Updated on 2024/03/24

写真a

 
SUGIMOTO Seiichiro
 
Organization
Okayama University Hospital Associate Professor
Position
Associate Professor
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Degree

  • MD, PhD ( 2007.3   Okayama University )

Research Interests

  • 呼吸器外科

  • 呼吸生理

  • Lung transplantation

  • Precision medicine

  • Lung cancer

  • Ischemia reperfusion injury

  • Chronic lung allograft dysfunction

  • Lung allograft rejection

  • 手術手技

Research Areas

  • Life Science / Respiratory surgery

Education

  • Okayama University   大学院医歯学総合研究科   病態制御科学早期修了

    2004.4 - 2007.3

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    Country: Japan

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Research History

  • 岡山大学病院   准教授

    2020.4

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    Country:Japan

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  • 岡山大学病院   講師

    2019.4 - 2020.3

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    Country:Japan

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  • 岡山大学病院   助教

    2012.9 - 2019.3

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    Country:Japan

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  • 岡山大学病院   助教

    2011.3 - 2012.9

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    Country:Japan

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  • 岡山大学病院   医員

    2009.7 - 2011.2

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    Country:Japan

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  • セントルイス・ワシントン大学医学部   研究員

    2007.4 - 2009.6

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    Country:United States

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Professional Memberships

  • アメリカ胸部外科学会(AATS)

    2024

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  • 日本呼吸器外科学会 編集委員会委員

    2023

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  • 日本移植学会代議員

    2023

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  • 日本移植学会 レシピエント移植コーディネーター認定合同委員会委員

    2022

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  • 日本呼吸器外科学会 国際委員会委員

    2021 - 2023

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  • 日本臓器移植ネットワーク メディカルコンサルタント

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  • 日本臨床外科学会 評議員

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  • 日本胸部外科学会 専門医会員

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  • 日本呼吸器外科学会 評議員

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  • 日本肺癌学会 中国・四国支部評議員

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  • 日本呼吸器内視鏡学会 気管支鏡専門医・指導医

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  • The International Society for Heart and Lung Transplantation

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  • 日本移植学会 移植認定医

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  • 肺癌CT検診認定医師

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  • 日本がん治療認定医機構 がん治療認定医

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  • 日本呼吸器学会 呼吸器専門医・指導医

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  • 日本外科学会認定医・専門医・指導医

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  • 呼吸器外科専門医

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  • 日本医学教育学会

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  • 関西胸部外科学会 評議員

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  • 胸腔鏡安全技術認定医

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  • ロボット支援手術プロクター

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  • 日本呼吸器学会中国四国支部代議員

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Papers

  • Impact of the neutrophil-to-lymphocyte ratio on patients with locally advanced non-small cell lung cancer who suffer radiation pneumonitis during the course of induction chemoradiotherapy followed by surgery.

    Yujiro Kubo, Hiromasa Yamamoto, Kei Matsubara, Kohei Hashimoto, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, Kuniaki Katsui, Takao Hiraki, Katsuyuki Kiura, Shinichi Toyooka

    Surgery today   2024.3

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    PURPOSE: Radiation pneumonitis (RP) is an obstacle for patients after surgery following induction chemoradiotherapy for locally advanced non-small cell lung cancer (LA-NSCLC). We performed a comparative analysis of the association between clinicopathological factors, including the neutrophil-to-lymphocyte ratio (NLR) and prognosis, in LA-NSCLC patients with or without RP during induction chemoradiotherapy followed by surgery. METHODS: The subjects of this analysis were 168 patients undergoing trimodality therapy for LA-NSCLC between January, 1999 and May, 2019. Patients were divided into two groups: the RP group (n = 41) and the non-RP group (n = 127). We compared the clinicopathological factors including the NLR between the groups and analyzed the association between the NLR and prognosis. RESULTS: The RP group had more patients with tumors located in the lower lobe, more bilobar resections, shorter operative times, no implementation of postoperative adjuvant chemotherapy, and a higher postoperative NLR than the non-RP group. There were no significant differences in serious postoperative complications and the prognosis. Patients with a low postoperative NLR had a significantly better prognosis in the non-RP group, and a trend toward a better prognosis even in the RP group. CONCLUSION: Postoperative NLR may be a useful prognostic factor, even for patients who suffer RP after trimodality therapy for LA-NSCLC.

    DOI: 10.1007/s00595-024-02816-y

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  • Plasma concentrations of histidine-rich glycoprotein in primary graft dysfunction after lung transplantation. International journal

    Toshio Shiotani, Seiichiro Sugimoto, Yasuaki Tomioka, Shin Tanaka, Toshiharu Mitsuhashi, Ken Suzawa, Kazuhiko Shien, Kentaroh Miyoshi, Hiromasa Yamamoto, Mikio Okazaki, Shinichi Toyooka

    Interdisciplinary cardiovascular and thoracic surgery   2024.2

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    OBJECTIVES: Histidine-rich glycoprotein has been reported as an anti-inflammatory glycoprotein that inhibits acute lung injury in mice with sepsis and as a prognostic biomarker in patients with sepsis. We investigated the relationship between plasma concentrations of histidine-rich glycoprotein and the risk of occurrence of primary graft dysfunction. METHODS: According to the primary graft dysfunction grade at post-transplant 72 hours, patients who underwent lung transplantation were divided into three groups: non-primary graft dysfunction group (grade 0-1), moderate primary graft dysfunction group (grade 2), and severe primary graft dysfunction group (grade 3). The plasma concentrations of histidine-rich glycoprotein measured daily during the first post-transplant 7 days were compared among the three groups. Appropriate cutoff values of the concentrations were set for survival analyses after lung transplantation. RESULTS: A total of 68 patients were included. The plasma histidine-rich glycoprotein concentration at post-transplant 72 hours was significantly lower in the severe primary graft dysfunction group (n = 7) than in the other two groups (non-primary graft dysfunction group (n = 43), P = 0.042; moderate primary graft dysfunction group (n = 18), P = 0.040). Patients with plasma histidine-rich glycoprotein concentration ≥34.4 µg/mL at post-transplant 72 hours had significantly better chronic lung allograft dysfunction-free survival (P = 0.012) and overall survival (P = 0.037) than those with the concentration <34.4 µg/mL. CONCLUSIONS: Plasma histidine-rich glycoprotein concentrations at post-transplant 72 hours might be associated with the risk of development of primary graft dysfunction.

    DOI: 10.1093/icvts/ivae021

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  • Long-term outcomes of lung transplantation requiring renal replacement therapy: A single-center experience. International journal

    Yasuaki Tomioka, Seiichiro Sugimoto, Toshio Shiotani, Kei Matsubara, Haruki Choshi, Megumi Ishihara, Shin Tanaka, Kentaroh Miyoshi, Shinji Otani, Shinichi Toyooka

    Respiratory investigation   62 ( 2 )   240 - 246   2024.1

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    BACKGROUND: Life-long immunosuppressive therapy after lung transplantation (LT) may lead to end-stage renal disease (ESRD), requiring renal replacement therapy (RRT). We aimed to investigate the characteristics and long-term outcomes of patients undergoing LT and requiring RRT. METHODS: This study was a single-center, retrospective cohort study. The patients were divided into the RRT (n = 15) and non-RRT (n = 170) groups. We summarized the clinical features of patients in the RRT group and compared patient characteristics, overall survival, and chronic lung allograft dysfunction (CLAD)-free survival between the two groups. RESULTS: The cumulative incidences of ESRD requiring RRT after LT at 5, 10, and 15 years were 0.8 %, 7.6 %, and 25.2 %, respectively. In the RRT group, all 15 patients underwent hemodialysis but not peritoneal dialysis, and two patients underwent living-donor kidney transplantation. The median follow-up period was longer in the RRT group than in the non-RRT group (P < 0.001). The CLAD-free survival and overall survival did not differ between the two groups. The 5-year survival rate even after the initiation of hemodialysis was 53.3 %, and the leading cause of death in the RRT group was infection. CONCLUSIONS: Favorable long-term outcomes can be achieved by RRT for ESRD after LT.

    DOI: 10.1016/j.resinv.2024.01.001

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  • Successful Living-donor Lobar Lung Transplantation With BK Virus-related Hemorrhagic Cystitis Throughout the Perioperative Period. International journal

    Yasuaki Tomioka, Shinji Otani, Shin Tanaka, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    Transplantation direct   10 ( 1 )   e1556   2024.1

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    DOI: 10.1097/TXD.0000000000001556

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  • Corrigendum: Use of the index of pulmonary vascular disease for predicting longterm outcome of pulmonary arterial hypertension associated with congenital heart disease. International journal

    Ayako Chida-Nagai, Naoki Masaki, Kay Maeda, Konosuke Sasaki, Hiroki Sato, Jun Muneuchi, Yoshie Ochiai, Hiroomi Murayama, Masahiro Tahara, Atsuko Shiono, Atsushi Shinozuka, Fumihiko Kono, Daisuke Machida, Shinichi Toyooka, Seiichiro Sugimoto, Kazufumi Nakamura, Satoshi Akagi, Maiko Kondo, Shingo Kasahara, Yasuhiro Kotani, Junichi Koizumi, Katsuhiko Oda, Masako Harada, Daisuke Nakajima, Akira Murata, Hazumu Nagata, Koichi Yatsunami, Tomio Kobayashi, Yoshikiyo Matsunaga, Takahiro Inoue, Hiroyuki Yamagishi, Naomi Nakagawa, Katsuki Ohtani, Masaki Yamamoto, Yushi Ito, Tatsunori Hokosaki, Yuta Kuwahara, Satoshi Masutani, Koji Nomura, Tsutomu Wada, Hirofumi Sawada, Masayuki Abiko, Tatsunori Takahashi, Yuichi Ishikawa, Seigo Okada, Atsushi Naitoh, Takako Toda, Tatsuya Ando, Akihiro Masuzawa, Shinsuke Hoshino, Masaaki Kawada, Yuichi Nomura, Kentaro Ueno, Naoki Ohashi, Tsuyoshi Tachibana, Yuchen Cao, Hideaki Ueda, Sadamitsu Yanagi, Masaaki Koide, Norie Mitsushita, Kouji Higashi, Yoshihiro Minosaki, Tomohiro Hayashi, Takashi Okamoto, Kenji Kuraishi, Eiji Ehara, Hidekazu Ishida, Hitoshi Horigome, Takashi Murakami, Kohta Takei, Taku Ishii, Gen Harada, Yasutaka Hirata, Jun Maeda, Shunsuke Tatebe, Chiharu Ota, Yasunobu Hayabuchi, Hisanori Sakazaki, Takashi Sasaki, Keiichi Hirono, Sayo Suzuki, Masahiro Yasuda, Atsuhito Takeda, Madoka Sawada, Kagami Miyaji, Atsushi Kitagawa, Yosuke Nakai, Nobuyuki Kakimoto, Kouta Agematsu, Atsushi Manabe, Yoshikatsu Saiki

    Frontiers in cardiovascular medicine   11   1369831 - 1369831   2024

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    [This corrects the article DOI: 10.3389/fcvm.2023.1212882.].

    DOI: 10.3389/fcvm.2024.1369831

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  • Correction to: Periostin secreted by cancer‑associated fibroblasts promotes cancer progression and drug resistance in non‑small cell lung cancer. International journal

    Fumiaki Takatsu, Ken Suzawa, Shuta Tomida, Yin Min Thu, Masakiyo Sakaguchi, Tomohiro Toji, Masayoshi Ohki, Shimpei Tsudaka, Keiichi Date, Naoki Matsuda, Kazuma Iwata, Yidan Zhu, Kentaro Nakata, Kazuhiko Shien, Hiromasa Yamamoto, Akiko Nakayama, Mikio Okazaki, Seiichiro Sugimoto, Shinichi Toyooka

    Journal of molecular medicine (Berlin, Germany)   2023.12

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  • Impact of changes in skeletal muscle mass and quality during the waiting time on outcomes of lung transplantation. International journal

    Akikazu Hagiyama, Seiichiro Sugimoto, Shin Tanaka, Kei Matsubara, Kentaroh Miyoshi, Yoshimi Katayama, Masanori Hamada, Masuo Senda, Shinichi Toyooka

    Clinical transplantation   e15169   2023.10

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    INTRODUCTION: The association of changes in skeletal muscle mass and quality during the waiting time with outcomes of lung transplantation (LT) remains unclear. We aimed to examine the association of changes in skeletal muscle mass and quality during the waiting time, as well as preoperative skeletal muscle mass and quality, with outcomes of LT. METHODS: This study included individuals who underwent LT from brain-dead donors. Skeletal muscle mass (cm2 /m2 ) and quality (mean Hounsfield units [HU]) of the erector spinae muscle at the 12th thoracic level were evaluated using computed tomography. Preoperative skeletal muscle mass and quality, and their changes during the waiting time were calculated. We evaluated the associations among mechanical ventilation (MV) duration, intensive care unit (ICU) length of stay (LOS), hospital LOS, 6-minute walk distance at discharge, and 5-year survival after LT. RESULTS: This study included 98 patients. The median waiting time was 594.5 days (interquartile range [IQR], 355.0-913.0). The median changes in skeletal muscle mass and quality were -4.4% (IQR, -13.3-3.1) and -2.9% (IQR, -16.0-4.1), respectively. Severe low skeletal muscle mass at LT was associated with prolonged ICU LOS (B = 8.46, 95% confidence interval [CI]: .51-16.42) and hospital LOS (B = 36.00, 95% CI: 3.23-68.78). Pronounced decrease in skeletal muscle mass during the waiting time was associated with prolonged MV duration (B = 7.85, 95% CI: .89-14.81) and ICU LOS (B = 7.97, 95% CI: .83-15.10). CONCLUSION: Maintaining or increasing skeletal muscle mass during the waiting time would be beneficial to improve the short-term outcomes of LT.

    DOI: 10.1111/ctr.15169

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  • In vivo lung perfusion for prompt recovery from primary graft dysfunction after lung transplantation. International journal

    Kei Matsubara, Kentaroh Miyoshi, Shinichi Kawana, Yujiro Kubo, Dai Shimizu, Yasuaki Tomioka, Toshio Shiotani, Haruchika Yamamoto, Shin Tanaka, Takeshi Kurosaki, Toshiaki Ohara, Mikio Okazaki, Seiichiro Sugimoto, Akihiro Matsukawa, Shinichi Toyooka

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation   2023.10

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    BACKGROUND: No proven treatment after the development of primary graft dysfunction (PGD) is currently available. Here we established a novel strategy of in vivo lung perfusion (IVLP) for the treatment of PGD. IVLP involves the application of an in vivo isolated perfusion circuit to an implanted lung. This study aimed to explore the effectiveness of IVLP versus conventional post-lung transplant (LTx) extracorporeal membrane oxygenation (ECMO) treatment using an experimental swine LTx PGD model. METHODS: After 1.5-h warm ischemia of the donor lungs, a left LTx was performed. Following the confirmation of PGD development, pigs were divided into three groups (n = 5 each): control (no intervention), ECMO, and IVLP. After 2 h of treatment, a 4-h functional assessment was conducted and samples obtained. RESULTS: Significantly better oxygenation were achieved in the IVLP group (p ≤ 0.001). Recovery was confirmed immediately and maintained during the following 4-h observation. The IVLP group also demonstrated better lung compliance than the control group (p = 0.045). A histological evaluation showed that the lung injury score and terminal deoxynucleotidyl transferase dUTP nick end labeling assay showed significantly fewer injuries and a better result in the wet-to-dry weight ratio in the IVLP group. CONCLUSIONS: A two-hour IVLP is technically feasible and allows for prompt recovery from PGD after LTx. The posttransplant short-duration IVLP strategy can complement or overcome the limitations of the current practice for donor assessment and PGD management.

    DOI: 10.1016/j.healun.2023.10.011

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  • Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer. International journal

    Fumiaki Takatsu, Ken Suzawa, Shuta Tomida, Yin Min Thu, Masakiyo Sakaguchi, Tomohiro Toji, Masayoshi Ohki, Shimpei Tsudaka, Keiichi Date, Naoki Matsuda, Kazuma Iwata, Yidan Zhu, Kentaro Nakata, Kazuhiko Shien, Hiromasa Yamamoto, Akiko Nakayama, Mikio Okazaki, Seiichiro Sugimoto, Shinichi Toyooka

    Journal of molecular medicine (Berlin, Germany)   2023.10

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    Cancer-associated fibroblasts (CAFs) are important components in the tumor microenvironment, and we sought to identify effective therapeutic targets in CAFs for non-small cell lung cancer (NSCLC). In this study, we established fibroblast cell lines from the cancerous and non-cancerous parts of surgical lung specimens from patients with NSCLC and evaluated the differences in behaviors towards NSCLC cells. RNA sequencing analysis was performed to investigate the differentially expressed genes between normal fibroblasts (NFs) and CAFs, and we identified that the expression of periostin (POSTN), which is known to be overexpressed in various solid tumors and promote cancer progression, was significantly higher in CAFs than in NFs. POSTN increased cell proliferation via NSCLC cells' ERK pathway activation and induced epithelial-mesenchymal transition (EMT), which improved migration in vitro. In addition, POSTN knockdown in CAFs suppressed these effects, and in vivo experiments demonstrated that the POSTN knockdown improved the sensitivity of EGFR-mutant NSCLC cells for osimertinib treatment. Collectively, our results showed that CAF-derived POSTN is involved in tumor growth, migration, EMT induction, and drug resistance in NSCLC. Targeting CAF-secreted POSTN could be a potential therapeutic strategy for NSCLC. KEY MESSAGES: • POSTN is significantly upregulated in CAFs compared to normal fibroblasts in NCSLC. • POSTN increases cell proliferation via activation of the NSCLC cells' ERK pathway. • POSTN induces EMT in NSCLC cells and improves the migration ability. • POSTN knockdown improves the sensitivity for osimertinib in EGFR-mutant NSCLC cells.

    DOI: 10.1007/s00109-023-02384-7

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  • Author Correction: Identification of genetic loci associated with renal dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array. International journal

    Yasuaki Tomioka, Seiichiro Sugimoto, Haruchika Yamamoto, Shuta Tomida, Toshio Shiotani, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Hiromasa Yamamoto, Mikio Okazaki, Masaomi Yamane, Shinichi Toyooka

    Scientific reports   13 ( 1 )   16721 - 16721   2023.10

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    DOI: 10.1038/s41598-023-43995-x

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  • Long-term management and outcome of lung transplantation in Japan. International journal

    Seiichiro Sugimoto, Kei Matsubara, Shin Tanaka, Kentaroh Miyoshi, Megumi Ishihara, Shinichi Toyooka

    Journal of thoracic disease   15 ( 9 )   5182 - 5194   2023.9

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    The long-term survival after lung transplantation (LT) is favorable in Japan. However, long-term survivors after LT are subject to late complications, including chronic lung allograft dysfunction (CLAD), malignancy, infection, and chronic kidney disease (CKD) because of the need for lifelong immunosuppression. The rates of single cadaveric LT (CLT) and living-donor lobar LT (LDLLT) are higher than that of bilateral CLT in Japan. Here, we will describe the management of late complications and long-term outcome after LT in Japan. Attention should be paid to not only the phenotype of CLAD but also the difference in CLAD after CLT and after LDLLT as well as the timing of lung re-transplantation for advanced CLAD, especially after single CLT. Since post-transplant lymphoproliferative disorder is the most common malignancy after LT, infection monitoring for infection-related malignancies and appropriate screening are keys to the early diagnosis and treatment of malignancy after LT. The long-term management of infection after LT is also important, especially with regard to community-acquired pathogens, Aspergillus, and cytomegalovirus. When providing long-term care after LT, physicians should be aware of CKD and the timing of renal replacement therapy in cases with severe CKD. The widespread use of computed tomography and dialysis in Japan are beneficial for long-term survivors of LT. The similar survival outcomes of single CLT and LDLLT, compared with bilateral CLT, might contribute to improved long-term survival in Japan. Pulmonologists are encouraged to become further involved in long-term management after LT in Japan.

    DOI: 10.21037/jtd-22-1679

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  • ASO Visual Abstract: Prognostic Impact of Tumor-Infiltrating Lymphocytes, Tertiary Lymphoid Structures, and Neutrophil-to-Lymphocyte Ratio in Pulmonary Metastases from Uterine Leiomyosarcoma. International journal

    Naoki Matsuda, Hiromasa Yamamoto, Tomohiro Habu, Kazuma Iwata, Kei Matsubara, Shin Tanaka, Kohei Hashimoto, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Tomohiro Toji, Mikio Okazaki, Seiichiro Sugimoto, Katsuhito Takahashi, Shinichi Toyooka

    Annals of surgical oncology   2023.9

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    DOI: 10.1245/s10434-023-14311-8

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  • Successful management of temporary veno-venous extracorporeal membrane oxygenation for a pediatric lung transplant recipient with bronchiolitis obliterans syndrome awaiting lung re-transplantation: a case report. International journal

    Yasuaki Tomioka, Kentaroh Miyoshi, Shin Tanaka, Seiichiro Sugimoto, Rie Kanai, Tetsuro Nikai, Shinichi Toyooka, Masaomi Yamane

    Surgical case reports   9 ( 1 )   163 - 163   2023.9

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    BACKGROUND: The use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation is an uncommon strategy in Japan owing to the severe donor shortage and absence of urgent allocation policy. Moreover, the use of veno-venous (VV) ECMO for immunosuppressed patients is controversial; thus, applying ECMO to patients who await lung re-transplantation is challenging. CASE PRESENTATION: A 16-year-old lung transplant recipient with grade 3 bronchiolitis obliterans syndrome was waitlisted for lung re-transplantation. Eleven months later, he fell into severe respiratory acidosis with hypercapnia, which were not resolved with mechanical ventilation. VV ECMO was introduced to minimize lung stress and strain. Tracheostomy was additionally performed on day 5 after the start of ECMO, and respiratory condition swiftly improved; hence, the weaning process from VV ECMO began on day 9. Rehabilitation became implementable, and bilateral re-lung transplantation was successfully performed 6 months after the ECMO treatment. No critical complication related to the precedent use of ECMO was noted. CONCLUSIONS: VV ECMO can be a feasible treatment option even for lung transplant candidates awaiting re-transplantation for a prolonged period. Introduction of ECMO and tracheostomy in the early deterioration stage may be crucial to successful subsequent patient management.

    DOI: 10.1186/s40792-023-01742-4

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  • Prognostic Impact of Tumor-Infiltrating Lymphocytes, Tertiary Lymphoid Structures, and Neutrophil-to-Lymphocyte Ratio in Pulmonary Metastases from Uterine Leiomyosarcoma. International journal

    Naoki Matsuda, Hiromasa Yamamoto, Tomohiro Habu, Kazuma Iwata, Kei Matsubara, Shin Tanaka, Kohei Hashimoto, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Tomohiro Toji, Mikio Okazaki, Seiichiro Sugimoto, Katsuhito Takahashi, Shinichi Toyooka

    Annals of surgical oncology   2023.9

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    BACKGROUND: The presence of tumor-infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLSs) in tumor tissue has been related to the prognosis in various malignancies. Meanwhile, neutrophil-to-lymphocyte ratio (NLR) as a systemic inflammation marker also has been associated with the prognosis in them. However, few reports have investigated the relationship between pulmonary metastases from sarcoma and these biomarkers. METHODS: We retrospectively recruited 102 patients undergoing metastasectomy for pulmonary metastases from uterine leiomyosarcoma at Okayama University Hospital from January 2006 to December 2019. TILs and TLSs were evaluated by immunohistochemical staining of surgically resected specimens of pulmonary metastases using anti-CD3/CD8/CD103/Foxp3/CD20 antibodies. NLR was calculated from the blood examination immediately before the most recent pulmonary metastasectomy. We elucidated the relationship between the prognosis and these factors. Because we considered that the status of tumor tissue and systemic inflammation were equally valuable, we also assessed the impact of the combination of TILs or TLSs and NLR on the prognosis. RESULTS: As for TILs, CD3-positive cells and CD8-positive cells were correlated with the prognosis. The prognosis was significantly better in patients with CD3-high group, CD8-high group, TLSs-high group, and NLR-low group, respectively. The prognosis of CD8-high/NLR-low group and TLSs-high/NLR-low group was significantly better than that of CD8-low/NLR-high group and TLSs-low/NLR-high group, respectively. CONCLUSIONS: CD3-positive TILs, CD8-positive TILs, TLSs, and NLR are correlated with the prognosis, respectively. The combination of CD8-positive TILs or TLSs and NLR may be the indicators to predict the prognosis of patients with pulmonary metastases from uterine leiomyosarcoma.

    DOI: 10.1245/s10434-023-14176-x

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  • Restrictive allograft dysfunction rather than bronchiolitis obliterans syndrome had a major impact on the overall survival after living-donor lobar lung transplantation.

    Kei Matsubara, Shinji Otani, Haruchika Yamamoto, Kohei Hashimoto, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Hiromasa Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Shinichi Toyooka

    Surgery today   2023.7

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    PURPOSE: Chronic lung allograft dysfunction (CLAD) is a known long-term fatal disorder after lung transplantation. In this study, we evaluated the CLAD classification of the International Society for Heart and Lung Transplantation (ISHLT) for living-donor lobar lung transplantation (LDLLT). METHODS: We conducted a single-center retrospective review of data from 73 patients who underwent bilateral LDLLT between 1998 and 2019. Factors related to opacity on computed tomography (CT) and restriction on pulmonary function tests (PFTs) were also analyzed. RESULTS: Overall, 26 (36%) patients were diagnosed with CLAD, including restrictive allograft syndrome (RAS), n = 10 (38.5%); bronchiolitis obliterans syndrome (BOS), n = 8 (30.8%); mixed, n = 1 (3.8%); undefined, n = 2 (7.7%); and unclassified, n = 5 (19.2%). The 5-year survival rate after the CLAD onset was 60.7%. The survival of patients with BOS was significantly better than that of patients with RAS (p = 0.012). In particular, patients with restriction on PFT had a significantly worse survival than those without restriction (p = 0.001). CONCLUSIONS: CLAD after bilateral LDLLT does not have a major impact on the recipient survival, especially in patients with BOS. Restriction on PFT may predict a particularly poor prognosis in patients with CLAD after bilateral LDLLT.

    DOI: 10.1007/s00595-023-02729-2

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  • Percentage of low attenuation area on computed tomography detects chronic lung allograft dysfunction, especially bronchiolitis obliterans syndrome, after bilateral lung transplantation. International journal

    Yujiro Kubo, Seiichiro Sugimoto, Toshio Shiotani, Kei Matsubara, Kohei Hashimoto, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Hiromasa Yamamoto, Mikio Okazaki, Shinichi Toyooka

    Clinical transplantation   e15077   2023.7

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    INTRODUCTION: The percentage of low attenuation area (%LAA) on computed tomography (CT) is useful for evaluating lung emphysema, and higher %LAA was observed in patients with chronic lung allograft dysfunction (CLAD). This study investigated the relationship between the %LAA and the development of CLAD after bilateral lung transplantation (LT). METHODS: We conducted a single-center retrospective study of 75 recipients who underwent bilateral LT; the recipients were divided into a CLAD group (n = 30) and a non-CLAD group (n = 45). The %LAA was calculated using CT and compared between the two groups from 4 years before to 4 years after the diagnosis of CLAD. The relationships between the %LAA and the percent baseline values of the pulmonary function test parameters were also calculated. RESULTS: The %LAA was significantly higher in the CLAD group than in the non-CLAD group from 2 years before to 2 years after the diagnosis of CLAD (P < .05). In particular, patients with bronchiolitis obliterans syndrome (BOS) exhibited significant differences even from 4 years before to 4 years after diagnosis (P < .05). Significant negative correlations between the %LAA and the percent baseline values of the forced expiratory volume in 1 s (r = -.36, P = .0031), the forced vital capacity (r = -.27, P = .027), and the total lung capacity (r = -.40, P < .001) were seen at the time of CLAD diagnosis. CONCLUSION: The %LAA on CT was associated with the development of CLAD and appears to have the potential to predict CLAD, especially BOS, after bilateral LT.

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  • Elderly lung transplant recipients show acceptable long-term outcomes for lung transplantation: A propensity score-matched analysis.

    Yasuaki Tomioka, Shin Tanaka, Shinji Otani, Toshio Shiotani, Haruchika Yamamoto, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    Surgery today   2023.6

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    PURPOSE: Although the performance lung transplantation (LTx) in the elderly (≥ 60 years) has increased globally, the situation in Japan remains quite different, because the age limit at registration for cadaveric transplantation is 60 years. We investigated the long-term outcomes of LTx in the elderly in Japan. METHODS: This was a single-center retrospective study. We divided the patients into two groups according to age: the younger group (< 60 years; Y group; n = 194) and the elderly group (≥ 60 years; E group; n = 10). We performed three-to-one propensity score matching to compare the long-term survival between the E and Y groups. RESULTS: In the E group, the survival rate was significantly worse (p = 0.003), and single-LTx was more frequent (p = 0.036). There was a significant difference in the indications for LTx between the two groups (p < 0.001). The 5-year survival rate after single-LTx in the E group was significantly lower than that in the Y group (p = 0.006). After propensity score matching, the 5-year survival rates of the two groups were comparable (p = 0.55). However, the 5-year survival rate after single-LTx in the E group was significantly lower than that in the Y group (p = 0.007). CONCLUSION: Elderly patients showed acceptable long-term survival after LTx.

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  • Identification of genetic loci associated with renal dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array. International journal

    Yasuaki Tomioka, Seiichiro Sugimoto, Haruchika Yamamoto, Shuta Tomida, Toshio Shiotani, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Hiromasa Yamamoto, Mikio Okazaki, Masaomi Yamane, Shinichi Toyooka

    Scientific reports   13 ( 1 )   8912 - 8912   2023.6

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    Renal dysfunction is a long-term complication associated with an increased mortality after lung transplantation (LT). We investigated the association of single-nucleotide polymorphisms (SNPs) with the development of renal dysfunction after LT using a Japanese-specific SNP array. First, eligible samples of 34 LT recipients were genotyped using the SNP array and divided into two groups, according to the presence of homozygous and heterozygous combinations of mutant alleles of the 162 renal-related SNPs. To identify candidate SNPs, the renal function tests were compared between the two groups for each SNP. Next, we investigated the association between the candidate SNPs and the time course of changes of the estimated glomerular filtration rate (eGFR) in the 99 recipients until 10 years after the LT. ΔeGFR was defined as the difference between the postoperative and preoperative eGFR values. Eight SNPs were identified as the candidate SNPs in the 34 recipients. Validation analysis of these 8 candidate SNPs in all the 99 recipients showed that three SNPs, namely, rs10277115, rs4690095, and rs792064, were associated with significant changes of the ΔeGFR. Pre-transplant identification of high-risk patients for the development of renal dysfunction after LT based on the presence of these SNPs might contribute to providing personalized medicine.

    DOI: 10.1038/s41598-023-36143-y

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  • Pulmonary alveolar proteinosis after lung transplantation: Two case reports and literature review. International journal

    Shinichi Kawana, Kentaroh Miyoshi, Shin Tanaka, Seiichiro Sugimoto, Dai Shimizu, Kei Matsubara, Mikio Okazaki, Noboru Hattori, Shinichi Toyooka

    Respirology case reports   11 ( 6 )   e01160   2023.6

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    Pulmonary alveolar proteinosis (PAP) affecting transplanted lungs is not well recognized. Herein, we report two cases of PAP after lung transplantation (LTx). The first case was a 4-year-old boy with hereditary pulmonary fibrosis who underwent bilateral LTx and presented with respiratory distress on postoperative day (POD) 23. He was initially treated for acute rejection, died due to infection on POD 248, and was diagnosed with PAP at autopsy. The second case involved a 52-year-old man with idiopathic pulmonary fibrosis who underwent bilateral LTx. On POD 99, chest computed tomography revealed ground-glass opacities. Bronchoalveolar lavage and transbronchial biopsy led to a diagnosis of PAP. Follow-up with immunosuppression tapering resulted in clinical and radiological improvement. PAP after lung transplantation mimics common acute rejection; however, is potentially transient or resolved with tapering immunosuppression, as observed in the second case. Transplant physicians should be aware of this rare complication to avoid misconducting immunosuppressive management.

    DOI: 10.1002/rcr2.1160

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  • Endobronchial Metastasis with Bloody Sputum 20 Years after Complete Resection of type A Non-Invasive Thymoma.

