2023/12/09 更新

写真a

コウノ ヨシヤス
河野 吉泰
KOUNO Yoshiyasu
所属
医歯薬学域 助教(特任)
職名
助教(特任)
外部リンク

学位

  • 博士(医学) ( 岡山大学 )

研究キーワード

  • 消化管出血

  • 化学療法

  • 抗血栓薬

  • 若年性消化器癌

  • 臨床腫瘍学

  • がんゲノム医療

  • irAE

  • 消化器内視鏡

 

論文

  • Usefulness of Acetic Acid Spray with Narrow-Band Imaging for Identifying the Margin of Sessile Serrated Lesions 国際誌

    Yoshiyasu Kono, Reiji Higashi, Hidetaka Mizushima, Daisuke Shimizu, Tetsuya Katayama, Masanari Kosaka, Issei Hirata, Tetsu Hirata, Tatsuhiro Gotoda, Koji Miyahara, Yuki Moritou, Masaki Kunihiro, Masahiro Nakagawa, Koichi Ichimura, Hiroyuki Okada

    DIGESTIVE DISEASES AND SCIENCES   68 ( 6 )   2553 - 2560   2023年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Background Sessile serrated lesions (SSLs) are precursors of colon cancer, especially in cases of large, right colon. However, they are difficult to not only detect, but only clarify the margin of the lesion, which can lead to the poor endoscopic treatment outcomes.Aims This study evaluated the usefulness of acetic acid spray with narrow-band imaging (A-NBI) for the better visualization of the margin of SSLs.Methods From January 2013 to March 2022, patients with superficial elevated polyps suspected of being SSLs >= 10 mm with an endoscopic diagnosis that had been endoscopically resected at Hiroshima City Hiroshima Citizens Hospital were enrolled. Endoscopic images with white-light imaging (WLI), narrow-band imaging (NBI), indigo-carmine (IC), and A-NBI were recorded in each lesion and were randomly arranged and assessed by 10 endoscopists. We compared the visibility score (1 to 4) and color differences (delta E) between inside and outside of the lesions among WLI, NBI, IC, and A-NBI.Results Forty-one lesions in 33 cases were included, and a total of 164 images were evaluated. As for the visibility score, most of the lesions were scored as 1 or 2 on WLI, whereas most were scored 4 on A-NBI. The median delta E of A-NBI was also significantly higher than that of WLI, NBI, or IC (20.5 vs. 8.3 vs. 8.2 vs. 12.3, P < 0.01). A significant correlation was observed between the color difference and visibility score (r = 0.53, P < 0.01).Conclusions A-NBI may be a useful modality for identifying the margin of SSLs.

    DOI: 10.1007/s10620-022-07816-x

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  • Endocrinological Changes after Anamorelin Administration in Patients with Gastrointestinal Cancer

    Sakiko Kuraoka, Masaya Iwamuro, Takuya Satomi, Tatsuhiro Yamazaki, Kenta Hamada, Yoshiyasu Kono, Hiromitsu Kanzaki, Hironari Kato, Fumio Otsuka, Hiroyuki Okada

    ACTA MEDICA OKAYAMA   77 ( 3 )   235 - 241   2023年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    Changes in hormone levels in patients with cancer cachexia after anamorelin administration have not been fully investigated. This study aimed to determine how anamorelin affects the endocrine system in patients with gastrointestinal cancer and cachexia. We prospectively enrolled 13 patients and comprehensively investigated their body weight and levels of serum albumin, hemoglobin A1c (HbA1c), and hormones before (week 0) and 3 and 12 weeks after anamorelin administration. The variables were evaluated at week 3 in 9 patients and at week 12 in 5 patients. At week 3, anamorelin administration resulted in body weight gain and increased the levels of growth hormone and HbA1c, as well as insulin-like growth factor-1 standard deviation scores (IGF-1 SD scores). At the same time, negative correlations were observed between ? IGF-1 SD score and ? thyroid-stimulating hormone (TSH) and between ? IGF-1 SD score and ? free testosterone. ? Body weight and ? IGF-1 SD score correlated positively at week 12. These results suggest that TSH and free testosterone levels can be affected 3 weeks after anamorelin administration; however, those variables tend to return to a state of equilibrium, and anabolic effects of anamorelin appear in long-term (= 12 weeks) users.

    DOI: 10.18926/AMO/65488

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  • 免疫関連有害事象(irAE:immune-related adverse events)による胃炎の5例

    岩室 雅也, 田中 健大, 平田 翔一郎, 河野 吉泰, 川野 誠司, 河原 祥朗, 大塚 基之

    日本消化器病学会中国支部例会プログラム・抄録集   119回   70 - 70   2023年6月

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    記述言語:日本語   出版者・発行元:日本消化器病学会-中国支部  

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  • 内反性増殖を示した十二指腸腺癌に対してUnderwater EMRにて切除し得た1例

    松枝 克典, 川野 誠司, 平田 翔一郎, 岡上 昇太郎, 里見 拓也, 稲生 祥子, 濱田 健太, 河野 吉泰, 岩室 雅也, 河原 祥朗, 田中 健大, 大塚 基之

    日本消化器内視鏡学会中国支部例会   130回   76 - 76   2023年6月

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    記述言語:日本語   出版者・発行元:日本消化器内視鏡学会-中国支部  

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  • Degree of pharyngeal deformation caused by pharyngeal endoscopic submucosal dissection is associated with the incidence of aspiration pneumonia. 国際誌

    Makoto Abe, Yoshiro Kawahara, Yuka Obayashi, Yuki Baba, Kenta Hamada, Hiroyuki Sakae, Yoshiyasu Kono, Hiromitu Kanzaki, Masaya Iwamuro, Seiji Kawano, Takuma Makino, Yohei Noda, Hidenori Marunaka, Hiroyuki Okada

    Endoscopy international open   11 ( 4 )   E351-E357   2023年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background and study aims  Endoscopic submucosal dissection (ESD) is one of the most minimally invasive treatments for superficial squamous cell cancer of the pharynx. However, aspiration pneumonia (AsP) associated with postoperative deformity of the pharynx may occur. The purpose of this study was to investigate the frequency of AsP and the degree of pharyngeal deformity after pharyngeal ESD. Patients and methods  This was a retrospective observational study of patients who underwent pharyngeal ESD at Okayama University Hospital between 2006 and 2017. The degree of pharyngeal deformation was assessed using the pharyngeal deformation grade (PDG). The primary endpoint was the frequency of AsP as a long-term adverse event. Results  Among the 52 patients enrolled, nine developed aspiration pneumonia, with a 3-year cumulative incidence of 9.0 % (95 % confidence interval [CI], 3.3 %-22.0 %). There were 16, 18, 16, and two patients that had PDG 0, 1, 2, and 3, respectively. Patients with a history of radiotherapy, as a treatment of head and neck cancer (44.4 % vs. 11.6 %; P  = 0.02) and the high PDG group (PDG 2 and 3) (77.8 % vs. 25.6 %; P  = 0.005) had a significantly higher incidence of AsP. The 3-year cumulative incidence rate of AsP after ESD in the high PDG group was significantly higher than that in the low PDG group (PDG 0 and 1) (23.9 % [95 %CI, 9.2.-49.5%] vs. 0 %; P  = 0.03). Conclusions  The incidence of aspiration pneumonia in the long-term course after pharyngeal ESD was revealed. The incidence of aspiration pneumonia may be associated with pharyngeal deformity, but further studies are needed.

    DOI: 10.1055/a-2033-9707

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  • Scattered Tiny Whitish Protrusions in the Stomach Are a Clue to the Diagnosis of Autoimmune Gastritis.

    Masaya Iwamuro, Takehiro Tanaka, Kenta Hamada, Yoshiyasu Kono, Hiromitsu Kanzaki, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada

    Acta medica Okayama   77 ( 1 )   75 - 80   2023年2月

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    記述言語:英語  

    Herein, we report two patients with autoimmune gastritis who had undergone multiple esophagogastroduodenoscopy procedures for 17 and 9 years, respectively, before their diagnosis. Instead, they had been diagnosed with and treated for Helicobacter pylori-associated gastritis. The correct diagnosis was made when scatterings of tiny whitish protrusions in the gastric mucosa were detected on esophagogastroduodenoscopy. Our findings suggest that scattered tiny whitish bumps may be a clue to the diagnosis of autoimmune gastritis.

    DOI: 10.18926/AMO/64365

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  • Differences in color between early gastric cancer and cancer-suspected non-cancerous mucosa on linked color imaging. 国際誌

    Hiromitsu Kanzaki, Yoshiro Kawahara, Takuya Satomi, Shotaro Okanoue, Kenta Hamada, Yoshiyasu Kono, Masaya Iwamuro, Seiji Kawano, Hiroyuki Okada

    Endoscopy international open   11 ( 1 )   E90-E96   2023年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background and study aims  Linked color imaging (LCI) can enhance the original color of each area and may useful to detect tumorous lesions during esophagogastroduodenoscopy. However, LCI may also enhance cancer-suspected non-cancerous regional color change. We conducted a retrospective image analysis to investigate the color characteristics of early gastric cancer (EGC) and cancer-suspected non-cancerous mucosa (CSM) in LCI. Methods  LCI images of both EGC and CSM were retrospectively collected from the database of the institution. Fifteen endoscopists individually judged each image as EGC or CSM. The color difference between the inside and outside of the lesions was measured by CIE-Lab analysis in both groups and compared. Results  A total of 245 LCI images of EGC (169) and CSM (76) were extracted and randomly lined for image collection. The test by the endoscopists showed accuracy, sensitivity, and specificity of 64.0 %, 63.7 %, and 64.0 %, respectively. Although the color difference between EGC and CSM was almost the same (12.5 vs. 12.9, not significant), each parameter of ΔL (bright: -0.3 vs. -2.7, P  < 0.001), Δa (Reddish: 7.2 vs. 9.6, P  = 0.004), and Δb (Yellowish: 6.4 vs. 3.8, P  < 0.001) was significantly different in the groups. The color feature of both positive ΔL and Δb to EGC showed accuracy, sensitivity, and specificity of 54.7 %, 39.6 %, 88.2%, respectively. Conclusions  The total color difference was almost the same between EGC and CSM; however, their color tones were different on linked color imaging. Although the color characteristics of EGC had high specificity, they also had low sensitivity.

    DOI: 10.1055/a-1989-6643

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  • Erratum: Differences in color between early gastric cancer and cancer-suspected non-cancerous mucosa on linked color imaging. 国際誌

    Hiromitsu Kanzaki, Yoshiro Kawahara, Takuya Satomi, Shotaro Okanoue, Kenta Hamada, Yoshiyasu Kono, Masaya Iwamuro, Seiji Kawano, Hiroyuki Okada

    Endoscopy international open   11 ( 1 )   C1   2023年1月

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    記述言語:英語  

    [This corrects the article DOI: 10.1055/a-1989-6643.].

    DOI: 10.1055/a-2018-7914

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  • Multiple White Plaques in the Esophagus: A Possible Case of Esophageal Mucosal Alteration Associated With Immune-Related Adverse Events of Immune Checkpoint Inhibitors. 国際誌

    Masaya Iwamuro, Takehiro Tanaka, Yoshiyasu Kono, Seiji Kawano, Horoyuki Okada

    Cureus   14 ( 12 )   e32710   2022年12月

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    記述言語:英語  

    We report two cases of multiple white plaques in the esophagus that emerged after the administration of immune checkpoint inhibitors. Both patients developed enterocolitis as immune-related adverse events associated with immune checkpoint inhibitors. Esophagogastroduodenoscopy revealed duodenal involvement and multiple white plaques in the esophagus. A biopsy of the esophagus showed predominant CD3+ lymphocyte infiltration, suggesting that esophageal mucosal alterations were associated with immune-related adverse events. In addition, histopathology showed keratinized stratified squamous epithelium in the first case while increased inflammatory cell infiltration in the intraepithelial and subepithelial layers was observed in the second case. These data suggest a different pathogenesis of the multiple esophageal white plaques between the two cases. Although further investigation is needed to elucidate the significance of these observations, recognition of the esophageal plaques may be important for prompt diagnosis of immune-related adverse events when associated with immune checkpoint inhibitors.

    DOI: 10.7759/cureus.32710

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  • Endoscopic findings of gastric neoplasms in familial adenomatous polyposis are associated with the phenotypic variations and grades of dysplasia. 国際誌

    Mayu Kobashi, Masaya Iwamuro, Sakiko Kuraoka, Shoko Inoo, Shotaro Okanoue, Takuya Satomi, Kenta Hamada, Makoto Abe, Yoshiyasu Kono, Hiromitsu Kanzaki, Seiji Kawano, Takehiro Tanaka, Yoshiro Kawahara, Hiroyuki Okada

    Medicine   101 ( 41 )   e30997   2022年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Patients with familial adenomatous polyposis (FAP) are at increased risk of developing gastric neoplasms. However, endoscopic findings have not been sufficiently investigated. We investigated the phenotypic expression of gastric adenoma (low-grade dysplasia) and gastric cancer (high-grade dysplasia or carcinoma) in patients with FAP and clarified their relationships to endoscopic findings. Of 29 patients with FAP who underwent esophagogastroduodenoscopy between 2005 and 2020, 11 (38%) had histologically confirmed gastric neoplasms, including 23 lesions of gastric adenoma and 9 lesions of gastric cancer. The gastric neoplasms were classified into 3 phenotypes (gastric, mixed, or intestinal type) according to the immunostaining results and evaluated for location (U or M region: upper or middle third of the stomach or L region: lower third of the stomach), color (same as the background mucosa, whitish, or reddish), macroscopic type (elevated, flat, or depressed), background mucosal atrophy (present or absent), fundic gland polyps in the surrounding mucosa (present or absent), and morphologic changes in tumor size. Elevated whitish gastric adenomas were further subdivided by macroscopic type (flat elevated, protruded, or elevated with a central depression) and color (milky- or pinkish-white). The gastric adenomas included gastric (11/23, 48%), mixed (4/23, 17%), and intestinal (8/23, 35%) phenotypes. In contrast, no lesions of gastric cancers showed a gastric phenotype (0/9, 0%), while 5 (56%) and 4 (44%) lesions were intestinal and mixed phenotypes, respectively. Gastric cancers were significantly more likely than gastric adenomas to present as reddish depressed lesions with gastric atrophy. All gastric-type adenomas occurred in non-atrophic mucosa, in mucosa with fundic gland polyps in the periphery, in the U or M region, and as flat elevated or protruded lesions with a milky-white color. Half of the lesions increased in size. Meanwhile, the typical endoscopic features of intestinal-type adenomas included occurrence in the L region and elevated pinkish-white lesions with central depression. None of the intestinal-type adenomas increased in size during the observation period. We believe that these endoscopic features will be useful for the prompt diagnosis and appropriate management of gastric neoplasms in patients with FAP.

