Updated on 2025/06/28

写真a

 
YOSHIDA Ryusuke
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Professor
Position
Professor
Homepage
https://www.okayama-u.ac.jp/user/oralphys/OralPhysiology.html
External link

Degree

  • Doctor (Science) ( 2002.3   Kobe University )

  • 理学 ( 2002.3   神戸大学大学院自然科学研究科 )

  • Master (Science) ( 1998.3   Kobe University )

  • Bachelor (Science) ( 1996.3   Kobe University )

Research Interests

  • taste

  • feeding behavior

  • obesity

  • Neuroscience

  • health science

Research Areas

  • Life Science / Oral biological science  / oral physiology

Education

  • Kobe University   大学院自然科学研究科   博士後期課程

    1999 - 2002

    　 More details

  • Kobe University   大学院自然科学研究科   博士前期課程

    1996 - 1998

    　 More details

  • Kobe University   理学部   生物学科

    1992 - 1996

    　 More details

Research History

  • Okayama University   Graduate School of Medicine , Dentistry and Pharmaceutical Sciences   Professor

    2018.10

    　 More details

  • Kyushu University   OBT研究センター

    2016.7 - 2018.9

    　 More details

  • Kyushu University   Faculty of Dental Science   Associate Professor

    2016.7 - 2018.9

    　 More details

  • Kyushu University   OBT研究センター

    2016.1 - 2016.6

    　 More details

  • Kyushu University   Faculty of Dental Science   Lecturer

    2012.4 - 2016.6

    　 More details

  • Kyushu University   Faculty of Dental Science   Assistant Professor

    2010.4 - 2012.3

    　 More details

  • Kyushu University   Faculty of Dental Science

    2009.6 - 2010.3

    　 More details

  • Kyushu University   Faculty of Dental Science

    2006.6 - 2009.5

    　 More details

  • Kyushu University   Faculty of Dental Science

    2005.12 - 2006.5

    　 More details

  • Kyushu University   Faculty of Dental Science

    2003.4 - 2005.11

    　 More details

  • 生物系特定産業技術研究推進機構   学術研究員

    2002.4 - 2003.3

    　 More details

▼display all

Professional Memberships

  • THE JAPANESE ASSOCIATION FOR THE STUDY OF TASTE AND SMELL

    　 More details

  • JAPANESE ASSOCIATION FOR ORAL BIOLOGY

    　 More details

  • Association for Chemoreception Sciences

    　 More details

  • THE JAPAN NEUROSCIENCE SOCIETY

    　 More details

  • THE PHYSIOLOGICAL SOCIETY OF JAPAN

    　 More details

 

Papers

  • Dual functions of SNAP25 in mouse taste buds Reviewed

    Kengo Horie, Kuanyu Wang, Hai Huang, Keiko Yasumatsu, Yuzo Ninomiya, Yoshihiro Mitoh, Ryusuke Yoshida

    Journal of Physiology   2025.6

    　More details

    Authorship：Last author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1113/JP288683

    researchmap

  • Taste receptor type 1 member 3 in osteoclasts regulates osteoclastogenesis via detection of glucose Reviewed

    Anna Yoshimura, Takuma Matsubara, Nao Kodama, Yoshimitsu Kakuta, Kazuma Yasuda, Ryusuke Yoshida, Osamu Kaminuma, Shuhei Hosomi, Hiroji Shinkawa, Quan Yuan, Tatsuo Kawamoto, Shoichiro Kokabu

    Journal of Biological Chemistry   108273 - 108273   2025.2

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.jbc.2025.108273

    researchmap

  • Exploring the Role of Ccn3 in Type III Cell of Mice Taste Buds Reviewed

    Journal of Neurochemistry   169   e16291   2024.12

    　More details

    Authorship：Last author,　Corresponding author  

    DOI： 10.1111/jnc.16291

    researchmap

  • Salivary buffering capacity is correlated with umami but not sour taste sensitivity in healthy adult Japanese subjects Reviewed

    Aiko Hyodo, Ayaka Mikami, Kengo Horie, Yoshihiro Mitoh, Yuzo Ninomiya, Seiji Iida, Ryusuke Yoshida

    Archives of Oral Biology   165   106013 - 106013   2024.9

    　More details

    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.archoralbio.2024.106013

    researchmap

  • The role of GABA in modulation of taste signaling within the taste bud Reviewed

    Ayaka Mikami, Hai Huang, Aiko Hyodo, Kengo Horie, Keiko Yasumatsu, Yuzo Ninomiya, Yoshihiro Mitoh, Seiji Iida, Ryusuke Yoshida

    Pflügers Archiv - European Journal of Physiology   2024.8

    　More details

    Authorship：Last author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Taste buds contain 2 types of GABA-producing cells: sour-responsive Type III cells and glial-like Type I cells. The physiological role of GABA, released by Type III cells is not fully understood. Here, we investigated the role of GABA released from Type III cells using transgenic mice lacking the expression of GAD67 in taste bud cells (Gad67-cKO mice). Immunohistochemical experiments confirmed the absence of GAD67 in Type III cells of Gad67-cKO mice. Furthermore, no difference was observed in the expression and localization of cell type markers, ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2), gustducin, and carbonic anhydrase 4 (CA4) in taste buds between wild-type (WT) and Gad67-cKO mice. Short-term lick tests demonstrated that both WT and Gad67-cKO mice exhibited normal licking behaviors to each of the five basic tastants. Gustatory nerve recordings from the chorda tympani nerve demonstrated that both WT and Gad67-cKO mice similarly responded to five basic tastants when they were applied individually. However, gustatory nerve responses to sweet–sour mixtures were significantly smaller than the sum of responses to each tastant in WT mice but not in Gad67-cKO mice. In summary, elimination of GABA signalling by sour-responsive Type III taste cells eliminates the inhibitory cell–cell interactions seen with application of sour–sweet mixtures.

    DOI： 10.1007/s00424-024-03007-x

    researchmap

    Other Link： https://link.springer.com/article/10.1007/s00424-024-03007-x/fulltext.html

  • Mechanisms and Functions of Sweet Reception in Oral and Extraoral Organs Reviewed

    Ryusuke Yoshida, Yuzo Ninomiya

    International Journal of Molecular Sciences   25 ( 13 )   7398 - 7398   2024.7

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    The oral detection of sugars relies on two types of receptor systems. The first is the G-protein-coupled receptor TAS1R2/TAS1R3. When activated, this receptor triggers a downstream signaling cascade involving gustducin, phospholipase Cβ2 (PLCβ2), and transient receptor potential channel M5 (TRPM5). The second type of receptor is the glucose transporter. When glucose enters the cell via this transporter, it is metabolized to produce ATP. This ATP inhibits the opening of KATP channels, leading to cell depolarization. Beside these receptor systems, sweet-sensitive taste cells have mechanisms to regulate their sensitivity to sweet substances based on internal and external states of the body. Sweet taste receptors are not limited to the oral cavity; they are also present in extraoral organs such as the gastrointestinal tract, pancreas, and brain. These extraoral sweet receptors are involved in various functions, including glucose absorption, insulin release, sugar preference, and food intake, contributing to the maintenance of energy homeostasis. Additionally, sweet receptors may have unique roles in certain organs like the trachea and bone. This review summarizes past and recent studies on sweet receptor systems, exploring the molecular mechanisms and physiological functions of sweet (sugar) detection in both oral and extraoral organs.

    DOI： 10.3390/ijms25137398

    researchmap

  • Distribution of alpha‐synuclein in rat salivary glands Reviewed

    Tomiko Nishitani, Yoshihiro Mitoh, Takehiro Yajima, Daisuke Tachiya, Tomohiro Hoshika, Tomohiro Fukunaga, Yoshihiro Nishitani, Ryusuke Yoshida, Itaru Mizoguchi, Hiroyuki Ichikawa, Tadasu Sato

    The Anatomical Record   2024.1

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    Abstract

    Expression of alpha‐synuclein (Syn), a presynaptic neuronal protein, was immunohistochemically examined in intact rat submandibular, sublingual, and lingual glands. The submandibular gland contained abundant periductal Syn‐immunoreactive (−ir) nerve fibers. Abundant Syn‐ir varicosities were present in acini of the sublingual and serous lingual glands. By confocal laser scanning microscopy, Syn‐ir nerve fibers around smooth muscle actin (SMA)‐ir cells alone were infrequent; however, those around aquaporin‐5 (AQP5)‐ir cells alone and both SMA‐ and AQP5‐ir cells were abundant in the sublingual and serous lingual glands. SMA‐ir cells were occasionally immunoreactive for toll‐like receptor 4, a Syn receptor. Syn‐ir nerve fibers contained tyrosine hydroxylase (TH) in the submandibular gland and choline acetyltransferase (ChAT) in all examined salivary glands. In the superior cervical (SCG), submandibular, and intralingual ganglia, sympathetic and parasympathetic neurons co‐expressed Syn with TH and ChAT, respectively. SCG neurons innervating the submandibular gland contained mostly Syn. In the thoracic spinal cord, 14.7% of ChAT‐ir preganglionic sympathetic neurons co‐expressed Syn. In the superior salivatory nucleus, preganglionic parasympathetic neurons projecting to the lingual nerve co‐expressed Syn and ChAT. The present findings indicate that released Syn acts on myoepithelial cells. Syn in pre‐ and post‐ganglionic neurons may regulate neurotransmitter release and salivary volume and composition.

    DOI： 10.1002/ar.25395

    researchmap

  • The antiarrhythmic drug flecainide enhances aversion to HCl in mice Reviewed

    Yuko Kawabata, Shingo Takai, Keisuke Sanematsu, Ryusuke Yoshida, Fuminori Kawabata, Noriatsu Shigemura

    eneuro   ENEURO.0048 - 23.2023   2023.9

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：Society for Neuroscience  

    Drug-induced taste disorders reduce quality of life, but little is known about the molecular mechanisms by which drugs induce taste disturbances. In this study, we investigated the short- and long-term effects of the antiarrhythmic drug flecainide, which is known to cause taste dysfunction. Analyses of behavioral responses (licking tests) revealed that mice given a single intraperitoneal injection of flecainide exhibited a significant reduction in preference for a sour tastant (HCl) but not for other taste solutions (NaCl, quinine, sucrose, KCl and monopotassium glutamate) when compared with controls. Mice administered a single dose of flecainide also had significantly higher taste nerve responses to HCl but not to other taste solutions. Compared with controls, mice administered flecainide once-daily for 30 days showed a reduced preference for HCl without any changes in the behavioral responses to other taste solutions. The electrophysiological experiments using HEK293T cells transiently expressing otopetrin-1 (Otop1, the mouse sour taste receptor) showed that flecainide rarely altered the responses to HCl. Taken together, our results suggest that flecainide specifically enhances the response to HCl in mice during short- and long- term administration. Although further studies will be needed to elucidate the molecular mechanisms, these findings provide new insights into the pathophysiology of drug-induced taste disorders.

    Significance Statement

    Drug-induced taste disorders reduce quality of life and can lead to nutritional disturbances. However, little is known about its molecular mechanisms. We focused on the antiarrhythmic drug flecainide inducing “unpleasant or bad taste” in human patients. Mice administered a single dose of flecainide exhibited a reduced preference for and higher taste nerve responses to HCl, sour tastants specifically. Flecainide had little change in response to HCl in HEK293T cells expressing the sour taste receptor, proton channel otopetrin-1 (Otop1). Our results suggest that flecainide enhances the responses of sour-sensing taste cells to HCl. Although further studies will be needed to elucidate the molecular mechanisms, these findings provide new insights into the pathophysiology of drug-induced taste disorders.

    DOI： 10.1523/eneuro.0048-23.2023

    researchmap

  • Sensory Systems for Sugar-Induced Cephalic Phase Insulin Release Invited Reviewed

    Ryusuke Yoshida

    Current Oral Health Reports   2023.8

    　More details

    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Purpose of Review

    This review aims to discuss and summarize the peripheral sensory mechanisms involved in the induction of the early phase of insulin release, known as cephalic phase insulin release (CPIR), triggered by stimuli related to food, particularly sugars.

    Recent Findings

    At least, two distinct systems on the tongue are responsible for detecting oral sugars. The first system involves the G-protein-coupled receptor Tas1r2/Tas1r3, which can detect not only sugars but also artificial sweeteners and sweet proteins. The second system relies on glucose transporters, specifically recognize and transport monosaccharides. The Tas1r2/Tas1r3 receptor utilizes a signal transduction pathway involving gustducin, phospholipase β2, and transient receptor potential channel M5 to depolarize taste cells. On the other hand, glucose transporters facilitate the transport of monosaccharides into cells, where their degradation produces ATP. This ATP inhibits the metabolic sensor KATP channel, ultimately leading to cell depolarization. Recent studies in mice have demonstrated that glucose transporters and KATP channels, rather than the Tas1r2/Tas1r3 receptor, are essential for the induction of CPIR.

    Summary

    The detection of sugars in the oral cavity relies on two essential mechanisms: the Tas1r2/Tas1r3 receptor and glucose transporters. Notably, oral glucose transporters are likely to play a significant role in the induction of sugar-induced CPIR. As a result, these two sugar detection systems may have distinct roles in maintaining energy homeostasis within the body.

    DOI： 10.1007/s40496-023-00347-y

    researchmap

    Other Link： https://link.springer.com/article/10.1007/s40496-023-00347-y/fulltext.html

  • Sugar signals from oral glucose transporters elicit cephalic-phase insulin release in mice Reviewed

    Mitsuhito Takamori, Yoshihiro Mitoh, Kengo Horie, Masahiko Egusa, Takuya Miyawaki, Ryusuke Yoshida

    The Journal of Physiological Sciences   73 ( 1 )   2023.7

    　More details

    Authorship：Last author,　Corresponding author   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Cephalic-phase insulin release (CPIR) occurs before blood glucose increases after a meal. Although glucose is the most plausible cue to induce CPIR, peripheral sensory systems involved are not fully elucidated. We therefore examined roles of sweet sensing by a T1R3-dependent taste receptor and sugar sensing by oral glucose transporters in the oropharyngeal region in inducing CPIR. Spontaneous oral ingestion of glucose significantly increased plasma insulin 5 min later in wild-type (C57BL/6) and T1R3-knockout mice, but intragastric infusion did not. Oral treatment of glucose transporter inhibitors phlorizin and phloretin significantly reduced CPIR after spontaneous oral ingestion. In addition, a rapid increase in plasma insulin was significantly smaller in WT mice with spontaneous oral ingestion of nonmetabolizable glucose analog than in WT mice with spontaneous oral ingestion of glucose. Taken together, the T1R3-dependent receptor is not required for CPIR, but oral glucose transporters greatly contribute to induction of CPIR by sugars.

    DOI： 10.1186/s12576-023-00875-3

    researchmap

    Other Link： https://link.springer.com/article/10.1186/s12576-023-00875-3/fulltext.html

  • Adrenomedullin Enhances Mouse Gustatory Nerve Responses to Sugars via T1R-Independent Sweet Taste Pathway Reviewed

    Shusuke Iwata, Ryusuke Yoshida, Shingo Takai, Keisuke Sanematsu, Noriatsu Shigemura, Yuzo Ninomiya

    Nutrients   15 ( 13 )   2941 - 2941   2023.6

    　More details

    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    On the tongue, the T1R-independent pathway (comprising glucose transporters, including sodium–glucose cotransporter (SGLT1) and the KATP channel) detects only sugars, whereas the T1R-dependent (T1R2/T1R3) pathway can broadly sense various sweeteners. Cephalic-phase insulin release, a rapid release of insulin induced by sensory signals in the head after food-related stimuli, reportedly depends on the T1R-independent pathway, and the competitive sweet taste modulators leptin and endocannabinoids may function on these two different sweet taste pathways independently, suggesting independent roles of two oral sugar-detecting pathways in food intake. Here, we examined the effect of adrenomedullin (ADM), a multifunctional regulatory peptide, on sugar sensing in mice since it affects the expression of SGLT1 in rat enterocytes. We found that ADM receptor components were expressed in T1R3-positive taste cells. Analyses of chorda tympani (CT) nerve responses revealed that ADM enhanced responses to sugars but not to artificial sweeteners and other tastants. Moreover, ADM increased the apical uptake of a fluorescent D-glucose derivative into taste cells and SGLT1 mRNA expression in taste buds. These results suggest that the T1R-independent sweet taste pathway in mouse taste cells is a peripheral target of ADM, and the specific enhancement of gustatory nerve responses to sugars by ADM may contribute to caloric sensing and food intake.

