ酸製剤補充により改善した吸収不良症候群の1例

    山本 紘一郎, 中野 靖浩, 大村 大輔, 徳増 一樹, 長谷川 功, 堀口 繁, 花山 宜久, 小比賀 美香子, 小川 弘子, 大塚 文男

    日本病院総合診療医学会雑誌   15 ( 3 )   311 - 311   2019年5月

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    記述言語:日本語   出版者・発行元:(一社)日本病院総合診療医学会  

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  • Mesenteric Follicular Lymphoma. 国際誌

    Nishimura Y, Yamamoto A, Takahara M, Otsuka F

    Clin. Case Rep.   7 ( 5 )   1108 - 1109   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/ccr3.2148

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  • Septic pulmonary emboli caused by infected central venous port. 国際誌

    Harada K, Tokumasu K, Yasuda M, Otsuka F

    Postgrad. Med. J.   95 ( 1123 )   282 - 282   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/postgradmedj-2019-136461

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  • Diffuse vascular FDG uptake in late onset Takayasu arteritis. 国際誌

    Harada K, Hasegawa K, Otsuka F

    Am. J. Med.   132 ( 5 )   e560-e561 - E561   2019年5月

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  • Symptomatic Adrenal Myelolipoma.

    Omura D, Nakano Y, Takase R, Otsuka F

    Intern. Med   58 ( 8 )   1181 - 1181   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.1692-18

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  • Renal intravascular lymphoma diagnosed by FDG-PET.

    J. Hosp. Gen. Med.   2019年4月

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  • Axillary lymph node tuberculosis in the elderly.

    Ocho K, Tanimoto S, Shioji Y, Fujita K, Otsuka F

    J. Hosp. Gen. Med.   15   106 - 107   2019年4月

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  • FDG PET/CT findings in infected abdominal aortic aneurysm.

    Harada K, Fukushima F, Tokumasu K, Hagiya H, Otsuka F

    J. Hosp. Gen. Med.   1 ( 4 )   59 - 60   2019年4月

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  • Fever of unknown origin without increase of serum C-reactive protein in a patient with acute lymphoblastic leukemia/ lymphoblastic lymphoma.

    Oka K, Fujimura T, Horiguchi S, Yano T, Kondo E, Otsuka F

    J. Hosp. Gen. Med   1 ( 3 )   45 - 49   2019年4月

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  • Peripartum cardiomyopathy with marked pulmonary edema: A case report.

    Harada K, Otsuka F

    J. Hosp. Gen. Med.   1 ( 3 )   26 - 30   2019年4月

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  • Delayed postoperative hyponatremia after endoscopic transsphenoidal surgery for pituitary adenoma. 国際誌

    Tomita Y, Kurozumi K, Inagaki K, Kameda M, Ishida J, Yasuhara T, Ichikawa T, Sonoda T, Otsuka F, Date I

    Acta Neurochir (Wien)   161 ( 4 )   707 - 715   2019年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00701-019-03818-3

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  • 非機能性下垂体腺腫の術後に急速に肝障害を来した1例 査読

    越智 可奈子, 稲垣 兼一, 森本 栄作, 藤澤 諭, 小松原 基志, 原 孝行, 細谷 武史, 当真 貴志雄, 黒住 和彦, 和田 淳, 大塚 文男

    日本内分泌学会雑誌   95 ( 1 )   491 - 491   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • Orexinによる下垂体前葉ホルモン分泌への影響とBMP-4の関与 査読

    藤澤 諭, 小松原 基志, 森本 栄作, 西山 悠紀, 原 孝行, 細谷 武史, 当真 貴志雄, 越智 可奈子, 稲垣 兼一, 和田 淳, 大塚 文男

    日本内分泌学会雑誌   95 ( 1 )   490 - 490   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • インクレチンによるカテコラミン合成への影響 BMPとステロイドに着目して 査読

    小松原 基志, 西山 悠紀, 灘 隆宏, 岩田 菜穂子, 藤澤 諭, 原 孝行, 細谷 武史, 当真 貴志雄, 稲垣 兼一, 和田 淳, 大塚 文男

    日本内分泌学会雑誌   95 ( 1 )   423 - 423   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • カテコラミン産生に対するスクレロスチンの影響 PC12細胞を用いた検討 査読

    森本 栄作, 稲垣 兼一, 小松原 基志, 藤澤 諭, 西山 悠紀, 原 孝行, 細谷 武史, 当真 貴志雄, 越智 可奈子, 大塚 文男, 和田 淳

    日本内分泌学会雑誌   95 ( 1 )   423 - 423   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 卵巣顆粒膜細胞のステロイド合成におけるClock遺伝子とBMP-7の関与

    長尾 聡子, 岩田 菜穂子, 中野 靖浩, 灘 隆宏, 樫野 千明, 長谷川 徹, 大塚 文男

    日本内分泌学会雑誌   95 ( 1 )   504 - 504   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • グルココルチコイドによる卵胞ステロイド合成に与える影響とその機序の検討

    樫野 千明, 長谷川 徹, 中野 靖浩, 長尾 聡子, 岩田 菜穂子, 西山 悠紀, 細谷 武史, 鎌田 泰彦, 増山 寿, 大塚 文男

    日本内分泌学会雑誌   95 ( 1 )   500 - 500   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • アルドステロンによる卵胞ステロイド産生への影響とBMPの関与

    中野 靖浩, 長谷川 徹, 樫野 千明, 長尾 聡子, 灘 隆宏, 岩田 菜穂子, 西山 悠紀, 細谷 武史, 大塚 文男

    日本内分泌学会雑誌   95 ( 1 )   427 - 427   2019年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • Effects on postgraduate-year-I residents of simulation-based learning compared to traditional lecture-style education led by postgraduate-year-II residents. 国際誌

    Yamamoto A, Obika M, Mandai Y, Murakami T, Miyoshi T, Ino H, Kataoka H, Otsuka F

    BMC Medical Education   19 ( 1 )   87 - 87   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s12909-019-1509-y

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  • Ludwig's Angina and Mandibular Osteomyelitis after Dental Extraction.

    Yuki Otsuka, Ko Harada, Yoshito Nishimura, Fumio Otsuka

    JMA journal   2 ( 1 )   87 - 88   2019年3月

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  • Crowned Dens Syndrome Associated with hyperuricemia.

    Sugihara Y, Ogawa H, Otsuka F

    Intern. Med   58 ( 5 )   765 - 765   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.1589-18

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  • Orexin A modulates prolactin production by regulating BMP-4 activity in rat pituitary lactotorope cells. 国際誌

    Fujisawa S, Komatsubara M, Ogura-Ochi K, Tsukamoto-Yamauchi N, Toma K, Inagaki K, Wada J, Otsuka F

    Peptides   113   35 - 40   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.peptides.2019.01.002

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  • Runx3 regulates folliculogenesis and steroidogenesis in granulosa cells of immature mice. 査読 国際誌

    Ojima F, Saito Y, Tsuchiya Y, Ogoshi M, Fukamachi H, Inagaki K, Otsuka F, Takeuchi S , Takahashi S

    Cell Tissue Res.   375 ( 3 )   743 - 754   2019年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s00441-018-2947-2

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  • Interaction of ovarian steroidogenesis and clock gene expression modulated by bone morphogenetic protein-7 in human granulosa cells.

    Nagao S, Iwata N, Soejima Y, Takiguchi T, Aokage T, Kozato Y, Nakano Y, Nada T, Hasegawa T, Otsuka F

    Endocr. J.   66 ( 2 )   157 - 164   2019年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1507/endocrj.EJ18-0423

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  • Diagnostic FDG PET/CT findings in Polymyalgia Rheumatica.

    Otsuka Y, Harada K, Otsuka F

    QJM: An International Journal of Medicine   112 ( 2 )   139 - 140   2019年2月

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  • Auricle pain due to tophi.

    Nakano Y, Otsuka F

    Intern. Med   58 ( 3 )   453 - 453   2019年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.1293-18

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  • Comparison of Two Electrosurgical Modes for Endoscopic Submucosal Dissection of Superficial Colorectal Neoplasms: A Prospective Randomized Study.

    Sugihara Y, Harada K, Oka S, Yasutomi E, Yamasaki Y, Inokuchi T, Kinugasa H, Takahara M, Hiraoka S, Otsuka F, Okada H

    Acta Med. Okayama   73 ( 1 )   81 - 84   2019年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18926/AMO/56463

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  • A Remarkable Uptake of FDG in Huge Mediastinal Hashimoto' s Goiter.

    Oka K, Hosoya T, Taira N and Otsuka F

    Intern. Med   58 ( 2 )   313 - 314   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.0898-18

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  • A Case of Juvenile Hypertension Suggestive of Adrenomedullary Hyperplasia.

    Nishimura Y, Yasuda M, Hasegawa K, Otsuka F

    Intern. Med   58 ( 2 )   311 - 311   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.1182-18

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  • Hyperthyroidism with selective immunoglobulin A deficiency.

    Harada K, Otsuka F

    Intern. Med   58 ( 1 )   145 - 146   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.1215-18

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  • Actinomycosis-induced trismus with orbital involvement.

    Omura D, Rai K, Kusano N, Otsuka F

    Intern. Med   58 ( 1 )   153 - 154   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.1320-18

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  • Pleomorphic parotid adenoma with Graves’hyperthyroidism.

    Ogura-Ochi K, Otsuka F

    J. Hosp. Gen. Med.   15   26 - 27   2019年1月

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  • A huge goiter involved in Marine-Lenhart syndrome.

    Oka K, Yasuda M, Shien T and Otsuka F

    J Gen Fam Med   20 ( 1 )   37 - 38   2019年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jgf2.220

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  • Cognitive Decline due to Ectopic Primary Hyperparathyroidism 国際誌

    Nishimura Y, Yamamoto A, Takahara M & Otsuka F

    Clin. Case Rep   6 ( 12 )   2513 - 2514   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/ccr3.1901

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  • Orexinのプロラクチン産生への影響とBMP-4の関与 査読

    藤澤 諭, 小松原 基志, 山内 尚子, 西山 悠紀, 原 孝行, 細谷 武史, 当真 貴志雄, 稲垣 兼一, 和田 淳, 大塚 文男

    日本内分泌学会雑誌   94 ( 4 )   1328 - 1328   2018年12月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 出血により高PRL血症を呈した胸髄海綿状血管腫の1例 査読

    森本 栄作, 稲垣 兼一, 原 孝行, 藤澤 諭, 越智 可奈子, 三好 智子, 大塚 文男, 和田 淳

    日本内分泌学会雑誌   94 ( 3 )   1036 - 1036   2018年12月

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  • Changes in serum biochemical markers in relation to chief complaints and aging in general medicine

    Omura D, Sato A, Oka K, Hanayama Y, Ogawa H, Obika M and Otsuka F

    Acta Med. Okayama   72 ( 6 )   553 - 562   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18926/AMO/56372

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  • アルドステロンとBMPによる卵胞プロゲステロン産生への影響とその機序

    中野 靖浩, 長谷川 徹, 長尾 聡子, 灘 隆宏, 岩田 菜穂子, 西山 悠紀, 細谷 武史, 大塚 文男

    日本内分泌学会雑誌   94 ( 4 )   1439 - 1439   2018年12月

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  • メトホルミンとBMPによる卵胞ステロイド合成系への影響とその機序

    岩田 菜穂子, 長谷川 徹, 藤田 志帆, 長尾 聡子, 中野 靖浩, 灘 隆宏, 西山 悠紀, 細谷 武史, 大塚 文男

    日本内分泌学会雑誌   94 ( 4 )   1438 - 1438   2018年12月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 卵胞ステロイド合成における時計遺伝子とBMPの関与 ヒト顆粒膜細胞を用いた検討

    長尾 聡子, 岩田 菜穂子, 副島 佳晃, 滝口 隆章, 青景 珠実, 上里 祐賀, 中野 靖浩, 灘 隆宏, 長谷川 徹, 大塚 文男

    日本内分泌学会雑誌   94 ( 4 )   1434 - 1434   2018年12月

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  • 顆粒膜細胞における時計遺伝子とBMPによる卵胞ステロイド合成調節

    長尾 聡子, 岩田 菜穂子, 副島 佳晃, 滝口 隆章, 青影 珠実, 上里 祐賀, 中野 靖浩, 灘 隆宏, 長谷川 徹, 大塚 文男

    日本内分泌学会雑誌   94 ( 4 )   1394 - 1394   2018年12月

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  • A Case of Diffuse Esophageal Spasm Treated with Peroral Endoscopic Myotomy

    Sugihara Y, Harada K, Kato R, Yamauchi K, Sakae H, Kawano S, Hiraoka S , Kawahara Y, Otsuka F, Okada H

    Acta Med Okayama   72 ( 6 )   595 - 600   2018年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18926/AMO/56378

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  • Clival osteomyelitis with cavernous sinus thrombosis due to Fusobacterium nucleatum and Campylobacter rectus induced by tooth extraction

    Oka K, Nakano Y, Sazumi Y, Michitani T, Horiguchi S, Ocho K, Iwamuro M and Otsuka F

    Intern. Med   57 ( 22 )   3325 - 3328   2018年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.1025-18

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  • Clinical relevance of low androgen to gastroesophageal reflux symptoms

    Harada K, Hanayama Y, Yasuda M, Hasegawa K, Obika M, Kataoka H, Itoshima K, Okada K and Otsuka F

    Endocr. J   65 ( 10 )   1039 - 1047   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1507/endocrj.EJ18-0187

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  • Photophobia in a patient with Hashimoto’s thyroiditis

    Nishimura Y and Otsuka F

    Intern. Med   57 ( 19 )   2919 - 2920   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.0178-17

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  • Clinical characteristics of febrile outpatients: Possible involvement of thyroid dysfunction in febrile tachycardia

    Oka K, Hanayama Y, Sato A, Omura D, Yasuda M, Hasegawa K, Obika M and Otsuka F

    Acta Med. Okayama   72 ( 5 )   447 - 456   2018年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18926/AMO/56242

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  • The Esophagus on Sight: Ultrasonography in Achalasia.