    DOI: 10.1097/MD.0000000000030997

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  • Postoperative Bleeding Risk after Gastric Endoscopic Submucosal Dissection in Patients Receiving a P2Y12 Receptor Antagonist. 国際誌

    Ryosuke Hirai, Seiji Kawano, Shoko Inoo, Sakiko Kuraoka, Shotaro Okanoue, Takuya Satomi, Kenta Hamada, Yoshiyasu Kono, Hiromitsu Kanzaki, Masaya Iwamuro, Yoshiro Kawahara, Hiroyuki Okada

    Gut and liver   17 ( 3 )   404 - 411   2022年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND/AIMS: The safety of gastric endoscopic submucosal dissection (ESD) in users of a P2Y12 receptor antagonist (P2Y12RA) under current guidelines has not been verified. METHODS: Patients treated by gastric ESD at Okayama University Hospital between January 2013 and December 2020 were registered. The postoperative bleeding rates of patients (group A) who did not receive any antithrombotic drugs; patients (group B) receiving aspirin or cilostazol monotherapy; and P2Y12RA users (group C) those on including monotherapy or dual antiplatelet therapy were compared. The risk factors for post-ESD bleeding were examined in a multivariate analysis of patient background, tumor factors, and antithrombotic drug management. RESULTS: Ultimately, 1,036 lesions (847 patients) were enrolled. The bleeding rates of group B and C were significantly higher than that of group A (p=0.012 and p<0.001, respectively), but there was no significant difference between group B and C (p=0.11). The postoperative bleeding rate was significantly higher in dual antiplatelet therapy than in P2Y12RA monotherapy (p=0.014). In multivariate analysis, tumor diameter ≥12 mm (odds ratio [OR], 4.30; 95% confidence interval [CI], 1.99 to 9.31), anticoagulant use (OR, 4.03; 95% CI, 1.64 to 9.86), and P2Y12RA use (OR, 3.40; 95% CI, 1.07 to 10.70) were significant risk factors for postoperative bleeding. CONCLUSIONS: P2Y12RA use is a risk factor for postoperative bleeding in patients who undergo ESD even if receiving drug management according to guidelines. Dual antiplatelet therapy carries a higher risk of bleeding than monotherapy.

    DOI: 10.5009/gnl220196

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  • Prognosis after curative resection for stage IA gastric cancer in elderly patients: endoscopic submucosal dissection versus surgery

    Koji Miyahara, Michihiro Ishida, Yoshiyasu Kono, Tetsu Hirata, Yuka Obayashi, Tatsuhiro Gotoda, Yuki Ninomiya, Yuki Moritou, Masaki Kunihiro, Tetsushi Kubota, Yasuhiro Choda, Yasuhiro Shirakawa, Masahiro Nakagawa, Hiroyuki Okada

    SURGERY TODAY   52 ( 9 )   1329 - 1340   2022年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    Purpose To establish whether gastrectomy for early gastric cancer (EGC) in elderly patients is related to poor survival. Methods The subjects of this retrospective study were patients aged >= 75 years with primary stage IA EGC, who underwent curative resection with endoscopic submucosal dissection (ESD) or surgery. Results We analyzed data on 365 patients who underwent ESD and 170 patients who underwent surgery. Overall survival (OS) was not significantly different for the ESD group vs. the surgery group (5-year cumulative rates, 81.5% vs. 79.7%; log-rank test, P = 0.506). Multivariate analysis revealed that treatments; namely, ESD or surgery, were not associated with OS (hazard ratio 1.09, 95% confidence interval 0.77-1.51). Similar results were observed even in the subgroups with worse conditions, such as age > 80 years, Eastern Cooperative Oncology Group performance status 2-3, Charlson comorbidity index >= 2, and prognostic nutritional index <= 46.7. Using propensity score matching, we selected 88 pairs of patients who underwent ESD or surgery with baseline characteristics matched and found that OS was not different between the two groups (log-rank test, P = 0.829). Conclusion OS was comparable for elderly patients who underwent ESD and those who underwent surgery for EGC. Surgical invasiveness did not worsen the prognosis, even for elderly patients.

    DOI: 10.1007/s00595-022-02456-0

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  • Site-specific differences in T lymphocyte composition of the gastric mucosa after Helicobacter pylori eradication. 国際誌

    Masaya Iwamuro, Takahide Takahashi, Natsuki Watanabe, Makoto Abe, Hiroyuki Sakae, Yoshiyasu Kono, Hiromitsu Kanzaki, Takehiro Tanaka, Seiji Kawano, Fumio Otsuka, Yoshiro Kawahara, Hiroyuki Yanai, Hiroyuki Okada

    Medicine   101 ( 34 )   e30241   2022年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    In our earlier work, we revealed that inflammation of the lesser curvature of the gastric body and antrum could constitute independent risk factors for gastric cancer development, while inflammation of the greater curvature was not. The aims of this study were as follows: first, to reveal the differences between T lymphocyte populations of the gastric antrum and the greater and lesser curvatures of the gastric body in patients after Helicobacter pylori eradication; second, to analyze the correlation between the composition of the stomach-resident T lymphocytes and time from H. pylori eradication; and third, to evaluate the sex differences in T lymphocyte subsets after H. pylori eradication. To investigate site-specific differences in stomach-resident T lymphocytes after H. pylori eradication, we performed flow cytometry analysis on samples taken from the gastric antrum, greater curvature of the gastric body, and lesser curvature of the gastric body of 20 patients. We also analyzed the correlation between the composition of the stomach-resident T lymphocytes and the time from H. pylori eradication. The lymphocyte subsets of the antrum and lesser curvature of the body were similar. In contrast, compared to those in the greater curvature of the gastric body, CD4+/CD3+ lymphocyte subsets (43.8 ± 19.4% vs 31.7 ± 14.6%) were elevated in the lesser curvature of the body, whereas CD8+/CD3+ (67.1 ± 21.3% vs 80.4 ± 12.0%), CD7+/CD3+ (91.2 ± 4.6% vs 93.7 ± 3.8%), CCR4+/CD3+ (7.7 ± 8.1% vs 10.4 ± 7.0%), CD45RA+/CD3+CD4+ (27.2 ± 24.8% vs 39.5 ± 20.8%), and CD45RA+/CD3+CD4- (14.2 ± 11.1% vs 18.7 ± 11.5) were lower. Linear regression analysis showed a negative correlation between the time after H. pylori eradication and CD4+/CD3+ (P < .05, R2 = 0.198). There were no significant differences between men and women with respect to the lymphocyte populations. These results indicate that there are site-specific differences in lymphocyte composition in the stomach after H. pylori eradication.

    DOI: 10.1097/MD.0000000000030241

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  • Characterization of Gastric Tissue-Resident T Cells in Autoimmune and Helicobacter pylori-Associated Gastritis. 国際誌

    Daisuke Kametaka, Masaya Iwamuro, Takahide Takahashi, Araki Hirabata, Kenta Hamada, Yoshiyasu Kono, Hiromitsu Kanzaki, Seiji Kawano, Takehiro Tanaka, Fumio Otsuka, Yoshiro Kawahara, Hiroyuki Okada

    Current issues in molecular biology   44 ( 6 )   2443 - 2452   2022年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Data regarding the in-depth surface marker profiles of gastric tissue-resident lymphocytes in autoimmune and Helicobacter pylori-associated gastritis are lacking. In this study, we investigated potential differences in lymphocyte composition between these profiles. We enrolled patients with autoimmune (n = 14), active (current infection of H. pylori in the stomach; n = 10), and inactive gastritis (post-eradication of H. pylori; n = 20). Lymphocytes were isolated from the greater curvature of the stomach and lesser curvature of the body and analyzed using flow cytometry. The CD8+/CD3+ and CD4+/CD3+ ratios differed between the samples. Body CD4+/antrum CD4+, which is calculated by dividing the CD4+/CD3+ ratio in the body by that in the antrum, was significantly higher in autoimmune gastritis (3.54 ± 3.13) than in active (1.47 ± 0.41) and inactive gastritis (1.42 ± 0.77). Antrum CD8+/CD4+ in autoimmune gastritis (7.86 ± 7.23) was also higher than that in active (1.49 ± 0.58) and inactive gastritis (2.84 ± 2.17). The area under the receiver operating characteristic curve of antrum CD8+/CD4+ was 0.842, and the corresponding optimal cutoff point was 4.0, with a sensitivity of 71.4% and a specificity of 93.3%. We propose that an antrum CD8+/CD4+ ratio &gt; 4.0 is a potential diagnostic marker for autoimmune gastritis.

    DOI: 10.3390/cimb44060167

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  • 胃癌と非癌粘膜の白色球状外観(white globe appearance)の差異に関する検討

    岩室 雅也, 田中 健大, 榮 浩行, 安部 真, 河野 吉泰, 神崎 洋光, 川野 誠司, 河原 祥朗, 岡田 裕之

    Gastroenterological Endoscopy   64 ( 1 )   29 - 36   2022年1月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

    【背景・目的】胃癌と非癌粘膜の白色球状外観(white globe appearance:WGA)の違いを明らかにする.【方法】胃WGA症例の内視鏡所見と臨床的特徴を後ろ向きに解析した.【結果】胃癌18例,非癌23例にWGAを認めた.胃癌症例は7例(38.9%),非癌症例は17例(73.9%)がプロトンポンプ阻害剤(proton pump inhibitor:PPI)を内服していた.病理学的には,胃癌症例(18例)のうち腺管の嚢胞状拡張は12例(66.7%),腺腔内壊死物質は12例(66.7%),壁細胞の過形成と内腔への鋸歯状の突出(parietal cell protrusion:PCP)は1例(5.6%)でみられた.一方,非癌症例のうち14例で生検が実施され,腺管の嚢胞状拡張は8例(57.1%),PCPは7例(50.0%)でみられたが,腺腔内壊死物質は指摘できなかった.非癌群において,自己免疫性胃炎を2例,内視鏡的粘膜下層剥離術後瘢痕を2例,腺腫を1例,ランタン沈着を1例,胃MALTリンパ腫を1例に認めた.【結論】胃癌粘膜と非癌粘膜ではWGAの成因は異なり,非癌症例ではPPI服用が関与している可能性が示唆された.(著者抄録)

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    その他リンク: https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J00192&link_issn=&doc_id=20220125370003&doc_link_id=10.11280%2Fgee.64.29&url=https%3A%2F%2Fdoi.org%2F10.11280%2Fgee.64.29&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

  • Zinc Acetate Dihydrate Tablet-associated Gastric Lesions.

    Masaya Iwamuro, Takehiro Tanaka, Sakiko Kuraoka, Kenta Hamada, Makoto Abe, Yoshiyasu Kono, Hiromitsu Kanzaki, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada

    Internal medicine (Tokyo, Japan)   61 ( 13 )   1931 - 1938   2022年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Objective This study aimed to determine the prevalence and endoscopic features of zinc acetate dihydrate tablet-associated gastric lesions. Methods We retrospectively examined the endoscopic features of 47 patients taking zinc acetate dihydrate tablets who underwent esophagogastroduodenoscopy. Results Gastric mucosal alterations, including redness, erosions, ulcers, and adhesion of the white coat, were observed in 29 of 47 patients (61.7%). Among patients with gastric lesions (group A), there was a significantly higher percentage of symptomatic patients in comparison to patients without lesions (group B) (65.5% vs. 22.2%; p<0.01). The background characteristics of the two groups did not differ to a statistically significant extent. On esophagogastroduodenoscopy, mucosal redness (n=27, 93.1%), erosions (n=26, 90.0%), adhesion of the white coat (n=25, 86.2%), and ulcers (n=9, 31.0%) were observed. None of the 19 patients who previously underwent esophagogastroduodenoscopy had gastric lesions before starting zinc acetate dihydrate. Esophagogastroduodenoscopy was performed after the cessation of zinc acetate dihydrate intake in six patients, and revealed the resolution of gastric lesions. Conclusion Gastric lesions were observed in 29 of 47 patients who were taking zinc acetate dihydrate tablets. The most common endoscopic findings were mucosal redness (93.1%), erosions (90.0%), adhesion of the white coat (86.2%), and ulcers (31.0%). Although the exact pathogenesis is uncertain, we believe that understanding the unique manifestations of this gastric lesion will help physicians manage adverse events in patients taking zinc acetate dihydrate tablets.

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  • [Zinc acetate-associated gastric lesions:a case report].

    Masaya Iwamuro, Yoshiyasu Kono, Takehiro Tanaka, Kenta Hamada, Hiromitsu Kanzaki, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   119 ( 9 )   853 - 857   2022年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    An 82-year-old Japanese man underwent esophagogastroduodenoscopy for postprandial epigastric discomfort. The patient was diagnosed with hypozincemia with a serum zinc level of 63μg/dL (normal range:80-130μg/dL), and he had commenced oral intake of zinc acetate 1 month before the esophagogastroduodenoscopy. Endoscopy showed erosions with white-coated mucosa surface adhesions and erythema on the lesser curvature of the gastric body. Moderately differentiated tubular adenocarcinoma was suspected based on the biopsy examination findings;therefore, he was referred to our hospital for further examination and treatment. A repeat endoscopy showed two erosions with white-coated mucosa surface adhesion and erythema on the lesser curvature of the gastric body. However, the lesion location was different from that detected in the initial endoscopy. The biopsy showed no neoplastic changes. Therefore, based on the endoscopic findings and history of oral zinc acetate administration, we diagnosed the gastric mucosal injury as zinc acetate-associated gastric lesions. The cessation of zinc acetate intake resulted in the resolution of gastric lesions. Reassessment of the biopsy specimen from the initial endoscopy revealed erosions, epithelial cells showing infarct-like necrosis, degenerative atypical cells, and necrotic substances, which were misdiagnosed as neoplastic changes. This case highlights the importance of recognizing the typical endoscopic features of a zinc acetate-associated gastric lesion to enable its prompt diagnosis during esophagogastroduodenoscopy.

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  • Scoring systems for differentiating gastrointestinal stromal tumors and schwannomas from leiomyomas in the stomach. 国際誌

    Shotaro Okanoue, Masaya Iwamuro, Takehiro Tanaka, Takuya Satomi, Kenta Hamada, Hiroyuki Sakae, Makoto Abe, Yoshiyasu Kono, Hiromitsu Kanzaki, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada

    Medicine   100 ( 40 )   e27520   2021年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    ABSTRACT: There is no practical predictive model for the diagnosis of gastrointestinal stromal tumors (GISTs). To establish a practical predictive model for the diagnosis of subepithelial lesions in the stomach, we reviewed patients with GISTs (n = 89), schwannomas (n = 7), and leiomyomas (n = 28).The tumor was more frequently found along the gastric cardia in the leiomyoma group (57.1%) than in the GIST/schwannoma group (2.1%, P < .01). Contrast enhancement (57.3% vs 0%, P < .01) and intra-tumoral necrosis (34.4% vs 0.0%, P < .01) were more frequently observed in the GIST/schwannoma group than in the leiomyoma group. On endoscopic ultrasonography, 58.3% of GISTs/schwannomas showed uneven echogenicity, whereas the echogenicity was uneven in 21.4% of leiomyomas (P < .01). There were no differences between the tumor color and the presence or absence of ulcer formation, tumor bleeding, irregularity of the tumor margin, cystic spaces, and hyperechoic spots between the 2 groups. Based on these results, we developed a 2-step diagnostic algorithm for GISTs/schwannomas. The first step comprises 1 endoscopic feature: a cardiac or non-cardiac location. Tumors with a cardiac location were judged as leiomyomas and those with a non-cardiac location were judged as GISTs/schwannomas, with 96.9% sensitivity and 57.1% specificity for GIST/schwannoma diagnosis. The second step comprises a combination of endoscopic (non-cardiac location), radiologic (positive contrast enhancement and intra-tumoral necrosis), and endosonographic (uneven echogenicity) features for a total of 4 points. We assigned 1 point to each feature. Tumors with scores of 2 to 4 were judged as GISTs/schwannomas, with 81.3% sensitivity and 92.9% specificity for GIST/schwannoma diagnosis.Our predictive model will be a practical guide for the management of gastric subepithelial lesions.