    DOI： 10.3390/nu15132941

    researchmap

  • Taste Responses and Ingestive Behaviors to Ingredients of Fermented Milk in Mice Reviewed

    Yamase Yuko, Huang Hai, Mitoh Yoshihiro, Egusa Masahiko, Miyawaki Takuya, Yoshida Ryusuke

    Foods   12 ( 6 )   1150   2023.3

    　More details

    Authorship：Last author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/foods12061150

    researchmap

  • Effect of continuous sweet gustatory stimulation on salivary flow rate over time Reviewed International journal

    Ranko Yamada, Yuki Tanaka, Hikaru Sugimoto, Naoki Kodama, Ryusuke Yoshida, Shogo Minagi

    Archives of Oral Biology   146   105590 - 105590   2023.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    OBJECTIVE: This study aimed to determine changes in saliva secretion and subjective taste intensity during a sustained period with continuous gustatory stimulation. DESIGN: Twenty-two healthy adults participated in this study. The selected taste solutions were aspartame, sucralose, and acesulfame potassium, which are nonnutritive sweeteners. The concentrations of sucralose1 and acesulfame potassium were set to show the same sweetness intensity as aspartame. Sucralose2 was twice the concentration of sucralose1. The solution was continuously fed into the oral cavity at a flow rate of 0.04 mL / min through a neck-worn precise infusion system. The salivary flow rate (g/min) after 10 min of intraoral water supply from the device was used as the baseline. Salivary flow rate, subjective taste intensity evaluated by the visual analog scale (VAS), and salivary flow rate relative to the baseline were recorded at 10, 30, 60, and 120 min after the start of the test. RESULTS: In the aspartame, sucralose1, and sucralose2 groups, the salivary flow rate increased significantly from 10 min to 120 min after the start of the test when compared to the rate at baseline (p < 0.05). The relative salivary flow rate increased and the VAS value decreased significantly over time and were affected by the time factor (p < 0.001, p = 0.013, respectively) but not by the sweetener-group factor and the interaction effects. CONCLUSIONS: Continuous gustatory stimulation may maintain increased salivary production for a sustained period.

    DOI： 10.1016/j.archoralbio.2022.105590

    PubMed

    researchmap

  • Phosphatidylinositol‐3 kinase mediates the sweet suppressive effect of leptin in mouse taste cells Reviewed

    Ryusuke Yoshida, Robert F. Margolskee, Yuzo Ninomiya

    Journal of Neurochemistry   2021.6

    　More details

    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    researchmap

  • The sweet taste receptor, glucose transporters, and the ATP-sensitive K+ (KATP) channel: sugar sensing for the regulation of energy homeostasis Reviewed

    Ryusuke Yoshida, Keiko Yasumatsu, Yuzo Ninomiya

    Current Opinion in Physiology   20   57 - 63   2021.4

    　More details

    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    DOI： 10.1016/j.cophys.2021.01.009

    researchmap

  • The sweet taste receptor, glucose transporters, andthe ATP-sensitive K+(KATP) channel: sugar sensingfor the regulation of energy homeostasis Invited Reviewed

    20   57 - 63   2021.1

    　More details

    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

  • Orexin A and B in the rat superior salivatory nucleus Reviewed International journal

    Tadasu Sato, Takehiro Yajima, Masako Fujita, Motoi Kobashi, Hiroyuki Ichikawa, Ryusuke Yoshida, Yoshihiro Mitoh

    Autonomic Neuroscience   228   102712 - 102712   2020.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    Orexin (OX), which regulates sleep and wakefulness and feeding behaviors has 2 isoforms, orexin-A and -B (OXA and OXB). In this study, the distribution of OXA and OXB was examined in the rat superior salivatory nucleus (SSN) using retrograde tracing and immunohistochemical and methods. OXA- and OXB-immunoreactive (-ir) nerve fibers were seen throughout the SSN. These nerve fibers surrounded SSN neurons retrogradely labeled with Fast blue (FB) from the corda-lingual nerve. FB-positive neurons had pericellular OXA- (47.5%) and OXB-ir (49.0%) nerve fibers. Immunohistochemistry for OX receptors also demonstrated the presence of OX1R and OX2R in FB-positive SSN neurons. The majority of FB-positive SSN neurons contained OX1R- (69.7%) or OX2R-immunoreactivity (57.8%). These neurons had small and medium-sized cell bodies. In addition, half of FB-positive SSN neurons which were immunoreactive for OX1R (47.0%) and OX2R (52.2%) had pericellular OXA- and OXB-ir nerve fibers, respectively. Co-expression of OX1R- and OX2R was common in FB-positive SSN neurons. The present study suggests a possibility that OXs regulate the activity of SSN neurons through OX receptors.

    DOI： 10.1016/j.autneu.2020.102712

    PubMed

    researchmap

  • Sodium‐glucose cotransporter 1 as a sugar taste sensor in mouse tongue Reviewed International journal

    Keiko Yasumatsu, Tadahiro Ohkuri, Ryusuke Yoshida, Shusuke Iwata, Robert F. Margolskee, Yuzo Ninomiya

    Acta Physiologica   230 ( 4 )   e13529   2020.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Wiley  

    AIM: We investigated potential neuron types that code sugar information and how sodium-glucose cotransporters (SGLTs) and T1Rs are involved. METHODS: Whole-nerve recordings in the chorda tympani (CT) and the glossopharyngeal (GL) nerves and single-fibre recordings in the CT were performed in T1R3-KO and wild-type (WT) mice. Behavioural response measurements were conducted in T1R3-KO mice using phlorizin (Phl), a competitive inhibitor of SGLTs. RESULTS: Results indicated that significant enhancement occurred in responses to sucrose and glucose (Glc) by adding 10 mmol/L NaCl but not in responses to KCl, monopotassium glutamate, citric acid, quinine sulphate, SC45647(SC) or polycose in both CT and GL nerves. These enhancements were abolished by lingual application of Phl. In single-fibre recording, fibres showing maximal response to sucrose could be classified according to responses to SC and Glc with or without 10 mmol/L NaCl in the CT of WT mice, namely, Phl-insensitive type, Phl-sensitive Glc-type and Mixed (Glc and SC responding)-type fibres. In T1R3-KO mice, Phl-insensitive-type fibres disappeared. Results from behavioural experiments showed that the number of licks and amount of intake for Glc with or without 10 mmol/L NaCl were significantly suppressed by Phl. CONCLUSION: We found evidence for the contribution of SGLTs in sugar sensing in taste cells of mouse tongue. Moreover, we found T1R-dependent (Phl-insensitive) type, Glc-type and Mixed (SGLTs and T1Rs)-type fibres. SGLT1 may be involved in the latter two types and may play important roles in the glucose-specific cephalic phase of digestion and palatable food intake.

    DOI： 10.1111/apha.13529

    PubMed

    researchmap

    Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/apha.13529

  • The Effects of Mutual Interaction of Orexin-A and Glucagon-Like Peptide-1 on Reflex Swallowing Induced by SLN Afferents in Rats Reviewed

    Motoi Kobashi, Yuichi Shimatani, Masako Fujita, Yoshihiro Mitoh, Ryusuke Yoshida, Ryuji Matsuo

    International Journal of Molecular Sciences   21 ( 12 )   4422 - 4422   2020.6

    　More details

    Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    DOI： 10.3390/ijms21124422

    Scopus

    PubMed

    researchmap

  • Effects of bitter receptor antagonists on behavioral lick responses of mice Reviewed International journal

    Michimasa Masamoto, Yoshihiro Mitoh, Motoi Kobashi, Noriatsu Shigemura, Ryusuke Yoshida

    Neuroscience Letters   730   135041 - 135041   2020.6

    　More details

    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    Bitter taste receptors TAS2Rs detect noxious compounds in the oral cavity. Recent heterologous expression studies reported that some compounds function as antagonists for human TAS2Rs. For examples, amino acid derivatives such as γ-aminobutyric acid (GABA) and Nα,Nα-bis(carboxymethyl)-L-Lysine (BCML) blocked responses to quinine mediated by human TAS2R4. Probenecid inhibited responses to phenylthiocarbamide mediated by human TAS2R38. In this study, we investigated the effects of these human bitter receptor antagonists on behavioral lick responses of mice to elucidate whether these compounds also function as bitter taste blockers. In short-term (10 s) lick tests, concentration-dependent lick responses to bitter compounds (quinine-HCl, denatonium and phenylthiourea) were not affected by the addition of GABA or BCML. Probenecid reduced aversive lick responses to denatonium and phenylthiourea but not to quinine-HCl. In addition, taste cell responses to phenylthiourea were inhibited by probenecid. These results suggest some bitter antagonists of human TAS2Rs can work for bitter sense of mouse.

    DOI： 10.1016/j.neulet.2020.135041

    PubMed

    researchmap

  • Expression of Renin-Angiotensin System Components in the Taste Organ of Mice. Reviewed International journal

    Noriatsu Shigemura, Shingo Takai, Fumie Hirose, Ryusuke Yoshida, Keisuke Sanematsu, Yuzo Ninomiya

    Nutrients   11 ( 9 )   E2251   2019.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    The systemic renin-angiotensin system (RAS) is an important regulator of body fluid and sodium homeostasis. Angiotensin II (AngII) is a key active product of the RAS. We previously revealed that circulating AngII suppresses amiloride-sensitive salt taste responses and enhances the responses to sweet compounds via the AngII type 1 receptor (AT1) expressed in taste cells. However, the molecular mechanisms underlying the modulation of taste function by AngII remain uncharacterized. Here we examined the expression of three RAS components, namely renin, angiotensinogen, and angiotensin-converting enzyme-1 (ACE1), in mouse taste tissues. We found that all three RAS components were present in the taste buds of fungiform and circumvallate papillae and co-expressed with αENaC (epithelial sodium channel α-subunit, a salt taste receptor) or T1R3 (taste receptor type 1 member 3, a sweet taste receptor component). Water-deprived mice exhibited significantly increased levels of renin expression in taste cells (p < 0.05). These results indicate the existence of a local RAS in the taste organ and suggest that taste function may be regulated by both locally-produced and circulating AngII. Such integrated modulation of peripheral taste sensitivity by AngII may play an important role in sodium/calorie homeostasis.

    DOI： 10.3390/nu11092251

    PubMed

    researchmap

  • ヒト味覚認知閾値に対する低濃度塩添加の影響 Reviewed

    吉田 竜介, 實松 敬介, 高井 信吾, 岩田 周介, 重村 憲徳

    日本味と匂学会誌   ( 第53回大会Proceeding集 )   S35 - S38   2019.9

    　More details

    Authorship：Lead author,　Corresponding author   Language：Japanese   Publisher：日本味と匂学会  

    researchmap

  • 摂食亢進ペプチドのラット顎下腺・舌下腺支配の副交感神経節前ニューロンに対する影響

    美藤 純弘, 佐藤 匡, 矢島 健大, 藤田 雅子, 小橋 基, 市川 博之, 吉田 竜介

    日本味と匂学会誌   ( 第53回大会Proceeding集 )   S55 - S58   2019.9

    　More details

    Language：Japanese   Publisher：日本味と匂学会  

    researchmap

  • ヒト味覚認知閾値に対する低濃度塩添加の影響

    吉田 竜介, 實松 敬介, 高井 信吾, 岩田 周介, 重村 憲徳

    日本味と匂学会誌   ( 第53回大会Proceeding集 )   S35 - S38   2019.9

    　More details

    Language：Japanese   Publisher：日本味と匂学会  

    researchmap

  • Recognizing taste: coding patterns along the neural axis in mammals. Reviewed

    Kathrin Ohla, Ryusuke Yoshida, Stephen D Roper, Patricia M Di Lorenzo, Jonathan D Victor, John D Boughter, Max Fletcher, Donald B Katz, Nirupa Chaudhari

    Chemical Senses   44   237 - 247   2019.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/chemse/bjz013

    researchmap

  • Effects of insulin signaling on mouse taste cell proliferation. Reviewed International journal

    Shingo Takai, Yu Watanabe, Keisuke Sanematsu, Ryusuke Yoshida, Robert F Margolskee, Peihua Jiang, Ikiru Atsuta, Kiyoshi Koyano, Yuzo Ninomiya, Noriatsu Shigemura

    PloS one   14 ( 11 )   e0225190   2019

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Expression of insulin and its receptor (IR) in rodent taste cells has been proposed, but exactly which types of taste cells express IR and the function of insulin signaling in taste organ have yet to be determined. In this study, we analyzed expression of IR mRNA and protein in mouse taste bud cells in vivo and explored its function ex vivo in organoids, using RT-PCR, immunohistochemistry, and quantitative PCR. In mouse taste tissue, IR was expressed broadly in taste buds, including in type II and III taste cells. With using 3-D taste bud organoids, we found insulin in the culture medium significantly decreased the number of taste cell and mRNA expression levels of many taste cell genes, including nucleoside triphosphate diphosphohydrolase-2 (NTPDase2), Tas1R3 (T1R3), gustducin, carbonic anhydrase 4 (CA4), glucose transporter-8 (GLUT8), and sodium-glucose cotransporter-1 (SGLT1) in a concentration-dependent manner. Rapamycin, an inhibitor of mechanistic target of rapamycin (mTOR) signaling, diminished insulin's effects and increase taste cell generation. Altogether, circulating insulin might be an important regulator of taste cell growth and/or proliferation via activation of the mTOR pathway.

    DOI： 10.1371/journal.pone.0225190

    PubMed

    researchmap

  • Bitter Taste Responses of Gustducin-positive Taste Cells in Mouse Fungiform and Circumvallate Papillae. Reviewed International journal

    Ryusuke Yoshida, Shingo Takai, Keisuke Sanematsu, Robert F Margolskee, Noriatsu Shigemura, Yuzo Ninomiya

    Neuroscience   369   29 - 39   2018.1

    　More details

    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.neuroscience.2017.10.047

    Web of Science

    PubMed

    researchmap

  • The Role of Cholecystokinin in Peripheral Taste Signaling in Mice Reviewed

    Ryusuke Yoshida, Misa Shin, Keiko Yasumatsu, Shingo Takai, Mayuko Inoue, Noriatsu Shigemura, Soichi Takiguchi, Seiji Nakamura, Yuzo Ninomiya

    FRONTIERS IN PHYSIOLOGY   8   2017.10

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fphys.2017.00866

    Web of Science

    researchmap

  • LEPTIN SUPPRESSES SWEET TASTE RESPONSES OF ENTEROENDOCRINE STC-1 CELLS Reviewed

    Masafumi Jyotaki, Keisuke Sanematsu, Noriatsu Shigemura, Ryusuke Yoshida, Yuzo Ninomiya

    NEUROSCIENCE   332   76 - 87   2016.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.neuroscience.2016.06.036

    Web of Science

    researchmap

  • Taste information derived from T1R-expressing taste cells in mice Reviewed

    Ryusuke Yoshida, Yuzo Ninomiya

    BIOCHEMICAL JOURNAL   473   525 - 536   2016.3

    　More details

    Authorship：Lead author   Language：English  

    DOI： 10.1042/BJ20151015

    Web of Science

    researchmap

  • Intracellular acidification is required for full activation of the sweet taste receptor by miraculin Reviewed

    Keisuke Sanematsu, Masayuki Kitagawa, Ryusuke Yoshida, Satoru Nirasawa, Noriatsu Shigemura, Yuzo Ninomiya

    SCIENTIFIC REPORTS   6   2016.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/srep22807

    Web of Science

    researchmap

  • Peptide Signaling in Taste Transduction Reviewed

    Shingo Takai, Ryusuke Yoshida, Noriatsu Shigemura, Yuzo Ninomiya

    Chemosensory Transduction: The Detection of Odors, Tastes, and Other Chemostimuli   299 - 317   2016.2

    　More details

    Publishing type：Part of collection (book)  

    DOI： 10.1016/B978-0-12-801694-7.00017-2

    Scopus

    researchmap

  • The function of glucagon-like peptide-1 in the mouse peripheral taste system Reviewed

    Takai Shingo, Yoshida Ryusuke, Yasumatsu Keiko, Shigemura Noriatsu, Ninomiya Yuzo

    JOURNAL OF ORAL BIOSCIENCES   58 ( 1 )   10 - 15   2016.2

    　More details

  • Leptin Suppresses Mouse Taste Cell Responses to Sweet Compounds Reviewed

    Ryusuke Yoshida, Kenshi Noguchi, Noriatsu Shigemura, Masafumi Jyotaki, Ichiro Takahashi, Robert F. Margolskee, Yuzo Ninomiya

    DIABETES   64 ( 11 )   3751 - 3762   2015.11

    　More details

    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2337/db14-1462

    Web of Science

    researchmap

  • Glucagon-like peptide-1 is specifically involved in sweet taste transmission Reviewed

    Shingo Takai, Keiko Yasumatsu, Mayuko Inoue, Shusuke Iwata, Ryusuke Yoshida, Noriatsu Shigemura, Yuchio Yanagawa, Daniel J. Drucker, Robert F. Margolskee, Yuzo Ninomiya

    FASEB JOURNAL   29 ( 6 )   2268 - 2280   2015.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1096/fj.14-265355

    Web of Science

    researchmap

  • Modulation of sweet taste sensitivities by endogenous leptin and endocannabinoids in mice Reviewed