    Mototsugu Watanabe, Hiromasa Yamamoto, Kentaroh Miyoshi, Seiichiro Sugimoto, Shinichi Toyooka

    Acta medica Okayama   77 ( 3 )   331 - 334   2023.6

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    Masaoka stage I type A thymomas rarely recur. We report the case of an 82-year-old man who developed endobronchial metastasis after thymothymectomy for Masaoka stage I type A thymoma. Twenty years after surgery, the patient developed bloody sputum, and chest computed tomography revealed a neoplasm obstructing the right upper lobe bronchus of the lung with enlarged mediastinal lymph nodes. He underwent right upper lobectomy and mediastinal lymph node dissection. Although preoperative pathological diagnosis was squamous cell carcinoma of the lung, postoperative histopathology revealed endobronchial metastasis of the thymoma. Nine years later, at age 89, the patient is alive and well.

    DOI: 10.18926/AMO/65503

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  • One-year change in the health status predicts the subsequent hospitalization and mortality in patients waitlisted for lung transplantation in Japan. International journal

    Masaki Ikeda, Yusuke Wakatsuki, Toru Oga, Junko Tokuno, Seiichiro Sugimoto, Megumi Ishihara, Yoshinori Okada, Miki Akiba, Hidenao Kayawake, Satona Tanaka, Yoshito Yamada, Yojiro Yutaka, Akihiro Ohsumi, Daisuke Nakajima, Masatsugu Hamaji, Jumpei Kimura, Toyofumi F Chen-Yoshikawa, Hiroshi Date

    Respiratory investigation   61 ( 4 )   478 - 484   2023.5

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    BACKGROUND: Poor health-related quality of life (HRQL) at the registration for lung transplantation is related to waitlist mortality. We investigated the relationship between 1-year change in HRQL and subsequent outcomes in patients waitlisted for lung transplantation. METHODS: In a 5-year longitudinal study, we analyzed the factors related to waitlist mortality in 197 lung transplant patients registered on the Japan Organ Transplant Network. HRQL was assessed using St. George's Respiratory Questionnaire (SGRQ), and factors related to changes in SGRQ scores were evaluated after 1 year. We assessed the relationship between the 1-year change in SGRQ score and subsequent mortality or hospitalization. RESULTS: Among 197 patients, 108 remained waitlisted during the first-year assessment. During the median follow-up period of 469 d, 28 patients died, and 54 underwent lung transplantation. Univariate Cox proportional hazards analysis revealed that the changes in all components and total score of the SGRQ after 1 year were associated with waitlist mortality (p < 0.05). Stepwise multivariate analysis revealed that the 1-year changes in SGRQ scores were significantly related to waitlist mortality. Forty-three patients with worsened HRQL after 1 year had higher likelihoods of hospitalization (p = 0.038) and mortality (p = 0.026) after 1 and 4 years of follow-up, respectively, than 61 patients without worsened HRQL. CONCLUSIONS: Patients with worsened health status during the first year after registration had higher likelihoods of hospitalization and mortality after 1 and 4 years of follow-up, respectively, than those without worsened HRQL. Strategies to improve health status while waiting are needed to reduce waitlist hospitalization or mortality.

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  • S100A8/A9 as a prognostic biomarker in lung transplantation. International journal

    Kentaro Nakata, Mikio Okazaki, Shinichi Kawana, Yujiro Kubo, Dai Shimizu, Shin Tanaka, Kohei Hashimoto, Ken Suzawa, Kazuhiko Shien, Kentaroh Miyoshi, Hiromasa Yamamoto, Seiichiro Sugimoto, Shinichi Toyooka

    Clinical transplantation   e15006   2023.4

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    OBJECTIVES: S100A8/A9 is a damage-associated molecule that augments systemic inflammation. However, its role in the acute phase after lung transplantation (LTx) remains elusive. This study aimed to determine S100A8/A9 levels after lung transplantation (LTx) and evaluate their impact on overall survival (OS) and chronic lung allograft dysfunction (CLAD)-free survival. METHODS: Sixty patients were enrolled in this study, and their plasma S100A8/A9 levels were measured on days 0, 1, 2, and 3 after LTx. The association of S100A8/A9 levels with OS and CLAD-free survival was assessed using univariate and multivariate Cox regression analyses. RESULTS: S100A8/A9 levels were elevated in a time-dependent manner until 3 days after LTx. Ischemic time was significantly longer in the high S100A8/9 group than in the low S100A8/A9 group (p = .017). Patients with high S100A8/A9 levels (> 2844 ng/mL) had worse prognosis (p = .031) and shorter CLAD-free survival (p = .045) in the Kaplan-Meier survival analysis than those with low levels. Furthermore, multivariate Cox regression analysis showed that high S100A8/A9 levels were a determinant of poor OS (hazard ratio [HR]: 3.7; 95% confidence interval [CI]: 1.2-12; p = .028) and poor CLAD-free survival (HR: 4.1; 95% CI: 1.1-15; p = .03). In patients with a low primary graft dysfunction grade (0-2), a high level of S100A8/A9 was also a poor prognostic factor. CONCLUSIONS: Our study provided novel insights into the role of S100A8/A9 as a prognostic biomarker and a potential therapeutic target for LTx.

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  • 特集 外科手術と感染症 II. 各論 4. 呼吸器外科 1)肺合併症を減らすための周術期対策

    杉本 誠一郎, 豊岡 伸一

    外科   85 ( 5 )   557 - 564   2023.4

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (other academic)   Publisher:南江堂  

    DOI: 10.15106/j_geka85_557

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  • Diagnostic value of circulating microRNA-21 in chronic lung allograft dysfunction after bilateral cadaveric and living-donor lobar lung transplantation. International journal

    Toshio Shiotani, Seiichiro Sugimoto, Yasuaki Tomioka, Haruchika Yamamoto, Shin Tanaka, Kentaroh Miyoshi, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Mikio Okazaki, Shinichi Toyooka

    Heliyon   9 ( 4 )   e14903   2023.4

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    BACKGROUND: MicroRNAs (miRNAs) involved in the pathogenesis of pulmonary fibrosis have been shown to be associated with the development of chronic lung allograft dysfunction (CLAD) after lung transplantation (LT). We investigated the role of circulating miRNAs in the diagnosis of CLAD after bilateral LT, including cadaveric LT (CLT) and living-donor lobar LT (LDLLT). METHODS: The subjects of this retrospective study were 37 recipients of bilateral CLT (n = 23) and LDLLT (n = 14), and they were divided into a non-CLAD group (n = 24) and a CLAD group (n = 13). The plasma miRNA levels of the two groups were compared, and correlations between their miRNAs levels and percent baseline forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and total lung capacity (TLC) values were calculated from one year before to one year after the diagnosis of CLAD. RESULTS: The plasma levels of both miR-21 and miR-155 at the time of the diagnosis of CLAD were significantly higher in the CLAD group than in the non-CLAD group (miR-21, P = 0.0013; miR-155, P = 0.042). The miR-21 levels were significantly correlated with the percent baseline FEV1, FVC, and TLC value of one year before and at the time of diagnosis of CLAD (P < 0.05). A receiver operating characteristic curve analysis of the performance of miR-21 levels in the diagnosis of CLAD yielded an area under the curve of 0.89. CONCLUSION: Circulating miR-21 appears to be of potential value in diagnosing CLAD after bilateral LT.

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  • Donor's long-term quality of life following living-donor lobar lung transplantation. International journal

    Kento Fujii, Shin Tanaka, Megumi Ishihara, Kei Matsubara, Kohei Hashimoto, Shuji Okahara, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Hiromasa Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    Clinical transplantation   37 ( 4 )   e14927   2023.2

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    INTRODUCTION: Living-donor lobar lung transplantation is an alternative procedure to deceased donation lung transplantation. It involves graft donation from healthy donors; however, only a few reports have discussed its long-term prognosis in living lung donors and their associated health-related quality of life. This study aimed to examine living lung donors' health-related quality of life. METHODS: In our cross-sectional survey of living lung donors, we assessed health-related quality of life based on three key aspects (physical, mental, and social health) using the 36-Item Short Form Health Survey. We also evaluated chronic postoperative pain and postoperative breathlessness using the numeric rating scale and the modified Medical Research Council Dyspnea scale, respectively. RESULTS: We obtained consent from 117 of 174 living lung donors. The average scores of the living lung donors on the 36-Item Short Form Health Survey were higher than the national average. However, some donors had poorer physical, mental, and social health, with lower summary scores than the national averages. Low mental component summary predictors included donor age (<40 years; odds ratio = 10.2; p<.001) and recipient age (<18 years; odds ratio = 2.73; p<.032). Low role-social component summary predictors included high lung allocation score (≥50; odds ratio = 3.94, p<.002) and recipient death (odds ratio = 3.64; p = .005). There were no predictors for physical component summary. Additionally, many donors did not complain of pain or dyspnea. CONCLUSIONS: Living lung donors maintained acceptable long-term health-related quality of life after surgery. Potential donors should be informed of relevant risk factors, and high-risk donors should receive appropriate support. This article is protected by copyright. All rights reserved.

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  • Use of the index of pulmonary vascular disease for predicting long-term outcome of pulmonary arterial hypertension associated with congenital heart disease. International journal

    Ayako Chida-Nagai, Naoki Masaki, Kay Maeda, Konosuke Sasaki, Hiroki Sato, Jun Muneuchi, Yoshie Ochiai, Hiroomi Murayama, Masahiro Tahara, Atsuko Shiono, Atsushi Shinozuka, Fumihiko Kono, Daisuke Machida, Shinichi Toyooka, Seiichiro Sugimoto, Kazufumi Nakamura, Satoshi Akagi, Maiko Kondo, Shingo Kasahara, Yasuhiro Kotani, Junichi Koizumi, Katsuhiko Oda, Masako Harada, Daisuke Nakajima, Akira Murata, Hazumu Nagata, Koichi Yatsunami, Tomio Kobayashi, Yoshikiyo Matsunaga, Takahiro Inoue, Hiroyuki Yamagishi, Naomi Nakagawa, Katsuki Ohtani, Masaki Yamamoto, Yushi Ito, Tatsunori Hokosaki, Yuta Kuwahara, Satoshi Masutani, Koji Nomura, Tsutomu Wada, Hirofumi Sawada, Masayuki Abiko, Tatsunori Takahashi, Yuichi Ishikawa, Seigo Okada, Atsushi Naitoh, Takako Toda, Tatsuya Ando, Akihiro Masuzawa, Shinsuke Hoshino, Masaaki Kawada, Yuichi Nomura, Kentaro Ueno, Naoki Ohashi, Tsuyoshi Tachibana, Yuchen Cao, Hideaki Ueda, Sadamitsu Yanagi, Masaaki Koide, Norie Mitsushita, Kouji Higashi, Yoshihiro Minosaki, Tomohiro Hayashi, Takashi Okamoto, Kenji Kuraishi, Eiji Ehara, Hidekazu Ishida, Hitoshi Horigome, Takashi Murakami, Kohta Takei, Taku Ishii, Gen Harada, Yasutaka Hirata, Jun Maeda, Shunsuke Tatebe, Chiharu Ota, Yasunobu Hayabuchi, Hisanori Sakazaki, Takashi Sasaki, Keiichi Hirono, Sayo Suzuki, Masahiro Yasuda, Atsuhito Takeda, Madoka Sawai, Kagami Miyaji, Atsushi Kitagawa, Yosuke Nakai, Nobuyuki Kakimoto, Kouta Agematsu, Atsushi Manabe, Yoshikatsu Saiki

    Frontiers in cardiovascular medicine   10   1212882 - 1212882   2023

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    AIMS: Limited data exist on risk factors for the long-term outcome of pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD-PAH). We focused on the index of pulmonary vascular disease (IPVD), an assessment system for pulmonary artery pathology specimens. The IPVD classifies pulmonary vascular lesions into four categories based on severity: (1) no intimal thickening, (2) cellular thickening of the intima, (3) fibrous thickening of the intima, and (4) destruction of the tunica media, with the overall grade expressed as an additive mean of these scores. This study aimed to investigate the relationship between IPVD and the long-term outcome of CHD-PAH. METHODS: This retrospective study examined lung pathology images of 764 patients with CHD-PAH aged <20 years whose lung specimens were submitted to the Japanese Research Institute of Pulmonary Vasculature for pulmonary pathological review between 2001 and 2020. Clinical information was collected retrospectively by each attending physician. The primary endpoint was cardiovascular death. RESULTS: The 5-year, 10-year, 15-year, and 20-year cardiovascular death-free survival rates for all patients were 92.0%, 90.4%, 87.3%, and 86.1%, respectively. The group with an IPVD of ≥2.0 had significantly poorer survival than the group with an IPVD <2.0 (P = .037). The Cox proportional hazards model adjusted for the presence of congenital anomaly syndromes associated with pulmonary hypertension, and age at lung biopsy showed similar results (hazard ratio 4.46; 95% confidence interval: 1.45-13.73; P = .009). CONCLUSIONS: The IPVD scoring system is useful for predicting the long-term outcome of CHD-PAH. For patients with an IPVD of ≥2.0, treatment strategies, including choosing palliative procedures such as pulmonary artery banding to restrict pulmonary blood flow and postponement of intracardiac repair, should be more carefully considered.

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  • The impact of prognostic nutrition index on the waitlist mortality of lung transplantation.

    Kei Matsubara, Shinji Otani, Haruchika Yamamoto, Yasuaki Tomioka, Toshio Shiotani, Kentaroh Miyoshi, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    General thoracic and cardiovascular surgery   2022.12

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    OBJECTIVE: The prognostic nutrition index (PNI), calculated using serum albumin and total lymphocyte count, is a recent topical index related to inflammation. Preoperative PNI is regarded as a new preoperative prognostic score in lung transplantation (LTx). This study aimed to investigate the impact of PNI at the time of registration as a prognostic parameter of mortality on the waiting list for LTx. METHODS: A retrospective review was conducted on the data of 132 adult patients registered for LTx in our department between January 2013 and June 2020. Patients who finally received LTx were analyzed as censored data. The overall survival was evaluated using the Kaplan-Meier method for pre-registered clinical factors including the PNI at the time of registration. Overall survival was calculated from the date of listing to the Japan Organ Transplant Network to the date of death. RESULTS: The low-PNI group had a significantly worse prognosis. Multivariate analysis demonstrated that age (p = 0.023), idiopathic interstitial pneumonia (p < 0.001), lung allocation score (LAS) (p < 0.001), and PNI (p < 0.001) were independent prognostic factors for waitlist mortality. CONCLUSIONS: PNI at the time of registration can be an independent prognostic parameter in registered candidates for LTx.

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  • Functional Blockage of S100A8/A9 Ameliorates Ischemia-Reperfusion Injury in the Lung. International journal

    Kentaro Nakata, Mikio Okazaki, Tomohisa Sakaue, Rie Kinoshita, Yuhei Komoda, Dai Shimizu, Haruchika Yamamoto, Shin Tanaka, Ken Suzawa, Kazuhiko Shien, Kentaroh Miyoshi, Hiromasa Yamamoto, Toshiaki Ohara, Seiichiro Sugimoto, Masaomi Yamane, Akihiro Matsukawa, Masakiyo Sakaguchi, Shinichi Toyooka

    Bioengineering (Basel, Switzerland)   9 ( 11 )   2022.11

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    (1) Background: Lung ischemia-reperfusion (IR) injury increases the mortality and morbidity of patients undergoing lung transplantation. The objective of this study was to identify the key initiator of lung IR injury and to evaluate pharmacological therapeutic approaches using a functional inhibitor against the identified molecule. (2) Methods: Using a mouse hilar clamp model, the combination of RNA sequencing and histological investigations revealed that neutrophil-derived S100A8/A9 plays a central role in inflammatory reactions during lung IR injury. Mice were assigned to sham and IR groups with or without the injection of anti-S100A8/A9 neutralizing monoclonal antibody (mAb). (3) Results: Anti-S100A8/A9 mAb treatment significantly attenuated plasma S100A8/A9 levels compared with control IgG. As evaluated by oxygenation capacity and neutrophil infiltration, the antibody treatment dramatically ameliorated the IR injury. The gene expression levels of cytokines and chemokines induced by IR injury were significantly reduced by the neutralizing antibody. Furthermore, the antibody treatment significantly reduced TUNEL-positive cells, indicating the presence of apoptotic cells. (4) Conclusions: We identified S100A8/A9 as a novel therapeutic target against lung IR injury.

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  • 本邦における肺移植時の一酸化窒素(NO)ガス使用状況に関する実態調査

    吉安 展将, 佐藤 雅昭, 中島 大輔, 富岡 泰章, 渡辺 有為, 白石 武史, 舟木 壮一郎, 前田 寿美子, 朝重 耕一, 中島 崇裕, 土谷 智史, 杉本 誠一郎, 吉野 一郎, 永安 武, 千田 雅之, 南 正人, 岡田 克典, 豊岡 伸一, 伊達 洋至, 中島 淳

    日本呼吸器外科学会雑誌   36 ( 7 )   722 - 734   2022.11

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  • Inhibiting S100A8/A9 attenuates airway obstruction in a mouse model of heterotopic tracheal transplantation. International journal

    Dai Shimizu, Mikio Okazaki, Seiichiro Sugimoto, Rie Kinoshita, Kentaro Nakata, Shin Tanaka, Kohei Hashimoto, Kentaroh Miyoshi, Masaomi Yamane, Akihiro Matsukawa, Masakiyo Sakaguchi, Shinichi Toyooka

    Biochemical and biophysical research communications   629   86 - 94   2022.8

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    Although bronchiolitis obliterans syndrome (BOS) is a major cause of death after lung transplantation, an effective drug therapy for BOS has not yet developed. Here, we assessed the effectiveness of a neutralizing anti-S100 calcium binding protein (S100) A8/A9 antibody against BOS. A murine model of heterotopic tracheal transplantation was used. Mice were intraperitoneally administered control IgG or the S100A8/A9 antibody on day 0 and twice per week until they were sacrificed. Tissue sections were used to evaluate the obstruction ratio, epithelium-preservation ratio, α-smooth muscle actin (SMA)-positive myofibroblast infiltration, and luminal cell death. Quantitative reverse transcriptase-polymerase chain reaction analysis was performed to analyze the mRNA-expression levels of collagen, inflammatory cytokines, and chemokines on days 7, 14, and 21. The anti-S100A8/A9 antibody significantly improved the obstruction ratio and epithelium-preservation ratio, with less α-SMA-positive myofibroblast infiltration compared to the control group. Antibody treatment reduced the type-III collagen: type-I collagen gene-expression ratio. The antibody also significantly suppressed the number of dead cells in the graft lumen. The expression levels of tumor growth factor β1 and C-C motif chemokine 2 on day 21, but not those of interleukin-1β, interleukin-6, and tumor necrosis factor α, were significantly suppressed by S100A8/A9 antibody treatment. These findings suggest that S100A8/A9 may be a potential therapeutic target for BOS after lung transplantation.

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  • Lung recruitment after cardiac arrest during procurement of atelectatic donor lungs is a protective measure in lung transplantation. International journal

    Eito Niman, Kentaroh Miyoshi, Toshio Shiotani, Tomohiro Toji, Takuro Igawa, Shinji Otani, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    Journal of thoracic disease   14 ( 8 )   2802 - 2811   2022.8

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    Background: Brain-dead donors are susceptible to pulmonary atelectasis (AT). In procurement surgery, lung recruitment under circulatory conditions and cold-flushing for atelectatic donor lungs often provoke graft injury due to the acute blood inflow. We hypothesized that lung recruitment without blood circulation can mitigate graft injury. This study aimed to examine the benefits of lung recruitment subsequent to cardiac arrest using a porcine lung-transplant model. Methods: Thirteen donor pigs were categorized into the non-atelectatic (No-AT) group (n=3) representing a healthy control group; AT-BCR group (n=5), in which AT was reverted by conventional blood-circulated recruitment (BCR); and AT-no-BCR group (n=5), in which AT was reverted by no-BCR following circulatory arrest. In the atelectatic donor models, the left main bronchus was ligated for 24 hours prior to lung procurement. Left lung transplantation (LTx) was subsequently performed in the thirteen recipient pigs. After 6 hours evaluation, the recipients were euthanized and the lung grafts were excised. Results: The post-transplant PaO2/FiO2 ratio was significantly higher in the AT-no-BCR group than in the AT-BCR group (P=0.015). Wet/dry ratio, histological findings of graft injury and tissue interleukin-8 expression in the AT-no-BCR group were similar to those of the No-AT group. Conclusions: Lung recruitment without circulation after circulatory arrest could be more protective for atelectatic donor lung than the conventional procedure.

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  • Drug repositioning of tranilast to sensitize a cancer therapy by targeting cancer-associated fibroblast. International journal

    Kosuke Ochi, Ken Suzawa, Yin Min Thu, Fumiaki Takatsu, Shimpei Tsudaka, Yidan Zhu, Kentaro Nakata, Tatsuaki Takeda, Kazuhiko Shien, Hiromasa Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Tadahiko Shien, Yoshiharu Okamoto, Shuta Tomida, Shinichi Toyooka

    Cancer science   113 ( 10 )   3428 - 3436   2022.7

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    Cancer-associated fibroblasts (CAFs) are a major component of the tumor microenvironment that mediate resistance of cancer cells to anticancer drugs. Tranilast is an antiallergic drug that suppresses the release of cytokines from various inflammatory cells. In this study, we investigated the inhibitory effect of tranilast on the interactions between non-small cell lung cancer (NSCLC) cells and the CAFs in the tumor microenvironment. Three EGFR-mutant NSCLC cell lines, two KRAS-mutant cell lines and three CAFs derived from NSCLC patients were used. To mimic the tumor microenvironment, the NSCLC cells were co-cultured with the CAFs in vitro, and the molecular profiles and sensitivity to molecular targeted therapy were assessed. Crosstalk between NSCLC cells and CAFs induced multiple biological effects on the NSCLC cells both in vivo and in vitro, including activation of the STAT3 signaling pathway, promotion of xenograft tumor growth, induction of epithelial-mesenchymal transition (EMT), and acquisition of resistance to molecular-targeted therapy, including of EGFR-mutant NSCLC cells to osimertinib and of KRAS-mutant NSCLC cells to selumetinib. Treatment with tranilast led to inhibition of IL-6 secretion from the CAFs, which, in turn, resulted in inhibition of CAF-induced phospho-STAT3 upregulation. Tranilast also inhibited CAF-induced EMT in the NSCLC cells. Finally, combined administration of tranilast with molecular-targeted therapy reversed the CAF-mediated resistance of the NSCLC cells to the molecular-targeted drugs, both in vitro and in vivo. Our results showed that combined administration of tranilast with molecular-targeted therapy is a possible new treatment strategy to overcome drug resistance caused by cancer- CAF interaction.

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  • Robotic Mediastinal Tumor Resections: Position and Port Placement. International journal

    Mikio Okazaki, Kazuhiko Shien, Ken Suzawa, Seiichiro Sugimoto, Shinichi Toyooka

    Journal of personalized medicine   12 ( 8 )   2022.7

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    This study aimed to determine the optimal position and port placement during robotic resection for various mediastinal tumors. For anterior mediastinal tumors, total or extended thymectomy is commonly performed in the supine position using the lateral or subxiphoid approach. Although it is unclear which approach is better during robotic thymectomy, technical advantages of subxiphoid approach are beneficial for patients with myasthenia who require extended thymectomy. Partial thymectomy is performed in the supine position using a lateral approach. Superior, middle, and posterior mediastinal tumors are resected in the decubitus position using the lateral approach, whereas dumbbell tumor resection, which requires a posterior approach, can be performed in the prone position. The position and port placement should be chosen depending on the size, location, and aggressiveness of the tumor. In this study, we describe how to choose which of these different robotic approaches can be used based on our experience and previous reports.

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  • One-step nucleic acid amplification for intraoperative diagnosis of lymph node metastasis in lung cancer patients: a single-center prospective study. International journal

    Kei Namba, Ken Suzawa, Kazuhiko Shien, Akihiro Miura, Yuta Takahashi, Shunsaku Miyauchi, Kota Araki, Kentaro Nakata, Shuta Tomida, Shin Tanaka, Kentaroh Miyoshi, Shinji Otani, Hiromasa Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Junichi Soh, Masaomi Yamane, Shinichi Toyooka

    Scientific reports   12 ( 1 )   7297 - 7297   2022.5

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    One-step nucleic acid amplification (OSNA) is a rapid intraoperative molecular detection technique for sentinel node assessment via the quantitative measurement of target cytokeratin 19 (CK19) mRNA to determine the presence of metastasis. It has been validated in breast cancer but its application in lung cancer has not been adequately investigated. 214 LNs from 105 patients with 100 primary lung cancers, 2 occult primary lung tumors, and 3 metastatic lung tumors, who underwent surgical lung resection with LN dissection between February 2018 and January 2020, were assessed. Resected LNs were divided into two parts: one was snap-frozen for OSNA and the other underwent rapidly frozen histological examination. Intraoperatively collected LNs were evaluated by OSNA using loop-mediated isothermal amplification and compared with intraoperative pathological diagnosis as a control. Among 214 LNs, 14 were detected as positive by OSNA, and 11 were positive by both OSNA and intraoperative pathological diagnosis. The sensitivity and specificity of OSNA was 84.6% and 98.5%, respectively. The results of 5 of 214 LNs were discordant, and the remainder all matched (11 positive and 198 negative) with a concordance rate of 97.7%. Although the analysis of public mRNA expression data from cBioPortal showed that CK19 expression varies greatly depending on the cancer type and histological subtype, the results of the five cases, except for primary lung cancer, were consistent. OSNA provides sufficient diagnostic accuracy and speed and can be applied to the intraoperative diagnosis of LN metastasis for non-small cell lung cancer.

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  • Survival and prognostic factors in patients undergoing pulmonary metastasectomy for lung metastases from retroperitoneal sarcoma. International journal

    Fumiaki Takatsu, Hiromasa Yamamoto, Yasuaki Tomioka, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Katsuhito Takahashi, Shinichi Toyooka

    World journal of surgical oncology   20 ( 1 )   114 - 114   2022.4

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    BACKGROUND: Soft-tissue sarcomas are rare malignancies that consist of many different histologic subtypes and arise in various locations in the body. In patients with lung metastases from retroperitoneal sarcomas, the long-term outcomes and prognostic factors are unknown. This study is a retrospective review of patients undergoing pulmonary metastasectomy for retroperitoneal sarcoma metastases at one institution, with the purpose of determining prognostic factors and clinical outcomes. METHODS: This is a single-center, retrospective cohort study of patients undergoing pulmonary metastasectomy for lung metastases from various sarcomas at Okayama University Hospital from January 2006 to December 2018. The Kaplan-Meier method and log-rank test were used for the analyses, and cut-off values of continuous variables were determined by a receiver operating characteristic curve analysis. RESULTS: Twenty-four patients underwent the first pulmonary metastasectomy for lung metastases from retroperitoneal sarcoma in our hospital. Leiomyosarcoma was the most common histologic subtype of retroperitoneal sarcoma (79.2%, n = 19). Median overall survival was 49.9 months, and the 3-year and 5-year survival rates after the first pulmonary metastasectomy were 62.5% and 26.4% respectively. In univariate analysis, age ≥56 years, disease-free interval < 15 months, and size of metastasis (≥ 27 mm) were associated with poor survival. CONCLUSION: Pulmonary metastasectomy can be considered as an effective management strategy in retroperitoneal sarcoma patients with lung metastases in appropriately selected cases, just as it is for other sarcomas.

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  • 【肺移植の現況と課題そして展望】生体肺移植後の慢性移植肺機能不全(CLAD)

    杉本 誠一郎, 田中 真, 三好 健太郎, 豊岡 伸一

    胸部外科   75 ( 4 )   297 - 301   2022.4

  • Paediatric lung transplantation: the impact of age on the survival.

    Shinji Otani, Haruchika Yamamoto, Shin Tanaka, Yasuaki Tomioka, Kei Matsubara, Dai Shimizu, Toshio Shiotani, Ken Suzawa, Kentaroh Miyoshi, Hiromasa Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    Surgery today   52 ( 11 )   1540 - 1550   2022.3

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    OBJECTIVES: We herein review the outcomes of paediatric lung transplantation (LTx) and analyse subgroups divided by age. METHODS: We retrospectively reviewed 43 consecutive paediatric LTx recipients (< 18 years old: cadaveric LTx [n = 9], living-donor lobar LTx [n = 34]). We also analysed subgroups of patients 1-6 years old (n = 10) and 7-17 years old (n = 33). RESULTS: The 1-, 5- and 10-year overall survival (OS) rates in paediatric recipients were 93%, 82% and 67%, respectively. The 1-, 5- and 10-year graft dysfunction (GD)-free survival rates in paediatric recipients were 85%, 59% and 31%, respectively. The 1- and 5-year OS in the 1- to 6-year-old vs. 7- to 17-year-old groups were 70% vs. 100% and 48% vs. 93%, respectively (p < 0.0001). The 1- and 5-year GD-free survival rates in the 1- to 6-year-old vs. 7- to 17-year-old groups were 60% vs. 93% and 24% vs. 69%, respectively (p = 0.024). The 1- to 6-year-old group showed higher rates of non-standard LTx (p = 0.0001), interstitial pneumonia (p = 0.004) and ventilator dependency (p = 0.007) than the 7- to 17-year-old group. CONCLUSION: Paediatric recipients under 7 years old seemed to have a higher risk of mortality and GD than those 7 years old and older.

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  • Identification of targetable kinases in idiopathic pulmonary fibrosis. International journal

    Hisao Higo, Kadoaki Ohashi, Shuta Tomida, Sachi Okawa, Hiromasa Yamamoto, Seiichiro Sugimoto, Satoru Senoo, Go Makimoto, Kiichiro Ninomiya, Takamasa Nakasuka, Kazuya Nishii, Akihiko Taniguchi, Toshio Kubo, Eiki Ichihara, Katsuyuki Hotta, Nobuaki Miyahara, Yoshinobu Maeda, Shinichi Toyooka, Katsuyuki Kiura

    Respiratory research   23 ( 1 )   20 - 20   2022.2

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    BACKGROUND: Tyrosine kinase activation plays an important role in the progression of pulmonary fibrosis. In this study, we analyzed the expression of 612 kinase-coding and cancer-related genes using next-generation sequencing to identify potential therapeutic targets for idiopathic pulmonary fibrosis (IPF). METHODS: Thirteen samples from five patients with IPF (Cases 1-5) and eight samples from four patients without IPF (control) were included in this study. Six of the thirteen samples were obtained from different lung segments of a single patient who underwent bilateral pneumonectomy. Gene expression analysis of IPF lung tissue samples (n = 13) and control samples (n = 8) was performed using SureSelect RNA Human Kinome Kit. The expression of the selected genes was further confirmed at the protein level by immunohistochemistry (IHC). RESULTS: Gene expression analysis revealed a correlation between the gene expression signatures and the degree of fibrosis, as assessed by Ashcroft score. In addition, the expression analysis indicated a stronger heterogeneity among the IPF lung samples than among the control lung samples. In the integrated analysis of the 21 samples, DCLK1 and STK33 were found to be upregulated in IPF lung samples compared to control lung samples. However, the top most upregulated genes were distinct in individual cases. DCLK1, PDK4, and ERBB4 were upregulated in IPF case 1, whereas STK33, PIM2, and SYK were upregulated in IPF case 2. IHC revealed that these proteins were expressed in the epithelial layer of the fibrotic lesions. CONCLUSIONS: We performed a comprehensive kinase expression analysis to explore the potential therapeutic targets for IPF. We found that DCLK1 and STK33 may serve as potential candidate targets for molecular targeted therapy of IPF. In addition, PDK4, ERBB4, PIM2, and SYK might also serve as personalized therapeutic targets of IPF. Additional large-scale studies are warranted to develop personalized therapies for patients with IPF.

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  • Completely Video-assisted Thoracoscopic Lobectomy for Congenital Lobar Emphysema in a Young Adult.

    Tsuyoshi Ryuko, Hiromasa Yamamoto, Seiichiro Sugimoto, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Mikio Okazaki, Masaomi Yamane, Shinichi Toyooka

    Acta medica Okayama   76 ( 1 )   89 - 92   2022.2

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    Congenital lobar emphysema (CLE) is defined as the hyperinflation of pulmonary lobes due to obstruction of the flow of air via a known or unknown etiology, which causes pressure symptoms in the adjacent organs. CLE is mainly diagnosed in the neonatal period, and very few adult cases have been reported. Here we report a 34-year-old male with muscular dystrophy who was diagnosed with CLE on examination. He underwent a right lower lobectomy via 3-portal completely video-assisted thoracoscopic surgery, and his symptoms improved. Thoracoscopic surgery helped preserve the respiratory muscles and led to the improvement of respiratory function in this patient.

