研究者詳細 - 髙村　浩由

論文 - 髙村　浩由

分割表示 68 件中 1 - 20 件目／全件表示 >>

A direct oxidative esterification of aldehydes with alcohols mediated by photochemical C–H bromination 査読

Haru Ando, Sakura Kodaki, Hiroyoshi Takamura, Isao Kadota, Kenta Tanaka

Organic & Biomolecular Chemistry 22 ( 46 ) 9032 - 9035 2024年9月

Synthesis of Ozonides Mediated by Molecular Sieve Under Solvent-Free Conditions 査読

Mohamed R. El-kholany, Nana Kishimoto, Kenta Tanaka, Hiroyoshi Takamura, Isao Kadota

Tetrahedron 134137 - 134137 2024年7月

Total synthesis and structure–antifouling activity relationship of scabrolide F 査読

Hiroyoshi Takamura, Yuki Sugitani, Ryohei Morishita, Takefumi Yorisue, Isao Kadota

Organic & Biomolecular Chemistry 22 ( 28 ) 5739 - 5747 2024年5月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Royal Society of Chemistry (RSC)

The details of our total synthesis of scabrolide F are described. The synthetic scabrolide F and its synthetic intermediates exhibited antifouling activity without toxicity.

DOI： 10.1039/d4ob00698d

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Strongly reducing helical phenothiazines as recyclable organophotoredox catalysts 査読

Haru Ando, Hiroyoshi Takamura, Isao Kadota, Kenta Tanaka

Chemical Communications 60 ( 36 ) 4765 - 4768 2024年3月

Efficient Method for the Preparation of Ozonides Under Dry Conditions 査読国際共著国際誌

Mohamed R. El-kholany, Nana Kishimoto, Kenta Tanaka, Hiroyoshi Takamura, Isao Kadota

Bulletin of the Chemical Society of Japan 96 ( 12 ) 1316 - 1318 2023年10月

Relative stereochemical determination of the C61–C83 fragment of symbiodinolide using a stereodivergent synthetic approach 査読国際誌

Hiroyoshi Takamura, Kosuke Hattori, Takumi Ohashi, Taichi Otsu, Isao Kadota

Organic & Biomolecular Chemistry 21 ( 44 ) 8837 - 8848 2023年9月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Royal Society of Chemistry (RSC)

Stereodivergent synthesis of the C61–C74 and C69–C83 fragments of symbiodinolide elucidated the relative configuration of its C61–C83 fragment.

DOI： 10.1039/d3ob01420g

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Chemical synthesis and antifouling activity of monoterpene–furan hybrid molecules 査読国際誌

Hiroyoshi Takamura, Yuya Kinoshita, Takefumi Yorisue, Isao Kadota

Organic & Biomolecular Chemistry 21 ( 3 ) 632 - 638 2023年

Total Synthesis of Scabrolide F 査読国際誌

Hiroyoshi Takamura, Yuki Sugitani, Ryohei Morishita, Isao Kadota

Organic Letters 24 ( 42 ) 7845 - 7849 2022年10月

Chemical Synthesis and Biological Effect on Xylem Formation of Xylemin and Its Analogues 査読

Hiroyoshi Takamura, Hiroyasu Motose, Taichi Otsu, Shiori Shinohara, Ryugo Kouno, Isao Kadota, Taku Takahashi

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2020 ( 18 ) 2745 - 2753 2020年5月

担当区分：筆頭著者,　責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-V C H VERLAG GMBH

Xylemin (6) and its designed structural analogues 18-23, N-(4-aminobutyl)alkylamines, were synthesized by 2-nitrobenzenesulfonamide (Ns) strategy. Investigation of the improved synthesis of 20-23 resulted in the development of one-step synthesis of these analogues from the commercially available corresponding ketones. Biological assessment of the synthetic molecules elucidated that xylemin (6) and the analogue N-(4-aminobutyl)cyclopentylamine (21) promoted the expression level of thermospermine synthase ACAULIS5 (ACL5) and enhanced xylem formation. In addition, xylemin (6) was found to significantly promote lateral root formation, whereas xylemin analogues 18-23 including 21 did not. These results indicate that the analogue 21 has the potential as a novel inhibitor of thermospermine synthesis to work specifically in xylem differentiation.

DOI： 10.1002/ejoc.202000322

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Unified Total Synthesis, Stereostructural Elucidation, and Biological Evaluation of Sarcophytonolides 査読

Hiroyoshi Takamura, Isao Kadota

Journal of Synthetic Organic Chemistry, Japan 77 ( 12 ) 1190 - 1200 2019年12月

Stereocontrolled synthesis of the macrolactone core of neopeltolide 査読

Andreas Meissner, Nobuhiro Tanaka, Hiroyoshi Takamura, Isao Kadota

Tetrahedron Letters 60 ( 5 ) 432 - 434 2019年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier BV

A stereoselective synthesis of the macrolactone core of neopeltolide is described. The tetrahydropyran moiety was constructed via the intramolecular allylation of an alpha-acetoxy ether. A late-stage macrolactonization provided a known synthetic intermediate of neopeltolide. (C) 2018 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tetlet.2018.12.066