    Mayu Niki, Masafumi Jyotaki, Ryusuke Yoshida, Keiko Yasumatsu, Noriatsu Shigemura, Nicholas V. DiPatrizio, Daniele Piomelli, Yuzo Ninomiya

    JOURNAL OF PHYSIOLOGY-LONDON   593 ( 11 )   2527 - 2545   2015.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1113/JP270295

    Web of Science

    researchmap

  • Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice Reviewed

    Keiko Yasumatsu, Tomohiro Manabe, Ryusuke Yoshida, Ken Iwatsuki, Hisayuki Uneyama, Ichiro Takahashi, Yuzo Ninomiya

    JOURNAL OF PHYSIOLOGY-LONDON   593 ( 4 )   1021 - 1034   2015.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1113/jphysiol.2014.284703

    Web of Science

    researchmap

  • アンギオテンシンIIによるエンドカンナビノイド受容体を介した甘味の増強

    岩田 周介, 吉田 竜介, 重村 憲徳, 二ノ宮 裕三

    日本味と匂学会誌   21 ( 3 )   259 - 262   2014.12

    　More details

  • Taste Transductions in Taste Receptor Cells: Basic Tastes and Moreover Reviewed

    Shusuke Iwata, Ryusuke Yoshida, Yuzo Ninomiya

    CURRENT PHARMACEUTICAL DESIGN   20 ( 16 )   2684 - 2692   2014.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2174/13816128113199990575

    Web of Science

    researchmap

  • Structure, Function, and Signaling of Taste G-Protein-Coupled Receptors Reviewed

    Keisuke Sanematsu, Ryusuke Yoshida, Noriatsu Shigemura, Yuzo Ninomiya

    CURRENT PHARMACEUTICAL BIOTECHNOLOGY   15 ( 10 )   951 - 961   2014

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2174/1389201015666140922105911

    Web of Science

    researchmap

  • Expression and function of GLP-1 receptor on gustatory nerve neurons. Reviewed

    Shingo Takai, Keiko Yasumatsu, Ryusuke Yoshida, Noriatsu Shigemura, Yuzo Ninomiya

    The Japanese Journal of Taste and Smell Research 2014 No.21-3   21 ( 3 )   253 - 256   2014

    　More details

    Language：Japanese   Publishing type：Research paper (scientific journal)   Publisher：The Japanese Association for the Study of Taste and Smell  

    CiNii Article

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2016009974

  • Angiotensin II Modulates Salty and Sweet Taste Sensitivities Reviewed

    Noriatsu Shigemura, Shusuke Iwata, Keiko Yasumatsu, Tadahiro Ohkuri, Nao Horio, Keisuke Sanematsu, Ryusuke Yoshida, Robert F. Margolskee, Yuzo Ninomiya

    JOURNAL OF NEUROSCIENCE   33 ( 15 )   6267 - 6277   2013.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1523/JNEUROSCI.5599-12.2013

    Web of Science

    researchmap

  • Taste responses in mice lacking taste receptor subunit T1R1 Reviewed

    Yoko Kusuhara, Ryusuke Yoshida, Tadahiro Ohkuri, Keiko Yasumatsu, Anja Voigt, Sandra Huebner, Katsumasa Maeda, Ulrich Boehm, Wolfgang Meyerhof, Yuzo Ninomiya

    JOURNAL OF PHYSIOLOGY-LONDON   591 ( 7 )   1967 - 1985   2013.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1113/jphysiol.2012.236604

    Web of Science

    researchmap

  • Modulation of sweet responses of taste receptor cells Reviewed

    Ryusuke Yoshida, Mayu Niki, Masafumi Jyotaki, Keisuke Sanematsu, Noriatsu Shigemura, Yuzo Ninomiya

    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY   24 ( 3 )   226 - 231   2013.3

    　More details

  • Umami taste in mice uses multiple receptors and transduction pathways Reviewed

    Keiko Yasumatsu, Yoko Ogiwara, Shingo Takai, Ryusuke Yoshida, Ken Iwatsuki, Kunio Torii, Robert F. Margolskee, Yuzo Ninomiya

    JOURNAL OF PHYSIOLOGY-LONDON   590 ( 5 )   1155 - 1170   2012.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1113/jphysiol.2011.211920

    Web of Science

    researchmap

  • Responses to Apical and Basolateral Application of Glutamate in Mouse Fungiform Taste Cells with Action Potentials Reviewed

    Mayu Niki, Shingo Takai, Yoko Kusuhara, Yuzo Ninomiya, Ryusuke Yoshida

    CELLULAR AND MOLECULAR NEUROBIOLOGY   31 ( 7 )   1033 - 1040   2011.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10571-011-9702-5

    Web of Science

    researchmap

  • Sour Taste Responses in Mice Lacking PKD Channels Reviewed

    Nao Horio, Ryusuke Yoshida, Keiko Yasumatsu, Yuchio Yanagawa, Yoshiro Ishimaru, Hiroaki Matsunami, Yuzo Ninomiya

    PLOS ONE   6 ( 5 )   2011.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0020007

    Web of Science

    researchmap

  • Gustatory Signaling in the Periphery: Detection, Transmission, and Modulation of Taste Information Reviewed

    Mayu Niki, Ryusuke Yoshida, Shingo Takai, Yuzo Ninomiya

    BIOLOGICAL & PHARMACEUTICAL BULLETIN   33 ( 11 )   1772 - 1777   2010.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1248/bpb.33.1772

    Web of Science

    researchmap

  • Action Potential-Enhanced ATP Release From Taste Cells Through Hemichannels Reviewed

    Yoshihiro Murata, Toshiaki Yasuo, Ryusuke Yoshida, Kunihiko Obata, Yuchio Yanagawa, Robert F. Margolskee, Yuzo Ninomiya

    JOURNAL OF NEUROPHYSIOLOGY   104 ( 2 )   896 - 901   2010.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1152/jn.00414.2010

    Web of Science

    researchmap

  • 内因性カンナビノイドはマウスの甘味応答を増大させる(Endocannabinoids enhance sweet taste sensitivities in mice) Reviewed

    吉田 竜介, 大栗 弾宏, 上瀧 将史, 安尾 敏明, 堀尾 奈央, 安松 啓子, 實松 敬介, 重村 憲徳, 山本 経之, Margolskee Robert F., 二ノ宮 裕三

    神経化学   49 ( 2-3 )   730 - 730   2010.8

    　More details

    Language：English   Publisher：日本神経化学会  

    researchmap

  • Taste Preference for Fatty Acids Is Mediated by GPR40 and GPR120 Reviewed

    Cristina Cartoni, Keiko Yasumatsu, Tadahiro Ohkuri, Noriatsu Shigemura, Ryusuke Yoshida, Nicolas Godinot, Johannes le Coutre, Yuzo Ninomiya, Sami Damak

    JOURNAL OF NEUROSCIENCE   30 ( 25 )   8376 - 8382   2010.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1523/JNEUROSCI.0496-10.2010

    Web of Science

    researchmap

  • Endocannabinoids selectively enhance sweet taste Reviewed

    Ryusuke Yoshida, Tadahiro Ohkuri, Masafumi Jyotaki, Toshiaki Yasuo, Nao Horio, Keiko Yasumatsu, Keisuke Sanematsu, Noriatsu Shigemura, Tsuneyuki Yamamoto, Robert F. Margolskee, Yuzo Ninomiya

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   107 ( 2 )   935 - 939   2010.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1073/pnas.0912048107

    Web of Science

    researchmap

  • New Frontiers in Gut Nutrient Sensor Research: Nutrient Sensors in the Gastrointestinal Tract: Modulation of Sweet Taste Sensitivity by Leptin Reviewed

    Nao Horio, Masafumi Jyotaki, Ryusuke Yoshida, Keisuke Sanematsu, Noriatsu Shigemura, Yuzo Ninomiya

    JOURNAL OF PHARMACOLOGICAL SCIENCES   112 ( 1 )   8 - 12   2010.1

    　More details

  • Reception and transmission of taste information in type ii and type ie taste bud cells

    Ryusuke Yoshida, Mayu Niki, Yoshihiro Murata, Noriatsu Shigemura, Yuzo Ninomiya

    Journal of Oral Biosciences   52 ( 4 )   358 - 364   2010

    　More details

    Language：English   Publisher：Japanese Association for Oral Biology  

    DOI： 10.2330/joralbiosci.52.358

    Scopus

    researchmap

  • Reciprocal modulation of sweet taste by leptin and endocannabinoids Reviewed

    Mayu Niki, Masafumi Jyotaki, Ryusuke Yoshida, Yuzo Ninomiya

    Results and Problems in Cell Differentiation   52   101 - 114   2010

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/978-3-642-14426-4_9

    Scopus

    PubMed

    researchmap

  • NEW INSIGHTS INTO THE SIGNAL TRANSMISSION FROM TASTE CELLS TO GUSTATORY NERVE FIBERS Reviewed

    Ryusuke Yoshida, Yuzo Ninomiya

    INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 279   279   101 - 134   2010

    　More details

    Language：English   Publishing type：Part of collection (book)  

    DOI： 10.1016/S1937-6448(10)79004-3

    Web of Science

    researchmap

  • Discrimination of taste qualities among mouse fungiform taste bud cells Reviewed

    Ryusuke Yoshida, Aya Miyauchi, Toshiaki Yasuo, Masafumi Jyotaki, Yoshihiro Murata, Keiko Yasumatsu, Noriatsu Shigemura, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Robert F. Margolskee, Yuzo Ninomiya

    JOURNAL OF PHYSIOLOGY-LONDON   587 ( 18 )   4425 - 4439   2009.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1113/jphysiol.2009.175075

    Web of Science

    researchmap

  • Multiple receptors underlie glutamate taste responses in mice Reviewed

    Keiko Yasumatsu, Nao Horio, Yoshihiro Murata, Shinya Shirosaki, Tadahiro Ohkuri, Ryusuke Yoshida, Yuzo Ninomiya

    AMERICAN JOURNAL OF CLINICAL NUTRITION   90 ( 3 )   747S - 752S   2009.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3945/ajcn.2009.27462J

    Web of Science

    researchmap

  • Variation in umami perception and in candidate genes for the umami receptor in mice and humans Reviewed

    Noriatsu Shigemura, Shinya Shirosaki, Tadahiro Ohkuri, Keisuke Sanematsu, A. A. Shahidul Islam, Yoko Ogiwara, Misako Kawai, Ryusuke Yoshida, Yuzo Ninomiya

    AMERICAN JOURNAL OF CLINICAL NUTRITION   90 ( 3 )   764S - 769S   2009.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3945/ajcn.2009.27462M

    Web of Science

    researchmap

  • Genetic and Molecular Basis of Individual Differences in Human Umami Taste Perception Reviewed

    Noriatsu Shigemura, Shinya Shirosaki, Keisuke Sanematsu, Ryusuke Yoshida, Yuzo Ninomiya

    PLOS ONE   4 ( 8 )   2009.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0006717

    Web of Science

    researchmap

  • NaCl RESPONSIVE TASTE CELLS IN THE MOUSE FUNGIFORM TASTE BUDS Reviewed

    R. Yoshida, N. Horio, Y. Murata, K. Yasumatsu, N. Shigemura, Y. Ninomiya

    NEUROSCIENCE   159 ( 2 )   795 - 803   2009.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.neuroscience.2008.12.052

    Web of Science

    PubMed

    researchmap

  • Modulation and Transmission of Sweet Taste Information for Energy Homeostasis Reviewed

    Keisuke Sanematsu, Nao Horio, Yoshihiro Murata, Ryusuke Yoshida, Tadahiro Ohkuri, Noriatsu Shigemura, Yuzo Ninomiya

    INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE   1170   102 - 106   2009

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1749-6632.2009.03893.x

    Web of Science

    researchmap

  • Multiple Receptor Systems for Umami Taste in Mice Reviewed

    Ryusuke Yoshida, Keiko Yasumatsu, Shinya Shirosaki, Masashi Jyotaki, Nao Horio, Yoshihiro Murata, Noriatsu Shigemura, Kiyohito Nakashima, Yuzo Ninomiya

    INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE   1170   51 - 54   2009

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1749-6632.2009.03902.x

    Web of Science

    researchmap

  • The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions Reviewed

    Karel Talavera, Keiko Yasumatsu, Ryusuke Yoshida, Robert F. Margolskee, Thomas Voets, Yuzo Ninomiya, Bernd Nilius

    FASEB JOURNAL   22 ( 5 )   1343 - 1355   2008.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1096/fj.07-9591com

    Web of Science

    researchmap

  • Amiloride-sensitive NaCl taste responses are associated with genetic variation of ENaC alpha-subunit in mice Reviewed

    Noriatsu Shigemura, Tadahiro Ohkuri, Chiharu Sadamitsu, Keiko Yasumatsu, Ryusuke Yoshida, Gary K. Beauchamp, Alexander A. Bachmanov, Yuzo Ninomiya

    AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY   294 ( 1 )   R66 - R75   2008.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1152/ajpregu.00420.2007

    Web of Science

    researchmap

  • 1P-237 Reception and transduction systems for umami taste in mice(The 46th Annual Meeting of the Biophysical Society of Japan)

    Yoshida Ryusuke, Yasumatsu Keiko, Shirosaki Shinya, Kawato Yuriko, Murata Yoshihiro, Shigemura Noriatsu, Nakashima Kiyohito, Margolskee Robert F., Ninomiya Yuzo

    Seibutsu Butsuri   48   S58   2008

    　More details

    Language：English   Publisher：The Biophysical Society of Japan General Incorporated Association  

    DOI： 10.2142/biophys.48.S58_2

    CiNii Article

    researchmap

  • 1P-240 Hemichannels involved in ATP release from taste cells with action potentials(The 46th Annual Meeting of the Biophysical Society of Japan)

    Murata Yoshihiro, Yoshida Ryusuke, Yasuo Toshiaki, Yanagawa Yuchio, Obata Kunihiko, Ueno Hiroshi, Margolskee Robert F., Ninomiya Yuzo

    Seibutsu Butsuri   48   S58   2008

    　More details

    Language：English   Publisher：The Biophysical Society of Japan General Incorporated Association  

    DOI： 10.2142/biophys.48.S58_5

    CiNii Article

    researchmap

  • Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor Reviewed

    Chihiro Hisatsune, Keiko Yasumatsu, Hiromi Takahashi-Iwanaga, Naoko Ogawa, Yukiko Kuroda, Ryusuke Yoshida, Yuzo Ninomiya, Katsuhiko Mikoshiba

    JOURNAL OF BIOLOGICAL CHEMISTRY   282 ( 51 )   37225 - 37231   2007.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1074/jbc.M705641200

    Web of Science

    researchmap

  • Glutamate responses of mouse fungiform taste cells with action potentials Reviewed

    Yoshihiro Murata, Ryusuke Yoshida, Toshiaki Yasuo, Keiko Yasumatsu, Noriatsu Shigemura, Yuzo Ninomiya

    NEUROSCIENCE RESEARCH   58   S217 - S217   2007

    　More details

  • Taste receptor cells generating action potentials within a single taste bud of mouse fungiform papillae Reviewed

    Ryusuke Yoshida, Yoshihiro Murata, Toshiaki Yasuo, Keiko Yasumatsu, Noriatsu Shigemura, Yuzo Ninomiya

    NEUROSCIENCE RESEARCH   58   S217 - S217   2007

    　More details

  • Coding channels for taste perception: information transmission from taste cells to gustatory nerve fibers Reviewed

    Ryusuke Yoshida, Keiko Yasumatsu, Noriatsu Shigemura, Yuzo Ninomiya

    ARCHIVES OF HISTOLOGY AND CYTOLOGY   69 ( 4 )   233 - 242   2006.12

    　More details

  • Taste responsiveness of fungiform taste cells with action potentials Reviewed

    Ryusuke Yoshida, Noriatsu Shigemura, Keisuke Sanematsu, Keiko Yasumatsu, Satoru Ishizuka, Yuzo Ninomiya

    JOURNAL OF NEUROPHYSIOLOGY   96 ( 6 )   3088 - 3095   2006.12

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1152/jn.00409.2006

    Web of Science

    researchmap

  • Amiloride inhibition on NaCl responses of the chorda tympani nerve in two 129 substrains of mice, 129P3/J and 129X1/SvJ Reviewed

    Tadahiro Ohkuri, Keiko Yasumatsu, Noriatsu Shigemura, Ryusuke Yoshida, Yuzo Ninomiya

    CHEMICAL SENSES   31 ( 6 )   565 - 572   2006.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/chemse/bjj061

    Web of Science

    researchmap

  • Trpm5 null mice respond to bitter, sweet, and umami compounds Reviewed

    S Damak, MQ Rong, K Yasumatsu, Z Kokrashvili, CA Perez, N Shigemura, R Yoshida, B Mosinger, JI Glendinning, Y Ninomiya, RF Margolskee

    CHEMICAL SENSES   31 ( 3 )   253 - 264   2006.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/chemse/bjj027