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  • Acute Pulmonary Edema Due to Arteriovenous Shunt Placement after Lung Transplant. International journal

    Dai Shimizu, Kentaroh Miyoshi, Seiichiro Sugimoto, Tomoko Toma, Yusuke Matsuda, Yasuaki Tomioka, Toshio Shiotani, Shinji Otani, Masaomi Yamane, Shinichi Toyooka

    The Annals of thoracic surgery   2022.1

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    Lung transplant recipients are often complicated by immunosuppressant-induced nephropathy, which may require renal replacement therapy. We report a case of unilateral lung edema and pulmonary hypertension due to arteriovenous fistula placement in a patient with unilateral chronic lung allograft dysfunction after bilateral living-donor lobar lung transplantation. Lung transplant recipients with limited residual vascular beds, such as lobar graft or severe deviation in lung perfusion, are vulnerable to the acute increase in blood flow due to arteriovenous fistula placement and can easily develop pulmonary edema regardless of the left ventricular function. Hence, careful volume control is required.

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  • Pulmonary Enteric Adenocarcinoma Harboring a BRAF G469V Mutation.

    Dai Shimizu, Hiromasa Yamamoto, Kazuhiko Shien, Kohei Taniguchi, Kentaroh Miyoshi, Kei Namba, Kumi Mesaki, Seiichiro Sugimoto, Junichi Soh, Masaomi Yamane, Shinichi Toyooka

    Acta medica Okayama   75 ( 6 )   759 - 762   2021.12

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    Pulmonary enteric adenocarcinoma (PEAC) is a rare subtype of lung cancer that should be differentiated from colorectal cancer metastasis. Little is known about its genetic background. An 84-year-old male with adenocarcinoma of the lung underwent left upper lobectomy. The histology of the surgical specimen was suggestive of PEAC. Gastrointestinal and colorectal fiberscopy revealed no evidence of colorectal cancer. Next-generation sequencing of the tumor identified a G469V substitution in serine/threonine-protein kinase B-raf (BRAF). Based on the higher prevalence of the G469 substitution in BRAF-mutant lung adenocarcinoma than in BRAFmutant colorectal cancer, the tumor likely originated from the lung. Identification of mutational genotype may be of some help in distinguishing PEAC from the lung metastasis of colorectal cancer.

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  • Long-term outcomes of living-donor lobar lung transplantation. Reviewed International journal

    Seiichiro Sugimoto, Hiroshi Date, Kentaroh Miyoshi, Shinji Otani, Megumi Ishihara, Masaomi Yamane, Shinichi Toyooka

    The Journal of thoracic and cardiovascular surgery   2021.11

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    OBJECTIVE: Although living-donor lobar lung transplantation (LDLLT) enables an intermediate survival similar to cadaveric lung transplantation, the long-term outcome remains unknown. We examined the long-term outcomes of 30 patients who received LDLLT more than 16 years previously. METHODS: We retrospectively reviewed the clinical data of 30 patients who underwent LDLLT (bilateral LDLLT, 29 patients; single LDLLT, 1 pediatric patient) between October 1998 and April 2004. RESULTS: LDLLT was performed for 25 female and 5 male patients ranging in age from 8 to 55 years. The diagnoses included pulmonary hypertension (n = 11), pulmonary fibrosis (n = 7), bronchiolitis obliterans (n = 5), and others (n = 7). At a median follow-up of 205 months, 22 patients were alive and 8 were dead. The causes of death were infection (n = 3), malignancy (n = 2), acute rejection (n = 2), and chronic lung allograft dysfunction (CLAD; n = 1). Unilateral CLAD occurred in 17 patients (56.7%), but only 1 of these patients subsequently developed bilateral CLAD. Two patients underwent bilateral cadaveric lung retransplantations. The 5-, 10-, and 15-year CLAD-free survival rates were 80.0%, 62.8%, and 44.3%, respectively. Malignancy occurred in 7 patients. Two of 5 patients with chronic kidney disease requiring hemodialysis underwent living-donor kidney transplantation. The 5-, 10-, and 15-year overall survival rates were 96.7%, 86.7%, and 73.3%, respectively. CONCLUSIONS: Although only 2 lobes are implanted, LDLLT provides encouraging long-term outcomes. In patients with unilateral CLAD, the functioning contralateral graft might contribute to a favorable long-term outcome.

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  • Effect of preoperative long-term use of corticosteroids on the development of post-transplant lymphoproliferative disorders after lung transplantation: a single-center experience in Japan. Reviewed

    Dai Shimizu, Shinji Otani, Seiichiro Sugimoto, Haruchika Yamamoto, Yasuaki Tomioka, Toshio Shiotani, Kentaroh Miyoshi, Mikio Okazaki, Masaomi Yamane, Shinichi Toyooka

    Surgery today   52 ( 4 )   697 - 704   2021.10

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    PURPOSE: Post-transplant lymphoproliferative disorder (PTLD) is a major complication of lung transplantation (LTx). However, few studies on PTLD in Asian populations have been reported. We explored the characteristics of Japanese PTLD cases after LTx. METHODS: We retrospectively reviewed 195 cases of LTx at our institute. We summarized the clinical experiences of 7 PTLD cases and analyzed the patient characteristics and survival outcomes of patients with (n = 7) and without (n = 188) PTLD. RESULTS: All PTLD patients were taking corticosteroids preoperatively (p = 0.0030), and the duration of preoperative corticosteroid therapy was significantly longer in the PTLD group (p = 0.0064) than in the non-PTLD group. The overall survival after LTx was significantly worse in the PTLD group (p = 0.027) than in the non-PLTD group. Among the three patients who died within 1 year after the PTLD onset, two died of opportunistic infections without residual PTLD lesions. Chronic lung allograft dysfunction (CLAD) or bronchiolitis obliterans at an autopsy were diagnosed after PTLD treatment in four cases. CONCLUSIONS: Long-term preoperative corticosteroid therapy may be a risk factor for PTLD after LTx. Opportunistic infections are lethal complications of PTLD, regardless of the effectiveness of PTLD treatment. CLAD occurs at a high rate after PTLD treatment, and close monitoring is required.

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  • Meticulous closure of collateral vessels in the perihilar mediastinal pleura to control intraoperative bleeding during lung transplantation for pulmonary hypertension. Reviewed International journal

    Haruchika Yamamoto, Seiichiro Sugimoto, Kentaro Imanishi, Kohei Hashimoto, Kentaroh Miyoshi, Shinji Otani, Masaomi Yamane, Shinichi Toyooka

    Journal of thoracic disease   13 ( 10 )   5658 - 5669   2021.10

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    Background: Massive blood transfusion compensating hemorrhage during lung transplantation (LT) results in primary graft dysfunction (PGD) and worse outcomes after LT. Collateral vessels in the perihilar mediastinal pleura could be the source of hemorrhage during LT in patients with pulmonary hypertension (PH). The purpose of this study was to examine the effect of closure with hemoclips of the vessels in the perihilar mediastinal pleura on the risk of intraoperative hemorrhage and outcomes after LT in patients with PH. Methods: We retrospectively reviewed 80 patients who underwent LT, including 13 patients with primary PH, 29 patients with secondary PH, and 38 patients with non-PH. Results: The median number of hemoclips was significantly higher in the primary PH group than in the non-PH group (P=0.0045) or secondary PH group (P=0.0060). The intraoperative blood loss, transfusion volume, maximum PGD grade, and the 30-day and 90-day mortality rates in the primary PH group were equivalent to those in the other two groups. Conclusions: Meticulous closure of collateral vessels in the perihilar mediastinal pleura during LT in patients with primary PH allowed intraoperative hemorrhage to be controlled and might be associated with acceptable mortality rate in these patients similar to that of LT in patients with other diseases.

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  • Lung transplantation for idiopathic multicentric Castleman disease: potential efficacy and tolerability of a humanized anti-interleukin-6 receptor monoclonal antibody. Reviewed International journal

    Yasuaki Tomioka, Shinji Otani, Shin Tanaka, Kazuhiko Shien, Ken Suzawa, Kentaroh Miyoshi, Hiromasa Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    Surgical case reports   7 ( 1 )   209 - 209   2021.9

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    BACKGROUND: Idiopathic multicentric Castleman disease (iMCD) is a rare polyclonal lymphoproliferative disease caused by the overrepresentation of interleukin-6 (IL-6). Tocilizumab (TCZ) is a humanized monoclonal antibody that binds to the IL-6 receptor and is approved for the treatment of iMCD. The efficacy and tolerability of TCZ in patients with iMCD undergoing lung transplantation (LTx) remain unknown. CASE PRESENTATION: We present the case of a 48-year-old iMCD patient with end-stage lung disease (ESLD) who was successfully treated with cadaveric single-LTx. Intravenous TCZ was used to stabilize the iMCD patient every 2 weeks, except for withdrawal immediately after LTx. At 32 month post-transplant, the patient remained asymptomatic without evidence of rejection, development of de novo donor-specific antibody (DSA), and recurrent iMCD in the native lung. CONCLUSIONS: Single-LTx can be a feasible treatment option for ESLD caused by iMCD. TCZ can be used safely and may be beneficial in recipients with iMCD, and TCZ in combination with usual immunosuppression can be helpful in stabilizing iMCD patients pre- and post-LTx.

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  • Characterization of localized macrophages in bronchiolitis obliterans after allogeneic hematopoietic cell transplantation. Reviewed

    Taiga Kuroi, Nobuharu Fujii, Koichi Ichimura, Keisuke Seike, Akira Yamamoto, Yui Kambara, Seiichiro Sugimoto, Shinji Otani, Kyosuke Saeki, Hideaki Fujiwara, Hisakazu Nishiomori, Takahiro Oto, Yoshinobu Maeda

    International journal of hematology   114 ( 6 )   701 - 708   2021.9

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    BACKGROUND: Bronchiolitis obliterans syndrome (BOS) remains one of the most devastating manifestations of chronic graft-versus-host disease in hematopoietic cell transplantation (HCT). Recent findings of BOS after lung transplantation indicate that donor (lung)-derived lung-resident macrophages contribute to BOS, suggesting that differences in the origin of immune cells and localized antigen-presenting cells cause the onset of BOS. METHODS: We identified the phenotype and origin of infiltrating macrophages using immunohistochemistry and fluorescence in situ hybridization in eight sex-mismatched HCT recipients who underwent lung transplantation for BOS after HCT. RESULTS: Most of the infiltrating macrophages appeared to be derived from donor (hematopoietic) cells in patients who developed BOS following HCT. Macrophages observed in the early-stage region of BOS were positive for cluster of differentiation (CD)68 and inducible nitric oxide synthase (iNOS) and negative for CD163 and CD206, suggesting an M1 phenotype. In the late-stage region, macrophages were negative for CD68 and iNOS in all patients, but also positive for CD163 and CD206 in some patients. CONCLUSIONS: Donor-derived M1-macrophages may be involved in the pathogenesis of the early-stage region of BOS. In addition, some macrophages in the late-stage region showed M2 polarization that might be involved in fibrosis.

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  • Protective effects of anti-HMGB1 monoclonal antibody on lung ischemia reperfusion injury in mice. Reviewed International journal

    Kentaro Nakata, Mikio Okazaki, Dai Shimizu, Ken Suzawa, Kazuhiko Shien, Kentaroh Miyoshi, Shinji Otani, Hiromasa Yamamoto, Seiichiro Sugimoto, Masaomi Yamane, Daiki Ousaka, Toshiaki Ohara, Akihiro Matsukawa, Masahiro Nishibori, Shinichi Toyooka

    Biochemical and biophysical research communications   573   164 - 170   2021.8

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    During ischemia reperfusion (IR) injury, high mobility group box 1 (HMGB1), a chromatin binding protein, is released from necrotic cells and triggers inflammatory responses. We assessed the therapeutic effect of a neutralizing anti-HMGB1 monoclonal antibody (mAb) on lung IR injury. A murine hilar clamp model of IR was used, where mice were divided into sham and IR groups with intravenous administration of anti-HMGB 1 mAb or control mAb. We analyzed the effect of anti-HMGB1 mAb against IR injury by assessing lung oxygenation, lung injury score, neutrophil infiltration, expression of proinflammatory cytokines and chemokines, levels of mitogen-activated protein kinase (MAPK) signaling, and measurement of apoptotic cells. Anti-HMGB1 mAb significantly decreased the plasma level of HMGB1 elevated by IR. The severity of IR injury represented by oxygenation capacity, lung injury score, and neutrophil infiltration was significantly improved by anti-HMGB1 mAb treatment. The expression of proinflammatory factors, including IL-1β, IL-6, IL-12, TNF-α, CXCL-1, and CXCL-2, and phosphorylation of p38 MAPK were both significantly reduced by anti-HMGB1 mAb treatment. Furthermore, anti-HMGB1 mAb treatment suppressed apoptosis, as determined through TUNEL assays. Overall, anti-HMGB1 mAb ameliorated lung IR injury by reducing inflammatory responses and apoptosis. Our findings indicate that anti-HMGB1 mAb has potential for use as a therapeutic to improve IR injury symptoms during lung transplantation.

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  • Robot-assisted thoracoscopic lobectomy for severe incomplete interlober fissure. Reviewed International journal

    Mikio Okazaki, Ken Suzawa, Kazuhiko Shien, Kentaroh Miyoshi, Shinji Otani, Hiromasa Yamamoto, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    Journal of surgical case reports   2021 ( 8 )   rjab336   2021.8

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    An incomplete interlobar fissure makes thoracoscopic lobectomy difficult and is predictive of morbidity after thoracoscopic lobectomy. This report demonstrates the robot-assisted thoracoscopic (RATS) lobectomy technique for patients with severe incomplete interlobar fissures. A fissureless approach was chosen for pulmonary resection. Near-infrared fluorescence imaging with intravenous indocyanine green (ICG) was used to detect the interlobar line after transection of the bronchus, pulmonary artery and vein. Interlobar fissure was identified and divided by robotic staplers. This combined technique using ICG and fissureless lobectomy made RATS lobectomy safe for patients with severe incomplete interlobar fissures.

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  • Emphysematous changes and lower levels of plasma irisin are associated with bronchiolitis obliterans syndrome after bilateral living-donor lobar lung transplantation. Reviewed

    Toshio Shiotani, Seiichiro Sugimoto, Haruchika Yamamoto, Kentaroh Miyoshi, Shinji Otani, Ken Suzawa, Hiromasa Yamamoto, Mikio Okazaki, Masaomi Yamane, Shinichi Toyooka

    Surgery today   52 ( 2 )   294 - 305   2021.7

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    PURPOSE: Decreased irisin levels may be associated with the development of emphysema. Similarly, emphysematous changes may develop in patients with chronic lung allograft dysfunction (CLAD) after living-donor lobar lung transplantation (LDLLT). We investigated the severity of emphysematous changes and the relationship between irisin levels and CLAD after bilateral LDLLT and cadaveric lung transplantation (CLT). METHODS: The subjects of this retrospective study were 59 recipients of bilateral LDLLT (n = 31) or CLT (n = 28), divided into a non-CLAD group (n = 41), a LDLLT-CLAD group (n = 11), and a CLT-CLAD group (n = 7). We compared the severity of emphysematous changes, the skeletal muscle mass, and the plasma irisin levels among the groups. RESULTS: The emphysematous changes were significantly more severe in the LDLLT-CLAD and CLT-CLAD groups (p = 0.046 and 0.036), especially in patients with bronchiolitis obliterans syndrome (BOS), than in the non-CLAD group. Although the skeletal muscle mass was similar in all the groups, the plasma irisin levels were significantly lower in the LDLLT-CLAD group (p = 0.022), especially in the patients with BOS after LDLLT, than in the non-CLAD group. CONCLUSION: Emphysematous changes and lower levels of plasma irisin were associated with CLAD, especially in patients with BOS, after bilateral LDLLT.

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  • Lung transplantation for bronchiectasis due to hyper-immunoglobulin E syndrome. Reviewed International journal

    Dai Shimizu, Shinji Otani, Seiichiro Sugimoto, Haruchika Yamamoto, Yasuaki Tomioka, Toshio Shiotani, Kentaroh Miyoshi, Mikio Okazaki, Masaomi Yamane, Shinichi Toyooka

    The Annals of thoracic surgery   113 ( 4 )   e251-e253   2021.7

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    Hyper-immunoglobulin E syndrome (HIES) is one of the primary immunodeficiencies characterized by recurrent staphylococcal skin and lung infections that result in lung destruction and critically diminished pulmonary function. Despite the lack of definitive treatment, there have been no reports of successful lung transplantation (LTx) for HIES patients. We report the case of a 42-year-old female HIES patient with progressive bronchiectasis whose pulmonary infection was controlled prior to transplantation and subsequent LTx was uneventful. LTx may be feasible in HIES if the patient is immunologically stable preoperatively, and peri-operative infections, especially Aspergillus infections, are well-controlled.

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  • 肺移植後の抗体関連拒絶に対するrituximab(遺伝子組換え) Reviewed

    芳川 豊史, 伊達 洋至, 杉本 誠一郎, 白石 武史, 中川 健, 江川 裕人

    移植   56 ( 1 )   53 - 68   2021.7

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    日本国内で実施された肺移植525例を対象に、肺移植後に抗体関連型拒絶反応(AMR)を発症し、rituximabを使用した症例について検討した。その結果、肺移植後のAMRに対しrituximabを使用した症例は14例(2.7%)であった。移植時年齢は10歳が1例、23〜69歳が13例であった。rituximabは延べ20回投与され、うち11例は375mg/m2の単回投与であった。rituximab治療3ヵ月で移植肺は3例(21%)で生着したが、11例(79%)で廃絶した。重篤な有害事象は11例(79%)に認められ、うち rituximabとの関連性が否定できない事象は成人3例に発現し、肺炎2例、意識変容状態が1例であった。

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  • "Hybrid Lung Transplantation" Combining Living Donor and Cadaveric Lung Transplants: Report of 2 Cases. Reviewed International journal

    Takeshi Kurosaki, Takahiro Oto, Shinji Otani, Kentaroh Miyoshi, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    Transplantation proceedings   2021.6

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    We present 2 cases of "hybrid lung transplant," which included sequentially implanting a living lobar graft to 1 side and a cadaveric graft to the other side. This procedure was approved by the institutional review board at Okayama University Hospital. The 2 recipients were diagnosed with severe idiopathic pulmonary fibrosis, and living donor lobar lung transplant was considered; however, 2 appropriate donors were not available. Therefore, we accepted extended criteria donor lungs with a partial pressure of oxygen/fraction of inspired oxygen ratio of <251 mm Hg. However, 1 of the 2 patients developed grade 2 primary graft dysfunction. The living donor lobar lung had a low volume but was in good condition, which contributed to the patient's recovery after primary graft dysfunction during the perioperative period. The other patient's status of bronchiolitis obliterans syndrome had gradually progressed to grade 3, and only the living donor lung was functioning at that time. However, both patients are alive 5.5 and 4.2 years after lung transplant, respectively. Hybrid lung transplantation may increase patients' chances of receiving transplants because patients are not likely to survive while waiting for ideal donor lungs to become available.

    DOI: 10.1016/j.transproceed.2021.04.019

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  • Current status of inhaled nitric oxide therapy for lung transplantation in Japan: a nationwide survey. Reviewed

    Nobuyuki Yoshiyasu, Masaaki Sato, Daisuke Nakajima, Yasuaki Tomioka, Yui Watanabe, Takeshi Shiraishi, Soichiro Funaki, Sumiko Maeda, Koichi Tomoshige, Takahiro Nakajima, Tomoshi Tsuchiya, Seiichiro Sugimoto, Ichiro Yoshino, Takeshi Nagayasu, Masayuki Chida, Masato Minami, Yoshinori Okada, Shinichi Toyooka, Hiroshi Date, Jun Nakajima

    General thoracic and cardiovascular surgery   69 ( 10 )   1421 - 1431   2021.5

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    OBJECTIVES: Currently, inhaled nitric oxide (NO) therapy for lung transplantation is not covered by public health insurance in Japan. In this study, we evaluated the perioperative use and safety of inhaled NO therapy for lung transplantation. METHODS: Data regarding the duration of treatment and adverse events of inhaled NO therapy were collected for all lung transplantations performed from January 1, 2015, to December 31, 2019, at nine lung transplant facilities in Japan. RESULTS: During the study period, lung transplants were performed in 357 patients, among whom inhaled NO therapy was administered to 349 patients (98%). The median initial and median maximum inhaled NO doses were 10 and 20 ppm, respectively. Inhaled NO therapy was introduced during surgery and continued postoperatively in 313 patients (90%) for a median of 4 days. Significant improvements in oxygenation and decreases in pulmonary arterial pressure were observed in patients receiving inhaled NO therapy. Side effects of inhaled NO therapy, such as methemoglobinemia, were observed in 15 patients (4%), with a significant incidence in patients aged < 18 years. CONCLUSIONS: Inhaled NO therapy was performed in almost all patients who underwent lung transplantation in Japan and showed reasonable efficacy. Therefore, public health insurance coverage for inhaled NO therapy during lung transplantation is recommended.

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  • Circulating anti-human leukocyte antigen IgM antibodies as a potential early predictor of allograft rejection and a negative clinical outcome after lung transplantation. Reviewed

    Kazuaki Miyahara, Kentaroh Miyoshi, Takeshi Kurosaki, Shinji Otani, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    Surgery today   2021.5

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    PURPOSE: Anti-human leukocyte antigen (HLA) immunoglobulin (Ig) M production stimulated by an alloantigen is sensitive, making IgM a novel potential marker of allorejection after organ transplantation. This study examined the relationship between the serum levels of anti-HLA IgM early after clinical lung transplantation (LTx) and the post-transplant outcomes. METHODS: Thirty-one consecutive patients who underwent deceased LTx were included. Immunoreactivity against HLA was retrospectively analyzed by measuring the anti-HLA IgM levels in the serum sampled for the first 14 days after LTx. The flow panel reactive antibody technique was used. The ratio of the anti-class I IgM level at each day to baseline was obtained, and the peak IgM level was determined for each case. The correlation between the peak IgM level and subsequent development of acute rejection (AR), chronic lung allograft dysfunction (CLAD), and survival outcomes were examined. RESULTS: The peak IgM level was a significant risk factor for AR within 90 days in univariate and multivariate analyses. In the long term, the patients with positive IgM (peak level > 1.8) tended to have a poorer CLAD-free and overall survival than those with negative IgM. CONCLUSION: Elevation of anti-HLA IgM levels early after LTx may be correlated with a higher incidence of rejection and negative clinical outcomes.

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  • Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Locally Advanced Non-small-cell Lung Cancer Treated with Trimodality Therapy. Reviewed International journal

    Shimpei Tsudaka, Hiromasa Yamamoto, Hiroki Sato, Kuniaki Katsui, Ken Suzawa, Kazuhiko Shien, Kentaroh Miyoshi, Shinji Otani, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Katsuyuki Kiura, Susumu Kanazawa, Shinichi Toyooka

    Annals of surgical oncology   28 ( 9 )   4880 - 4890   2021.2

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    PURPOSE: Current evidence suggests that the neutrophil-to-lymphocyte ratio (NLR) is a prognostic factor in several types of cancer. In this study, we aimed to evaluate the prognostic impact of clinicopathological factors, including postoperative NLR, in patients with locally advanced non-small-cell lung cancer (LA-NSCLC) who underwent surgery after chemoradiotherapy (CRT) with or without postoperative adjuvant chemotherapy. METHODS: The medical records of LA-NSCLC patients treated with trimodality therapy at our institution between June 1999 and May 2019 were reviewed. The association between several clinicopathological factors and overall survival (OS) was analyzed. RESULTS: A total of 168 patients were included in this study. Regarding the prognosis, the 5-year OS rate was 68.1%, and the 2-year recurrence-free survival rate was 66.1% in the entire population. In multivariate analysis, we identified that high postoperative NLR, not pretreatment or preoperative NLR, was one of the independent factors for unfavorable OS (NLR high vs NLR low; hazard ratio = 2.45, 95% confidence interval: 1.53-3.94, p < 0.001). In addition, among patients with high postoperative NLR, patients who received postoperative adjuvant chemotherapy showed significantly better 5-year OS compared with those who did not (p = 0.016). On the other hand, postoperative adjuvant chemotherapy had no impact on the prognosis in patients with low NLR (p = 0.19). CONCLUSIONS: Our results suggest that high postoperative NLR was not only an independent unfavorable prognostic factor in patients with LA-NSCLC who were treated with trimodality therapy, but also a promising indicator for postoperative treatment in this population.

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  • The prognostic nutritional index is correlated negatively with the lung allocation score and predicts survival after both cadaveric and living-donor lobar lung transplantation. Reviewed

    Haruchika Yamamoto, Seiichiro Sugimoto, Junichi Soh, Toshio Shiotani, Kentaroh Miyoshi, Shinji Otani, Mikio Okazaki, Masaomi Yamane, Shinichi Toyooka

    Surgery today   51 ( 10 )   1610 - 1618   2021.2

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    PURPOSE: The prognostic nutritional index (PNI), calculated based on the serum albumin levels and the total lymphocyte count, has been identified as a predictor of clinical outcomes in various fields of surgery. In this study, we investigated the relationship between the PNI and the lung allocation score (LAS) as well as the impact of the PNI on the outcomes of both cadaveric lung transplantation (CLT) and living-donor lobar lung transplantation (LDLLT). METHODS: We reviewed retrospective data for 127 recipients of lung transplantation (LT), including 71 recipients of CLT and 56 recipients of LDLLT. RESULTS: The PNI was correlated significantly and negatively with the LAS (r = - 0.40, P = 0.0000037). Multivariate analysis revealed that age (P = 0.00093), BMI (P = 0.00087), and PNI (P = 0.0046) were independent prognostic factors of a worse outcome after LT. In a subgroup analysis, survival after both CLT (P = 0.015) and LDLLT (P = 0.041) was significantly worse in the low PNI group than in the high PNI group. CONCLUSION: Preoperative nutritional evaluations using the PNI can assist with the assessment of disease severity in LT recipients and may predict survival after both CLT and LDLLT.

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  • The prognostic impact of sarcopenia on elderly patients undergoing pulmonary resection for non-small cell lung cancer. Reviewed

    Akihiro Miura, Hiromasa Yamamoto, Hiroki Sato, Yasuaki Tomioka, Toshio Shiotani, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    Surgery today   51 ( 7 )   1203 - 1211   2021.2

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    PURPOSE: The number of elderly patients who undergo surgery is increasing, even though they are at a high risk due to a decreased physical strength. Furthermore, sarcopenia is generally associated with a poor prognosis in patients with non-small cell lung cancer (NSCLC). METHODS: This study included NSCLC patients  ≥ 65 years old who underwent pulmonary resection in our hospital between 2012 and 2015. Sarcopenia was assessed using the psoas muscle mass index based on computed tomography at the level of the third lumbar vertebra. We elucidated the impact of sarcopenia on short- and long-term outcomes after surgery. RESULTS: We enrolled 259 patients, including 179 with sarcopenia. Patients with sarcopenia before surgery tended to have postoperative complications (p = 0.0521), although they did not show a poor prognosis. In patients with sarcopenia, a multivariate analysis revealed that postoperative complications and the progression of sarcopenia 1 year after surgery were significant risk factors for a poor prognosis (p = 0.0169 and 0.00370, respectively). CONCLUSIONS: The progression of sarcopenia after surgery is associated with a poor prognosis in elderly NSCLC patients with sarcopenia. A strategy to prevent postoperative progressive sarcopenia may be necessary for improving the clinical outcome of this population.

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  • Successful Bronchoscopic Treatment for Postoperative Bronchopleural Fistula Using N-butyl-2-cyanoacrylate (NBCA): Report of a Post-completion Pneumonectomy Case with a History of Induction Chemoradiotherapy Followed by Bilobectomy for Advanced Lung Cancer. Reviewed

    Toshio Shiotani, Hiromasa Yamamoto, Riko Katsube, Yasuaki Tomioka, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Mikio Okazaki, Seiichiro Sugimoto, Junichi Soh, Masaomi Yamane, Shinichi Toyooka

    Acta medica Okayama   75 ( 1 )   91 - 94   2021.2

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    Bronchopleural fistula (BPF) is a severe complication following lung resection. We present the case of a patient with a history of advanced lung cancer, who had undergone induction chemoradiotherapy followed by right middle and lower lobectomy, and who developed BPF after completion right pneumonectomy. Although we had covered the bronchial stump with an omental pedicled flap, BPF was found on postoperative day 19. We covered the fistula with n-butyl-2-cyanoacrylate (NBCA) using bronchoscopy. Although we had to repeat the NBCA treatment, we ultimately cured the patient's BPF and no recurrence was observed up to 15.2 months after surgery.

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  • Long-term Follow-up of Living-Donor Kidney Transplantation after Cadaveric Lung Transplantation. Reviewed

    Toshio Shiotani, Seiichiro Sugimoto, Kota Araki, Yasuaki Tomioka, Kentaroh Miyoshi, Shinji Otani, Masaomi Yamane, Shinichi Toyooka

    Acta medica Okayama   75 ( 1 )   87 - 89   2021.2

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    Although chronic kidney disease (CKD) commonly develops after lung transplantation (LT), living-donor kid-ney transplantation (LDKT) for CKD after LT is known to provide favorable outcomes. We describe the long-term follow-up findings of a patient who underwent LDKT after bilateral cadaveric LT. A 37-year-old male underwent LDKT for CKD 18 years after receiving bilateral cadaveric LT. He developed chronic lung allograft dysfunction (CLAD) 20 years after the LT; however, at 26 years after the initial LT, he is still alive with no pro-gression of CLAD or CKD. KT could be a viable option for CKD even after LT in Japan.

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  • Staged surgery for empyema and lung gangrene caused by pseudoaneurysm after radiofrequency ablation. Reviewed International journal

    Kentaro Nakata, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    Interactive cardiovascular and thoracic surgery   32 ( 5 )   831 - 833   2021.1

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    Lung gangrene is a potentially fatal disease, and primary or staged surgery, depending on the patient's condition, is reported to be useful. We describe successful management, by staged surgery, of a rare case of empyema and lung gangrene complicating lung radiofrequency ablation. The patient, who was a diabetic with colorectal pulmonary metastases, underwent embolization of a pulmonary artery pseudoaneurysm in the right basal segment that developed after lung radiofrequency ablation. He subsequently developed lung gangrene caused by lung ischaemia, and empyema, necessitating pleural decortication followed by open-window thoracostomy. Subsequently, right basal segmentectomy was performed, with thoracostoma closure. Staged surgery might be beneficial for high-risk patients with empyema and lung gangrene caused by lung ischaemia.