    Yoshito Nishimura, Yuusaku Sugihara, Fumio Otsuka

    JMA journal   1 ( 1 )   71 - 72   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.31662/jmaj.2018-0023

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  • Effect of the interaction of metformin and bone morphogenetic proteins on ovarian steroidogenesis by human granulosa cells 国際誌

    Iwata N, Hasegawa T, Fujita S, Nagao S, Nakano Y, Nada T, Nishiyama Y, Hosoya T and Otsuka F

    Biochem. Biopys. Res. Commun   503 ( 3 )   1422 - 1427   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bbrc.2018.07.058

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  • Enterovaginal and colovesical fistulas as late complications of pelvic radiotherapy

    Iwamuro M, Hasegawa K, Hanayama Y, Kataoka H, Tanaka T, Kondo Y, Otsuka F

    J. Gen. Fam. Med   19 ( 5 )   166 - 169   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jgf2.184

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  • 超音波検査にて経時的変化の観察が可能であった巨細胞性動脈炎の2症例

    武本 梨佳, 内田 治仁, 戸田 洋伸, 竹内 英実, 大高 望, 大塚 寛昭, 大塚 文男, 伊藤 浩, 和田 淳

    脈管学   58 ( Suppl. )   S211 - S211   2018年9月

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    記述言語:日本語   出版者・発行元:(一社)日本脈管学会  

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  • Thyroid Follicular Carcinoma in a Teenager: A Case Report

    Oka K, Shien T and Otsuka F

    J. Gen. Fam. Med   19 ( 5 )   170 - 172   2018年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jgf2.185

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  • オレキシンによるBMPシグナルの抑制と卵胞プロゲステロン産生への影響

    藤田 志保, 長谷川 徹, 西山 悠紀, 藤澤 諭, 細谷 武史, 中野 靖浩, 岩田 菜穂子, 鎌田 泰彦, 増山 寿, 大塚 文男

    日本生殖医学会雑誌   63 ( 3 )   309 - 309   2018年8月

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    記述言語:日本語   出版者・発行元:(一社)日本生殖医学会  

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  • Manifestation of central diabetes insipidus in a patient with thyroid storm

    Nakamichi A, Ocho K, Oka K, Yasuda M, Hasegawa K, Iwamuro M, Obika M, Rai K and Otsuka F

    Intern. Med   57 ( 13 )   1939 - 1942   2018年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.0063-17

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  • Interaction between orexin A and bone morphogenetic protein system on progesterone biosynthesis by rat granulosa cells 国際誌

    Fujita S, Hasegawa T, Nishiyama Y, Fujisawa S, Nakano Y, Nada T, Iwata N, Kamada Y, Masuyama H and Otsuka F

    J. Steroid Biochem. Mol. Biol   181   73 - 79   2018年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jsbmb.2018.03.004

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  • Modulation of bone morphogenetic protein activity by melatonin in ovarian steroidogenesis.

    Fumio Otsuka

    Reproductive medicine and biology   17 ( 3 )   228 - 233   2018年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:WILEY  

    Background: Melatonin regulates circadian and seasonal rhythms and the activities of hormones and cytokines that are expressed in various tissues, including the ovary, in which melatonin receptors are expressed. In the ovary, follicular growth occurs as a result of complex interactions between pituitary gonadotropins and autocrine and paracrine factors, including bone morphogenetic proteins (BMPs) that are expressed in the ovary. Methods: The effects of melatonin and BMPs on steroidogenesis were examined by using the primary cultures of rat granulosa cells. Main findings Results: It was shown that melatonin has antagonistic effects on BMP-6 actions in the granulosa cells, suggesting that melatonin is likely to contribute to balancing the biological activity of endogenous BMPs that maintain progesterone production and luteinization in the growing follicles. Similar interactions between melatonin and BMP-smad signaling also were shown in the mechanism of controlling ovarian steroidogenesis by other ligands. Conclusion: A new role of melatonin in the regulation of endocrine homeostasis in relation to BMP activity is introduced in this review.

    DOI: 10.1002/rmb2.12089

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  • Isolated follicle-stimulating hormone deficiency coincidentally diagnosed by hematospermia

    Fujisawa S and Otsuka F

    Intern. Med   57 ( 12 )   1799 - 1799   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.9693-17

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  • Unilateral exophthalmos due to lymphomatous involvement

    Yasuda M, M Iwamuro, Kimura K and Otsuka F

    Intern. Med   57 ( 9 )   1335 - 1335   2018年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.8900-17

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  • A case of chemical meningitis due to transsphenoidal surgery for craniopharyngioma

    Hasegawa K, Yasuda M, Miyoshi T, Ogawa H, Obika M, Kurozumi K, Otsuka F, et al.

    ACTH related peptides   29   16 - 18   2018年4月

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  • Incretins modulate progesterone biosynthesis by regulating bone morphogenetic protein activity in rat granulosa cells 国際誌

    Nishiyama Y,Hasegawa T, Fujita S, Iwata N, Nagao S, Hosoya T, Inagaki K, Wada Jun and Otsuka F

    J. Steroid Biochem. Mol. Biol   178   82 - 88   2018年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jsbmb.2017.11.004

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  • RS3PE syndrome mimicking venous thrombosis

    Nakano Y, Oka K, Horiguchi S and Otsuka F

    J. Hosp. Gen. Med   14 ( 3 )   223 - 224   2018年4月

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  • Colonoscopy examination requires a longer time in patients with acromegaly than in other individuals

    Iwamuro M, Yasuda M, Hasegawa K, Fujisawa S, Ogura-Ochi K, Sugihara Y, Harada K, Hiraoka S, Okada H and Otsuka F

    Endocr. J   65 ( 2 )   151 - 157   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1507/endocrj.EJ17-0322

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  • Far East scarlet-like fever masquerading as adult-onset Kawasaki disease

    Ocho K, Iwamuro M, Hasegawa K, Hagiya H, Rai K, Yumoto T, Otsuka F

    Intern. Med   57 ( 3 )   437 - 440   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.9250-17

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  • Severe Gastritis after Administration of Nivolumab and Ipilimumab

    Nishimura Y, Yasuda M, Ocho K, Iwamuro M, Yamasaki O, Tanaka T, Otsuka F

    Case Rep Oncol   11 ( 2 )   549 - 556   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1159/000491862

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  • Interaction of Melatonin and BMP-6 in Ovarian Steroidogenesis. 国際誌

    Fumio Otsuka

    Vitamins and hormones   107   137 - 153   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER ACADEMIC PRESS INC  

    The bone morphogenetic protein (BMP) system in the ovary plays a physiological role as a luteinization inhibitor in growing follicles. BMP-6 secreted from oocytes and granulosa cells can exert an inhibitory effect on follicle-stimulating hormone (FSH) actions by suppressing adenylate cyclase activity downstream of the FSH receptor. The inhibition of FSH-induced progesterone production by BMP-6 is impaired by melatonin treatment in granulosa cells. Intracellular Smad signaling induced by BMP-6 is suppressed by melatonin, suggesting that melatonin has a regulatory role in BMP receptor signaling in granulosa cells. Since the expression of BMP-6 in granulosa cells is increased in patients with polycystic ovary syndrome, melatonin may play an important role in the maintenance of progesterone production by suppressing BMP-6 signaling, leading to the preservation of ovarian function.

    DOI: 10.1016/bs.vh.2018.01.012

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  • Psoas abscess secondary to paravertebral inflammation 国際誌

    Nishimura Y, Otsuka F

    ID Cases   13   e00435   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.idcr.2018.e00435

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  • Diffuse intestinal ganglioneuromatosis showing multiple large bowel ulcers in a patient with neurofibromatosis type 1. 査読

    Iwamuro M, Omote R, Tanaka T, Sunada N, Nada T, Kondo Y, Nose S, Kawaguchi M, Otsuka F, Okada H

    Intern. Med   56 ( 24 )   3287 - 3291   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.8671-16

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  • Rapid laboratory tests for Malaria detection in Japan.

    Kashihara N, Iwamuro M, Kusano N, Otsuka F

    J. Gen. Fam. Med   18 ( 6 )   470 - 471   2017年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/jgf2.119

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  • Pulmonary Intravascular Lymphoma Detected by FDG-PET.

    Nada T, Iwamuro M, Kimura K, Otsuka F

    J. Gen. Fam. Med   18 ( 6 )   477 - 478   2017年12月

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    Oka K, Iwamuro M, Otsuka F

    J. Gen. Fam. Med   18 ( 6 )   473 - 474   2017年12月

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  • Hypersensitivity Pneumonitis Caused by a Home Ultrasonic Humidifier Contaminated with Candida guilliermondii.

    Ando A, Hagiya H, Nada T, Kimura K, Waseda K, Rai K, Hanayama Y, Otsuka F

    Intern. Med   56 ( 22 )   3109 - 3112   2017年11月

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  • Regulation of gonadotropins by urocortin 2 in gonadotropic tumor L?T2 cells. 国際誌

    Kageyama K, Murasawa S, Niioka K, Otsuka F, Yagi H, Daimon M

    Neuroscience Letters   660   63 - 67   2017年11月

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  • Reply to “The Difficulty in Administering Appropriate Antimicrobial Therapy for Stenotrophomonas maltophilia Bacteremia”

    Ebara H, Hagiya H, Haruki Y, Kondo E, Otsuka F

    Intern. Med   56 ( 20 )   2817 - 2817   2017年10月

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    Harada K, Kashihara N, Iwamuro M, Otsuka F

    J. Gen. Fam. Med   18 ( 5 )   301 - 302   2017年10月

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  • Perimandibular abscess associated with bisphosphonate-related osteonecrosis of the jaw. 査読

    Ocho K, Iwamuro M, Hagiya H, Ibaragi S, Otsuka F

    J. Gen. Fam. Med   18 ( 5 )   305 - 306   2017年10月

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  • Clinical and hormonal characteristics of primary adrenal lymphomas: Necessity for early detection of adrenal insufficiency. 査読

    Harada K, Kimura K, Iwamuro M, Terasaka T, Hanayama Y, Kondo E, Hayashi E, Yoshino T, Otsuka F

    Intern. Med   56 ( 17 )   2261 - 2269   2017年9月

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  • A regulatory role of androgen in ovarian steroidogenesis by rat granulosa cells. 国際誌

    Hasegawa T, Kamada Y, Hosoya T, Fujita S, Nishiyama Y, Iwata N, Hiramatsu Y, Otsuka F

    J. Steroid Biochem. Mol. Biol   172   160 - 165   2017年9月

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    DOI: 10.1016/j.jsbmb.2017.07.002

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  • Regulatory role of melatonin and BMP-4 in prolactin production by rat pituitary lactotrope GH3 cells. 査読 国際誌

    Ogura-Ochi K, Fujisawa S, Iwata N, Komatsubara M, Nishiyama Y, Tsukamoto-Yamauchi N, Inagaki K, Wada J, Otsuka F

    Peptides   94   19 - 24   2017年8月

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    DOI: 10.1016/j.peptides.2017.06.001

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  • 顕性クッシングを呈しメチラポンで加療中のAIMAHの2例

    藤澤 諭、稲垣兼一、西山悠紀、小松原基志、原 孝行、細谷武史、当真貴志雄、越智可奈子、和田 淳、大塚文男

    日本内分泌学会雑誌   93   44 - 45   2017年6月

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  • Predictors of vasovagal reactions during preoperative autologous blood donation: A single-institution analysis.

    Nishimori H, Fujii N, Fujii K, Ikeda T, Asano N, Ogo H, Yamakawa M, Takagi N, Otsuka F, Ikeda K

    Int. J. Hematol   105 ( 6 )   812 - 818   2017年6月

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  • Successful treatment with glucocorticoid for secondary Fanconi syndrome caused by sarcoidosis 査読 国際誌

    Omura D, Hagiya H, Hanayama Y, Hasegawa K, Morinaga H, Kikuta A, Kataoka H, Otsuka F.

    Mod Rheumatol   27 ( 3 )   545 - 547   2017年5月

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  • 両側上腕血圧測定不能を契機に発見された巨細胞性動脈炎の1例 査読

    武本 梨佳, 内田 治仁, 戸田 洋伸, 江尻 健太郎, 竹内 英実, 垣尾 勇樹, 奥山 由加, 岡田 健, 大塚 文男, 伊藤 浩, 和田 淳

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   6回   177 - 177   2017年5月

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  • A unique acromegalic osteoarthropathy: Manubriosternal joint arthritis. 国際誌

    Fujisawa S, Otsuka F

    Clin. Case Rep   5 ( 5 )   725 - 726   2017年5月

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  • Endoscopic Manifestations and Clinical Characteristics of Cytomegalovirus Infection in the Upper Gastrointestinal Tract.

    Iwamuro M, Kondo E, Tanaka T, Hagiya H, Kawano S, Kawahara Y, Otsuka F, Okada H

    Acta Medica Okayama   71 ( 2 )   97 - 104   2017年4月

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    DOI: 10.18926/AMO/54977

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  • Idiopathic adult ileo-colonic intussusception.

    Iwamuro M, Nada T, Kimura K, Hanayama Y, Otsuka F

    J. Gen. Fam. Med   18 ( 2 )   94 - 95   2017年4月

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    DOI: 10.1002/jgf2.68

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  • Lanthanum Deposition in the Stomach: Usefulness of Scanning Electron Microscopy for Its Detection.

    Iwamuro M, Urata H, Tanaka T, Ando A, Nada T, Kimura K, Yamauchi K, Kusumoto C, Otsuka F, Okada H

    Acta Medica Okayama   71 ( 1 )   73 - 78   2017年2月

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    DOI: 10.18926/AMO/54828

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  • Combined effects of androgen and growth hormone on osteoblast marker expression in mouse C2C12 and MC3T3-E1 cells induced by bone morphogenetic protein. 査読 国際誌

    Kimura K, Terasaka T, Iwata N, Katsuyama T, Komatsubara M, Nagao R, Inagaki K, Otsuka F

    J Clin Med   6 ( 1 )   2017年1月

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    DOI: 10.3390/jcm6010006

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  • Melatonin regulates catecholamine biosynthesis by modulating bone morphogenetic protein and glucocorticoid actions. 査読 国際誌

    Komatsubara M, Hara T, Hosoya T, Toma K, Tsukamoto-Yamauchi N, Iwata N, Inagaki K, Wada J, Otsuka F

    J. Steroid Biochem. Mol. Biol   165 ( Pt B )   182 - 189   2017年1月

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    DOI: 10.1016/j.jsbmb.2016.06.002

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  • Clinical Characteristics of Stenotrophomonas maltophilia Bacteremia: A Regional Report and A Review of Japanese Case Series.