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  • 家族性大腸腺腫症の胃病変の形質発現と内視鏡的特徴の検討

    小橋 真由, 岩室 雅也, 亀高 大介, 岡上 昇太郎, 里見 拓也, 濱田 健太, 榮 浩行, 安部 真, 河野 吉泰, 神崎 洋光, 川野 誠司, 河原 祥朗, 田中 健大, 岡田 裕之

    Gastroenterological Endoscopy   63 ( Suppl.2 )   2023 - 2023   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • A prospective multicenter study of the magnifying endoscopic evaluation of the invasion depth of superficial esophageal cancers. 国際誌

    Tatsuhiro Gotoda, Keisuke Hori, Masahiro Nakagawa, Sayo Kobayashi, Tatsuya Toyokawa, Shuhei Ishiyama, Atsushi Imagawa, Makoto Abe, Yoshiyasu Kono, Hiromitsu Kanzaki, Masaya Iwamuro, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada

    Surgical endoscopy   36 ( 5 )   3451 - 3459   2021年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Treatment strategies for superficial esophageal squamous cell carcinoma (SESCC) are determined mainly on the basis of the invasion depth. The Japan Esophageal Society (JES) developed a simplified magnifying endoscopic classification for estimating the invasion depth of SESCC. We aimed to evaluate its accuracy. METHODS: We prospectively applied the JES classification for estimating the invasion depth of SESCC to 204 consecutive lesions from 6 hospitals in Japan between April 2016 and October 2018. We analyzed the accuracy of the endoscopic diagnosis by adding the following two categories to the JES classification: ≥ 7 mm lesion in B2 vessels (defined as B2 ≥ 7 mm) and B2 vessels with inflammation (defined as B2i). RESULTS: After applying the exclusion criteria, 201 lesions remained in the analysis. The diagnostic value of type B1, B2, B3 vessels were as follows: sensitivity, 93.9%, 68.0%, 25.0%; specificity, 81.1%, 89.2%, 99.4%; positive predictive value (PPV), 95.6%, 47.2%, 75.0%; negative predictive value (NPV), 75.0%, 95.1%, 95.4%; and accuracy, 91.5%, 86.5%, 95.0%, respectively. A retrospective analysis showed that the diagnostic accuracy was higher in type B2 vessels (86.5% to 92.0%). An avascular area (AVA) was found in 55 (27%) of the 201 lesions, which tended to be associated with a deeper pathological diagnosis of each Type B vessel. In an additional analysis, B2 ≥ 7 mm and B2i improved the diagnostic accuracy of type B2 vessels from 86.5% to 92.0%. CONCLUSIONS: The JES classification is useful for estimating the invasion depth of SESCC. The diagnostic accuracy for type B2 vessels was low, which may be improved by using B2 ≥ 7 mm and B2i.

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  • Vonoprazan versus lansoprazole in the treatment of artificial gastric ulcers after endoscopic submucossal dissection: a randomized, open-label trial. 国際誌

    Daisuke Kawai, Ryuta Takenaka, Mikako Ishiguro, Shotaro Okanoue, Tatsuhiro Gotoda, Yoshiyasu Kono, Koji Takemoto, Hirofumi Tsugeno, Shigeatsu Fujiki

    BMC gastroenterology   21 ( 1 )   236 - 236   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: Vonoprazan is more potent and longer acting than traditional proton pump inhibitor. Although vonoprazan is expected to be superior to proton pump inhibitor, its efficacy in the treatment of gastric ulcers following endoscopic submucosal dissection (ESD) is not fully understood. The aim of this study was to evaluate the effectiveness of vonoprazan in artificial ulcer healing following ESD. METHODS: Patients with gastric tumors were randomly assigned to the vonoprazan group (group V) or lansoprazole group (group L) after ESD. Patients received intravenous lansoprazole (30 mg) twice on the day of ESD. Thereafter, patients were treated with vonoprazan (20 mg/day) in group V or lansoprazole (30 mg/day) in group L. Esophagogastroduodenoscopy was performed 4 and 8 weeks after the ESD. RESULTS: A total of 168 patients were analyzed. The 4-week healing rate for artificial ulcer was not significantly higher in group V versus group L (17/85, 20.0% vs. 14/83, 16.9%, respectively). In addition, there were no significant differences between the 4-week shrinkage rates between the two groups. Postoperative bleeding occurred in none of the patients in group V and three in group L. One patient in group V presented delayed perforation 2 days after ESD. CONCLUSIONS: Vonoprazan might not be superior to lansoprazole in the healing of artificial gastric ulcer after ESD. TRIAL REGISTRATION: University hospital Medical Information Network (registration number: UMIN000016642), Registered 27 February 2015, https://www.umin.ac.jp/ctr/index-j.htm.

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  • Linked Color Imaging (LCI) Emphasizes the Color Changes in the Gastric Mucosa After Helicobacter pylori Eradication. 国際誌

    Hiroyuki Sakae, Hiromitsu Kanzaki, Takuya Satomi, Shotaro Okanoue, Yuka Obayashi, Kenta Hamada, Makoto Abe, Yoshiyasu Kono, Ko Miura, Masaya Iwamuro, Seiji Kawano, Yoshiro Kawahara, Takehiro Tanaka, Hiroyuki Yanai, Hiroyuki Okada

    Digestive diseases and sciences   67 ( 6 )   2375 - 2384   2021年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    BACKGROUND: Diffuse redness is a characteristic endoscopic finding that indicates current infection of Helicobacter pylori, which is reduced after successful eradication. Linked color imaging (LCI) has been reported to improve the visibility of diffuse redness compared to white light imaging (WLI); however, quantitative evaluation has not been reported. AIMS: This study aimed to objectively evaluate the color change of the gastric mucosa after H. pylori eradication. METHODS: Images of the greater curvature of the antrum and corpus were captured, and the sites were biopsied during esophagogastroduodenoscopy (EGD) before and 1 year after eradication. The region of interest (ROI) was set around the biopsied area on the images. The color difference (ΔE) before and after eradication was calculated using the CIE L*a*b* color space. The association between the histological evaluation and the color value of the corresponding ROI was determined. RESULTS: At the antrum, there was no significant color change with either mode. At the corpus, the a* value, which reflected redness, decreased significantly after eradication with both modes (WLI: 41.2 to 36.0, LCI: 37.5 to 25.5); the b* value, reflecting yellowish, decreased with WLI, but increased significantly with LCI (WLI: 44.6 to 41.6, LCI: 23.9 to 29.2). The ΔE was significantly larger with LCI than with WLI (16.5 vs. 8.6). The a* values at the corpus were generally associated with histological neutrophil infiltration. CONCLUSIONS: Quantitative evaluation revealed that LCI emphasizes the change in color of the gastric mucosa due to the reduction in diffuse redness.

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  • Risk Factors for Gastric Cancer after the Eradication of Helicobacter pylori Evaluated Based on the Background Gastric Mucosa: A Propensity Score-matched Case-control Study.

    Yuka Obayashi, Seiji Kawano, Hiroyuki Sakae, Makoto Abe, Yoshiyasu Kono, Hiromitsu Kanzaki, Masaya Iwamuro, Yoshiro Kawahara, Takehiro Tanaka, Hiroyuki Yanai, Hiroyuki Okada

    Internal medicine (Tokyo, Japan)   60 ( 7 )   969 - 976   2021年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    Objective The eradication of Helicobacter pylori (H. pylori) reduces the risk for gastric cancer (GC) development, but it cannot prevent GC completely. We investigated the risk factors of early GC development after the eradication of H. pylori, based on the histological characteristics of gastric mucosa. Methods Sixty-one patients who underwent endoscopic submucosal dissection for early GC after successful H. pylori eradication (Group A) and 122 patients without developing a gastric neoplasm over 3 years after successful H. pylori eradication (Group B) were analyzed. We compared the histological findings of the patients enrolled in Group A and Group B before and after the propensity score-matching. Results Comparing the characteristics of two the groups, Group A consisted predominantly of males, had significantly more elderly patients, and the years after successful eradication tended to be longer. We performed score matching for these three factors to reduce the influence of any confounding factors. After matching, the scores of inflammation for Group A (n=54) was significantly higher than those of Group B (n=54) at the greater curvature of the antrum, the lesser curvature of the corpus, and the greater curvature of the corpus. According to a multivariate analysis, inflammation of the greater curvature of the antrum and lesser curvature of the corpus were found to be independent risk factors. The risk ratio and 95% CI were 5.92 (2.11-16.6) (p<0.01), and 3.56 (1.05-13.2) (p=0.04), respectively. Conclusion A continuous high level of inflammation of the background gastric mucosa may be a risk factor for gastric cancer onset after H. pylori eradication.

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  • Association Between Immune-Related Adverse Events and the Prognosis of Patients with Advanced Gastric Cancer Treated with Nivolumab. 国際誌

    Yoshiyasu Kono, Yasuhiro Choda, Masahiro Nakagawa, Koji Miyahara, Michihiro Ishida, Tetsushi Kubota, Keiji Seo, Tetsu Hirata, Yuka Obayashi, Tatsuhiro Gotoda, Yuki Moritou, Yoshiko Okikawa, Yasuo Iwamoto, Hiroyuki Okada

    Targeted oncology   16 ( 2 )   237 - 248   2021年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER  

    BACKGROUND: Little is known about the association between immune-related adverse events (irAEs) and the efficacy and survival outcomes of nivolumab in patients with advanced gastric cancer (AGC). OBJECTIVE: The present study examined the association between irAEs and the prognosis of patients with AGC treated with nivolumab. PATIENTS AND METHODS: From July 2017 to November 2020, patients who had been diagnosed with advanced unresected gastric cancer and treated with nivolumab at our institution were included in this analysis. We compared the clinical and survival outcomes between the irAE and non-irAE groups. We also evaluated the factors associated with better survival in patients treated with nivolumab. RESULTS: A total of 52 patients were included in the present study, and irAEs were observed in 13 (25%). Among the patients with measurable lesions (n = 29), the disease control rates were significantly higher in the irAE group than in the non-irAE group (88 vs. 24%; P = 0.0033). At the 8- and 12-week landmark analyses, the median overall survival (OS) in the irAE group was significantly longer than that in the non-irAE group, whereas the median progression-free survival was comparable between the groups. A multivariate analysis by Cox proportional hazard regression at the 8-week landmark revealed that the development of irAEs (hazard ratio 0.18; 95% confidence interval 0.0099-0.86) alone was positively associated with a longer OS. CONCLUSIONS: The development of irAEs might be associated with survival outcomes with nivolumab treatment in patients with AGC.

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  • [Clinical characteristics of five patients with gastric emphysema].

    Masaya Iwamuro, Makoto Abe, Yoshiyasu Kono, Hiromitsu Kanzaki, Keisuke Hori, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   118 ( 9 )   851 - 858   2021年

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    記述言語:日本語   掲載種別:研究論文(学術雑誌)  

    Gastric emphysema is a rare condition in which gas from a nonbacterial source accumulates within the gastric wall. In this study, we retrospectively analyzed the cases of five patients who were diagnosed with gastric emphysema at the Okayama University Hospital between January 2010 and April 2021, to reveal the clinical features of the disease. Based on their reviews, we revealed that:i) gastric emphysema occurred in hospitalized bedridden patients (n=5), such as those during/after endotracheal intubation (n=3), those undergoing gastric tube placement (n=3), those undergoing percutaneous endoscopic gastrostomy (n=1), and those undergoing treatment for cerebral infarction (n=1);ii) gastric emphysema was accompanied by the accumulation of gas in the portal (n=4) or gastric veins (n=1);iii) gastric emphysema was accompanied by colon wall thickness increase (n=4);iv) esophagogastroduodenoscopy showed redness, erosions, coarse mucosa, and/or ulcers (n=5);v) a clear boundary between the damaged area and the intact mucosa was observed (n=5);vi) the anterior wall of the stomach was less affected (n=4);vii) mucosal damage was predominant in the gastric folds, whereas the furrow of the mucosa was less affected;and viii) treatment with enteral nutrition suspension and the administration of proton pump inhibitors and antibiotics resulted in the recovery of patients from gastric emphysema (n=5). These results indicate that patients with gastric emphysema have distinct clinical, endoscopic, and radiological features. Furthermore, our results show that these patients can be conservatively managed.

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  • Reality of Gastric Cancer in Young Patients: The Importance and Difficulty of the Early Diagnosis, Prevention and Treatment.

    Yoshiyasu Kono, Hiromitsu Kanzaki, Masaya Iwamuro, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada

    Acta medica Okayama   74 ( 6 )   461 - 466   2020年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:OKAYAMA UNIV MED SCHOOL  

    Gastric cancer usually arises in middle-aged to older patients, and is rarely found in younger patients. The clin-ical characteristics, etiology, prognosis, preventive methods and treatment of gastric cancer in young patients have not been fully investigated because of its low prevalence. In this review, we discuss the current under-standing and clinical problems associated with gastric cancer in young patients. Helicobacter pylori (H. pylori), which is a major cause of gastric cancer, especially in older populations, is closely associated with gastric cancer in young patients as well as in older patients. Gastric cancer in young patients tends to be diagnosed at an advanced stage with alarm symptoms. However, young patients with advanced gastric cancer tend to have a favorable general condition and organ function, so they can tolerate intensive systematic chemotherapy. Unfortunately, the prognosis of gastric cancer in young patients with an advanced stage is not favorable. We should not take this rare disease lightly, given its poor prognosis if patients are diagnosed at an unresectable stage. The evaluation of the H. pylori infection status and performance of H. pylori eradication therapy to prevent gastric cancer in young patients as well as the development of more intensive chemotherapy regimens for unre-sectable gastric cancer in young patients are warranted.

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  • Current evidence and issues of endoscopic submucosal dissection for gastric neoplasms during antithrombotic therapy.

    Yoshiyasu Kono, Issei Hirata, Tetsuya Katayama, Hisahiro Uemura, Tetsu Hirata, Tatsuhiro Gotoda, Koji Miyahara, Yuki Moritou, Masahiro Nakagawa

    Clinical journal of gastroenterology   13 ( 5 )   650 - 659   2020年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:SPRINGER JAPAN KK  

    Endoscopic submucosal dissection (ESD) for gastric neoplasms is a useful treatment globally. However, postoperative bleeding after gastric ESD is a serious, and sometimes life-threatening complication in patients receiving antithrombotic drugs, because antithrombotic drugs are considered to increase the risk of postoperative bleeding after gastric ESD. In contrast, withdrawal of antithrombotic drugs during the perioperative period increases the risk of thrombotic complications. Guidelines for the management of antithrombotic drugs during the periendoscopic period have been published by different countries, and recent guidelines place greater emphasis on the risk of thromboembolism with the discontinuation of antithrombotic drugs than on the risk of bleeding with the continuation of antithrombotic drugs. Several studies have reported on the validity of these guidelines, and clinical evidence is being established. Most studies reported that gastric ESD under continuation of aspirin or cilostazol did not increase the risk of bleeding, whereas heparin replacement was strongly associated with a higher risk of bleeding. However, the data regarding some clinical issues about the management of antithrombotic drugs, such as the safety of gastric ESD under continuation of thienopyridine, administration of multiple antithrombotic drugs including dual antiplatelet and anticoagulants (warfarin and direct oral anticoagulant), and effective prophylactic methods for postoperative bleeding after gastric ESD are lacking. Larger clinical data are needed to resolve the remaining issues in the future.

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  • A case of esophagitis induced by apixaban. 国際誌

    Yoshiyasu Kono, Koji Miyahara, Masahiro Nakagawa

    Journal of gastrointestinal and liver diseases : JGLD   29 ( 3 )   471 - 471   2020年9月

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    記述言語:英語   出版者・発行元:MEDICAL UNIV PRESS  

    DOI: 10.15403/jgld-2685

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  • Acetic Acid Spray With Narrow-Band Imaging Is Useful to Clarify the Margin of Sessile Serrated Adenoma/Polyp. 国際誌

    Kana Onishi, Yoshiyasu Kono, Reiji Higashi

    The American journal of gastroenterology   115 ( 8 )   1160 - 1160   2020年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

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  • Clinical Characteristics and Risk Factors for Rebleeding in Patients with Obscure Gastrointestinal Bleeding.