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  • The heterodimer S100A8/A9 is a potent therapeutic target for idiopathic pulmonary fibrosis. Reviewed International journal

    Kota Araki, Rie Kinoshita, Nahoko Tomonobu, Yuma Gohara, Shuta Tomida, Yuta Takahashi, Satoru Senoo, Akihiko Taniguchi, Junko Itano, Ken-Ichi Yamamoto, Hitoshi Murata, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Kouichi Ichimura, Masahiro Nishibori, Nobuaki Miyahara, Shinichi Toyooka, Masakiyo Sakaguchi

    Journal of molecular medicine (Berlin, Germany)   99 ( 1 )   131 - 145   2021.1

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    In patients with interstitial pneumonia, pulmonary fibrosis is an irreversible condition that can cause respiratory failure. Novel treatments for pulmonary fibrosis are necessary. Inflammation is thought to activate lung fibroblasts, resulting in pulmonary fibrosis. Of the known inflammatory molecules, we have focused on S100A8/A9 from the onset of inflammation to the subsequent progression of inflammation. Our findings confirmed the high expression of S100A8/A9 in specimens from patients with pulmonary fibrosis. An active role of S100A8/A9 was demonstrated not only in the proliferation of fibroblasts but also in the fibroblasts' differentiation to myofibroblasts (the active form of fibroblasts). S100A8/A9 also forced fibroblasts to upregulate the production of collagen. These effects were induced via the receptor of S100A8/A9, i.e., the receptor for advanced glycation end products (RAGE), on fibroblasts. The anti-S100A8/A9 neutralizing antibody inhibited the effects of S100A8/A9 on fibroblasts and suppressed the progression of fibrosis in bleomycin (BLM)-induced pulmonary fibrosis mouse model. Our findings strongly suggest a crucial role of S100A8/A9 in pulmonary fibrosis and the usefulness of S100A8/A9-targeting therapy for fibrosis interstitial pneumonia. HIGHLIGHTS: S100A8/A9 level is highly upregulated in the IPF patients' lungs as well as the blood. S100A8/A9 promotes not only the growth of fibroblasts but also differentiation to myofibroblasts. The cell surface RAGE acts as a crucial receptor to the extracellular S100A8/A9 in fibroblasts. The anti-S100A8/A9 antibody effectively suppresses the progression of IPF in a mouse model. In idiopathic pulmonary fibrosis (IPF), S100A8/A9, a heterodimer composed of S100A8 and S100A9 proteins, plays a crucial role in the onset of inflammation and the subsequent formation of a feed-forward inflammatory loop that promotes fibrosis. (1) The local, pronounced increase in S100A8/A9 in the injured inflammatory lung region-which is provided mainly by the activated neutrophils and macrophages-exerts strong inflammatory signals accompanied by dozens of inflammatory soluble factors including cytokines, chemokines, and growth factors that further act to produce and secrete S100A8/A9, eventually making a sustainable inflammatory circuit that supplies an indefinite presence of S100A8/A9 in the extracellular space with a mal-increased level. (2) The elevated S100A8/A9 compels fibroblasts to activate through receptor for advanced glycation end products (RAGE), one of the major S100A8/A9 receptors, resulting in the activation of NFκB, leading to fibroblast mal-events (e.g., elevated cell proliferation and transdifferentiation to myofibroblasts) that actively produce not only inflammatory cytokines but also collagen matrices. (3) Finally, the S100A8/A9-derived activation of lung fibroblasts under a chronic inflammation state leads to fibrosis events and constantly worsens fibrosis in the lung. Taken together, these findings suggest that the extracellular S100A8/A9 heterodimer protein is a novel mainstay soluble factor for IPF that exerts many functions as described above (1-3). Against this background, we herein applied the developed S100A8/A9 neutralizing antibody to prevent IPF. The IPF imitating lung fibrosis in an IPF mouse model was effectively blocked by treatment with the antibody, leading to enhanced survival. The developed S100A8/A9 antibody, as an innovative novel biologic, may help shed light on the difficulties encountered with IPF therapy in clinical settings.

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  • 外科系新専門医制度のあるべきグランドデザイン 地域枠医師に対する外科専門研修のあり方 充実した地域医療の実現を目指して

    黒田 新士, 吉田 龍一, 池田 宏国, 岡崎 幹生, 大澤 晋, 小谷 恭弘, 山根 正修, 杉本 誠一郎, 菊地 覚次, 安井 和也, 野田 卓男, 笠原 真悟, 豊岡 伸一, 土井原 博義, 藤原 俊義

    日本外科学会雑誌   122 ( 1 )   83 - 85   2021.1

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  • Prognostic nutrition index affects the prognosis of patients undergoing trimodality therapy for locally advanced non-small cell lung cancer. Reviewed

    Junichi Soh, Ken Suzawa, Kazuhiko Shien, Shinji Otani, Hiromasa Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Kuniaki Katsui, Masaomi Yamane, Katsuyuki Kiura, Susumu Kanazawa, Shinichi Toyooka

    Surgery today   50 ( 12 )   1610 - 1618   2020.12

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    PURPOSE: Trimodality therapy, comprised of induction chemoradiotherapy (iCRT) followed by surgery, is a highly invasive treatment option for locally advanced non-small cell lung cancers (LA-NSCLCs; defined as a heterogenous disease). We conducted this study to investigate the prognostic nutritional index (PNI) of LA-NSCLC patients undergoing trimodality therapy, which has not been studied in detail before. METHODS: The subjects of this retrospective study were 127 patients who underwent trimodality therapy between 1999 and 2016. We measured the PNI at three points: before iCRT (pre-iCRT), before the operation, and after the operation. RESULTS: PNIs decreased significantly as treatment progressed. Patients with clinical T3/4 (cT3/4) disease had a significantly lower PNI than those with cT1/2 disease, but the extent of lymph-node metastasis did not affect the PNI at any point. Using the cut-off values of receiver-operating curve analyses, multivariable analyses revealed that a high PNI pre-iCRT correlated significantly with a better survival of LA-NSCLC patients, especially those with cT3/4 disease (hazard ratio 3.84; 95% confidential interval 1.34-12.5, P = 0.012). CONCLUSIONS: Measuring the PNI before trimodality therapy is important for predicting the clinical outcome of patients with LA-NSCLC, with differing predictive ability according to the disease extent. Perioperative intensive nutritional intervention must be considered for patients who undergo trimodality therapy for LA-NSCLC.

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  • A Simple Prognostic Benefit Scoring System for Sarcoma Patients with Pulmonary Metastases: Sarcoma Lung Metastasis Score. Reviewed International journal

    Haruchika Yamamoto, Hiromasa Yamamoto, Junichi Soh, Etsuji Suzuki, Kei Namba, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Takashi Yorifuji, Katsuhito Takahashi, Shinichi Toyooka

    Annals of surgical oncology   28 ( 7 )   3884 - 3890   2020.11

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    BACKGROUND: Pulmonary metastasectomy could be considered one of the treatment options for disease control in sarcoma patients with pulmonary metastases; however, there is little consensus regarding the suitable criteria for predicting the likely outcomes in these patients. The aim of this study was to establish a prognostic benefit scoring system based on preoperatively examined prognostic factors for sarcoma patients with pulmonary metastases. METHODS: This was a single-center, retrospective cohort study conducted in a cohort of 135 sarcoma patients who underwent a first pulmonary metastasectomy at Okayama University Hospital between January 2006 and December 2015. Based on the results of a multivariable logistic regression analysis performed to determine the factors influencing 3-year mortality, a Sarcoma Lung Metastasis Score was created and its correlation with 3-year survival was analyzed. RESULTS: The results of the multivariate analysis revealed significant differences in the disease-free interval (< 2 years vs. ≥ 2 years; odds ratio (OR) 4.22, 95% confidence interval (CI) 1.67-10.70), maximum tumor diameter (≥ 15 mm vs. < 15 mm; OR 3.86, 95% CI 1.75-8.52), and number of pulmonary metastases (≥ 6 vs. < 6; OR 2.65, 95% CI 1.06-6.620). The Sarcoma Lung Metastasis Score, which was defined as the total score of these three factors, reliably predicted 3-year survival (score: 0, 89.5%; 1, 63.2%; 2, 39.0%; 3, 10.5%). CONCLUSIONS: Our newly proposed simple Sarcoma Lung Metastasis Score appears to be a useful prognostic predictor for sarcoma patients with pulmonary metastases, in that it could be helpful for the selection of appropriate treatments for these patients.

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  • Long-term clinical follow-up after lung transplantation in patient with scoliosis: a case report. Reviewed

    Haruchika Yamamoto, Shinji Otani, Kentaroh Miyoshi, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    General thoracic and cardiovascular surgery   69 ( 4 )   752 - 755   2020.11

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    Severe scoliosis causes anatomical distortion of structures in the chest, which raises concerns about donor-recipient size-mismatch in lung transplantation (LT), so that severe scoliosis is considered as an absolute contraindication for LT. Also, postoperative right-side bronchial stenosis is one of the common complications in LT recipients with severe scoliosis. To date, the long-term outcomes in severe scoliosis patients with bronchial stenosis after LT have not been reported. A 14-year-old female patient with scoliosis and interstitial pneumonia underwent bilateral cadaveric LT. Although she developed bronchial stenosis post-LT, necessitating bronchoscopic intervention on three occasions, her lung function and perfusion recovered to the levels recorded prior to development of the obstruction, with the good condition maintained for more than 5 years after the LT. Therefore, while patients with severe scoliosis are at an elevated risk of postoperative transient bronchial stenosis, scoliosis should not always be considered as a contraindication to LT.

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  • Chronic lung injury after trimodality therapy for locally advanced non-small cell lung cancer. Reviewed International journal

    Junichi Soh, Seiichiro Sugimoto, Kei Namba, Akihiro Miura, Toshio Shiotani, Haruchika Yamamoto, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Mikio Okazaki, Kuniaki Katsui, Masaomi Yamane, Katsuyuki Kiura, Susumu Kanazawa, Shinichi Toyooka

    The Annals of thoracic surgery   112 ( 1 )   279 - 288   2020.10

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    BACKGROUND: Trimodality therapy is a treatment option for patients with locally advanced non-small cell lung cancer (LA-NSCLC). Thoracic radiation has both early (radiation pneumonitis) and late (chronic lung injury: CLI) adverse effects on the lung. While CLI is expected to result in various problems in long-term survivors, these manifestations have not been precisely investigated. METHODS: We enrolled 112 LA-NSCLC patients who had received induction chemoradiotherapy followed by surgery, and then undergone follow-up computed tomography (CT) every 6 months for >1 year. All chest CT images were reviewed to evaluate any injury of the pulmonary parenchyma. RESULTS: CLI at 1 year after surgery and its progression (pCLI) were observed in 94 (84%) and 38 (34%) patients, respectively. Progressive lung fibrosis (PLF) as the first manifestation of pCLI was most frequent after right middle and/or lower lobectomy. Cavity formation was the subsequent manifestation after PLF, and chronic infection was the final stage of CLI. The cumulative rate of chronic infection was 76.4% at 10 years in patients with cavity formation. Ten patients with chronic infection included seven cases of pulmonary aspergillosis and two cases of cavity infections with methicillin-resistant Staphylococcus aureus or Stenotrophomonas maltophili. Among them, 4 patients required surgical interventions including completion pneumonectomy or fenestration. CONCLUSIONS: CLI is a common incidence after trimodality therapy for LA-NSCLC. CLI frequently results in cavity formation, which is a precursor of highly refractory chronic infections requiring surgical intervention. Appropriate management needs to be established for CLI developing after trimodality therapy.

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  • Lung transplantation for Kartagener syndrome: technical aspects and morphological adaptation of the transplanted lungs. Reviewed

    Haruchika Yamamoto, Seiichiro Sugimoto, Kentaroh Miyoshi, Shinji Otani, Masaomi Yamane, Shinichi Toyooka

    General thoracic and cardiovascular surgery   69 ( 3 )   588 - 592   2020.10

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    While technical considerations in lung transplantation for Kartagener syndrome have been discussed, little information is available about the postoperative morphological changes of the grafted lungs. Herein, we discuss both the technical aspects and postoperative morphological adaptation of the grafted lungs in a case of Kartagener syndrome. A 46-year-old male patient with Kartagener syndrome underwent bilateral cadaveric lung transplantation. The right arterial anastomosis for transplantation of the size-matched grafts required technical elaboration. After the transplantation, we found a free space in the cardiac notch of the left lung and partial collapse of the lower lobe of the right lung due to dextrocardia. Follow-up computed tomography performed on day 42 after the transplantation demonstrated resolution of the atelectasis and morphological adaptation of the grafts into the recipient's chest cavity with dextrocardia. Considering such early morphological adaptation of size-matched grafts, lobar reduction could be avoided in lung transplantation for Kartagener syndrome.

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  • A Giant Thymic Cyst Accompanied by Acute Mediastinitis. Reviewed

    Akihiro Miura, Kazuhiko Shien, Tomohiro Toji, Shinji Otani, Hiromasa Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Junichi Soh, Masaomi Yamane, Shinichi Toyooka

    Acta medica Okayama   74 ( 5 )   431 - 433   2020.10

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    We encountered a rare case of thymic cyst accompanied by mediastinitis. A 39-year-old Japanese male presented with fever and chest pain. The chest CT revealed a mass composed of a lobular cystic lesion with inflammation, suggesting the onset of mediastinitis. A definitive histological diagnosis was not obtained, and we performed a thymectomy. Pathologically, the thymic cyst was accompanied by multiple cavities, mimicking thymic cysts, caused by the inflammatory abscess. The surrounding adipose tissue showed inflammatory cell infiltrations with chronic fibrosis. These findings indicate that clinicians should be aware that thymic cysts may cause severe mediastinitis.

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  • Continuing surgical education of non-technical skills. Reviewed International journal

    Masaomi Yamane, Seiichiro Sugimoto, Etsuji Suzuki, Keiju Aokage, Mikio Okazaki, Junichi Soh, Makio Hayama, Yuji Hirami, Takashi Yorifuji, Shinichi Toyooka

    Annals of medicine and surgery (2012)   58   177 - 186   2020.10

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    Background: The non-technical skills for surgeons (NOTSS) system was developed as a tool to assess surgical skills for patient safety during surgery. This study aimed to develop a NOTSS-based training system for surgical trainees to acquire non-technical skills using a chest surgery scenario in a wet lab. Materials and methods: Trainees were categorized into three subgroups according to the years of experience as follows: Level A: 6 years or more; Level B: 3-5 years; and Level C: 1-2 years. Three stages of surgical procedure were designed: 1. chest wall resection and right upper lobe lobectomy, 2. right middle lobe sleeve lobectomy, and 3. right lower lobe lobectomy. One instructor was assigned to each operation table, who evaluated each participant's NOTSS scores consisting of 16 elements. Results: When comparing average NOTSS score of all the three procedures, significant differences were observed between Level A, B, and C trainees. As an example of varying elements by procedure, Level A trainees demonstrated differences in Situation Awareness, and a significant difference was observed in Level C trainees regarding the elements of Decision Making. On the contrary, no significant difference was observed among Level B trainees. In the comparison between first-time and experienced participants, a significant improvement was observed in some elements in Level B and C trainees. Conclusion: This study highlights the usefulness and feasibility of the NOTSS scoring system for surgeons with different experiences and the effectiveness of providing feedback to trainees during intraoperative handoffs in a wet lab.

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  • Effectiveness of scheduled intravenous acetaminophen in the postoperative pain management of video-assisted thoracic surgery. Reviewed

    Yoshinobu Shikatani, Junichi Soh, Kazuhiko Shien, Takeshi Kurosaki, Shinji Ohtani, Hiromasa Yamamoto, Arata Taniguchi, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Takahiro Oto, Hiroshi Morimatsu, Shinichi Toyooka

    Surgery today   51 ( 4 )   589 - 594   2020.9

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    PURPOSE: The scheduled administration of intravenous acetaminophen (scheduled-IV-AcA) is one of the more effective multimodal analgesic approaches for postoperative pain in abdominal/orthopedic surgeries. However, there is little evidence concerning scheduled-IV-AcA after general thoracic surgery, especially when limited to video-assisted thoracoscopic surgery (VATS). We investigated the efficacy of scheduled-IV-AcA administration in patients after undergoing VATS. METHODS: Ninety-nine patients who underwent VATS lobectomy or segmentectomy via an 8-cm access window and 1 camera port were retrospectively reviewed by categorizing them into groups either with scheduled-IV-AcA (Group AcA: n = 29) or without it (Group non-AcA: n = 70). Group AcA received 1 g of IV-AcA every 6 h from the end of the operation until the end of POD2. Postoperative pain was measured using a numeric rating scale (NRS) three times per day until discharge. RESULTS: NRS scores were significantly lower in Group AcA with motion (on POD1 to the first point of POD2) than in Group non-AcA. Group non-AcA was also more likely to use additional analgesics than Group AcA (39% vs. 17%, p = 0.058). CONCLUSIONS: Scheduled-IV-AcA administration is a safe and effective multimodal analgesic approach in patients undergoing VATS pulmonary resection via an 8-cm access window.

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  • Overcoming epithelial-mesenchymal transition-mediated drug resistance with monensin-based combined therapy in non-small cell lung cancer. Reviewed International journal

    Kosuke Ochi, Ken Suzawa, Shuta Tomida, Kazuhiko Shien, Jui Takano, Shunsaku Miyauchi, Tatsuaki Takeda, Akihiro Miura, Kota Araki, Kentaro Nakata, Hiromasa Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Tadahiko Shien, Masaomi Yamane, Kazuo Azuma, Yoshiharu Okamoto, Shinichi Toyooka

    Biochemical and biophysical research communications   529 ( 3 )   760 - 765   2020.8

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    BACKGROUND: The epithelial-mesenchymal transition (EMT) is a key process in tumor progression and metastasis and is also associated with drug resistance. Thus, controlling EMT status is a research of interest to conquer the malignant tumors. MATERIALS AND METHODS: A drug repositioning analysis of transcriptomic data from a public cell line database identified monensin, a widely used in veterinary medicine, as a candidate EMT inhibitor that suppresses the conversion of the EMT phenotype. Using TGF-β-induced EMT cell line models, the effects of monensin on the EMT status and EMT-mediated drug resistance were assessed. RESULTS: TGF-β treatment induced EMT in non-small cell lung cancer (NSCLC) cell lines and the EGFR-mutant NSCLC cell lines with TGF-β-induced EMT acquired resistance to EGFR-tyrosine kinase inhibitor. The addition of monensin effectively suppressed the TGF-β-induced-EMT conversion, and restored the growth inhibition and the induction of apoptosis by the EGFR-tyrosine kinase inhibitor. CONCLUSION: Our data suggested that combined therapy with monensin might be a useful strategy for preventing EMT-mediated acquired drug resistance.

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  • The neutrophil-to-lymphocyte ratio as a novel independent prognostic factor for multiple metastatic lung tumors from various sarcomas. Reviewed

    Hiromasa Yamamoto, Kei Namba, Haruchika Yamamoto, Tomohiro Toji, Junichi Soh, Kazuhiko Shien, Ken Suzawa, Takeshi Kurosaki, Shinji Otani, Mikio Okazaki, Seiichiro Sugimoto, Masaomi Yamane, Katsuhito Takahashi, Toshiyuki Kunisada, Takahiro Oto, Shinichi Toyooka

    Surgery today   51 ( 1 )   127 - 135   2020.8

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    PURPOSE: Sarcomas are among the most refractory malignant tumors and often recur as pulmonary metastasis. Although the presence of a high neutrophil-to-lymphocyte ratio (NLR) has been associated with the prognosis of several malignancies, the relationship between the NLR and sarcoma with pulmonary metastasis is unclear. We investigated the impact of the NLR in patients who underwent surgical resection for metastatic lung tumors from various sarcomas. METHODS: The subjects of this retrospective study were 158 patients with metastatic lung tumors from various sarcomas, who underwent initial pulmonary metastasectomy between 2006 and 2015. We examined the clinicopathological variables, including the NLR and the characteristics of surgical procedures. Survival was estimated by the Kaplan-Meier method and prognostic factors were evaluated by multivariate analysis. RESULTS: Multivariate analysis revealed significantly better survival of the group with an NLR < 2.26 immediately before the most recent pulmonary metastasectomy, in addition to such factors as the largest resected lesion being < 22 mm, a disease-free interval of > 2 years, and 3 or more pulmonary metastasectomies. CONCLUSION: The NLR immediately before the most recent pulmonary metastasectomy is a novel independent prognostic factor, which may be helpful when considering repeated pulmonary metastasectomy.

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  • Lung perfusion scintigraphy to detect chronic lung allograft dysfunction after living-donor lobar lung transplantation. Reviewed International journal

    Haruchika Yamamoto, Seiichiro Sugimoto, Takeshi Kurosaki, Kentaroh Miyoshi, Shinji Otani, Mikio Okazaki, Masaomi Yamane, Takahiro Oto, Shinichi Toyooka

    Scientific reports   10 ( 1 )   10595 - 10595   2020.6

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    Because chronic lung allograft dysfunction (CLAD) develops predominantly on one side after bilateral living-donor lobar lung transplantation (LDLLT), lung perfusion scintigraphy (Q-scinti) was expected to show a perfusion shift to the contralateral unaffected lung with the development of CLAD. Our study examined the potential usefulness of Q-scinti in the diagnosis of CLAD after bilateral LDLLT. We conducted a single-center retrospective cohort study of 58 recipients of bilateral LDLLT. The unilateral shift values on Q-scinti were calculated and compared between the CLAD group (N = 27) and the non-CLAD group (N = 31) from 5 years before to 5 years after the diagnosis of CLAD. The unilateral shift values in Q-scinti were significantly higher in the CLAD group than in the non-CLAD group from 5 years before the diagnosis of CLAD to 5 years after the diagnosis (P < 0.05). The unilateral shift values in Q-scinti were significantly correlated with the percent baseline values of the forced expiratory volume in 1 s (P = 0.0037), the total lung capacity (P = 0.0028), and the forced vital capacity (P = 0.00024) at the diagnosis of CLAD. In patients developing unilateral CLAD after bilateral LDLLT, Q-scinti showed a unilateral perfusion shift to the contralateral unaffected lung. Thus, Q-scinti appears to have the potential to predict unilateral CLAD after bilateral LDLLT.

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  • Right single lung transplantation using an inverted left donor lung: interposition of pericardial conduit for pulmonary venous anastomosis - a case report. Reviewed International journal

    Haruchika Yamamoto, Kentaroh Miyoshi, Shinji Otani, Takeshi Kurosaki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka, Motomu Kobayashi, Takahiro Oto

    BMC pulmonary medicine   20 ( 1 )   46 - 46   2020.2

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    BACKGROUND: Lung transplantation (LTx) is still limited by the shortage of suitable donor lungs. Developing flexible surgical procedures can help to increase the chances of LTx by unfolding recipient-to-donor matching options based on the pre-existing organ allocation concept. We report a case in which a successful left-to-right inverted LTx was completed using the interposition of a pericardial conduit for pulmonary venous anastomosis. CASE PRESENTATION: A left lung graft was offered to a 59-year-old male who had idiopathic pulmonary fibrosis with predominant damage in the right lung. He had been prescribed bed rest with constant oxygen inhalation through an oxymizer pendant and had been on the waiting list for 20 months. Considering the condition of the patient (LAS 34.3) and the scarcity of domestic organ offers, the patient was highly likely to be incapable of tolerating any additional waiting time for another donor organ if he was unable to accept the presently reported offer of a left lung. Eventually, we decided to transplant the left donor lung into the right thorax of the recipient. Because of the anterior-posterior position gap of the hilar structures, the cuff lengths of the pulmonary veins had to be adjusted. The patient did not develop any anastomotic complications after the transplantation. CONCLUSIONS: A left-to-right inverted LTx is technically feasible using an autologous pericardial conduit for pulmonary venous anastomosis in selected cases. This technique provides the potential benefit of resolving challenging situations in which surgeons must deal with a patient's urgency and the logistical limitations of organ allocation.

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  • Pulmonary aspergillosis as a late complication after surgery for locally advanced non-small cell lung cancer treated with induction chemoradiotherapy. Reviewed

    Seiichiro Sugimoto, Junichi Soh, Ken Suzawa, Kentaroh Miyoshi, Shinji Otani, Hiromasa Yamamoto, Mikio Okazaki, Masaomi Yamane, Takahiro Oto, Susumu Kanazawa, Katsuyuki Kiura, Shinichi Toyooka

    Surgery today   50 ( 8 )   863 - 871   2020.1

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    PURPOSE: Some long-term survivors after surgery for locally advanced non-small cell lung cancer (NSCLC) treated with induction chemoradiotherapy (trimodality treatment) develop chronic pulmonary aspergillosis (CPA). The aim of our study was to assess the characteristics and outcomes of CPA that develops after trimodality treatment. METHODS: We retrospectively reviewed the data of 187 NSCLC patients who underwent trimodality treatment between 1999 and 2018. RESULTS: Six male ever-smoker patients developed CPA. All 6 patients had undergone extended resection for NSCLC and had a history of either adjuvant chemotherapy (n = 3) or radiation pneumonitis (n = 4). Among the 4 patients with CPA localized in a single lung, 3 patients were treated surgically (completion pneumonectomy or cavernostomy) and 1 patient was treated with antifungal therapy alone. Both treatments led to the improved control of CPA. In contrast, patients with CPA in both lungs were not candidates for surgery, and died of CPA. The survival rates after trimodality treatment in the CPA group and the group without CPA were comparable (10-year survival rate, 50.0% vs. 57.6%, P = 0.59). CONCLUSION: The early diagnosis of CPA localized in a single lung after NSCLC surgery is critical to improving control and survival in patients with CPA.

    DOI: 10.1007/s00595-020-01960-5

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  • Negative impact of recipient SPRED2 deficiency on transplanted lung in a mouse model. Reviewed International journal

    Hashimoto K, Yamane M, Sugimoto S, Hirano Y, Kurosaki T, Otani S, Miyoshi K, Ohara T, Okazaki M, Yoshimura T, Oto T, Matsukawa A, Toyooka S

    Transplant immunology   57   101242 - 101242   2019.12

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    Ischemia-reperfusion injury (IRI) after lung transplantation mainly contributes to the development of primary graft dysfunction. The Sprouty-related EVH1-domain-containing (SPRED) protein family inhibits the mitogen activated protein kinase/extracellular-signal-regulated kinase (MAPK/ERK) pathway. Our study was aimed at examining the role of SPRED2 in IRI in mice that received orthotopic lung transplantation. Syngeneic mouse lung transplantation was performed in wild-type C57BL/6 J (WT) mice and Spred2 knockout (Spred2-/-) mice on the C57BL/6 J background from the WT donor. Four hours after reperfusion, blood gas analysis was performed, and lung grafts were sacrificed and analyzed. By using arterial oxygen tension measurements and histological evaluation using Lung Injury Score, we revealed more severe IRI in the grafts transplanted to Spred2-/- recipients, which manifested as exacerbated airway epithelial cell damage, interstitial edema with hemorrhage and neutrophil infiltration. Intragraft ERK1/2 activation and expression levels of proinflammatory cytokines and chemokines in Spred2-/- recipients were higher than those in WT recipients. SPRED2 plays an important role in protecting the lungs from IRI in lung transplantation recipients. We suggest that focused treatments suppressing the activity of the MAPK/ERK pathway in transplantation recipients could be the potential therapeutic option for the prevention of lung IRI.

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  • Airway bacteria of the recipient but not the donor are relevant to post-lung transplant pneumonia. Reviewed

    Konishi Y, Miyoshi K, Kurosaki T, Otani S, Sugimoto S, Yamane M, Oto T, Toyooka S

    General thoracic and cardiovascular surgery   68 ( 8 )   833 - 840   2019.12

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    BACKGROUND: Optimal management of early airway infection is essential for the survival of lung transplant (LTx) recipients during the first 12 months after transplantation. This study aimed to explore the main cause of post-lung transplant pneumonia (PLTP) within 30 days after LTx. METHODS: Forty LTx patients were retrospectively analyzed. Sputum sampling from donors' and recipients' airways was performed pretransplant and posttransplant daily for the first 30 days after LTx. Organisms in the recipient's and donor's original airways were compared to pathogens responsible for PLTP. Patients with and without PLTP were also compared to identify relevant risk factors. RESULTS: Seventeen (42.5%) patients developed pneumonia (PLTP group) and 23 had no episode of pneumonia (Non-PLTP group) during the first 30 days. In the PLTP group, median time from LTx to PLTP onset was 6 days. A significantly higher incidence of PLTP was caused by recipient's rather than donor's original airway bacteria (62% vs 13%, p < 0.01). Smoking history of the donor and pretransplant airway bacterial colonization of the recipient were independent risk factors of PLTP which was associated with prolonged posttransplant mechanical ventilation with longer intensive care unit stay and worse survival outcomes. CONCLUSIONS: The recipient's original airway microflora rather than the donor's, was highly associated with PLTP. A combination of donor smoking history and recipient airway infection should be avoided, while evidence of donor lung infection is not a contraindication for LTx.

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  • N2非小細胞肺癌に対する外科治療 Invited Reviewed

    杉本 誠一郎, 豊岡 伸一

    肺癌   59 ( 7 )   1129 - 1133   2019.12

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:(NPO)日本肺癌学会  

    N2陽性の非小細胞肺癌では、局所の制御を目的とした放射線治療や手術と、遠隔転移の制御を目的とした化学療法を組み合わせた集学的治療が行われてきた。N2非小細胞肺癌に対する導入療法後手術の有用性が示唆されていたが、第III相試験では、根治的化学放射線療法と比較した導入療法後手術の優越性は証明されていないのが現状である。しかし、切除可能なN2非小細胞肺癌で、特に肺葉切除術が可能な場合には、導入化学放射線療法後の手術の有用性が示唆されており、治療の選択肢として考慮すべきである。また、最近では新しい治療薬として免疫チェックポイント阻害剤が登場し、切除不能III期非小細胞肺癌に対して、化学放射線療法との逐次併用による有用性が示され、治療の選択肢が増えている。本稿では、N2非小細胞肺癌に対する導入療法後手術の臨床試験を概説し、当院における導入放射線化学療法後手術の周術期管理や手術の工夫を述べるとともに、今後の展望について述べる。(著者抄録)

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  • Twenty-year Follow-up of the First Bilateral Living-donor Lobar Lung Transplantation in Japan.

    Masamichi Komatsu, Hiroshi Yamamoto, Toshitaka Shomura, Kei Sonehara, Takashi Ichiyama, Kazuhisa Urushihata, Atsuhito Ushiki, Masanori Yasuo, Toshihide Wakamatsu, Seiichiro Sugimoto, Takahiro Oto, Hiroshi Date, Tomonobu Koizumi, Masayuki Hanaoka, Keishi Kubo

    Internal medicine (Tokyo, Japan)   58 ( 21 )   3133 - 3137   2019.11

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    Patients with end-stage lung disease can undergo living-donor lobar lung transplantation (LDLLT), with survival rates improving every year. We herein report the 20-year follow-up findings of the first patient who underwent LDLLT in Japan. A 24-year-old woman with primary ciliary dyskinesia became ventilator-dependent after severe respiratory failure and right-sided heart failure following repeated respiratory infections. In 1998, she underwent LDLLT and received her sister's right lower lobe and her mother's left lower lobe. Although the patient required 21 hospitalizations and developed unilateral bronchiolitis obliterans syndrome, she is in good physical condition and lives without restriction at 20 years after undergoing LDLLT.

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  • Favorable survival even with high disease-specific complication rates in lymphangioleiomyomatosis after lung transplantation - long-term follow-up of a Japanese center. Reviewed International journal

    Kurosaki T, Otani S, Miyoshi K, Okazaki M, Sugimoto S, Suno M, Yamane M, Kobayashi M, Oto T, Toyooka S

    The clinical respiratory journal   14 ( 2 )   116 - 123   2019.11

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    BACKGROUND: Lung transplantation (LT) is a reliable therapeutic option for end-stage pulmonary lymphangioleiomyomatosis (LAM). Long-term outcome of LAM recipients after LT remains unknown. The aim of this study was to describe the outcomes of LT for LAM with a long-term follow-up, comparing those for other diseases in the same period. METHODS: We retrospectively reviewed consecutive 145 LT recipients between 1998 and 2015 at Okayama University Hospital with minimum 3-year follow-up. RESULTS: Twelve LAM recipients including nine sporadic-LAM and three tuberous sclerosis complex -LAM were identified. Nine of 12 underwent bilateral LT including four living-donor lobar LT. There was no significant difference in overall survival between the two groups. (P = 0.15). Chronic lung allograft dysfunction free survival rate in LAM compared with other diseases tended to be better (P = 0.058). However, the rate of requiring hemodialysis was significantly higher in LAM recipients than in the recipients of other diseases (P = 0.047). Notably, 8 of 12 (67%) LAM patients encountered LAM-related complication including chylothorax and pneumothorax, seven (58%) had proliferative diseases consisting of renal angiomyolipoma and recurrent LAM. Nine patients required mTOR inhibitors for LAM-related problems, contributing to improved control of LAM-related problems. While all nine recipients of bilateral LT have still survived, two patients died of diseases in their native lungs and one required re-LT among three recipients of single LT. CONCLUSION: Although the rates of LAM-related complications were unexpectedly high in the long term, LT is a feasible therapeutic option for patients with advanced pulmonary LAM.

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  • Warm retrograde perfusion can remove more fat from lung grafts with fat embolism in a porcine model. Reviewed

    Irie M, Otani S, Kurosaki T, Tanaka S, Ohki T, Miyoshi K, Sugimoto S, Yamane M, Oto T, Toyooka S

    General thoracic and cardiovascular surgery   68 ( 4 )   363 - 369   2019.11

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    OBJECTIVE: In lung transplantation, unexpected pulmonary emboli, including thrombi and fat, have been observed with high probability and are associated with potential primary graft dysfunction. We evaluated a new perfusion method using warm retrograde flushing that removes more fat than conventional cold retrograde flushing. METHODS: We developed a novel porcine donor model for pulmonary fat embolism by administering autologous fat in the left pulmonary artery. The left pulmonary artery and the left superior and inferior pulmonary veins were cannulated for flushing and collecting these solutions. After flushing, the left lung was reperfused under observation for 3 h. Two groups underwent warm and cold additional retrograde flush (WS; warm solution group, CS; cold solution group). RESULTS: The fat removal rate in the antegrade flush was equal in both groups (3.0 ± 0.6% vs 3.0 ± 0.4%, p = 0.46); however, the rate was significantly greater in the WS group in retrograde flush (25.2 ± 3.2% vs 8.0 ± 1.4%, p = 0.01). Histology with Oil Red O staining and its software analysis showed more residual fat in the CS group (0.12 ± 0.01% vs 0.38 ± 0.07%, p = 0.01). There was no significant difference in the pulmonary function and hemodynamics during the 3-h period after reperfusion. CONCLUSION: Warm retrograde perfusion can remove more fat from lung grafts with fat embolism in a porcine donor model.

