研究者詳細 - 吉田　竜介

論文 - 吉田　竜介

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Expression of Renin-Angiotensin System Components in the Taste Organ of Mice. 査読国際誌

Noriatsu Shigemura, Shingo Takai, Fumie Hirose, Ryusuke Yoshida, Keisuke Sanematsu, Yuzo Ninomiya

Nutrients 11 ( 9 ) E2251 2019年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

The systemic renin-angiotensin system (RAS) is an important regulator of body fluid and sodium homeostasis. Angiotensin II (AngII) is a key active product of the RAS. We previously revealed that circulating AngII suppresses amiloride-sensitive salt taste responses and enhances the responses to sweet compounds via the AngII type 1 receptor (AT1) expressed in taste cells. However, the molecular mechanisms underlying the modulation of taste function by AngII remain uncharacterized. Here we examined the expression of three RAS components, namely renin, angiotensinogen, and angiotensin-converting enzyme-1 (ACE1), in mouse taste tissues. We found that all three RAS components were present in the taste buds of fungiform and circumvallate papillae and co-expressed with αENaC (epithelial sodium channel α-subunit, a salt taste receptor) or T1R3 (taste receptor type 1 member 3, a sweet taste receptor component). Water-deprived mice exhibited significantly increased levels of renin expression in taste cells (p < 0.05). These results indicate the existence of a local RAS in the taste organ and suggest that taste function may be regulated by both locally-produced and circulating AngII. Such integrated modulation of peripheral taste sensitivity by AngII may play an important role in sodium/calorie homeostasis.

DOI： 10.3390/nu11092251

PubMed

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ヒト味覚認知閾値に対する低濃度塩添加の影響査読

吉田竜介, 實松敬介, 高井信吾, 岩田周介, 重村憲徳

日本味と匂学会誌 ( 第53回大会Proceeding集 ) S35 - S38 2019年9月

摂食亢進ペプチドのラット顎下腺・舌下腺支配の副交感神経節前ニューロンに対する影響

美藤純弘, 佐藤匡, 矢島健大, 藤田雅子, 小橋基, 市川博之, 吉田竜介

日本味と匂学会誌 ( 第53回大会Proceeding集 ) S55 - S58 2019年9月

ヒト味覚認知閾値に対する低濃度塩添加の影響

吉田竜介, 實松敬介, 高井信吾, 岩田周介, 重村憲徳

日本味と匂学会誌 ( 第53回大会Proceeding集 ) S35 - S38 2019年9月

Recognizing taste: coding patterns along the neural axis in mammals. 査読

Chemical Senses 44 237 - 247 2019年5月

Effects of insulin signaling on mouse taste cell proliferation. 査読国際誌

Shingo Takai, Yu Watanabe, Keisuke Sanematsu, Ryusuke Yoshida, Robert F Margolskee, Peihua Jiang, Ikiru Atsuta, Kiyoshi Koyano, Yuzo Ninomiya, Noriatsu Shigemura

PloS one 14 ( 11 ) e0225190 2019年

記述言語：英語掲載種別：研究論文（学術雑誌）

Expression of insulin and its receptor (IR) in rodent taste cells has been proposed, but exactly which types of taste cells express IR and the function of insulin signaling in taste organ have yet to be determined. In this study, we analyzed expression of IR mRNA and protein in mouse taste bud cells in vivo and explored its function ex vivo in organoids, using RT-PCR, immunohistochemistry, and quantitative PCR. In mouse taste tissue, IR was expressed broadly in taste buds, including in type II and III taste cells. With using 3-D taste bud organoids, we found insulin in the culture medium significantly decreased the number of taste cell and mRNA expression levels of many taste cell genes, including nucleoside triphosphate diphosphohydrolase-2 (NTPDase2), Tas1R3 (T1R3), gustducin, carbonic anhydrase 4 (CA4), glucose transporter-8 (GLUT8), and sodium-glucose cotransporter-1 (SGLT1) in a concentration-dependent manner. Rapamycin, an inhibitor of mechanistic target of rapamycin (mTOR) signaling, diminished insulin's effects and increase taste cell generation. Altogether, circulating insulin might be an important regulator of taste cell growth and/or proliferation via activation of the mTOR pathway.

