研究者詳細 - 岩室　雅也

論文 - 岩室　雅也

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Diagnostic accuracy of endoscopic biopsies for the diagnosis of gastrointestinal follicular lymphoma: a clinicopathologic study of 48 patients 査読

Masaya Iwamuro, Hiroyuki Okada, Katsuyoshi Takata, Soichiro Nose, Katsuya Miyatani, Tadashi Yoshino, Kazuhide Yamamoto

ANNALS OF DIAGNOSTIC PATHOLOGY 18 ( 2 ) 99 - 103 2014年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCIENCE INC

The purpose of this study was to reveal the diagnostic accuracy of initial pathologic assessment of biopsied samples in patients with gastrointestinal follicular lymphoma lesions. A total of 48 patients with follicular lymphoma (Lugano system stage I: n = 30; II1: n = 4; II2: n = 4; IV: n = 10) with gastrointestinal involvement who underwent endoscopic biopsy were enrolled and retrospectively reviewed. Nine (18.8%) of the 48 patients were not appropriately diagnosed as having follicular lymphoma at the initial biopsy. The initial pathological diagnosis included extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (n = 4), necrotic tissue (n = 2), duodenitis (n = 1), or suspected lymphoma of unspecified subtype (n = 2). The reasons for these inappropriate diagnoses were insufficient histopathologic analysis lacking CD10 and BCL2 staining (n = 7) and unsuitable biopsy samples taken from erosions or ulcers that contained scanty lymphoma cells or no lymphoid follicles (n = 2). In conclusion, incomplete histopathologic analysis and unsuitable biopsy samples are pitfalls in the diagnosis of gastrointestinal follicular lymphoma. (c) 2014 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.anndiagpath.2013.12.006

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Regression of metastatic colon tumour from primary adenocarcinoma of the lung due to fistulisation to the bowel lumen 査読

Masaya Iwamuro, Yoshio Miyabe, Hanae Kai, Yoshinari Kawai, Katsuyoshi Takata, Toshi Murakami, Hirofumi Mifune, Kazuhide Yamamoto

ecancermedicalscience 8 ( 1 ) 2014年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：European Institute of Oncology

An 80-year-old Japanese male was diagnosed with pulmonary adenocarcinoma. The patient exhibited extensive extra pulmonary involvement in the bone, adrenal gland, abdominal lymph nodes, and sigmoid colon. A single course of chemotherapy with carboplatin and pemetrexed was administered as the first-line treatment. Subsequently, the patient received pemetrexed monotherapy. Two months after the diagnosis, rapid regression of the metastatic tumour in the sigmoid colon was observed. Based on the findings of CT scanning and colonoscopic examination, tumour-bowel fistulisation was considered to be a cause of the rapid regression. This case report illustrates a tumour-bowel fistula of a colonic metastatic tumour in a patient with lung cancer. Radiographic and endoscopic features of the rare manifestation are presented. © the authors
licensee ecancermedicalscience.

DOI： 10.3332/ecancer.2014.412

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Elevated soluble IL-2 receptor levels correlate with tumor bulk of follicular lymphomas with intestinal involvement 査読

Masaya Iwamuro, Katsuji Shinagawa, Hiroyuki Okada, Katsuyoshi Takata, Tadashi Yoshino, Kazuhide Yamamoto

CLINICAL BIOCHEMISTRY 47 ( 3 ) 191 - 195 2014年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD

Objectives: Establish a correlation between serum soluble interleukin 2 receptor (sIL-2R) levels and clinical characteristics of follicular lymphoma patients with gastrointestinal involvement.
Design and methods: Patients (n = 44) presenting with follicular lymphoma lesions in the gastrointestinal tract were enrolled into the study and divided into 2 groups based on sIL-2R levels (normal vs. elevated). Clinical characteristics were also analyzed between groups.
Results: Patients with elevated sIL-2R levels likely had systemic follicular lymphoma involvement (Ann Arbor system staging IIIES/IV or Lugano system staging II-2/IV), involvement of 5 or more nodal areas, and presentation of bulky tumors in the gastrointestinal tract. These patients also presented a high Follicular Lymphoma International Prognostic Index (FLIPI) score, suggestive of poor prognosis. No differences were found among other clinical characteristics including sex, age at lymphoma diagnosis, histological grade, LDH levels, bone marrow involvement, hemoglobin levels, and identification of tracer accumulation in gastrointestinal lesions by positron-emission tomography scanning.
Conclusions: sIL-2R levels can be used as an independent prognostic index in follicular lymphoma patients based on the correlation with the FLIPI score. Moreover, since high sIL-2R levels were associated with a large tumor bulk, sIL-2R may serve as a good indicator for monitoring disease relapse or progression. (C) 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

DOI： 10.1016/j.clinbiochem.2013.11.026

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In Vitro Analysis of Gastric Phytobezoar Dissolubility by Coca-Cola, Coca-Cola Zero, Cellulase, and Papain 査読

Masaya Iwamuro, Yoshinari Kawai, Hidenori Shiraha, Akinobu Takaki, Hiroyuki Okada, Kazuhide Yamamoto

JOURNAL OF CLINICAL GASTROENTEROLOGY 48 ( 2 ) 190 - 191 2014年2月

Generation of Hepatocyte-like Cells from Human Induced Pluripotent Stem (iPS) Cells By Co-culturing Embryoid Body Cells with Liver Non-parenchymal Cell Line TWNT-1 査読

M. Shahid Javed, Naeem Yaqoob, Masaya Iwamuro, Naoya Kobayashi, Toshiyoshi Fujiwara

JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN 24 ( 2 ) 91 - 96 2014年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：COLL PHYSICIANS & SURGEONS PAKISTAN

Objective: To generate a homogeneous population of patient-specific hepatocyte-like cells (HLCs) from human iPS cells those show the morphologic and phenotypic properties of primary human hepatocytes.
Study Design: An experimental study.
Place and Duration of Study: Department of Surgery, Okayama University, Graduate School of Medicine, Japan, from April to December 2011.
Methodology: Human iPS cells were generated and maintained on ES qualified matrigel coated plates supplemented with mTeSR medium or alternatively on mitotically inactivated MEF feeder layer in DMEM/F12 medium containing 20% KOSR, 4ng/ml bFGF-2, 1 x 10(-4) M 2-mercaptoethanol, 1 mmol/L NEAA, 2mM L-glutamine and 1% penicillin-streptomycin. iPS cells were differentiated to HLCs by sequential culture using a four step differentiation protocol: (I) Generation of embryoid bodies (EBs) in suspension culture; (II) Induction of definitive endoderm (DE) from 2 days old EBs by growth in human activin-A (100 ng/ml) and basic fibroblasts growth factor (bFGF2) (100 ng/ml) on matrigel coated plates; (III) Induction of hepatic progenitors by co-culture with non-parenchymal human hepatic stellate cell line (TWNT-1); and (IV) Maturation by culture in dexamethasone. Characterization was performed by RT-PCR and functional assays.
Results: The generated HLCs showed microscopically morphological phenotype of human hepatocytes, expressed liver-specific genes (ASGPR, Albumin, AFP, Sox17, Fox A2), secreted human liver-specific proteins such as albumin, synthesized urea and metabolized ammonia.
Conclusion: Functional HLCs were generated from human iPS cells, which could be used for autologus hepatocyte transplantation for liver failure and as in vitro model for determining the metabolic and toxicological properties of drug compounds.