    Yuki Baba, Seiji Kawano, Yoshiyasu Kono, Toshihiro Inokuchi, Hiromitsu Kanzaki, Masaya Iwamuro, Keita Harada, Sakiko Hiraoka, Yoshiro Kawahara, Hiroyuki Okada

    Internal medicine (Tokyo, Japan)   59 ( 11 )   1345 - 1350   2020年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Objective With the advent of capsule endoscopy (CE) and double-balloon endoscopy (DBE), the diagnosis and treatment of obscure gastrointestinal bleeding (OGIB) have markedly progressed. However, rebleeding sometimes occurs and is difficult to diagnose and treat. The aim of the present study was to investigate the clinical features of OGIB and risk factors for rebleeding in our hospital. Methods A total of 195 patients who underwent CE and/or DBE for OGIB in our hospital from January 2009 to July 2016 were included in the present study. We analyzed 168 cases of small intestinal OGIB, after excluding 27 cases of extra small intestinal bleeding. The clinical characteristics and risk factors related to rebleeding were retrospectively studied. Results Among the 168 patients who were included in the analysis, 95 patients (56.5%) were male. The mean age was 64.5 years (range, 8 to 87 years). Hypertension (31.0%) was the most frequent comorbidity, followed by chronic kidney disease (19.0%). The final diagnoses were ulcerative lesions (n=50, 29.8%), vascular lesions (n=30, 17.9%), tumors (n=7, 4.2%), and diverticula (n=2, 1.2%). The bleeding source was undetermined in the remaining 79 cases (47.0%). Rebleeding was confirmed in 29 cases (17.3%). In a univariate analysis, chronic kidney disease, vascular lesions, and overt previous bleeding were significantly associated with the risk of rebleeding. A multivariate analysis showed that chronic kidney disease, vascular lesion, and overt previous bleeding were significantly associated with the risk of rebleeding. Conclusion Patients with OGIB with overt previous bleeding, vascular lesions, and/or chronic kidney disease had a higher risk of rebleeding.

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  • Evaluation of the Usefulness and Convenience of the Kyoto Classification of Gastritis in the Endoscopic Diagnosis of the Helicobacter pylori Infection Status. 国際誌

    Hiroyuki Sakae, Masaya Iwamuro, Yuki Okamoto, Yuka Obayashi, Yuki Baba, Kenta Hamada, Tatsuhiro Gotoda, Makoto Abe, Yoshiyasu Kono, Hiromitsu Kanzaki, Seiji Kawano, Yoshiro Kawahara, Takehiro Tanaka, Hiroyuki Yanai, Hiroyuki Okada

    Digestion   101 ( 6 )   771 - 778   2020年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:KARGER  

    BACKGROUND/AIMS: The Kyoto Classification of Gastritis was published in 2014. Although this classification is now widely used in Japan, its usefulness and convenience have not been sufficiently evaluated. This study aimed to evaluate the usefulness and convenience of this classification in the endoscopic diagnosis of Helicobacter pylori infection. METHODS: We made a test for the endoscopic diagnosis of H. pylori infection comprising 30 cases who had representative endoscopic features of non-, active, or inactive gastritis. Thirty-eight participants took the test before and after a brief mini-lecture on the Kyoto Classification of Gastritis. Eighteen participants took the test again 3 months later. We investigated the accuracy before, just after, and 3 months after the mini-lecture. RESULTS: The accuracy of endoscopists after the lecture was significantly improved in comparison to before the lecture (77.6 vs. 83.3%). Medical students also showed significantly improved accuracy after the lecture (56.7 vs. 71.7%). Among endoscopists, this improvement was maintained after 3 months. Before the lecture, the accuracy of diagnosing non-gastritis was 90.3%; it tended to be further improved 3 months later (96.5%). A >10% point increase was observed in diagnosing active (72.7-83.3%) and inactive gastritis (73.2-84.3%) at 3 months after the lecture in comparison to before the lecture. CONCLUSION: A brief mini-lecture on the Kyoto Classification of Gastritis improved the accuracy in the endoscopic diagnosis of gastritis, indicating that understanding this classification is useful for the prompt diagnosis of H. pylori infection during esophagogastroduodenoscopy.

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  • Underwater endoscopic mucosal resection for a colonic polyp located at the scar after endoscopic band ligation. 国際誌

    Yoshiyasu Kono, Tetsuya Katayama, Koji Miyahara, Yuki Moritou, Reiji Higashi, Masaki Kunihiro, Masahiro Nakagawa

    Endoscopy   51 ( 7 )   E181-E182 - E182   2019年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:GEORG THIEME VERLAG KG  

    DOI: 10.1055/a-0875-3266

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  • A multicenter observational study on the clinicopathological features of gastric cancer in young patients.

    Yoshiyasu Kono, Hiromitsu Kanzaki, Takao Tsuzuki, Masahiro Takatani, Junichirou Nasu, Daisuke Kawai, Ryuta Takenaka, Takehiro Tanaka, Masaya Iwamuro, Seiji Kawano, Yoshiro Kawahara, Toshiyoshi Fujiwara, Hiroyuki Okada

    Journal of gastroenterology   54 ( 5 )   419 - 426   2019年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The details of gastric cancer in young patients remain unclear because of the low prevalence of the disease. This study aimed to clarify the clinicopathological features and prognosis of gastric cancer in young patients. METHODS: From January 2007 to January 2016, patients in their 20s and 30s who were diagnosed with primary gastric cancer at 4 hospitals were enrolled. Their clinical characteristics and prognosis were evaluated. RESULTS: The total number of patients was 72. The median age was 36 years, and the ratio of males to females was 1:1. The dominant histological type was undifferentiated type (66/72, 92%). Helicobacter pylori (H. pylori) was positive in 81% (54/67). Although there were some asymptomatic patients in stages I-III, all stage IV patients had some clinical symptoms at the diagnosis. The percentage of stage IV was significantly higher in patients in their 20s than in those in their 30s (75% vs. 25%, P < 0.001). The Kaplan-Meier method showed that the overall survival of patients in their 20s was significantly lower than that of patients in their 30s (P = 0.037). CONCLUSIONS: A high rate of H. pylori infection was revealed in young gastric cancer patients. The patients in their 20s had a worse prognosis than those in their 30s. We should consider examining the H. pylori infection status for young patients as well as older patients to identify high-risk populations.

    DOI: 10.1007/s00535-018-1525-4

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  • Intramucosal gastric cancer on the prepylorus completely resected by underwater endoscopic mucosal resection. 国際誌

    Hisahiro Uemura, Yoshiyasu Kono, Masahiro Nakagawa

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   31 ( 3 )   332 - 332   2019年5月

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    記述言語:英語   出版者・発行元:WILEY  

    DOI: 10.1111/den.13375

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  • Underwater endoscopic mucosal resection for gastric polyp. 国際誌

    Yoshiyasu Kono, Hiroyuki Sakae, Hiroyuki Okada

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society   30 ( 4 )   525 - 525   2018年7月

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    記述言語:英語  

    DOI: 10.1111/den.13068

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  • The Combination Use of an Acetic Acid Indigo Carmine Mixture and Linked-Color Imaging to Detect Early Gastric Cancer. 国際誌

    Yoshiyasu Kono, Yoshiro Kawahara, Hiroyuki Okada

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association   16 ( 6 )   e61   2018年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.cgh.2017.08.038

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  • On going OGIBに対する安全な緊急ダブルバルーン内視鏡止血術成功への取り組み

    川野 誠司, 岡本 雄貴, 大林 由佳, 榮 浩行, 安部 真, 後藤田 達洋, 河野 吉泰, 井口 俊博, 神崎 洋光, 岩室 雅也, 河原 祥朗, 岡田 裕之

    Gastroenterological Endoscopy   60 ( Suppl.1 )   686 - 686   2018年4月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • 超高齢者の早期胃癌に対するESDの安全性と有効性に関する検討

    後藤田 達洋, 川野 誠司, 岡本 雄貴, 馬場 雄己, 大林 由佳, 安部 真, 河野 吉泰, 神崎 洋光, 岩室 雅也, 田中 健大, 河原 祥朗, 岡田 裕之

    日本高齢消化器病学会誌   20 ( 2 )   57 - 63   2018年3月

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    記述言語:日本語   出版者・発行元:(NPO)日本高齢消化器病学会  

    高齢化社会の進展とともに85歳以上の超高齢者に対し胃ESDを行う機会が増加している。2009年9月から2016年6月に75歳以上の高齢者に対して当科でESDを施行した早期胃癌340例を対象とし、高齢者群(75歳以上85歳未満)、超高齢者群(85歳以上)の2群に分類し、両群における安全性と有効性を比較検討した。併存疾患、麻酔関連合併症発生率、偶発症発生率において両群間に有意差は認めず、85歳以上の超高齢者においてもESDの安全性が示唆された。病理組織学的な根治性評価および3年生存率において有意差はなく、ESDの有効性に関して超高齢者においても良好な成績が得られていた。胃ESDは超高齢者においても高齢者と同等の安全性、有効性が期待される。(著者抄録)

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  • Postoperative bleeding risk after gastric endoscopic submucosal dissection during antithrombotic drug therapy. 国際誌

    Yoshiyasu Kono, Yuka Obayashi, Yuki Baba, Hiroyuki Sakae, Tatsuhiro Gotoda, Ko Miura, Hiromitsu Kanzaki, Masaya Iwamuro, Seiji Kawano, Yoshiro Kawahara, Takehiro Tanaka, Hiroyuki Okada

    Journal of gastroenterology and hepatology   33 ( 2 )   453 - 460   2018年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND AND AIM: The safety of gastric endoscopic submucosal dissection (ESD) in the antithrombotic drug users remains controversial. METHODS: Patients who underwent gastric ESD at Okayama University Hospital between March 2006 and February 2016 were enrolled. This study investigated the risk of post-ESD bleeding according to the management of the antithrombotic drugs. RESULTS: One thousand twenty lesions (872 patients) were enrolled. In a multivariate analysis, heparin replacement (odds ratio [OR] 5.0, 95% confidence interval [CI] 1.8-14), multiple antithrombotic drug use (OR 2.9, 95% CI 1.1-6.9), a resected specimen of ≥ 33 mm in diameter (OR 2.7, 95% CI 1.5-5.4), Helicobacter pylori negativity (OR 2.2, 95% CI 1.3-3.7), and tumors located in the lower third of the stomach (OR 1.7, 95% CI 1.0-2.9) were significant risk factors for post-ESD bleeding, while the continuation of aspirin or cilostazol was not (OR 2.6, 95% CI 0.72-7.8). The bleeding rate of the continuation group was comparable with that of the all cessation group among single antithrombotic drug users (4.5% vs 4.4%, P = 1.0); however, the rate of the continuation group was significantly higher than that of the all cessation group among multiple antithrombotic drug users (67% vs 15%, P = 0.020). CONCLUSIONS: The risk of post-ESD bleeding differed according to the management of the antithrombotic drugs. The gastric ESD under the cessation or continuation of aspirin or cilostazol monotherapy was acceptable. However, multiple antithrombotic drug use or heparin replacement was associated with a higher risk of post-ESD bleeding.

    DOI: 10.1111/jgh.13872

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  • Clinical outcome of patients with obscure gastrointestinal bleeding during antithrombotic drug therapy. 国際誌

    Yoshiyasu Kono, Seiji Kawano, Yuki Okamoto, Yuka Obayashi, Yuki Baba, Hiroyuki Sakae, Makoto Abe, Tatsuhiro Gotoda, Toshihiro Inokuchi, Hiromitsu Kanzaki, Masaya Iwamuro, Yoshiro Kawahara, Hiroyuki Okada

    Therapeutic advances in gastroenterology   11   1756283X17746930   2018年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background: The clinical outcome of patients with obscure gastrointestinal bleeding (OGIB) during antithrombotic drug therapy has not been fully investigated. Methods: Patients who underwent video capsule endoscopy (VCE) for the investigation of OGIB at Okayama University Hospital from January 2009 to March 2016 were enrolled. We evaluated the VCE findings, the patterns of OGIB, and the rate of rebleeding within 1 year in antithrombotic drug users and antithrombotic drug nonusers. Results: A total of 181 patients were enrolled. Among the antithrombotic drug users, the rate of VCE positivity in the patients with overt OGIB was significantly higher in comparison with patients with occult OGIB (45% versus 16%, p = 0.014), whereas there was no significant difference among the antithrombotic drug nonusers (27% versus 26%, p = 1.0). Among the antithrombotic drug users, the rate of rebleeding among the VCE-positive patients was significantly higher in comparison with the VCE-negative patients (50% versus 5.9%, p = 0.011). Moreover, among antithrombotic drug users who did not receive therapeutic intervention, the rate of rebleeding among the VCE-positive patients was significantly higher in comparison with the VCE-negative patients (75% versus 6.3%, p = 0.001). However, among the antithrombotic drug nonusers who did not receive therapeutic intervention, the rebleeding rate of the VCE-positive patients was not significantly different from that of the VCE-negative patients (20% versus 9.4%, p = 0.43). Conclusion: Therapeutic intervention should be considered for patients with overt OGIB who are VCE positive and who use antithrombotic drugs due to the high risk of rebleeding.

    DOI: 10.1177/1756283X17746930

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  • Linked color imaging (LCI), a novel image-enhanced endoscopy technology, emphasizes the color of early gastric cancer. 国際誌

    Hiromitsu Kanzaki, Ryuta Takenaka, Yoshiro Kawahara, Daisuke Kawai, Yuka Obayashi, Yuki Baba, Hiroyuki Sakae, Tatsuhiro Gotoda, Yoshiyasu Kono, Ko Miura, Masaya Iwamuro, Seiji Kawano, Takehiro Tanaka, Hiroyuki Okada

    Endoscopy international open   5 ( 10 )   E1005-E1013   2017年10月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    Background and study aims:  Linked color imaging (LCI) and blue laser imaging (BLI) are novel image-enhanced endoscopy technologies with strong, unique color enhancement. We investigated the efficacy of LCI and BLI-bright compared to conventional white light imaging (WLI) by measuring the color difference between early gastric cancer lesions and the surrounding mucosa. Patients and methods:  Images of early gastric cancer scheduled for endoscopic submucosal dissection were captured by LCI, BLI-bright, and WLI under the same conditions. Color values of the lesion and surrounding mucosa were defined as the average of the color value in each region of interest. Color differences between the lesion and surrounding mucosa (ΔE) were examined in each mode. The color value was assessed using the CIE L*a*b* color space (CIE: Commission Internationale d'Eclairage). Results:  We collected images of 43 lesions from 42 patients. Average ΔE values with LCI, BLI-bright, and WLI were 11.02, 5.04, and 5.99, respectively. The ΔE was significantly higher with LCI than with WLI ( P  < 0.001). Limited to cases of small ΔE with WLI, the ΔE was approximately 3 times higher with LCI than with WLI (7.18 vs. 2.25). The ΔE with LCI was larger when the surrounding mucosa had severe intestinal metaplasia ( P  = 0.04). The average color value of a lesion and the surrounding mucosa differed. This value did not have a sufficient cut-off point between the lesion and surrounding mucosa to distinguish them, even with LCI. Conclusion:  LCI had a larger ΔE than WLI. It may allow easy recognition and early detection of gastric cancer, even for inexperienced endoscopists.