DOI： 10.1371/journal.pone.0225190

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Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae. 査読国際誌

Ryusuke Yoshida, Shingo Takai, Keisuke Sanematsu, Robert F Margolskee, Noriatsu Shigemura, Yuzo Ninomiya

Neuroscience 369 29 - 39 2018年1月

The Role of Cholecystokinin in Peripheral Taste Signaling in Mice 査読

Ryusuke Yoshida, Misa Shin, Keiko Yasumatsu, Shingo Takai, Mayuko Inoue, Noriatsu Shigemura, Soichi Takiguchi, Seiji Nakamura, Yuzo Ninomiya

FRONTIERS IN PHYSIOLOGY 8 2017年10月

LEPTIN SUPPRESSES SWEET TASTE RESPONSES OF ENTEROENDOCRINE STC-1 CELLS 査読

Masafumi Jyotaki, Keisuke Sanematsu, Noriatsu Shigemura, Ryusuke Yoshida, Yuzo Ninomiya

NEUROSCIENCE 332 76 - 87 2016年9月

Taste information derived from T1R-expressing taste cells in mice 査読

Ryusuke Yoshida, Yuzo Ninomiya

BIOCHEMICAL JOURNAL 473 525 - 536 2016年3月

Intracellular acidification is required for full activation of the sweet taste receptor by miraculin 査読

Keisuke Sanematsu, Masayuki Kitagawa, Ryusuke Yoshida, Satoru Nirasawa, Noriatsu Shigemura, Yuzo Ninomiya

SCIENTIFIC REPORTS 6 2016年3月

Peptide Signaling in Taste Transduction 査読

Shingo Takai, Ryusuke Yoshida, Noriatsu Shigemura, Yuzo Ninomiya

Chemosensory Transduction: The Detection of Odors, Tastes, and Other Chemostimuli 299 - 317 2016年2月

The function of glucagon-like peptide-1 in the mouse peripheral taste system 査読

Takai Shingo, Yoshida Ryusuke, Yasumatsu Keiko, Shigemura Noriatsu, Ninomiya Yuzo

JOURNAL OF ORAL BIOSCIENCES 58 ( 1 ) 10 - 15 2016年2月

Leptin Suppresses Mouse Taste Cell Responses to Sweet Compounds 査読

Ryusuke Yoshida, Kenshi Noguchi, Noriatsu Shigemura, Masafumi Jyotaki, Ichiro Takahashi, Robert F. Margolskee, Yuzo Ninomiya

DIABETES 64 ( 11 ) 3751 - 3762 2015年11月

Glucagon-like peptide-1 is specifically involved in sweet taste transmission 査読

Shingo Takai, Keiko Yasumatsu, Mayuko Inoue, Shusuke Iwata, Ryusuke Yoshida, Noriatsu Shigemura, Yuchio Yanagawa, Daniel J. Drucker, Robert F. Margolskee, Yuzo Ninomiya

FASEB JOURNAL 29 ( 6 ) 2268 - 2280 2015年6月

Modulation of sweet taste sensitivities by endogenous leptin and endocannabinoids in mice 査読

Mayu Niki, Masafumi Jyotaki, Ryusuke Yoshida, Keiko Yasumatsu, Noriatsu Shigemura, Nicholas V. DiPatrizio, Daniele Piomelli, Yuzo Ninomiya

JOURNAL OF PHYSIOLOGY-LONDON 593 ( 11 ) 2527 - 2545 2015年6月

Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice 査読

Keiko Yasumatsu, Tomohiro Manabe, Ryusuke Yoshida, Ken Iwatsuki, Hisayuki Uneyama, Ichiro Takahashi, Yuzo Ninomiya

JOURNAL OF PHYSIOLOGY-LONDON 593 ( 4 ) 1021 - 1034 2015年2月

アンギオテンシンIIによるエンドカンナビノイド受容体を介した甘味の増強

岩田周介, 吉田竜介, 重村憲徳, 二ノ宮裕三

日本味と匂学会誌 21 ( 3 ) 259 - 262 2014年12月

Taste Transductions in Taste Receptor Cells: Basic Tastes and Moreover 査読

Shusuke Iwata, Ryusuke Yoshida, Yuzo Ninomiya

CURRENT PHARMACEUTICAL DESIGN 20 ( 16 ) 2684 - 2692 2014年5月

Structure, Function, and Signaling of Taste G-Protein-Coupled Receptors 査読

Keisuke Sanematsu, Ryusuke Yoshida, Noriatsu Shigemura, Yuzo Ninomiya

CURRENT PHARMACEUTICAL BIOTECHNOLOGY 15 ( 10 ) 951 - 961 2014年

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