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Fermented persimmon extract (kaki-shibu) is useful as a standard for component analyses of persimmon phytobezoars 査読

Masaya Iwamuro, Yuko Okamoto, Toshihiro Murata, Yoshinari Kawai, Hidenori Shiraha, Hiroyuki Okada, Kazuhide Yamamoto

Okayama Igakkai Zasshi (Journal of Okayama Medical Association) 126 ( 2 ) 127 2014年

Regression of Duodenal Follicular Lymphoma: Susceptible to H-pylori Eradication? 査読

Masaya Iwamuro, Hiroyuki Okada, Katsuji Shinagawa, Katsuyoshi Takata, Tadashi Yoshino, Kazuhide Yamamoto

INTERNAL MEDICINE 53 ( 12 ) 1397 - 1397 2014年

Rapidly Progressed Primary Intestinal Follicular Lymphoma with Elevation of Soluble Interleukin-2 Receptor Levels 査読

Masaya Iwamuro, Ryuta Takenaka, Atsushi Mori, Shigeatsu Fujiki, Takayoshi Miyake, Shoji Asakura, Hiroyuki Okada, Katsuyoshi Takata, Tadashi Yoshino, Kazuhide Yamamoto

Case Reports in Oncological Medicine 2014 1 2014年

Reactive Lymphoid Hyperplasia with a Lipomatous Component Associated with Fecal Compaction in an Appendiceal Orifice 査読

Masaya Iwamuro, Yoshinari Kawai, Katsuyoshi Takata, Yoshio Miyabe, Hiroyuki Okada, Kazuhide Yamamoto

INTERNAL MEDICINE 53 ( 10 ) 1049 - 1053 2014年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC INTERNAL MEDICINE

A 69-year-old man underwent endoscopic mucosal resection of a solitary polyp located in the cecum. After the procedure, a fecal mass and appendiceal orifice appeared under the cut surface. A diagnosis of reactive lymphoid hyperplasia was made based on the results of an immunostaining analysis, which revealed a segregated population of T cells and B cells in multiple lymphoid follicles. The aggregation of adipocytes forming a lipomatous area and granulation tissue was also observed. We speculate that the compaction of the fecal mass in the appendix triggered mucosal inflammation, resulting in the formation of the polyp, which concealed both the feces and appendiceal orifice.

DOI： 10.2169/internalmedicine.53.1635

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Clinical Characteristics and Treatment Outcomes of Nineteen Japanese Patients with Gastrointestinal Bezoars 査読

Masaya Iwamuro, Shouichi Tanaka, Junji Shiode, Atsushi Imagawa, Motowo Mizuno, Shigeatsu Fujiki, Tatsuya Toyokawa, Yuko Okamoto, Toshihiro Murata, Yoshinari Kawai, Daisuke Tanioka, Hiroyuki Okada, Kazuhide Yamamoto

INTERNAL MEDICINE 53 ( 11 ) 1099 - 1105 2014年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC INTERNAL MEDICINE

Objective To analyze the clinical characteristics of patients with gastrointestinal bezoars and their response to therapy.
Patients We retrospectively reviewed the cases of 19 patients diagnosed with gastrointestinal bezoars at the Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences or one of 15 collaborating institutions between December 2004 and August 2013. We investigated the epidemiology and etiology of the gastrointestinal bezoars by determining the gender, age at diagnosis, medical history, symptoms, complications, modalities used for diagnosis, treatments, outcomes and bezoar location, color and contents.
Results There were 17 patients with gastric bezoars and two patients with small intestinal bezoars. All patients were 62 years of age or older, except for one case of a trichobezoar in a 10-year-old patient. Some of the patients had a history of surgery of any part of the gastrointestinal tract (n=5) and/or diabetes mellitus (n=2). The two patients with small intestinal bezoars required surgical removal in order to relieve ileus. Approximately one-half of the patients with gastric bezoars had ulcerations in the stomach (9/17 patients, 52.9%) and/or gastrointestinal bleeding (8/17, 47.1%). Endoscopic fragmentation was performed in 10 patients, whereas bezoar dissolution was achieved with a gastroprokinetic agent (n=1) and without any treatment (n=3) in the remaining cases.
Conclusion As previously reported, elderly individuals with a positive history of surgery and/or diabetes mellitus were observed in this bezoar patient series. Gastric ulcers and gastrointestinal bleeding were frequently observed. The majority of patients underwent endoscopic fragmentation, while spontaneous resolution of the gastric bezoar was observed in several cases.