    DOI: 10.1055/s-0043-117881

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  • Clinicopathological features of gastric cancer in young patients; Multicenter retrospective study

    Yoshiyasu Kono, Hiromitsu Kanzaki, Masahiro Takatani, Junichirou Nasu, Ryuta Takenaka, Hiroyuki Sakae, Ko Miura, Takehiro Tanaka, Shunsuke Kagawa, Hiroyuki Okada

    ANNALS OF ONCOLOGY   28   2017年10月

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    記述言語:英語   出版者・発行元:OXFORD UNIV PRESS  

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  • 早期胃癌に対するLCI(linked color image)とAIM色素を併用した画像強調内視鏡(IEE)の有用性

    河原 祥朗, 神崎 洋光, 河野 吉泰, 後藤田 達洋, 岩室 雅也, 榮 浩行, 大林 由佳, 馬場 雄己, 川野 誠司, 田中 健大, 岡田 裕之

    Gastroenterological Endoscopy   59 ( Suppl.2 )   2132 - 2132   2017年9月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • Evaluation of the bleeding risk with various antithrombotic therapies after gastric endoscopic submucosal dissection. 国際誌

    Tatsuhiro Gotoda, Keisuke Hori, Masaya Iwamuro, Yoshiyasu Kono, Kou Miura, Hiromitsu Kanzaki, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada

    Endoscopy international open   5 ( 7 )   E653-E662   2017年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND AND STUDY AIMS : Patients receiving antithrombotic drugs have a higher risk of postoperative bleeding and thromboembolic events related to endoscopic procedures. The aim of this study was to evaluate the relationship between various antithrombotic therapies and bleeding after gastric endoscopic submucosal dissection (ESD) (post-ESD bleeding). PATIENTS AND METHODS:  Among 529 consecutive gastric ESD procedures (483 patients with 579 legions), 100 patients with 121 lesions who underwent 108 procedures were on antithrombotic therapy (group A) and 382 patients with 458 lesions who underwent 421 procedures were not on antithrombotic therapy (group B). The ratio of post-ESD bleeding between the two groups and the bleeding risk related to various antithrombotic therapies were investigated. RESULTS : Postoperative bleeding was more frequent in group A (11.1 %) than in group B (3.3 %). No thromboembolic events were reported in either group. Further investigation of antithrombotic therapies in group A demonstrated that various combinations of antithrombotic agents and heparin replacement were associated with a higher ratio of post-ESD bleeding. Multivariate analyses revealed that dual antiplatelet therapy (odds ratio [OR] 10.9, 95 % confidence interval [CI] 2.1 - 49.5; P  = 0.005) and heparin replacement (OR 34.4, 95 %CI 9.4 - 133.2; P  < 0.001) were associated with the increased risk of post-ESD bleeding. In patients on antiplatelet therapy, post-ESD bleeding tended to occur in the early postoperative period compared with patients on anticoagulant therapy. CONCLUSIONS:  It is necessary to be cautious regarding post-ESD bleeding in patients requiring antithrombotic therapy, especially patients receiving dual antiplatelet therapy and heparin replacement. A further prospective study with a large sample will be needed to confirm these findings.

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  • Citrobacter braakii bacteremia-induced septic shock after colonoscopy preparation with polyethylene glycol in a critically ill patient: a case report. 査読 国際誌

    Tetsuya Yumoto, Yoshiyasu Kono, Seiji Kawano, Chihiro Kamoi, Atsuyoshi Iida, Motoko Nose, Keiji Sato, Toyomu Ugawa, Hiroyuki Okada, Yoshihito Ujike, Atsunori Nakao

    Annals of clinical microbiology and antimicrobials   16 ( 1 )   22 - 22   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:BMC  

    BACKGROUND: Polyethylene glycol (PEG) is widely used for bowel cleaning in preparation for colonoscopy because of its safety. Septic shock after PEG preparation is an extremely rare complication. Herein, we describe a case of septic shock that occurred immediately after colonoscopy preparation with PEG. CASE PRESENTATION: A 75-year-old Japanese male who had previously developed diabetes after total pancreatectomy received PEG in preparation for colonoscopy. He had been admitted to the emergency intensive care unit 4 days earlier due to hematochezia presenting with shock. He ingested PEG to prepare for a colonoscopy examination, which was performed to identify the source of his bleeding over a 5-h period, but suddenly exhibited septic shock and markedly elevated procalcitonin levels. A blood culture subsequently revealed Citrobacter braakii. Immediate resuscitation and intensive care with appropriate antibiotics improved his condition. CONCLUSIONS: Clinicians should be aware of the possibility of deteriorating conditions after bowel preparation with PEG among severely ill patients with recent episodes of hemorrhagic shock.

    DOI: 10.1186/s12941-017-0201-5

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  • Erratum to: Multicenter Prospective Study on the Safety of Upper Gastrointestinal Endoscopic Procedures in Antithrombotic Drug Users. 国際誌

    Yoshiyasu Kono, Minoru Matsubara, Tatsuya Toyokawa, Ryuta Takenaka, Seiyu Suzuki, Junichirou Nasu, Masao Yoshioka, Masahiro Nakagawa, Motowo Mizuno, Hiroyuki Sakae, Makoto Abe, Tatsuhiro Gotoda, Ko Miura, Hiromitsu Kanzaki, Masaya Iwamuro, Keisuke Hori, Takao Tsuzuki, Masahide Kita, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada

    Digestive diseases and sciences   62 ( 4 )   1101 - 1102   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1007/s10620-017-4486-1

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  • Multicenter Prospective Study on the Safety of Upper Gastrointestinal Endoscopic Procedures in Antithrombotic Drug Users. 国際誌

    Yoshiyasu Kono, Minoru Matsubara, Tatsuya Toyokawa, Ryuta Takenaka, Seiyu Suzuki, Junichirou Nasu, Masao Yoshioka, Masahiro Nakagawa, Motowo Mizuno, Hiroyuki Sakae, Makoto Abe, Tatsuhiro Gotoda, Ko Miura, Hiromitsu Kanzaki, Masaya Iwamuro, Keisuke Hori, Takao Tsuzuki, Masahide Kita, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada

    Digestive diseases and sciences   62 ( 3 )   730 - 738   2017年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND: The Japan Gastroenterological Endoscopy Society updated its guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment in July 2012. However, the safety of endoscopic procedures in antithrombotic drug users has not been fully investigated. AIMS: To evaluate the safety of upper gastrointestinal endoscopic procedures in antithrombotic drug users. METHODS: From September 2013 to September 2015, patients who were taking antithrombotic drugs and who underwent upper gastrointestinal endoscopic procedures were prospectively enrolled at five hospitals. Incidences of bleeding and thrombosis during endoscopic procedures were evaluated. RESULTS: A total of 270 patients [221 for endoscopic mucosal biopsy and 49 for endoscopic mucosal resection (EMR)/endoscopic submucosal dissection (ESD) were enrolled. The bleeding rate was 0.9% for endoscopic mucosal biopsy and 22% for EMR/ESD, respectively. The bleeding rate after endoscopic mucosal biopsy was not significantly high, even if antithrombotic drugs were continued (0 vs. 1%, P > 0.99), while it was significantly higher among multiple antithrombotic drug users than single drug users (5.9 vs. 0%, P < 0.05). The bleeding rate after EMR/ESD was also higher among multiple antithrombotic drug users than single drug users, but was not significantly different (33 vs. 14%, P = 0.17). Moreover, there were no differences in bleeding rates according to the cessation or continuance of antithrombotic drugs (20 vs. 25%, P = 0.74). There were no thromboembolisms in all cases. CONCLUSIONS: Upper gastrointestinal endoscopic procedures performed under the new guidelines appear acceptable. However, endoscopic procedures among multiple antithrombotic drug users show a greater potential for bleeding.

    DOI: 10.1007/s10620-016-4437-2

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  • Oxidative stress controlling agents are effective for small intestinal injuries induced by non-steroidal anti-inflammatory drugs. 国際誌

    Yoshiyasu Kono, Seiji Kawano, Akinobu Takaki, Yasuyuki Shimomura, Masahiro Onji, Hisashi Ishikawa, Sakuma Takahashi, Joichiro Horii, Sayo Kobayashi, Daisuke Kawai, Kazuhide Yamamoto, Hiroyuki Okada

    Journal of gastroenterology and hepatology   32 ( 1 )   136 - 145   2017年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND AND AIM: Video-capsule endoscopy (VCE) has shown that intestinal ulcers are common in non-steroidal anti-inflammatory drugs (NSAIDs) users, although the mechanisms and management have not been clearly defined. To explore the contribution of oxidative stress and potential of anti-oxidants for NSAIDs-induced intestinal ulcers, we assessed human serum oxidative stress balance and the effect of anti-oxidants using a mouse model. METHODS: A total of 30 NSAIDs users (17 aspirin and 13 non-aspirin users) received VCE. Serum reactive oxygen metabolite (d-ROM) and antioxidative OXY-adsorbent test (OXY) were measured. The indomethacin (IND)-induced mouse intestinal ulcer model was used to assess the effect of anti-oxidants. Eight-week-old mice were divided into four groups; control diet and diet including IND (N group), IND and L-carnitine (NC group), and IND and vitamin E (NE group). RESULTS: Serum OXY levels among non-aspirin users were lower in the mucosal injuries positive group than the negative group (P < 0.05). In the mouse models, the degree of mucosal injuries was lower in NC and NE than N (P < 0.01). Serum d-ROM levels were lower in NC and NE than N (P < 0.01), and OXY levels were higher in NC than N and NE (P < 0.01). The degeneration of intestinal mitochondria was mild in NC and NE. The serum KC/CXCL-1 level and hepatic expression of the anti-oxidant molecule Gpx4 were lower in NC than N. CONCLUSIONS: Non-aspirin NSAID-induced intestinal ulcers are related to decreased anti-oxidative stress function. Anti-oxidants, especially L-carnitine, are good candidates for intestinal ulcers.

    DOI: 10.1111/jgh.13424

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  • Corrigendum to "Safety and Efficacy of Small Bowel Examination by Capsule Endoscopy for Patients before Liver Transplantation". 国際誌

    Seiji Kawano, Akinobu Takaki, Masaya Iwamuro, Tetsuya Yasunaka, Yoshiyasu Kono, Kou Miura, Toshihiro Inokuchi, Yoshiro Kawahara, Yuzo Umeda, Takahito Yagi, Hiroyuki Okada

    BioMed research international   2017   6418529 - 6418529   2017年

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    記述言語:英語  

    [This corrects the article DOI: 10.1155/2017/8193821.].

    DOI: 10.1155/2017/6418529

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  • Safety and Efficacy of Small Bowel Examination by Capsule Endoscopy for Patients before Liver Transplantation. 国際誌

    Kawano Seiji, Takaki Akinobu, Iwamuro Masaya, Yasunaka Tetsuya, Kono Yoshiyasu, Miura Kou, Inokuchi Toshihiro, Kawahara Yoshiro, Umeda Yuzo, Yagi Takahito, Okada Hiroyuki

    BioMed research international   2017   8193821 - 8193821   2017年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:HINDAWI LTD  

    Background and Aims. Gastrointestinal surveillance is a requirement prior to liver transplantation (LT), but small intestine examination is not generally undertaken. The aim of the present study was to evaluate the safety and efficacy of capsule endoscopy (CE) for patients with end-stage liver disease. Methods. 31 patients who needed LT were enrolled, and 139 patients who underwent CE over the same period of time acted as controls. Results. Frequency of successful achievement of evaluation of the full length of the small bowel, the mean gastric transit time, and the mean small bowel transit time were not significantly different between the two groups. Abnormalities in the small bowel were found in 26 patients. Comparative analysis revealed that history of EV rupture, history of EV treatment, red color sign of EV, and presence of PHG or HCC were significantly associated with patients with >2 two such findings (high score group). Conclusions. Small bowel examination by CE in patients before liver transplantation could be performed safely and is justified by the high rate of abnormal lesions detected particularly in patients with history of EV therapy or bleeding, red color sign, and presence of PHG or HCC. This study was registered in the UMIN Clinical Trial Registry (UMIN 000008672).

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  • 胃癌内視鏡治療後に適応外病変と診断された症例の転帰ならびにその長期成績

    三浦 公, 神崎 洋光, 榮 浩行, 後藤田 達洋, 河野 吉泰, 岩室 雅也, 川野 誠司, 河原 祥朗, 田中 健大, 岡田 裕之

    Gastroenterological Endoscopy   58 ( Suppl.2 )   1917 - 1917   2016年10月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • Propofol sedation with a target-controlled infusion pump and bispectral index monitoring system in elderly patients during a complex upper endoscopy procedure. 国際誌

    Tatsuhiro Gotoda, Hiroyuki Okada, Keisuke Hori, Yoshiro Kawahara, Masaya Iwamuro, Makoto Abe, Yoshiyasu Kono, Kou Miura, Hiromitsu Kanzaki, Masahide Kita, Seiji Kawano, Kazuhide Yamamoto

    Gastrointestinal endoscopy   83 ( 4 )   756 - 64   2016年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND AND AIMS: Although the usefulness of propofol sedation during endoscopic submucosal dissection (ESD) for gastric neoplasms was reported previously, information is limited on its use in elderly patients. We investigated the safety and efficacy of propofol sedation with a target-controlled infusion (TCI) pump and bispectral index (BIS) monitoring system (TCI/BIS system) in elderly patients during gastric ESD. METHODS: Included were 413 consecutive gastric ESD procedures involving 455 lesions (379 patients) performed in patients under propofol sedation with a TCI/BIS system between October 2009 and September 2013. Patients were divided into 3 groups: group A, age <70 years (n = 162); group B, age ≥70 and <80 years (n = 171); and group C, age ≥80 years (n = 80). We compared the propofol dose and adverse events (eg, hypotension and hypoxemia) during ESD. RESULTS: Older groups required a lower target concentration of propofol (group A: median 2.1 μg/mL [interquartile range (IQR), 1.9-2.3]; group B: median 1.6 μg/mL [IQR, 1.3-1.8]; and group C: median 1.4 μg/mL [IQR, 1.2-1.6]; P < .0001). Hypotension tended to occur in the younger group, and hypoxemia occurred at a significantly higher rate in the older groups, although the number of cases was small. Low preoperative systolic blood pressure (≤125 mm Hg) was associated with hypotension (odds ratio [OR], 1.73; 95% confidence interval [CI], 1.12-2.70; P = .013) and abnormal pulmonary function was associated with hypoxemia in groups B and C (OR, 4.54; 95% CI, 1.01-31.5; P = .048). CONCLUSIONS: Elderly patients required lower doses of propofol with the TCI/BIS system than younger patients. Attention to hypoxemia is necessary in elderly patients, particularly patients with abnormal pulmonary function.

    DOI: 10.1016/j.gie.2015.08.034

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  • Does Helicobacter pylori Exacerbate Gastric Mucosal Injury in Users of Nonsteroidal Anti-Inflammatory Drugs? A Multicenter, Retrospective, Case-Control Study. 国際誌

    Yoshiyasu Kono, Hiroyuki Okada, Ryuta Takenaka, Ko Miura, Hiromitsu Kanzaki, Keisuke Hori, Masahide Kita, Takao Tsuzuki, Seiji Kawano, Yoshiro Kawahara, Kazuhide Yamamoto

    Gut and liver   10 ( 1 )   69 - 75   2016年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    BACKGROUND/AIMS: The interaction between nonsteroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori remains controversial. We retrospectively investigated whether H. pylori infection exacerbates severe gastric mucosal injury among chronic NSAID users. METHODS: From January 2010 to December 2013, a total of 245 long-term NSAID (including low-dose aspirin) users who had undergone an esophagogastroduodenoscopy and had been evaluated for H. pylori infection were enrolled at Okayama University Hospital and Tsuyama Chuo Hospital. The degree of gastric mucosal injury was assessed according to the modified Lanza score (MLS). Severe gastric mucosal injury was defined as an MLS ≥4. Univariate and multivariate logistic regression analyses were performed. RESULTS: In the univariate analysis, age ≥75 years (odds ratio [OR], 2.4; 95% confidence interval [CI], 1.3 to 4.2), H. pylori-positivity (OR, 2.0; 95% CI, 1.2 to 3.5), and the concomitant use of proton pump inhibitors (PPIs) (OR, 0.48; 95% CI, 0.26 to 0.86) were significantly associated with severe gastric mucosal injury. The multivariate analysis was adjusted by age and sex and demonstrated that H. pylori-positivity (OR, 1.8; 95% CI, 1.0 to 3.3) and the concomitant use of PPIs (OR, 0.53; 95% CI, 0.28 to 0.99) significantly contributed to severe gastric mucosal injury. CONCLUSIONS: H. pylori infection exacerbates severe gastric mucosal injury among chronic NSAID users.

