Updated on 2025/04/02

写真a

 
KUNISADA Yuki
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Associate Professor
Position
Associate Professor
Other name(s)
岡山大学
External link

Degree

  • 博士(歯学) ( 岡山大学 )

Research Interests

  • 腫瘍免疫

  • 制御性T細胞

  • DDS

Research Areas

  • Life Science / Oral pathobiological science

  • Life Science / Surgical dentistry

  • Life Science / Tumor diagnostics and therapeutics  / がん免疫学

  • Life Science / Immunology

Education

  • Okayama University   大学院医歯薬学総合研究科  

    2012.4 - 2016.3

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    Country: Japan

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  • Okayama University   歯学部   歯学科

    2004.4 - 2011.3

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    Country: Japan

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Research History

  • Okayama University   学術研究院 医歯薬学域 口腔顎顔面外科学   Assistant Professor

    2023.4

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    Country:Japan

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  • Columbia University   Surgery   Associate Research Scientist

    2021.7 - 2023.3

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    Country:United States

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  • Okayama University   Graduate School of Medicine , Dentistry and Pharmaceutical Sciences   Assistant Professor

    2019.4 - 2021.7

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    Country:Japan

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  • Okayama University   Graduate School of Medicine , Dentistry and Pharmaceutical Sciences

    2019.3

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  • Okayama University   Dental School

    2021.7 - 2023.3

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Professional Memberships

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Papers

  • The greater palatine nerve and artery both supply the maxillary teeth

    Joe Iwanaga, Yohei Takeshita, Muralidharan Anbalagan, Binghao Zou, Taku Toriumi, Yuki Kunisada, Soichiro Ibaragi, R. Shane Tubbs

    The Journal of the American Dental Association   2025.2

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.adaj.2024.11.012

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  • The trochlea for the intermediate tendon of the digastric muscle: a review

    Xander du Plooy, Yuki Kunisada, Juan J. Cardona, Yoko Tabira, Kathleen Carol Bubb, Kazzara Raeburn, Soichiro Ibaragi, Joe Iwanaga, R. Shane Tubbs

    Anatomy & Cell Biology   2025.1

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.5115/acb.24.178

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  • Lingual nerve revisited-A comprehensive review Part II: Surgery and radiology. International journal

    Kisho Ono, Takashi Nishioka, Kyoichi Obata, Yohei Takeshita, Chista Irani, Yuki Kunisada, Norie Yoshioka, Soichiro Ibaragi, R Shane Tubbs, Joe Iwanaga

    Clinical anatomy (New York, N.Y.)   2024.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    The lingual nerve (LN) is a branch of the mandibular division of the fifth cranial nerve, the trigeminal nerve, arising in the infratemporal fossa. It provides sensory fibers to the mucous membranes of the floor of the mouth, the lingual gingiva, and the anterior two-thirds of the tongue. Although the LN should rarely be encountered during routine and basic oral surgical procedures in daily dental practice, its anatomical location occasionally poses the risk of iatrogenic injury. The purpose of this section is to consider this potential LN injury risk and to educate readers about the anatomy of this nerve and how to treat it.

    DOI: 10.1002/ca.24211

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  • Lingual nerve revisited-A comprehensive review Part I: Anatomy and variations. International journal

    Norio Kitagawa, Keiko Fukino, Chista Irani, Yushi Abe, Yuki Kunisada, Soichiro Ibaragi, R Shane Tubbs, Joe Iwanaga

    Clinical anatomy (New York, N.Y.)   2024.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    The lingual nerve (LN) is a branch of the mandibular division of the fifth cranial nerve, the trigeminal. It primarily carries sensory fibers from the lingual gingiva, mucous membranes of the floor of the mouth, sublingual gland, and the anterior two-thirds of the tongue. Recent studies have explored and reclassified the five branches of the LN as branches to the isthmus of the fauces, lingual branches, sublingual nerves, posterior branch to the submandibular ganglion, and branches to the sublingual ganglion. The knowledge of the LN anatomy and its variants is clinically relevant to avoid its injury during oral procedures. The objective of this paper is to review the literature on the LN and to describe the anatomy, its course, and its functions.

    DOI: 10.1002/ca.24210

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  • Spontaneous Eruption of Permanent Teeth That Had Eruption Disturbances After Extirpation of Odontomas: A Report of Two Cases International journal

    Yuki Kunisada, Norie Yoshioka, Kyoichi Obata, Koki Umemori, Soichiro Ibaragi

    Cureus   16 ( 5 )   e61460   2024.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Odontomas, often found adjacent to impacted teeth, are tumors of abnormal tissue morphology arising from the tooth germ and are usually asymptomatic. They are often found by accident on X-ray images, and the eruption of permanent teeth is often caused by odontomas. In most cases, the tooth is extracted with the permanent tooth or orthodontic treatment is performed after extraction. However, the criteria are not clear. We encountered two cases of dental eruption in which permanent teeth, which originally seemed to be suitable for orthodontic treatment, spontaneously erupted after odontoma removal. It is necessary to examine the indications and timing of tooth extraction.