DOI： 10.2169/internalmedicine.53.2114

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Corrigendum to "Loss of runt-related transcription factor 3 induces gemcitabine resistance in pancreatic cancer" [Mol. Oncol. 7, (2013), 840-849] 査読

Shigeru Horiguchi, Hidenori Shiraha, Teruya Nagahara, Jyunnro Kataoka, Masaya Iwamuro, Minoru Matsubara, Shinichi Nishina, Hironari Kato, Akinobu Takaki, Kazuhiro Nouso, Takehiro Tanaka, Koichi Ichimura, Takahito Yagi, Kazuhide Yamamoto

Molecular Oncology 8 ( 5 ) 1054 2014年

Indications for Colonoscopy in Patients with Systemic Lupus Erythematosus 査読

Masaya Iwamuro, Hiroyuki Okada, Jun Kato, Takehiro Tanaka, Ken-Ei Sada, Hirofumi Makino, Kazuhide Yamamoto

HEPATO-GASTROENTEROLOGY 60 ( 128 ) 1940 - 1944 2013年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：H G E UPDATE MEDICAL PUBLISHING S A

Background/Aims: Systemic lupus erythematosus is a systemic autoimmune disorder that sometimes involves the gastrointestinal tract. The aim of this study is to describe the clinical characteristics of patients with systemic lupus erythematosus with colorectal involvement, and to provide criteria for colonoscopy. Methodology: Among 288 patients with systemic lupus erythematosus, 29 patients underwent colonoscopy. The clinical backgrounds were comparatively analyzed between the patients with colorectal involvements (n = 11, group A) and the patients without colorectal involvements (n = 18, group B). Endoscopic features were also evaluated in group A patients. Results: The Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) of the group A patients was higher than that of the group B patients. Abdominal pain (n = 6) and diarrhea (n = 5) were significantly correlated with the presence of colorectal involvements, and other manifestations in group A patients included visible blood in stools (n = 5) and fever (n = 1). In colonoscopy, discrete ulcers (n = 5), longitudinal ulcers (n = 1), erosions and/or small ulcers (n = 2), edematous mucosa (n = 2), and concurrent ulcerative colitis (n = 1) were identified. Conclusions: Patients with systemic lupus erythematosus with SLEDAI scores >= 5, or with gastrointestinal symptoms, particularly those who present with abdominal pain or diarrhea should undergo colonoscopy, because these patients are likely to have mucosal damage in the colorectum.

DOI： 10.5754/hge.11013

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マントル細胞リンパ腫における十二指腸病変の内視鏡像の検討

岩室雅也, 岡田裕之, 守都敏晃, 川野誠司, 那須淳一郎, 河原祥朗, 高田尚良, 吉野正, 山本和秀

日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy 55 ( 8 ) "2167 - 74" 2013年8月

記述言語：日本語出版者・発行元：Japan Gastroenterological Endoscopy Society

【背景・目的】マントル細胞リンパ腫はしばしば消化管に浸潤し，多発性のポリープ状隆起を形成するが，十二指腸病変の肉眼型について詳細に検討した報告はない．今回われわれはマントル細胞リンパ腫における十二指腸病変について検討した．<BR>【方法】十二指腸浸潤を伴うマントル細胞リンパ腫の11例を対象とし，臨床背景および内視鏡像について検討した．<BR>【結果】十二指腸病変はいずれも隆起性病変を呈し，うち6例ではmultiple lymphomatous polyposisを形成していた．また隆起性病変の形態を細分すると，小ポリープ集簇3例，疣状3例，疣状病変と小ポリープ集簇病変の両者の混在2例，粘膜下腫瘍様3例であり，小ポリープ集簇病変ではいずれもびらんを認めなかったが，粘膜下腫瘍様隆起病変および疣状病変は1例を除く全症例でびらんを伴っていた．<BR>【結論】上記の病変を十二指腸に認めた場合には，マントル細胞リンパ腫の可能性を念頭に置き，生検診断を行うべきであると考えられた．

DOI： 10.11280/gee.55.2167

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その他リンク： http://search.jamas.or.jp/link/ui/2013373163

Magnifying Endoscopy for Intestinal Follicular Lymphoma Is Helpful for Prompt Diagnosis 査読

