研究者詳細 - 塚原　宏一

MISC - 塚原　宏一

分割表示 415 件中 281 - 300 件目／全件表示 >>

新生児: 体液・電解質異常

塚原宏一

小児科診療（増刊号: 小児の治療指針） 69 861 - 867 2006年

乳幼児の尿路感染症の診断のポイント

塚原宏一

小児科 46 ( 13 ) 2133 - 2142 2005年12月

Transient focal lesions in the splenium of the corpus callosum with restricted diffusion: An enigma

M Maeda, H Tsukahara

CURRENT MEDICAL IMAGING REVIEWS 1 ( 3 ) 313 - 318 2005年11月

記述言語：英語掲載種別：書評論文，書評，文献紹介等出版者・発行元：BENTHAM SCIENCE PUBL LTD

Small transient lesions in the central part of the splenium of the corpus callosum (SCC) have been reported in MR examinations, particularly in patients with encephalitis or encephalopathy, and in patients with or without epilepsy who are receiving antiepileptic drugs. The MR findings are characteristic: an ovoid T2-high signal lesion in the SCC, no enhancement after contrast agent, restricted diffusion shown by diffusion MR imaging, and complete disappearance on follow-up MR examinations. Most noteworthy is that these lesions have restricted diffusion but are reversible, which is distinct from infarction lesions seen in energy failure. The exact mechanism of these transient lesions remains uncertain and enigmatic. We review previously reported patients to show these unique MR findings and describe possible pathogenesis of particular SCC lesions.

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Quantitation of glutathione S transferase-π in the urine of preterm neonates

H.Tsukahara, M.Toyooka, Y.Kanaya, K.Ogura, M.Kawatani, A.Hata, M.Hiraoka, M.Mayumi

Pediatr Int 47 ( 5 ) 528 - 531 2005年10月

PDTC and NO suppress CC chemokine production in TNF-α-stimulated human pulmonary microvascular endothelial cells

Y.Mori, H.Tsukahara, MZ.Jiang, M.Mayumi

Respir Med 99 ( 8 ) 1068 - 1069 2005年8月

Quantification of L-type fatty acid binding protein in the urine of preterm neonates

H Tsukahara, T Sugaya, K Hayakawa, Y Mori, M Hiraoka, A Hata, M Mayumi

EARLY HUMAN DEVELOPMENT 81 ( 7 ) 643 - 646 2005年7月

記述言語：英語出版者・発行元：ELSEVIER IRELAND LTD

We measured urinary excretion of L-type fatty acid binding protein (LFABP) in preterm neonates on days 1, 5-10, and 25-30 of life. Urinary L-FABP levels (expressed as the ratio to creatinine) in preterm neonates were considerably higher than those of healthy adults. They did not change significantly during the study period. Urinary L-FABP levels showed significant positive correlation with those of urinary N-acetyl-beta-D-glucosaminidase activity on day 1, and with those of 8-hydroxy-2'-deoxyguanosine on days 25-30. These results suggest that L-FABP is expressed in the neonatal kidney. Our results may also point to potential effects of proximal tubular damage and oxidative stress on urinary excretion of L-FABP. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.earlhumdev.2005.03.012

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Effects of antioxidants and NO on TNF-α-induced adhesion molecule expression in human pulmonary microvascular endothelial cells

MZ.Jiang, H.Tsukahara, K.Hayakawa, Y.Todoroki, S.Tamura, Y.Ohshima, M.Hiraoka, M.Mayumi

Respir Med 99 ( 5 ) 580 - 591 2005年5月

Parameters for measurement of oxidative stress in diabetes mellitus: Applicability of enzyme-linked immunosorbent assay for clinical evaluation

E Noiri, H Tsukahara

JOURNAL OF INVESTIGATIVE MEDICINE 53 ( 4 ) 167 - 175 2005年5月

記述言語：英語掲載種別：書評論文，書評，文献紹介等出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS

Investigations of the mechanisms involved in the onset and progression of diabetes have recently confronted the role of reactive oxygen species (ROS) and oxidative stress. Prolonged exposure to hyperglycemic conditions induces nonenzymatic glycation of protein via the so-called Maillard reaction, resulting in Schiff-base products and Amadori products that engender ROS production. These processes initiate and exacerbate micro- and macrovascular complications in diabetes. Increased oxidative stress is induced by excessive ROS production and inadequate antioxidant defenses. Recently, oxidative stress status markers have been associated directly with the severity and prognosis of diabetes. To examine oxidative stress, reliable and high-throughput methods are needed to examine large numbers of clinical samples. The emerging availability of enzyme-linked immunosorbent assay (ELISA) for oxidative stress status markers allows its application to assessment of various pathophysiologic conditions, including diabetes. This review outlines the recent achievements of ELISA application for clinical studies elucidating oxidative stress. It introduces the potential applicability of ELISA for investigating oxidative stress in diabetes.