    Ebara H, Hagiya H, Haruki Y, Kondo E, Otsuka F

    Intern. Med   56 ( 2 )   137 - 142   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.56.6141

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  • Paroxysmal hypertension induced by an insulinoma. 査読

    Harada K, Hanayama Y, Hasegawa K, Iwamuro M, Hagiya H, Yoshida R, Otsuka F

    Intern. Med.   56 ( 4 )   413 - 417   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.56.7758

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  • 脳梗塞を発症した、頸動脈・腎動脈狭窄症を呈した若年男性の1例 査読

    武本 梨佳, 内田 治仁, 戸田 洋伸, 竹内 麻梨, 中村 知子, 戸田 由香, 渡辺 修久, 江尻 健太郎, 麻植 浩樹, 岡田 健, 大塚 文男, 伊藤 浩

    超音波検査技術   41 ( 5 )   584 - 584   2016年10月

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    記述言語:日本語   出版者・発行元:(一社)日本超音波検査学会  

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  • A rare case of diffuse large B-cell lymphoma in a patient with IgG4-related autoimmune pancreatitis 査読

    Yoshito Nishimura,Masaya Iwamuro*,Kazuki Ocho,Kou Hasegawa,Kosuke Kimura*,Yoshihisa Hanayama*,Eisei Kondo*,Takehiro Tanaka*,Fumio Otsuka*

    Acta Medica Okayama, Acta. Medica Okayama, Acta medicinae Okayama, Acta medica Okayama   70 ( 4 )   279 - 83   2016年8月

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  • Increased serum KL-6 levels induced by pulmonary mycobacterium avium complex infection in a patient with RA-associated lung disease 査読

    Koichi Waseda*,Kazuki Ocho,Kou Hasegawa,Kosuke Kimura*,Masaya Iwamuro*,Yoshihisa Hanayama*,Eisei Kondo*,Nobuaki Miyahara*,Fumio Otsuka*

    Acta Medica Okayama, Acta. Medica Okayama, Acta medicinae Okayama, Acta medica Okayama   70 ( 3 )   217 - 221   2016年6月

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  • A case of an adrenocorticotropic hormone-producing pituitary adenoma removed via electromagnetic-guided neuroendoscopy 査読

    Yusuke Tomita ,Kazuhiko Kurozumi, Tomohiro Terasaka, Kenichi Inagaki, Fumio Otsuka, Isao Date

    Neurological Surgery   44 ( 6 )   473 - 9   2016年6月

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    DOI: 10.11477/mf.1436203313

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  • 右総頸動脈に収縮期に逆行性血流を呈した腕頭動脈閉塞の1例 査読

    武本 梨佳, 戸田 洋伸, 戸田 由香, 勢井 麻梨, 中村 知子, 渡辺 修久, 江尻 健太郎, 麻植 浩樹, 杉生 憲志, 岡田 健, 大塚 文男, 伊藤 浩

    超音波検査技術   41 ( Suppl. )   S230 - S230   2016年6月

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  • Antiobesity action of ACAM by modulating the dynamics of cell adhesion and actin polymerization in adipocytes 査読 国際誌

    Kazutoshi Murakami,Jun Eguchi*,Kazuyuki Hida,Atsuko Nakatsuka*,Akihiro Katayama,Miwa Sakurai,Haruki Choshi,Masumi Furutani,Daisuke Ogawa,Kohji Takei*,Fumio Otsuka*,Jun Wada*

    Diabetes   65 ( 5 )   1255 - 67   2016年5月

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    DOI: 10.2337/db15-1304

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  • レボドパと酸化マグネシウムの同時内服で黒色痰・黒色尿を呈した1例 査読

    岩室 雅也、灘 隆宏、大塚文男

    内科   117 ( 2 )   2016年2月

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  • BMP-6 modulates somatostatin effects on luteinizing hormone production by gonadrotrope cells 査読 国際誌

    Kishio Toma*,Fumio Otsuka*,Kohei Oguni,Tomohiro Terasaka,Motoshi Komatsubara,Naoko Tsukamoto-Yamauchi*,Kenichi Inagaki*,Hirofumi Makino

    Peptides   76   96 - 101   2016年2月

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.peptides.2016.01.011

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  • Eagle症候群の1例 査読

    岩室 雅也、小牧稔幸、大塚文男

    内科   117 ( 2 )   2016年1月

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  • Emergence of daptomycin-resistant Staphylococcus aureus during treatment 査読

    Hideharu Hagiya,Yuto Haruki,Taeko Uchida,Tomoko Wada,Sumiko Shiota,Tomoharu Ishida,Hiroko Ogawa*,Tomoko Murase,Fumio Otsuka*

    Internal Medicine, Japanese Journal of Medicine   55 ( 1 )   73 - 8   2016年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • White Feces Caused by the Administration of a Somatostatin Analogue. 査読

    Iwamuro M, Terasaka T, Otsuka F, Okada H

    Internal medicine (Tokyo, Japan)   55 ( 13 )   1817 - 1817   2016年

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  • Invasive Intrasellar Plasmacytoma Mimicking Pituitary Adenoma. 査読

    Terasaka T, Inagaki K, Otsuka F

    Internal medicine (Tokyo, Japan)   55 ( 11 )   1501 - 1502   2016年

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    DOI: 10.2169/internalmedicine.55.6414

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  • Reactivation of human herpes virus-6 in the renal tissue of a patient with drug-induced hypersensitivity syndrome/drug rash with eosinophilia and systemic symptoms (DIHS/DRESS) 査読

    Hideharu Hagiya,Masaya Iwamuro*,Takehiro Tanaka*,Kou Hasegawa,Yoshihisa Hanayama*,Maya Kimura,Fumio Otsuka*

    Internal Medicine, Japanese Journal of Medicine   55 ( 13 )   1769 - 74   2016年

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    DOI: 10.2169/internalmedicine.55.6287

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  • An uncommon manifestation of fitz-hugh-curtis syndrome with right-side chest pain 査読

    Ko Harada,Masaya Iwamuro*,Yoshihisa Hanayama*,Fumio Otsuka*

    Acta Medica Okayama, Acta. Medica Okayama, Acta medicinae Okayama, Acta medica Okayama   70 ( 2 )   145 - 9   2016年

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  • Detection of minute duodenal follicular lymphoma lesions using magnifying endoscopy 査読

    Masaya Iwamuro*,Eisei Kondo*,Fumio Otsuka*,Katsuyoshi Takata,Tadashi Yoshino*,Yoshiro Kawahara*,Hiroyuki Okada*

    Acta Medica Okayama, Acta. Medica Okayama, Acta medicinae Okayama, Acta medica Okayama   70 ( 2 )   139 - 44   2016年

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  • Endoscopic detection of the gastric lesions of peripheral T-cell lymphoma 査読 国際誌

    Masaya Iwamuro*,Kosuke Kimura*,Eisei Kondo*,Takahiro Nada,Eri Nakamura,Katsuyoshi Takata,Takehiro Tanaka*,Fumio Otsuka*,Tadashi Yoshino*,Hiroyuki Okada*

    ecancermedicalscience   10   625 - 625   2016年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.3332/ecancer.2016.625

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  • Hypoparathyroidism solely manifesting otological symptoms 査読

    Tokiko Urabe,Hideharu Hagiya,Eri Nakamura,Fumio Otsuka*

    Internal Medicine, Japanese Journal of Medicine   55 ( 2 )   211 - 2   2016年

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    担当区分:筆頭著者   記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.55.5347

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  • Pheochromocytoma Manifesting Persistent Right Shoulder Pain and Hypochondralgia 査読

    Hagiya H, Nakamura E, Terasaka T, Hasegawa K, Asano K, Nada T, Kimura K, Waseda K, Hanayama Y and Otsuka F

    J. General Family Med   16 ( 4 )   292 - 296   2015年12月

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    DOI: 10.14442/jgfm.16.4_292

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  • Refractory chyluria due to filariasis 査読 国際誌

    Hagiya H, Otsuka F

    Infection   43 ( 6 )   785 - 6   2015年12月

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    DOI: 10.1007/s15010-015-0804-8

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  • Regulatory effects of fibroblast growth factor-8 and tumor necrosis factor-α on osteoblast marker expression induced by bone morphogenetic protein-2. 査読 国際誌

    Katsuyama T, Otsuka F, Terasaka T, Inagaki K, Takano-Narazaki M, Matsumoto Y, Sada KE, Makino H

    Peptides   73   88 - 94   2015年11月

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    DOI: 10.1016/j.peptides.2015.09.007

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  • Superior ophthalmic vein thrombosis associated with severe facial trauma: a case report 査読 国際誌

    Mishima M, Yumoto T, Hashimoto H, Yasuhara T, Iida A, Tsukahara K, Sato K, Ugawa T, Otsuka F and Ujike Y

    J. Med. Case Rep   9   244 - 244   2015年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/s13256-015-0737-y

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  • 脳梗塞を発症した、頸動脈狭窄症及び腎動脈狭窄症を呈した若年男性の1例 査読

    武本 梨佳, 内田 治仁, 戸田 洋伸, 勢井 麻梨, 中村 知子, 戸田 由香, 江尻 健太郎, 麻植 浩樹, 岡田 健, 大塚 文男, 伊藤 浩

    脈管学   55 ( Suppl. )   S246 - S246   2015年10月

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  • 肺tumorletによる異所性ACTH症候群の1例

    当真 貴志雄, 稲垣 兼一, 原 孝行, 越智 可奈子, 小松原 基志, 細谷 武史, 山内 尚子, 三好 智子, 和田 淳, 大塚 文男

    日本内分泌学会雑誌   91 ( 3 )   827 - 827   2015年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • Mutual effects of melatonin and activin on induction of aldosterone production by human adrenocortical cells. 査読 国際誌

    Hara T, Otsuka F, Tsukamoto-Yamauchi N, Inagaki K, Hosoya T, Nakamura E, Terasaka T, Komatsubara M, Makino H

    J Steroid Biochem Mol Biol   152   8 - 15   2015年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jsbmb.2015.04.012

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  • A Rare Cause of Esophageal Ulcers 査読 国際誌

    Iwamuro M, Tsuzuki T, Otsuka F

    Gastroenterology   149 ( 1 )   31 - 2   2015年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • 高血圧を契機に発見されたインスリノーマの1例

    花山 宜久, 池上 良一, 長谷川 功, 萩谷 英大, 浅野 喜久子, 灘 隆宏, 村上 和敏, 早稲田 公一, 片岡 仁美, 吉田 龍一, 大塚 文男

    日本病院総合診療医学会雑誌   8 ( 2 )   97 - 97   2015年6月

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  • 細菌性眼内炎を契機に発見された侵襲性肺炎球菌感染症の2例

    木村 耕介, 萩谷 英大, 長谷川 功, 灘 隆宏, 中村 絵里, 早稲田 公一, 花山 宜久, 村上 和敏, 近藤 英生, 大塚 文男

    日本病院総合診療医学会雑誌   8 ( 2 )   106 - 107   2015年6月

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  • Atypical onset of eosinophilic granulomatosis with polyangitis in a patient with long-term well-controlled bronchial asthma 査読

    Akao S, Hagiya H, Hasegawa K, Nada T, Nakamura E, Kimura K, Waseda K, Hanayama Y, Deguchi K, Otsuka F

    General Medicine   16 ( 2 )   99 - 102   2015年6月

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  • Gastric pseudopolyposis formed after recovery from gastric gangrene 査読 国際誌

    Iwamuro M, Hanayama Y, Otsuka F, Okada H.

    Dig Liver Dis   47 ( 6 )   e9 - E9   2015年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.dld.2014.12.016

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  • ICU管理が必要となったmulticentric Castleman disease(MCD)/TAFRO症候群(2)

    木村 耕介, 近藤 英生, 松岡 賢市, 灘 隆弘, 中村 絵里, 岩室 雅也, 浅野 喜久子, 長谷川 巧, 萩谷 英大, 早稲田 公一, 花山 宜久, 村上 和敏, 飯田 淳義, 塚原 紘平, 鵜川 豊世武, 谷本 光音, 吉野 正, 大塚 文男

    日本リンパ網内系学会会誌   55   115 - 115   2015年6月

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    記述言語:日本語   出版者・発行元:(一社)日本リンパ網内系学会  

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  • 視野障害で発生し大脳白質病変を伴った下垂体腫大の1例

    中村 絵里, 灘 隆宏, 岡野 美咲, 木村 耕介, 長谷川 功, 花山 宜久, 黒住 和彦, 大塚 文男

    日本内分泌学会雑誌   91 ( 1 )   377 - 377   2015年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 血中と尿・唾液中のコルチゾール値に乖離を認めた副腎サブクリニカルクッシングの1例

    長谷川 功, 中村 絵里, 萩谷 英大, 花山 宜久, 蔭山 和則, 大塚 文男

    日本内分泌学会雑誌   91 ( 1 )   294 - 294   2015年4月

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  • Complication of chronic eosinophilic pneumonia in an elderly patient with Sjoegren syndrome 査読

    Waseda K, Hagiya H, Hanayama Y, Terasaka T, Kimura K, Tsuzuki T, Hasegawa K, Nada T, Nakamura E, Murakami K, Kondo E, Otsuka F.

    Acta Med Okayama   69 ( 2 )   123 - 7   2015年4月

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  • Interaction of pituitary hormones and expression of clock genes modulated by bone morphogenetic protein-4 and melatonin 査読 国際誌

    Tsukamoto-Yamauchi N, Terasaka T, Iwasaki Y, Otsuka F

    Biochem Biophys Res Commun   459 ( 1 )   172 - 7   2015年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bbrc.2015.02.100

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  • Regulatory role of BMP-9 in steroidogenesis by rat ovarian granulosa cells 査読 国際誌

    Hosoya T, Otsuka F, Nakamura E, Terasaka T, Inagaki K, Tsukamoto-Yamauchi N, Hara T, Toma K, Komatsubara M, Makino H

    J Steroid Biochem Mol Biol   147   85 - 91   2015年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jsbmb.2014.12.007

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  • Lemierre syndrome involving external jugular vein 査読 国際誌

    Hagiya H, Haruki Y, Otsuka F

    Acute Medicine & Surgery   2 ( 1 )   64 - 68   2015年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/ams2.61

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  • Disseminated streptococcal endophthalmitis in two diabetic patients 査読

    Hagiya H, Aoki K, Tateda K, Otsuka F

    Intern Med   54 ( 10 )   1317 - 8   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.54.4134

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  • A paraganglioma in a hypertensive patient with unilateral renal hypoplasia 査読

    Terasaka T, Hagiya H, Kimura K, Nada T, Nakamura E, Hanayama Y, Sugiyama H, Kobayashi Y, Yanai H, Otsuka F.

    Acta Med Okayama   69 ( 2 )   119 - 22   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.18926/AMO/53341

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  • Insulinoma discovered in diffusely calcified chronic pancreatitis 査読

    Terasaka T, Tsukamoto K, Inagaki K, Otsuka F

    Intern Med   54 ( 21 )   2785 - 6   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.54.5049

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  • Myopathy and eosinophilic pneumonia coincidentally induced by treatment with daptomycin. 査読

    Hagiya H, Hasegawa K, Asano K, Terasaka T, Kimura K, Nada T, Nakamura E, Waseda K, Hanayama Y, Otsuka F

    Intern Med   54 ( 5 )   525 - 9   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.54.3397

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  • Hyperintense lesion in the pons in intravascular lymphoma 査読

    Iwamuro M, Kimura K, Kondo E, Otsuka F

    Intern Med   54 ( 18 )   2421 - 2   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.54.4614

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    その他リンク: http://orcid.org/0000-0003-0995-9405

  • Infective Internal Iliac Artery Aneurysm Caused by Campylobacter fetus 査読

    Hagiya H, Ogawa H, Takahashi Y, Hasegawa K, Hanayama Y, Otsuka F.

    Intern Med   54 ( 16 )   2021 - 4   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.54.4845

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  • A Nephrostomy-associated urinary tract Infection caused by elizabethkingia meningoseptica 査読

    Hagiya H, Ogawa H, Takahashi Y, Hasegawa K, Iwamuro M, Otsuka F.

    Intern Med   54 ( 24 )   3233 - 6   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.54.4998

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  • Klebsiella oxytoca producing IMP-1 detected as a first strain of carbapenem-resistant Enterobacteriacae in our hospital 査読

    Hagiya H, Ogawa H, Takahashi Y, Yamamoto A, Otsuka F.

    Intern Med   54 ( 22 )   2939 - 41   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.54.4965

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  • Clinical ineffectiveness of latamoxef for Stenotrophomonas maltophilia infection 査読 国際誌

    Hagiya H, Tasaka K, Sendo T, Otsuka F

    Infect Drug Resist   8   353 - 7   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2147/IDR.S90726

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  • Actinomyces turicensis bacteremia secondary to pyometra 査読

    Hagiya H, Ogawa H, Takahashi Y, Kimura K, Hasegawa K, Otsuka F.