    Web of Science

    PubMed

    researchmap

  • Mouse strain differences in gurmarin-sensitivity of sweet taste responses are not associated with polymorphisms of the sweet receptor gene, Tas1r3 Reviewed

    K Sanematsu, K Yasumatsu, R Yoshida, N Shigemura, Y Ninomiya

    CHEMICAL SENSES   30 ( 6 )   491 - 496   2005.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/chemse/bji041

    Web of Science

    PubMed

    researchmap

  • Expression of amiloride-sensitive epithelial sodium channels in mouse taste cells after chorda tympani nerve crush Reviewed

    N Shigemura, AAS Islam, C Sadamitsu, R Yoshida, K Yasumatsu, Y Ninomiya

    CHEMICAL SENSES   30 ( 6 )   531 - 538   2005.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/chemse/bji046

    Web of Science

    PubMed

    researchmap

  • The role of the dpa locus in mice Reviewed

    N Shigemura, K Yasumatsu, R Yoshida, N Sako, H Katsukawa, K Nakashima, T Imoto, Y Ninomiya

    CHEMICAL SENSES   30   I84 - i85   2005.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/chemse/bjh125

    Web of Science

    PubMed

    researchmap

  • Taste receptor cells responding with action potentials to taste stimuli and their molecular expression of taste related genes Reviewed

    R Yoshida, K Sanematsu, N Shigemura, K Yasumatsu, Y Ninomiya

    CHEMICAL SENSES   30   I19 - i20   2005.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/chemse/bjh092

    Web of Science

    PubMed

    researchmap

  • Recovery of salt taste responses and PGP 9.5 immunoreactive taste bud cells during regeneration of the mouse chorda tympani nerve Reviewed

    K Yasumatsu, N Shigemura, R Yoshida, Y Ninomiya

    CHEMICAL SENSES   30   I62 - i63   2005.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/chemse/bjh114

    Web of Science

    PubMed

    researchmap

  • Search for cerebral G cluster neurons responding to taste stimulation with seaweed in Aplysia kurodai by the use of calcium imaging Reviewed

    R Yoshida, T Nagahama

    JOURNAL OF NEUROBIOLOGY   55 ( 3 )   299 - 314   2003.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/neu.10207

    Web of Science

    researchmap

  • The Study of Neural Network for Feeding Behavior by Calcium Imaging Method

    YOSHIDA Ryusuke, NAGAHAMA Tatsumi

    Seibutsu Butsuri   43 ( 1 )   15 - 20   2003.1

    　More details

    Language：Japanese   Publisher：The Biophysical Society of Japan General Incorporated Association  

    The conventional electrophysiological method revealed some aspects of neural network for animal behavior. But it was inappropriate for recording activities of many neurons simultaneously. For the purpose of the multi-cell recording from Aplysia central nervous system, we used the calcium imaging method. Spike activities could be recorded from-30 neurons simultaneously. We also demonstrated that the firing properties of individual neurons, such as frequency or period, and the phase-locked firing patterns of these neurons could be easily detected. Moreover, combining this method with the electrophysiological method, we could identify several motor neurons concerned with the feeding behavior of this animal.

    DOI： 10.2142/biophys.43.15

    CiNii Article

    CiNii Books

    researchmap

    Other Link： https://jlc.jst.go.jp/DN/JALC/00160735934?from=CiNii

  • 【分子を感じる 感覚の分子生物学】味を感じる:神経メカニズム

    安松 啓子, 三浦 裕仁, 吉田 竜介, 日野 明寛, 二ノ宮 裕三

    細胞工学   21 ( 12 )   1429 - 1433   2002.11

    　More details

    Language：Japanese   Publisher：(株)学研メディカル秀潤社  

    researchmap

  • 1C1100 Recordings of responses from taste cells elicited by taste stimuli to the single taste bud of mice.

    Yoshida R., Ishizuka S., Lindemaun Bernd, Ninomiya Y.

    Seibutsu Butsuri   42 ( 2 )   S21   2002

    　More details

    Language：Japanese   Publisher：The Biophysical Society of Japan General Incorporated Association  

    DOI： 10.2142/biophys.42.S21_3

    CiNii Article

    researchmap

  • Calcium imaging for detection and estimation of spike activities in Aplysia neurons Reviewed

    R Yoshida, A Iwamoto, T Nagahama

    ZOOLOGICAL SCIENCE   18 ( 5 )   631 - 643   2001.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.2108/zsj.18.631

    Web of Science

    researchmap

  • Differences in localization of calcium channnels and responses induced by neurotransm itters between MA1 and MA2 neurons in Aplysia feeding neural network.

    Iwamoto A., Yoshida R., Nagahama T.

    Seibutsu Butsuri   39   S52   1999

    　More details

    Language：Japanese   Publisher：The Biophysical Society of Japan General Incorporated Association  

    DOI： 10.2142/biophys.39.S52_1

    CiNii Article

    CiNii Books

    researchmap

▼display all

Books

  • Umami and MSG 「Umami: Taste for Health」

    Ryusuke Yoshida, Yuzo Ninomiya（ Role： Joint author）

    Elsevier  2023.9  （ ISBN:9783031326929 ）

    　More details

  • 味覚「口腔解剖学・口腔組織発生学・口腔生理学 : 歯・口腔の構造と機能」

    吉田竜介（ Role： Contributor ,  III-２-1 味覚）

    医歯薬出版  2022.3  （ ISBN:9784263426050 ）

    　More details

    Total pages：xvi, 296p   Language：Japanese

    CiNii Books

    researchmap

  • Sweet and Umami Taste「The Senses: A Comprehensive Reference, Reference Work, 2nd Edition」

    Ryusuke Yoshida, Yuzo Ninomiya

    Elsevier  2020.9 

    　More details

  • 味蕾

    吉田竜介（ Role： Sole author）

    脳科学辞典：日本神経科学学会  2018.4 

    　More details

  • レプチンによる甘味感受性調節機構 「おいしさの科学的評価・測定法と応用展開」

    吉田竜介, 二ノ宮裕三（63-74）

    CMC出版  2016.9 

    　More details

  • Peptide Signaling in Taste Transduction. 「Chemosensory Transduction: The Detection of Odors, Tastes, and Other Chemostimuli.」

    Takai S, Yoshida R, Shigemura N, Ninomiya Y

    Academic Press  2016.2 

    　More details

  • マウス味細胞応答記録法「研究者が教える動物実験・第１巻・感覚」

    吉田竜介

    共立出版  2015.7 

    　More details

  • 味覚「アミノ酸科学の最前線」

    吉田竜介

    CMC出版  2015.5 

    　More details

  • 味覚「基礎歯科生理学第６版」

    吉田竜介, 二ノ宮裕三

    医歯薬出版  2014.2 

    　More details

  • マウス「研究者が教える動物飼育－第３巻－」

    吉田竜介（154-158）

    共立出版  2012.5 

    　More details

▼display all

MISC

  • カプサイシンはマウス味覚神経応答を糖特異的に増強する

    岩田周介, 吉田竜介, 高橋慎平, 安尾敏明, 諏訪部武, 硲哲崇, 二ノ宮裕三, 二ノ宮裕三

    Journal of Oral Biosciences Supplement (Web)   2023   2023

    　More details

  • ラット唾液腺支配の上唾液核ニューロンに対するドーパミンの影響

    美藤純弘, 佐藤匡, 矢島健大, 堀江謙吾, 市川博之, 吉田竜介

    Journal of Oral Biosciences Supplement (Web)   2023   2023

    　More details

  • 研究室紹介 Invited

    吉田竜介

    日本味と匂学会誌   29 ( 2 )   113 - 116   2022.11

    　More details

    Authorship：Lead author,　Last author,　Corresponding author   Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

    researchmap

  • 持続的な甘味刺激が唾液分泌量に及ぼす影響

    山田 蘭子, 杉本 皓, 田中 祐貴, 北川 佳祐, 古寺 寛志, 足立 れいみ, 市川 知香, 松岸 諒, 森 慧太郎, 桑原 実穂, 萬田 陽介, 兒玉 直紀, 吉田 竜介, 皆木 省吾

    日本補綴歯科学会誌   14 ( 中国・四国支部学術大会特別号 )   22 - 22   2022.8

    　More details

    Language：Japanese   Publisher：(公社)日本補綴歯科学会  

    researchmap

  • Capsaicin enhances responses of the gustatory nerve to sugars and salt in mice

    岩田周介, 岩田周介, 吉田竜介, 高井信吾, 實松敬介, 實松敬介, 實松敬介, 重村憲徳, 重村憲徳, 二ノ宮裕三, 二ノ宮裕三

    Journal of Oral Biosciences Supplement (Web)   2022   2022

    　More details

  • 発酵乳成分におけるマウスの味覚応答の解析

    山瀬裕子, 黄海, 美藤純弘, 美藤純弘, 美藤純弘, 江草正彦, 宮脇卓也, 吉田竜介, 吉田竜介, 吉田竜介

    岡山歯学会雑誌   41 ( 2 )   2022

    　More details

  • 発酵乳成分に対する味覚応答

    山瀬裕子, 山瀬裕子, 黄海, 美藤純弘, 美藤純弘, 美藤純弘, 江草正彦, 宮脇卓也, 吉田竜介, 吉田竜介, 吉田竜介

    日本神経化学会大会抄録集(Web)   65th   2022

    　More details

  • 唾液腺支配の上唾液核ニューロンに対するドーパミンの影響

    美藤純弘, 佐藤匡, 矢島健大, 小橋基, 市川博之, 吉田竜介

    日本栄養・食糧学会中国・四国支部大会講演要旨集(CD-ROM)   55th   2022

    　More details

  • 唾液腺支配のラット上唾液核ニューロンに対する摂食亢進ペプチドの影響

    美藤純弘, 佐藤匡, 藤田雅子, 小橋基, 市川博之, 吉田竜介

    Journal of Oral Biosciences Supplement (Web)   2019   2019

    　More details

  • Gustatory responses of taste receptor cells expressing fluorescent proteins in transgenic mice

    Ryusuke Yoshida, Keiko Yasumatsu-Nakano, Keisuke Sanematsu, Noriatsu Shigemura, Yuzo Ninomiya

    CHEMICAL SENSES   41 ( 9 )   E115 - E115   2016.11

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Glucagon like peptide-1, sweet taste and metabolic modulation of peripheral taste information

    Shingo Takai, Noriatsu Shigemura, Keiko Yasumatsu-Nakano, Mayuko Inoue, Shusuke Iwata, Ryusuke Yoshida, Robert F. Margolskee, Yuzo Ninomiya

    CHEMICAL SENSES   41 ( 9 )   E128 - E128   2016.11

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Intracellular acidification is involved in full activation of the sweet taste receptor by miraculin

    Keisuke Sanematsu, Masayuki Kitagawa, Ryusuke Yoshida, Satoru Nirasawa, Noriatsu Shigemura, Yuzo Ninomiya

    CHEMICAL SENSES   41 ( 9 )   E276 - E276   2016.11

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • 味覚と健康 栄養素センサー研究の現状と未来 味覚受容体の機能(塩味と甘味)

    重村 憲徳, 吉田 竜介, 安松 啓子, 大栗 弾宏, 岩田 周介, 高井 信吾, 上瀧 将史, 仁木 麻由, 實松 敬介, 二ノ宮 祐三

    日本薬学会年会要旨集   136年会 ( 1 )   206 - 206   2016.3

    　More details

    Language：Japanese   Publisher：(公社)日本薬学会  

    researchmap

  • The function of glucagon-like peptide-1 in the mouse peripheral taste system

    Shingo Takai, Ryusuke Yoshida, Keiko Yasumatsu, Noriatsu Shigemura, Yuzo Ninomiya

    Journal of Oral Biosciences   58 ( 1 )   10 - 15   2016.2

    　More details

    Publishing type：Book review, literature introduction, etc.  

    DOI： 10.1016/j.job.2015.09.002

    Scopus

    researchmap

  • 甘味受容体を起点とした口腔脳腸の味情報 : 内分泌連関と食調節 (特集 第13回高付加価値食品開発のためのフォーラム)

    吉田 竜介, 二ノ宮 裕三

    食品加工技術 : 日本食品機械研究会誌   36 ( 1 )   30 - 38   2016

    　More details

    Language：Japanese   Publisher：日本食品機械研究会  

    CiNii Article

    CiNii Books

    researchmap

  • ホルモンによる味覚(塩味・甘味)感受性調節

    重村 憲徳, 吉田 竜介, 安松 啓子, 大栗 弾宏, 岩田 周介, 高井 信吾, 上瀧 将史, 仁木 麻由, 實松 敬介, 二ノ宮 裕三

    日本生物工学会大会講演要旨集   平成27年度   161 - 161   2015.9

    　More details

    Language：Japanese   Publisher：(公社)日本生物工学会  

    researchmap

  • 口腔生理学分野の研究最前線Frontier in the field of Oral Physiology エンドカンナビノイドによる自己増幅的甘味増強とT1R3-非依存的甘味受容経路の存在

    岩田 周介, 吉田 竜介, 重村 憲徳, 二ノ宮 裕三

    Journal of Oral Biosciences Supplement   2015   115 - 115   2015.9

    　More details

    Language：Japanese   Publisher：(一社)歯科基礎医学会  

    researchmap

  • 味細胞におけるエンドカンナビノイドを介した甘味応答の自己増幅

    岩田 周介, 吉田 竜介, 重村 憲徳, 二ノ宮 裕三

    Journal of Oral Biosciences Supplement   2015   295 - 295   2015.9

    　More details

    Language：Japanese   Publisher：(一社)歯科基礎医学会  

    researchmap

  • Involvement of CCK in normal gustatory responses to bitter compounds

    Misa Shin, Keiko Yasumatsu, Shingo Takai, Noriatsu Shigemura, Ryusuke Yoshida, Soichi Takiguchi, Seiji Nakamura, Yuzo Ninomiya

    CHEMICAL SENSES   40 ( 3 )   259 - 260   2015.3

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • 香辛料の味修飾作用及び消化管を介した代謝調節作用―3 ホルモンによる味覚修飾と摂食調節―アンジオテンシンIIと味覚―

    重村憲徳, 吉田竜介, 安松啓子, 大栗弾宏, 岩田周介, 高井信吾, 上瀧将史, 仁木麻由, 實松敬介, 二ノ宮裕三

    日本味と匂学会誌   21 ( 1 )   49 - 53   2014.4

    　More details

  • Involvement of multiple populations of taste cells and afferent neurons in umami taste detection

    Y. Ninomiya, K. Yasumatsu, R. Yoshida

    CHEMICAL SENSES   39 ( 1 )   77 - 77   2014.1

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • 味蕾から分泌される消化管ホルモンは味質特異的な情報伝達に関与する

    高井信吾, 安松啓子, 岩田周介, 井上真由子, 吉田竜介, 重村憲徳, DRUCKER Daniel J, MARGOLSKEE Robert F, 二ノ宮裕三, 二ノ宮裕三

    Journal of Oral Biosciences Supplement (Web)   2014   ROMBUNNO.SS11‐1 (WEB ONLY)   2014

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • Endogenous humoral modulators of behavioral preference for sweet and salty tastes

    Yuzo Ninomiya, Mayu Niki, Ryusuke Yoshida, Noriatsu Shigemura

    JOURNAL OF PHYSIOLOGICAL SCIENCES   63   S59 - S59   2013

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • 食欲調節物質による甘味感受性の調節

    吉田 竜介, 二ノ宮 裕三

    日本薬理學雜誌 = Folia pharmacologica Japonica   139 ( 3 )   131 - 131   2012.3

    　More details

  • Inhibition of sweet taste responses by AM251, an antagonist of endocannabinoid receptors in db/db mice

    NIKI Mayu, JYOTAKI Masafumi, YOSHIDA Ryusuke, NINOMIYA Yuzo

    The Japanese journal of taste and smell research   18 ( 3 )   255 - 258   2011.12

    　More details

    Language：Japanese   Publisher：The Japanese Association for the Study of Taste and Smell  

    CiNii Article

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2012174177

  • The taste organ is a target for orexigenic and anorexic mediators

    Yuzo Ninomiya, Mayu Niki, Tadahiro Ohkuri, Masafumi Jyotaki, Ryusuke Yoshida

    CHEMICAL SENSES   36 ( 1 )   E2 - E2   2011.1

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Expression of G alpha subunits in sweet and umami taste cells in mice

    Ryusuke Yoshida, Aya Miyauchi, Robert F. Margolskee, Yuzo Ninomiya

    NEUROSCIENCE RESEARCH   71   E154 - E154   2011

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    DOI： 10.1016/j.neures.2011.07.665

    Web of Science

    researchmap

  • Modulation of sweet sensitivity by endogenous leptin and endocannabinoid

    Mayu Niki, Masafumi Jyotaki, Tadahiro Ohkuri, Ryusuke Yoshida, Yuzo Ninomiya

    NEUROSCIENCE RESEARCH   71   E163 - E163   2011

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    DOI： 10.1016/j.neures.2011.07.703

