研究者詳細 - 國定　勇希

論文 - 國定　勇希

分割表示 49 件中 1 - 20 件目／全件表示 >>

The trochlea for the intermediate tendon of the digastric muscle: a review

Xander du Plooy, Yuki Kunisada, Juan J. Cardona, Yoko Tabira, Kathleen Carol Bubb, Kazzara Raeburn, Soichiro Ibaragi, Joe Iwanaga, R. Shane Tubbs

Anatomy & Cell Biology 2025年6月

The maxillary vein: an anatomical narrative review with clinical implications for oral and maxillofacial surgeons

Kazzara Raeburn, Yohei Takeshita, Hiroaki Takakura, Shogo Kikuta, Yuki Kunisada, Soichiro Ibaragi, Rarinthorn Samrid, Marios Loukas, R. Shane Tubbs, Joe Iwanaga

Anatomy & Cell Biology 2025年6月

The greater palatine nerve and artery both supply the maxillary teeth

Joe Iwanaga, Yohei Takeshita, Muralidharan Anbalagan, Binghao Zou, Taku Toriumi, Yuki Kunisada, Soichiro Ibaragi, R. Shane Tubbs

The Journal of the American Dental Association 2025年2月

Lingual nerve revisited-A comprehensive review Part II: Surgery and radiology. 国際誌

Kisho Ono, Takashi Nishioka, Kyoichi Obata, Yohei Takeshita, Chista Irani, Yuki Kunisada, Norie Yoshioka, Soichiro Ibaragi, R Shane Tubbs, Joe Iwanaga

Clinical anatomy (New York, N.Y.) 2024年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

The lingual nerve (LN) is a branch of the mandibular division of the fifth cranial nerve, the trigeminal nerve, arising in the infratemporal fossa. It provides sensory fibers to the mucous membranes of the floor of the mouth, the lingual gingiva, and the anterior two-thirds of the tongue. Although the LN should rarely be encountered during routine and basic oral surgical procedures in daily dental practice, its anatomical location occasionally poses the risk of iatrogenic injury. The purpose of this section is to consider this potential LN injury risk and to educate readers about the anatomy of this nerve and how to treat it.

DOI： 10.1002/ca.24211

PubMed

researchmap

Lingual nerve revisited-A comprehensive review Part I: Anatomy and variations. 国際誌

Norio Kitagawa, Keiko Fukino, Chista Irani, Yushi Abe, Yuki Kunisada, Soichiro Ibaragi, R Shane Tubbs, Joe Iwanaga

Clinical anatomy (New York, N.Y.) 2024年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

The lingual nerve (LN) is a branch of the mandibular division of the fifth cranial nerve, the trigeminal. It primarily carries sensory fibers from the lingual gingiva, mucous membranes of the floor of the mouth, sublingual gland, and the anterior two-thirds of the tongue. Recent studies have explored and reclassified the five branches of the LN as branches to the isthmus of the fauces, lingual branches, sublingual nerves, posterior branch to the submandibular ganglion, and branches to the sublingual ganglion. The knowledge of the LN anatomy and its variants is clinically relevant to avoid its injury during oral procedures. The objective of this paper is to review the literature on the LN and to describe the anatomy, its course, and its functions.

DOI： 10.1002/ca.24210

PubMed

researchmap

Spontaneous Eruption of Permanent Teeth That Had Eruption Disturbances After Extirpation of Odontomas: A Report of Two Cases 国際誌

Yuki Kunisada, Norie Yoshioka, Kyoichi Obata, Koki Umemori, Soichiro Ibaragi

Cureus 16 ( 5 ) e61460 2024年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

Odontomas, often found adjacent to impacted teeth, are tumors of abnormal tissue morphology arising from the tooth germ and are usually asymptomatic. They are often found by accident on X-ray images, and the eruption of permanent teeth is often caused by odontomas. In most cases, the tooth is extracted with the permanent tooth or orthodontic treatment is performed after extraction. However, the criteria are not clear. We encountered two cases of dental eruption in which permanent teeth, which originally seemed to be suitable for orthodontic treatment, spontaneously erupted after odontoma removal. It is necessary to examine the indications and timing of tooth extraction.