Masaya Iwamuro, Masato Okuda, Eiichiro Yumoto, Seiyuu Suzuki, Atsuko Shirakawa, Katsuyoshi Takata, Tadashi Yoshino, Hiroyuki Okada, Kazuhide Yamamoto

GUT AND LIVER 7 ( 2 ) 258 - 261 2013年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：EDITORIAL OFFICE GUT & LIVER

The representative endoscopic features of primary intestinal follicular lymphoma are well known as small whitish polypoid nodules, but a magnified view has only been described in a few case reports. Herein, we report a case with intestinal follicular lymphoma in which magnifying endoscopy with narrow band imaging was helpful for prompt diagnosis. A 57-year-old Japanese woman underwent surveillance esophagogastroduodenoscopy. The endoscopic examination revealed confluent whitish granules in the duodenum, distinct from the nodules or polyps that are typical findings of intestinal follicular lymphoma. Magnifying endoscopy visualized whitish enlarged villi, and narrow band imaging emphasized an elongated and coiled vascular pattern. Based on these features, intestinal follicular lymphoma was highly suspected, and subsequent histological study confirmed the diagnosis. This case demonstrates that magnifying endoscopy with narrow band imaging was useful for the detection and prompt diagnosis of intestinal follicular lymphoma. The pathological features of intestinal follicular lymphoma are also discussed. (Gut Liver 2013;7:258-261)

DOI： 10.5009/gnl.2013.7.2.258

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Primary intestinal follicular lymphoma: How to identify follicular lymphoma by routine endoscopy. 査読国際誌

Masaya Iwamuro, Yoshinari Kawai, Katsuyoshi Takata, Seiji Kawano, Tadashi Yoshino, Hiroyuki Okada, Kazuhide Yamamoto

World journal of gastrointestinal endoscopy 5 ( 1 ) 34 - 8 2013年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Baishideng Publishing Group Inc.

A 69-year-old Japanese female was diagnosed with primary intestinal follicular lymphoma. Esophagogastroduodenoscopy with high-definition imaging revealed not only the typical feature of whitish polyps of up to 2 mm in diameter in the duodenal second and third portions, but also more detailed morphology, such as enlarged whitish villi and tiny whitish depositions. These findings appeared to reflect the pathological structures; infiltration of lymphoma cells into the villi were probably seen as enlargement of the villi, and the formation of lymphoid follicles were shown as opaque white spots or tiny white depositions. Thus, the above features might contribute to the distinct diagnosis of intestinal follicular lymphoma. This case indicates that routine esophagogastroduodenoscopy can visualize microsurface structures, which can be pathognomonic and help to diagnose intestinal follicular lymphoma, even without magnifying endoscopy.

DOI： 10.4253/wjge.v5.i1.34

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Prospects for Creating Bioartificial Liver System with Induced Pluripotent Stem Cell Technology 査読

Masaya Iwamuro, Hidenori Shiraha

Journal of Biotechnology & Biomaterials 3 ( 2 ) 2013年

Precursor B Lymphoblastic Lymphoma Involving the Stomach 査読

Masaya Iwamuro, Yoshinari Kawai, Yasuhide Yamawaki, Katsuyoshi Takata, Kazuhide Yamamoto

Case Reports in Gastrointestinal Medicine 2013 1 2013年

Observation of lymphangioma of the duodenum by a magnifying endoscope with a narrow-band imaging system 査読

Masaya Iwamuro, Yoshinari Kawai, Katsuyoshi Takata, Hiroyuki Okada, Kazuhide Yamamoto

Case Reports in Gastroenterology 7 ( 2 ) 229 - 233 2013年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：S. Karger AG

Among duodenal tumors, lymphangioma is relatively infrequent. In this case report, we describe the case of a 65-year-old Japanese man with duodenal lymphangioma diagnosed by esophagogastroduodenoscopy. Endoscopically, the tumor appeared as a soft submucosal tumor with white spots. When the white spots were grasped by biopsy forceps, milky liquid exuded from the tumor. Additionally, observation by a magnifying endoscope with narrow-band imaging revealed elongated microvessels on the surface. We speculated that this feature was formed because the duodenal villi were dilated and the microvessels were stretched due to the retention of chyle. These endoscopic findings are key features in the diagnosis of duodenal lymphangioma.