    Web of Science

    researchmap

  • Involvement of mGluRs in umami detection in mice

    Yoko Kusuhara, Keiko Yasumatsu, Tadahiro Ohkuri, Ryusuke Yoshida, Katsumasa Maeda, Yuzo Ninomiya

    NEUROSCIENCE RESEARCH   71   E358 - E358   2011

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    DOI： 10.1016/j.neures.2011.07.1569

    Web of Science

    researchmap

  • Humoral modulation of sweet taste sensitivities for energy homeostasis

    Yuzo Ninomiya, Mayu Niki, Masafumi Jyotaki, Tadahiro Ohkuri, Ryusuke Yoshida

    NEUROSCIENCE RESEARCH   71   E40 - E41   2011

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    DOI： 10.1016/j.neures.2011.07.179

    Web of Science

    researchmap

  • Inhibition of sweet taste responses by AM251, an antagonist of endocannabinoid receptors in db/db mice

    NIKI Mayu, OHKURI Tadahiro, JYOTAKI Masafumi, YOSHIDA Ryusuke, NINOMIYA Yuzo

    The Japanese journal of taste and smell research   17 ( 3 )   231 - 234   2010.12

    　More details

    Language：Japanese   Publisher：The Japanese Association for the Study of Taste and Smell  

    CiNii Article

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2011206881

  • Influence of GABA on taste responses of mouse taste cells

    YASUO Toshiaki, YOSHIDA Ryusuke, YANAGAWA Yuchio, MARGOLSKEE Robert F, NINOMIYA Yuzo

    The Japanese journal of taste and smell research   17 ( 3 )   227 - 230   2010.12

    　More details

    Language：Japanese   Publisher：日本味と匂学会  

    CiNii Article

    CiNii Books

    researchmap

  • マウス味細胞の味応答に対するGABAの影響

    安尾敏明, 吉田竜介, 重村憲徳, 柳川右千夫, 二ノ宮裕三

    Journal of Oral Biosciences   52 ( Supplement )   100   2010.9

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • 味蕾内におけるGABAの応答特性

    安尾敏明, 吉田竜介, 堀尾奈央, 重村憲徳, 二ノ宮裕三

    日本生理学雑誌   72 ( 2 )   43   2010.2

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • GABA act as a modulator for sweet and bitter taste responses of mice taste bud cells

    Toshiaki Yasuo, Ryusuke Yoshida, Noriatsu Shigemura, Robert Margolskee, Yuzo Ninomiya

    JOURNAL OF PHYSIOLOGICAL SCIENCES   60   S143 - S143   2010

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Endocannabinoids enhance sweet taste sensitivities in mice

    Ryusuke Yoshida, Tadahiro Ohkuri, Masafumi Jyotaki, Toshiaki Yasuo, Nao Horio, Keiko Yasumatsu, Keisuke Sanematsu, Noriatsu Shigemura, Tsuneyuki Yamamoto, Robert F. Margolskee, Yuzo Ninomiya

    NEUROSCIENCE RESEARCH   68   E389 - E390   2010

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    DOI： 10.1016/j.neures.2010.07.1726

    Web of Science

    researchmap

  • GABA influence on taste cell responses in mice

    Toshiaki Yasuo, Ryusuke Yoshida, Noriatsu Shigemura, Robert F. Margolskee, Yuzo Ninomiya

    NEUROSCIENCE RESEARCH   68   E384 - E384   2010

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    DOI： 10.1016/j.neures.2010.07.1702

    Web of Science

    researchmap

  • Single nucleotide polymorphisms (SNP) in taste sensor genes and perceptual diversity

    Noriatsu Shigemura, Yoko Ogiwara, Keisuke Sanematsu, Misako Kawai, Ryusuke Yoshida, Yuzo Ninomiya

    JOURNAL OF PHYSIOLOGICAL SCIENCES   60   S73 - S73   2010

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • PKD2L1 is associated with the sour taste transduction

    Nao Horio, Ryusuke Yoshida, Keiko Yasumatsu, Yuchio Yanagawa, Yoshiro Ishimaru, Hiroaki Matsunami

    NEUROSCIENCE RESEARCH   68   E385 - E385   2010

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    DOI： 10.1016/j.neures.2010.07.1703

    Web of Science

    researchmap

  • GABA functions as neurotransmitter in the mice taste buds

    YASUO Toshiaki, YOSHIDA Ryusuke, HORIO Nao, SHIGEMURA Noriatsu, NINOMIYA Yuzo

    The Japanese journal of taste and smell research   16 ( 3 )   323 - 326   2009.12

    　More details

    Language：Japanese   Publisher：日本味と匂学会  

    CiNii Article

    CiNii Books

    researchmap

  • Different Response Properties between Type II and Type III Taste Bud Cells in Mouse Fungiform Papillae

    Ryusuke Yoshida, Toshiaki Yasuo, Yoshihiro Murata, Masashi Jyotaki, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Robert F. Margolskee, Yuzo Ninomiya

    CHEMICAL SENSES   34 ( 7 )   A72 - A72   2009.9

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Genetic and Molecular Basis of Individual Differences in Human Umami Taste Perception

    Noriatsu Shigemura, Shinya Shirosaki, Keisuke Sanematsu, Yoko Ogiwara, Misako Kawai, Ryusuke Yoshida, Yuzo Ninomiya

    CHEMICAL SENSES   34 ( 7 )   A63 - A63   2009.9

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • The role of taste bud cells on the coding of taste information

    YOSHIDA Ryusuke, NINOMIYA Yuzo

    The Japanese journal of taste and smell research   16 ( 2 )   117 - 124   2009.8

    　More details

    Language：Japanese   Publisher：The Japanese Association for the Study of Taste and Smell  

    CiNii Article

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2010076314

  • Taste Signal Transnission from Fungiform Taste Bud Cells to Chorda Tympani Nerve Fibers in Mice

    Ryusuke Yoshida, Yoshinori Murata, Toshiaki Yasuo, Keiko Yasumatsu, Noriatsu Shigemura, Yuzo Ninomiya

    CHEMICAL SENSES   34 ( 3 )   E30 - E30   2009.3

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Firing Frequency-Dependent ATP Release from Type II Taste Cells in Mice

    Yoshihiro Murata, Ryusuke Yoshida, Toshiaki Yasuo, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Robert F. Margolskee, Yuzo Ninomiya

    CHEMICAL SENSES   34 ( 2 )   J8 - J8   2009.2

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Cell Types and Response Properties of Mouse Fungiform Taste Cells

    Ryusuke Yoshida, Yoshihiro Murata, Toshiaki Yasuo, Masashi Jyotaki, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Robert F. Margolskee, Yuzo Ninomiya

    CHEMICAL SENSES   34 ( 2 )   J2 - J2   2009.2

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Sweet sensing for regulation of food intake

    Yuzo Ninomiya, Keisuke Sanematsu, Masahumi Johtaki, Ryusuke Yoshida, Noriatsu Shigemura

    JOURNAL OF PHARMACOLOGICAL SCIENCES   109   46P - 46P   2009

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Functional analysis of T1R1/T1R3 umami taste receptor variants

    Noriatsu Shigemura, Shinya Shirosaki, Keisuke Sanematsu, Yoko Ogiwara, Misako Kawai, Ryusuke Yoshida, Yuzo Ninomiya

    NEUROSCIENCE RESEARCH   65   S176 - S176   2009

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    DOI： 10.1016/j.neures.2009.09.934

    Web of Science

    researchmap

  • Responses of mouse fungiform taste cells to multiple bitter or sour taste compounds

    Ryusuke Yoshida, Toshiaki Yasuo, Aya Miyauchi, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Robert F. Margolskee, Yuzo Ninomiya

    NEUROSCIENCE RESEARCH   65   S175 - S175   2009

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    DOI： 10.1016/j.neures.2009.09.926

    Web of Science

    researchmap

  • FUNCTIONAL EXPRESSION STUDY OF TAS1R1/TAS1R3 RECEPTOR VARIANTS ASSOCIATED WITH INDIVIDUAL DIFFERENCES IN HUMAN UMAMI TASTE SENSITIVITY

    Noriatsu Shigemura, Shinya Shirosaki, Keisuke Sanematsu, Yoko Ogiwara, Misako Kawai, Ryusuke Yoshida, Yuzo Ninomiya

    JOURNAL OF PHYSIOLOGICAL SCIENCES   59   488 - 488   2009

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • TASTE RESPONSIVENESS OF TYPE II AND III TASTE BUD CELLS IN MOUSE FUNGIFORM PAPILLAE

    Ryusuke Yoshida, Toshiaki Yasuo, Yoshihiro Murata, Masashi Jyotaki, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Sami Damak, Robert F. Margolskee, Yuzo Ninomiya

    JOURNAL OF PHYSIOLOGICAL SCIENCES   59   148 - 148   2009

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Effects of antagonists for mGluRs on behavioral responses in C57BL/6 and T1R3-KO mice

    SHIROSAKI Shinya, KAWATO Yuriko, NAKASHIMA Kiyohito, SHIGEMURA Noriatsu, YASUMATSU Keiko, YOSHIDA Ryusuke, MARGOLSKEE Robert F, NINOMIYA Yuzo

    The Japanese journal of taste and smell research   15 ( 3 )   293 - 296   2008.12

    　More details

    Language：Japanese   Publisher：The Japanese Association for the Study of Taste and Smell  

    CiNii Article

    CiNii Books

    researchmap

  • Modulation and Transmission of Sweet Taste Information for Energy Homeostasis

    Yuzo Ninomiya, Ryusuke Yoshida, Yoshihiro Murata, Keiko Yasumatsu, Tadahiro Ohkuri, Shinya Shirosaki, Keisuke Sanematsu, Toshiaki Yasuo, Yuki Nakamura, Noriatsu Shigemura

    CHEMICAL SENSES   33 ( 8 )   S23 - S23   2008.10

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Firing Rate-Dependent ATP Release from Mouse Fungiform Taste Cells with Action Potentials

    Yoshihiro Murata, Ryusuke Yoshida, Toshiaki Yasuo, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Robert F. Margolskee, Yuzo Ninomiya

    CHEMICAL SENSES   33 ( 8 )   S128 - S128   2008.10

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Multiple Receptor Systems for Umami Taste in Mice

    Ryusuke Yoshida, Keiko Yasumatsu, Shinya Shirosaki, Yuriko Kawato, Yoshihiro Murata, Noriatsu Shigemura, Kiyohito Nakashima, Robert F. Margolskee, Yuzo Ninomiya

    CHEMICAL SENSES   33 ( 8 )   S5 - S5   2008.10

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • GFPノックインマウスを用いたII型およびIII型味細胞の応答特性の解析

    吉田竜介, 村田芳博, 安尾敏明, 上瀧将史, 安松啓子, 重村憲徳, 二ノ宮裕三

    Journal of Oral Biosciences   50 ( Supplement )   189   2008.9

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • II型味細胞は活動電位の頻度に依存してATPを放出する

    村田芳博, 安尾敏明, 吉田竜介, 二ノ宮裕三

    Journal of Oral Biosciences   50 ( Supplement )   189   2008.9

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • 単一味蕾内の複数の味細胞の応答特性

    吉田竜介, 安尾敏明, 村田芳博, 上瀧将史, 二ノ宮裕三

    日本生理学雑誌   70 ( 2 )   59   2008.2

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • マウス茸状乳頭味細胞の活動電位依存性ATP放出

    村田芳博, 安尾敏明, 吉田竜介, 二ノ宮裕三

    日本生理学雑誌   70 ( 2 )   60   2008.2

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • ATP release from mouse fungiform taste cells with action potentials

    Y. Murata, T. Yasuo, R. Yoshida, Y. Ninomiya

    CHEMICAL SENSES   33 ( 2 )   J11 - J11   2008.2

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Analysis of taste responsiveness of subsets of receptor cells in the mouse single fungiform taste bud

    R. Yoshida, T. Yasuo, Y. Murata, M. Jyotaki, Y. Ninomiya

    CHEMICAL SENSES   33 ( 2 )   J11 - J11   2008.2

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • マウスII型味細胞の発火頻度依存性ATP放出

    村田芳博, 吉田竜介, 安尾敏明, 柳川右千夫, 小幡邦彦, 植野洋志, Margolskee, R.F, 二ノ宮裕三

    日本味と匂学会誌   15 ( 3 )   381 - 384   2008

    　More details

    Language：Japanese   Publisher：日本味と匂学会  

    researchmap

  • ATP release from type II taste cells depending on firing rate

    Yoshihiro Murata, Ryusuke Yoshida, Toshiaki Yasuo, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Robert F. Margolskee, Yuzo Ninomiya

    NEUROSCIENCE RESEARCH   61   S178 - S178   2008

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Abnormal taste perception in mine lacking the Type 3 IP3 Receptor

    Chihiro Hisatsune, Keiko Yasumatsu, Hiromi Takahashi-Iwanaga, Naoko Ogawa, Yukiko Kuroda, Ryusuke Yoshida, Yuzo Ninomiya, Katsuhiko Mikoshiba

    NEUROSCIENCE RESEARCH   61   S249 - S249   2008

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Analysis of signal transductions for umami taste by single fiber recordings in the chorda tympani nerve of T1R3-and TRPM5-KO mice

    Keiko Yasumatsu, Ryusuke Yoshida, Robert F. Margolskee, Yuzo Ninomiya

    NEUROSCIENCE RESEARCH   61   S179 - S179   2008

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Different response properties among cell types of taste receptor cells

    Ryusuke Yoshida, Yoshihiro Murata, Toshiaki Yasuo, Masashi Jyotaki, Yuchio Yanagawa, Kunihiko Obata, Hiroshi Ueno, Robert F. Margolskee, Yuzo Ninomiya

    NEUROSCIENCE RESEARCH   61   S248 - S248   2008

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • 味細胞の細胞型と応答特性

    植野 洋志, 吉田 竜介

    日本味と匂学会誌   15 ( 3 )   285 - 288   2008

    　More details

    Language：Japanese   Publisher：日本味と匂学会  

    researchmap

  • Firing rate dependent ATP release from type II and type III taste cells in mice

    Murata Yoshihiro, Yoshida Ryusuke, Yasuo Toshiaki, Yanagawa Yuchio, Obata Kunihiko, Ueno Hiroshi, Margolskee Robert F, Ninomiya Yuzo

    Proc Annu Meet PSJ   2008 ( 0 )   167 - 167   2008

    　More details

    Publisher：一般社団法人 日本生理学会  

    Taste signals are transmitted from taste cells to gustatory nerve fibers through chemical synapses. Taste cells are morphologically classified into four types: I, II, III and basal cells. Among them, chemical synapses are observed only in type III cells with putative sour receptors. However, sweet, bitter and umami receptors are expressed in type II cells, and the mechanisms have not been elucidated. Recent reports have highlighted the role of ATP as a key neurotransmitter. Here we tried to detect ATP release from single taste cells with action potentials in mouse fungiform papillae. The action potentials were recorded with the electrode basolaterally attached to a cell. When an increase in the firing rate was observed in response to a tastant, the electrode solution was applied for luciferase assay to determine the ATP. Type II and III cells express gustducin and glutamic acid decarboxylase (GAD67), respectively. We identified these cell types with transgenic mice expressing GFP in gustducin- or GAD67-positive cells. When Type II cells responded to saccharin or quinine, ATP was detected in a firing rate-dependent manner. When Type III cells increased the firing rate by application of HCl, ATP was below the detection limit. The results suggest that the amount of ATP released from taste cells differ with the response properties, or that type III cells release another neurotransmitter. &lt;b&gt;[J Physiol Sci. 2008;58 Suppl:S167]&lt;/b&gt;

    CiNii Article

    researchmap

  • Modulation of sweet taste responses by addition of NaCl, HCl and QHCl in the chorda tympani nerve of wild type and TRPM5-KO mice

    YASUMATSU Keiko, OHKURI Tadahiro, YOSHIDA Ryusuke, DAMAK Sami, MARGOLSKEE Robert F, NINOMIYA Yuzo

    The Japanese journal of taste and smell research   14 ( 3 )   387 - 390   2007.12

    　More details

    Language：Japanese   Publisher：The Japanese Association for the Study of Taste and Smell  

    CiNii Article

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2008133744

  • Conditioned taste aversion for umami substances in T1R3-knockout mice

    SHIROSAKI Shinya, KAWATO Yuriko, NAKASHIMA Kiyohito, SHIGEMURA Noriatsu, YASUMATSU Keiko, YOSHIDA Ryusuke, MARGOLSKEE Robert F., NINOMIYA Yuzo

    The Japanese journal of taste and smell research   14 ( 3 )   379 - 382   2007.12

    　More details

    Language：Japanese   Publisher：The Japanese Association for the Study of Taste and Smell  

    CiNii Article

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2008133742

  • 単一味蕾中の複数の味受容細胞は様々な応答特性を持つ

    吉田竜介, 安尾敏明, 村田芳博, 安松啓子, 重村憲徳, 二ノ宮裕三

    Journal of Oral Biosciences   49 ( Supplement )   171   2007.8

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • マウス味細胞の味刺激応答とATP放出

    村田芳博, 安尾敏明, 吉田竜介, 二ノ宮裕三

    Journal of Oral Biosciences   49 ( Supplement )   172   2007.8

    　More details

    Language：Japanese  

    J-GLOBAL

    researchmap

  • Taste receptor cells with action potentials as an initiation site for the gustatory information transduction pathway

    YOSHIDA Ryusuke, YASUMATSU Keiko, NINOMIYA Yuzo

    The Japanese journal of taste and smell research   14 ( 2 )   163 - 170   2007.8

    　More details

    Language：Japanese   Publisher：The Japanese Association for the Study of Taste and Smell  

    CiNii Article

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2008064681

  • The Role of Trpm5 in Thermal Sensitivity of Sweet Taste

    SHIGEMURA Noriatsu, YASUMATSU Keiko, YOSHIDA Ryusuke, NINOMIYA Yuzo

    Cryobiology and cryotechnology   53 ( 1 )   53 - 55   2007.6

    　More details

    Language：Japanese   Publisher：Japanese Society for Cryobiology and Cryotechnology  

    Trpm5, calcium-activated cation channel of the TRP superfamily, is highly expressed in taste buds of the tongue, where it has a key role in the perception of sweet, umami and bitter tastes. Activation of Trpm5 occurs downstream of the activation of G-protein-coupled taste receptors and is proposed to generate a depolarizing potential in the taste receptor cells. Factors that modulate Trpm5 activity are therefore expected to influence taste. Here we show that Trpm5 is a highly temperature-sensitive, heat-activated channel: inward Trpm5 currents increase steeply at temperatures between 15 and 35 degrees C. Heat activation is due to a temperature-dependent shift of the activation curve, in analogy to other thermosensitive TRP channels. Moreover, we show that increasing temperature between 15 and 35 degrees C markedly enhances the gustatory nerve response to sweet compounds in wild-type but not in Trpm5 knockout mice. The strong temperature sensitivity of Trpm5 may underlie known effects of temperature on perceived taste in humans, including enhanced sweetness perception at high temperatures and 'thermal taste`, the phenomenon whereby heating or cooling of the tongue evoke sensations of taste in the absence of tastants.