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  • Impact of chronic lung allograft dysfunction, especially restrictive allograft syndrome, on the survival after living-donor lobar lung transplantation compared with cadaveric lung transplantation in adults: a single-center experience. Reviewed

    Sugimoto S, Yamamoto H, Kurosaki T, Otani S, Okazaki M, Yamane M, Toyooka S, Oto T

    Surgery today   49 ( 8 )   686 - 693   2019.8

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    PURPOSE: The differences in chronic lung allograft dysfunction (CLAD) between living-donor lobar lung transplantation (LDLLT) and cadaveric lung transplantation (CLT) remain unclear. We conducted this study to compare the impact of CLAD on the outcomes after LDLLT vs. CLT. METHODS: We conducted a retrospective review of the data of 97 recipients of bilateral lung transplantation, including 51 recipients of LDLLT and 46 recipients of CLT. RESULTS: The CLAD-free survival and overall survival after LDLLT were similar to those after CLT. CLAD and restrictive allograft syndrome (RAS), but not bronchiolitis obliterans syndrome (BOS), developed significantly later after LDLLT than after CLT (p = 0.015 and p = 0.035). Consequently, patients with CLAD and RAS, but not those with BOS, after LDLLT had a significantly better overall survival than those after CLT (p = 0.037 and p = 0.0006). Furthermore, after the diagnosis of CLAD, the survival of patients with RAS after LDLLT tended to be better than that after CLT (p = 0.083). CONCLUSION: CLAD, especially RAS, appears to develop later after LDLLT than after CLT and seems to have a lower impact on the overall survival after LDLLT than that after CLT.

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  • Lung transplantation via cardiopulmonary bypass: excellent survival outcomes from extended criteria donors. Reviewed

    Taka H, Miyoshi K, Kurosaki T, Douguchi T, Itoh H, Sugimoto S, Yamane M, Kobayashi M, Kasahara S, Oto T

    General thoracic and cardiovascular surgery   67 ( 7 )   624 - 632   2019.7

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    ObjectivesThe role of intraoperative cardiopulmonary bypass (CPB) in lung transplant (LTx) surgery is controversial. CPB enables slow pulmonary reperfusion and initial ventilation with low oxygen concentrations, both theoretically protective of transplanted lungs. In this study, we explored clinical outcomes following extended criteria donor LTx surgery implementing a thoroughly protective allograft reperfusion strategy using CPB.MethodsThirty-nine consecutive adult patients who underwent bilateral LTx with elective CPB and protective allograft reperfusion were reviewed. Bilaterally implanted lungs were reperfused simultaneously, via slow CPB flow reduction and initial ventilation with 21% oxygen and nitric oxide, followed by a brief modified ultrafiltration. During weaning from CPB, mean pulmonary arterial pressure was strictly maintained at 10-15mmHg by controlling CPB and pulmonary flow. The clinical outcomes in 23 patients who received lungs from extended criteria donors (ECD group) were elucidated and compared to 16 patients undergoing LTx from standard criteria donors (SCD group).ResultsNo life-threatening deterioration was observed to graft functionality during the first 72h after LTx in the ECD group; however, only one patient required post-transplant extracorporeal membrane oxygenation. In three of 23 ECD LTx patients (12%), surgical revision for bleeding was required. Survival outcomes for the ECD group were favorable, with 100% survival at 6-months, 87.0% at 1-year, and 80.7% at 5-years. Outcomes in the ECD group were comparable to those in the SCD group.ConclusionsDespite a certain extent of risk associated with full-dose heparinization, use of CPB does not undermine survival outcomes after ECD LTx surgery if protective allograft reperfusion is securely performed.

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  • Prolonged warm ischemia exacerbated acute rejection after lung transplantation from donation after cardiac death in a mouse. Reviewed

    Hirano Y, Sugimoto S, Yamamoto S, Okada M, Otani S, Ohara T, Yamane M, Matsukawa A, Oto T, Toyooka S

    General thoracic and cardiovascular surgery   68 ( 1 )   57 - 62   2019.7

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    OBJECTIVE: In lung transplantation (LTx) from donation after cardiac death (DCD), the donor lungs are inevitably exposed to warm ischemic time (WIT) between the cardiac arrest and the initiation of cold preservation. We conducted this study to examine the effect of prolonged WIT on lung allograft rejection in a murine model of LTx from DCD. METHODS: Allogeneic BALB/c → B6 LTx from DCD was performed with a WIT of 15 min (WIT15 group, n = 5) or 60 min (WIT60 group, n = 5). Recipients were immunosuppressed by perioperative costimulatory blockade. The lung allografts were analyzed by histology and flow cytometry on day 7 after the LTx. RESULTS: Histologically, the rejection grade in the WIT60 group was significantly higher than that in the WIT15 group (3.4 ± 0.4 vs. 2.2 ± 0.2, P = 0.0278). Moreover, the intragraft CD8+ to CD4+ T cell ratio in the WIT60 group was significantly higher than that in the WIT15 group (2.3 ± 0.12 vs. 1.2 ± 0.11, P < 0.0001). CONCLUSIONS: Prolonged WIT could exacerbate the severity of lung allograft rejection after LTx from DCD. Minimization of the WIT could improve the outcomes after LTx from DCD.

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  • Cavernous hemangioma of the rib mimicking a chondrosarcoma: Diagnostic value of delayed phase MRI Reviewed

    T. Tanaka, Y. Masaoka, S. Sugimoto, T. Iguchi, T. Hiraki, H. Yanai, S. Kanazawa

    Diagnostic and Interventional Imaging   100 ( 7-8 )   455 - 457   2019.7

  • SOCS3 overexpression in T cells ameliorates chronic airway obstruction in a murine heterotopic tracheal transplantation model. Reviewed

    Mesaki K, Yamane M, Sugimoto S, Fujisawa M, Yoshimura T, Kurosaki T, Otani S, Miyoshi S, Oto T, Matsukawa A, Toyooka S

    Surgery today   49 ( 5 )   443 - 450   2019.5

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    PURPOSE: Suppressor of cytokine signaling-3 (SOCS3) is a negative feedback inhibitor of cytokine signaling with T-cell-mediated immunosuppressive effects on obliterative bronchiolitis (OB). In this study, we aimed to investigate the impact of T-cell-specific overexpression of SOCS3 using a murine heterotopic tracheal transplantation (HTT) model. METHODS: Tracheal allografts from BALB/c mice were subcutaneously transplanted into wild-type C57BL/6J (B6; WT) mice and SOCS3 transgenic B6 (SOCS3TG) mice. Tracheal allografts were analyzed by immunohistochemistry and quantitative polymerase chain reaction assays at days 7 and 21. RESULTS: At day 21, allografts in SOCS3TG mice showed significant amelioration of airway obstruction and epithelial loss compared with allografts in WT mice. The intragraft expression of IFN-γ and CXCL10 was suppressed, while that of IL-4 was enhanced in SOCS3TG mice at day 7. The T-bet levels were lower in SOCS3TG allografts than in WT allografts at day 7. CONCLUSION: We revealed that the overexpression of SOCS3 in T cells effectively ameliorates OB development in a murine HTT model by inhibiting the Th1 phenotype in the early phase. Our results suggest that the regulation of the T-cell response, through the modulation of SOCS expression, has potential as a new therapeutic strategy for chronic lung allograft dysfunction.

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  • Mitochondrial damage-associated molecular patterns released by lung transplants are associated with primary graft dysfunction. International journal

    Davide Scozzi, Mohsen Ibrahim, Fuyi Liao, Xue Lin, Hsi-Min Hsiao, Ramsey Hachem, Laneshia K Tague, Alberto Ricci, Hrishikesh S Kulkarni, Howard J Huang, Seiichiro Sugimoto, Alexander S Krupnick, Daniel Kreisel, Andrew E Gelman

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons   19 ( 5 )   1464 - 1477   2019.5

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    Primary graft dysfunction (PGD) is a major limitation in short- and long-term lung transplant survival. Recent work has shown that mitochondrial damage-associated molecular patterns (mtDAMPs) can promote solid organ injury, but whether they contribute to PGD severity remains unclear. We quantitated circulating plasma mitochondrial DNA (mtDNA) in 62 patients, before lung transplantation and shortly after arrival to the intensive care unit. Although all recipients released mtDNA, high levels were associated with severe PGD development. In a mouse orthotopic lung transplant model of PGD, we detected airway cell-free damaged mitochondria and mtDNA in the peripheral circulation. Pharmacologic inhibition or genetic deletion of formylated peptide receptor 1 (FPR1), a chemotaxis sensor for N-formylated peptides released by damaged mitochondria, inhibited graft injury. An analysis of intragraft neutrophil-trafficking patterns reveals that FPR1 enhances neutrophil transepithelial migration and retention within airways but does not control extravasation. Using donor lungs that express a mitochondria-targeted reporter protein, we also show that FPR1-mediated neutrophil trafficking is coupled with the engulfment of damaged mitochondria, which in turn triggers reactive oxygen species (ROS)-induced pulmonary edema. Therefore, our data demonstrate an association between mtDAMP release and PGD development and suggest that neutrophil trafficking and effector responses to damaged mitochondria are drivers of graft damage.

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  • Feasibility of lung transplantation from donors mechanically ventilated for prolonged periods. Reviewed

    Seiichiro Sugimoto, Takeshi Kurosaki, Shinji Otani, Shin Tanaka, Yukiko Hikasa, Masaomi Yamane, Shinichi Toyooka, Motomu Kobayashi, Takahiro Oto

    Surgery today   49 ( 3 )   254 - 260   2019.3

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    PURPOSE: When patients are mechanically ventilated for more than 5 days, they are usually declined as donors for lung transplantation (LTx); thus, the long-term outcomes of LTx from such donors remain unclear. We investigated the feasibility of LTx from donors that had been mechanically ventilated for prolonged periods. METHODS: The subjects of this retrospective comparative investigation were 31 recipients of LTx from donors who had been mechanically ventilated for < 5 days (short-term group) and 50 recipients of LTx from donors who had been mechanically ventilated for ≥ 5 days (long-term group). RESULTS: The median duration of donor mechanical ventilation was 3 days in the short-term group and 8.5 days in the long-term group. However, other than the difference in the duration of donor ventilation, there were no significant differences in the clinical characteristics of the donors or recipients between the groups. The overall survival rate after LTx was comparable between the long-term group and short-term group (5-year survival rate, 66.6% vs. 75.2%). CONCLUSION: The potential inclusion of donors who have been on mechanical ventilation for more than 5 days could be a feasible strategy to alleviate donor organ shortage.

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  • A single-nucleotide polymorphism in a gene modulating glucocorticoid sensitivity is associated with the decline in total lung capacity after lung transplantation. Reviewed

    Haruchika Yamamoto, Seiichiro Sugimoto, Shin Tanaka, Takeshi Kurosaki, Shinji Otani, Masaomi Yamane, Naruto Taira, Takahiro Oto, Shinichi Toyooka

    Surgery today   49 ( 3 )   268 - 274   2019.3

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    PURPOSE: Glucocorticoids are used to prevent chronic lung allograft dysfunction (CLAD) after lung transplantation (LT). Our study was aimed at assessing the association between the glucocorticoid-induced transcript 1 gene (GLCCI1) variant, which modulates glucocorticoid sensitivity, and the postoperative lung function and development of CLAD after LT. METHODS: A total of 71 recipients of LT were genotyped for the GLCCI1 variant (rs37972) and divided into three groups: the homozygous mutant allele (TT) group, the heterozygous mutant allele (CT) group, and the wild-type allele (CC) group. The results of pulmonary function tests were compared with the postoperative baseline values. RESULTS: The total lung capacity (TLC) in the TT group was significantly lower than that in the CC group at 3 years after LT (P = 0.029). In the recipients of cadaveric LT, the TLC and forced expiratory volume in 1 s in the TT group were significantly lower than those in the CC groups, resulting in a significant worse CLAD-free survival at 3 years after LT (P = 0.016). CONCLUSION: The GLCCI1 variant was associated with a significant decrease of the TLC at 3 years after LT and the development of CLAD at 3 years, especially in patients undergoing cadaveric LT.

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  • Lung transplant candidates with idiopathic pulmonary fibrosis and long-term pirfenidone therapy: Treatment feasibility influences waitlist survival. Reviewed International journal

    Tanaka S, Miyoshi K, Higo H, Kurosaki T, Otani S, Sugimoto S, Yamane M, Kiura K, Toyooka S, Oto T

    Respiratory investigation   57 ( 2 )   165 - 171   2019.3

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    BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronically progressive lung disease with exceptionally poor prognosis. While lung transplantation (LTx) is considered the last-resort therapeutic option, dismal waitlist mortality still hampers the salvage of patients with IPF. Pirfenidone, originally designed for IPF treatment, has increasingly been utilized. This study aimed to evaluate whether Pirfenidone could influence outcomes of patients with IPF on the Japanese LTx waitlist. METHODS: This retrospective single-center cohort study included 25 consecutive patients with IPF who were registered as LTx candidates at our institution between July 1999 and August 2016. Patients with a history of pretransplant Pirfenidone therapy (Pirfenidone group) were compared with those with no history (non-Pirfenidone group). RESULTS: In total, 6 (24%) patients received Pirfenidone as pretransplant therapy for 45.2 (range, 18.6-66.8) months. During the treatment period, the Pirfenidone group achieved a significant reduction in the decline rate of the forced vital capacity (-6.2% vs. -0.3%, p = 0.04) and a lower lung allocation score (31 vs. 41, p = 0.013) compared with the non-Pirfenidone group. The Pirfenidone group exhibited 100% waitlist survival three years after registration that was comparable to other indications, and 66% of the patients were still alive at the time of organ availability. No patient in the Pirfenidone group developed Pirfenidone-related surgical complications postoperatively. CONCLUSIONS: Patients with IPF successfully managed with long-term Pirfenidone therapy achieved favorable outcomes after LTx registration, comparable to other patients with LTx indications. The tolerability to antifibrotic therapy can be a predictor of waitlist survival.

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  • Long-term outcomes of pneumonectomy, back-table lung preservation, double-sleeve resection and reimplantation for advanced central lung cancer: the Oto procedure. Reviewed International journal

    Tanaka S, Sugimoto S, Soh J, Oto T

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery   56 ( 1 )   213 - 214   2018.12

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    The technique of pneumonectomy, back-table lung preservation, double-sleeve resection and reimplantation of basal segments (the Oto procedure) has been proposed as a useful technique for the management of locally advanced central lung cancer with short-term follow-up. We report the long-term outcomes of 5 consecutive patients who underwent the Oto procedure.

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  • SPRED2 deficiency may lead to lung ischemia-reperfusion injury via ERK1/2 signaling pathway activation. Reviewed

    Masanori Okada, Masaomi Yamane, Sumiharu Yamamoto, Shinji Otani, Kentaroh Miyoshi, Seiichiro Sugimoto, Akihiro Matsukawa, Shinichi Toyooka, Takahiro Oto, Shinichiro Miyoshi

    Surgery today   48 ( 12 )   1089 - 1095   2018.12

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    PURPOSE: Inflammatory changes during lung ischemia-reperfusion injury (IRI) are related to the activation of the extracellular signal-regulated kinase (ERK)1/2 signaling pathway. Sprouty-related EVH1 (enabled/vasodilator-stimulated phosphoprotein homology 1)-domain-containing proteins (SPREDs) are known inhibitors of ERK1/2 signaling. The role of SPRED2 in lung IRI was examined in a left hilar clamp mouse model. METHODS: C57BL/6 wild-type (WT) and Spred2-/- mice were used in the left hilar clamp model. Experimental groups underwent 30 min of left hilar clamping followed by 1 h of reperfusion. U0126, an ERK1/2 inhibitor, was administered to Spred2-/- mice with reperfused lungs. RESULTS: The partial pressures of oxygen of the Spred2-/- mice after reperfusion were significantly worse than those of WT mice (p < 0.01). Spred2-/- mice displayed more severe injuries than WT mice with increased neutrophil infiltration observed by a histological evaluation and flow cytometry (p < 0.001). This severe inflammation was inhibited by U0126. In addition, the rate of ERK1 activation was significantly higher in the lungs of Spred2-/- mice after reperfusion than in WT mice according to a Western blot analysis (p < 0.05). CONCLUSION: The activation of the ERK1/2 signaling pathway influences the severity of lung IRI, causing inflammation with neutrophil infiltration. SPRED2 may be a promising target for the suppression of lung IRI.

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  • Donor-derived cell-free DNA is associated with acute rejection and decreased oxygenation in primary graft dysfunction after living donor-lobar lung transplantation. Reviewed International journal

    Shin Tanaka, Seiichiro Sugimoto, Takeshi Kurosaki, Kentaroh Miyoshi, Shinji Otani, Ken Suzawa, Shinsuke Hashida, Masaomi Yamane, Takahiro Oto, Shinichi Toyooka

    Scientific reports   8 ( 1 )   15366 - 15366   2018.10

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    Donor-derived cell-free DNA (dd-cf-DNA) has been shown to be an informative biomarker of rejection after lung transplantation (LT) from deceased donors. However, in living-donor lobar LT, because small grafts from blood relatives are implanted with short ischemic times, the detection of dd-cf-DNA might be challenging. Our study was aimed at examining the role of dd-cf-DNA measurement in the diagnosis of primary graft dysfunction and acute rejection early after living-donor lobar LT. Immediately after LT, marked increase of the plasma dd-cf-DNA levels was noted, with the levels subsequently reaching a plateau with the resolution of primary graft dysfunction. Increased plasma levels of dd-cf-DNA were significantly correlated with decreased oxygenation immediately (p = 0.022) and at 72 hours (p = 0.046) after LT. Significantly higher plasma dd-cf-DNA levels were observed in patients with acute rejection (median, 12.0%) than in those with infection (median, 4.2%) (p = 0.028) or in a stable condition (median, 1.1%) (p = 0.001). Thus, measurement of the plasma levels of dd-cf-DNA might be useful to monitor the severity of primary graft dysfunction, and plasma dd-cf-DNA could be a potential biomarker for the diagnosis of acute rejection after LT.

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  • Low-risk donor lungs optimize the post-lung transplant outcome for high lung allocation score patients. Reviewed

    Takeshi Kurosaki, Kentaroh Miyoshi, Shinji Otani, Kentaro Imanishi, Seiichiro Sugimoto, Masaomi Yamane, Motomu Kobayashi, Shinichi Toyooka, Takahiro Oto

    Surgery today   48 ( 10 )   928 - 935   2018.10

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    PURPOSE: The lung allocation score (LAS) has been generally recognized as a contributor to the overall survival in lung transplant candidates. However, donor-related risks have never been taken into consideration in previous research that validated the LAS. This study aimed to determine whether or not the role of the LAS as a predictor of the posttransplant outcome is influenced by the quality of the donor lungs. METHODS: We retrospectively reviewed 108 patients who underwent lung transplantation at Okayama University Hospital since 1998. The cohort was divided into two groups based on the lung donor score (DS; ≤ 4/> 4). Correlations between the LAS and posttransplant outcomes were investigated in both groups. RESULTS: In the high-DS group, an elevated LAS was strongly associated with posttransplant PaO2/FiO2 (p = 0.018). However, in the low-DS group, no correlation was found between them. There was no significant difference in the long-term survival according to the LAS in the low-DS group. The LAS effectively predicted the posttransplant outcome only when lungs with DS > 4 were transplanted; the LAS was not reliable if high-quality lungs were transplanted. CONCLUSION: Lung transplantation can be feasible and provides a survival benefit even for high-LAS patients if lungs from a low-risk donor are transplanted.

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  • Can pretransplant computed-tomographic assessment predict outcomes after lung transplantation? International journal

    Seiichiro Sugimoto

    Journal of thoracic disease   10 ( 10 )   5652 - 5654   2018.10

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  • Myoepithelioma occurring in the posterior mediastinum harboring EWSR1 rearrangement: a case report. Reviewed International journal

    Tomohiro Habu, Junichi Soh, Tomohiro Toji, Kazuhiko Shien, Eito Niman, Kei Namba, Hiroki Sato, Hiromasa Yamamoto, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka

    Japanese journal of clinical oncology   48 ( 9 )   851 - 854   2018.9

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    Myoepithelioma is a rare neoplasm usually occurring in the salivary glands or the mammary glands but also, more rarely, in the thoracic cavity. The diagnosis of myoepithelioma is based on the presence of histological and immunohistochemical characteristics of myoepithelioma, but in unusual locations, the diagnosis is challenging. For such cases, cytogenetic approaches have been developed as helpful tools for the diagnosis. We report a surgical case of 51-year-old woman with myoepithelioma occurring in the posterior mediastinum that harbored the Ewing sarcoma breakpoint region1 (EWSR1) gene rearrangement. To the best of our knowledge, this is the first report of a myoepithelioma occurring in the posterior mediastinum. In this case, the patient underwent the thoracoscopic surgery for a diagnostic tumorectomy and was diagnosed as myoepithelioma based on the following immunohistological findings. Considering the unusual location, we additionally performed a cytogenetic analysis to confirm the presence of the EWSR1 gene rearrangement, which is a genetic characteristic of myoepithelioma.

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  • Airway complications have a greater impact on the outcomes of living-donor lobar lung transplantation recipients than cadaveric lung transplantation recipients. Reviewed

    Seiichiro Sugimoto, Masaomi Yamane, Shinji Otani, Takeshi Kurosaki, Shuji Okahara, Yukiko Hikasa, Shinichi Toyooka, Motomu Kobayashi, Takahiro Oto

    Surgery today   48 ( 9 )   848 - 855   2018.9

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    PURPOSE: Airway complications (ACs) after living-donor lobar lung transplantation (LDLLT) could have different features from those after cadaveric lung transplantation (CLT). We conducted this study to compare the characteristics of ACs after LDLLT vs. those after CLT and investigate their impact on outcomes. METHODS: We reviewed, retrospectively, data on 163 recipients of lung transplantation, including 83 recipients of LDLLT and 80 recipients of CLT. RESULTS: The incidence of ACs did not differ between LDLLT and CLT. The initial type of AC after LDLLT was limited to stenosis in all eight patients, whereas that after CLT consisted of stenosis in three patients and necrosis in ten patients (p = 0.0034). ACs after LDLLT necessitated significantly earlier initiation of treatment than those after CLT (p = 0.032). The overall survival rate of LDLLT recipients with an AC was significantly lower than that of those without an AC (p = 0.030), whereas the overall survival rate was comparable between CLT recipients with and those without ACs (p = 0.25). CONCLUSION: ACs after LDLLT, limited to bronchial stenosis, require significantly earlier treatment and have a greater adverse impact on survival than ACs after CLT.

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  • Unilateral lung transplantation using intact bilateral upper lobes. Reviewed International journal

    Shinji Otani, Takeshi Kurosaki, Seiichiro Sugimoto, Masaomi Yamane, Takahiro Oto

    The Journal of thoracic and cardiovascular surgery   156 ( 1 )   e35-e38 - e38   2018.7

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  • Favorable survival in lung transplant recipients on preoperative low-dose, as compared to high-dose corticosteroids, after hematopoietic stem cell transplantation. Reviewed

    Seiichiro Sugimoto, Kentaroh Miyoshi, Takeshi Kurosaki, Shinji Otani, Masaomi Yamane, Motomu Kobayashi, Takahiro Oto

    International journal of hematology   107 ( 6 )   696 - 702   2018.6

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    Although the number of patients developing pulmonary complications after hematopoietic stem cell transplantation (HSCT) necessitating lung transplantation (LT) is increasing, a little information is available about factors influencing the prognosis after LT in these patients. Corticosteroids represent the first-line therapy for pulmonary complications after HSCT; however, prolonged corticosteroid treatment prior to LT increases the potential risks of LT. In this study, we assessed the effect of preoperative corticosteroid therapy on long-term survival in patients undergoing LT after HSCT. We retrospectively investigated data from 13 patients who had received high-dose corticosteroid therapy and nine who had received low-dose corticosteroid therapy prior to LT for pulmonary complications after HSCT. Other than the preoperative corticosteroid dose, patient clinical characteristics did not differ. The incidence of postoperative complications within the first year after LT was significantly lower in the low-dose corticosteroid group (p = 0.026). Survival after LT was also significantly better in the low-dose corticosteroid group than in the high-dose corticosteroid group (p = 0.034). In recipients of LT after HSCT, preoperative low-dose corticosteroid use, as compared to preoperative high-dose corticosteroid use, could limit the risks of postoperative complications developing within the first year after the LT, leading to improved long-term survival after LT.

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  • Prognostic Factors in Lung Transplantation after Hematopoietic Stem Cell Transplantation Reviewed International journal

    Toyofumi F. Chen-Yoshikawa, Seiichiro Sugimoto, Takeshi Shiraishi, Masato Minami, Yasushi Matsuda, Masayuki Chida, Sumiko Maeda, Akihiro Aoyama, Yoshinori Okada, Meinoshin Okumura, Akinori Iwasaki, Shinichiro Miyoshi, Takahiro Oto, Hiroshi Date

    Transplantation   102 ( 1 )   154 - 161   2018.1

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    Background Lung transplantation is the final lifesaving option for patients with pulmonary complications after hematopoietic stem cell transplantation (HSCT). Patients undergoing HSCT for hematologic diseases are thought to be high-risk candidates for lung transplantation
    therefore, few lung transplants are performed for these patients, and few studies have been reported. This study aimed to describe the characteristics and outcomes of lung transplantation in patients with pulmonary complications after HSCT. Methods We retrospectively investigated 62 patients who underwent lung transplantation after HSCT. All data were collected from 6 lung transplant centers in Japan. Results Seventeen patients underwent cadaveric lung transplantation, whereas 45 underwent living-donor lobar lung transplantation (LDLLT). In the LDLLT group, 18 patients underwent LDLLT after HSCT in which one of the donors had also served as a donor for HSCT. Seven patients underwent single LDLLT for which the donor was the same as the patient from whom stem cells were obtained for HSCT. Preoperative hypercapnia was observed in 52 patients (84%). Thirteen patients (21%) required mechanical ventilation preoperatively. Fifty-five patients underwent HSCT for hematologic malignancies, and 4 (7%) relapsed after lung transplantation. The 5-year survival rate was 64.2%. In a multivariable analysis, patients younger than 45 years and those with the same donor for both procedures exhibited significantly better survival (P = 0.012 and 0.041, respectively). Conclusions Lung transplantation for pulmonary complications after HSCT was performed safely and yielded better survival, especially in younger recipients for whom both lung transplantation and HSCT involved the same donor.

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  • Pneumatosis intestinalis after lung transplantation for pulmonary graft-versus-host disease. Reviewed International journal

    Kumi Mesaki, Seiichiro Sugimoto, Shinji Otani, Takeshi Kurosaki, Kentaroh Miyoshi, Masaomi Yamane, Takahiro Oto

    Journal of thoracic disease   10 ( 1 )   E42-E45 - E45   2018.1

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    Pneumatosis intestinalis, which could complicate a spectrum of clinical conditions ranging from benign to life-threatening, is a rarely encountered complication after lung transplantation (LT). We describe two cases in which PI developed as a complication following LT for pulmonary graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation (HSCT). In addition to the long-term immunosuppression administered for pulmonary GVHD, the intense immunosuppression needed after LT might increase the risk of PI in lung transplant recipients after HSCT. Conservative therapy should be considered for the treatment of PI developing after LT.

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  • Postoperative pyoderma gangrenosum exacerbated by granulocyte-colony stimulating factor after lung cancer surgery Reviewed International journal

    Haruchika Yamamoto, Seiichiro Sugimoto, Shinji Otani, Shinichi Toyooka

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   47 ( 10 )   991 - 992   2017.10

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  • Lung retransplantation in an adult 13 years after single lobar transplant in childhood. Reviewed

    Seiichiro Sugimoto, Shinji Otani, Takashi Ohki, Takeshi Kurosaki, Kentaroh Miyoshi, Masaomi Yamane, Shinichiro Miyoshi, Takahiro Oto

    General thoracic and cardiovascular surgery   65 ( 9 )   539 - 541   2017.9

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    Single living-donor lobar lung transplantation provides acceptable results for critically ill children; however, an additional lung transplantation may be required in the future as the recipient grows. We describe a case of successful lung retransplantation in a grown-up patient after single lobar lung transplantation in childhood. A 23-year-old man underwent bilateral cadaveric lung retransplantation for chronic lung allograft dysfunction 13 years after right single living-donor lobar transplantation for idiopathic pulmonary arterial hypertension performed at the age of 10 years. The postoperative course was uneventful. The patient had received growth hormone therapy at a local hospital for 3 years until the development of chronic lung allograft dysfunction after the initial transplantation. Pediatric recipients undergoing single living-donor lobar lung transplantation should be cautiously followed for potential retransplantation.

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  • High Frequency of Acute Adverse Cardiovascular Events After Lung Transplantation in Patients With Pulmonary Arterial Hypertension Receiving Preoperative Long-Term Intravenous Prostacyclin. Reviewed

    Satoshi Akagi, Takahiro Oto, Motomu Kobayashi, Kentaroh Miyoshi, Seiichiro Sugimoto, Masaomi Yamane, Kazufumi Nakamura, Toshihiro Sarashina, Shinichiro Miyoshi, Hiroshi Ito

    International heart journal   58 ( 4 )   557 - 561   2017.8

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    Adverse cardiovascular events after lung transplantation (LT) increase the mortality in patients with pulmonary arterial hypertension (PAH). Long-term intravenous prostacyclin is the usual treatment in severe patients with PAH, but it may increase the risk of hemorrhage due to its antiplatelet aggregation effect or thrombocytopenia. We investigated the impact of length of intravenous prostacyclin therapy on acute adverse cardiovascular events including hemorrhagic complication after LT. We retrospectively compared the incidence of adverse events (death, intrathoracic hematoma and bleeding, cardiac congestion or shock, cerebral infarction and pulmonary embolism) within 30 days after LT between no/short-term (median 0.6 years, n = 13) and long-term (median 3.7 years, n = 15) intravenous prostacyclin groups. There were no differences in the dose of intravenous prostacyclin and pulmonary artery pressure between the two groups. Among 22 adverse events (0.8 ± 1.1 events/patient), 4 events occurred in the no/short-term intravenous prostacyclin group and 18 occurred in the long-term intravenous prostacyclin group. The event rate per patient in the long-term intravenous prostacyclin group (1.2 ± 1.3 events/patient) was significantly higher than that in the no/short-term intravenous prostacyclin group (0.3 ± 0.5 events/patient) (P < 0.05). Intrathoracic hematoma and bleeding was the most frequent adverse event (9 events, 41%). Preoperative long-term intravenous prostacyclin therapy increases acute adverse cardiovascular events after LT in patients with PAH.