    DOI: 10.5009/gnl14372

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  • 集学的治療により長期生存が得られた食道神経内分泌癌の2例

    後藤田 達洋, 川野 誠司, 河野 吉泰, 三浦 公, 神崎 洋光, 岩室 雅也, 河原 祥朗, 田中 健大, 吉野 正, 白川 靖博, 田端 雅弘, 谷本 光音, 岡田 裕之

    岡山医学会雑誌   128 ( 3 )   207 - 212   2016年

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    記述言語:日本語   出版者・発行元:岡山医学会  

    Esophageal neuroendocrine carcinoma (ECC) is rare and has a poor prognosis when presenting with vascular invasion and distant metastasis from an early stage. Multidisciplinary therapy with surgery, chemotherapy, and radiation therapy may prolong survival in patients with advanced ECC, but there is as yet no standard therapy for advanced ECC. We treated two patients who have achieved long-term survival (> 4 years) who underwent multidisciplinary therapy, including chemotherapy, for ECC. Our experience with these two cases suggests that multidisciplinary therapy, including chemotherapy, may be effective for treating ECC at an advanced stage.

    DOI: 10.4044/joma.128.207

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  • Polycythemia vera diagnosed after esophageal variceal rupture

    Yoshiyasu Kono, Akinobu Takaki, Hideo Gobara, Ken Ichi Matsuoka, Masato Nishino, Hiroyuki Okada, Kazuhide Yamamoto

    Internal Medicine   54 ( 18 )   2395 - 2399   2015年9月

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    掲載種別:研究論文(学術雑誌)  

    Polycythemia vera (PV) is a chronic myeloproliferative neoplasm that leads to hyperviscosity and the risk of thrombosis. We encountered the case of a young male Filipino patient diagnosed with PV after the rupture of esophageal varices. The complete blood cell count showed a slight increase in white blood cells. An abdominal computed tomography scan disclosed splenomegaly and occlusion of the portal vein and collateral vessels. A blood examination demonstrated an increase in all three blood cell lines within three months. Based on the presence of severe hypercellularity of the bone marrow and positivity for the JAK2V617F mutation, we finally diagnosed the patient with PV.

    DOI: 10.2169/internalmedicine.54.4687

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  • A Randomized Trial of Monopolar Soft-mode Coagulation Versus Heater Probe Thermocoagulation for Peptic Ulcer Bleeding. 国際誌

    Tomokazu Nunoue, Ryuta Takenaka, Keisuke Hori, Noriko Okazaki, Kenta Hamada, Yuki Baba, Yasushi Yamasaki, Yoshiyasu Kono, Hiroyuki Seki, Toshihiro Inokuchi, Koji Takemoto, Akihiko Taira, Hirofumi Tsugeno, Shigeatsu Fujiki, Yoshiro Kawahara, Hiroyuki Okada

    Journal of clinical gastroenterology   49 ( 6 )   472 - 6   2015年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:LIPPINCOTT WILLIAMS & WILKINS  

    BACKGROUND AND AIM: Endoscopic therapy has been demonstrated to be effective in achieving hemostasis for bleeding peptic ulcers. Thermal coagulation is one of the most commonly used methods, with a high success rate. Recently, endoscopic submucosal dissection for early gastric carcinoma was developed and hemostasis with soft coagulation using hemostatic forceps was introduced. The aim of this study was to compare the hemostatic efficacy of soft coagulation with heater probe thermocoagulation for peptic ulcer bleeding. METHODS: Patients who visited our hospital with hematemesis or melena underwent emergency endoscopy. Inclusion criteria were presentation with an actively bleeding ulcer, a nonbleeding visible vessel, or an adherent clot. Patients were excluded if they were unwilling to give written informed consent or had a bleeding gastric malignancy. Patients were randomized to receive endoscopic hemostasis with soft coagulation (Group S) or heater probe thermocoagulation (Group H). The primary endpoint was the primary hemostasis rate and secondary endpoints were rebleeding rate, complications, and the procedure time. RESULTS: Between May 2010 and February 2012, a total of 111 patients (89 gastric ulcers and 22 duodenal ulcers) were enrolled. Primary hemostasis was achieved in 54 patients (96%) in Group S and 37 (67%) in Group H (P<0.0001). Rebleeding occurred in 7 patients in Group H and none in Group S. Of these 7 patients, urgent surgery was performed in 1. Perforation occurred in 2 patients in Group H, which was managed conservatively. CONCLUSIONS: For patients with gastroduodenal ulcer bleeding, soft coagulation using monopolar hemostatic forceps is more effective than heater probe thermocoagulation for achieving hemostasis.

    DOI: 10.1097/MCG.0000000000000190

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  • Intramucosal gastric mixed adenoneuroendocrine carcinoma completely resected with endoscopic submucosal dissection.

    Yasushi Yamasaki, Junichiro Nasu, Kou Miura, Yoshiyasu Kono, Hiromitsu Kanzaki, Keisuke Hori, Takehiro Tanaka, Masahide Kita, Takao Tsuzuki, Minoru Matsubara, Seiji Kawano, Yoshiro Kawahara, Masahiro Tabata, Hiroyuki Okada, Kazuhide Yamamoto

    Internal medicine (Tokyo, Japan)   54 ( 8 )   917 - 20   2015年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC INTERNAL MEDICINE  

    Composite tumors in the stomach composed of adenocarcinoma and neuroendocrine carcinoma are rare. We herein report a case of intramucosal gastric mixed adenoneuroendocrine carcinoma (MANEC) that was treated with endoscopic submucosal dissection (ESD). A 77-year-old man who had previously received ESD for early gastric adenocarcinoma underwent esophagogastroduodenoscopy for screening, which showed a depressed lesion on the lesser curvature of the antrum. The tumor was removed en bloc via ESD and pathologically diagnosed as MANEC. The tumor was located within the mucosal layer, and no lymphovascular invasion was evident. Seven months after the ESD procedure, the patient is currently feeling well without recurrence or metastasis.

    DOI: 10.2169/internalmedicine.54.3469

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  • Monopolar Soft-Mode Coagulation Using Hemostatic Forceps for Peptic Ulcer Bleeding

    Yasushi Yamasaki, Ryuta Takenaka, Tomokazu Nunoue, Yoshiyasu Kono, Koji Takemoto, Akihiko Taira, Hirofumi Tsugeno, Shigeatsu Fujiki

    HEPATO-GASTROENTEROLOGY   61 ( 136 )   2272 - 2276   2014年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:H G E UPDATE MEDICAL PUBLISHING S A  

    Background/Aims: Upper gastrointestinal hemorrhage from bleeding peptic ulcer is sometimes difficult to treat by conventional endoscopic methods. Recently, monopolar electrocoagulation using a soft-coagulation system and hemostatic forceps (soft coagulation) has been used to prevent bleeding during endoscopic submucosal dissection. The aim of this study was to assess the safety and efficacy of soft coagulation in the treatment of bleeding peptic ulcer. Methodology: A total of 39 patients with peptic ulcers were treated using soft coagulation at our hospital between January 2005 and March 2010. Emergency treatment employed an ERBE soft-mode coagulation system using hemostatic forceps. Second-look endoscopy was performed to evaluate the efficacy of prior therapy. Initial hemostasis was defined as accomplished by soft coagulation, with or without other endoscopic therapy prior to soft coagulation. The rate of initial hemostasis, rebleeding, and ultimate hemostasis were retrospectively analyzed. Results: The study subjects were 31 men and 8 women with a mean age of 68.3 +/- 13.7 years, with 29 gastric ulcers and 10 duodenal ulcers. Initial hemostasis was achieved in 37 patients (95%). During follow-up, bleeding recurred in two patients, who were retreated with soft coagulation. Conclusions: The monopolar soft coagulation is feasible and safe for treating bleeding peptic ulcers.

    DOI: 10.5754/hge13780

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  • Chromoendoscopy of gastric adenoma using an acetic acid indigocarmine mixture. 国際誌

    Yoshiyasu Kono, Ryuta Takenaka, Yoshiro Kawahara, Hiroyuki Okada, Keisuke Hori, Seiji Kawano, Yasushi Yamasaki, Koji Takemoto, Takayoshi Miyake, Shigeatsu Fujiki, Kazuhide Yamamoto

    World journal of gastroenterology   20 ( 17 )   5092 - 7   2014年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    AIM: To investigate the usefulness of chromoendoscopy, using an acetic acid indigocarmine mixture (AIM), for gastric adenoma diagnosed by forceps biopsy. METHODS: A total of 54 lesions in 45 patients diagnosed as gastric adenoma by forceps biopsy were prospectively enrolled in this study and treated by endoscopic submucosal dissection (ESD) between January 2011 and January 2012. AIM-chromoendoscopy (AIM-CE) was performed followed by ESD. AIM solution was sprinkled and images were recorded every 30 s for 3 min. Clinical characteristics such as tumor size (< 2 cm, ≥ 2 cm), surface color in white light endoscopy (WLE) (whitish, normochromic or reddish), macroscopic appearance (flat or elevated, depressed), and reddish change in AIM-CE were selected as valuables. RESULTS: En bloc resection was achieved in all 54 cases, with curative resection of fifty two lesions (96.3%). Twenty three lesions (42.6%) were diagnosed as well-differentiated adenocarcinoma and the remaining 31 lesions (57.4%) were gastric adenoma. All adenocarcinoma lesions were well-differentiated tubular adenocarcinomas and were restricted within the mucosal layer. The sensitivity of reddish color change in AIM-CE is significantly higher than that in WLE (vs tumor size ≥ 2 cm, P = 0.016, vs normochromic or reddish surface color, P = 0.046, vs depressed macroscopic type, P = 0.0030). On the other hand, no significant differences were found in the specificity and accuracy. In univariate analysis, normochromic or reddish surface color in WLE (OR = 3.7, 95%CI: 1.2-12, P = 0.022) and reddish change in AIM-CE (OR = 14, 95%CI: 3.8-70, P < 0.001) were significantly related to diagnosis of early gastric cancer (EGC). In multivariate analysis, only reddish change in AIM-CE (OR = 11, 95%CI: 2.3-66, P = 0.0022) was a significant factor associated with diagnosis of EGC. CONCLUSION: AIM-CE may have potential for screening EGC in patients initially diagnosed as gastric adenoma by forceps biopsy.

    DOI: 10.3748/wjg.v20.i17.5092

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  • 当院における消化管神経内分泌腫瘍(NET)の治療成績

    筑木 隆雄, 岡田 裕之, 山本 和秀, 河原 祥朗, 那須 淳一郎, 平岡 佐規子, 原田 馨太, 松原 稔, 喜多 雅英, 堀 圭介, 秋田 光洋, 高橋 索真, 神崎 洋光, 井口 俊博, 三浦 公, 河野 吉泰, 半井 明日香, 森藤 由記, 竹井 大介

    Gastroenterological Endoscopy   56 ( Suppl.1 )   1339 - 1339   2014年4月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • 術後9年目の局所再発に対してNBI観察がなされた直腸悪性黒色腫の1例

    高原 政宏, 今川 敦, 河野 吉泰, 今田 貴之, 八木 覚, 宮武 宏和, 中津 守人, 安東 正晴, 広畑 衛, 宮谷 克也

    日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy   54 ( 9 )   3172 - 3177   2012年9月

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    記述言語:日本語   出版者・発行元:Japan Gastroenterological Endoscopy Society  

    症例は80歳代女性.血便精査で下部消化管内視鏡検査施行したところ,直腸Rbに15mmの褐色調隆起性病変を認めた.NBI観察でpit様構造は消失と整な構造が混在,またCorkscrew様の異常血管を認めた.悪性黒色腫を疑い十分なinformed consent後にEMRを施行し,病理組織学的所見で悪性黒色腫と診断した.9年前に同疾患で経肛門的切除術施行,断端陽性で不完全切除であったが,追加切除されておらず,同部位の局所再発と思われた.悪性黒色腫の予後は極めて悪く,また不完全切除例での長期生存例は稀である.更に,NBI観察しえたことから貴重な症例であると思われた.

    DOI: 10.11280/gee.54.3172

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    その他リンク: http://search.jamas.or.jp/link/ui/2013022294

  • Repeat Endoscopic Submucosal Dissection for Locally Recurring Gastric Cancers

    Ryuta Takenaka, Yoshiro Kawahara, Atsushi Imagawa, Yasushi Yamasaki, Yoshiyasu Kono, Koji Takemoto, Akihiko Taira, Hirofumi Tsugeno, Shigeatsu Fujiki

    GASTROINTESTINAL ENDOSCOPY   75 ( 4 )   244 - 244   2012年4月

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    記述言語:英語   出版者・発行元:MOSBY-ELSEVIER  

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  • 当院におけるGIST症例の検討

    河野 吉泰, 豊川 達也, 松本 和幸, 高原 政宏, 今田 貴之, 八木 覚, 宮武 宏和, 中津 守人, 安東 正晴, 廣畑 衛

    香川県内科医会誌   45   47 - 52   2009年6月

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    記述言語:日本語   出版者・発行元:香川県内科医会  

    Gastrointestinal stromal tumor(以下GIST)は全消化管切除腫瘍の0.5〜1.0%程度を占める稀な腫瘍である。今回我々は当院において病理組織学的にGISTと診断された19例を対象とし、その臨床的および病理学的特徴について検討した。発生部位は胃が14例と最多で、全体的に無症状で発見される例が多かった。手術標本の病理組織で診断されたものが13例と大部分を占めていた。腫瘍の大きさ・核分裂指数により評価した臨床的悪性度に基づきリスク分類を行った。転移・再発に関しては全て高リスク例であり、よく相関していた。予後に関しては、高リスク6例のうち死亡転帰は2例であり、リスク分類のみで予後を推測することは困難であった。予後不良因子として腹膜病変が示唆された。術前・術後化学療法の有効性や術後の適切な経過観察期間など、GISTに関して未だに臨床研究段階の項目は多く、今後さらなる症例数の集積が望まれる。(著者抄録)

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  • 当院における切除不能・再発胃がん症例に対するS-1+CDDP併用療法の検討

    今田 貴之, 豊川 達也, 篠井 尚子, 恒光 美穂, 三宅 智子, 河野 吉泰, 中野 由加里, 氏家 はる代, 竹内 洋平, 小西 順, 堀元 直哉, 松本 和幸, 高原 政宏, 八木 覚, 宮武 宏和, 中津 守人, 安東 正晴

    日本消化器病学会雑誌   106 ( 臨増総会 )   A178 - A178   2009年3月

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    記述言語:日本語   出版者・発行元:(一財)日本消化器病学会  

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  • 当院におけるGIST症例の検討

    河野 吉泰, 豊川 達也, 松本 和幸, 高原 政宏, 今田 貴之, 八木 覚, 宮武 宏和, 中津 守人, 安東 正晴

    日本消化器病学会雑誌   106 ( 臨増総会 )   A325 - A325   2009年3月

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    記述言語:日本語   出版者・発行元:(一財)日本消化器病学会  

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  • B型慢性肝炎急性増悪重症例に対しエンテカビルとステロイドを併用し奏効した2例

    宮武 宏和, 三宅 康広, 松本 和幸, 河野 吉泰, 竹内 洋平, 氏家 はる代, 中野 由加理, 小西 順, 高原 政宏, 今田 貴之, 八木 覚, 豊川 達也, 中津 守人, 安東 正晴, 廣畑 衛

    日本消化器病学会雑誌   106 ( 臨増総会 )   A465 - A465   2009年3月

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    記述言語:日本語   出版者・発行元:(一財)日本消化器病学会  

