論文 - 塚原　宏一

Improved Bone Mineral Status in Very Low Birthweight Infants Fed Human Milk Mixed with Preterm Formula 査読

Hirokazu Tsukahara, Izuru Mitsuyoshi, Tadahiko Sakaguchi, Hitoo Fukuhara, Shuhei Hayashi, Katsuji Nakamura

Pediatrics International   31 ( 1 )   58 - 64   1989年

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

The bone mineral status of very low birthweight (VLBW) infants fed exclusively their own mother's milk (group I) was compared with that of VLBW infants fed mother's milk in the initial 4 weeks followed by a 1:1 mixture of mother's milk and preterm formula containing high phosphorus (P) and calcium (Ca) (group II). In both groups, most infants showed a biochemical picture characteristic of phosphorus deficiency syndrome by the fourth week. Thereafter, serum alkaline phosphatase activity (ALP) decreased and serum P increased in all group II infants. Conversely, serum ALP rose and hypophosphatemia persisted in most group I infants. Group II had a significantly higher serum P at weeks 8 and 12 and a significantly lower ALP at week 12 than group I. Furthermore, group II had a lower incidence of severe radiographic abnormalities than group I at week 12. We confumed previous observations that VLBW infants fed exclusively human milk require P and Ca supplementation to prevent metabolic bone disease of prematurity. Copyright © 1989, Wiley Blackwell. All rights reserved

DOI： 10.1111/j.1442-200X.1989.tb01270.x

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Mean Cellular Volume of Urinanry Red Blood Cells in Investigation of Hematuria 査読

Hirokazu Tsukahara, Masahiro Yoshimoto, Kiyoshi Morikawa, Toshiharu Okada, Mitsuhiko Kuroda, Masakatsu Sudo

Pediatrics International   31 ( 4 )   476 - 479   1989年

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

The mean cellular volume (MCV) of urinary red blood cells (RBCs) of pediatric patients with glomerular (group I
n = 52) and nonglomerular (group II
n = 21) hematuria was determined using an automated bloodell analyzer. Group I patients had a significantly lower MCV than group II (61 ± 8 w. 88 ± 15 μm3, mean ± SD
p&lt
0.001). With a MCV of 75 μm3 taken as the dividmg line between glomerular and nonglomerular hematuria, correct assessment of the site of bleeding was made in 67 of the 73 (92%) patients studied. Determination of the MCV of urinary RBCs is a simple noninvasive test for localizing the site of hemaw in pediatric patients. Copyright © 1989, Wiley Blackwell. All rights reserved

DOI： 10.1111/j.1442-200X.1989.tb01335.x

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Haemolytic uraemic syndrome associated with Yersinia enterocolitica infection

Hirokazu Tsukahara, Syuhei Hayashi, Katsuji Nakamura, Yasuyuki Nomura, Masahiro Yoshimoto, Shinichi Fujisawa

Pediatric Nephrology   2 ( 3 )   309 - 311   1988年9月

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Springer-Verlag  

Haemolytic uraemic syndrome (HUS) associated with Yersinia enterocolitica gastroenteritis is reported in a 6-year-old girl. Y. enterocolitica of biotype 03 was isolated from the patient's initial stool sample and was subsequently identified as serotype 03 based on the rising agglutinin titres. This paper shows that yersiniosis should be suspected as a possible cause of HUS, and investigations should include the measurement of serum agglutinin titres against antigen preparations of the genus Yersinia. © 1988 IPNA.

DOI： 10.1007/BF00858683

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Phosphorus Deficiency Syndrome in Two Very Low Birthweight Infants 査読

Hirokazu Tsukahara, Tadahiko Sakaguchi, Izuru Mitsuyoshi, Hitoo Fukuhara, Shuhei Hayashi, Katsuji Nakamura

Pediatrics International   30 ( 4 )   520 - 525   1988年

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Biochemical and radiographic abnormalities linked with phosphorus deficiency syndrome (PDS) developed in two very low birthweight (VLBW) infants fed exclusively with human milk. By increasing phosphorus (P) and calcium (Ca) intakes with the introduction of a specialized premature formula, osteopenia or rickets, as well as hypophosphatemia, hypo‐phosphaturia and increased serum alkaline phosphatase levels improved in both patients. We speculated that all VLBW infants who are being fed exclusively with human milk should be monitored for PDS and that if PDS develops, supplementation of human milk with both P and Ca appears to be necessary for its treatment. Copyright © 1988, Wiley Blackwell. All rights reserved

DOI： 10.1111/j.1442-200X.1988.tb02546.x

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