    Intern Med   54 ( 21 )   2775 - 7   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.54.4637

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  • Neurosyphilis Is a Long-forgotten Disease but Still a Possible Etiology for Dementia 査読

    Hagiya H, Deguchi K, Kawada K, Otsuka F

    Intern Med   54 ( 21 )   2769 - 73   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.54.4956

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  • Cytomegalovirus as an Insidious Pathogen Causing Duodenitis 査読

    Hagiya H, Iwamuro M, Tanaka T, Hanayama Y, Otsuka F

    Acta Med Okayama   69 ( 5 )   319 - 23   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Relationships between causes of fever of unknown origin and inflammation markers: a multicenter collaborative retrospective study 査読

    Naito T, Torikai K, Mizooka M, Mitsumoto F, Kanazawa K, Ohno S, Morita H, Ukimura A, Mishima N, Otsuka F, Ohyama Y, Nara N, Murakami K, Mashiba K, Akazawa K, Yamamoto K, Tanei M, Yamanouchi M, Senda S, Tazuma S, Hayashi J

    Intern Med   54 ( 16 )   1989 - 94   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.54.3313

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  • Tetanus in a 19-year-old Japanese Woman 査読

    Hagiya H, Hirayama T, Ugawa T, Otsuka F

    Intern Med   54 ( 14 )   1825 - 1825   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.54.4404

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  • Relapsing Polychondritis Followed Up with FDG-PET 査読

    Hagiya H, Waseda K, Otsuka F.

    Intern Med   54 ( 13 )   1675 - 6   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.54.3752

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  • Eagle's Syndrome Manifesting as Chronic Swallowing Pain 査読

    Hagiya H, Waseda K, Ogawa H, Otsuka F

    Intern Med   54 ( 10 )   1321 - 1321   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.54.4262

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  • CT visualising infective vegetation. 国際誌

    Hideharu Hagiya, Kou Hasegawa, Kikuko Asano, Fumio Otsuka

    BMJ case reports   2014   2014年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/bcr-2014-207572

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  • 総合内科における化学療法への挑戦

    木村 耕介, 長谷川 功, 灘 隆宏, 萩谷 英大, 中村 絵里, 花山 宜久, 近藤 英生, 大塚 文男

    日本病院総合診療医学会雑誌   7 ( 2 )   90 - 90   2014年12月

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    記述言語:日本語   出版者・発行元:(一社)日本病院総合診療医学会  

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  • Fanconi症候群を呈した腎サルコイドーシスの1例

    大村 大輔, 長谷川 功, 萩谷 英大, 浅野 喜久子, 菊田 温恵, 花山 宜久, 近藤 英生, 片岡 仁美, 森永 裕士, 大塚 文男

    日本病院総合診療医学会雑誌   7 ( 2 )   72 - 73   2014年12月

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    記述言語:日本語   出版者・発行元:(一社)日本病院総合診療医学会  

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  • Gingival overgrowth caused by vitamin C deficiency associated with metabolic syndrome and severe periodontal infection: a case report. 査読 国際誌

    Kazuhiro Omori, Yoshihisa Hanayama, Koji Naruishi, Kentaro Akiyama, Hiroshi Maeda, Fumio Otsuka, Shogo Takashiba

    Clinical case reports   2 ( 6 )   286 - 95   2014年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    It has been suggested that vitamin C deficiency/scurvy is associated with gingival inflammatory changes; however, the disorder is very infrequently encountered in the modern era. Here, we report a case of extensive gingival overgrowth caused by vitamin C deficiency associated with metabolic syndrome and severe periodontal infection.

    DOI: 10.1002/ccr3.114

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  • Aortic vascular graft infection caused by Cardiobacterium valvarum: a case report. 査読 国際誌

    Hideharu Hagiya, Susumu Kokeguchi, Hiroko Ogawa, Tomohiro Terasaka, Kosuke Kimura, Koichi Waseda, Yoshihisa Hanayama, Kaori Oda, Hisatoshi Mori, Toru Miyoshi, Fumio Otsuka

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   20 ( 12 )   804 - 9   2014年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER JAPAN KK  

    A 53-year-old man with a past medical history of total arch replacement surgery and severe aortic regurgitation presented with a 1-month history of persistent general malaise, anorexia, body weight loss and night sweats. His recent history included gingival hyperplasia for 6 years, gingivitis after tooth extraction 3 years before, prolonged inflammatory status for 4 months, fundal hemorrhage and leg tenderness for 2 months. A pathogen was detected from blood culture, but conventional microbiological examination failed to identify the pathogen. The organism was eventually identified as Cardiobacterium valvarum by 16S rRNA analysis, and the patient was diagnosed with infective endocarditis and prosthetic vascular graft infection. The patient received intravenous antibiotic therapy using a combination of ceftriaxone and levofloxacin for 5 weeks and was discharged with a good clinical course.
    C. valvarum is a rare human pathogen in clinical settings. Only 10 cases have been reported to date worldwide, and therefore, the clinical characteristics of C. valvarum infection are not fully known. This is a first well-described case of C. valvarum infection in Japan, and further, a first report of aortic prosthetic vascular graft infection worldwide. Identification of C. valvarum is usually difficult due to its phenotypic characteristics, and molecular approaches would be required for both clinicians and microbiologists to facilitate more reliable diagnosis and uncover its clinical picture more clearly. (C) 2014, Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.jiac.2014.07.008

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  • 食欲低下・体重減少を主訴に来院した中枢性尿崩症の1例

    中村 絵里, 岡野 美咲, 灘 隆宏, 木村 耕介, 大村 大輔, 小川 弘子, 花山 宜久, 大塚 文男

    日本病院総合診療医学会雑誌   7 ( 2 )   74 - 74   2014年12月

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    記述言語:日本語   出版者・発行元:(一社)日本病院総合診療医学会  

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  • Pantoea dispersa bacteremia caused by central line-associated bloodstream infection

    Hideharu Hagiya, Fumio Otsuka

    BRAZILIAN JOURNAL OF INFECTIOUS DISEASES   18 ( 6 )   696 - 697   2014年11月

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    記述言語:英語   出版者・発行元:ELSEVIER BRAZIL  

    DOI: 10.1016/j.bjid.2014.06.006

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  • Mycotic abdominal aortic aneurysm caused by Campylobacter fetus: a case report and literature review. 国際誌

    Hideharu Hagiya, Mitsuaki Matsumoto, Hiroshi Furukawa, Tomoko Murase, Fumio Otsuka

    Annals of vascular surgery   28 ( 8 )   1933.e7-1933.e14   2014年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    Campylobacter spp. usually cause gastrointestinal infections, but among them, Campylobacter fetus is a well-known organism causing mycotic abdominal aortic aneurysm (MAAA), which requires proper surgical intervention and antibiotic therapy. We report a 65-year-old man who was successfully treated by an in situ operation using a rifampicin (RFP)-bonded J-Graft for C. fetus-induced MAAA. We performed a review of the English literature on MAAA caused by C. fetus and summarized the results of the cases (28 cases). All but 2 of the patients (92.9%) were men. Blood culture and arterial wall culture were positive in 63% and 73.1% of the cases, respectively. Aneurysm rupture was seen in half of the patients, and approximately half of those patients died. Among the 18 patients who underwent in situ graft replacement, only 1 patient (5.6%) died after surgery. Antibiotic therapy was performed for more than 1 month in most cases, and overall mortality rate was 25.9% (7 of 27 cases, 3 deaths before the operation and 4 deaths after surgery). Although extra-anatomic bypass has been conventionally performed after complete resection of an MAAA, the utility of in situ surgery has generally been recognized. Our review suggests that the in situ operation can be a choice also in cases of C. fetus-associated MAAA. Furthermore, our case suggested the clinical utility of a newly manufactured prosthetic graft, J-Graft, for such surgical treatment.

    DOI: 10.1016/j.avsg.2014.06.072

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  • Clinical Utility of String Test as A Screening Method for Hypermucoviscosity-phenotype Klebsiella pneumonia 査読 国際誌

    Hagiya H, Watanabe N, Maki M, Murase T, Otsuka F

    Acute Medicine & Surgery   1 ( 4 )   245 - 246   2014年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/ams2.40

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  • Emergence of third-generation cephalosporin-resistant Enterobacteriacae at a Japanese critical care setting 査読 国際誌

    Hagiya H, Murase T, Suzuki M, Otsuka F, Shibayama K

    Acute Medicine & Surgery   1 ( 4 )   256 - 258   2014年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/ams2.64

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  • Melatonin counteracts BMP-6 regulation of steroidogenesis by rat granulosa cells. 査読 国際誌

    Nakamura E, Otsuka F, Terasaka T, Inagaki K, Hosoya T, Tsukamoto-Yamauchi N, Toma K, Makino H

    J Steroid Biochem Mol Biol   143   233 - 9   2014年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jsbmb.2014.04.003

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  • 多様化する岡山大学病院卒後臨床研修センター事務スタッフの役割

    渡辺 文恵, 小比賀 美香子, 三好 智子, 野間 和広, 片岡 仁美, 大塚 文男

    医学教育   45 ( Suppl. )   169 - 169   2014年7月

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    記述言語:日本語   出版者・発行元:(一社)日本医学教育学会  

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  • Vasohibin-1 deficiency enhances renal fibrosis and inflammation after unilateral ureteral obstruction 査読 国際誌

    Watatani H, Maeshima Y, Hinamoto N, Yamasaki H, Ujike H, Tanabe K, Sugiyama H, Otsuka F, Sato Y, Makino H

    Physiol Rep   2 ( 6 )   2014年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.14814/phy2.12054

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  • Retroperitoneal bronchogenic cyst: a rare incidentaloma discovered in a juvenile hypertensive patient. 査読 国際誌

    Tomohiro Terasaka, Fumio Otsuka, Kanako Ogura-Ochi, Tomoko Miyoshi, Kenichi Inagaki, Yasuyuki Kobayashi, Yasutomo Nasu, Hirofumi Makino

    Hypertension research : official journal of the Japanese Society of Hypertension   37 ( 6 )   595 - 7   2014年6月

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    記述言語:英語   出版者・発行元:NATURE PUBLISHING GROUP  

    DOI: 10.1038/hr.2014.38

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  • Runx3 Regulates Ovulation and Steroidogenesis in Granulosa Cells in Mice

    Fumiya Ojima, Yuka Saito, Yukiko Tsuchiya, Kenichi Inagaki, Eri Nakamura, Fumio Otsuka, Maho Ogoshi, Sakae Takeuchi, Sumio Takahashi

    ENDOCRINE REVIEWS   35 ( 3 )   2014年6月

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    記述言語:英語   出版者・発行元:ENDOCRINE SOC  

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  • PRL分泌に対するBMP-4とメラトニン作用の影響 GH3細胞を用いた検討

    越智 可奈子, 大塚 文男, 当真 貴志雄, 中村 絵里, 塚本 尚子, 稲垣 兼一, 三村 由香里, 小倉 俊郎, 岩崎 泰正, 槇野 博史

    日本内分泌学会雑誌   90 ( 1 )   305 - 305   2014年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 【市中感染型MRSAの動向と対処法】ST8/non-USA300株による全身播種性市中感染型MRSA感染症の1例

    萩谷 英大, 久恒 順三, 森本 直樹, 大塚 文男, 菅井 基行

    化学療法の領域   30 ( 5 )   779 - 787   2014年4月

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    記述言語:日本語   出版者・発行元:(株)医薬ジャーナル社  

    市中感染型メチシリン耐性黄色ブドウ球菌(CA-MRSA)は重症感染症を引き起こす起炎菌として知られているが、遺伝子的に多様であり、さまざまなタイプが世界中に分布している。本症例は、multilocus sequence type 8、IV型SCCmec(staphylococcal cassette chromosome mec)、III型コアグラーゼ陽性、Panton-Valentine leukocidinおよびarginine catabolic mobile element陰性の単一株により発症した全身播種性の重症CA-MRSA感染症のまれな一例である。筋骨格系を中心に全身に感染巣を形成しており、遺伝学的に同一のCA-MRSAを患者の異なる11部位より検出した。わが国におけるCA-MRSAの疫学および病原性は未解明である部分が多いが、本症例でもCA-MRSAの高病原性が示唆された。今後さらなる解析が期待される。(著者抄録)

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  • Chromobacterium violaceum nosocomial pneumonia in two Japanese patients at an intensive care unit. 国際誌

    Hideharu Hagiya, Tomoko Murase, Masato Suzuki, Keigo Shibayama, Yumi Kokumai, Naoto Watanabe, Miyako Maki, Fumio Otsuka

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   20 ( 2 )   139 - 42   2014年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER JAPAN KK  

    Chromobacterium violaceum is sensitive to temperature and the infection is usually confined to tropical or subtropical regions. Since Japan has a warm climate, C. violaceum has been scarcely isolated from clinical specimens. With global warming, however, the geographical distribution of C. violaceum infection is likely to change. We report two cases of C. violaceum nosocomial pneumonia that occurred at an intensive care center in Japan. C. violaceum was first detected from a patient in the same center as a pathogenic organism of pneumonia. Later, the organism was isolated from sputum and a ventilator circuit tube of another patient in the center. The two patients were admitted to the center in nearby beds for several days. All of the pathogens were confirmed to be C. violaceum by the nucleic acid sequence of the 16S rRNA gene and were proven to be genetically identical organisms by pulsed field gel electrophoresis. Both patients were managed with well-humidified and heated oxygen using a venturi mask and ventilator to promote excretion of sputum. It was thought that the medical respiratory care devices that provide a humid and warm environment, an optimal condition for proliferation of C. violaceum, can contribute to C. violaceum infection in a hospital environment.

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  • Long-term observation of osteomalacia caused by adefovir-induced Fanconi's syndrome. 査読

    Tomohiro Terasaka, Eijiro Ueta, Hirotaka Ebara, Koichi Waseda, Yoshihisa Hanayama, Akinobu Takaki, Tomoko Kawabata, Hitoshi Sugiyama, Ko Hidani, Fumio Otsuka

    Acta medica Okayama   68 ( 1 )   53 - 6   2014年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    A 64-year-old man suffering polyarthralgia and bone pain was referred to our hospital. Renal dysfunction, hypophosphatemia and increased levels of bone alkaline phosphatase were found. The patient's serum creatinine level had gradually increased after the initiation of adefovir dipivoxil administration for hepatitis B. In agreement with multifocal uptakes of bone scintigraphy, iliac bone biopsy revealed an abnormal increase in osteoid tissues. Reducing the dose of adefovir and initiating the administration of eldecalcitol were effective for reducing proteinuria and glucosuria, and for ameliorating bone pain with an increase in serum phosphate level. This case first showed a clinical course of hypophosphatemic osteomalacia caused by secondary Fanconi's syndrome for 8 years after adefovir administration. Early diagnosis is important for the reversibility of bone damage and for a better renal prognosis.

    DOI: 10.18926/AMO/52145

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  • Postpartum Breast Abscess Caused by Community-Acquired Methicillin-Resistant Staphylococcus aureus in Japan

    Hideharu Hagiya, Sumiko Shiota, Wakana Sugiyama, Fumio Otsuka

    BREASTFEEDING MEDICINE   9 ( 1 )   45 - 46   2014年1月

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    記述言語:英語   出版者・発行元:MARY ANN LIEBERT, INC  

    DOI: 10.1089/bfm.2013.0057

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  • Acute generalized exanthematous pustulosis caused by daptomycin in a critically ill burn victim.