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  • Successful Lung Transplantation Using a Deceased Donor Mechanically Ventilated for Ten Months Reviewed International journal

    Shin Tanaka, Kentaroh Miyoshi, Seiichiro Sugimoto, Masaomi Yamane, Motomu Kobayashi, Takahiro Oto

    ANNALS OF THORACIC SURGERY   104 ( 2 )   E177 - E179   2017.8

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    A successful outcome after lung transplant was achieved using lungs donated from a teenage boy who underwent prolonged mechanical ventilation. The donor experienced hypoxic brain damage and was declared brain dead 324 days after tracheal intubation. At the time of referral, the donor's lungs revealed diffuse radiologic infiltration and atelectasis but excellent function, with a PaO2/FiO(2) ratio of 450. The lungs were transplanted to a 10-year-old girl with bronchiolitis obliterans. She developed grade 2 primary graft dysfunction, but recovered quickly. She is doing well and has not experienced any other critical adverse events 12 months after lung transplantation. (C) 2017 by The Society of Thoracic Surgeons

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  • Prolonged Administration of Twice-Daily Bolus Intravenous Tacrolimus in the Early Phase After Lung Transplantation Reviewed International journal

    Yutaka Hirano, Seiichiro Sugimoto, Toshifumi Mano, Takeshi Kurosaki, Kentaroh Miyoshi, Shinji Otani, Masaomi Yamane, Motomu Kobayashi, Shinichiro Miyoshi, Takahiro Oto

    ANNALS OF TRANSPLANTATION   22   484 - 492   2017.8

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    Background: Although administration of tacrolimus, whether by the enteric, sublingual, or continuous intravenous routes, has some limitations, twice-daily bolus intravenous tacrolimus administration has been shown to be beneficial in optimizing efficacy and safety after lung transplantation. However, at present, the duration of bolus intravenous tacrolimus administration is limited, and the effects of prolonged bolus intravenous tacrolimus administration remain unknown. Our study was aimed at assessing the safety and efficacy of prolonged twice-daily bolus intravenous tacrolimus administration in the early phase after lung transplantation.
    Material/Methods: We retrospectively investigated the data of 62 recipients of lung transplantation who had received twice-daily bolus intravenous administration of tacrolimus, followed by oral tacrolimus, after lung transplantation at our institution between January 2011 and October 2015.
    Results: The median duration of bolus intravenous tacrolimus administration was 19 days (4-72 days). The target trough level was achieved in 89% of the patients by day 3. Acute kidney injury occurred in 27% of the patients during bolus intravenous tacrolimus. Two patients (3%) had neurotoxicity, necessitating discontinuation of tacrolimus. Suspected acute rejection requiring steroid pulse therapy occurred in 21% of patients during the followup period. Eight patients (13%) developed chronic lung allograft dysfunction during the follow-up period. The 1-year and 5-year survival rates after lung transplantation were 95% and 76%, respectively.
    Conclusions: These results suggest that prolonged bolus intravenous tacrolimus administration in the early phase after lung transplantation is a safe and effective alternative to enteric, sublingual, or continuous intravenous administration.

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  • Successful Lung Transplantation for Pulmonary Disease Associated With Erdheim-Chester Disease Reviewed International journal

    Kohei Hashimoto, Kentaroh Miyoshi, Hisao Mizutani, Shinji Otani, Seiichiro Sugimoto, Masaomi Yamane, Takahiro Oto

    ANNALS OF THORACIC SURGERY   104 ( 1 )   E13 - E15   2017.7

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    A 53-year-old man with pulmonary fibrosis associated with Erdheim-Chester disease achieved long-term survival after lung transplantation. Major clinical manifestations included lung and bone injuries, and other vital organs were functionally unaffected by the disease. After a careful observation for the disease progression, he underwent bilateral deceased-donor lung transplantation. He has returned to his normal social life and is doing well without recurrence of Erdheim-Chester disease in the lung allograft or progression in other organs 5 years after transplant. Lung transplantation is a potentially reasonable treatment option for Erdheim-Chester disease involving the lungs if the functions of other vital organs remain stable. (C) 2017 by The Society of Thoracic Surgeons

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  • Clinical characteristics of Japanese candidates for lung transplant for interstitial lung disease and risk factors for early death while on the waiting list. Reviewed International journal

    Hisao Higo, Takeshi Kurosaki, Eiki Ichihara, Toshio Kubo, Kentaroh Miyoshi, Shinji Otani, Seiichiro Sugimoto, Masaomi Yamane, Nobuaki Miyahara, Katsuyuki Kiura, Shinichiro Miyoshi, Takahiro Oto

    Respiratory investigation   55 ( 4 )   264 - 269   2017.7

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    BACKGROUND: Lung transplants have produced very favorable outcomes for patients with interstitial lung disease (ILD) in Japan. However, because of the severe donor lung shortage, patients must wait approximately 2.5 years before they can undergo transplantation and many candidates die before allocation. We reveal the clinical characteristics of Japanese patients with ILD who are candidates for lung transplants and the risk factors for early death while on the waiting list. METHODS: We retrospectively reviewed the clinical data of patients registered in the Japan Organ Transplant Network from Okayama University Hospital who are candidates for cadaveric lung transplants for ILD between 1999 and 2015. RESULTS: Fifty-three patients with ILD were included (24 patients with idiopathic pulmonary fibrosis and 29 others). They had severe pulmonary dysfunction and low exercise tolerability. The median waiting time for transplantation was 462 days, and 22 patients died before allocation. Patients who died before 462 days without undergoing transplantation had more severe dyspnea, shorter 6-minute walk distance (6MWD), and lower performance status than those who waited ≥462 days. CONCLUSIONS: Japanese candidates for cadaveric lung transplants for ILD have severe pulmonary dysfunction. Severe dyspnea, short 6MWD, and low performance status are risk factors for early death while on the waiting list.

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  • Early postoperative complications after middle lobe-preserving surgery for secondary lung cancer Reviewed

    Yuho Maki, Shinichi Toyooka, Junichi Soh, Hiromasa Yamamoto, Seiichiro Sugimoto, Masaomi Yamane, Takahiro Oto, Shinichiro Miyoshi

    SURGERY TODAY   47 ( 5 )   601 - 605   2017.5

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    Purpose Preservation of the middle lobe during lung surgery is traditionally avoided, because its presence in the hemithoracic cavity is considered a cause of complications. We report a series of lung cancer patients who underwent a secondary pulmonary resection with the preservation of the middle lobe to explore the complications and feasibility of these procedures.
    Methods We reviewed the clinical courses of six patients who underwent surgery for metachronous lung cancers. Five patients underwent right upper lobectomy, including one sleeve lobectomy, after having undergone prior right lower lobectomy. The remaining patient underwent a right lower lobectomy after having undergone a prior right upper lobectomy.
    Results There were no treatment-related deaths. One patient was readmitted for surgery to treat delayed air leakage progressing to pyothorax. One patient was treated for persistent air leakage. Two patients required intermittent drainage of pulmonary effusion, because of middle lobe atelectasis. The postoperative forced vital capacity and forced expiratory volume in 1 s were greater than the values predicted post-pneumonectomy in four evaluable patients.
    Conclusions While postoperative complications after middle lobe-preserving surgery are manageable, their high incidence should be considered when performing this surgery.

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  • Pulmonary artery patch for an inadequate donor atrial cuff in the absence of donor pericardium in lung transplantation Reviewed

    Seiichiro Sugimoto, Masaomi Yamane, Kentaroh Miyoshi, Takeshi Kurosaki, Shinji Otani, Shinichiro Miyoshi, Takahiro Oto

    SURGERY TODAY   47 ( 3 )   399 - 401   2017.3

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    In cadaveric lung transplantation (LTx), a donor lung with an inadequate donor left atrial cuff is considered a "surgically marginal donor lung". The donor pericardium is commonly applied to reconstruct the inadequate donor left atrial cuff; however, in some cases, the donor pericardium is inadvertently removed during the lung procurement. We devised an alternative technique for reconstruction to overcome the absence of pericardium in a donor lung with an inadequate atrial cuff, using a patch of the donor pulmonary artery (PA) in single lung transplantation. In a recent case of lung transplantation in which the donor pericardium had been removed, we harvested a segment of the right PA distal to the main PA of the donor and used a PA patch to repair the inadequate donor left atrial cuff. No vascular complications were encountered in the recipient, who remains in good health after the transplantation.

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  • Immunoglobulin G4-related disease presenting as an intrapericardial tumor Reviewed International journal

    Masanori Okada, Seiichiro Sugimoto, Masaomi Yamane, Shinichiro Miyoshi

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   47 ( 1 )   88 - 89   2017.1

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  • Reconstruction of Anterior Chest Wall with Polypropylene Mesh: Two Primary Sternal Chondrosarcoma Cases Reviewed

    Shinichi Kawana, Hiromasa Yamamoto, Yuho Maki, Seiichiro Sugimoto, Shinichi Toyooka, Shinichiro Miyoshi

    ACTA MEDICA OKAYAMA   71 ( 3 )   259 - 262   2017

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    Primary sternal chondrosarcoma is a rare malignant tumor that is refractory to chemotherapy and radiation. Effective therapy is radical resection of the tumor. We present two patients with primary sternal chondrosarcoma who underwent a radical resection of the lower half of the sternum and bilateral ribs, followed by reconstruction with 2 sheets of polypropylene mesh layered orthogonally. The patients have maintained almost the same pulmonary function as preoperative values, with stability of the chest wall. Although there are various ways to reconstruct the anterior chest wall, reconstruction with polypropylene mesh layered orthogonally is an easy-to-use and sufficient method.

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  • Visualization of bronchial circulation at bronchial anastomotic site using bronchial fluorescein angiography technique Reviewed International journal

    Norichika Iga, Kentaroh Miyoshi, Katsuyoshi Takata, Yutaka Hirano, Yusuke Konishi, Shinji Otani, Seiichiro Sugimoto, Masaomi Yamane, Shinichiro Miyoshi, Takahiro Oto

    INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY   23 ( 5 )   716 - 721   2016.11

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    Successful bronchial healing after a bronchoplastic procedure mainly depends on bronchial circulation at the anastomostic site. We developed a bronchial fluorescein angiography (B-FAG) technique for visualizing circulation on the bronchial surface. The technique was evaluated in animals.
    Fluorescein was used as a contrast agent and an autofluorescence imaging (AFI) bronchoscope as a detector. The left main pulmonary artery (PA) and main bronchus of 10 pigs were isolated. After transection of the left main bronchus and bronchial arteries and re-anastomosis of the bronchus, the pigs were randomly divided into two groups: the PA- group (n = 5), in which the pulmonary artery was transected; and the PA+ group (n = 5), in which the pulmonary artery was preserved. Following intravenous injection of fluorescein, the distal anastomotic site was observed for 30 min with autofluorescence imaging bronchoscopy. Bronchial specimens sampled 2 days after the surgical intervention were histologically evaluated.
    In the PA- group, there was no fluorescein enhancement in the distal bronchus throughout the observation time. However, enhancement, which turned the bronchial surface from magenta to bright green, was clearly observed in less than 207 +/- 102.5 s in the PA+ group. The enhancement status detected by bronchial fluorescein angiography was related to the extent of tissue damage, as was proven histologically in the acute healing stage.
    Bronchial fluorescein angiography clearly visualized the circulatory status promptly after the anastomosis procedure at the central bronchus. This technique is a potentially practical approach to predict ischaemic airway complications following bronchial anastomosis.

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  • Balloon-expandable Metallic Stents for Airway Diseases Reviewed

    Takashi Ohki, Seiichiro Sugimoto, Takeshi Kurosaki, Shinji Otani, Kentaroh Miyoshi, Masaomi Yamane, Shinichiro Miyoshi, Takahiro Oto

    ACTA MEDICA OKAYAMA   70 ( 5 )   421 - 424   2016.10

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    Stent placement is an essential treatment for airway diseases. Although self-expandable metallic stents and silicone stents are commonly applied for the treatment of airway diseases, these stents are unsuitable for the treatment of small airway diseases encountered in pediatric patients and lung transplant recipients with airway complications. Currently, only vascular balloon-expandable metallic stents are available for the treatment of small airway diseases; however, little research has been conducted on the use of these stents in this field. We have launched a prospective feasibility study to clarify the safety and efficacy of balloon-expandable metallic stents for the treatment of airway diseases.

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  • The Feasibility of Median Sternotomy With or Without Thoracotomy for Locally Advanced Non-Small Cell Lung Cancer Treated With Induction Chemoradiotherapy Reviewed International journal

    Hiroki Sato, Shinichi Toyooka, Junichi Soh, Katsuyuki Hotta, Kuniaki Katsui, Hiromasa Yamamoto, Seiichiro Sugimoto, Takahiro Oto, Susumu Kanazawa, Katsuyuki Kiura, Shinichiro Miyoshi

    ANNALS OF THORACIC SURGERY   102 ( 3 )   985 - 992   2016.9

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    Background. This study aimed to compare the morbidity and mortality of a median sternotomy approach and a lateral thoracotomy and to investigate the feasibility of a median sternotomy for locally advanced non-small cell lung cancer (NSCLC) after induction chemoradiotherapy.
    Methods. The medical records of patients with locally advanced NSCLC who underwent induction chemoradiotherapy followed by surgery at our institution between January 1999 and September 2014 were reviewed. We compared the morbidity and mortality of a median sternotomy approach and a lateral thoracotomy.
    Results. A total of 102 NSCLC patients were the subjects of this study. Among them, 31 patients underwent surgery with a median sternotomy approach and 71 patients underwent surgery with a lateral thoracotomy. Patients in the median sternotomy group had a significantly higher rate of postoperative arrhythmia than those in the lateral thoracotomy group (p = 0.0028). However, all the complications were manageable, and no treatment-related deaths occurred in the median sternotomy group. Regarding the prognosis, the 5-year overall survival rate was 72.7%, and the 2-year recurrence-free survival rate was 66.5% in the entire population. No significant differences in overall survival or recurrence-free survival were observed between the 2 approaches.
    Conclusions. Whereas the lateral thoracotomy approach is a standard procedure, our experience suggests that a median sternotomy approach for locally advanced NSCLC after induction chemoradiotherapy is a feasible procedure and can be a surgical option. (C) 2016 by The Society of Thoracic Surgeons

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  • Lung transplantation for diffuse panbronchiolitis: 5 cases from a single centre Reviewed International journal

    Seiichiro Sugimoto, Kentaroh Miyoshi, Masaomi Yamane, Takahiro Oto

    INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY   22 ( 5 )   679 - 681   2016.5

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    Diffuse panbronchiolitis is a rare complex genetic disease predominantly affecting East Asians, and is characterized by chronic inflammation of the respiratory bronchioles and sinobronchial infection. Although long-term macrolide therapy has been shown to significantly improve the survival in patients with diffuse panbronchiolitis, some patients continue to deteriorate, eventually requiring lung transplantation. However, lung transplantation for diffuse panbronchiolitis has rarely been reported and the outcome in these patients remains unknown. We describe our experience of lung transplantation for diffuse panbronchiolitis. A total of 5 patients received long-term macrolide therapy and had airway colonization by Pseudomonas aeruginosa preoperatively. Three patients had undergone sinus surgery for chronic rhinosinusitis before the transplantation. Bilateral cadaveric lung transplantation was performed in 4 patients, and living-donor lung transplantation in 1. After the lung transplantation, 1 patient developed an A3 acute rejection episode; however, none of the recipients developed severe pneumonia or any fatal infections. One recipient developed chronic lung allograft dysfunction 3 years after the transplantation; however, none developed recurrence of diffuse panbronchiolitis. All of the 5 patients were still surviving after a median follow-up period of 4.9 years (3.7-12.3 years). Lung transplantation is a viable option for the treatment of progressive diffuse panbronchiolitis resistant to long-term macrolide therapy.

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  • Therapeutic Effect of Sirolimus for Lymphangioleiomyomatosis Remaining in the Abdominopelvic Region After Lung Transplantation: A Case Report. Reviewed

    Ito T, Suno M, Sakamoto K, Yoshizaki Y, Yamamoto K, Nakanishi R, Hirano Y, Irie M, Kurosaki T, Otani S, Yamane M, Sugimoto S, Miyoshi K, Oto T

    Transplantation proceedings   48 ( 1 )   271 - 274   2016.1

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  • [Cross-sectoral Approach of a Perioperative Management Center for General Thoracic Surgery]. Reviewed

    Atsushi Shimoda, Junichi Soh, Takako Ashiba, Naomichi Murata, Tomomi Fukuda, Motomu Kobayashi, Hidejiro Torigoe, Yuho Maki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka, Takahiro Oto, Shinichiro Miyoshi

    Kyobu geka. The Japanese journal of thoracic surgery   69 ( 1 )   20 - 4   2016.1

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    Perioperative assessment and care, such as enhanced recovery after surgery (ERAS), is very important for improving the clinical outcomes of patients who have undergone surgery. However, professional assessments and care cannot be achieved through the actions of only 1 surgical department. We established a perioperative management center(PERIO) comprised of surgeons, dedicated nurses, anesthesiologists, dentists, physiotherapists, pharmacists, and nutritionists to perform intensive cross-sectoral perioperative management. In this manuscript, we investigated the impact of PERIO on the clinical outcomes of 127 elderly patients who underwent thoracic surgery for the resection of non-small cell lung cancer (NSCLC). We categorized these 127 patients into 3 groups:① those treated before the introduction of PERIO (between January 2006 to August 2008), ② those treated during the early phase after PERIO introduction (September 2008 to December 2011), and ③ those treated during the late phase after PERIO introduction( January 2012 to December 2014). Radical operations were performed significantly more frequently after PERIO introduction than before PERIO introduction, while the postoperative complication rates were similar among the 3 groups. The duration of postoperative hospitalization was reduced after the introduction of PERIO, and the hospital surplus increased after the introduction of PERIO. In conclusion, PERIO may play an important role in improving the clinical outcomes of thoracic surgery, especially for elderly patients with NSCLC.

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  • A neutrophil elastase inhibitor improves lung function during ex vivo lung perfusion. Reviewed

    Masaaki Harada, Takahiro Oto, Shinji Otani, Kentaroh Miyoshi, Masanori Okada, Norichika Iga, Hitoshi Nishikawa, Seiichiro Sugimoto, Masaomi Yamane, Shinichiro Miyoshi

    General thoracic and cardiovascular surgery   63 ( 12 )   645 - 51   2015.12

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    OBJECTIVE: Ex vivo lung perfusion (EVLP) has been used not only for graft evaluation but also for graft reconditioning prior to lung transplantation. Inflammatory cells such as neutrophils may cause additional graft injury during EVLP. Neutrophil elastase inhibitors protect lungs against neutrophil-induced lung injury, such as acute respiratory distress syndrome. This study aimed to investigate the effect of a neutrophil elastase inhibitor during EVLP. METHODS: EVLP was performed for 4 h in bilateral pig lungs that had previously experienced warm ischemia for 2 h with or without a neutrophil elastase inhibitor (treated and control groups, respectively; n = 6). Following EVLP, the left lung was transplanted into a recipient pig, and this was followed by observation for 4 h. Pulmonary functions were observed both during EVLP and during the early post-transplant stage. RESULTS: During EVLP, decreases in neutrophil elastase levels (P < 0.001), the wet-dry weight ratio (P < 0.05), and pulmonary vascular resistance (P < 0.01) and increases in the PaO2/FiO2 ratio (P < 0.01) and pulmonary compliance (P < 0.05) were observed in the treated group. After transplantation, decreased pulmonary vascular resistance (P < 0.05) was observed in the treated group. CONCLUSIONS: A neutrophil elastase inhibitor attenuated the inflammatory response during EVLP and may decrease the incidence of lung reperfusion injury after transplantation.

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  • False-positive axillary lymph node on positron emission tomography/computed tomography in a thymoma patient with a tattoo Reviewed International journal

    Yuma Fukumoto, Seiichiro Sugimoto, Masanori Okada, Shinichiro Miyoshi

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   48 ( 5 )   804 - 804   2015.11

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  • Retained Short Hook Wires Used for Preoperative Localization of Small Pulmonary Lesions During Video-Assisted Thoracoscopic Surgery: A Report of 2 Cases Reviewed International journal

    Toshihiro Iguchi, Takao Hiraki, Hideo Gobara, Hiroyasu Fujiwara, Seiichiro Sugimoto, Shinichiro Miyoshi, Susumu Kanazawa

    CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY   38 ( 5 )   1376 - 1379   2015.10

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  • Extended sleeve lobectomy after induction chemoradiotherapy for non-small cell lung cancer Reviewed

    Shinichi Toyooka, Junichi Soh, Hiromasa Yamamoto, Masaomi Yamane, Shigeru Hattori, Kazuhiko Shien, Kentaroh Miyoshi, Seiichiro Sugimoto, Takahiro Oto, Shinichiro Miyoshi

    SURGERY TODAY   45 ( 9 )   1121 - 1126   2015.9

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    Extended sleeve lobectomy is a challenging surgery. While induction chemoradiotherapy (ChRT) followed by surgery is one of the therapeutic strategies used for locally advanced non-small cell lung cancer (NSCLC), ChRT can impair the anastomotic healing potential. We herein present our experience with cases who underwent an extended sleeve lobectomy after induction ChRT.
    The medical records of patients who underwent a surgery for NSCLC after ChRT were reviewed.
    Between December 2007 and January 2013, nine patients underwent an extended sleeve lobectomy; the left lingular division and lower lobe in four patients, the right upper lobe and trachea in one patient, the carina and trachea in one patient, the right middle and lower lobes in one patient, the right upper and middle lobes and carina in one patient and the right upper lobe and superior segment of the lower lobe in one patient. While no postoperative 90-day deaths occurred, one case developed a bronchopleural fistula on postoperative day (POD) 25 and one case developed a bronchovascular fistula on POD 163. No cases of local recurrence developed.
    Our experience suggests that an extended sleeve lobectomy after induction ChRT is feasible, but careful patient selection and perioperative management are mandatory.

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  • Primary pulmonary melanoma: a report of two cases Reviewed International journal

    Mototsugu Watanabe, Hiromasa Yamamoto, Shinsuke Hashida, Junichi Soh, Seiichiro Sugimoto, Shinichi Toyooka, Shinichiro Miyoshi

    WORLD JOURNAL OF SURGICAL ONCOLOGY   13   274 - 274   2015.9

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    Malignant melanoma is a refractory malignancy with a dismal prognosis. It generally arises from the skin in most cases, and cases of primary pulmonary malignant melanoma are rare and often behave aggressively. We have treated two cases of localized primary pulmonary malignant melanoma using surgical resection. Pulmonary malignant melanomas often metastasize to the brain and liver; one of our cases exhibited metastasis to the cecum at about 8 months after surgery. Because cutaneous melanomas often carry activating mutations in the BRAF gene (V600E), we performed a BRAF mutational analysis using direct sequencing for both of these tumors arising from the lung. However, no BRAF mutations were detected. We detected a p53 mutation, which was thought to be a potential somatic mutation, in one of the two cases using a sequencing panel targeting 20 lung cancer-related genes. Although we also checked the expression of programmed death ligand 1 (PD-L1) on the surface of the tumor cells by immunohistochemical testing, neither of our two cases expressed PD-L1. Further molecular analyses may uncover the characteristics of primary pulmonary malignant melanomas.

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  • Simultaneous Multiple Preoperative Localizations of Small Pulmonary Lesions Using a Short Hook Wire and Suture System Reviewed International journal

    Toshihiro Iguchi, Takao Hiraki, Hideo Gobara, Hiroyasu Fujiwara, Yusuke Matsui, Seiichiro Sugimoto, Shinichi Toyooka, Takahiro Oto, Shinichiro Miyoshi, Susumu Kanazawa

    CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY   38 ( 4 )   971 - 976   2015.8

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    The aim of the study was to retrospectively evaluate simultaneous multiple hook wire placement outcomes before video-assisted thoracoscopic surgery (VATS).
    Thirty-eight procedures were performed on 35 patients (13 men and 22 women; mean age, 59.9 years) with 80 lung lesions (mean diameter 7.9 mm) who underwent simultaneous multiple hook wire placements for preoperative localizations. The primary endpoints were technical success, complications, procedure duration, and VATS outcome; secondary endpoints included comparisons between technical success rates, complication rates, and procedure durations of the 238 single-placement procedures performed. Complications were also evaluated.
    In 35 procedures including 74 lesions, multiple hook wire placements were technically successful; in the remaining three procedures, the second target placement was aborted because of massive pneumothorax after the first placement. Although complications occurred in 34 procedures, no grade 3 or above adverse event was observed. The mean procedure duration was 36.4 +/- A 11.8 min. Three hook wires dislodged during patient transport to the surgical suite. Seventy-four successfully marked lesions were resected. Six lesions without hook wires were successfully resected after detection by palpation with an additional mini-thoracotomy or using subtle pleural changes as a guide. The complication rates and procedure durations of multiple-placement procedures were significantly higher (P = 0.04) and longer (P &lt; 0.001) than those in the single-placement group, respectively, while the technical success rate was not significantly different (P = 0.051).
    Simultaneous multiple hook wire placements before VATS were clinically feasible, but increased the complication rate and lengthened the procedure time.

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  • 肺移植後の気管支合併症に対する治療方針

    杉本誠一郎, 大藤剛宏

    今日の移植   28 ( 3 )   257 - 265   2015.6

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  • Kissing-stents technique after living-donor lobar lung transplantation Reviewed International journal

    Seiichiro Sugimoto, Takahiro Oto, Shinichi Toyooka, Shinichiro Miyoshi

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   47 ( 6 )   1105 - 1106   2015.6

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    Stent placement has become common practice for bronchial stenosis (BS) after lung transplantation (LT). Especially, segmental BS after lobar LT requires a complex stenting technique. We describe a case of multiple segmental bronchial stenoses treated by the kissing-stents technique using balloon-expandable metallic stents after living-donor lobar LT. Based on the vascular kissing-stents technique, we simultaneously placed two stents, side by side, in the superior segmental bronchus and the basal segmental bronchus of the right transplanted lobar lung. This technique may represent a valuable option for complex segmental BS after lobar LT.

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  • Use of Extended-Criteria Lungs on a Lobe-by-Lobe Basis Through Ex Vivo Lung Perfusion Assessment Reviewed International journal

    Kentaroh Miyoshi, Takahiro Oto, Yusuke Konishi, Yutaka Hirano, Masanori Okada, Norichika Iga, Shin Hirayama, Seiichiro Sugimoto, Masaomi Yamane, Motomu Kobayashi, Shinichiro Miyoshi

    ANNALS OF THORACIC SURGERY   99 ( 5 )   1819 - 1821   2015.5

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    Initially rejected and extended-criteria lungs were partially used through an ex vivo lung perfusion (EVLP) assessment that was first clinically applied in Asia. The truly injured lobe (left lower lobe) was identified during 89-minute normothermic EVLP and was excised, and the remaining lobes were successfully transplanted into a patient with lymphangioleiomyomatosis. The lung lobes showed heterogeneous changes on the ex vivo rig, and a brief duration of EVLP helped differentiate lung quality on a lobe-by-lobe basis. (C) 2015 by The Society of Thoracic Surgeons

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  • 呼吸器疾患 1 肺移植 適応とその実際,ホスピタリストが遭遇し得る合併症

    杉本誠一郎, 大藤剛宏

    Hospitalist   3 ( 1 )   220 - 225   2015.3

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    Takahiro Oto, Kentaroh Miyoshi, Seiichiro Sugimoto, Masaomi Yamane

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY   149 ( 3 )   E42 - E44   2015.3

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  • Pneumocephalus and Chylothorax Complicating Vertebrectomy for Lung Cancer Reviewed International journal

    Seiichiro Sugimoto, Masato Tanaka, Ken Suzawa, Hitoshi Nishikawa, Shinichi Toyooka, Takahiro Oto, Toshifumi Ozaki, Shinichiro Miyoshi

    ANNALS OF THORACIC SURGERY   99 ( 4 )   1425 - 1428   2015.3

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    Pneumocephalus is a rare, but potentially fatal complication of thoracic surgery. We describe a case of successful management of pneumocephalus complicated by persistent chylothorax developing after en bloc partial vertebrectomy performed after induction chemoradiotherapy for lung cancer invading the spine. Surgical treatment should be considered for pneumocephalus complicated by any condition requiring persistent chest drainage. (C) 2015 by The Society of Thoracic Surgeons

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  • Transfissural Route Used for Preoperative Localization of Small Pulmonary Lesions with a Short Hook Wire and Suture System Reviewed International journal

    Toshihiro Iguchi, Takao Hiraki, Hideo Gobara, Hiroyasu Fujiwara, Yusuke Matsui, Seiichiro Sugimoto, Shinichi Toyooka, Takahiro Oto, Shinichiro Miyoshi, Susumu Kanazawa

    CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY   38 ( 1 )   222 - 226   2015.2

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    We retrospectively evaluated the results of the transfissural route for preoperative localization with a short hook wire and suture system for video-assisted thoracoscopic surgery (VATS).
    Eleven patients with 11 tumors underwent CT-guided transfissural placement of a hook wire before VATS. This route was selected for all patients, because the distance between the tumor and interlobar fissure was much shorter than the required distance traversed using the conventional approach. Complications were evaluated using the National Cancer Institute Common Terminology Criteria for Adverse Events Version 4.0.
    The hook wire was successfully placed using the transfissural route in all but one case. Of these ten successful placements, two tumors needed a second puncture for optimal placement, because the CT scan showed that the first hook wire was not properly placed in the lung. In one patient, we did not attempt replacement after the first placement was incorrect. In ten successful procedures, the mean distance traversed in the parenchyma of the unaffected lung lobe was 27.9 mm. The distance between the pleura and placed hook wire was significantly shorter than the estimated distance between the pleura and hook wire using the conventional route (mean 16.3 vs. 40.9 mm; P = 0.0002). Grade 1 adverse events occurred (11 pneumothoraxes and 4 pulmonary hemorrhages). No grade 2 or higher adverse event was observed.
    The transfissural route used for preoperative localization before VATS is useful for selected patients because this route may allow for more limited lung parenchyma resection.

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  • 肺移植周術期におけるECMO

    杉本誠一郎, 三好健太郎, 大藤剛宏

    救急・集中治療   26 ( 11-12 )   1568 - 1572   2014.12

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  • Validity of using lobe-specific regional lymph node stations to assist navigation during lymph node dissection in early stage non-small cell lung cancer patients Reviewed

    Shinichiro Miyoshi, Kazuhiko Shien, Shinichi Toyooka, Kentaroh Miyoshi, Hiromasa Yamamoto, Seiichiro Sugimoto, Junichi Soh, Makio Hayama, Masaomi Yamane, Takahiro Oto

    SURGERY TODAY   44 ( 11 )   2028 - 2036   2014.11

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    Purpose The validity of our proposed lobe-specific regional lymph node stations (LSRLNS) was evaluated as a method for navigation during lymphadenectomy in patients with early stage non-small cell lung cancer (NSCLC).
    Methods A total of 725 NSCLC patients with c-T2N1M0 or less extensive disease who had undergone a curative operation with complete mediastinal lymph node dissection (MLND) were studied. The LSRLNS were #2, #3, #4 and #10 for the right upper lobe, #11i, #11s, #7 and #8 for the right lower lobe, #4, #5 and #6 for the left superior division, #11, #5 and #7 for the left lingular division and #11, #7 and #8 for the left lower lobe.
    Results If the LSRLNS were used for pathological examinations during surgery, 599 p-N0 and 39 p-N1 patients diagnosed with no metastasis would have been subjected to a selective MLND, while 20 p-N1 and 65 p-N2 patients who had a diagnosis of metastasis would have been navigated to a complete MLND. Two p-N2 patients with a diagnosis of no metastasis would have inappropriately undergone a selective MLND, resulting in the false negative rate at 0.3 %.
    Conclusion Intra-operative pathological examination using our LSRLNS may accurately reveal the status of metastasis, and appropriately lead to a selective or complete MLND in patients with c-T2N1M0 or less extensive disease.

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  • [Open-chest management with Esmarch bandages after lung transplantation]. Reviewed

    Eito Niman, Takahiro Oto, Shinji Otani, Seiichiro Sugimoto, Masaomi Yamane, Junichi Soh, Shinichiro Miyoshi

    Kyobu geka. The Japanese journal of thoracic surgery   67 ( 10 )   884 - 7   2014.9

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    There are patients in whom management in an open-chest state after lung transplantation is necessary due to over-sized grafts, heart failure, use of extracorporeal membrane oxygenation (ECMO), or bleeding. In such patients, we suture Esmarch bandages, which are used for orthopedic surgery, to the open chest wound and perform wound management. We report 3 patients in whom wound management using this method was performed due to postoperative cardiac failure, primary graft dysfunction, and a postoperative pulmonary edema, respectively. Due to improvement in the wound management method and use of appropriate antibiotics, each patient could be managed without developing wound infection. This method was also useful for the management of bleeding.