    CiNii Article

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2008081022

  • Analysis of salt taste signal transduction using salty peptides and KT-1 cells

    T. Ookura, K. Yasumatsu, Y. Ito, R. Yoshida, T. Kawai, Y. Kusakabe, Y. Shindo, A. Hino, Y. Ninomiya

    CHEMICAL SENSES   32 ( 2 )   J2 - J2   2007.2

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Behavioral analysis of responses to sweet substances in T1R3-KO mice

    S. Shirosaki, R. Yoshida, N. Shigemura, K. Yasumatsu, R. F. Margolskee, Y. Ninomiya

    CHEMICAL SENSES   32 ( 2 )   J5 - J6   2007.2

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Temperature dependency of the chorda tympani nerve response to sweeteners in C57BL/6N and BALB/c mice

    T. Ohkuri, K. Yasumatsu, R. Yoshida, N. Shigemura, Y. Ninomiya

    CHEMICAL SENSES   32 ( 2 )   J5 - J5   2007.2

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Relation of polymorphisms of ENaC Subunits to mouse strain differences in amiloride sensitive salt responses

    N. Shigemura, T. Ohkuri, C. Sadamitsu, K. Yasumatsu, R. Yoshida, G. K. Beauchamp, A. Bachimanov, Y. Ninomiya

    CHEMICAL SENSES   32 ( 2 )   J6 - J6   2007.2

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Response properties of NaCl responsive taste cells in mouse fungiform papillae: Amiloride-sensitive and insensitive taste cells

    R. Yoshida, T. Ohkuri, K. Yasumatsu, N. Shigemura, Y. Ninomiya

    CHEMICAL SENSES   32 ( 2 )   J6 - J6   2007.2

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Association between polymorphism of the sweet receptor gene, Tas1r3 and gurmarin sensitivity

    K. Sanematsu, K. Yasumatsu, R. Yoshida, N. Shigemura, Y. Ninomiya

    CHEMICAL SENSES   32 ( 2 )   J5 - J5   2007.2

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Polymorphisms of ENaC subunits relate to mouse strain differences in amiloride sensitive salt responses

    Noriatsu Shigemura, Tadahiro Ohkuri, Chiharu Sadamitsu, Keiko Yasumatsu, Ryusuke Yoshida, Gary K. Beauchamp, Alexander A. Bachmanov, Yuzo Ninomiya

    NEUROSCIENCE RESEARCH   58   S217 - S217   2007

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • マウス茸状乳頭味細胞のATP放出

    村田芳博, 安尾敏明, 吉田竜介, 二ノ宮裕三

    日本味と匂学会誌   14 ( 3 )   391 - 394   2007

    　More details

  • 単一細胞応答の観点からみたマウス茸状乳頭味蕾の応答性

    吉田竜介, 安尾敏明, 村田芳博, 上瀧将史, 二ノ宮裕三

    日本味と匂学会誌   14 ( 3 )   395 - 398   2007

    　More details

  • 1P179 ATP release from mouse taste cells with action potentials in response to a tastant(Chemoreception,Poster Presentations)

    Murata Yoshihiro, Yoshida Ryusuke, Yasuo Toshiaki, Yanagawa Yuchio, Obata Kunihiko, Ueno Hiroshi, Margolskee Robert F, Ninomiya Yuzo

    Seibutsu Butsuri   47 ( 0 )   S68   2007

    　More details

    Language：English   Publisher：一般社団法人 日本生物物理学会  

    DOI： 10.2142/biophys.47.S68_2

    CiNii Article

    researchmap

  • 1P180 Differences in response properties among cell types of taste cells(Chemoreception,Poster Presentations)

    Yoshida Ryusuke, Murata Yoshihiro, Yasuo Toshiaki, Jyotaki Masashi, Yanagawa Yuchio, Obata Kunihiko, Ueno Hiroshi, Margolskee Robert F, Ninomiya Yuzo

    Seibutsu Butsuri   47 ( 0 )   S68   2007

    　More details

    Language：English   Publisher：一般社団法人 日本生物物理学会  

    DOI： 10.2142/biophys.47.S68_3

    CiNii Article

    researchmap

  • Modulations of sweet taste responses by salts, acids and bitter compounds in the mouse chorda tympani nerve

    Keiko Yasumatsu, Ryusuke Yoshida, Robert F. Margolskee, Yuzo Ninomiya

    NEUROSCIENCE RESEARCH   58   S217 - S217   2007

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Relation of polymorphisms of ENaC subunits to mouse strain differences in amiloride sensitive salt responses

    SHIGEMURA Noriatsu, OHKURI Tadahiro, SADAMITSU Chiharu, YASUMATSU Keiko, YOSHIDA Ryusuke, BACHMANOV Alexander A., BEAUCHAMP Gary K., NINOMIYA Yuzo

    The Japanese journal of taste and smell research   13 ( 3 )   355 - 358   2006.12

    　More details

    Language：Japanese   Publisher：The Japanese Association for the Study of Taste and Smell  

    CiNii Article

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2007133450

  • Temperature dependency of the chorda tympani nerve response to sweeteners in C57BL/6N and BALB/c mice

    OHKURI Tadahiro, YASUMATSU Keiko, YOSHIDA Ryusuke, SHIGEMURA Noriatsu, NINOMIYA Yuzo

    The Japanese journal of taste and smell research   13 ( 3 )   339 - 342   2006.12

    　More details

    Language：Japanese   Publisher：The Japanese Association for the Study of Taste and Smell  

    CiNii Article

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2007133448

  • Association between polymorphism of the sweet receptor gene, Tas1r3 and gurmarin-sensitivity

    SANEMATSU Keisuke, YASUMATSU Keiko, YOSHIDA Ryusuke, SHIGEMURA Noriatsu, NINOMIYA Yuzo

    The Japanese journal of taste and smell research   13 ( 3 )   343 - 346   2006.12

    　More details

    Language：Japanese   Publisher：The Japanese Association for the Study of Taste and Smell  

    CiNii Article

    CiNii Books

    researchmap

  • Response properties of NaCl responsive taste cells in mouse fungiform papillae : Amiloride -sensitive and -insensitive taste cells

    YOSHIDA Ryusuke, OHKURI Tadahiro, YASUMATSU Keiko, SHIGEMURA Noriatsu, NINOMIYA Yuzo

    The Japanese journal of taste and smell research   13 ( 3 )   351 - 354   2006.12

    　More details

    Language：Japanese   Publisher：The Japanese Association for the Study of Taste and Smell  

    CiNii Article

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2007133449

  • Analysis of salt taste signal transduction using salt taste enhancers and KT-1 cells

    OOKURA Tetsuya, YASUMATSU Keiko, ITO Yumiko, YOSHIDA Ryusuke, KAWAI Takayuki, KUSAKABE Yuko, SHINDO Yoichiro, HINO Akihiro, NINOMIYA Yuzo

    The Japanese journal of taste and smell research   13 ( 3 )   279 - 280   2006.12

    　More details

    Language：Japanese   Publisher：The Japanese Association for the Study of Taste and Smell  

    CiNii Article

    CiNii Books

    researchmap

  • Behavioral analysis of responses to sweet substances in T1R3-KO mice

    SHIROSAKI Shinya, SHIGEMURA Noriatsu, YOSHIDA Ryusuke, YASUMATSU Keiko, MARGOLSKEE Robert F., NINOMIYA Yuzo

    The Japanese journal of taste and smell research   13 ( 3 )   347 - 350   2006.12

    　More details

    Language：Japanese   Publisher：The Japanese Association for the Study of Taste and Smell  

    CiNii Article

    CiNii Books

    researchmap

  • Analysis of residual responses to umami compounds in the chorda tympani nerve fiber of T1R3- and TRPM5-KO mice

    YASUMATSU Keiko, YOSHIDA Ryusuke, SHIGEMURA Noriatsu, DAMAK Sami, MARGOLSKEE Robert F., NINOMIYA Yuzo

    The Japanese journal of taste and smell research   13 ( 3 )   335 - 338   2006.12

    　More details

    Language：Japanese   Publisher：The Japanese Association for the Study of Taste and Smell  

    CiNii Article

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2007133447

  • Multiple receptors, transduction pathways and fiber types underlie umami taste in mice

    K. Yasumatsu, R. Yoshida, N. Shigemura, S. Damak, R. F. Margolskee, Y. Ninomiya

    CHEMICAL SENSES   31 ( 8 )   E88 - E89   2006.10

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Functional roles of taste signals on regulation of food intake

    Shigemura Noriatsu, Nakamura Yuki, Yoshida Ryusuke, Ninomiya Yuzo

    The Japanese journal of taste and smell research   13 ( 2 )   125 - 132   2006.8

    　More details

    Language：Japanese   Publisher：The Japanese Association for the Study of Taste and Smell  

    CiNii Article

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2007008750

  • Formation of taste neural coding channels

    R Yoshida, N Shigemura, K Yasumatsu, Y Ninomiya

    CHEMICAL SENSES   31 ( 1 )   J2 - J3   2006.1

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Behavioral analysis of responses to quinine in Trpm5 KO mice

    S Shirosaki, R Yoshida, N Shigemura, K Yasumatsu, RF Margolskee, Y Ninomiya

    CHEMICAL SENSES   31 ( 1 )   J12 - J12   2006.1

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • NaCl induced responses of mouse fungiform taste cells: existence of amiloride sensitive and insensitive taste cells

    Ryusuke Yoshida, Tadahiro Ohkuri, Keiko Yasumatsu, Noriatsu Shigemura, Yuzo Ninomiya

    NEUROSCIENCE RESEARCH   55   S251 - S251   2006

    　More details

    Language：English   Publishing type：Research paper, summary (international conference)  

    Web of Science

    researchmap

  • Behavioral analysis of responses to quinine in TRPM5 KO mice

    SHIROSAKI Shinya, SHIGEMURA Noriatsu, YOSHIDA Ryusuke, YASUMATSU Keiko, MARGOLSKEE Robert F., NINOMIYA Yuzo

    The Japanese journal of taste and smell research   12 ( 3 )   373 - 376   2005.12

    　More details

    Language：Japanese   Publisher：The Japanese Association for the Study of Taste and Smell  

    CiNii Article

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2006092876

  • Formation of taste neural coding channels

    YOSHIDA Ryusuke, SHIGEMURA Noriatsu, YASUMATSU Keiko, NINOMIYA Yuzo

    The Japanese journal of taste and smell research   12 ( 3 )   259 - 262   2005.12

    　More details

    Language：Japanese   Publisher：The Japanese Association for the Study of Taste and Smell  

    CiNii Article

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2006081417

  • レプチンによる甘味感受性の修飾 (特集・味覚のメカニズムに迫る)

    吉田 竜介, 重村 憲徳, 安松 啓子

    生体の科学   56 ( 2 )   109 - 113   2005.3

    　More details

    Language：Japanese   Publisher：金原一郎記念医学医療振興財団  

    CiNii Article

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2005161594

  • Abstracts of the 27th Annual Meeting of the Japan Neuroscience Society and the 3rd Joint Meeting of the Japan Neuroscience Society and the Japanese Society for Neurochemistry (Neuro 2004) (vol 51, pg 219, 2005)

    K Yasumatsu, N Shigemura, R Yoshida, S Damak, RF Margolskee, Y Ninomiya

    NEUROSCIENCE RESEARCH   51 ( 2 )   219 - 219   2005.2

    　More details

  • dpa(D-フェニルアラニン感受性)コンジェニックマウスにおける甘味感受性関連遺伝子の発現

    重村 憲徳, 安松 啓子, 吉田 竜介, 二ノ宮 裕三

    Journal of oral biosciences   46 ( 5 )   413 - 413   2004.9

    　More details

    Language：Japanese   Publisher：歯科基礎医学会  

    CiNii Article

    CiNii Books

    researchmap

  • 甘味受容・情報伝達経路の遺伝子ノックアウトマウスを用いた解析

    安松 啓子, 重村 憲徳, 吉田 竜介, 二ノ宮 裕三

    Journal of oral biosciences   46 ( 5 )   441 - 441   2004.9

    　More details

    Language：Japanese   Publisher：歯科基礎医学会  

    CiNii Article

    CiNii Books

    researchmap

  • マウス甘味応答細胞におけるTlr3とgustducinの発現

    吉田 竜介, 重村 憲徳, 安松 啓子, 二ノ宮 裕三

    Journal of oral biosciences   46 ( 5 )   470 - 470   2004.9

    　More details

    Language：Japanese   Publisher：歯科基礎医学会  

    CiNii Article

    CiNii Books

    researchmap

  • 食塩嗜好と味細胞応答:アンギオテンシン2による修飾

    二ノ宮 裕三, 重村 憲徳, 吉田 竜介

    助成研究報告集   2004   245 - 254   2004

    　More details

    Language：Japanese   Publisher：ソルト・サイエンス研究財団  

    CiNii Article

    CiNii Books

    researchmap

  • 統計学的解析法による味刺激に対する味細胞の応答性の検討 (2003年度日本味と匂学会第37回大会(9月24-26日、岡山))

    吉田 竜介, 重村 憲徳, 安松 啓子

    日本味と匂学会誌   10 ( 3 )   659 - 662   2003.12

    　More details

    Language：Japanese   Publisher：「日本味と匂学会」事務局  

    CiNii Article

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2004268785

  • 味神経に依存した味蕾の維持と再生:味覚感受性および味覚受容体分子の再発現

    二ノ宮 裕三, 重村 憲徳, 安松 啓子, 吉田 竜介

    歯科基礎医学会雑誌   45 ( 5 )   257 - 257   2003.9

    　More details

    Language：Japanese   Publisher：歯科基礎医学会  

    CiNii Article

    CiNii Books

    researchmap

  • マウス茸状乳頭の味細胞の応答性 : ルーズパッチ法による味細胞応答の記録

    吉田 竜介, 石塚 智, 重村 憲徳, 安松 啓子, 二ノ宮 裕三

    歯科基礎医学会雑誌   45 ( 5 )   349 - 349   2003.9

    　More details

    Language：Japanese   Publisher：歯科基礎医学会  

    CiNii Article

    CiNii Books

    researchmap

  • New experimental setup for recording of electrical signals from taste bud cells of mice

    YOSHIDA Ryusuke, ISHIZUKA Satoru, NINOMIYA Yuzo

    The Japanese journal of taste and smell research   9 ( 3 )   507 - 510   2002.12

    　More details

    Language：Japanese   Publisher：The Japanese Association for the Study of Taste and Smell  