    Hideharu Hagiya, Maya Kimura, Toru Miyamoto, Yuto Haruki, Fumio Otsuka

    Internal medicine (Tokyo, Japan)   53 ( 5 )   511 - 4   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    Acute generalized exanthematous pustulosis (AGEP) is a self-limiting type of drug eruption that frequently occurs as a reaction to antibiotics, particularly penicillins or macrolides. Daptomycin (DAP) is a newly developed antibiotic that specifically targets methicillin-resistant Staphylococcus aureus infection. We herein present the case of a 77-year-old severe burn victim who was diagnosed with DAP-induced AGEP while receiving treatment in an intensive care unit. Although rare, physicians should be aware that the administration of DAP can cause AGEP, which may complicate the clinical course of patients with a high fever and inflammation.

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  • Fosfomycin for the treatment of prostate infection. 査読

    Hideharu Hagiya, Megumi Ninagawa, Kou Hasegawa, Tomohiro Terasaka, Kosuke Kimura, Koichi Waseda, Yoshihisa Hanayama, Toshiaki Sendo, Fumio Otsuka

    Internal medicine (Tokyo, Japan)   53 ( 22 )   2643 - 6   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    A 69-year-old man with diabetes mellitus was diagnosed with a prostate abscess. Although the pathogen was fluoroquinolone-resistant Escherichia coli and the oral administration of trimethoprim-sulfamethoxazole was initiated, the infection recurred after three months. The antibiotic therapy was subsequently changed to intravenous fosfomycin, and the patient's condition promptly improved. Four weeks of fosfomycin therapy was successfully continued without any adverse events. In the era of antibiotic resistance, revival of forgotten drugs is an important issue for clinicians. Fosfomycin can be applied as an alternative option for prostate infections, considering the remaining susceptibility of multidrug-resistant pathogens to fosfomycin and the good pharmacokinetics of this drug in prostatic tissue.

    DOI: 10.2169/internalmedicine.53.3098

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  • Filarial chyluria as a rare cause of urinary retention. 査読

    Hideharu Hagiya, Tomohiro Terasaka, Kosuke Kimura, Asuka Satou, Kikuko Asano, Koichi Waseda, Yoshihisa Hanayama, Takahide Takahashi, Michinori Aoe, Koji Iio, Toshiyuki Watanabe, Eisei Kondo, Fumio Otsuka

    Internal medicine (Tokyo, Japan)   53 ( 17 )   2001 - 5   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    We herein describe a case of Wuchereria bancrofti infection in a previously healthy 37-year-old Nepalese man. The patient presented with a history of milky urine with subsequent acute urinary retention lasting for a few days. The presence of microfilariae was confirmed on both peripheral blood and urine smears obtained at midnight. He was conservatively treated with diethylcarbamazine combined with doxycycline. Filariasis was previously endemic in southern parts of Japan, although it has been eradicated. Clinicians should remember filariasis as a potential etiology of urinary retention, especially in cases that may be associated with imported infectious disease.

    DOI: 10.2169/internalmedicine.53.2572

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  • Recurrent Stenotrophomonas maltophilia bacteremia after iliac crest bone graft harvest. 査読

    Hideharu Hagiya, Hiroko Ogawa, Tomoharu Ishida, Tomohiro Terasaka, Kosuke Kimura, Koichi Waseda, Yoshihisa Hanayama, Masahiro Horita, Yasunori Shimamura, Eisei Kondo, Fumio Otsuka

    Internal medicine (Tokyo, Japan)   53 ( 15 )   1693 - 8   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    We describe a rare case of recurrent Stenotrophomonas maltophilia bacteremia in a previously healthy 45-year-old man. The infection was caused by osteomyelitis at the site of an iliac crest bone graft harvest. A genetic analysis using enterobacterial repetitive intergenic consensus polymerase chain reaction (ERIC-PCR) revealed that the blood isolates and pathogens obtained from the surgical wound were identical. Initial treatment with levofloxacin and cefozopran was ineffective, but the patient's infection was successfully treated by long-term administration of latamoxef and trimethoprim-sulfamethoxazole. The present case suggests that attention should be given to the possibility of S. maltophilia infection in any situations.

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  • Successful treatment of persistent MRSA bacteremia using high-dose daptomycin combined with rifampicin. 査読

    Hideharu Hagiya, Tomohiro Terasaka, Kosuke Kimura, Asuka Satou, Kikuko Asano, Koichi Waseda, Yoshihisa Hanayama, Fumio Otsuka

    Internal medicine (Tokyo, Japan)   53 ( 18 )   2159 - 63   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    We herein report a case of persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia that was successfully treated with combination therapy consisting of high-dose daptomycin (DAP, 10 mg/kg) and rifampicin. The patient's condition was complicated with multiple infectious foci, including an iliopsoas abscess and epidural abscess, as well as discitis and spondylitis at the cervical, thoracic and lumbar levels. Monotherapy treatments with vancomycin, linezolid and usual-dose DAP were all ineffective. It has been shown that usual-dose DAP administration may result in the emergence of a resistant strain and treatment failure. We would like to emphasize the importance of high-dose DAP therapy for MRSA bacteremia, a condition with a potentially high mortality rate.

    DOI: 10.2169/internalmedicine.53.2711

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  • Actinomyces meyeri meningitis: the need for anaerobic cerebrospinal fluid cultures. 査読

    Hideharu Hagiya, Fumio Otsuka

    Internal medicine (Tokyo, Japan)   53 ( 1 )   67 - 71   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    We herein present a rare case of Actinomyces meyeri-induced meningitis that occurred in a patient of advanced age with poor oral hygiene. Although Gram staining of the cerebrospinal fluid (CSF) revealed Grampositive rods and a blood culture was positive for the organism, a bacterial culture of the CSF was negative. Anaerobic cultures of CSF specimens are not routinely performed; however, anaerobes are sometimes involved in central nervous system infection. We therefore believe that anaerobic cultures should be considered in high-risk cases, such as those involving necrotizing bowel lesions or poor oral hygiene. A negative result on a CSF culture can result in misdiagnosis and inappropriate treatment.

    DOI: 10.2169/internalmedicine.53.0403

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  • Ceftriaxone-induced biliary sludge in a patient with uncontrolled diabetes.

    Hideharu Hagiya, Kou Hasegawa, Kikuko Asano, Fumio Otsuka

    Internal medicine (Tokyo, Japan)   53 ( 21 )   2549 - 50   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    DOI: 10.2169/internalmedicine.53.3377

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  • Calcium oxalate crystals in the lungs.

    Hideharu Hagiya, Soichiro Fushimi, Junya Itakura, Fumio Otsuka

    Internal medicine (Tokyo, Japan)   53 ( 17 )   2025 - 6   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    DOI: 10.2169/internalmedicine.53.2772

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  • Epiglottic aphthous ulcers.

    Hideharu Hagiya, Hiroyuki Hanakawa, Takayuki Katsuyama, Fumio Otsuka

    Internal medicine (Tokyo, Japan)   53 ( 15 )   1731 - 1731   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    DOI: 10.2169/internalmedicine.53.2734

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  • A case of vascular graft infection caused by Staphylococcus lugdunensis after femoropopliteal bypass operation.

    Hideharu Hagiya, Mitsuaki Matsumoto, Takahiko Yamasawa, Yuto Haruki, Fumio Otsuka

    Acta medica Okayama   68 ( 3 )   171 - 5   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    A 79-year-old man who had undergone a right femoropopliteal (FP) bypass operation 6 weeks previously was diagnosed with vascular graft infection caused by Staphylococcus lugdunensis. Another FP bypass operation was performed, with long-term administration of antibiotics, and the patient eventually recovered well without any recurrences for over 2 years. Although S. lugdunens is classified as coagulase-negative Staphylococcus, its pathogenicity has been reported to be equal to that of S. aureus. Based on the literature review, the organism characteristically colonizes the inguinal area of human skin;thus, operations such as FP bypass grafting may place patients at a relatively high risk for infection by S. lugdunensis, a potentially high-pathogenicity organism.

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  • Triangle sign on neck MRI.

    Kosuke Kimura, Hideharu Hagiya, Yoshihisa Hanayama, Fumio Otsuka

    Internal medicine (Tokyo, Japan)   53 ( 9 )   1035 - 6   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    DOI: 10.2169/internalmedicine.53.1777

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  • Effects of antibiotics administration on the incidence of wound infection in percutaneous dilatational tracheostomy 査読

    Hagiya H, Naito H, Hagioka S, Okahara S, Morimoto N, Kusano N, Otsuka F

    Acta Med Okayama   68 ( 2 )   57 - 62   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Comprehensive analysis of systemically disseminated ST8/non-USA300 type community-acquired methicillin-resistant Staphylococcus aureus infection.

    Hideharu Hagiya, Junzo Hisatsune, Taro Kojima, Sumiko Shiota, Hiromichi Naito, Shingo Hagioka, Naoki Morimoto, Fumio Otsuka, Motoyuki Sugai

    Internal medicine (Tokyo, Japan)   53 ( 8 )   907 - 12   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is genetically heterogeneous and various genotypes are spreading worldwide. We herein report a case of systematically disseminated Japan-intrinsic CA-MRSA infection that was successfully treated. A genetically identical single strain was isolated from a total of 11 different parts of the patient's body, and the pathogen was found to be multilocus sequence type 8, staphylococcal cassette chromosome mec IV, coagulase type III and negative for both Panton-Valentine leukocidin and arginine catabolic mobile element. The epidemiology and pathogenicity of the Japan-intrinsic CA-MRSA strain remain unknown, and further investigation of this life-threatening organism is warranted.

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  • Rhombencephalitis caused by Listeria monocytogenes.

    Hideharu Hagiya, Fumio Otsuka

    Internal medicine (Tokyo, Japan)   53 ( 6 )   639 - 40   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

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  • Diagnostic workup for fever of unknown origin: a multicenter collaborative retrospective study 査読 国際誌

    Naito T, Mizooka M, Mitsumoto F, Kanazawa K, Torikai K, Ohno S, Morita H, Ukimura A, Mishima N, Otsuka F, Ohyama Y, Nara N, Murakami K, Mashiba K, Akazawa K, Yamamoto K, Senda S, Yamanouchi M, Tazuma S, Hayashi J

    BMJ Open   3 ( 12 )   e003971 - e003971   2013年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1136/bmjopen-2013-003971

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  • Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation by GT1-7 cells. 査読 国際誌

    Terasaka T, Otsuka F, Tsukamoto N, Nakamura E, Inagaki K, Toma K, Ogura-Ochi K, Glidewell-Kenney C, Lawson MA, Makino H

    Mol Cell Endocrinol   381 ( 1-2 )   8 - 15   2013年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.mce.2013.07.009

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  • FDG-PETで集積を認めたACTH産生性下垂体腺腫の1例

    越智 可奈子, 大塚 文男, 細谷 武史, 原 孝行, 当真 貴志雄, 中村 絵里, 塚本 尚子, 稲垣 兼一, 三好 智子, 三村 由香里, 小倉 俊郎, 山田 正三, 槇野 博史

    日本内分泌学会雑誌   89 ( 3 )   935 - 935   2013年12月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 不明熱診断における検査の有効性とその進め方

    立古 浩雅, 草野 展周, 片岡 仁美, 三好 智子, 花山 宜久, 金森 達也, 江原 弘貴, 小川 弘子, 小比賀 美香子, 大塚 文男

    日本病院総合診療医学会雑誌   5 ( 2 )   78 - 78   2013年12月

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    記述言語:日本語   出版者・発行元:(一社)日本病院総合診療医学会  

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  • 2型糖尿病初期治療における経口糖尿病降下薬の処方選択基準に関するアルゴリズムの作成と有用性の検討 査読

    塩見明日香、三好智子、村上和敏、水島孝明、黒田真生、尾上 洋、相良英憲、座間味義人、大塚文男、名倉弘哲

    ライフ・サイエンスProgress in Medicine   33 ( 10 )   2261 - 2268   2013年10月

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    記述言語:日本語  

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  • 先天性副腎皮質過形成に両側巨大副腎骨髄脂肪腫を合併した一例

    原 孝行, 稲垣 兼一, 細谷 武史, 当真 貴志雄, 越智 可奈子, 中村 絵里, 塚本 尚子, 三好 智子, 大塚 文男, 槇野 博史

    日本内分泌学会雑誌   89 ( 2 )   625 - 625   2013年9月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • Melatonin receptor activation suppresses adrenocorticotropin production via BMP-4 action by pituitary AtT20 cells. 査読 国際誌

    Tsukamoto N, Otsuka F, Ogura-Ochi K, Inagaki K, Nakamura E, Toma K, Terasaka T, Iwasaki Y, Makino H

    Mol Cell Endocrinol   375 ( 1-2 )   1 - 9   2013年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.mce.2013.05.010

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  • Systemic varicella-zoster virus infection in two critically ill patients in an intensive care unit 査読 国際誌

    Hagiya H, Kimura M, Miyamoto T, Otsuka F

    Virol J   10   225 - 225   2013年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/1743-422X-10-225

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  • High-Fidelity Simulatorを使用したトレーニングの自己評価方法の比較

    万代 康弘, 三好 智子, 小川 弘子, 上田 順子, 香西 佳美, 大塚 文男, 片岡 仁美, 谷本 光音

    医学教育   44 ( Suppl. )   82 - 82   2013年7月

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    記述言語:日本語   出版者・発行元:(一社)日本医学教育学会  

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  • 岡山大学病院卒後臨床研修センターにおける専属事務スタッフの取り組み

    渡辺 文恵, 小比賀 美香子, 野間 和広, 三好 智子, 片岡 仁美, 尾崎 敏文, 大塚 文男

    医学教育   44 ( Suppl. )   197 - 197   2013年7月

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    記述言語:日本語   出版者・発行元:(一社)日本医学教育学会  

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  • 岡山大学病院卒後臨床研修プログラムにおける地域医療研修の取り組み(第二報)

    片岡 仁美, 小比賀 美香子, 三好 智子, 渡辺 文恵, 野間 和弘, 金森 達也, 佐藤 勝, 大塚 文男, 尾崎 敏文, 岩瀬 敏秀

    医学教育   44 ( Suppl. )   120 - 120   2013年7月

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    記述言語:日本語   出版者・発行元:(一社)日本医学教育学会  

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  • 岡山大学病院初期臨床研修における「たすきがけプログラム」 アンケート結果より

    小比賀 美香子, 片岡 仁美, 渡辺 文恵, 野間 和広, 三好 智子, 尾崎 敏文, 大塚 文男

    医学教育   44 ( Suppl. )   196 - 196   2013年7月

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    記述言語:日本語   出版者・発行元:(一社)日本医学教育学会  

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  • Erdheim-Chester病が強く疑われた下垂体機能低下症の一例 査読