DOI： 10.7759/cureus.61460

PubMed

researchmap

上顎癒合不全の自然治癒を認めたLe Fort I型骨切り術後Floating Maxillaの2症例

西山明慶, 國定勇希, 竜門省二, 小野喜章, 吉岡徳枝, 伊原木聰一郎

日本顎変形症学会雑誌 34 ( 2 ) 167 - 167 2024年5月

細胞外小胞と銅輸送経路調節を介した頭頸部癌におけるシスプラチン耐性機序の解明

小川辰雄, 小野喜章, 小畑協一, 國定勇希, 奥井達雄, 伊原木聰一郎

頭頸部癌 50 ( 2 ) 159 - 159 2024年5月

美容整形目的に使用されたヒアルロン酸によりオトガイ部の骨吸収をきたした顎変形症の2例

吉岡徳枝, 西山明慶, 國定勇希, 坂本裕美, 小野喜章, 小畑協一

日本口腔診断学会雑誌 37 ( 1 ) 85 - 85 2024年2月

Terrein Exhibits Anti-tumor Activity by Suppressing Angiogenin Expression in Malignant Melanoma Cells. 国際誌

Taira Hirose, Yuki Kunisada, Koichi Kadoya, Hiroki Mandai, Yumi Sakamoto, Kyoichi Obata, Kisho Ono, Hiroaki Takakura, Kazuhiro Omori, Shogo Takashiba, Seiji Suga, Soichiro Ibaragi

Cancer genomics & proteomics 21 ( 5 ) 464 - 473 2024年

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND/AIM: Malignant melanoma is a tumor with a poor prognosis that can metastasize distally at an early stage. Terrein, a metabolite produced by Aspergillus terreus, suppresses the expression of angiogenin, an angiogenic factor. However, the pharmacological effects of natural terrein have not been elucidated, because only a small amount of terrein can be extracted from large fungal cultures. In this study, we investigated the antineoplastic effects of terrein on human malignant melanoma cells and its underlying mechanisms. MATERIALS AND METHODS: Human malignant melanoma cell lines were cultured in the presence of terrein and analyzed. Angiogenin production was evaluated using ELISA. Ribosome biosynthesis was evaluated using silver staining of the nucleolar organizer region. Intracellular signaling pathways were analyzed using western blotting. Malignant melanoma cells were transplanted subcutaneously into the backs of nude mice. The tumors were removed at 5 weeks and analyzed histopathologically. RESULTS: Terrein inhibited angiogenin expression, proliferation, migration, invasion, and ribosome biosynthesis in malignant melanoma cells. Terrein was shown to inhibit tumor growth and angiogenesis in animal models. CONCLUSION: This study demonstrated that terrein has anti-tumor effects against malignant melanoma. Furthermore, chemically synthesized non-natural terrein can be mass-produced and serve as a novel potential anti-tumor drug candidate.

DOI： 10.21873/cgp.20464

PubMed

researchmap

A Rare Case of Multiple Myeloma Identified Following the Diagnosis of Amyloidosis of the Tongue. 国際誌

Hideka Kanemoto, Kyoichi Obata, Koichi Kadoya, Kisho Ono, Hotaka Kawai, Yuki Kunisada, Mayumi Yao, Soichiro Ibaragi