DOI： 10.1159/000351831

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Synchronous Adenocarcinoma and Follicular Lymphoma of the Stomach 査読

Masaya Iwamuro, Atsushi Imagawa, Naruyuki Kobayashi, Yoshitsugu Kubota, Katsuya Miyatani, Katsuyoshi Takata, Hiroyuki Okada

INTERNAL MEDICINE 52 ( 8 ) 907 - 912 2013年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPAN SOC INTERNAL MEDICINE

A 73-year-old Japanese man with synchronous follicular lymphoma and adenocarcinoma of the stomach underwent curative surgical resection. The follicular lymphoma lesion was preoperatively diagnosed as extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) according to biopsy samples. However, postoperative pathological evaluations revealed components of CD10-positive and CD10-negative lymphoma cells within the lymphoma lesion. This case highlights the potential difficulty of diagnosing gastric follicular lymphoma. In such cases, conducting repeat pathological examinations of biopsy samples or resected specimens is required to obtain a correct diagnosis of follicular lymphoma.

DOI： 10.2169/internalmedicine.52.7948

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A preliminary study for constructing a bioartificial liver device with induced pluripotent stem cell-derived hepatocytes 査読

Masaya Iwamuro, Hidenori Shiraha, Shuhei Nakaji, Masumi Furutani, Naoya Kobayashi, Akinobu Takaki, Kazuhide Yamamoto

BIOMEDICAL ENGINEERING ONLINE 11 ( 1 ) 93 2012年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BIOMED CENTRAL LTD

Background: Bioartificial liver systems, designed to support patients with liver failure, are composed of bioreactors and functional hepatocytes. Immunological rejection of the embedded hepatocytes by the host immune system is a serious concern that crucially degrades the performance of the device. Induced pluripotent stem (iPS) cells are considered a desirable source for bioartificial liver systems, because patient-derived iPS cells are free from immunological rejection. The purpose of this paper was to test the feasibility of a bioartificial liver system with iPS cell-derived hepatocyte-like cells.
Methods: Mouse iPS cells were differentiated into hepatocyte-like cells by a multi-step differentiation protocol via embryoid bodies and definitive endoderm. Differentiation of iPS cells was evaluated by morphology, PCR assay, and functional assays. iPS cell-derived hepatocyte-like cells were cultured in a bioreactor module with a pore size of 0.2 mu m for 7 days. The amount of albumin secreted into the circulating medium was analyzed by ELISA. Additionally, after a 7-day culture in a bioreactor module, cells were observed by a scanning electron microscope.
Results: At the final stage of the differentiation program, iPS cells changed their morphology to a polygonal shape with two nucleoli and enriched cytoplasmic granules. Transmission electron microscope analysis revealed their polygonal shape, glycogen deposition in the cytoplasm, microvilli on their surfaces, and a duct-like arrangement. PCR analysis showed increased expression of albumin mRNA over the course of the differentiation program. Albumin and urea production was also observed. iPS-Heps culture in bioreactor modules showed the accumulation of albumin in the medium for up to 7 days. Scanning electron microscopy revealed the attachment of cell clusters to the hollow fibers of the module. These results indicated that iPS cells were differentiated into hepatocyte-like cells after culture for 7 days in a bioreactor module with a pore size of 0.2 mu m.
Conclusion: We consider the combination of a bioreactor module with a 0.2-mu m pore membrane and embedded hepatocytes differentiated from iPS cells to be a promising option for bioartificial liver systems. This paper provides the basic concept and preliminary data for an iPS cell-oriented bioartificial liver system. PACS code: 87. Biological and medical physics, 87.85.-d Biomedical engineering, 87.85.Lf Tissue engineering, 87.85.Tu Modeling biomedical systems.

DOI： 10.1186/1475-925X-11-93

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