    三好智子、大塚文男、稲垣兼一、田中康司、越智可奈子、藤井一恭、藤井伸治、当真貴志雄、中村絵里、塚本尚子、武田昌也、三村由香里、小倉俊郎、景山甚郷、槇野博史

    日本内分泌学会雑誌   89 ( suppl )   21 - 23   2013年6月

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    記述言語:日本語  

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  • 長期の精神科入院から紹介発見されたACTH単独欠損症の一例

    杉山 晃一, 江原 弘貴, 筑木 隆雄, 早稲田 公一, 花山 宜久, 三好 智子, 水島 孝明, 片岡 仁美, 草野 展周, 当真 貴志雄, 吉永 圭一郎, 大塚 文男

    日本病院総合診療医学会雑誌   4 ( 2 )   87 - 87   2013年6月

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    記述言語:日本語   出版者・発行元:(一社)日本病院総合診療医学会  

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  • GRK-6 mediates FSH action synergistically enhanced by estrogen and the oocyte in rat granulosa cells. 査読 国際誌

    Miyoshi T, Otsuka F, Shimasaki S

    Biochemical and Biophysical Research Communications   434 ( 2 )   401 - 6   2013年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bbrc.2013.04.002

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  • Estrogen facilitates osteoblast differentiation by upregulating bone morphogenetic protein-4 signaling. 査読 国際誌

    Matsumoto Y, Otsuka F, Takano-Narazaki M, Katsuyama T, Nakamura E, Tsukamoto N, Inagaki K, Sada KE, Makino H

    Steroids   78 ( 5 )   513 - 20   2013年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.steroids.2013.02.011

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  • 中枢性尿崩症で発症したリンパ球性汎下垂体炎の1例 査読

    竹本玲加、大塚文男、森下美智子、森本尚孝、寺田洋明、斉藤信幸、正岡哲也、宮谷克也、田中健大

    三豊総合病院雑誌   34   59 - 63   2013年4月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • メラトニン受容体刺激によるACTH分泌抑制とその機序の検討

    塚本 尚子, 大塚 文男, 越智 可奈子, 中村 絵里, 当真 貴志雄, 三好 智子, 稲垣 兼一, 岩崎 泰正, 槇野 博史

    日本内分泌学会雑誌   89 ( 1 )   218 - 218   2013年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • Gonadotrope細胞におけるSomatostatin受容体反応性の検討

    当真 貴志雄, 大塚 文男, 塚本 尚子, 大國 皓平, 中村 絵里, 越智 可奈子, 武田 昌也, 三好 智子, 稲垣 兼一, 槇野 博史

    日本内分泌学会雑誌   89 ( 1 )   296 - 296   2013年4月

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  • 皮膚筋炎の診断時に褐色細胞腫の合併を認めた一例

    三好 智子, 大塚 文男, 稲垣 兼一, 当真 貴志雄, 勝山 隆行, 塚本 尚子, 中村 絵里, 越智 可奈子, 橋本 洋夫, 槇野 博史

    日本内分泌学会雑誌   89 ( 1 )   340 - 340   2013年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 卵胞ステロイド産生におけるソマトスタチン反応性の検討

    中村 絵里, 大塚 文男, 塚本 尚子, 当真 貴志雄, 越智 可奈子, 三好 智子, 稲垣 兼一, 武田 昌也, 槇野 博史

    日本内分泌学会雑誌   89 ( 1 )   248 - 248   2013年4月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 骨芽細胞分化に対するBMPとERの相互作用の検討

    大塚 文男, 楢崎 真理子, 勝山 隆行, 松本 佳則, 越智 可奈子, 当真 貴志雄, 中村 絵里, 塚本 尚子, 三好 智子, 稲垣 兼一, 小倉 俊郎, 槇野 博史

    日本内分泌学会雑誌   89 ( 1 )   276 - 276   2013年4月

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  • 左眼瞼下垂を契機に診断された若年胃癌のトルコ鞍部転移の一例 査読

    稲垣兼一、当真貴志雄、中村絵里、越智可奈子、塚本尚子、三好智子、三村由香里、小倉俊郎、大塚文男、槇野博史

    ACTH Related Peptides   24   56 - 58   2013年3月

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  • Involvement of bone morphogenetic protein activity in somatostatin actions on ovarian steroidogenesis. 査読 国際誌

    Nakamura E, Otsuka F, Inagaki K, Tsukamoto N, Ogura-Ochi K, Miyoshi T, Toma K, Takeda M, Makino H

    J Steroid Biochem Mol Biol   134   67 - 74   2013年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jsbmb.2012.10.018

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  • Is wet swab superior to dry swab as an intranasal screening test? 査読 国際誌

    Hagiya H, Mio M, Murase T, Egawa K, Kokumai Y, Uchida T, Morimoto N, Otsuka F, Shiota S

    J Intensive Care   1 ( 1 )   10 - 10   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1186/2052-0492-1-10

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  • Group a streptococcal meningitis in a patient with palmoplantar pustulosis 査読

    Hagiya H, Otsuka F

    Intern Med   52 ( 23 )   2675 - 8   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.52.0499

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  • Disseminated Gonococcal Infection in An Elderly Japanese Man 査読

    Hagiya H, Onishi N, Ebara H, Hanayama Y, Kokeguchi S, Nose M, Kusano N, Otsuka F

    Intern Med   52 ( 23 )   2669 - 73   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.52.1033

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  • Ineffectiveness of Daptomycin in the treatment of Septic Pulmonary Emboli and Persistent Bacteremia Caused by Methicillin-Resistant Staphylococcus aureus 査読

    Hagiya H, Hagioka S, Otsuka F

    Intern Med   52 ( 22 )   2577 - 82   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.2169/internalmedicine.52.0023

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  • A Comprehensive Anaiysis of 1 74 Febri:e Patients Admitted to Okayama University Hospital 査読

    Ryuko H, Otsuka F

    Acta Med Okayama   67 ( 4 )   227 - 37   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

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  • Multifunctional bone morphogenetic protein system in endocrinology.

    Fumio Otsuka

    Acta medica Okayama   67 ( 2 )   75 - 86   2013年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    New biological activities of bone morphogenetic proteins (BMPs) in the endocrine system have recently been revealed. The BMP system is composed of approximately 30 ligands and preferential combinations of type I and type II receptors. The BMP system not only induces bone formation but also plays unique tissue-specific roles in various organs. For instance, the ovarian BMP system is a physiological inhibitor of luteinization in growing ovarian follicles. In the ovary, the expression of oocyte-derived BMP-15 is critical for female reproduction. In the pituitary, BMP-4 is a key player for initial development of the anterior pituitary, while it is also functionally involved in some differentiated pituitary tumors, including prolactinoma and Cushing's disease. In the adrenal glands, BMP-6 and BMP-4 modulate aldosterone and catecholamine production, respectively, which contributes to a functional interaction between the cortex and medulla. In the present review, recent advances in BMP biology in the field of endocrinology are described and the possibility for clinical application of BMP activity is discussed.

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  • An in vivo role of bone morphogenetic protein-6 in aldosterone production by rat adrenal gland. 査読 国際誌

    Matsumoto Y, Otsuka F, Inagaki K, Tsukamoto N, Takano-Narazaki M, Miyoshi T, Nakamura E, Ogura-Ochi K, Takeda M, Makino H

    J Steroid Biochem Mol Biol   132 ( 1-2 )   8 - 14   2012年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.jsbmb.2012.04.004

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  • Evaluation of weekly-reduction regimen of glucocorticoids in combination with cyclophosphamide for anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis in Japanese patients. 査読 国際誌

    Yoshinori Matsumoto, Ken-Ei Sada, Fumio Otsuka, Mariko Takano, Noriko Toyota, Koichi Sugiyama, Hiroshi Wakabayashi, Tomoko Kawabata, Hirofumi Makino

    Rheumatology international   32 ( 10 )   2999 - 3005   2012年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER HEIDELBERG  

    The current therapeutic regimen recommended by the European League against Rheumatism (EULAR) for anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is continuation of initially administered doses of glucocorticoids (GCs) in combination with cyclophosphamide (CYC) for 1 month followed by gradual tapering. Considering the adverse effects of GCs, another tapering regimen of GCs with CYC, which was characterized by tapering GCs weekly, was reported by the British Society of Rheumatology (weekly-reduction regimen). The aim of the present study is to evaluate the safety and efficacy of this weekly-reduction regimen for Japanese AAV patients in comparison with the monthly-reduction regimen recommended by the EULAR. We retrospectively reviewed medical records of adult patients newly diagnosed with AAV during the period from April 2000 to December 2010. The outcome measures were rates of remission, relapse, infection, and GC-induced diabetes mellitus during the first 12 months. Clinical data in the two groups and categorial variables with a possible relation to the outcomes were compared by using the t test and chi-square test, respectively. Twenty-four patients were enrolled in our study. All of the patients achieved remission, and the rates of relapse during the first 12 months were not statistically different between the two groups (P = 0.16). Patients treated with the weekly-reduction regimen were less liable to have infection (P = 0.03) and impaired glucose tolerance (P = 0.017), compared with those treated with the monthly-reduction regimen. A therapeutic strategy using the weekly-reduction regimen of GCs would be effective and would have fewer side effects than the monthly-reduction regimen.

    DOI: 10.1007/s00296-011-2136-z

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  • Pro-apoptotic effects of imatinib on PDGF-stimulated pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension. 国際誌

    Kazufumi Nakamura, Satoshi Akagi, Aiko Ogawa, Kengo F Kusano, Hiromi Matsubara, Daiji Miura, Soichiro Fuke, Nobuhiro Nishii, Satoshi Nagase, Kunihisa Kohno, Hiroshi Morita, Takahiro Oto, Ryutaro Yamanaka, Fumio Otsuka, Aya Miura, Chikao Yutani, Tohru Ohe, Hiroshi Ito

    International journal of cardiology   159 ( 2 )   100 - 6   2012年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    BACKGROUND: Remodeling of the pulmonary artery by an inappropriate increase of pulmonary artery smooth muscle cells (PASMCs) is problematic in the treatment of idiopathic pulmonary arterial hypertension (IPAH). Effective treatment that achieves reverse remodeling is required. The aim of this study was to assess the pro-apoptotic effects of imatinib, a platelet-derived growth factor (PDGF)-receptor tyrosine kinase inhibitor, on PASMCs obtained from patients with IPAH. METHODS: PASMCs were obtained from 8 patients with IPAH undergoing lung transplantation. Cellular proliferation was assessed by (3)H-thymidine incorporation. Pro-apoptotic effects of imatinib were examined using TUNEL and caspase-3,7 assays and using transmission electron microscopy. RESULTS: Treatment with imatinib (0.1 to 10 μg/mL) significantly inhibited PDGF-BB (10 ng/mL)-induced proliferation of PASMCs from IPAH patients. Imatinib (1 μg/mL) did not induce apoptosis in quiescent IPAH-PASMCs, but it had a pro-apoptotic effect on IPAH-PASMCs stimulated with PDGF-BB. Imatinib did not induce apoptosis in normal control PASMCs with or without PDGF-BB stimulation. PDGF-BB induced phosphorylation of Akt at 15 min, and Akt phosphorylation was inhibited by imatinib in IPAH-PASMCs. Akt-I-1/2 (1 μmol/L), an Akt inhibitor, in the presence of PDGF-BB significantly increased apoptotic cells compared with the control condition. Thus, Akt-I-1/2 could mimic the effects of imatinib on PASMCs. CONCLUSION: Imatinib has anti-proliferative and pro-apoptotic effects on IPAH-PASMCs stimulated with PDGF. The inhibitory effect of imatinib on Akt phosphorylation induced by PDGF plays an important role in the pro-apoptotic effect.

    DOI: 10.1016/j.ijcard.2011.02.024

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  • Regulatory role of kit ligand-c-kit interaction and oocyte factors in steroidogenesis by rat granulose cells. 査読 国際誌

    Miyoshi T, Otsuka F, Nakamura E, Inagaki K, Ogura-Ochi K, Tsukamoto N, Takeda M, Makino H

    Mol Cell Endocrinol   358 ( 1 )   18 - 26   2012年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.mce.2012.02.011

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  • Bone morphogenetic protein-3b(BMP-3)inhibits osteoblast differentiation via Smad2/3 pathway by counteracting Smad1/5/8 signaling. 査読 国際誌

    Matsumoto Y, Otsuka F, Hino J, Miyoshi T, Takano M, Miyazato M, Makino H, Kanagawa K

    Mol Cell Endocrinol   350 ( 1 )   78 - 86   2012年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.mce.2011.11.023

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  • Enhanced expression of bone morphogenetic protein system in aldosterone-treated mouse kidneys. 査読 国際誌

    Suzuki J, Otsuka F, Matsumoto Y, Inagaki K, Miyoshi T, Takeda M, Tsukamoto N, Nakamura E, Ogura T, Makino H

    Hypertens Res   35 ( 3 )   312 - 7   2012年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/hr.2011.186

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  • BMP action in the pituitary: its possible role in modulating somatostatin sensitivity in pituitary tumor cells. 査読 国際誌

    Fumio Otsuka, Naoko Tsukamoto, Tomoko Miyoshi, Yasumasa Iwasaki, Hirofumi Makino

    Molecular and cellular endocrinology   349 ( 2 )   105 - 10   2012年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER IRELAND LTD  

    The existence of a functional bone morphogenetic protein (BMP) system in the pituitary has been recognized. Recent studies have provided evidence that BMPs elicit differential actions in the regulation of prolactin (PRL) and adrenocorticotropin (ACTH) release in lactotropinoma and corticotropinoma cells, respectively. BMPs play a key role in the modulation of somatostatin receptor (SSTR) sensitivity of lactosomatotrope cells in an autocrine/paracrine manner. In addition, SSTR action enhances BMP responsiveness in corticotrope cells. The functional link between BMP receptor signaling and SSTR actions may be crucial for individual tolerance to somatostatin analogs for controlling PRL and ACTH production. Adjustment of the endogenous SSTR sensitivity may be an effective strategy to inhibit the growth activity and hormonal productivity of intractable pituitary tumors.