    DOI: 10.7759/cureus.61460

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MISC

  • 口腔外科受診を契機に診断・治療に至った舌咽神経痛の1例

    木村 拓紀, 小野 喜章, 福嶋 輝保, 小畑 協一, 國定 勇希, 伊原木 聰一郎

    日本口腔科学会雑誌   72 ( 4 )   254 - 254   2023.12

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    Language:Japanese   Publisher:(NPO)日本口腔科学会  

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  • 舌下面に発生した神経鞘腫の1例

    福嶋 輝保, 小野 喜章, 山本 和泉, 小畑 協一, 國定 勇希, 柚鳥 宏和, 伊原木 聰一郎

    日本口腔科学会雑誌   72 ( 4 )   255 - 255   2023.12

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    Language:Japanese   Publisher:(NPO)日本口腔科学会  

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  • 上顎前歯部歯肉に発生した周辺性石灰化歯原性嚢胞の1例

    山本 和泉, 小畑 協一, 矢尾 真弓, 福嶋 輝保, 小野 喜章, 國定 勇希, 伊原木 聰一郎

    日本口腔科学会雑誌   72 ( 4 )   256 - 256   2023.12

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    Language:Japanese   Publisher:(NPO)日本口腔科学会  

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  • Le Fort I型骨切り術と片側SSRO,分割オトガイ形成術で治療した第一第二鰓弓症候群による顔面非対称の1例

    西山 明慶, 小畑 協一, 國定 勇希, 竜門 省二, 小野 喜章, 吉岡 徳枝, 伊原木 聰一郎

    日本顎変形症学会雑誌   33 ( 2 )   180 - 180   2023.5

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    Language:Japanese   Publisher:(NPO)日本顎変形症学会  

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  • 当科における顎矯正手術症例の臨床統計的観察

    西山 明慶, 吉岡 徳枝, 國定 勇希, 小畑 協一, 増井 正典, 小野 喜章, 竜門 省二, 伊原木 聰一郎, 佐々木 朗

    日本顎変形症学会雑誌   32 ( 2 )   222 - 222   2022.5

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    Language:Japanese   Publisher:(NPO)日本顎変形症学会  

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Presentations

  • 細胞外小胞と銅輸送経路調節を介した頭頸部癌におけるシスプラチン耐性機序の解明

    小川 辰雄, 小野 喜章, 小畑 協一, 國定 勇希, 奥井 達雄, 伊原木 聰一郎

    頭頸部癌  2024.5  (一社)日本頭頸部癌学会

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    Event date: 2024.5

    Language:Japanese  

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  • 上顎癒合不全の自然治癒を認めたLe Fort I型骨切り術後Floating Maxillaの2症例

    西山 明慶, 國定 勇希, 竜門 省二, 小野 喜章, 吉岡 徳枝, 伊原木 聰一郎

    日本顎変形症学会雑誌  2024.5  (NPO)日本顎変形症学会

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    Event date: 2024.5

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  • 上顎前歯部歯肉に発生した周辺性石灰化歯原性嚢胞の1例

    山本 和泉, 小畑 協一, 矢尾 真弓, 福嶋 輝保, 小野 喜章, 國定 勇希, 伊原木 聰一郎

    日本口腔科学会雑誌  2023.12  (NPO)日本口腔科学会

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    Event date: 2023.12

    Language:Japanese  

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  • 舌下面に発生した神経鞘腫の1例

    福嶋 輝保, 小野 喜章, 山本 和泉, 小畑 協一, 國定 勇希, 柚鳥 宏和, 伊原木 聰一郎

    日本口腔科学会雑誌  2023.12  (NPO)日本口腔科学会

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    Event date: 2023.12

    Language:Japanese  

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  • 口腔外科受診を契機に診断・治療に至った舌咽神経痛の1例

    木村 拓紀, 小野 喜章, 福嶋 輝保, 小畑 協一, 國定 勇希, 伊原木 聰一郎

    日本口腔科学会雑誌  2023.12  (NPO)日本口腔科学会

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    Event date: 2023.12

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Awards

  • 第72回NPO法人日本口腔科学会学術集会 優秀ポスター賞

    2018   NPO法人日本口腔科学会   2型糖尿病薬メトホルミンによる腫瘍局所の制御性T細胞抑制による抗腫瘍効果

    國定勇希

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Research Projects

  • To elucidate the mechanism of inhibition of Treg induction by tumor penetrating peptide iRGD.