    CiNii Article

    CiNii Books

    researchmap

  • 味を感じる:神経メカニズム (特集1 分子を感じる:感覚の分子生物学)

    安松 啓子, 三浦 裕仁, 吉田 竜介

    細胞工学   21 ( 12 )   1429 - 1433   2002.12

    　More details

    Language：Japanese   Publisher：秀潤社  

    CiNii Article

    CiNii Books

    researchmap

    Other Link： http://search.jamas.or.jp/link/ui/2003145795

▼display all

Presentations

  • Signaling cascade for the sweet suppressive effect of leptin

    Ryusuke Yoshida

    The 18th ISMNTOP  2019.11.3 

    　More details

    Event date： 2019.11.2 - 2019.11.3

    researchmap

  • 食における味覚の役割 Invited

    吉田竜介

    令和６年度公益社団法人日本補綴歯科学会中国・四国支部学術大会  2024.9.1 

    　More details

  • 味覚と健口 Invited

    吉田竜介

    第３０回日本未病学会学術総会  2023.12.16 

    　More details

    Presentation type：Oral presentation (invited, special)  

    researchmap

  • 味覚関連遺伝子の発現と機能：酸味を中心に Invited

    吉田竜介

    第52回 日本栄養・食糧学会北海道支部大会  2022.10.1 

    　More details

    Presentation type：Oral presentation (invited, special)  

    researchmap

  • 体内甘味受容機構とその役割 Invited

    吉田竜介

    感覚研究コンソーシアム・第 １ 回味覚ワーキンググループ 「舌と味覚」  2021.5.14 

    　More details

    Presentation type：Oral presentation (invited, special)  

    researchmap

  • 末梢における味覚情報処理 Invited

    吉田 竜介

    第40回岡山歯学会総会・学術集会  2019.12.15 

    　More details

  • 塩による甘味増強のメカニズム

    吉田竜介, 實松敬介

    ソルトサイエンス研究財団 平成30年度助成研究発表会  2019.7.25 

    　More details

  • 味覚と健康 Invited

    吉田 竜介

    第2回健康食品管理士会中国支部研修会  2019.1.27 

    　More details

    Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    researchmap

  • 味細胞におけるレプチンシグナリング Invited

    吉田 竜介

    第52回味と匂学会大会  2018.10.29 

    　More details

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    researchmap

  • 末梢における甘味の受容と調節メカニズム Invited

    吉田 竜介

    第６０回歯科基礎医学会学術大会  2018.9.6 

    　More details

    Language：Japanese   Presentation type：Oral presentation (invited, special)  

    researchmap

  • From Kyushu to Okayama: My research history Invited

    Ryusuke Yoshida

    Kyudai Oral Bioscience & OBT Research Center Joint International Symposium 2019  2018.3.2 

    　More details

▼display all

Awards

  • 学生奨励賞

    2024.11   第57回日本栄養・食糧学会中国四国支部大会  

    三上彩可, 黄海, 兵藤藍子, 堀江謙吾, 安松啓子, 二ノ宮裕三, 美藤純弘, 飯田征二, 吉田竜介

    　More details

  • 唾液関連優秀論文賞

    2024.11   第3回日本唾液ケア研究会学術大会  

    兵藤藍子, 三上彩可, 堀江謙吾, 美藤純弘, 二ノ宮裕三, 飯田征二, 吉田竜介

    　More details

  • 優秀発表賞

    2024.9   日本味と匂学会  

    堀江 謙吾, 黄 海, 王 寛宇, 左 玉, 美藤 純弘, 吉田 竜介

    　More details

  • Excellent Papers in JPS

    2024.2   Sugar signals from oral glucose transporters elicit cephalic-phase insulin release in mice

    Takamori M, Mitoh Y, Horie K, Egusa M, Miyawaki T, Yoshida R.

    　More details

  • 歯科基礎医学会賞生理学部門

    2011.11   歯科基礎医学会  

    吉田 竜介

    　More details

  • 研究奨励賞

    2010.9   日本味と匂学会  

    吉田 竜介

    　More details

  • 優秀ポスター発表賞生理学部門

    2005.9   歯科基礎医学会  

    吉田 竜介

    　More details

▼display all

Research Projects

  • Elucidation of the mechanism of taste cell shedding and its application to model mice for neurological disorders

    Grant number：24K22186  2024.06 - 2027.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    吉田 竜介, 美藤 純弘, 堀江 謙吾

    　 More details

    Grant amount：\6370000 （ Direct expense: \4900000 、 Indirect expense：\1470000 ）

    researchmap

  • うま味でサルコペニア克服に挑戦する

    Grant number：22K19634  2022.06 - 2025.03

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

    古株 彰一郎, 中道 敦子, 吉田 竜介, 細見 周平

    　 More details

    Grant amount：\6370000 （ Direct expense: \4900000 、 Indirect expense：\1470000 ）

    researchmap

  • 口腔機能低下症に迷走神経刺激は有効か：脳腸連関によるニューロモジュレーション解析

    Grant number：22K10246  2022.04 - 2025.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    植田 紘貴, 吉田 竜介, 美藤 純弘

    　 More details

    Grant amount：\4290000 （ Direct expense: \3300000 、 Indirect expense：\990000 ）

    researchmap

  • single cell RNA-seqによるうま味細胞における新規機能分子探索

    2022.01 - 2024.12

    うま味研究会  うま味研究会助成金 

    　 More details

    Authorship：Principal investigator  Grant type：Competitive

    Grant amount：\1000000 （ Direct expense: \1000000 ）

    researchmap

  • Analysis of taste function in oral-brain-gut axis using new photogenetical tool

    Grant number：21K19601  2021.07 - 2024.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Exploratory)

    吉田 竜介, 古株 彰一郎, 高尾 知佳

    　 More details

    Grant amount：\6370000 （ Direct expense: \4900000 、 Indirect expense：\1470000 ）

    本年度は、野生型マウスおよび全身で甘味受容体コンポーネントを欠損するT1R3-KOマウスを用い、グルコースを口腔から摂取した場合と胃内投与した場合の血糖値および血中インスリン濃度の経時的変化（０～１２０分）について調べた。マウスをリック装置から溶液を摂取する様トレーニングし、グルコース摂取量が1mg/g体重となるよう2Mグルコースを摂取させた場合（口腔摂取）と同量を直接胃内投与した場合とを比較すると、血糖値のピークはいずれのマウスにおいても口腔摂取した方が早く（およそ摂取後１０分）、胃内投与した場合には遅くなっていた（およそ摂取後３０分）。血漿インスリン濃度についても同様の差が見られた。この結果から、口腔からグルコースを摂取した場合には頭相インスリン分泌が見られ、これがグルコース摂取後の血糖値変化を影響を与えるものと考えられる。また、甘味受容体T1R2/T1R3を介さない口腔からの何らかの感覚情報が重要であると考えられる。
    また、光KOマウス作成について、開発済みのTet offシステムにより光活性化-Cre（PA-Cre）発現を制御するTRE-PA-Creマウスと、全身的にテトラサイクリン調節性トランス活性化因子（tTA）を発現するROSA-tTAマウスを開発し掛け合わせ、全身でPA-Creを発現するマウス（PA-Cre）を作成する予定であったが、ROSA-tTAマウスを取得することが出来なかったため、全身性PA-Creマウスはまだ作成できていない。

    researchmap

  • The raison d'etre of classical synapses in taste buds

    Grant number：21H03106  2021.04 - 2025.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    吉田 竜介, 美藤 純弘, 樽野 陽幸, 池亀 美華

    　 More details

    Grant amount：\17420000 （ Direct expense: \13400000 、 Indirect expense：\4020000 ）

    本年度は、本研究で用いる以下の遺伝子改変マウスを作成した。(1)味蕾においてGABA合成酵素であるGAD67を欠損するマウス（K5-Cre;GAD67-flox）、(2)味蕾においてGABA合成酵素であるGAD67を欠損しGFPを発現するマウス（K5-Cre;GAD67-GFP/flox）、(3)味蕾においてシナプス関連遺伝子SNAP25を欠損するマウス（K5-Cre;SNAP25-flox）、(4)味蕾内でIII型細胞のみで発現する遺伝子を欠損するマウス２種（TypeIII-A-KO、TypeIII-B-KO）。今後、(3)または(4)かつGAD67-GFPを発現するマウス、(1)～(4)かつTRPV1を欠損するマウスを順次作成する予定である。また、K5-Creの味蕾での発現を確認するため、GAD67-GFPを発現し、K5発現細胞でtomatoの発現を誘導するマウス（K5-Cre;ROSA26-tomato;GAD67-GFP）を作成し、GAD67発現細胞（III型細胞）を含む味蕾細胞でK5-Creが発現することを確認した。さらに免疫組織化学的実験により、(2)のマウスにおいて味蕾内GFP発現細胞でGAD67発現が消失し、他の味細胞マーカー遺伝子の発現は変化しないことを確認した。
    次に、これらマウスを作成するために用いた各種遺伝子改変マウス（K5-Cre、GAD67-flox、SNAP25-flox、TRPV1-KO）の味覚行動応答について短時間リック法にて調べた。その結果、これらのマウスは各種味溶液（ショ糖、キニーネ、NaCl、グルタミン酸ナトリウム、HCl、クエン酸など）に対し野生型マウスとほぼ同様の応答を示すことを確認した。ただし、TRPV1-KOマウスに関してはカプサイシンに対する忌避反応が減弱していた。

    researchmap

  • 食品由来成分の味覚を介した全身機能に対する影響

    2021.04 - 2024.05

    糧食研究会  特定委託研究 

    　 More details

    Authorship：Principal investigator 

    researchmap

  • Elucidation of nutrient-specific taste cell-neuron matching mechanism

    Grant number：18K19652  2018.06 - 2021.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)  Grant-in-Aid for Challenging Research (Exploratory)

    Shigemura Noriatsu

    　 More details

    Grant amount：\6370000 （ Direct expense: \4900000 、 Indirect expense：\1470000 ）

    Taste quality specific information (taste discrimination) is constantly maintained, despite lifespan of taste cells is as short as about 10 days. This suggests there would be a molecular mechanisms that newborn taste cells are selectively matched with distinct taste neurons during continuous turnover. However, little is known about such taste cell-neuron matching mechanisms. In this study, to clarify this, we focused on the cell adheasion protein, Cadherin (Cdh) super-family, and examined its involvement in the matching mechanisms. Expresssion analyses including GeneChip revealed that protocadherin 20 was expressed specifically in both sweet taste cells and taste neurons, which may contribute to cell-neuron matching to generate the sweet taste infomation line.

    researchmap

  • Development of new technology for taste cell omics: exploring molecular logics of high calorie sensing and taste signal transduction

    Grant number：18K19653  2018.06 - 2020.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)  Grant-in-Aid for Challenging Research (Exploratory)

    Ninomiya Yuzo

    　 More details

    Grant amount：\6240000 （ Direct expense: \4800000 、 Indirect expense：\1440000 ）

    The present study predicted fat taste- and calorie sensing-related molecules based on comprehensive gene analysis of mouse single taste cells, and made functional analyses on their expression in taste cells and potential relations to taste nerve and behavioral responses to various taste stimuli. The results showed that, in addition to known taste information pathways for each of 5 basic tastes (sweet, sour, salt, bitter and umami), there exist two different taste neural pathways for fat perception: one is a fat taste-specific pathway derived from cells expressing fat receptors such as GPR120 etc, and the other is a calorie sensing pathway derived from cells co-expressing multiple transporters and receptors for lipids and sugars, and metabolic sensor channels (KATP). Thus, the new taste cell omics technology, which is a fusion of taste cell comprehensive gene analysis and taste response analysis, has led to the new findings and its effectiveness was suggested.

    researchmap

  • Molecular and cellular mechanisms for modulation of sweet taste sensitivity

    Grant number：18K09507  2018.04 - 2021.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Yoshida Ryusuke

    　 More details

    Grant amount：\4290000 （ Direct expense: \3300000 、 Indirect expense：\990000 ）

    This study demonstrated that (1) sweet-sensitive taste cells (T1R3-expressing taste cells) possess leptin signaling components (STAT3, SHP2, PI3K), (2) among these components, PI3K plays a critical role in suppression of sweet responses of taste cells by leptin, and (3) leptin-induced activation of PI3K leads to production of PIP3 and phosphorylation of Akt in T1R3-expressing taste cells.

    researchmap

  • Molecular physiological basis of modulation and repair by oxidative stress in oral/gut/ brain chemosensory-endocrine interaction for dietary regulation.

    Grant number：18H02968  2018.04 - 2021.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)  Grant-in-Aid for Scientific Research (B)

    Ninomiya Yuzo

    　 More details

    Grant amount：\17290000 （ Direct expense: \13300000 、 Indirect expense：\3990000 ）

    Leptin and angiotensin II are hormones that regulate eating and drinking cravings in the brain, and sweet and salt taste sensitivities in the peripheral taste organ and contribute to energy and Na+ homeostasis. Also, the hormones at high concentrations are known to act as oxidative stress inducers in their target organs. This study investigated potential effects of oxidative stress on taste cells and target molecules based on analyses of mouse neural and behavioral taste responses and molecular expression. The results showed that oxidative stress agents increased sweet responses and decreased sodium responses and their targets of oxidative stress may be at intracellular region of KATP (sweet taste) known as a leptin target, and at extracellular region of ENaCs (sodium taste) known as an angiotensin II target.

    researchmap

  • Molecular basis of taste perception and humoral modulation of taste/hormone sensing cells in the oral-gut-brain circuit and its role in regulating food intake

    Grant number：15H02571  2015.04 - 2018.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)  Grant-in-Aid for Scientific Research (A)

    NINOMIYA YUZO, Yasumatsu Keiko, Takai Shingo

    　 More details

    Grant amount：\40820000 （ Direct expense: \31400000 、 Indirect expense：\9420000 ）

    The present study investigated molecular basis of taste perception and humoral modulation of taste/hormone sensing cells in the oral-gut-brain circuit and its role in regulating food intake. The results showed that mouse sweet-sensitive cells in the oral cavity and gut possess at least two sweet reception systems; one is T1R2/T1R3 which can detect not only sugars but also artificial sweeteners and the other is T1Rs-independent sugar sensing system including glucose transporters (SGLTs/GLUTs), a metabolic sensor(KATP) and GLP-1, gut peptide hormone. In addition to GLP-1 for sweet signal transmission, CCK was shown be involved in bitter signal transmission in bitter-responsive cells. Leptin, a satiety hormone, inhibits sweet taste responses and glucose absorption via activation of KATP involved in the sugar sensing pathway of sweet-sensitive cells. This taste modulation by leptin may be involved in regulating energy homeostasis, of which the abnormality may possibly lead to the obesity.

    researchmap

  • Coding of bitter taste information among taste bud cells

    Grant number：26462815  2014.04 - 2017.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Yoshida Ryusuke

    　 More details

    Grant amount：\4810000 （ Direct expense: \3700000 、 Indirect expense：\1110000 ）

    This study has demonstrated that (1) Bitter sensitive taste cells are heterogeneous from the point of view of their responsiveness, (2) Overall response profile of bitter taste cells to multiple bitter compounds was not significantly different between fungiform and circumvallate papillae, (3) Bitter responses of taste cells were significantly suppressed by TRPM5 inhibitor and PLC inhibitor, (4) Bitter responses of mouse taste cells were not affected by human bitter receptor antagonists, (5) CCK may be involved in peripheral bitter taste signaling. These data help understanding receptors and transduction mechanisms for bitter taste and give insights into coding of bitter taste information in the peripheral taste system.

    researchmap

  • Molecular and neural mechanisms for detection, modulation and transmission of taste signal for fat preference

    Grant number：26670810  2014.04 - 2016.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research  Grant-in-Aid for Challenging Exploratory Research

    Ninomiya Yuzo, Shigemura Noriatsu, Yoshida Ryusuke

    　 More details

    Grant amount：\3510000 （ Direct expense: \2700000 、 Indirect expense：\810000 ）

    The present study investigated molecular and neural mechanisms of detection, modulation and transmission of taste signals for fat preference. The results showed that there exists selective neural pathway for fatty acids in mice, that some of taste fibers best responding to sweet, umami or Ca are also sensitive to fatty acids, and that sweet-suppressive effect by leptin in diet-induced obese mice decreases with increasing circulating leptin which in turn reciprocally increase sweet-enhancing effect by endocannabinoids (eCBs). In another aspect, repeated stimulation with mixture of sugar and fatty acids gradually increase taste responses to the mixture. This enhancement of responses by repeated stimulations was abolished by eCB receptor blockage, suggesting involvement of eCB in the enhancement. Collectively, taste enhancement of sugar by mixing fatty acids may lead to behavioral preference for the mixture, thereby potential facilitation of development of obesity.

    researchmap

  • The roles of GABA on development and function of taste bud cells

    Grant number：23689076  2011.04 - 2014.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A)  Grant-in-Aid for Young Scientists (A)

    YOSHIDA Ryusuke

    　 More details

    Grant amount：\23530000 （ Direct expense: \18100000 、 Indirect expense：\5430000 ）

    This study has demonstrated that (1) GABA may not have a pivotal role in development of taste buds or taste cells and in innervation of gustatory nerve fibers to taste buds, (2) GABA may be released from a subset of taste cells, possibly Type III cells, by depolarization of these cells, (3) intracellular Cl- concentration in taste cells may be very high therefore GABA would induce excitatory responses in these taste cells. These results suggest that GABA may play some roles in modulation of taste sensitivities in taste buds.

    researchmap

  • Reception, transduction, and modulation of sweet taste in taste receptor cells : Analysis by using transgenic mice.