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  • 当院における食道癌化学放射線治療の検討

    松本 和幸, 豊川 達也, 河野 吉泰, 氏家 はる代, 中野 由加里, 小西 順, 高原 政宏, 今田 貴之, 八木 覚, 宮武 宏和, 中津 守人, 安東 正晴, 広畑 衛

    日本消化器病学会雑誌   106 ( 臨増総会 )   A185 - A185   2009年3月

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    記述言語:日本語   出版者・発行元:(一財)日本消化器病学会  

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  • 当院におけるGIST症例の検討

    河野 吉泰, 豊川 達也, 小西 順, 松本 和幸, 高原 政宏, 今田 貴之, 八木 覚, 宮武 宏和, 中津 守人, 安東 正晴, 廣畑 衛

    香川県医師会誌   61 ( 特別 )   67 - 67   2008年10月

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    記述言語:日本語   出版者・発行元:(一社)香川県医師会  

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  • 消化管細菌叢と胃の疾患 胃癌患者の胃内より分離される硝酸塩還元菌ついて

    横田 憲治, 倉岡 紗樹子, 岡上 昇太郎, 河野 吉泰, 岡田 裕之

    日本ヘリコバクター学会学術集会プログラム・抄録集   29回   95 - 95   2023年6月

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    記述言語:日本語   出版者・発行元:(一社)日本ヘリコバクター学会  

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  • 薬剤性消化管障害の最前線(下部) 当院における免疫関連有害事象(irAE)腸炎に関する検討

    平田 翔一郎, 河野 吉泰, 岩室 雅也

    Gastroenterological Endoscopy   65 ( Suppl.1 )   785 - 785   2023年4月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • 鎮静プロトコールに沿った、上部ESDにおける鎮静内容の検討

    神尾 知宏, 川野 誠司, 平井 亮佑, 小橋 真由, 倉岡 紗樹子, 岡上 昇太郎, 里見 拓也, 松枝 克典, 稲生 祥子, 河野 吉泰, 濱田 健太, 岩室 雅也, 河原 祥朗

    Gastroenterological Endoscopy   65 ( Suppl.1 )   899 - 899   2023年4月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • 上部消化管内視鏡検査時の苦痛に関する前向き観察研究

    神崎 洋光, 倉岡 沙樹子, 里見 拓也, 岡上 昇太郎, 濱田 健太, 河野 吉泰, 岩室 雅也, 川野 誠司, 河原 祥朗, 岡田 裕之

    Gastroenterological Endoscopy   65 ( Suppl.1 )   900 - 900   2023年4月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • 条件付き承認レジメンの意義 胃癌二次化学療法における条件付き推奨レジメンの検討

    河野 吉泰, 神崎 洋光, 平田 翔一郎, 稲生 祥子, 倉岡 紗樹子, 岡上 昇太郎, 里見 拓也, 松枝 克典, 濱田 健太, 岩室 雅也, 川野 誠司, 河原 祥朗

    日本胃癌学会総会記事   95回   218 - 218   2023年2月

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    記述言語:日本語   出版者・発行元:(一社)日本胃癌学会  

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  • Helicobacter pylori感染胃炎における硝酸塩還元菌の胃内生息状況に関する検討

    倉岡 紗樹子, 横田 憲治, 榮 浩行, 小嶋 日菜子, 岡上 昇太郎, 河野 吉泰, 岡田 裕之

    日本ヘリコバクター学会誌   24 ( 2 )   110 - 116   2023年1月

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    記述言語:日本語   出版者・発行元:(一社)日本ヘリコバクター学会  

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  • 高齢者消化器癌診療における化学療法と外科治療の現状と課題 高齢者消化器癌の化学療法開始前における高齢者機能評価と治療内容・予後についての検討

    河野 吉泰, 稲生 祥子, 堀口 繁, 加藤 博也, 倉岡 紗樹子, 岡上 昇太郎, 里見 拓也, 松枝 克典, 濱田 健太, 岩室 雅也, 川野 誠司, 河原 祥朗

    日本消化管学会雑誌   7 ( Suppl. )   219 - 219   2023年1月

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    記述言語:日本語   出版者・発行元:(一社)日本消化管学会  

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  • 造血幹細胞移植後に酢酸亜鉛二水和物(ノベルジン)の副作用として胃潰瘍を認めた1例

    平岡 凌河, 岩室 雅也, 濱田 健太, 河野 吉泰, 川野 誠司, 河原 祥朗

    日本消化器病学会中国支部例会・日本消化器内視鏡学会中国支部例会プログラム・抄録集   118回・129回   122 - 122   2022年11月

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    記述言語:日本語   出版者・発行元:日本消化器病学会-中国支部  

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  • H.heilmannii感染胃炎に発症した同時性多発早期胃癌の1例

    神尾 知宏, 河野 吉泰, 稲生 祥子, 倉岡 紗樹子, 岡上 昇太郎, 里見 拓也, 濱田 健太, 岩室 雅也, 川野 誠司, 田中 健大, 村山 そう明, 中村 正彦, 河原 祥朗

    日本消化器病学会中国支部例会・日本消化器内視鏡学会中国支部例会プログラム・抄録集   118回・129回   112 - 112   2022年11月

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  • 酢酸亜鉛起因性胃粘膜傷害の1例

    岩室 雅也, 河野 吉泰, 田中 健大, 濱田 健太, 神崎 洋光, 川野 誠司, 河原 祥朗, 岡田 裕之

    日本消化器病学会雑誌   119 ( 9 )   853 - 857   2022年9月

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    記述言語:日本語   出版者・発行元:(一財)日本消化器病学会  

    82歳男性.食後の胃もたれを主訴に上部消化管内視鏡検査を実施.胃体部小彎に白苔付着をともなうびらんと周囲に発赤を認め,生検で中分化管状腺癌が疑われたため当院紹介となった.初回より3週間後の内視鏡検査では,体部小彎の異なる位置に白苔付着をともなうびらんを認め,生検では非腫瘍であった.酢酸亜鉛起因性胃粘膜傷害を疑い,同薬剤の内服を中止したところ,胃粘膜傷害は改善した.(著者抄録)

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    その他リンク: https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J01118&link_issn=&doc_id=20220922450009&doc_link_id=1390574876232671104&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390574876232671104&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_2.gif

  • H.pylori未感染胃粘膜を背景に発生したリンパ節転移を伴う低分化型進行胃癌の一例

    倉岡 紗樹子, 川野 誠司, 小橋 真由, 岡上 昇太郎, 里見 拓也, 稲生 祥子, 濱田 健太, 河野 吉泰, 神崎 洋光, 岩室 雅也, 河原 祥朗, 岡田 裕之, 垣内 慶彦, 黒田 新士, 藤原 俊義, 田中 健大, 池田 宣聖

    日本消化器病学会中国支部例会プログラム・抄録集   117回   75 - 75   2022年6月

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  • Helicobacter suis感染胃炎の一例

    稲生 祥子, 岩室 雅也, 田中 健大, 倉岡 紗樹子, 岡上 昇太郎, 里見 拓也, 濱田 健太, 河野 吉泰, 神崎 洋光, 川野 誠司, 河原 祥朗, 岡田 裕之

    日本消化器病学会中国支部例会プログラム・抄録集   117回   74 - 74   2022年6月

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    記述言語:日本語   出版者・発行元:日本消化器病学会-中国支部  

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  • Helicobacter pylori感染胃炎における硝酸塩還元菌の胃内生息状況に関する検討

    倉岡 紗樹子, 横田 憲治, 榮 浩行, 小嶋 日菜子, 岡上 昇太郎, 河野 吉泰, 岡田 裕之

    日本ヘリコバクター学会学術集会プログラム・抄録集   28回   106 - 106   2022年6月

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    記述言語:日本語   出版者・発行元:(一社)日本ヘリコバクター学会  

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  • ヘリコバクター感染の基礎研究の現況 Helicobacter pyloriと共培養される胃内硝酸塩還元菌の細胞に対する作用

    小嶋 日菜子, 倉岡 沙樹子, 岡上 昇太郎, 河野 吉泰, 岡田 裕之, 横田 憲治

    日本ヘリコバクター学会学術集会プログラム・抄録集   28回   85 - 85   2022年6月

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  • 下咽頭ESD後の変形予防にValsalva法が有効であった1例

    佐藤 大直, 濱田 健太, 安部 真, 牧野 琢丸, 藤澤 郁, 岡上 昇太郎, 河野 吉泰, 神崎 洋光, 岩室 雅也, 川野 誠司, 河原 祥朗, 岡田 裕之

    日本消化器内視鏡学会中国支部例会   128回   101 - 101   2022年5月

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  • Heller-Dor術後に残存した胸痛に対し、Peroral Endoscopic Myotomyが有効であった食道アカラシアの一例

    平田 翔一郎, 里見 拓也, 濱田 健太, 榮 浩行, 杉原 雄策, 和田 薫, 桑井 寿雄, 稲生 祥子, 倉岡 紗樹子, 岡上 昇太郎, 河野 吉泰, 神崎 洋光, 岩室 雅也, 川野 誠司, 河原 祥朗, 岡田 裕之

    日本消化器内視鏡学会中国支部例会   128回   110 - 110   2022年5月

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  • チエノピリジン服用者における胃内視鏡的粘膜下層剥離術(ESD)の後出血リスクの検討

    平井 亮佑, 川野 誠司, 稲生 祥子, 倉岡 紗樹子, 岡上 昇太郎, 里見 拓也, 濱田 健太, 河野 吉泰, 神崎 洋光, 岩室 雅也, 河原 祥朗, 岡田 裕之

    Gastroenterological Endoscopy   64 ( Suppl.1 )   831 - 831   2022年4月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • 消化管出血に対する診療の進歩 左心耳閉鎖術前後の抗血栓療法に伴う消化管出血に関する検討

    河野 吉泰, 濱田 健太, 安部 真, 神崎 洋光, 岩室 雅也, 川野 誠司, 河原 祥朗, 岡田 裕之

    日本消化管学会雑誌   6 ( Suppl. )   188 - 188   2022年1月

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    記述言語:日本語   出版者・発行元:(一社)日本消化管学会  

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  • 若年者におけるヘリコバクターピロリ除菌治療による腸内細菌叢の変化についての検討

    岡上昇太郎, 後藤和義, 倉岡紗樹子, 稲生祥子, 里見拓也, 濱田健太, 河野吉泰, 神崎洋光, 岩室雅也, 川野誠司, 河原祥朗, 横田憲治, 岡田裕之

    日本ヘリコバクター学会学術集会プログラム・抄録集   28th   103 - 103   2022年

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    記述言語:日本語   出版者・発行元:(一社)日本ヘリコバクター学会  

    J-GLOBAL

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  • 胃癌と非癌粘膜の白色球状外観(white globe appearance)の差異に関する検討

    岩室雅也, 田中健大, 榮浩行, 安部真, 河野吉泰, 神崎洋光, 川野誠司, 河原祥朗, 岡田裕之

    Gastroenterological Endoscopy (Web)   64 ( 1 )   2022年

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  • チエノピリジン服用者における胃内視鏡的粘膜下層剥離術(ESD)の後出血リスクの検討

    平井亮佑, 川野誠司, 稲生祥子, 倉岡紗樹子, 岡上昇太郎, 里見拓也, 濱田健太, 河野吉泰, 神崎洋光, 岩室雅也, 河原祥朗, 岡田裕之

    Gastroenterological Endoscopy (Web)   64 ( Supplement1 )   2022年

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  • 家族性大腸腺腫症の胃病変の形質発現と内視鏡的特徴の検討

    小橋 真由, 岩室 雅也, 亀高 大介, 岡上 昇太郎, 里見 拓也, 濱田 健太, 榮 浩行, 安部 真, 河野 吉泰, 神崎 洋光, 川野 誠司, 河原 祥朗, 田中 健大, 岡田 裕之

    Gastroenterological Endoscopy   63 ( Suppl.2 )   2023 - 2023   2021年10月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • 【消化管の希少疾患-診療の現状】Gastric adenocarcinoma and proximal polyposis of the stomach(GAPPS)の臨床病理学的特徴

    川野 誠司, 赤穂 宗一郎, 倉岡 紗樹子, 小橋 真由, 岡上 昇太郎, 里見 拓也, 濱田 健太, 安部 真, 河野 吉泰, 神崎 洋光, 岩室 雅也, 河原 祥朗, 岡田 裕之

    消化器・肝臓内科   10 ( 3 )   290 - 295   2021年9月

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    記述言語:日本語   出版者・発行元:(有)科学評論社  

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  • 胃気腫症の5例の臨床的特徴に関する検討

    岩室 雅也, 安部 真, 河野 吉泰, 神崎 洋光, 堀 圭介, 川野 誠司, 河原 祥朗, 岡田 裕之

    日本消化器病学会雑誌   118 ( 9 )   851 - 858   2021年9月

  • Helicobacter pylori感染胃炎における硝酸塩還元菌の胃内生息状況に関する検討

    倉岡 紗樹子, 横田 憲治, 榮 浩行, 岡上 昇太郎, 河野 吉泰, 岡田 裕之

    日本ヘリコバクター学会学術集会プログラム・抄録集   27回   196 - 196   2021年9月

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    記述言語:日本語   出版者・発行元:(一社)日本ヘリコバクター学会  

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  • 胃炎の内視鏡診断最前線〜胃炎の京都分類からみた内視鏡所見と病理所見との対比 Linked Color Imaging(LCI)はH.pylori除菌前後の胃粘膜の色調変化を強調する

    榮 浩行, 倉岡 紗樹子, 岡上 昇太郎, 大林 由佳, 河野 吉泰, 三浦 公, 岡田 裕之

    日本ヘリコバクター学会学術集会プログラム・抄録集   27回   170 - 170   2021年9月

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    記述言語:日本語   出版者・発行元:(一社)日本ヘリコバクター学会  

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  • 女性に発症した食道扁平上皮癌の臨床病理学的特徴に関する検討

    小橋 真由, 川野 誠司, 倉岡 紗樹子, 岡上 昇太郎, 里見 拓也, 濱田 健太, 安部 真, 河野 吉泰, 神崎 洋光, 岩室 雅也, 河原 祥朗, 田邊 俊介, 藤原 俊義, 田中 健大, 岡田 裕之

    日本高齢消化器病学会誌   24 ( 1 )   186 - 186   2021年7月

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    記述言語:日本語   出版者・発行元:(NPO)日本高齢消化器病学会  

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  • 消化管の希少疾患-診療の現状 Gastric adenocarcinoma and proximal polyposis of the stomach(GAPPS)の臨床病理学的特徴

    川野誠司, 赤穂宗一郎, 倉岡紗樹子, 小橋真由, 岡上昇太郎, 里見拓也, 濱田健太, 安部真, 河野吉泰, 神崎洋光, 岩室雅也, 河原祥朗, 岡田裕之

    月刊消化器・肝臓内科   10 ( 3 )   2021年

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  • 【Helicobacter Topics!-「旬のHelicobacter」を知り、驚き、理解を深め、楽しむ-】近年の若年者胃がんにおけるHelicobacter pylori感染

    河野 吉泰, 神崎 洋光, 岡田 裕之

    Helicobacter Research   24 ( 2 )   193 - 196   2020年12月

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    記述言語:日本語   出版者・発行元:(株)先端医学社  

    胃がんは稀ながら40歳未満の若年者にも発症し、中高年者における胃がんと同様にHelicobacter pylori感染が大きな要因である。中高年者における胃がんとは異なった臨床病理学的・遺伝子学的特徴を有しており、進行期で診断されることが多く予後不良であるため、若年期からのH.pylori感染状態チェックと除菌治療による予防が必要である。(著者抄録)

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    その他リンク: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J03103&link_issn=&doc_id=20210216390011&doc_link_id=%2Fae6helib%2F2020%2F002402%2F013%2F0193-0196%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fae6helib%2F2020%2F002402%2F013%2F0193-0196%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • POEMが有効であったJackhammer esophagusの2例