Case reports in dentistry 2024 8836103 - 8836103 2024年

記述言語：英語掲載種別：研究論文（学術雑誌）

Amyloidosis is a disease in which amyloid protein is deposited in organs and tissues, resulting in functional impairment. Amyloidosis occurs in 12%-30% of patients with multiple myeloma, but in rare cases, amyloidosis may precede the diagnosis of multiple myeloma. Our patient was a 76-year-old Japanese male on dialysis. Multiple nodules accompanied by ulcers were observed on his tongue. He had no subjective symptoms or clinical findings associated with multiple myeloma. The histopathological findings suggested amyloidosis. We suspected both systemic and localized amyloidosis and performed a comprehensive systemic examination. Since the patient had been on dialysis for only a short period of time (~3 months), dialysis-related amyloidosis was ruled out. After blood and urine tests, a diagnosis of multiple myeloma was made. Chemotherapy treatment was started, but the patient's multiple myeloma could not be suppressed and the tongue amyloidosis worsened, leading to his death 2 years and 2 months after the initial diagnosis.

DOI： 10.1155/2024/8836103

PubMed

researchmap

A pancreatic cancer mouse model with human immunity. 国際誌

Norio Miyamura, Kodai Suzuki, Richard A Friedman, Aristidis Floratos, Yuki Kunisada, Kazuya Masuda, Andrew M Lowy, Moriya Tsuji, Kazuki N Sugahara

bioRxiv : the preprint server for biology 2023年5月

記述言語：英語

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a tumor immune microenvironment (TIME) that promotes resistance to immunotherapy. A preclinical model system that facilitates studies of the TIME and its impact on the responsiveness of human PDAC to immunotherapies remains an unmet need. We report a novel mouse model, which develops metastatic human PDAC that becomes infiltrated by human immune cells recapitulating the TIME of human PDAC. The model may serve as a versatile platform to study the nature of human PDAC TIME and its response to various treatments.

DOI： 10.1101/2023.05.24.542127

PubMed

researchmap

Tumor-resident regulatory T cells in pancreatic cancer express the αvβ5 integrin as a targetable activation marker. 国際誌

Kodai Suzuki, Yuki Kunisada, Norio Miyamura, Shingo Eikawa, Tatiana Hurtado de Mendoza, Evangeline S Mose, Caisheng Lu, Yukihito Kuroda, Erkki Ruoslahti, Andrew M Lowy, Kazuki N Sugahara

bioRxiv : the preprint server for biology 2023年5月

記述言語：英語

Pancreatic ductal adenocarcinoma (PDAC) has abundant immunosuppressive regulatory T cells (Tregs), which contribute to a microenvironment resistant to immunotherapy. Here, we report that Tregs in the PDAC tissue, but not those in the spleen, express the αvβ5 integrin in addition to neuropilin-1 (NRP-1), which makes them susceptible to the iRGD tumor-penetrating peptide, which targets cells positive for αv integrin- and NRP-1. As a result, long-term treatment of PDAC mice with iRGD leads to tumor-specific depletion of Tregs and improved efficacy of immune checkpoint blockade. αvβ5 integrin + Tregs are induced from both naïve CD4 + T cells and natural Tregs upon T cell receptor stimulation, and represent a highly immunosuppressive subpopulation of CCR8 + Tregs. This study identifies the αvβ5 integrin as a marker for activated tumor-resident Tregs, which can be targeted to achieve tumor-specific Treg depletion and thereby augment anti-tumor immunity for PDAC therapy.

DOI： 10.1101/2023.05.24.542137

PubMed

researchmap

Craniomaxillofacial Fibrous Dysplasia Improved Cosmetic and Occlusal Problem by Comprehensive Treatment: A Case Report and Review of Current Treatments. 国際誌

Kisho Ono, Norie Yoshioka, Yuki Kunisada, Tomoya Nakamura, Yuko Nakamura, Kyoichi Obata, Soichiro Ibaragi, Shogo Minagi, Akira Sasaki