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  • Hyaluronan contributes to bronchiolitis obliterans syndrome and stimulates lung allograft rejection through activation of innate immunity. International journal

    Jamie L Todd, Xingan Wang, Seichiro Sugimoto, Vanessa E Kennedy, Helen L Zhang, Elizabeth N Pavlisko, Fran L Kelly, Howard Huang, Daniel Kreisel, Scott M Palmer, Andrew E Gelman

    American journal of respiratory and critical care medicine   189 ( 5 )   556 - 66   2014.3

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    RATIONALE: Although innate immunity is increasingly recognized to contribute to lung allograft rejection, the significance of endogenous innate ligands, such as hyaluronan (HA) fragments, in clinical or experimental lung transplantation is uncertain. OBJECTIVES: To determine if HA is associated with clinical bronchiolitis obliterans syndrome (BOS) in lung transplant recipients, and evaluate the effect of low- or high-molecular-weight HA on experimental lung allograft rejection, including dependence on innate signaling pathways or effector cells. METHODS: HA concentrations were measured in bronchoalveolar lavage and plasma samples from lung recipients with or without established BOS. BOS and normal lung tissues were assessed for HA localization and expression of HA synthases. Murine orthotopic lung recipients with established tolerance were treated with low- or high-molecular-weight HA under varied experimental conditions, including Toll-like receptor (TLR) 2/4 and myeloid differentiation protein 88 deficiency and neutrophil depletion. MEASUREMENTS AND MAIN RESULTS: HA localized within areas of intraluminal small airways fibrosis in BOS lung tissue. Moreover, transcripts for HA synthase enzymes were significantly elevated in BOS versus normal lung tissues and both lavage fluid and plasma HA concentrations were increased in recipients with BOS. Treatment with low-molecular-weight HA abrogated tolerance in murine orthotopic lung recipients in a TLR2/4- and myeloid differentiation protein 88-dependent fashion and drove expansion of alloantigen-specific T lymphocytes. Additionally, TLR-dependent signals stimulated neutrophilia that promoted rejection. In contrast, high-molecular-weight HA attenuated basal allograft inflammation. CONCLUSIONS: These data suggest that accumulation of HA could contribute to BOS by directly activating innate immune signaling pathways that promote allograft rejection and neutrophilia.

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  • Use of a vessel sealing system versus conventional electrocautery for lung parenchymal resection: a comparison of the clinicopathological outcomes in porcine lungs Reviewed

    Seiichiro Sugimoto, Shinichi Toyooka, Norichika Iga, Masashi Furukawa, Ryujiro Sugimoto, Kazuhiko Shien, Hitoshi Nishikawa, Junichi Soh, Masaomi Yamane, Takahiro Oto, Shinichiro Miyoshi

    SURGERY TODAY   44 ( 3 )   540 - 545   2014.3

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    LigaSure, a vessel sealing system, has been shown to have excellent hemostatic properties; however, its use for lung parenchymal resection has been limited. We herein examined the hemostatic properties and potential for inducing histological lung injury of the LigaSure system in non-anatomic pulmonary resection to estimate the feasibility of its clinical application.
    Non-anatomic pulmonary wedge resections of the right cranial, middle, and caudal lobes were performed in four pigs using the LigaSure system (Group A) or electrocautery (Group B). In each resection, the resection time, blood loss, and weight of the resected lung were measured. The thermal effect on the lung tissue was examined by means of intraoperative thermography and histology.
    A total of 12 lung wedge resections were performed in each group. For an equivalent length of operation and weight of the resected lung parenchyma, Group A showed significantly lower blood loss and lower maximum and minimum temperatures of the lung tissue, as assessed by thermography, than Group B. The degree of thermal injury as estimated by a histological examination was lower in Group A than in Group B.
    Our study suggests that the LigaSure system may be superior to conventional electrocautery, indicating its clinical usefulness for non-anatomic pulmonary resection.

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  • Detection of airway ischaemic damage after lung transplantation by using autofluorescence imaging bronchoscopy Reviewed International journal

    Norichika Iga, Takahiro Oto, Masanori Okada, Masaaki Harada, Hitoshi Nishikawa, Kentaroh Miyoshi, Shinji Otani, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka, Shinichiro Miyoshi

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   45 ( 3 )   509 - 513   2014.3

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    OBJECTIVES: Airway complications related to ischaemia are a major cause of morbidity after lung transplantation. Early detection of airway ischaemia and optimal management of the anastomotic site could reduce the risk of airway complications. Autofluorescence imaging (AFI) bronchoscopy has been increasingly recognized as an effective technique for detecting abnormal mucosal thickening. The aim of this study was to investigate whether AFI bronchoscopy can facilitate the detection of airway ischaemic damage in lung transplant patients.
    METHODS: Twenty Landrace pigs were used to create a tracheal autotransplantation model. A four-ring length of trachea was excised and implanted orthotopically. The tracheal autograft was observed on postoperative days 0, 2, 4 and 7 with AFI bronchoscopy. The extent and origin of graft autofluorescence were examined using histology and measured according to fluorescence intensity.
    RESULTS: The lesions on the tracheal autografts appeared as bright green fluorescence on AFI bronchoscopy. On confocal fluorescence microscopy, high-intensity green fluorescence was observed in the elastin fibre layer of the submucosa. The fluorescence intensity of elastin was significantly higher in the graft showing fluorescence than the graft that did not show fluorescence and that at the control site.
    CONCLUSIONS: Bright green fluorescence was seen in an elastin fibre layer in the submucosa, which was likely a result of epithelial sloughing. There is a close relationship between the bright green fluorescence pattern observed using AFI bronchoscopy and airway ischaemic damage. We conclude that AFI bronchoscopy may detect airway ischaemic damage after lung transplantation.

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  • [The role of 18F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) in liposarcoma of the chest wall]. Reviewed

    Haruchika Yamamoto, Seiichiro Sugimoto, Kentaroh Miyoshi, Hiromasa Yamamoto, Junichi Soh, Masaomi Yamane, Shinichi Toyooka, Takahiro Oto, Shinichiro Miyoshi

    Kyobu geka. The Japanese journal of thoracic surgery   67 ( 1 )   4 - 8   2014.1

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    18F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT)imaging is valuable in biopsy guidance, response assessment, grading, follow-up and prognostication for soft-tissue sarcoma. In liposarcoma, the maximum standardized uptake value (SUVmax) on PET/CT scan is correlated with the histological subtypes. We briefly review the role of FDG PET/CT in liposarcoma, and describe a case of chest wall liposarcoma treated based on the assessment with PET/CT. A 76-year-old man, with a 10-cm tumor at the thoracic outlet of the right chest wall, underwent the complete resection of the tumor according to the assessment with PET/CT that showed high FDG uptakeonly in the central area of the tumor with SUVmax of 5.89, but low uptake in the peripheral area. In accordance with the PET/CT findings, pathological examination revealed dedifferentiated liposarcoma in the central area and well-differentiated liposarcoma in the peripheral area. Pretherapy PET/CT should be performed for the appropriate treatment of liposarcoma.

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  • Thoracoscopic Lobectomy as Salvage Surgery for Local Recurrence of Non-Small Cell Lung Cancer after Carbon Ion Radiotherapy in an Initially Operable Patient Reviewed

    Seiichiro Sugimoto, Shinichi Toyooka, Ken Suzawa, Kouichi Ichimura, Osamu Fujii, Shinichiro Miyoshi

    ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY   20   501 - 504   2014

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    Carbon ion radiotherapy (CIRT) for patients with early-stage non-small cell lung cancer (NSCLC) has recently provided favorable local control with very few toxic reactions. Because CIRT for NSCLC has been mostly performed for elderly or inoperable patients, salvage surgery for NSCLC after CIRT has rarely been reported. We describe a case of complete thoracoscopic right upper lobectomy with mediastinal lymphadenectomy performed as salvage surgery for local recurrence of stage IA NSCLC after CIRT in an initially operable patient who had refused surgery 27 months previously. Pleural adhesions caused by CIRT were localized to the pulmonary apex and the central pulmonary structures were intact at the time of the salvage surgery, which allowed us to successfully perform thoracoscopic lobectomy without any complications. Thus, salvage surgery for NSCLC after CIRT may be feasible in an initially operable patient, as CIRT appears to be unlikely to cause any difficulties in the salvage surgery.

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  • Sacrificing the pulmonary arterial branch to the spared lobe is a risk factor of bronchopleural fistula in sleeve lobectomy after chemoradiotherapy Reviewed International journal

    Shinichi Toyooka, Junichi Soh, Kazuhiko Shien, Seiichiro Sugimoto, Masaomi Yamane, Takahiro Oto, Hiroshi Date, Shinichiro Miyoshi

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   43 ( 3 )   568 - 572   2013.3

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    A sleeve lobectomy is a widely accepted procedure for enabling the pulmonary parenchyma to be spared. Induction chemoradiotherapy (CRT) followed by surgery is one treatment option for locally advanced non-small cell lung cancer (NSCLC), but CRT is considered to have a negative effect on subsequent surgery, especially for anastomotic healing. In this study, we describe our experience performing sleeve lobectomies and the associated anastomotic complications after induction CRT.
    The medical records of NSCLC patients who underwent surgery after receiving CRT were reviewed. The relationships between anastomotic complications and clinicopathological factors were examined.
    Between December 1998 and October 2011, a total of 104 patients received CRT followed by surgery. Among them, 14 NSCLC patients underwent a bronchial sleeve resection: nine patients underwent a right upper lobe resection, two patients underwent a left lingular division and lower lobe resection and one patient each underwent a right lower lobe, a right upper and middle lobe and a right middle and lower lobe resection. A bronchopleural fistula at the anastomosis occurred in two patients. A pulmonary arterial (PA) branch to the spared lobe had been sacrificed in both of these patients because of tumour involvement. In contrast, the PA branches to the spared lobes were preserved in 11 of the 12 patients who did not exhibit anastomotic complications (P = 0.033).
    Our experience strongly suggests that the sacrifice of the PA branch to the spared lobe is a possible risk factor for anastomotic complications for a sleeve lobectomy after induction CRT.

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  • 「COPDの集学的治療」嚢胞性肺疾患に対する肺移植治療

    岡田真典, 大藤剛宏, 伊賀徳周, 原田昌明, 西川仁士, 中谷文, 三好健太郎, 大谷真二, 杉本誠一郎, 宗淳一, 山根正修, 豊岡伸一, 三好新一郎

    日本気胸・嚢胞性肺疾患学会雑誌   12 ( 2 )   121 - 124   2012.11

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  • Outcome of living-donor lobar lung transplantation using a single donor Reviewed International journal

    Hiroshi Date, Takeshi Shiraishi, Seiichiro Sugimoto, Tsuyoshi Shoji, Fengshi Chen, Masafumi Hiratsuka, Akihiro Aoyama, Masaaki Sato, Masaomi Yamane, Akinori Iwasaki, Shinichiro Miyoshi, Toru Bando, Takahiro Oto

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY   144 ( 3 )   710 - 715   2012.9

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    Objective: Living-donor lobar lung transplantation usually requires 2 healthy donors who donate either a right or a left lower lobe; however, finding 2 healthy donors is difficult. Several case reports have been published on successful living-donor lobar lung transplantation using a single donor; however, little is known about its outcome.
    Methods: We retrospectively investigated 14 critically ill patients who had undergone single living-donor lobar lung transplantation at 3 lung transplant centers in Japan. There were 10 female and 4 male patients, including 10 children and 4 adults. Size matching was assessed by estimated graft forced vital capacity and 3-dimensional computed tomography volumetry. The diagnoses included complications of allogeneic hematopoietic stem cell transplantation (n = 6), pulmonary hypertension (n = 4), and others (n = 4).
    Results: At a mean follow-up of 45 months (range, 2-128), the 3- and 5-year survival rate was 70% and 56%, respectively. There were 4 early deaths, for a hospital mortality of 29%, with 1 additional death at 40 months. The main cause of early death was primary graft dysfunction, most likely related to size mismatching. The survival among these 14 patients was significantly worse than the survival in a group of 78 patients undergoing bilateral living-donor lobar lung transplantation during the same period (P = .044).
    Conclusions: Single living-donor lobar lung transplantation provides acceptable results for sick patients who would die soon otherwise. However, bilateral living-donor lobar lung transplantation appears to be a better option if 2 living donors are found. (J Thorac Cardiovasc Surg 2012; 144: 710-5)

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  • Intrathoracic irrigation with arbekacin for methicillin-resistant Staphylococcus aureus empyema following lung resection Reviewed International journal

    Tsuyoshi Ueno, Shinichi Toyooka, Junichi Soh, Kentaroh Miyoshi, Seiichiro Sugimoto, Masaomi Yamane, Takahiro Oto, Shinichiro Miyoshi

    INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY   15 ( 3 )   437 - 441   2012.9

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    OBJECTIVES: Empyema is a well-known complication following lung resection. In particular, empyema caused by methicillin-resistant Staphylococcus aureus (MRSA) is difficult to treat. Here, we present our experience of MRSA empyema treated with local irrigation using arbekacin.
    METHODS: Six patients consisted of 4 males and 2 females with an average age of 65.7 years. They developed MRSA empyema following lung resection and were treated at our institution between 2007 and 2011. Cases comprised four primary and one metastatic lung cancer, and 1 patient was a living lung transplantation donor. The surgical procedure consisted of four lobectomies, one segmentectomy and one wedge resection. After diagnosis of MRSA empyema, anti-MRSA drugs were administered intravenously in all cases. In addition, arbekacin irrigation at a dose of 100 mg dissolved in saline was performed after irrigation with saline only.
    RESULTS: The average number of postoperative days for the diagnosis of MRSA empyema was 13 (range 4-19). The period of irrigation ranged from 6 to 46 days. Arbekacin irrigation did not induce nephrotoxicity or other complications, and no bacteria resistant to arbekacin was detected in the thoracic cavity. We re-operated on 1 case because he had pulmonary fistula and severe wound infection. At the time of removing the thoracic catheter, MRSA in the pleural effusion disappeared completely in 3 patients. The period until MRSA concentration in the pleural effusion became negative after starting arbekacin irrigation ranged from 4 to 9 days. In the remaining cases, in which MRSA did not disappear, the catheter was removed because of no inflammatory reaction after stopping irrigation and clamping the catheters. All patients were discharged from our institution without thoracic catheterization and no patients had relapsed during the follow-up period ranging from 6 to 44 months.
    CONCLUSIONS: Irrigation of the thoracic cavity with arbekacin proved to be an effective, safe and readily available method for treating MRSA empyema following lung resection.

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  • [Primary mediastinal lymphoma; a clinicopathologic case series]. Reviewed

    Seiichiro Sugimoto, Junichi Soh, Yuho Maki, Takeshi Kurosaki, Masaomi Yamane, Shinichi Toyooka, Takahiro Oto, Shinichiro Miyoshi

    Kyobu geka. The Japanese journal of thoracic surgery   65 ( 7 )   527 - 31   2012.7

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    Treatment for primary mediastinal lymphoma generally involves chemotherapy and radiotherapy, and treatment regimens depend on histologic subtypes of lymphoma. The histologic subtype of lymphoma is mostly determined by computed tomography (CT)-guided core-needle biopsy or surgical procedures, including thoracotomy, thoracoscopy and mediastinoscopy. We describe the clinicopathologic features and diagnostic procedures of 8 cases of primary mediastinal lymphoma. The male-to-female ratio was 1:1, and median age at diagnosis was 27 years. The median size of the primary mediastinal tumor on CT was 8.5 cm. Five patients were diagnosed by CT-guided core-needle biopsy, 1 by open biopsy and 2 by surgery. Three patients were diagnosed with nodular sclerosis Hodgkin lymphoma, 3 with mediastinal diffuse large B-cell lymphoma, 1 with precursor T-lymphoblastic leukemia/lymphoma and 1 with thymic extranodal marginal zone B-cell lymphoma. According to their histological subtypes, 5 patients were treated with chemoradiotherapy, 2 patients with chemotherapy and 1 patient of thymic extranodal marginal zone B-cell lymphoma with surgery alone. All patients survived in the median follow-up of 34.5 months. Appropriate biopsy procedure should be performed in patients with suspected mediastinal lymphoma.

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  • A Case of Delayed Massive Hemothorax Caused by the Rupture of a Pulmonary Artery Pseudoaneurysm after Radiofrequency Ablation of Lung Tumors Reviewed International journal

    Junichi Soh, Shinichi Toyooka, Hideo Gobara, Takao Hiraki, Seiichiro Sugimoto, Masaomi Yamane, Takahiro Oto, Susumu Kanazawa, Shinichiro Miyoshi

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   42 ( 7 )   646 - 649   2012.7

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    Radiofrequency ablation has been applied as a minimally invasive therapy for the local control of lung tumors, including primary and metastatic neoplasms. Hemorrhagic complications after radiofrequency ablation can usually be treated conservatively, but such complications can be massive and fatal in some cases. In this paper, we report the rare case of delayed massive hemothrax caused by the rupture of a pulmonary artery pseudoaneurysm after lung radiofrequency ablation that was treated using transcatheter coil embolization followed by a left lower lobectomy. A 75-year-old woman underwent radiofrequency ablation for the treatment of a metastatic lung tumor in the left lower lobe arising from a colorectal carcinoma located close to a branch of the pulmonary artery. Thirty-six hours later, hemothorax and hemorrhagic shock occurred as a result of a ruptured pulmonary artery pseudoaneurysm and radiofrequency ablation-induced damage to the interlobular pleura. After transcatheter coil embolization of the pulmonary artery pseudoaneurysm, she recovered from a state of shock and a left lower lobectomy was performed. Histological findings revealed the presence of residual tumor cells in the ablated lung tumor. The postoperative course was uneventful, and no evidence of recurrence of the primary disease was seen at 1 year after the surgery. Although hemothorax secondary to the rupture of a pulmonary artery pseudoaneurysm after lung radiofrequency ablation is a rare complication, it should be recognized as a serious potential complication of lung radiofrequency ablation for a tumor located close to the pulmonary artery branch.

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  • 「高齢化社会を迎えての臓器移植の展望:高齢ドナー移植の現状と問題」肺移植における高齢ドナー

    大藤剛宏, 三好健太郎, 杉本誠一郎, 山根正修, 三好新一郎

    移植   47 ( 2/3 )   161 - 165   2012.6

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  • Five-year update on the mouse model of orthotopic lung transplantation: Scientific uses, tricks of the trade, and tips for success Reviewed International journal

    Xue Lin, Wenjun Li, Jiaming Lai, Mikio Okazaki, Seiichiro Sugimoto, Sumiharu Yamamoto, Xingan Wang, Andrew E. Gelman, Daniel Kreisel, Alexander Sasha Krupnick

    JOURNAL OF THORACIC DISEASE   4 ( 3 )   247 - 258   2012.6

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    It has been 5 years since our team reported the first successful model of orthotopic single lung transplantation in the mouse (1). There has been great demand for this technique due to the obvious experimental advantages the mouse offers over other large and small animal models of lung transplantation. These include the availability of mouse-specific reagents as well as knockout and transgenic technology. Our laboratory has utilized this mouse model to study both immunological and non-immunological mechanisms of lung transplant physiology while others have focused on models of chronic rejection (1-19). It is surprising that despite our initial publication in 2007 only few other laboratories have published data using this model (20-25). This is likely due to the technical complexity of the surgical technique and perioperative complications, which can limit recipient survival (9,26). As two of the authors (XL and WL) have a combined experience of over 2500 left and right single lung transplants, this review will summarize their experience and delineate tips and tricks necessary for successful transplantation. We will also describe technical advances made since the original description of the model (1,5,6).

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  • Egr1: a novel target for ameliorating acute allograft rejection in an experimental lung transplant model Reviewed International journal

    Naohisa Waki, Masaomi Yamane, Sumiharu Yamamoto, Mikio Okazaki, Seiichiro Sugimoto, Akihiro Matsukawa, Takahiro Oto, Shinichiro Miyoshi

    EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY   41 ( 3 )   669 - 675   2012.3

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    Acute allograft rejection is one of the significant complications occurring in lung transplant recipients. Early growth response-1 (Egr-1), zinc-finger-type transcription factor, is known as a master switch regulator of diverse chemical mediators. We used an orthotopic mouse model of left lung transplant to elucidate the function of Egr-1 in acute pulmonary rejection.
    Left lung grafts retrieved from C57BL/6 wild mice or C57BL/6 Egr-1-null mice were orthotopically transplanted into BALB/c mice; the lungs were harvested at day 1, 3, 5 or 7 after lung transplantation. The grade of acute rejection was histopathologically evaluated. The intragraft gene expression levels of Egr-1 and downstream target mediators were quantitatively measured by real-time polymerase chain reaction. Immunohistochemical analysis was used to determine the location and distribution of the Egr-1 protein in the pulmonary graft.
    Severe acute rejection was observed in allografts from wild-type mice at 5 days after transplantation. Only minimal rejection was seen in the lung graft from Egr-1-null donor mice at 5 days after transplantation. Strong upregulation of Egr-1 mRNA transcripts was observed at day 1, which then decreased during the next 5 days. The mRNA of Egr-1 target mediators [interleukin-1-beta (IL-1 beta), monocyte chemotactic protein-1 (MCP-1) and plasminogen activator inhibitor-1] reached maximal levels at day 5. Egr-1-null allografts exhibited significantly lower expressions of IL-1 beta and MCP-1 mRNA (P &lt; 0.05).
    Our study showed that deletion of Egr-1 in lung allografts ameliorates severe acute rejection with the reduction of expression levels of chemical mediators, implying a new possible strategy for treating acute pulmonary allograft rejection.

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  • 「切除困難例」への化学療法後の手術―根治切除はどこまで可能か 非小細胞肺癌に対する根治的放射線化学療法後の手術

    豊岡伸一, 宗淳一, 枝園和彦, 牧佑歩, 三好健太郎, 上野剛, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    臨床外科   67 ( 1 )   12 - 16   2012.1

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  • Emergency granulopoiesis promotes neutrophil-dendritic cell encounters that prevent mouse lung allograft acceptance Reviewed International journal

    Daniel Kreisel, Seiichiro Sugimoto, Jihong Zhu, Ruben Nava, Wenjun Li, Mikio Okazaki, Sumiharu Yamamoto, Mohsen Ibrahim, Howard J. Huang, Kelsey A. Toth, Jon H. Ritter, Alexander S. Krupnick, Mark J. Miller, Andrew E. Gelman

    BLOOD   118 ( 23 )   6172 - 6182   2011.12

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    The mechanisms by which innate immune signals regulate alloimmune responses remain poorly understood. In the present study, we show by intravital 2-photon microscopy direct interactions between graft-infiltrating neutrophils and donor CD11c(+) dendritic cells (DCs) within orthotopic lung allografts immediately after reperfusion. Neutrophils isolated from the airways of lung transplantation recipients stimulate donor DCs in a contact-dependent fashion to augment their production of IL-12 and expand alloantigen-specific IFN-gamma(+) T cells. DC IL-12 expression is largely regulated by degranulation and induced by TNF-alpha associated with the neutrophil plasma membrane. Extended cold ischemic graft storage enhances G-CSF-mediated granulopoiesis and neutrophil graft infiltration, resulting in exacerbation of ischemia-reperfusion injury after lung transplantation. Ischemia reperfusion injury prevents immunosuppression-mediated acceptance of mouse lung allografts unless G-CSF-mediated granulopoiesis is inhibited. Our findings identify granulopoiesis-mediated augmentation of alloimmunity as a novel link between innate and adaptive immune responses after organ transplantation. (Blood. 2011;118(23):6172-6182)

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  • 縦隔リンパ節転移を伴った肺癌に対する外科的治療をめぐって 3.術前化学療法後外科的治療 1)術前放射線化学療法における外科治療の役割

    豊岡伸一, 宗淳一, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本胸部臨床   70 ( 9 )   919 - 924   2011.9

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  • 法改正後の移植の現状と問題点:心肺領域 マージナル肺ドナーとメディカルコンサルタント

    大藤剛宏, 三好健太郎, 杉本誠一郎, 山根正修, 三好新一郎

    移植   46 ( 4/5 )   281 - 283   2011.9

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  • 治療抵抗性特発性間質性肺炎に対する生体肺移植

    三好健太郎, 大藤剛宏, 大谷真二, 杉本誠一郎, 宗淳一, 山根正修, 豊岡伸一, 三好新一郎

    臨床呼吸生理   43   47 - 49   2011.6

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  • A novel technique for identification of the lung intersegmental plane using dye injection into the segmental pulmonary artery Reviewed International journal

    Seiichiro Sugimoto, Takahiro Oto, Kentaroh Miyoshi, Shinichiro Miyoshi

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY   141 ( 5 )   1325 - 1327   2011.5

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  • Maintenance of IKK beta Activity Is Necessary to Protect Lung Grafts From Acute Injury Reviewed International journal

    Howard J. Huang, Seiichiro Sugimoto, Jiaming Lai, Mikio Okazaki, Sumiharu Yamamoto, Alexander S. Krupnick, Daniel Kreisel, Andrew E. Gelman

    TRANSPLANTATION   91 ( 6 )   624 - 631   2011.3

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    Background. Signaling pathways that target I-kappa B kinase beta (IKK beta) activation stimulate the expression of nuclear factor (NF)-kappa B-dependent genes and are thus believed to primarily promote inflammation and injury in solid organ grafts.
    Methods. We examined the role of IKK beta in a mouse model of lung transplantation-mediated ischemia-reperfusion injury using NF-kappa B essential modulator (NEMO)-binding domain (NBD) peptide to pharmacologically inhibit IKK activation. As myeloid cells are primarily responsible for the production of acute inflammatory mediators after lung transplantation, we also investigated the effects of myeloid cell-specific IKK beta gene deletion on acute lung graft injury by transplanting mutant mice.
    Results. When NBD was administered at a dose that partially inhibits IKK beta activation, we observed attenuated lung graft injury and blunted expression of intragraft proinflammatory mediators. Surprisingly, when the dose of NBD was increased to a level that ablates intragraft IKK beta activation, graft inflammation, and injury were significantly worse compared with recipients treated with control peptide. Similar to lung recipients with pharmacologically ablated IKK beta activity, donor-recipient transplant combinations with a myeloid cell-specific IKK beta gene deletion had marked intragraft inflammation and poor lung function.
    Conclusions. Our data show maintenance of IKK beta activity is critical for promoting graft homeostasis with important implications for targeting NF-kappa B-dependent signaling pathways for treating acute lung injury.

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  • Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis Reviewed International journal

    Daniel Kreisel, Seiichiro Sugimoto, Jeremy Tietjens, Jihong Zhu, Sumiharu Yamamoto, Alexander S. Krupnick, Ruaidhri J. Carmody, Andrew E. Gelman

    JOURNAL OF CLINICAL INVESTIGATION   121 ( 1 )   265 - 276   2011.1

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    Granulocytes are pivotal regulators of tissue injury However, the transcriptional mechanisms that regulate granulopoiesis under inflammatory conditions are poorly understood Here we show that the transcriptional coregulator B cell leukemia/lymphoma 3 (Bcl3) limits granulopoiesis under emergency e, inflammatory) conditions, but not homeostatic conditions Treatment of mouse myeloid progenitors with G-CSF serum concentrations of which rise under inflammatory conditions rapidly increased Bcl3 transcript accumulation in a STAT3-dependent manner Bcl3-deficient myeloid progenitors demonstrated an enhanced capacity to proliferate and differentiate into granulocytes following G-CSF stimulation, whereas the accumulation of Bcl3 protein attenuated granulopoiesis in an NF-kappa B p50-dependent manner In a clinically relevant model of transplant-mediated lung ischemia reperfusion injury, expression of Bcl3 in recipients inhibited emergency granulopoiesis and limited acute graft damage These data demonstrate a critical role for Bcl3 in regulating emergency granulopoiesis and suggest that targeting the differentiation of myeloid progenitors may be a therapeutic strategy for preventing inflammatory lung injury

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  • Surgery after induction chemoradiotherapy

    Toyooka, S., Soh, J., Sugimoto, S., Yamane, M., Oro, T., Miyoshi, S.

    Japanese Journal of Chest Diseases   70 ( 9 )   2011

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  • A case of ileal perforation of malignant lymphoma occurring after lung transplantation

    Muraoka, T., Asano, H., Tsukuda, K., Sawada, Y., Nogami, T., Ueno, T., Maki, Y., Sugimoto, S., Toyooka, S., Naito, M.

    Japanese Journal of Gastroenterological Surgery   44 ( 12 )   1610 - 1617   2011

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    We encountered a case of malignant lymphoma of the small intestine under medication with tacrolimus after lung transplantation. A 22-year-old man suffered from drug-induced interstitial pneumonia caused by having taken methotrexate for juvenile idiopathic arthritis since age 16. The patient received bilateral lungs transplantation from a brain-dead donor. Tacrolimus had been used for immune suppression. Six months after the lung transplantation, ileal malignant lymphoma (diffuse large B-cell lymphoma), one of the posttransplant lymphoproliferative disorders, occurred. Five days after rituximab administration was initiated, massive intestinal hemorrhage from the tumor occurred. Immediately after colono-scopic hemostasis intra-abdominal free air appeared. Emergency laparotomy was performed under a diagnosis of gastrointestinal perforation. Though the ileum where the hemostasis had been performed was not perforated, a site in the ileum 120 cm from the ligament of Treitz was perforated. We resected both the perforated site and the ileocecum where lymphoma was excised. The patient died from exacerbation of the malignant lymphoma on the 52nd day after the operation. © 2011 The Japanese Society of Gastroenterological Surgery.

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  • 乳糜胸水・腹水を考える―その原因と対策〔術後合併症としての乳糜胸水・腹水―対応に困ったこの症例〕胸部外科系術後の乳糜胸水 肺リンパ脈管筋腫症(LAM)患者に合併した術後乳糜胸水

    二萬英斗, 大藤剛宏, 杉本誠一郎, 宗淳一, 山根正修, 豊岡伸一, 三好新一郎

    臨床外科   65 ( 10 )   1372 - 1375   2010.10

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  • Cutting Edge: MHC Class II Expression by Pulmonary Nonhematopoietic Cells Plays a Critical Role in Controlling Local Inflammatory Responses Reviewed International journal

    Daniel Kreisel, Steven B. Richardson, Wenjun Li, Xue Lin, Christopher G. Kornfeld, Seiichiro Sugimoto, Chyi-Song Hsieh, Andrew E. Gelman, Alexander S. Krupnick

    JOURNAL OF IMMUNOLOGY   185 ( 7 )   3809 - 3813   2010.10

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    The interaction of CD4(+) T cells with MHC class II (MHCII)-expressing hematopoietic APCs plays a critical role in both the generation of protective immune responses and maintenance of tolerance in the lung. The functional significance of MHCII expression by nonhematopoietic stromal cells, however, has not been defined in vivo. Using a novel mouse model of orthotopic left lung transplantation, we demonstrate that selective elimination of MHCII expression on nonhematopoietic cells leads to an inflammatory response as a result of reduced peripheral generation of regulatory CD4(+) T cells. Absence of MHCII expression on nonhematopoietic cells also inhibits local growth of metastatic pulmonary tumor. These findings indicate that nonhematopoietic cells play a previously unrecognized role in downregulating inflammatory responses in nonlymphoid tissues. The Journal of Immunology, 2010, 185: 3809-3813.

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  • 診療に役立つ「呼吸器疾患外科治療」のすべて I 良性疾患 7.肺気腫に対するvolume reduction surgery

    杉本誠一郎, 大藤剛宏, 宗淳一, 山根正修, 豊岡伸一, 三好新一郎

    日本胸部臨床   69 ( 9 )   S40-S44 - S44   2010.9

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  • 肺癌 肺癌の治療指針とその戦略 非小細胞肺癌の治療戦略肺癌外科手術―適応,手術手技,治療成績―

    杉本誠一郎, 豊岡伸一, 三好新一郎

    Medical Practice   27 ( 7 )   1181 - 1185   2010.7

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  • Orthotopic vascularized right lung transplantation in the mouse Reviewed International journal

    Wenjun Li, Seiichiro Sugimoto, Jiaming Lai, G. Alexander Patterson, Andrew E. Gelman, Alexander S. Krupnick, Daniel Kreisel

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY   139 ( 6 )   1637 - 1643   2010.6

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    Objectives: Orthotopic left lung transplantation in the mouse, as recently developed by our laboratory, represents a physiologic model for studies in transplantation biology. However, because of the limited overall respiratory contribution of the murine left lung, left lung transplant recipients remain healthy despite immune-mediated graft necrosis. We sought to develop a lung transplantation model in which animal survival depends on graft function.
    Methods: Orthotopic vascularized right lung transplantations using cuff techniques were performed in syngeneic and allogeneic strain combinations. Grafts were assessed histologically or functionally by measuring arterial blood gases from 7 to 28 days after transplantation. In a parallel set of experiments, syngeneic and immunosuppressed allogeneic hosts underwent a left pneumonectomy 2 weeks after right lung transplantation, with assessment of graft function 1 week later.
    Results: We performed 40 right lung transplantations, with a survival rate of 87.5%. Syngeneic grafts remain free of inflammation as far as 28 days after transplantation. On day 7, arterial oxygen levels in syngeneic recipients (481 +/- 90 mm Hg) are equivalent to those in naive mice (503 +/- 59 mm Hg) after left hilar occlusion. Alternatively, allogeneic grafts develop histologic evidence of acute rejection, and arterial oxygen levels are significantly decreased after left hilar clamping (53.3 +/- 10.3 mm Hg). Both syngeneic and immunosuppressed allogeneic right lung recipients tolerate a left pneumonectomy.
    Conclusions: Right lung transplantation followed by left pneumonectomy represents the first survival model of vascularized lung transplantation in the mouse and will therefore allow for the design of novel studies in experimental lung transplantation. (J Thorac Cardiovasc Surg 2010;139:1637-43)

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  • CCR2 regulates monocyte recruitment as well as CD4+ T <inf>h</inf>1 allorecognition after lung transplantation

    A. E. Gelman, M. Okazaki, S. Sugimoto, W. Li, C. G. Kornfeld, J. Lai, S. B. Richardson, F. H. Kreisel, H. J. Huang, J. R. Tietjens, B. H. Zinselmeyer, G. A. Patterson, M. J. Miller, A. S. Krupnick, D. Kreisel

    American Journal of Transplantation   10 ( 5 )   1189 - 1199   2010.5

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    Graft rejection remains a formidable problem contributing to poor outcomes after lung transplantation. Blocking chemokine pathways have yielded promising results in some organ transplant systems. Previous clinical studies have demonstrated upregulation of CCR2 ligands following lung transplantation. Moreover, lung injury is attenuated in CCR2-deficient mice in several inflammatory models. In this study, we examined the role of CCR2 in monocyte recruitment and alloimmune responses in a mouse model of vascularized orthotopic lung transplantation. The CCR2 ligand MCP-1 is upregulated in serum and allografts following lung transplantation. CCR2 is critical for the mobilization of monocytes from the bone marrow into the bloodstream and for the accumulation of CD11c+ cells within lung allografts. A portion of graft-infiltrating recipient CD11c+ cells expresses both recipient and donor MHC molecules. Two-photon imaging demonstrates that recipient CD11c+ cells are associated with recipient T cells within the graft. While recipient CCR2 deficiency does not prevent acute lung rejection and is associated with increased graft infiltration by T cells, it significantly reduces CD4+ Th1 indirect and direct allorecognition. Thus, CCR2 may be a potential target to attenuate alloimmune responses after lung transplantation. © 2010 The American Society of Transplantation and the American Society of Transplant Surgeons.