    DOI: 10.1016/j.mce.2011.10.017

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  • Interaction between gonadotropin-releasing hormone and bone morphogenetic protein-6 and -7 signaling in LβT2 gonadotrope cells. 査読 国際誌

    Takeda M, Otsuka F, Takahashi H, Inagaki K, Miyoshi T, Tsukamoto N, Makino H, Lawson MA

    Mol Cell Endocrinol   348 ( 1 )   147 - 54   2012年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.mce.2011.08.001

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  • Peroxisome proliferator-activated receptor activity is involved in the osteoblastic differentiation regulated by bone morphogenetic proteins and tumor necrosis factor-α. 査読 国際誌

    Takano M, Otsuka F, Matsumoto Y, Inagaki K, Takeda M, Nakamura E, Tsukamoto N, Miyoshi T, Sada KE, Makino H

    Molecular and cellular endocrinology   348 ( 1 )   224 - 32   2012年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.mce.2011.08.027

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  • Mutual regulation of growth hormone and bone morphogenetic protein system in steroidogenesis by rat granulosa cells. 査読 国際誌

    Eri Nakamura, Fumio Otsuka, Kenichi Inagaki, Tomoko Miyoshi, Yoshinori Matsumoto, Kanako Ogura, Naoko Tsukamoto, Masaya Takeda, Hirofumi Makino

    Endocrinology   153 ( 1 )   469 - 80   2012年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ENDOCRINE SOC  

    GH induces preantral follicle growth and differentiation with oocyte maturation. However, the effects of GH on ovarian steroidogenesis and the mechanisms underlying its effects have yet to be elucidated. In this study, we investigated the actions of GH on steroidogenesis by rat granulosa cells isolated from early antral follicles by focusing on the ovarian bone morphogenetic protein (BMP) system. We found that GH suppressed FSH-induced estradiol production with reduction in aromatase expression and, in contrast, GH increased FSH-induced progesterone level with induction of steroidogenic acute regulatory protein, side chain cleavage cytochrome P450, and 3 beta-hydroxysteroid dehydrogenase. The effects of GH on steroidogenesis by granulosa cells were enhanced in the presence of the BMP antagonist noggin. Coculture of GH with oocytes did not alter GH regulation of steroidogenesis. Steroid production induced by cAMP donors was not affected by GH treatment and the GH effects on FSH-induced steroid production were not accompanied by changes in cAMP synthesis, suggesting that GH actions were not directly mediated by the cAMP-protein kinase A pathway. GH exerted synergistic effects on MAPK activation elicited by FSH, which regulated FSH-induced steroidogenesis. In addition, GH-induced signal transducer and activator of transcription phosphorylation was involved in the induction of IGF-I expression. GH increased IGF-I, IGF-I receptor, and FSH receptor expression in granulosa cells, and inhibition of IGF-I signaling restored GH stimulation of FSH-induced progesterone production, suggesting that endogenous IGF-I is functionally involved in GH effects on progesterone induction. BMP inhibited IGF-I effects that increased FSH-induced estradiol production with suppression of expression of the GH/IGF-I system, whereas GH/IGF-I actions impaired BMP-Sma and Mad related protein 1/5/8 signaling through down-regulation of the expression of BMP receptors. Thus, GH acts to modulate estrogen and progesterone production differentially through endogenous IGF-I activity in granulosa cells, in which GH-IGF-I interaction leads to antagonization of BMP actions including suppression of FSH-induced progesterone production. Mutual balance between GH/IGF-I and BMP signal intensities may be a key for regulating gonadotropin-induced steroidogenesis in growing follicles. (Endocrinology 153: 469-480, 2012)

    DOI: 10.1210/en.2011-1646

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  • Interactive Effects of Epidermal Growth Factor Receptor (EGFR) and Na+/Glucose Transporter 1 (SGLT-1) Inhibitors on Viability of Adrenocortical Tumor Cells.

    Takafumi Taguchi, Yasumasa Iwasaki, Mitsuru Nishiyama, Makoto Tsugita, Yoshinori Taniguchi, Mizuho Okazaki, Shuichi Nakayama, Toshihiro Takao, Fumio Otsuka, Yoshio Terada

    ENDOCRINE REVIEWS   31 ( 3 )   2010年6月

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    記述言語:英語   出版者・発行元:ENDOCRINE SOC  

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  • 肺動脈性肺高血圧症とBMPシステム異常 (特集 肺動脈性肺高血圧症--基礎研究と臨床の進歩) -- (発症に関する最新研究動向)

    大塚 文男

    日本臨床   66 ( 11 )   2083 - 90   2008年11月

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    記述言語:日本語   出版者・発行元:日本臨床社  

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    その他リンク: http://search.jamas.or.jp/link/ui/2008376655

  • Apparent mineralocorticoid excess manifested in an elderly patient with hypothyroidism. 査読 国際誌

    Inagaki K, Otsuka F, Otani H, Sato C, Miyoshi T, Ogura T, Makino H

    American Journal of Hypertension   20 ( 1 )   104 - 7   2007年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.amjhyper.2006.06.012

    Web of Science

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  • [Primary pulmonary hypertension].

    Fumio Otsuka, Hirofumi Makino

    Nihon rinsho. Japanese journal of clinical medicine   63 Suppl 10   450 - 7   2005年10月

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

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  • Differential effect of chronic inhibition of calcium channel and angiotensin II type 1-receptor on aldosterone synthesis in spontaneously hypertensive rats 査読

    F Otsuka, T Ogura, H Kataoka, M Kishida, M Takahashi, Y Mimura, T Yamauchi, H Makino

    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY   74 ( 3 )   125 - 136   2000年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    We have investigated the in vivo effect of chronic blockade of Ca2+-channels and angiotensin II type I (AT(1))-receptors on aldosterone (Aldo)-synthesis in the adrenal glands of spontaneously hypertensive rats (SHR). Male SHR were administered Ca2+-antagonist, amlodipine (10 mg/kg per day) or AT(1)-receptor-antagonist, TCV-116 (1 mg/kg per day) from 7 until 11 weeks of age. Systolic blood pressure (SBP) and heart rate (HR) were significantly higher in SHR than Wistar-Kyoto (WKY) rats. Both treatments resulted in equivalent and significant reduction in SEP in SHR. Aldo-secretion in SHR, which was significantly higher than in WKY rats, was profoundly suppressed by TCV-116 compared with amlodipine. Both treatments resulted in thickening of the tuna glomerulosa, which immunohistochemically contains Aldo, at the end of therapy. Competitive reverse transcription-polymerase chain reaction (RT-PCR) showed that CYP11A (P450scc) mRNA regulating the first step of Aldo-synthesis was significantly reduced from week 9 of age by amlodipine, and that CYP11A (P450aldo) mRNA regulating the last step of Aldo-synthesis was potently suppressed from 9 weeks of age by TCV-116. Our results indicate that chronic treatment with different antihypertensive agents directly modulates adrenocortical aldosterone synthesis in SHR in vivo via different mechanisms. (C) 2000 Elsevier Science Ltd. All rights reserved.

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  • Hiroo Hashimoto, Fumio Otsuka, Hiroko Yamasaki, Toru Okamoto, Tetsushi Aita, Norikuni Kawanaka, Masanaori Kawashima, Yoshitaka Morita, Naoki Kashihara, Masahiro Yamanura and Hirofumi Makino : A case manifesting systemic lupus erythematosus during the administration of bucillamine for rheumatoid Arthritis-Like symptoms.

    Clin. Rheumatol.   12   45-52   2000年1月

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    掲載種別:研究論文(学術雑誌)  

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  • Toshio Ogura, Kazuo Tobe, Yukari Mimura, Fumio Otsuka, Takayoshi Yamauchi, Ayumi Imai, Chiaki Tsukamoto, Yoshiaki Iwasaki and Kazuharu Matsuura: Testosterone modulates serum leptin concentrations in a male patient with hypothalamic hypogonadism

    J. Endocrinol. Invest.   23   246-250   2000年1月

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    掲載種別:研究論文(学術雑誌)  

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  • Fumio Otsuka, Zuxu Yao, Taek-hoo Lee, Shin Yamamoto, Gregory F. Erickson and Shunichi Shimasaki: Bone morphogenetic protein-15:identification of target cells and biological functions

    J. Biol. Chem.   275   39523-39528   2000年1月

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    掲載種別:研究論文(学術雑誌)  

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  • Toshio Ogura, Kazuharu Matsuura, Fumio Otsuka, Ayumi Imai, Chiaki Tsukamoto, Yukari Mimura, Yoshiki Iwasaki and Kazuo Tobe: Serum leptin correlates with serum uric acid but not serum testosterone in non-obese male adolescent

    Res. Commun. Mol. Pathol. Pharmacol.   107   55-64   2000年1月

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    掲載種別:研究論文(学術雑誌)  

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  • Kozo Hashimoto, Isao Nagano, Koichi Asaba, Mari Inoue, Tatsuya Nishioka, Toshihiro Takao, Takahito Nakajo, Takahisa Mori, Masahiro Kurisaka and Fumio Otsuka: Significant gene expression of insulin-like growth factor ? and proliferating cell nuclear antigen in a rapidly growing recurrent pituitary ACTH-secreting adenoma

    Horm. Res.   54   198-202   2000年1月

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    掲載種別:研究論文(学術雑誌)  

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  • Kiyoshi Morita, Fumio Otsuka, Toshio Ogura, Mamoru Takeuchi, Satoshi Mizobuchi, Takayoshi Yamauchi, Hirofumi Makino and Masahisa Hirakawa: Sevoflurane anesthesia causes a transient decrease in aquaporin-2 and impairment of urine concentration

    Br. J. Anaesth.   83   734-739   1999年1月

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    掲載種別:研究論文(学術雑誌)  

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  • Fumio Otsuka, Toshio Ogura, Nobuhiko Hayakawa, Seishi Harada, Jingo Kageyama and Hirofumi Makino: Reversible hypothyroidism in empty sella syndrome: a case report

    Endocr. J.   45   385-391   1998年1月

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    掲載種別:研究論文(学術雑誌)  

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  • Fumio Otsuka, Takayoshi Yamauchi, Hideo Kataoka, Yukari Mimura, Toshio Ogura and Hirofumi Makino: Effects of chronic inhibition of ACE and AT1 receptors on glomerular injury in Dahl salt-sensitive rats

    Am. J. Physiol.   274   R1797-R1806   1998年1月

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    掲載種別:研究論文(学術雑誌)  

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  • Kazushi Harada, Toshio Ogura, Takayoshi Yamauchi, Fumio Otsuka, Yukari Mimura, Masami Hashimoto, Tetsuya Oishi and Hirofumi Makino: Effect of continuous infusion of vasopressin on glomerular growth response in spontaneously hypertensive rats

    Regul. Rept.   4   11-18   1998年1月

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    掲載種別:研究論文(学術雑誌)  

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  • Naoko Asano, Toshio Ogura, Yukari Mimura, Masayuki Kishida, Hideo Kataoka, Fumio Otsuka, Takayoshi Ymauchi and Hirofumi Makino: Renal AT1 receptor: autoradiographic localization and quantification in rat

    Res. Commun. Mol. Pathol. Pharmacol.   100   161-170   1998年1月

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  • Naoko Asano, Toshio Ogura, Yukari Mimura, Fumio Otsuka, Masayuki Kishida, Masami Hashimoto, Takayoshi Yamauchi and Hirofumi Makino: Renal AT1 receptor: computerized quantification in spontaneously hypertensive rats and DOCA-salt rats

    Res. Commun. Mol. Pathol. Pharmacol.   100   171-180   1998年1月

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  • Fumio Otsuka, Jingo Kageyama, Toshio ogura, Teruhiko Hattori and Hirofumi makino: Sheehan''s syndrome more than 30 years in duration: an endocrine and MRI study in 6 cases

    Endocr. J.   45   451-458   1998年1月

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    掲載種別:研究論文(学術雑誌)  

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  • Fumio Otsuka, Fuyou Otsuka-Misunaga, Shiho Koyama, Hiroshi Yamanari, Toru Ohe, Toshio Ogura and Hirofumi Makino: Hormonal characteristics of primary hyperaldosteronism due to unilateral adrenocortical hyperplasia

    J. Endocrinol. Invest.   21   531-536   1998年1月

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    掲載種別:研究論文(学術雑誌)  

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  • Fumio Otsuka, Toshio Ogura, Takayoshi Yamauchi, Yukari Mimura and Hirofumi Makino: Effects of OPC-21268, a vasopressin V1-receptor antagonist, on glomerular injury in spontaneously hypertensive rats

    Regul. Rept.   72   87-95   1997年1月

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    掲載種別:研究論文(学術雑誌)  

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  • Fumio Otsuka, Satodhi Mizobuchi, Toshio Ogura, Kiyoshi Morita, Masahisa Hirakawa and Hirofumi Makino: Postanesthetic polyuria attributable to central diabetes insipidus

    Anesth. Analg.   85   940-943   1997年1月

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  • IDDM accompanied a growth hormone-producing pituitary adenoma: A case report 査読

    Fumio Otsuka, Toshio Ogura, Takayoshi Yamauchi, Kenichi Shikata, Jingo Kageyama, Hirofumi Makino

    Diabetes Care   20 ( 12 )   1838 - 1841   1997年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:American Diabetes Association Inc.  

    CASE HISTORY - A 30-year-old Japanese man who presented with recurrent ketoacidosis caused by IDDM was found to have increased secretion of growth hormone (GH). On initial cranial magnetic resonance imaging (MRI), no pituitary lesion was detected
    however, a pituitary microadenoma was found 2 years later during a repeat MRI. In spite of the hypersecretion of GH, serum IGF-I was dramatically suppressed. Transsphenoidal surgery was performed to resect the pituitary tumor that was histologically an acidophilic pituitary adenoma. Although the GH excess rapidly improved postoperatively, the IGF-I level remained low. Subsequent insulin therapy initiated 1 year after the operation elevated the serum IGF-I level to within the normal range. DISCUSSION - The first case of coexistent IDDM and a GH-producing pituitary adenoma suggests that patients with uncontrolled IDDM may develop GH hypersecretion. Furthermore, the low IGF-I levels may be closely associated with the GH excess and with the development or progression of GH-secreting pituitary adenomas.

    DOI: 10.2337/diacare.20.12.1838

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  • In vitro macro- and microautoradiographic localization of V1 and V2 receptors in the rat kidney using OPC-21268 and OPC-31260. 査読

    Yukari Mimura, Toshio Ogura, Nobuhiko Hayakawa, *Fumio Otsuka, Masami Hashimoto, Takayoshi Yamauchi, Hirofumi Makino and Norio Ogawa

    Nephron   76 ( 3 )   331 - 336   1997年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1159/000190200

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  • Toshio Ogura, Michio Takaoka, Takayoshi Yamauchi, Tetsuya Oishi, Yukari Mimura, Masami Hashimoto, Naoko Asano, Masahiro Yamamura, Fumio Otsuka, Hirofumi Makino, Zensuke Ota and Kayo Takahashi: Changes in urinary enzyme activity and histochemical findings in experimental tubular injury by gold sodium thiomalate

    J.Med.   27   41-55   1996年1月

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    掲載種別:研究論文(学術雑誌)  

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  • Fumio Otsuka, Yoshiko Hayashi, Toshio Ogura, Nobuhiko Hayakawa, Shuji Ikeda, Hirofumi Makino, and Zensuke Ota: Syndrome of inappropriate secretion of antidiuretic hormone following Intra-Thoracic cisplatin

    Intern.Med.   35   290-294   1996年1月

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    掲載種別:研究論文(学術雑誌)  

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  • Fumio Otsuka, Tetsuki Amano, Naoko Hashimoto, Maki Takahashi, Nobuhiko Hayakawa, Hirofumi Makino,Zensuke Ota and Toshio Ogura: Bronchiolitis organizing pneumonia associated with systemic lupus erythematosus with antiphospholipid antibody

    Intern. Med.   35   341-344   1996年1月

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  • Yukari Mimura, Toshio Ogura, Takayoshi Yamauchi, Fumio Otsuka, Tetsuya Oishi,Kazushi Harada,Masami Hashimoto and Zensuke Ota: Effect of vasopressin V1-and V2-receptor stimulation on blood pressure in DOCA-salt hypertensive rats

    Acta Med. Okayama   49   187-194   1995年1月

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    掲載種別:研究論文(学術雑誌)  

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  • Fumio Otsuka, Tetsuki Amano, Toshio Ogura and Zensuke Ota: Diabetes insipidus with Behcet''s disease

    lancet   364   1494-1495   1995年1月

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▼全件表示

書籍等出版物

  • 「はじめに:専門医とホスピタリストの対話から内分泌疾患を学ぶ」

    栗原 勲、大塚文男

    Hospitalist vol.9:no.2  2021年12月 

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    担当ページ:265-266   記述言語:日本語

    2021

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  • 「特集・内分泌疾患2」

    栗原 勲、大塚文男、小比賀美香子、鈴木利彦、藤谷茂樹

    Hospitalist vol.9:no.2  2021年12月 

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    記述言語:日本語

    2021

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  • General Mindで攻める総合内科で診る内分泌疾患

    大塚文男( 担当: 単著 ,  範囲: 終わりに:内分泌疾患を診るには総合力が不可欠!)