    Grant number：21791808  2009 - 2010

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    YOSHIDA Ryusuke

    　 More details

    Grant amount：\4160000 （ Direct expense: \3200000 、 Indirect expense：\960000 ）

    This study has revealed (1) Endocannabinoids selectively enhance sweet taste via CB1 receptor on sweet sensitive taste cells, (2) Taste cells expressing T1R3, a sweet and umami taste receptor component, that are identified by using T1R3-GFP mice respond to various sweet and/or umami taste stimuli, (3) T1R3-GFP taste cells lacking T1R3, gustducin, or TRPM5 do not respond to taste stimuli, (4) T1R3-GFP taste cells express Gα11, 14, s, q, and i2 as Gα subunits other than gustducin.

    researchmap

  • Discrimination of taste information among taste bud cells

    Grant number：19791367  2007 - 2008

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    YOSHIDA Ryusuke

    　 More details

    Grant amount：\3680000 （ Direct expense: \3200000 、 Indirect expense：\480000 ）

    本研究では、(1)5基本味(甘・苦・塩・酸・うま味)のうち、甘味、苦味、うま味を受容する味細胞と酸味を受容する味細胞の細胞型が異なること、
    (2)塩味受容細胞はアミロライド感受性により2つのタイプが存在すること、
    (3)うま味の受容細胞には甘味とうま味を受容する味細胞、うま味特異的味細胞が存在し、それぞれにうま味相乗効果の有無により更に2つのタイプに分類されることを明らかにした。これらは味情報が味細胞レベルで分別されている可能性を示唆する。

    researchmap

  • Alteration of cell response and behavior by temporal, special, phylogenetic modal-shifts of taste cell sensors.

    Grant number：18077004  2006 - 2010

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Priority Areas  Grant-in-Aid for Scientific Research on Priority Areas

    NINOMIYA Yuzo, SHIGEMURA Noriatsu, YOSHIDA Ryusuke

    　 More details

    Grant amount：\64400000 （ Direct expense: \64400000 ）

    Potential modal-shifts of sensitivities of taste cell sensors were studied by examining cellular and behavior responses to sweet and salty stimuli under various molecular and environmental conditions. The results suggest that as comparable with the action of central nervous system, endocannabinoids, orexigenic mediators, enhanced peripheral sweet taste sensitivities, that opposes the action of leptin, an anorexigenic mediator. Species-specific sweet-suppressing effect of gurmarin occurs its binding to the mouse extracellular domain of T1r3(partially that of T1r2). In addition, molecular based modal-shift was found in sodium-salt sensor ENaC channels where an amino acid change (R616W) in αsubunit may produce variation in amiloride-sensitivity of the channel.

    researchmap

  • Taste Signaling Mechanisms for the Regulation of Food Intake: Approaches to Establishment for Taste Health Science

    Grant number：18109013  2006 - 2010

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (S)  Grant-in-Aid for Scientific Research (S)

    NINOMIYA Yuzo, SHIGEMURA Noriatsu, YOSHIDA Ryusuke, SANEMATSU KEISUKE

    　 More details

    Grant amount：\112450000 （ Direct expense: \86500000 、 Indirect expense：\25950000 ）

    Reception and modulation of taste signals and their roles in the regulation of food intake are investigated by examining taste cell, nerve and behavioral responses to various taste compounds. The results showed that sweet taste signal is initiated from a particular group of taste cells expressing T1r2/T1r3 sweet receptors and is transmitted to its corresponding group of nerve fibers through ATP release. Sweet taste sensitivity is inhibited by leptin, a satiety hormone, of which plasma level has a diurnal variation. Sweet taste thresholds also show diurnal variation that is parallel with that of plasma leptin levels. This synchronization, however, is not evident in obese subjects. Analyses on single nucleotide polymorphisms of umami receptor genes indicate existence of multiple receptors in umami perception in humans. These results provide new findings in the taste receptor and transduction mechanisms and new insights for potential roles of peripheral taste signal in the control for food intake, of which abnormality may possibly lead to the obesity.

    researchmap

  • 味細胞の生理機能と発現分子との連関:シングルセルRT-PCR法による解析

    Grant number：17791325  2005 - 2006

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    吉田 竜介

    　 More details

    Grant amount：\3300000 （ Direct expense: \3300000 ）

    本研究は、マウスの舌上皮・味蕾標本を用いることにより味覚受容器の構築を大きく損なうことなく細胞の生存性を高め、ルーズパッチ法により味細胞の味刺激に対する応答を記録し、その細胞における発現遺伝子をマルチプレックス・シングルセルRT-PCR法により検索することにより、受容体などの味覚関連分子の味細胞での発現と味細胞の応答特性との関連を解析することを目的とする。
    マウス茸状乳頭味細胞のNaCl応答をルーズパッチ法で解析した結果、およそ半数の細胞が上皮性ナトリウムチャネル(ENaC)の阻害剤であるアミロライドに感受性があり(AS細胞)、残り半数はアミロライドに感受性を示さなかった(Al細胞)。AS細胞はNaClに特異的な応答を示し、Al細胞はNaCl以外にも電解質溶液(KCI、HCIなど)に応答を示した。アミロライドの効果は味孔側に与えられた場合に限られ、基底外側膜側に与えた場合には効果がなかった。これらの味細胞の応答特性や存在比は、鼓索神経にみられる2つのタイプ(アミロライド感受性のNタイプと非感受性のEタイプ)の線維のそれらと一致することが示唆された。シングルセルRT-PCRにより、これらの細胞でのENaCの発現を調べたところ、AS細胞ではα-ENaCの発現が検出され、Al細胞ではENaCサブユニットの発現は検出できなかったことから、AS細胞ではENaCがNaCl応答に関与している可能性が示唆される。
    また、味細胞のグルタミン酸(MSG)応答を解析した結果、MSG応答細胞はサッカリンに応答する細胞、NaClに応答する細胞、MSGのみに応答する細胞に大別された。これらの応答特性の違いと、発現遺伝子との関連性については、現在の所、まだ明らかにはできていない。

    researchmap

▼display all

 

Class subject in charge

  • Regulatory science （2024academic year） Fourth semester  - 月1～3,金1～3

  • Human Physiology （2024academic year） Concentration  - その他

  • Physiology of animal function （2024academic year） 1st semester  - 水1,水2,水3

  • Medical law ethics and social welfare （2024academic year） special  - その他

  • Oral functions in health （2024academic year） 1st semester  - 木3～4

  • Inquiry about organs constituting mouth （2024academic year） Third semester  - 火5～6

  • Emerging Sciences for Oral Care, Eating & Swallowing, and Nutrition （2024academic year） special  - その他

  • Emerging Sciences for Oral Care, Eating & Swallowing, and Nutrition （2024academic year） special  - その他

  • Research Presentation in Oral Functional Reconstruction （2024academic year） special  - その他

  • Oral Physiology （2024academic year） Third semester  - 水1～3,木4

  • Practicals: Oral Physiology （2024academic year） special  - その他

  • Exercise for oral functions （2024academic year） Third semester  - 木5,木6,木7

  • Research Projects: Oral Physiology （2024academic year） special  - その他

  • Research Projects and Practicals:Oral Physiology I （2024academic year） special  - その他

  • Lecture and Research Projects:Oral Physiology I （2024academic year） special  - その他

  • Research Projects and Practicals: Oral Physiology II （2024academic year） special  - その他

  • Lecture and Research Projects:Oral Physiology II （2024academic year） special  - その他

  • Physiology of vegetative function （2024academic year） Second semester  - 水1,水2,水3

  • Exercise for dental health care （2024academic year） 1st and 2nd semester  - 火1～3

  • Practice in dental sciences （2024academic year） special  - その他

  • Diet and nutrition （2024academic year） Second semester  - 金3～4

  • Human Physiology （2023academic year） Concentration  - その他

  • Physiology of animal function （2023academic year） 1st semester  - 水1,水2,水3

  • Oral functions in health （2023academic year） 1st semester  - 木3～4

  • Inquiry about organs constituting mouth （2023academic year） Third semester  - 火5～6

  • Emerging Sciences for Oral Care, Eating & Swallowing, and Nutrition （2023academic year） special  - その他

  • Emerging Sciences for Oral Care, Eating & Swallowing, and Nutrition （2023academic year） special  - その他

  • Research Presentation in Oral Functional Reconstruction （2023academic year） special  - その他

  • Oral Physiology （2023academic year） Third semester  - 水1～3,木4

  • Practicals: Oral Physiology （2023academic year） special  - その他

  • Exercise for oral functions （2023academic year） Third semester  - 木5,木6,木7

  • Research Projects: Oral Physiology （2023academic year） special  - その他

  • Research Projects and Practicals:Oral Physiology I （2023academic year） special  - その他

  • Lecture and Research Projects:Oral Physiology I （2023academic year） special  - その他

  • Research Projects and Practicals: Oral Physiology II （2023academic year） special  - その他

  • Lecture and Research Projects:Oral Physiology II （2023academic year） special  - その他

  • Venture adventure with multidiscipline （2023academic year） Fourth semester  - 月3～4

  • Physiology of vegetative function （2023academic year） Second semester  - 水1,水2,水3

  • Exercise for dental health care （2023academic year） 1st and 2nd semester  - 火1～3

  • Final digest of dental sciences （2023academic year） 1st semester  - 火1,火2,火3

  • Final digest of dental sciences （2023academic year） Second semester  - 月3,火3,水3,金1～2

  • Diet and nutrition （2023academic year） Second semester  - 金3～4

  • Human Physiology （2022academic year） Concentration  - その他

  • Physiology of animal function （2022academic year） 1st semester  - 水1,水2,水3

  • Oral functions in health （2022academic year） 1st semester  - 木3～4

  • Research Presentation in Oral Functional Reconstruction （2022academic year） special  - その他

  • Oral Physiology （2022academic year） Third semester  - 水1～3,木4

  • Exercise for oral functions （2022academic year） Third semester  - 木5,木6,木7

  • Research Projects and Practicals:Oral Physiology I （2022academic year） special  - その他

  • Lecture and Research Projects:Oral Physiology I （2022academic year） special  - その他

  • Research Projects and Practicals: Oral Physiology II （2022academic year） special  - その他

  • Lecture and Research Projects:Oral Physiology II （2022academic year） special  - その他

  • Physiology of vegetative function （2022academic year） Second semester  - 水1,水2,水3

  • Final digest of dental sciences （2022academic year） 1st semester  - 火1,火2,火3

  • Final digest of dental sciences （2022academic year） Second semester  - 月3,火3,水3,金1～2

  • Diet and nutrition （2022academic year） Second semester  - 金3～4

  • Human Physiology （2021academic year） Concentration  - その他

  • Physiology of animal function （2021academic year） 1st semester  - 水1,水2,水3

  • Research Presentation in Oral Functional Reconstruction （2021academic year） special  - その他

  • Oral Physiology （2021academic year） Third semester  - 水1～3,木4

  • Exercise for oral functions （2021academic year） Third semester  - 木5,木6,木7

  • Research Projects and Practicals:Oral Physiology I （2021academic year） special  - その他

  • Lecture and Research Projects:Oral Physiology I （2021academic year） special  - その他

  • Research Projects and Practicals: Oral Physiology II （2021academic year） special  - その他

  • Lecture and Research Projects:Oral Physiology II （2021academic year） special  - その他

  • Physiology of vegetative function （2021academic year） Second semester  - 水1,水2,水3

  • Final digest of dental sciences （2021academic year） 1st semester  - 火1,火2,火3

  • Final digest of dental sciences （2021academic year） Second semester  - 月3,火3,水3,金1～2

  • Physiology of animal function （2020academic year） 1st semester  - 水1,水2,水3

  • Research Presentation in Oral Functional Reconstruction （2020academic year） Year-round  - その他

  • Oral Functional Reconstruction （2020academic year） Year-round  - その他

  • Oral Physiology （2020academic year） Third semester  - 水1～3,木4

  • Exercise for oral functions （2020academic year） Third semester  - 木5,木6,木7

  • Research Projects and Practicals:Oral Physiology I （2020academic year） special  - その他

  • Lecture and Research Projects:Oral Physiology I （2020academic year） special  - その他

  • Research Projects and Practicals: Oral Physiology II （2020academic year） special  - その他

  • Lecture and Research Projects:Oral Physiology II （2020academic year） special  - その他

  • Physiology of vegetative function （2020academic year） Second semester  - 水1,水2,水3

  • Physiology of animal function （2019academic year） 1st semester  - 水1,水2,水3

  • Research Presentation in Oral Functional Reconstruction （2019academic year） Year-round  - その他

  • Oral Functional Reconstruction （2019academic year） Year-round  - その他

  • Oral Physiology （2019academic year） Third semester  - 水1～3,木4

  • Exercise for oral functions （2019academic year） Third semester  - 木5,木6,木7

  • Research Projects and Practicals:Oral Physiology I （2019academic year） special  - その他

  • Lecture and Research Projects:Oral Physiology I （2019academic year） special  - その他

  • Research Projects and Practicals: Oral Physiology II （2019academic year） special  - その他

  • Lecture and Research Projects:Oral Physiology II （2019academic year） special  - その他

  • Physiology of vegetative function （2019academic year） Second semester  - 水1,水2,水3

  • Oral Physiology （2018academic year） Third semester  - 水1～3,木4

  • Exercise for oral functions （2018academic year） Third semester  - 木5,木6,木7

▼display all

 

Social Activities

  • 市民講座：味と匂から見つめる食

    Role(s)：Presenter,　Organizing member

    岡山大学学術研究院医歯薬学域口腔生理学/日本味と匂学会  2024.9.13

    　More details

    Type：Lecture

    researchmap

  • 苦いコーヒーなぜ飲めるように？ 味の感じ方変わるよ

    Role(s)：Media coverage

    日本経済新聞  2024.6.22

    　More details

    Type：Newspaper, magazine

    researchmap

  • 出張講師

    Role(s)：Lecturer

    津山高等学校  2024.6.21

    　More details

  • 味覚で体は守れるか？

    Role(s)：Lecturer

    岡山大学  岡山大学医歯薬学総合研究科・大学院保健学研究科 公開講座「岡山健康講座2022―やさしい保健と健康の話―」  2022.10.3 - 2022.10.31

    　More details

    Type：Lecture

    researchmap

  • 出張講義

    Role(s)：Lecturer

    津山高等学校  2019.6.21

    　More details

    Type：Visiting lecture

    researchmap

  • 末梢味覚器におけるうま味のコーディング

    Role(s)：Lecturer

    うま味研究会  うま味研究会 公開シンポジウム  2019.6.7

    　More details

    Type：Lecture

    researchmap

  • 味覚の不思議 ～口だけではないその機能～

    Role(s)：Lecturer

    岡山大学研究推進機構  第72回岡大サイエンスカフェ  2019.5.16

    　More details

    Type：Science cafe

    researchmap

▼display all

Media Coverage

  • 天神ワイド・朝

    RSK山陽放送  2025.1.13

    　More details

  • 教えて！専門家の皆さん！！美味しいものを作るために知っておくべき「味覚」について

    日仏商事株式会社  パン職人とパティシエのための情報サイトChefno  2023.6.13

    　More details

Academic Activities

  • The 21st International Symposium on Molecular and Neural mechanisms of Taste and Olfactory Perception

    Role(s)：Planning, management, etc.

    Ryusuke Yoshida  2025.3.1 - 2025.3.2

    　More details

    Type：Competition, symposium, etc. 

    researchmap

  • 日本味と匂学会第５８回大会

    Role(s)：Planning, management, etc.

    吉田竜介  2024.9.11 - 2024.9.13

    　More details

    Type：Academic society, research group, etc. 

    researchmap

  • The 20th International Symposium on Molecular and Neural mechanisms of Taste and Olfactory Perception

    Role(s)：Planning, management, etc.

    Yuzo Ninomiya, Ryusuke Yoshida  2023.11.25 - 2023.11.26

    　More details

    Type：Competition, symposium, etc. 

    researchmap

  • The 19th International Symposium on Molecular and Neural mechanisms of Taste and Olfactory Perception

    Role(s)：Planning, management, etc.

    Yuzo Ninomiya, Ryusuke Yoshida  2023.3.18 - 2023.3.19

    　More details

    Type：Competition, symposium, etc. 

    researchmap