Diagnostics (Basel, Switzerland) 12 ( 9 ) 2022年9月

記述言語：英語

Fibrous dysplasia (FD) is a fibrous lesion of immature bone, with an incidence of 10-20% in the head and neck region. Most cases are monostotic, but when a lesion occurs on the maxillofacial region and spreads to the surrounding bone, it is classified as polyostotic, despite its localized occurrence. In some cases, surgical intervention is required to improve the cosmetic or functional disturbance of a FD in the maxillofacial region, but it is necessary to confirm symmetry of the maxillofacial region in real time, and a surgical support system is required to compensate. Furthermore, prosthetic intervention is considered when postoperative acquired defects occur or further cosmetic or occlusal function improvement is needed. A comprehensive approach by an oral surgeon and a maxillofacial prosthodontist is necessary for the successful treatment and rehabilitation of such patients. In this article, we describe the case of a craniomaxillofacial FD patient with facial asymmetry and denture incompatibility with improved quality of life measures by integrating surgical treatment using a navigation system and postoperative prosthetic rehabilitation. We also discuss recent diagnostic methods and treatment strategies for craniomaxillofacial FD in the literature.

DOI： 10.3390/diagnostics12092146

PubMed

researchmap

口腔癌の化学療法中に発症した肺血栓塞栓症の1例

柴田茜, 志茂剛, 岸本晃治, 國定勇希, 目瀬浩, 佐々木朗

日本口腔外科学会雑誌 68 ( 4 ) 193 - 200 2022年4月

Reproduction of the Antitumor Effect of Cisplatin and Cetuximab Using a Three-dimensional Spheroid Model in Oral Cancer. 国際誌

Kisho Ono, Kohei Sato, Tomoya Nakamura, Yume Yoshida, Shogo Murata, Kunihiro Yoshida, Hideka Kanemoto, Koki Umemori, Hotaka Kawai, Kyoichi Obata, Shoji Ryumon, Kazuaki Hasegawa, Yuki Kunisada, Tatsuo Okui, Soichiro Ibaragi, Hitoshi Nagatsuka, Akira Sasaki

International journal of medical sciences 19 ( 8 ) 1320 - 1333 2022年

記述言語：英語掲載種別：研究論文（学術雑誌）

Background/Aim: Cancer research has been conducted using cultured cells as part of drug discovery testing, but conventional two-dimensional culture methods are unable to reflect the complex tumor microenvironment. On the other hand, three-dimensional cultures have recently been attracting attention as in vitro models that more closely resemble the in vivo physiological environment. The purpose of this study was to establish a 3D culture method for oral cancer and to verify its practicality. Materials and Methods: Three-dimensional cultures were performed using several oral cancer cell lines. Western blotting was used for protein expression analysis of the collected cell masses (spheroids), and H-E staining was used for structural observation. The cultures were exposed to cisplatin and cetuximab and the morphological changes of spheroids over time and the expression changes of target proteins were compared. Results: Each cell line formed spheroidal cell aggregates and showed enhancement of cell adhesion molecules over time. H-E staining showed tumor tissue-like structures specific to each cell line. Cisplatin showed concentration-dependent antitumor effects due to loss of cell adhesion and spheroid disruption in each cell line, while cetuximab exhibited antitumor effects that correlated with EGFR expression in each cell line. Conclusion: Spheroids made from oral cancer cell lines appeared to have tumor-like characteristics that may reflect their clinical significance. In the future, it may become possible to produce tumor spheroids from tissue samples of oral cancer patients, and then apply them to drug screening and to develop individualized diagnostic and treatment methods.

DOI： 10.7150/ijms.74109

PubMed

researchmap

Displacement of lower third molar into floor of mouth: a single institutional experience. 国際誌

Masanori Masui, Soichiro Ibaragi, Yohei Takeshita, Joe Iwanaga, Yuki Kunisada, Akira Sasaki

Oral and maxillofacial surgery 26 ( 3 ) 447 - 453 2021年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