    中外医学社  2020年11月 

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    記述言語:日本語

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  • General Mindで攻める総合内科で診る内分泌疾患

    大塚文男( 担当: 単著 ,  範囲: 「中外医学社・General Mindで攻める総合内科で診る内分泌疾患」)

    中外医学社  2020年11月 

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    記述言語:日本語

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  • General Mindで攻める総合内科で診る内分泌疾患

    大塚文男( 担当: 単著 ,  範囲: 巻頭言:なぜ総合内科・総合診療で内分泌疾患か?)

    中外医学社  2020年11月 

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    記述言語:日本語

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  • General Mindで攻める総合内科で診る内分泌疾患

    大塚文男( 担当: 単著 ,  範囲: Chapter 1:内分泌疾患を想起すべき症状:疾患想起となるキー症状)

    中外医学社  2020年11月 

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    記述言語:日本語

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  • 内科学書第9版

    越智可奈子、大塚文男( 担当: 共著 ,  範囲: 視床下部の異常・視床下部疾患)

    中山書店  2019年8月 

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    担当ページ:28-33   記述言語:日本語

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  • 内科学書第9版

    藤澤 諭、大塚文男( 担当: 共著 ,  範囲: 視床下部の異常・視床下部の検査法)

    中山書店  2019年8月 

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    担当ページ:26-28   記述言語:日本語

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  • 内科学書第9版

    当真貴志雄、大塚文男( 担当: 共著 ,  範囲: 視床下部の異常・視床下部の構造と機能)

    中山書店  2019年8月 

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    担当ページ:23-26   記述言語:日本語

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  • Human Pathochiochemistry.

    Oohashi T, Tsukahara H, Ramirez F, Barber C, Otsuka F( 担当: 共著 ,  範囲: Human Pathochiochemistry.)

    springer nature  2019年3月 

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    記述言語:英語

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  • 特集・検査を病棟で上手に使おう

    原田 洸、西村義人、大塚文男( 担当: 共著 ,  範囲: 特集・検査を病棟で上手に使おう)

    羊土社  2019年3月 

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    記述言語:日本語

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  • 内分泌疾患の診断・鑑別:一般検査所見、胸腹部単純写真、心電図

    大塚文男、当真貴志雄( 担当: 共著)

    診断と治療社・内分泌代謝専門医研修ガイドブック  2018年5月 

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    記述言語:日本語

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  • 中枢性思春期早発症・低ゴナドトロピン性性腺機能低下症

    大塚文男( 担当: 単著)

    「医学書院:新臨床内科学第10版」  2018年4月 

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    記述言語:日本語

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  • TSH産生下垂体腺腫・ゴナドトロピン産生下垂体腺腫・非機能性下垂体腺腫

    大塚文男( 担当: 単著 ,  範囲: TSH産生下垂体腺腫・ゴナドトロピン産生下垂体腺腫・非機能性下垂体腺腫)

    朝倉書店・内科学 第11版  2017年3月 

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    記述言語:日本語

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  • 内分泌代謝専門医ガイドブック改訂第4版

    大塚文男、山内尚子( 担当: 共著 ,  範囲: 下垂体卒中)

    診断と治療社  2016年4月  ( ISBN:4787821571

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    担当ページ:148-149   記述言語:日本語

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  • 今日の診断指針第7版

    大塚文男( 範囲: プロラクチノーマProlactinoma)

    医学書院  2015年4月  ( ISBN:9784260020145

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    担当ページ:1197-1200   記述言語:日本語

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  • 認定医・専門医のための輸液・電解質・酸塩基平衡

    武田昌也、大塚文男、槇野博史( 担当: 共著 ,  範囲: 嘔気・嘔吐と全身倦怠感を訴える若年女性)

    中山書店  2013年6月 

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    担当ページ:172-173   記述言語:日本語

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  • BMPを用いた卵巣内分泌機能の評価指標の確立へ:第19回研究助成金研究業績」.

    大塚文男( 担当: 単著)

    公益財団法人黒住医学研究振興財団年報  2013年4月 

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    担当ページ:p27   記述言語:日本語

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  • 骨形成コントロールによるリウマチ性骨破壊抑止への挑戦.

    大塚文男( 担当: 単著)

    中富健康科学振興財団第24回研究助成業績集  2013年4月 

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    担当ページ:p1-3   記述言語:日本語

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  • 生物学に関する試験論叢

    大塚文男( 担当: 単著 ,  範囲: 内分泌調整のキーファクターBMP?その生理活性メカニズムの解明と生殖医療への応用?.)

    平成21年度両備檉園記念財団研究助成金による研究報告  2011年 

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    担当ページ:23-28   記述言語:日本語

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  • 平成20年度岡山医学会賞(砂田賞)受賞論文 副腎皮質細胞におけるアルドステロンブレイクスルー現象とBMP-6の関与.

    大谷寛之、大塚文男、槇野博史( 担当: 共著)

    岡山医学会雑誌  2010年 

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    記述言語:日本語

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  • 原発性肺高血圧症の分子病態の解明と応用:肺血管平滑筋細胞の増殖におけるBMPシステム異常の関与.

    大塚文男( 担当: 単著)

    第37回かなえ医薬振興財団助成金受賞者研究業績集  2010年 

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    記述言語:日本語

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  • 中冨健康科学振興財団第20回研究助成事業 平成21年版

    大塚文男( 担当: 単著)

    中冨健康科学振興財団  2009年 

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    記述言語:日本語

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  • 山口内分泌疾患研究振興協会研究報告書 平成13年度〜平成17年度

    大塚文男( 範囲: 卵母細胞因子BMP-15を用いた卵胞機能診断とその治療応用への可能性 ?BMPの生殖内分泌作用と臨床応用?.)

    2008年 

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    担当ページ:p137-142  

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  • (財)日本心臓血圧研究振興会 平成19年度研究業績集

    大塚文男、中村一文( 範囲: 原発性肺高血圧症の成因とBMPシグナル.)

    2008年 

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    担当ページ:p33-37  

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  • 看護大事典

    医学書院  2007年 

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  • 分かりやすい内科学 第3版

    大塚文男、景山甚郷( 範囲: 内分泌疾患:副腎皮質疾患、副腎髄質疾患)

    文光堂  2007年 

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  • 財団法人 テルモ科学技術振興財団

    大塚文男( 範囲: 2007年度 一般研究助成 研究実施報告書集)

    2007年 

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    担当ページ:p55-57  

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  • Annual Review 糖尿病・代謝・内分泌2007

    大塚文男( 範囲: BMP-15のpleiotropic actions ?特に生殖内分泌との関わり?)

    中外医学社  2007年 

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    担当ページ:159-168  

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  • 東京生化学研究会 助成研究報告集 平成17年度版(第20集)

    大塚文男( 範囲: 骨形成蛋白(BMP)による内分泌調節機構の解明?卵巣機能の調節とその病態治療への応用をめざして?)

    2006年 

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    担当ページ:pp84-91  

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  • 財団法人 循環器病研究振興財団 報告集

    大塚文男( 範囲: 原発性肺高血圧症の発症機序に迫る:肺高血圧の肺動脈血管平滑筋細胞を用いた異常増殖メカニズムの検討)

    2005年 

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    担当ページ:19-22  

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  • 助成金報告集(財)医薬資源研究振興会

    大塚文男( 範囲: 骨形成蛋白(BMP)を用いた卵巣機能障害に対する早期診断および治療応用への試み)

    2004年 

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    担当ページ:p46-49  

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  • (財)岡山医学振興会 年報No.3 2003

    大塚文男、小倉俊郎、武田昌也、鈴木二郎、稲垣兼一( 範囲: 骨形成蛋白(BMP)を用いた卵巣機能不全に対する臨床応用への試み)

    2004年 

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    担当ページ:p16  

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  • 化学と生物 42

    大塚文男( 範囲: 哺乳類卵巣におけるBMPシステムとその役割)

    2004年 

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    担当ページ:p104-113  

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  • 看護大事典

    医学書院  2002年 

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    著書種別:事典・辞書

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  • 看護大事典:副腎関連用語

    医学書院  2002年 

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    著書種別:事典・辞書

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  • わかりやすい内科学

    *大塚文男、景山甚郷( 範囲: アジソン病、原発性アルドステロン症、クッシング症候群、褐色細胞腫)

    文光堂  1999年 

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    担当ページ:679-700  

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  • 症候群事典:Sheehan症候群

    診断と治療社  1998年 

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    著書種別:事典・辞書

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  • 静脈疾患とリンパ管外科:深部静脈血栓症

    柚木継二、末広晃太郎、内田發三、*大塚文男、天野哲基、槇野博史、太田善介( 範囲: 特異な凝固異常が疑われた深部静脈血栓症の1例)

    アクセルシュプリンガー  1997年 

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    担当ページ:65-67  

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▼全件表示

MISC

  • 【COVID-19-その診断と治療】倦怠感

    大塚 勇輝, 徳増 一樹, 本多 寛之, 萩谷 英大, 大塚 文男

    カレントテラピー   39 ( 11 )   1034 - 1039   2021年11月

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    記述言語:日本語   出版者・発行元:(株)ライフメディコム  

    新型コロナウイルス感染症(COVID-19)が最初に報告されてからおよそ1年半が経過したが、いまだ収束の兆しの見えない世界的流行のなかで「Long-COVID」ないし「post-acute sequelae of COVID-19(PASC)」と定義され、一般には「コロナ後遺症」として知られる、急性期以降に残存する症状に悩まされる患者が多く存在している。そのなかでも「倦怠感」は、最も多い症状として報告され、COVID-19罹患後に4割程度の患者が自覚すると言われている。倦怠感は視認できず検査での客観的評価も難しい症状である一方で、さまざまな要因が複雑に絡みあって生じており病態メカニズムも未解明なところが多く、診療に難渋する。われわれは2021年2月にLong-COVID/PASCを専門的に診療する「コロナ・アフターケア(COVID-19 aftercare:CAC)外来」を大学病院内にいち早く設立し、倦怠感などの症状に悩む患者の診療と研究・教育に取り組んできた。本稿ではそうしたわれわれの診療経験も踏まえ、診断や治療を行ううえでの対面診療の必要性や総合診療的アプローチの重要性についても触れながら、Long-COVID/PASCにおける倦怠感について概説する。(著者抄録)

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  • COVID-19外国人入院診療の実際

    大塚 勇輝, 萩谷 英大, 中野 靖浩, 大村 大輔, 長谷川 功, 大塚 文男

    日本医師会雑誌   150 ( 7 )   1237 - 1241   2021年10月

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    記述言語:日本語   出版者・発行元:(公社)日本医師会  

    国際化を背景に、在日外国人も新型コロナウイルス感染症(COVID-19)に罹患しているが、本邦でその診療上の課題に関する文献はない。2020年2月からの1年間に岡山大学病院総合内科・総合診療科に入院した、外国人COVID-19患者全5人を対象として、患者背景や言語状況、入院中のトラブルや解決策について診療録から抽出した。全員が日本語の書字・読字が全く不能であり、うち1人は日常会話も困難で電話医療通訳サービスを要したが、担当医や看護師に加えて、国際診療支援センターや臨床栄養部、精神科などと連携することで隔離解除まで入院継続が可能であった。COVID-19では本人の希望に沿わない入院や予定外入院のため、通常の外国人診療に比して負担・課題が大きい。特に言語面での制約は、隔離管理下での意思疎通や同意書の取得などの面で障壁となることが明らかとなった。院内組織の連携と、病院を超えた情報共有による病軟な対応が重要である。(著者抄録)

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  • 高用量ステロイド治療が奏功した重症COVID-19妊婦の1例

    山本 紘一郎, 萩谷 英大, 牧 尉太, 岡原 修司, 長谷川 功, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   568 - 568   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 総合診療におけるカテコールアミン測定の有用性とその解釈

    砂田 匠彦, 花山 宜久, 灘 隆宏, 徳増 一樹, 山本 紘一郎, 中野 靖浩, 長谷川 功, 萩谷 英大, 小比賀 美香子, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   560 - 560   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 虹彩炎が治療導入の契機となった2型糖尿病の1例

    中本 健太, 本多 寛之, 平 佑貴, 庵谷 紘美, 中野 靖浩, 長谷川 功, 萩谷 英大, 小比賀 美香子, 片岡 仁美, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   555 - 555   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • COVID-19肺炎を発症した高Ca血症・肺病変を伴うMEN1の1例

    大塚 勇輝, 田中 秀一, 本多 寛之, 長谷川 功, 萩谷 英大, 小松原 基志, 岸田 雅之, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   548 - 548   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 心不全・肝不全から発見された高齢橋本病の1例

    上枝 礼佳, 山本 紘一郎, 田中 秀一, 孫 麗那, 本多 寛之, 長谷川 功, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   516 - 516   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 歯科受診を契機に発見された先端巨大症の1例

    中野 靖浩, 中本 健太, 平 佑貴, 庵谷 紘美, 長谷川 功, 三好 智子, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   505 - 505   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 抗PD-1抗体による早期の甲状腺障害後にACTH分泌不全を呈した1例

    安田 美帆, 山本 紘一郎, 中野 靖浩, 長谷川 功, 越智 可奈子, 三好 智子, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   503 - 503   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 肺非結核性抗酸菌症を合併したACTH分泌不全症の1例

    高瀬 了輔, 中野 靖浩, 山本 紘一郎, 越智 可奈子, 長谷川 功, 三好 智子, 小川 弘子, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   499 - 499   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • COVID-19後の後遺症が診断の契機となったLOH症候群の1例

    副島 佳晃, 中野 靖浩, 徳増 一樹, 大塚 勇輝, 櫻田 泰江, 本多 寛之, 中本 健太, 長谷川 功, 萩谷 英大, 植田 圭吾, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   496 - 496   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 炎症性動脈瘤を合併し仮面尿崩症を呈した下垂体機能低下症の1例

    平 佑貴, 中野 靖浩, 中本 健太, 庵谷 紘美, 長谷川 功, 萩谷 英大, 三好 智子, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   491 - 491   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 不明熱精査からirAEによるACTH単独欠損症と診断した2例

    平仲 凪, 山本 紘一郎, 田中 秀一, 孫 麗那, 高橋 美砂, 本多 寛之, 長谷川 功, 大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   488 - 488   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本内分泌学会  

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  • 内分泌疾患を見逃さないコツ

    大塚 文男

    日本内分泌学会雑誌   97 ( 2 )   465 - 465   2021年10月

    <