    榮 浩行, 杉原 雄策, 里見 拓也, 岡上 昇太郎, 濱田 健太, 安部 真, 河野 吉泰, 神崎 洋光, 岩室 雅也, 川野 誠司, 河原 祥朗, 眞部 紀明, 岡田 裕之

    日本消化器病学会中国支部例会プログラム・抄録集   114回   114 - 114   2020年11月

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    記述言語:日本語   出版者・発行元:日本消化器病学会-中国支部  

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  • 咽頭癌CRT後の局所再発病変に対してサルベージESDを施行した一例

    織田 崇志, 安部 真, 濱田 健太, 榮 浩行, 河野 吉泰, 神崎 洋光, 岩室 雅也, 川野 誠司, 河原 祥朗, 岡田 裕之, 丸中 秀格

    日本消化器病学会中国支部例会プログラム・抄録集   114回   114 - 114   2020年11月

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    記述言語:日本語   出版者・発行元:日本消化器病学会-中国支部  

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  • びまん性大細胞型B細胞性リンパ腫の無治療経過観察中に胃病変の自然退縮が認められた1例

    長岡 寛和, 岩室 雅也, 田中 健大, 遠西 大輔, 榮 浩行, 安部 真, 河野 吉泰, 神崎 洋光, 川野 誠司, 河原 祥朗, 岡田 裕之

    日本消化器病学会中国支部例会プログラム・抄録集   114回   92 - 92   2020年11月

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  • 腹部内臓動脈瘤に対する血管内治療に際して発症した十二指腸潰瘍の2例

    河井 裕介, 岩室 雅也, 岡上 昇太郎, 里見 拓也, 濱田 健太, 安部 真, 榮 浩行, 河野 吉泰, 山崎 泰史, 神崎 洋光, 川野 誠司, 河原 祥朗, 岡田 裕之

    日本消化器病学会中国支部例会プログラム・抄録集   114回   73 - 73   2020年11月

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    記述言語:日本語   出版者・発行元:日本消化器病学会-中国支部  

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  • 食道病変を有するMALTリンパ腫の1例

    岡上 昇太郎, 岩室 雅也, 松岡 賢市, 田中 健大, 里見 拓也, 濱田 健太, 榮 浩行, 安部 真, 河野 吉泰, 神崎 洋光, 川野 誠司, 河原 祥朗, 岡田 裕之

    日本消化器病学会中国支部例会プログラム・抄録集   114回   71 - 71   2020年11月

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    記述言語:日本語   出版者・発行元:日本消化器病学会-中国支部  

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  • 胃癌術後11年目にKrukenberg腫瘍及び骨髄癌腫症を発症した一例

    吉田 遥, 川野 誠司, 河原 聡一郎, 岡上 昇太郎, 里見 拓也, 濱田 健太, 榮 浩行, 安部 真, 河野 吉泰, 神崎 洋光, 岩室 雅也, 河原 祥朗, 岡田 裕之

    日本消化器病学会中国支部例会プログラム・抄録集   114回   55 - 55   2020年11月

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    記述言語:日本語   出版者・発行元:日本消化器病学会-中国支部  

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  • 【高齢者早期胃癌ESDの現状と問題点】高齢者早期胃癌ESDの予後と適応 患者背景からみた高齢者早期胃癌ESDの適応評価

    宮原 孝治, 中川 昌浩, 河野 吉泰, 平田 哲, 大林 由佳, 後藤田 達洋, 高田 斎文, 森藤 由記, 平尾 謙, 國弘 真己, 水野 元夫, 岡田 裕之

    胃と腸   55 ( 12 )   1507 - 1515   2020年11月

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    記述言語:日本語   出版者・発行元:(株)医学書院  

    <文献概要>高齢者早期胃癌ESDの適否判断のため,予後や偶発症に関連する患者背景因子について検討した.対象は,80歳以上の初発早期胃癌,ESDによる内視鏡的根治度A/Bの199症例.多変量解析で,性別,performance status,PNI(prognostic nutritional index),肝硬変,推算糸球体濾過量は,ESD後全生存の関連因子であり,治療適応評価の指標となると考えられた.PNIのカットオフ値を45.5(第1四分位数)とした場合,全生存の差が有意であった.また,身体的,社会的な患者背景は偶発症にも関連しており,これら因子の十分な評価が,高齢者ESDの適否判断に重要と考える.

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  • 90歳以上の超高齢者の総胆管結石治療における5分間拡張EPBDの安全性・有用性についての検討

    植村 久尋, 高田 斎文, 平尾 謙, 中村 岳夫, 水島 秀崇, 清水 大輔, 片山 哲也, 小坂 正成, 平田 一成, 平田 哲, 後藤田 達洋, 河野 吉泰, 森藤 由記, 宮原 孝治, 國弘 真己, 中川 昌浩, 植松 周二

    Gastroenterological Endoscopy   62 ( Suppl.1 )   1247 - 1247   2020年8月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • アピキサバンが原因と考えられた薬剤性食道炎の一例

    清水 大輔, 河野 吉泰, 水島 秀崇, 中村 岳夫, 平田 哲, 後藤田 達洋, 高田 斎文, 宮原 孝治, 森藤 由記, 平尾 謙, 國弘 真己, 中川 昌浩

    日本消化器内視鏡学会中国支部例会   124回   40 - 40   2020年6月

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    記述言語:日本語   出版者・発行元:日本消化器内視鏡学会-中国支部  

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  • 急性心筋梗塞と鑑別を要した特発性食道粘膜下出血の1例

    中村 岳夫, 後藤田 達洋, 水島 秀崇, 清水 大輔, 平田 一成, 小坂 正成, 片山 哲也, 平田 哲, 河野 吉泰, 高田 斎文, 宮原 孝治, 森藤 由記, 平尾 謙, 國弘 真己, 中川 昌浩

    日本消化器内視鏡学会中国支部例会   124回   50 - 50   2020年6月

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    記述言語:日本語   出版者・発行元:日本消化器内視鏡学会-中国支部  

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  • 重度の食道狭窄をきたし外科手術を要した壊死性食道炎の一例

    三田村 祐里, 河野 吉泰, 小坂 正成, 中村 岳夫, 水島 秀崇, 清水 大輔, 平田 哲, 後藤田 達洋, 高田 斎文, 宮原 孝治, 森藤 由記, 平尾 謙, 國弘 真己, 原野 雅生, 中川 昌浩

    日本消化器内視鏡学会中国支部例会   124回   49 - 49   2020年6月

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    記述言語:日本語   出版者・発行元:日本消化器内視鏡学会-中国支部  

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  • 高齢者胃癌に対する治療戦略 高齢者早期胃癌患者に対するESDと外科切除のリスク因子

    宮原 孝治, 石田 道拡, 河野 吉泰, 久保田 哲史, 丁田 泰宏, 中川 昌浩

    日本胃癌学会総会記事   92回   229 - 229   2020年3月

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    記述言語:日本語   出版者・発行元:(一社)日本胃癌学会  

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  • H.pylori感染胃炎の内視鏡診断の進歩 H.pylori除菌後再感染は、内視鏡所見で診断できるか?

    大林 由佳, 武 進, 榮 浩行, 河野 吉泰, 三浦 公, 楠本 智章, 横田 憲治, 水野 元夫, 岡田 裕之

    日本ヘリコバクター学会学術集会プログラム・抄録集   23回   109 - 109   2017年6月

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    記述言語:日本語   出版者・発行元:(一社)日本ヘリコバクター学会  

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  • Beyondボノプラザン標準療法 当院における3次除菌療法(PPI/P-CAB+AMPC+STFX)とペニシリンアレルギーに対する治療成績の検討

    榮 浩行, 横田 憲治, 大林 由佳, 河野 吉泰, 三浦 公, 岡田 裕之

    日本ヘリコバクター学会学術集会プログラム・抄録集   23回   90 - 90   2017年6月

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    記述言語:日本語   出版者・発行元:(一社)日本ヘリコバクター学会  

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  • 切除不能進行大腸癌におけるレゴラフェニブの効果予測の検討

    三浦公, 神崎洋光, 永坂岳司, 母里淑子, 近藤喜太, 榮浩行, 河野吉泰, 杉原雄策, 田端雅弘, 岡田裕之

    日本臨床腫瘍学会学術集会(CD-ROM)   15th   2017年

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  • Current Status of Treatment Strategy for Sporadic Non-Ampullary Duodenal Adenoma: Japanese Multicenter Retrospective Observation Trial

    Hiromitsu Kanzaki, Hiroyuki Sakae, Tatsuhiro Gotoda, Yoshiyasu Kono, Kou Miura, Masaya Iwamuro, Masahide Kita, Seiji Kawano, Yoshiro Kawahara, Hiroyuki Okada

    GASTROINTESTINAL ENDOSCOPY   83 ( 5 )   AB324 - AB324   2016年5月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:MOSBY-ELSEVIER  

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  • Efficacy for the Recognition of Early Gastric Cancer Using Linked Color Imaging (LCI), the Novel Image Enhanced Endoscopy in Terms of the Value of Color Difference

    Hiromitsu Kanzaki, Yoshiro Kawahara, Hiroyuki Sakae, Tatsuhiro Gotoda, Yoshiyasu Kono, Kou Miura, Masaya Iwamuro, Masahide Kita, Seiji Kawano, Hiroyuki Okada

    GASTROENTEROLOGY   150 ( 4 )   S889 - S890   2016年4月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:W B SAUNDERS CO-ELSEVIER INC  

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  • Oxidative Stress Controlling Agents Are Effective for NSAIDs-Induced Small Intestinal Injuries

    Yoshiyasu Kono, Akinobu Takaki, Seiji Kawano, Hiroyuki Okada

    GASTROENTEROLOGY   150 ( 4 )   S693 - S693   2016年4月

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    記述言語:英語   掲載種別:研究発表ペーパー・要旨(国際会議)   出版者・発行元:W B SAUNDERS CO-ELSEVIER INC  

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  • 進行大腸癌におけるスチバーガ使用経験と有害事象対策

    三浦公, 神崎洋光, 永坂岳司, 近藤喜太, 河野吉泰, 西本仁美, 鍛治園誠, 森実真, 田端雅弘, 岡田裕之

    日本臨床腫瘍学会学術集会(CD-ROM)   13th   2015年

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  • 高齢者上部消化管出血におけるソフト凝固法の有用性の検討

    山崎 泰史, 竹中 龍太, 岡崎 倫子, 濱田 健太, 馬場 雄己, 河野 吉泰, 布上 朋和, 竹本 浩二, 平良 明彦, 柘野 浩史, 藤木 茂篤

    Gastroenterological Endoscopy   54 ( Suppl.2 )   2867 - 2867   2012年9月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • 急性胆管炎中等症例に対する市中病院における医療の現状と展望

    柘野 浩史, 馬場 雄己, 岡崎 倫子, 濱田 健太, 河野 吉泰, 布上 朋和, 山崎 泰史, 高山 裕基, 竹本 浩二, 竹中 龍太, 平良 明彦, 藤木 茂篤

    Gastroenterological Endoscopy   54 ( Suppl.1 )   1167 - 1167   2012年4月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • ステロイドミニパルス療法による反応をERCPとMRI拡散強調画像にて評価し、自己免疫性膵炎と診断しえた一例

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    Gastroenterological Endoscopy   54 ( Suppl.1 )   1255 - 1255   2012年4月

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    記述言語:日本語   出版者・発行元:(一社)日本消化器内視鏡学会  

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  • 当地域における急性胆嚢炎診療の現状

    山崎 泰史, 竹中 龍太, 岡崎 倫子, 濱田 健太, 馬場 雄己, 河野 吉泰, 布上 朋和, 高山 裕基, 竹本 浩二, 平良 明彦, 柘野 浩史, 藤木 茂篤

    日本消化器病学会雑誌   109 ( 臨増総会 )   A318 - A318   2012年3月

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    記述言語:日本語   出版者・発行元:(一財)日本消化器病学会  

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  • 膵・胆道癌の機能画像診断にPETは必要か

    柘野 浩史, 濱田 健太, 馬場 雄己, 岡崎 倫子, 山崎 泰史, 河野 吉泰, 布上 朋和, 高山 祐基, 竹本 浩二, 竹中 龍太, 平良 明彦, 藤木 茂篤

    日本消化器病学会雑誌   108 ( 臨増大会 )   A892 - A892   2011年9月

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    記述言語:日本語   出版者・発行元:(一財)日本消化器病学会  

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  • 当院における食道癌放射線化学療法の治療成績

    河野 吉泰, 平良 明彦, 岡崎 倫子, 馬場 雄己, 濱田 健太, 布上 朋和, 山崎 泰史, 竹本 浩二, 竹中 龍太, 柘野 浩史, 藤木 茂篤, 原田 聡介, 黒川 浩典, 河原 道子, 藤島 護

    日本消化器病学会雑誌   108 ( 臨増大会 )   A783 - A783   2011年9月

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    記述言語:日本語   出版者・発行元:(一財)日本消化器病学会  

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  • 【胆石症をめぐる新しいコンセンサスと展望】総胆管結石に対する長期間内視鏡的胆管ステント留置法は本当に安全か

    柘野 浩史, 濱田 健太, 馬場 雄己, 岡崎 倫子, 山崎 泰史, 河野 吉泰, 布上 朋和, 高山 裕基, 竹本 浩二, 竹中 龍太, 平良 明彦, 藤木 茂篤

    消化器内科   53 ( 2 )   202 - 205   2011年8月

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    記述言語:日本語   出版者・発行元:(有)科学評論社  

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  • 30個の病変を認めた多発直腸カルチノイドの1例

    布上 朋和, 竹本 浩二, 後藤田 達洋, 下村 泰之, 吉野 杏奈, 河野 吉泰, 井口 俊博, 関 博之, 窪田 淳一, 三好 健司, 竹中 龍太, 平良 明彦, 柘野 浩史, 藤木 茂篤

    津山中央病院医学雑誌   24 ( 1 )   47 - 52   2010年9月

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    記述言語:日本語   出版者・発行元:(一財)津山慈風会津山中央病院  

    症例は67歳、男性。残便感のため下部消化管内視鏡検査を施行したところ、直腸(Rb)に30個の径4〜10mm大の黄色調の粘膜下腫瘍を認めた。超音波内視鏡検査にて第2〜3層内に境界明瞭な低エコー腫瘤として認められ、カルチノイドと診断した。腹部造影CTでは明らかな他臓器・リンパ節転移は認めなかったため、内視鏡的粘膜切除術による切除を試みた。しかし、複数個近接している病変もあり完全切除できない可能性があるため、肛門に近い2病変のみの切除とし、残りは外科的切除を選択した。肛門縁から約3cmの範囲には内視鏡的に病変を認めず、他院にて腹腔鏡下内肛門括約筋切除術施行となった。病理組織学的所見では直腸Rbを中心に28個のカルチノイドを認め、いずれも固有筋層への浸潤は確認されなかった。しかし、直腸傍リンパ節・下腸間膜幹リンパ節・結腸傍リンパ節に転移を認めた。多発直腸カルチノイドは比較的稀であり、本邦において10個以上多発した症例の報告はこれまでに11例にすぎない。多発例はリンパ節転移の可能性が単発例より高くなることが指摘されており、治療においては注意が必要である。今回我々は30個の病変を認め、リンパ節転移を伴った多発直腸カルチノイドの1例を経験したので、若干の文献的考察を加えて報告する。(著者抄録)

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  • 当院での胃ろうトラブル2症例

    河野 吉泰, 平良 明彦, 後藤田 達洋, 布上 朋和, 井口 俊博, 関 博之, 竹本 浩二, 竹中 龍太, 柘野 浩史, 藤木 茂篤

    静脈経腸栄養   25 ( 4 )   984 - 984   2010年7月

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    記述言語:日本語   出版者・発行元:(株)ジェフコーポレーション  

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