PURPOSE: The displacement of the tooth/tooth fragment into the floor of mouth sometimes happens during the lower third molar surgery and the patients are usually referred to oral and maxillofacial surgeons. To date, however, there is no consensus how to manage the displaced tooth due to the lack of available data. METHODS: In this study, we have retrospectively analyzed the management of the displaced lower third molar into the floor of mouth. Our institute experienced seven cases during 2010 to 2020. RESULTS: Incidence rate of the lingual nerve injury caused by displacement of the lower third molar was 1/7. Six patients out of seven underwent surgical removal of the displaced fragment. The direct approach was used when the fragment was palpable superficially and the fragment was horizontally located away from the lingual plate (2 cases), while when the fragment was not palpable, or was palpable and adjacent to the lingual plate, the lingual mucoperiosteal flap was selected (4 cases). CONCLUSION: We conclude that the palpation and preoperative diagnosis with computed tomographic images are significantly important to decide a better and most effective surgical approach.

DOI： 10.1007/s10006-021-01012-3

PubMed

researchmap

High mobility group box 1は口腔扁平上皮癌の骨破壊を誘発する

坂本裕美, 奥井達雄, 竜門省二, 中村友哉, 國定勇希, 増井正典, 小野喜章, 小畑協一, 伊原木聰一郎, 佐々木朗

日本口腔科学会雑誌 70 ( 2 ) 115 - 115 2021年7月

Expression of Neurokinin B Receptor in the Gingival Squamous Cell Carcinoma Bone Microenvironment. 国際誌

Shoko Yoshida, Tsuyoshi Shimo, Kiyofumi Takabatake, Yurika Murase, Kyoichi Obata, Tatsuo Okui, Yuki Kunisada, Soichiro Ibaragi, Hitoshi Nagatsuka, Akira Sasaki

Diagnostics (Basel, Switzerland) 11 ( 6 ) 2021年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

Gingival squamous cell carcinoma (SCC) frequently invades the maxillary or mandibular bone, and bone destruction is known as a key prognostic factor in gingival SCCs. Recently, Neurokinin 3 receptor (NK-3R), the receptor ligand for NK-3, which is a member of the tachykinin family expressed in the central nervous system, was identified through pathway analysis as a molecule expressed in osteoclasts induced by the hedgehog signal. Although the expression of NK-3R has been detected in osteoclast and SCC cells at the bone invasion front, the relationship between NK-3R expression and the prognosis of gingival SCC patients remains unclear. In the present study, we retrospectively reviewed 27 patients with gingival SCC who had undergone surgery with curative intent. Significantly higher NK-3R expression in tumor cells was found in a case of jawbone invasion than in a case of exophytic poor jawbone invasion. On the other hand, no significant association was observed between NK-3R tumor-positive cases and tumor size, TNM stage, or tumor differentiation. The survival rate tended to be lower in NK-3R tumor-positive cases, but not significantly. However, the disease-specific survival rate was significantly lower in patients with a large number of NK-3R-positive osteoclasts than in those with a small number of them at the tumor bone invasion front. Our results suggest that NK-3R signaling in the gingival SCC bone microenvironment plays an important role in tumor bone destruction and should be considered a potential therapeutic target in advanced gingival SCC with bone destruction.

DOI： 10.3390/diagnostics11061044

PubMed

researchmap

A case of langerhans cell histiocytosis of the mandible that spontaneously regressed after biopsy in a child 国際誌

Kisho Ono, Tatsuo Okui, Yuki Kunisada, Kyoichi Obata, Masanori Masui, Shoji Ryumon, Soichiro Ibaragi, Tomoya Nakamura, Akira Sasaki

Clinical Case Reports 9 ( 6 ) e04321 2021年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Wiley

In younger patients of LCH, we should consider that the effectiveness of follow-up without aggressive treatment for SS-type LCH in the oral and maxillofacial bone. However, there are very rare case in which an SS-type LCH recurred after showing a healing tendency. Regular follow-up must be performed even after healing.

DOI： 10.1002/ccr3.4321

PubMed

researchmap

その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ccr3.4321

　前のページ - 次のページ　

<國定 勇希>

論文 - 國定 勇希

<國定　勇希>

論文 - 國定　勇希