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Concise Synthesis of Anticancer Active trans-4-(4-Octylphenyl)prolinol 査読

Hiroyoshi Takamura, Minoru Tanaka, Junki Ando, Aoi Tazawa, Kohei Ishizawa

HETEROCYCLES 99 ( 1 ) 716 - 716 2019年

Stereodivergent and Stereoselective Synthesis of cis- and trans-4-Substituted Prolinols 査読

Hiroyoshi Takamura, Minoru Tanaka, Junki Ando, Aoi Tazawa, Kohei Ishizawa

HETEROCYCLES 99 ( 1 ) 188 - 188 2019年

Formal total synthesis of enigmazole A 査読

Andreas Meissner, Takayuki Kishi, Yuka Fujisawa, Yuto Murai, Hiroyoshi Takamura, Isao Kadota

Tetrahedron Letters 59 ( 51 ) 4492 - 4495 2018年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier BV

A stereoselective formal total synthesis of enigmazole A, a marine macrolide isolated from Cinachyrella enigmatica, is described. Lewis acid mediated intramolecular allylation of an alpha-acetoxy ether, prepared from alcohol and carboxylic acid fragments was carried out to construct the methylene THP ring with high stereoselectivity. The late-stage macrolactonization of the corresponding seco-acid provided a known synthetic intermediate of enigmazole A. (C) 2018 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tetlet.2018.11.017

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Unified Total Synthesis, Stereostructural Elucidation, and Biological Evaluation of Sarcophytonolides 査読

Hiroyoshi Takamura, Takahiro Kikuchi, Kohei Iwamoto, Eiji Nakao, Naoki Harada, Taichi Otsu, Noriyuki Endo, Yuji Fukuda, Osamu Ohno, Kiyotake Suenaga, Yue-Wei Guo, Isao Kadota

Journal of Organic Chemistry 83 ( 18 ) 11028 - 11056 2018年9月

Improved Synthesis of the A–E Ring Segment of Ciguatoxin CTX3C by Using Intramolecular Allylations 査読

Tokihiro Tanaka, Hiroki Asakura, Rie Fujiwara, Kentaro Kumamoto, Hiroaki Izuka, Kengo Shiroma, Hiroyoshi Takamura, Isao Kadota

Bulletin of the Chemical Society of Japan 91 ( 4 ) 507 - 514 2018年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：The Chemical Society of Japan

An improved synthesis of the A-E ring segment of ciguatoxin CTX3C is described. The E ring segment was synthesized by the intramolecular reaction of allylic stannane and aldehyde with high stereoselectivity. Construction of the A-E ring framework was performed by using the intramolecular allylation of alpha-acetoxy ether followed by ring-closing metathesis.

DOI： 10.1246/bcsj.20170390

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Recent topics of the stereodivergent synthesis of natural products 査読

Hiroyoshi Takamura

Tetrahedron Letters 59 ( 11 ) 955 - 966 2018年3月

Convergent total synthesis of (−)-dactylolide 査読

Tokihiro Tanaka, Yuto Murai, Takayuki Kishi, Hiroyoshi Takamura, Isao Kadota

Tetrahedron Letters 59 ( 8 ) 763 - 766 2018年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier BV

A convergent total synthesis of (-)-dactylolide is described. Constructing the 2,6-disubstituted exo-methylene THP moiety was achieved by the intramolecular allylation of alpha-acetoxy ether. The cyclization precursor was prepared from two segments, an alcohol and carboxylic acid derivatives, by esterification followed by reductive acetylation. (C) 2018 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.tetlet.2018.01.034

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Total Synthesis of Rhoiptelol B 査読

Isao Kadota, Nobuhiro Tanaka, Hiroyoshi Takamura

HETEROCYCLES 97 ( 2 ) 1157 - 1157 2018年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：The Japan Institute of Heterocyclic Chemistry

A stereoselective total synthesis of rhoiptelol B, a diarylheptanoid isolated from the fruits of Rhoiptelea chiliantha, is described. The tetrahydropyran ring was constructed via an intramolecular allylation methodology.

DOI： 10.3987/com-18-s(t)57

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Total Synthesis of Two Possible Diastereomers of Natural 6-Chlorotetrahydrofuran Acetogenin and Its Stereostructural Elucidation

Hiroyoshi Takamura, Tomoya Katsube, Kazuki Okamoto, Isao Kadota

CHEMISTRY-A EUROPEAN JOURNAL 23 ( 68 ) 17191 - 17194 2017年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-V C H VERLAG GMBH

The first total synthesis of two possible diastereomers of natural 6-chlorotetrahydrofuran acetogenin 1 has been achieved. The synthetic route features 5-exo-tet cyclization, Z selective Wittig reaction and Julia olefination for the construction of conjugated diene and enyne moieties, and stereoselective chlorination. Comparison of their H-1 and (CNMR)-C-13 data and specific rotation with those of the natural product elucidated the absolute configuration of natural (-)-6-chlorotetrahydrofuran acetogenin 1.

DOI： 10.1002/chem.201704514

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