    Grant number:24K12897  2024.04 - 2028.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    國定 勇希, 河合 穂高

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    Grant amount:\4550000 ( Direct expense: \3500000 、 Indirect expense:\1050000 )

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  • 脂質代謝を標的とした新規免疫抑制解除型治療の基盤研究

    Grant number:19K16836  2019.04 - 2022.03

    日本学術振興会  科学研究費助成事業 若手研究  若手研究

    國定 勇希

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    Grant amount:\3900000 ( Direct expense: \3000000 、 Indirect expense:\900000 )

    1. 蛍光免疫組織染色によるstage毎のがん細胞における脂肪酸合成と免疫細胞の相関関係の解析では口腔がん患者の組織切片で脂肪酸合成剤FASN(Fatty acid synthase)分子,Treg, CD8T細胞,CD4T細胞などの免疫細胞を多重蛍光免疫組織染色し,現在も症例数を増やして継続して解析中である.同実験では,腫瘍組織内に浸潤しているTregやCD8を可視化して,また同時に脂肪酸合成阻害剤との関連も検出出来ている.
    2. 脂肪酸合成阻害剤の直接的ながん細胞への作用の解析では脂肪酸合成阻害剤(スタチン)の存在下,非存在下で,ヒト口腔がん細胞株(SAS,HSC2,3)やマウスがん細胞株(SCC7)を培養し,脂肪酸合成阻害が直接的にが ん細胞の増殖能や浸潤能に影響するかどうかをin vitroの培養系で解析を行っている.がん細胞をシャーレで培養し,数の変化を経時的に観察し,増殖能の評価 を行い,transwell invasion assayを用いて浸潤能の評価を行っている.さらに,脂肪酸合成阻害剤(スタチン)の濃度を振り,マウスがん細胞株(SCC7)を培養し,フローサイトメーターを用いて細胞周期に変化があるかどうかの解析を行っている.
    3. マウス腫瘍移植モデルを用いた脂肪酸合成阻害剤による末梢あるいは腫瘍局所におけ るTregの数の変化,機能の変化の解析ではマウスがん細胞株をC57BL/6マウス背部皮内に移植し,脂肪酸合成阻害剤を使用して抗腫瘍効果があるか解析を試みた.

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  • The study of the regulatory mechanisms of cancer bone destruction metabolism and immunity in Hedgehog signaling

    Grant number:18H02999  2018.04 - 2022.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    SHIMO Tsuyoshi

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    Grant amount:\17160000 ( Direct expense: \13200000 、 Indirect expense:\3960000 )

    Hedgehog downstream signaling molecules deployed from a comprehensive pathway analysis in the cancer bone destruction microenvironment (Shimo et al. PlosOne 2016) are associated with prognosis in gingival cancer patients with Stage IV jaw bone invasion (Yoshida, Shimo et al. Diagnostics (Basel) 2021).
    In addition, tumor vascular endothelial cells in patients with Stage II introverted tongue cancer showed significantly enhanced expression of Hedgehog signaling and a positive correlation with tumor-associated macrophage (TAM) accumulation (Takabatake, Shimo et al. Int J Mol Sci 2019). We also analyzed the histological and genetical effect of Gli-1 and Gli-2 dual inhibitor on the in vitro study and in vivo cancer bone destruction mouse model.

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  • Regulation of function and antitumor effect of regulatory T cells in the tumor microenvironment by metformine, a type 2 diabetes drug

    Grant number:17K15025  2017.04 - 2019.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    Kunisada Yuki, UDONO Heiichiro, EIKAWA Shingo

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    Grant amount:\4420000 ( Direct expense: \3400000 、 Indirect expense:\1020000 )

    We have already demonstrated that the type 2 diabetes drug metformin has antitumor activity via immune cells. In this study, we analyzed the effect of metformin on immunoregulatory regulatory T cells (Tregs), which are said to contribute to tumor growth.
    In the mouse tumor transplantation model, we observed that administration of metformin induced Treg apoptosis and suppressed Treg function in only tumor local sites. In addition, we demonstrated that the metabolism of Treg, which metabolism is dominant in fatty acid oxidation, is predominantly changed from fatty acid oxidation to glycolytic metabolism at the time of differentiation / induction from non-Treg cells to Treg.

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  • Antitumor effect of anti-CCR4 antibody in head and neck cancer

    Grant number:26463042  2014.04 - 2017.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    DOMAE Shohei, KUNISADA Yuki, TAKAKURA Hiroaki

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    Grant amount:\4810000 ( Direct expense: \3700000 、 Indirect expense:\1110000 )

    CCR4 expressing FoxP3+CD4 regulatory T cells (Treg) depletion using humanized anti-CCR4 monoclonal antibodies may enhance the host immune response against tumors. The current ongoing clinical trial investigates the use of humanized anti-human-CCR4 monoclonal antibody in the treatment of solid tumors. CCR4 expressing stroma infiltrating lymphocytes were detected in 32 of 42 (76.2%) head and neck cancer samples and were correlate with CCL22/MDC. CCR4 expressing tumor cells were detected in only 7 of 42 (16.7%) same samples. There was no markedly enhancement of antitumor effect by anti-CCR4 antibody in CCR4 expressing tumor cells.

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Class subject in charge

  • Management of Systemic Diseases for Oral Surgery, blood disorder (2020academic year) Third semester  - 金1