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Salivary-type hyperamylasemia in theophylline poisoning

K Suzuki, Y Ohshima, Hata, I, H Tsukahara, N Omata, M Yasutomi, A Yamada, M Mayumi

PEDIATRICS INTERNATIONAL 47 ( 2 ) 209 - 210 2005年4月

Concentrations of thioredoxin, a redox-regulating protein, in umbilical cord blood and breast milk

Y Todoroki, H Tsukahara, Y Ohshima, K Shukunami, K Nishijima, F Kotsuji, A Hata, K Kasuga, K Sekine, H Nakamura, J Yodoi, M Mayumi

FREE RADICAL RESEARCH 39 ( 3 ) 291 - 297 2005年3月

記述言語：英語出版者・発行元：TAYLOR & FRANCIS LTD

Growing evidence indicates that oxidative stress occurs during the fetal-to-neonatal transition. Such stress plays an important role in the pathogenesis of many neonatal diseases. Thioredoxin (TRX), a redox-regulating protein with antioxidant activity, is induced in various cells against oxidative stress and is secreted extracellularly. This study was undertaken to examine the clinical and biological importance of TRX in the perinatal setting. We measured concentrations of TRX in umbilical cord blood and breast milk using a sandwich ELISA. Our study demonstrated that concentrations of TRX in umbilical cord blood were six to seven times higher than those in blood of healthy adults. This study also showed that umbilical concentrations of TRX were correlated significantly with the extent of prematurity of the newborn, and that they were elevated significantly in newborns of mothers with preeclampsia compared to those of mothers without preeclampsia. In contrast, concentrations of coenzyme Q(10) and vitamin E in umbilical blood were lower than adult blood levels. Breast milk concentrations of TRX during the early postpartum period were seven to eight times higher than those in blood of lactating women. Those of the coenzyme Q(10) were lower than adult blood levels, while those of vitamin E were comparable to adult blood levels. Our findings suggest that the systemic release of TRX is enhanced at birth, and that early breast milk is a rich source of this protein. Consequent high levels of TRX in newborns may provide a unique protective mechanism that allows the maintenance of redox balance during the fetal-to-neonatal transition.

DOI： 10.1080/10715760500053578

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Marked renal damage in a child with hydronephrosis infected by Trichosporon asahii

Y Mori, M Hiraoka, M Katsu, H Tsukahara, Y Mikami, M Mayumi

PEDIATRIC NEPHROLOGY 20 ( 2 ) 234 - 236 2005年2月

記述言語：英語出版者・発行元：SPRINGER

We describe a case of urinary infection caused by Trichosporon asahii, which drastically aggravated renal function in a left hydronephrotic kidney. Previous implantation of a nephrostomy tube and a ureteral J-stent and administration of broad-spectrum antibiotics seemed to have predisposed the non-granulocytopenic child to the urinary fungal infection.

DOI： 10.1007/s00467-004-1731-6

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Conservative versus extirpative management in cases of placenta accreta

K Nishijima, K Shukunami, H Tsukahara, F Kotsuji

OBSTETRICS AND GYNECOLOGY 105 ( 1 ) 220 - 220 2005年1月

早産児の代謝性骨疾患

塚原宏一

周産期医学 35 1671 - 1679 2005年

会報編集委員会: 報告と編集後記

橋本剛太郎, 加藤英治, 清水紘昭, 塚原宏一, 寺尾正

平成17年度福井県小児科医会会報 34(10) 2005年

栄養補助物質の使用: ビタミンの補充

塚原宏一, 塚原康代

周産期医学 35(増刊号) 474 - 483 2005年

周産期のレドックス制御: 特に母乳の抗酸化作用の分析についての研究

塚原宏一

2003年度財団法人森永奉仕会研究奨励金成果報告書 2005年

ペプチド分解乳で牛乳アレルギーの予防ができるのか？母乳はアトピー性皮膚炎に良くないのか？

塚原宏一, 大嶋勇成

小児内科 37(5) ( 5 ) 677 - 680 2005年

免疫・炎症性疾患におけるレドックス・マーカーの現況

塚原宏一

臨床病理 53(8) 759 - 767 2005年

生直後に著明な赤芽球増加,低血糖を呈した胎児水腫の極低出生体重児例

小倉一将, 塚原宏一, 巨田尚子, 佐藤周子, 古畑律代, 田村知史, 谷澤昭彦, 眞弓光文

小児科臨床 58 ( 8 ) 1691 - 1695 2005年

Quantitative unspun-urine microscopy as a quick, reliable examination for bacteriuria

M Hiraoka, Y Hida, Y Mori, H Tsukahara, Y Ohshima, H Yoshida, M Mayumi

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION 65 ( 2 ) 125 - 132 2005年

記述言語：英語出版者・発行元：TAYLOR & FRANCIS AS

The diagnosis and treatment of urinary infection are often delayed, causing renal damage, largely because of the unavailability of quick, accurate, diagnostic examinations. Three hundred and twenty-five urine samples from 130 patients were examined for significant bacteriuria using the standard culture method. The urine samples were also examined using the Gram-stain method and quantitative unspun-urine microscopy. When particles could not be distinguished definitely as bacilli by quantitative microscopy, the unspun urine was examined on a slide glass using oil-immersion microscopy at x 1000 magnification. Significant bacteriuria in 37 urine samples was detected by bacterial culture. Using quantitative microscopy, rods were found in 30, cocci in a chain in 3, and indefinite particles in 44 samples. In the 44 indefinite samples, oil-immersion microscopy was able to distinguish rods in one, cocci in a chain in one, cocci in a cluster in two, and negative in 40, which were confirmed by culture as rods, streptococci, staphylococci, and negative, respectively. The quantitative microscopy method was similarly reliable (94.6% sensitivity, 99.3% specificity) for diagnosis of significant bacteriuria when compared with the Gram-stain method (89.2% sensitivity, 98.6% specificity). Quantitative unspun-urine microscopy, confirmed by oil-immersion, is a quick, reliable method for diagnosis of significant bacteriuria, and is considered to be useful for early diagnosis of urinary infection.

DOI： 10.1080/00365510510013514

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