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  • Volume reduction surgery for pulmonary emphysema

    Sugimoto, S., Oto, T., Soh, J., Yamane, M., Toyooka, S., Miyoshi, S.

    Japanese Journal of Chest Diseases   69 ( SUPPL. )   2010

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  • Apyrase treatment prevents ischemia-reperfusion injury in rat lung isografts Reviewed International journal

    Seiichiro Sugimoto, Xue Lin, Jiaming Lai, Mikio Okazaki, Nitin A. Das, Wenjun Li, Alexander S. Krupnick, Ridong Chen, Soon Seog Jeong, G. A. Patterson, Daniel Kreisel, Andrew E. Gelman

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY   138 ( 3 )   752 - 759   2009.9

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    Objective: Endothelial cells express the ectoenzyme ectonucleoside adenosine triphosphate diphosphohydrolase, an apyrase that inhibits vascular inflammation by catalyzing the hydrolysis of adenosine triphosphate and adenosine diphosphate. However, ectonucleoside adenosine triphosphate diphosphohydrolase expression is rapidly lost following oxidative stress, leading to the potential for adenosine triphosphate and related purigenic nucleotides to exacerbate acute solid organ inflammation and injury. We asked if administration of a soluble recombinant apyrase APT102 attenuates lung graft injury in a cold ischemia reperfusion model of rat syngeneic orthotopic lung transplantation.
    Methods: Male Fisher 344 donor lungs were cold preserved in a low-potassium dextrose solution in the presence or absence of APT102 for 18 hours prior to transplantation into syngeneic male Fisher 344 recipients. Seven minutes after reperfusion, lung transplant recipients received either a bolus of APT102 or vehicle (saline solution). Four hours after reperfusion, APT102- and saline solution-treated groups were evaluated for lung graft function and inflammation.
    Results: APT102 significantly reduced lung graft extracellular pools of adenosine triphosphate and adenosine diphosphate, improved oxygenation, and protected against pulmonary edema. Apyrase treatment was associated with attenuated neutrophil graft sequestration and less evidence of tissue inflammation as assessed by myeloperoxidase activity, expression of proinflammatory mediators, and numbers of apoptotic endothelial cells.
    Conclusions: Administration of a soluble recombinant apyrase promotes lung function and limits the tissue damage induced by prolonged cold storage, indicating that extracellular purigenic nucleotides play a key role in promoting ischemia-reperfusion injury following lung transplantation.

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  • Experimental orthotopic lung transplantation model in rats with cold storage Reviewed

    Ryujiro Sugimoto, Atsunori Nakao, Itaru Nagahiro, Junichi Kohmoto, Seiichiro Sugimoto, Mikio Okazaki, Masaomi Yamane, Hidetoshi Inokawa, Takahiro Oto, Kazunori Tahara, Jianghua Zhan, Yoshifumi Sano, Kenneth R. McCurry

    SURGERY TODAY   39 ( 7 )   641 - 645   2009.7

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    This report describes a new experimental procedure, a rat unilateral, orthotopic lung transplantation with cold storage, and evaluates its relevancy and reliability to study the early events during cold ischemia/reperfusion (I/R) injury. This model, using the cuff technique, does not require extensive training and is relatively easy to be established. The model can induce reproducible degrees of pulmonary graft injury including impaired gas exchange, proinflammatory cytokine upregulation, or inflammatory infiltrates, depending on the preservation time. The results are consistent with the previous clinical evidence, thus suggesting that this model is a valid and reliable animal model of cold I/R injury.

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  • Cutting Edge: Acute Lung Allograft Rejection Is Independent of Secondary Lymphoid Organs Reviewed International journal

    Andrew E. Gelman, Wenjun Li, Steven B. Richardson, Bernd H. Zinselmeyer, Jiaming Lai, Mikio Okazaki, Christopher G. Kornfeld, Friederike H. Kreisel, Seiichiro Sugimoto, Jeremy R. Tietjens, John Dempster, G. Alexander Patterson, Alexander S. Krupnick, Mark J. Miller, Daniel Kreisel

    JOURNAL OF IMMUNOLOGY   182 ( 7 )   3969 - 3973   2009.4

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    It is the prevailing view that adaptive immune responses are initiated in secondary lymphoid organs. Studies using alymphoplastic mice have shown that secondary lymphoid organs are essential to initiate allograft rejection of skin, heart, and small bowel. The high immunogenicity of lungs is well recognized and allograft rejection remains a major contributing factor to poor outcomes after lung transplantation. We show in this study that alloreactive T cells are initially primed within lung allografts and not in secondary lymphoid organs following transplantation. In contrast to other organs, lungs are acutely rejected in the absence of secondary lymphoid organs. Two-photon microscopy revealed that recipient T cells cluster predominantly around lung-resident, donor-derived CD11c(+) cells early after engraftment. These findings demonstrate for the first time that alloimmune responses following lung transplantation are initiated in the graft itself and therefore identify a novel, potentially clinically relevant mechanism of lung allograft rejection. The Journal of Immunology, 2009, 182: 3969-3973.

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  • Orthotopic mouse lung transplantation as experimental methodology to study transplant and tumor biology Reviewed International journal

    Alexander S. Krupnick, Xue Lin, Wenjun Li, Mikio Okazaki, Jiaming Lai, Seiichiro Sugimoto, Steven B. Richardson, Christopher G. Kornfeld, Joel R. Garbow, G. Alexander Patterson, Andrew E. Gelman, Daniel Kreisel

    NATURE PROTOCOLS   4 ( 1 )   86 - 93   2009

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    Unlike transplantation of other solid organs, vascularized mouse lung transplantation has only recently been developed. In this protocol, we describe a detailed method for performing a vascularized and aerated mouse orthotopic lung transplant, which to date represents the most physiological mouse model of lung transplantation. The procedure is divided into two separate portions consisting of donor harvest followed by implantation using the cuff technique for bronchovascular anastomoses. After a training period spanning several months, the procedure can be successfully mastered and, in experienced hands, requires similar to 90 min to perform. After an initial learning curve, perioperative survival is close to 100%. As the donor hematopoietic cells in the transplanted lung are replaced by those of the host over time, thereby creating a &apos;chimeric lung,&apos; this model represents a novel research tool for the study of transplantation biology as well as other disease processes, such as malignancies.

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  • Costimulatory Blockade-Mediated Lung Allograft Acceptance Is Abrogated by Overexpression of Bcl-2 in the Recipient

    Okazaki, M., Sugimoto, S., Lai, J., Kornfeld, C.G., Hotchkiss, R.S., Richardson, S.B., Li, W., Kreisel, F.H., Huang, H.J., Patterson, G.A., Krupnick, A.S., Gelman, A.E., Kreisel, D.

    Transplantation Proceedings   41 ( 1 )   385 - 387   2009

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    Lung allografts are considered to be more immunogenic than other solid organs. Little is known about the effectiveness of immunosuppressive regimens after lung transplantation. Herein, we describe a novel model of murine vascularized orthotopic lung transplantation we used to study the effects of costimulatory blockade on lung rejection. Transplants were performed in the Balb → B6 strain combination. Recipients were either not immunosuppressed or received perioperative CD40/CD40L and CD28/B7 costimulatory blockade. Nonimmunosupressed Balb/c → B6 lung transplants had severe acute rejection 7 days after transplantation and CD8+ T cells outnumbered CD4+ T cells within the allografts. Alternatively, B6 recipients that received perioperative costimulatory blockade had minimal inflammation and there were nearly equal numbers of CD8+ and CD4+ T cells in these grafts. Approximately one third of graft-infiltrating CD4+ T cells expressed Foxp3. CD4+ T cells isolated from these grafts induced apoptosis of alloreactive CD8+ T cells that were stimulated with donor splenocytes in vitro. In contrast with wild-type B6 recipient mice, we observed severe rejection of Balb/c lungs 7 days after transplantation into Bcl-2 transgenic B6 recipients that had received costimulatory blockade. CD8+ T cells outnumbered CD4+ T cells in these immunosuppressed Bcl-2 transgenic recipients and, compared with immunosuppressed wild-type B6 recipients, a lower percentage of graft-infiltrating CD4+ T cells expressed Foxp3, and a higher percentage of graft-infiltrating CD8+ T cells expressed intereferon-γ. Thus, our results show that perioperative blockade of the CD40/CD40L and CD28/B7 costimulatory pathways markedly ameliorates acute rejection of lung allografts in wild type but not Bcl-2 transgenic recipients. © 2009 Elsevier Inc. All rights reserved.

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  • Monocyte Differentiation Is Controlled by MyD88 After Mouse Orthotopic Lung Transplantation

    Sugimoto, S., Lin, X., Okazaki, M., Lai, J., Tietjens, J.R., Huang, H., Patterson, G.A., Krupnick, A.S., Kreisel, D., Gelman, A.E.

    Transplantation Proceedings   41 ( 1 )   388 - 390   2009

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    In lung grafts, ischemia-reperfusion signals rapidly induce the recruitment and differentiation of host monocytes into macrophages and dendritic cells. The nature of ischemia-reperfusion signals are antigen independent, but have been hypothesized to initiate Toll-like receptor (TLR) and interleukin (IL)-1R-mediated signaling pathways that are thought to potentiate alloimmune responses. We wondered whether MyD88, an adaptor molecule critical for both TLR and IL-1R-mediated inflammatory responses, regulated monocyte differentiation in a mouse model of vascularized orthotopic lung transplantation. Orthotopic left lung transplants were performed in the following syngeneic combinations: CD45.1+ B6 → CD45.2+ MyD88-/- and CD45.1+ B6 → CD45.2+ B6. One day later, recipient-derived dendritic cells and macrophage numbers were assessed in the bronchiolar lavage by FACS analysis. Compared with the bronchiolar lavage of wildtype recipients, MyD88-/- recipients had lower numbers of dendritic cells in lung graft airways that were of recipient origin. Lower numbers of newly differentiated lung graft dendritic cells was coincident with the appearance of higher numbers of undifferentiated monocytes in the lung airways of MyD88-/- recipients as compared with wild-type recipients. Moreover, adoptive transfer experiments demonstrated that MyD88-/- monocytes were poorer at differentiating into lung dendritic cells as compared with wild-type monocytes. Taken together, these data show that MyD88 regulates graft-infiltrating monocyte differentiation and suggests a mechanism by which TLR/IL-1R-signaling pathways control adaptive responses in lung allografts through controlling monocyte fate. © 2009 Elsevier Inc. All rights reserved.

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  • Native lung-sparing lobar transplantation for pulmonary emphysema Reviewed International journal

    Masaomi Yamane, Daisuke Okutani, Sciichiro Sugimoto, Shinichi Toyooka, Motoi Aoe, Megumi Okazaki, Yoshifumi Sano, Hiroshi Date

    JOURNAL OF HEART AND LUNG TRANSPLANTATION   27 ( 9 )   1046 - 1049   2008.9

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    The living-donor lobar lung transplantation procedure has been developed clinically as an alternative approach for patients considered too ill to await cadaveric transplantation. With this procedure, 2 lobes are implanted in the recipient in place of whole right and left lungs, respectively. However, the shortage of graft volume can be a problem when compared with full-sized cadaveric grafts. In an attempt to solve this problem, we have developed a native lobe-preserving lobar transplant technique using a large animal model. We report a first successful case of a patient undergoing native lobe-preserving lobar lung transplantation for severe pulmonary emphysema.

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  • The feasibility of diaphragmatic transplantation as potential therapy for treatment of respiratory failure associated with Duchenne muscular dystrophy: Acute canine model Reviewed International journal

    Alexander Sasha Krupnick, Andrew E. Gelman, Mikio Okazaki, Jiaming Lai, Nitin Das, Seiichiro Sugimoto, Thomas H. Tung, Steven B. Richardson, G. Alexander Patterson, Daniel Kreisel

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY   135 ( 6 )   1398 - U336   2008.6

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  • CD4(+) T lymphocytes are not necessary for the acute rejection of vascularized mouse lung transplants Reviewed International journal

    Andrew E. Gelman, Mikio Okazaki, Jiaming Lai, Christopher G. Kornfeld, Friederike H. Kreisel, Steven B. Richardson, Seiichiro Sugimoto, Jeremy R. Tietjens, G. Alexander Patterson, Alexander S. Krupnick, Daniel Kreisel

    JOURNAL OF IMMUNOLOGY   180 ( 7 )   4754 - 4762   2008.4

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    Acute rejection continues to present a major obstacle to successful lung transplantation. Although CD4(+) T lymphocytes are critical for the rejection of some solid organ grafts, the role of CD4(+) T cells in the rejection of lung allografts is largely unknown. In this study, we demonstrate in a novel model of orthotopic vascularized mouse lung transplantation that acute rejection of lung allografts is independent of CD4(+) T cell-mediated allorecognition pathways. CD4(+) T cell-independent rejection occurs in the absence of donor-derived graft-resident hematopoietic APCs. Furthermore, blockade of the CD28/B7 costimulatory pathways attenuates acute lung allograft rejection in the absence of CD4(+) T cells, but does not delay acute rejection when CD4(+) T cells are present. Our results provide new mechanistic insight into the acute rejection of lung allografts and highlight the importance of identifying differences in pathways that regulate the rejection of various organs.

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  • 新しい生体肺移植術式:両側自己肺温存部分肺移植術 Bilateral native lung‐sparing lobar transplantation

    杉本誠一郎, 伊達洋至, 杉本龍士郎, 山根正修, 豊岡伸一, 大藤剛宏, 青江基, 佐野由文

    岡山医学会雑誌   119 ( 2 )   107 - 112   2007.9

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  • Bilateral native lung-sparing lobar transplantation in a canine model Reviewed International journal

    Seiichiro Sugimoto, Hiroshi Date, Ryujiro Sugimoto, Motoi Aoe, Yoshifumi Sano

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY   132 ( 5 )   1213 - 1218   2006.11

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    Objective: Bilateral living-donor lobar lung transplantation has become an accepted approach in response to the cadaveric lung donor shortage. Because only one lobe is implanted in each chest cavity, this procedure is usually confined to patients of small size. The purpose of this study was to develop a technique of bilateral native lung - sparing lobar transplantation that can be applied to large adult patients.
    Methods: Bilateral native lung - sparing lobar transplantation was performed in 12 pairs of dogs. In donor animals the right middle, lower, and cardiac lobes were separated as a right graft, and the left lower lobe was separated as a left graft. In recipient animals these 2 grafts were implanted in the natural anatomic position with sparing native right upper, left upper, and middle lobes. In an acute study (n = 6), transplanted graft function was assessed for 3 hours after ligation of the pulmonary artery branches to the native spared lobes. In a chronic study (n = 6) the immunosuppressed recipients were observed for 3 weeks to assess the quality of bronchial healing and long-term pulmonary function.
    Results: Morphologic adaptation of the 2 grafts was found to be excellent. All 6 animals in the acute study showed excellent pulmonary function. Five of 6 animals in the chronic study survived for 3 weeks, with excellent pulmonary function and satisfactory bronchial healing.
    Conclusion: Bilateral native lung - sparing lobar transplantation was technically possible and associated with excellent pulmonary function and good bronchial healing in a canine experimental model.

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  • Post-mortem administration of urokinase in canine lung transplantation from non-heart-beating donors Reviewed International journal

    Ryujiro Sugimoto, Hiroshi Date, Seiichiro Sugimoto, Mikio Okazaki, Keiju Aokage, Hidetoshi Inokawa, Motoi Aoe, Yoshifumi Sano

    JOURNAL OF HEART AND LUNG TRANSPLANTATION   25 ( 9 )   1148 - 1153   2006.9

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    Background: We previously reported that post-mortem heparinization by closed-chest cardiac massage within 30 minutes after cardiac arrest is beneficial in lung transplantation (LTx) from non-heart-beating donors (NHBDs) by preventing formation of microthrombi. In this study, we evaluated the effects of post-mortem administration of urokinase 60 minutes after cardiac arrest.
    Methods: Left LTx was performed in 12 pairs of mongrel dogs. Donors were sacrificed and left at room temperature for 2 hours. In Group I (n = 6), heparin sodium (1,000 U/kg) was administered intravenously 60 minutes after cardiac arrest, then closed-chest cardiac massage was performed for 1 minute to distribute the heparin. In Group 2 (n = 6), the donors were treated as in Group 1, except, in addition to heparin sodium, urokinase (120,000 U) was administered intravenously before and at the end of cardiac massage. After 2 hours of cardiac arrest, donor lungs were flushed with low-potassium dextran glucose solution. After left LTx, the right pulmonary artery was ligated, and recipients were followed up for 3 hours. Uni- and multivariate repeat analyses were performed to obtain statistical data.
    Results: Group 2 had significantly better arterial oxygen tension, lower pulmonary vascular resistance and lower wet/dry weight ratio of the transplanted lung than Group 1. D-dimer level during the warm ischemia was significantly lower in Group 2 than in Group 1.
    Conclusions: Post-mortem administration of urokinase along with heparin is beneficial in LTx from NHBDs by fibrinolytic action on already formed pulmonary microthrombi in the cadaver donor lungs.

    DOI: 10.1016/j.healun.2006.07.005

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  • Intraatrial extension of thyroid cancer: A case report Reviewed

    S Sugimoto, H Doihara, Y Ogasawara, M Aoe, S Sano, N Shimizu

    ACTA MEDICA OKAYAMA   60 ( 2 )   135 - 140   2006.4

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    A 61-year-old man, who was diagnosed with superior vena cava syndrome by papillary thyroid carcinoma, was referred to our hospital. A bulky thyroid tumor with tracheal invasion extended from the left neck to the right atrium without distant metastases. The risk of sudden death due to airway occlusion, tumor embolism or obstruction of the tricuspid valve led us to elect surgery. Extended resection of thyroid cancer was performed with cardiopulmonary bypass. Peritoneal dissemination was found via laparotomy. A histologrical diagnosis of anaplastic carcinoma arising from transformation of papillary carcinoma was made. After the operation, bilateral ureteral occlusion by peritoneal dissemination and multiple lung metastases were detected. The patient died with acute renal failure on postoperative day 12. Intraatrial extension of thyroid cancer is rare, and only 12 cases have been reported in the literature. We present a case of thyroid cancer with intruatrial extension.

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  • A CASE OF INTRAPERITONEAL HEMORRHAGE FROM RUPTURED PANCREATIC PSEUDOCYST

    杉本誠一郎, 村上正和, 太田徹哉, 市原周治, 内藤稔, 清水信義

    日本臨床外科学会雑誌   66 ( 12 )   3053 - 3057   2005.12

  • Thoracoscopic operation with local and epidural anesthesia in the treatment of pneumothorax after lung transplantation Reviewed International journal

    S Sugimoto, H Date, R Sugimoto, M Okazaki, M Aoe, Y Sano, N Shimizu

    JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY   130 ( 4 )   1219 - 1220   2005.10

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    DOI: 10.1016/j.jtcvs.2005.06.019

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  • Liver Metastasis from Breast Cancer in a Long-term Survivor Treated for Lymph Node and Bone Metastasis: A Case Report

    杉本誠一郎, 土井原博義, 小笠原豊, 清水信義, 浜崎周次

    乳癌の臨床   19 ( 5 )   501 - 504   2004.10

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  • A case of rib metastasis from thyroid papillary cancer diagnosed by chest wall resection

    杉本誠一郎, 永広格, 青江基, 清水信義

    日本呼吸器外科学会雑誌   18 ( 6 )   751 - 754   2004.9

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    A 74-year-old man, who had been operated on for benign thyroid tumor 16 years earlier, was referred to our hospital for further investigation and treatment of a mass shadow noted on chest X-ray in March, 2003. Chest X-ray revealed a mass shadow of the left middle lung field and osteolytic change in the left 6th rib. Chest CT scan showed a tumor of the left 6th rib. Metastatic adenocarcinoma was suspected by CT guided needle biopsy, however, we could not find the original cancer by systemic examinations. Chest wall resection and reconstruction were performed under a diagnosis of left 6th rib tumor. The pathological diagnosis was rib metastasis of thyroid papillary cancer, follicular type. The postoperative course was uneventful and he was discharged on the 18th postoperative day. It is important to follow this patient closely because total thyroidectomy and radioiodine therapy were not performed. We have to remember the possibility of rib metastasis from thyroid cancer in diagnosis of chest wall tumor like this.

    DOI: 10.2995/jacsurg.18.6_751

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  • Endoscopic closure of bronchopleural fistula after lobectomy for lung cancer by submucosal injection of fibrin glue; -A case report

    徳毛誠樹, 永広格, 杉本誠一郎, 田尾裕之, 源寛二, 清水信義

    日本呼吸器外科学会雑誌   18 ( 6 )   716 - 720   2004.9

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    A 76-year-old man underwent right upper lobectomy for primary lung cancer, and he developed right empyema, bilateral pneumonia and respiratory insufficiency postoperatively. Artificial ventilation was necessary to maintain his respiratory condition. On the 28th postoperative day, air leakage was noted and a bronchoscopic examination revieled a bronchopleural fistula of the bronchial stump.rWe injected fibrin glue into the submucosal layer around the fistula for 5 times and finally the fistula closed two weeks after the first injection.

    DOI: 10.2995/jacsurg.18.6_716

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  • Three Cases of Bronchiolitis Obliterans Organizing Pneumonia Syndrome after Breast-Conserving Therapy

    杉本誠一郎, 土井原博義, 高橋寛敏, 小笠原豊, 清水信義

    乳癌の臨床   19 ( 4 )   385 - 390   2004.8

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  • Mediastinal cyst with rim calcification Reviewed

    Seiichiro Sugimoto, Takahiko Misao, Hideharu Nakano, Masataka Yamane

    Japanese Journal of Thoracic and Cardiovascular Surgery   52 ( 5 )   261 - 263   2004

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    A 58-year-old man who had been undergoing treatment for chronic pericarditis for 15 months was found to have a calcified mediastinal mass shadow on a chest X-ray and was referred to us for further study and treatment. Chest computed tomography and magnetic resonance imaging showed an anterior mediastinal multilocular tumor with rim calcification. Tumor markers were within normal limits. The patient was preoperatively diagnosed as having a calcified mediastinal cyst, and median sternotomy was performed to remove the cystic tumor and the surrounding thymic tissues. Histological examination revealed that the cyst wall consisted of dense fibrous tissue and calcification without epithelial cell lining on the inner surface. Thymic tissue was present around the cyst wall. Although we suspected a thymic cyst from the intraoperative findings, the final diagnosis was made as mediastinal cyst with rim calcification. We herein present a rare case of mediastinal cyst with rim calcification.

    DOI: 10.1007/s11748-004-0121-0

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  • A CASE OF BILATERAL OBTURATOR HERNIA PREOPERATIVELY DIAGNOSED BY COMPUTED TOMOGRAPHY.

    杉本誠一郎, 萱野公一, 宮崎医津博, 西岡聖

    日本臨床外科学会雑誌   64 ( 9 )   2327 - 2332   2003.9

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    A 59-year-old woman admitted for lower abdominal pain and vomiting had tenderness, Blumberg's sign, and muscular defense throughout the lower abdomen, but no Howship-Romberg's sign. Abdominal computed tomography (CT) showed ascites, dilation of the small intestine, and bilateral obturator hernia. An emergency laparotomy was conducted based on a diagnosis of perforated peritonitis due to incarcerated bilateral obturator hernia. At laparotomy, the jejunum 80 cm from Treitz's ligament was incarcerated into the right obturator foramen and perforated. The jejunum of left obturator hernia was easily released without perforation. After wedge jejunal resection, the bilateral hernia hilum was closed with direct sutures and covered with the ovary. The postoperative course was good and she was discharged on postoperative day 24.<br>The number of cases of obturator hernia diagnosed preoperatively has increased in Japan, but bilateral obturator hernia is rare and has been reported in 51 cases including this case in a review of the Japanese literature.

    DOI: 10.3919/jjsa.64.2327

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  • A CASE OF PERFORATED ANASTOMOTIC ULCER TREATED BY OMENTAL IMPLANTATION

    杉本誠一郎, 萱野公一, 宮崎医津博, 西岡聖

    日本臨床外科学会雑誌   64 ( 6 )   1497 - 1501   2003.6

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    A case of perforated anastomotic ulcer, which is rare recently, was successfully treated by omental implantation.<br>A 40-year-old man, who had undergone a distal partial gastrectomy with Billroth II reconstruction for perforated duodenal ulcer at the age of 18, was seen at the hospital because of tenderness and muscular defense throughout the upper abdomen. The white blood cell count was 13, 190/mm3, CRP was 0.01mg/dl, and gastrin level was low. Chest and abdominal X-ray films revealed free air in the subphrenic space. An abdominal CT scan showed intraperitoneal free air around the remnant stomach and gastrojejunostomy. An emergency laparotomy was performed with a diagnosis of panperitonitis. During surgery, a perforated ulcer at the anastomotic site, which was reconstructed by antecolic Billroth II procedure and Braun anastomosis, was comfirmed and then peritoneal drainage and omental implantation were carried out. A proton pump inhibitor was given to the patient after the operation. The postoperative course was good and he was discharged on the 20th postoperative day. Omental implantation is useful for perforated anastomotic ulcer and is able to become one choice for emergency surgery. But this method is not a radical operation and there is a possibility of recurrence. It is important to follow the patient as long as possible keeping possible reoperation in mind.

    DOI: 10.3919/jjsa.64.1497

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  • A Case of Idiopathic Small Bowel Perforation.

    杉本誠一郎, 萱野公一, 宮崎医津博, 西岡聖, 内田発三

    日本臨床外科学会雑誌   64 ( 1 )   107 - 110   2003.1

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    Atraumatic small bowel perforations are relatively rare and their causes are monifold. We experienced and reported a rare case of idiopathic small bowel perforation.<br>An 84-year-old man, who was performed a pancreaticoduodenectomy for gall bladder cancer at 82 years old, had tenderness and peritoneal signs throughout the abdomen. Chest and abdominal X-ray films did not reveal free gas and ileus. An abdominal CT scan showed intraperitoneal free air. An emergency laparotomy was performed with a diagnosis of panperitonitis. At the laparotomy, the perforation was comfirmed at the ileum locating 65cm from Bauhin's valve and a partial ileal resection was carried out. There were no signs of metastasis, recurrence, intraperitoneal adhesion or ileus. Histologically, mucosa, muscle and serosa layer were completely cleft and mucosa layer was not slided into serosal side, and malignant and chronic inflammatory lesions were not seen. The cause of perforation was not specified from any findings and he was definitely diagnosed as idiopathic small bowel perforation. The postoperative course of the patient was good, but he died of another disease on postoperative day 76th.

    DOI: 10.3919/jjsa.64.107

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  • A case of combined large cell neuroendocrine carcinoma (LCNEC) and squamous cell carcinoma.

    杉本誠一郎, 水谷尚雄, 萱野公一, 寺本滋

    日本呼吸器外科学会雑誌   16 ( 4 )   559 - 564   2002.5

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    A 52-year-old man was referred to our hospital for further investigation and treatment of a tumor shadow noted on chest X-ray in January, 2000. The chest CT scan showed a large tumor shadow in the right upper lobe. Tumor markers (keratin, SLX, CYFRA and NSE) were elevated. On January 25, right upper lobectomy with regional lymph node dissection and partial resection of the third rib were performed . Pathological diagnosis was combined large cell neuroendocrine carcinoma (LCNEC) and squamous cell carcinoma, and histological staging grade was II B (T3N0M0). The postoperative course of the patient was good, but he had a local recurrence 10 months after discharge and then died.

    DOI: 10.2995/jacsurg.16.4_559

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  • 再発・切除を繰り返した右胸壁原発spindle cell sarcomaの1例

    杉本誠一郎, 萱野公一, 岩浅祐二郎, 水谷尚雄, 古城資久, 宮崎医津博, 長尾俊彦, 西岡聖, 内田発三

    兵庫県全外科医会会誌   38 ( 1 )   24 - 26   2002.3

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  • 肺原発large cell neuroendocrine carcinomaの1例

    杉本誠一郎, 中野秀治, 神野禎次, 多胡護, 山根正隆, 三竿貴彦

    香川県立中央病院医学雑誌   20   45 - 48   2001.3

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  • 原発不明肺門リンパ節小細胞がんの1切除例

    守安江 梨伽, 諏澤 憲, 柳光 剛志, 田中 真, 橋本 好平, 枝園 和彦, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    肺癌   63 ( 7 )   1007 - 1008   2023.12

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  • 扁平上皮癌転化を来したEGFR変異肺腺癌に対してサルベージ手術を施行した1例

    藤井 龍之介, 諏澤 憲, 柳光 剛志, 田中 真, 橋本 好平, 枝園 和彦, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一, 槇本 剛

    肺癌   63 ( 7 )   1005 - 1005   2023.12

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  • EP07.01-12 A Retrospective Study on the Methods of Covering Bronchial Stump/Anastomotic Site to Avoid the Bronchopleural Fistula after Lung Cancer Surgery

    T. Habu, H. Yamamoto, K. Nakata, K. Hashimoto, S. Tanaka, K. Suzawa, K. Shien, K. Miyoshi, M. Okazaki, S. Sugimoto, S. Toyooka

    Journal of Thoracic Oncology   18 ( 11 )   S512 - S513   2023.11

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    DOI: 10.1016/j.jtho.2023.09.958

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  • ショットガンメタゲノム解析を用いた難治性 肺がんマイクロバイオームの解明

    松岡篤志, 枝園和彦, 大亀正義, 冨田秀太, 田中真, 橋本好平, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 遠西大輔, 豊岡伸一

    第64回日本肺癌学会学術集会   2023.11

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  • 空間マルチオミクス解析を駆使した肺がんドライ バー遺伝子異常と微小環境との相互作用の解明

    枝園和彦, 大亀正義, 冨田秀太, 松岡篤志, 吉川真生, 諏澤憲, 山本寛斉, 岡崎幹生, 杉本誠一郎, 遠西大輔, 豊岡伸一

    第64回日本肺癌学会学術集会   2023.11

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  • 胸腺癌における腫瘍浸潤リンパ球・三次リンパ組織様構 造・末梢血好中球/リンパ球比と術後予後に関する検討

    土生智大, 山本寛斉, 橋本好平, 田中真, 諏澤憲, 枝園和彦, 三好健太郎, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    第64回日本肺癌学会学術集会   2023.11

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  • ライフイベント時に本当に必要な支 援とは?高いチーム力でダイバーシ ティとインクルージョンを目指す当 院のキャリア支援

    小林純子, 竹原裕子, 溝尾妙子, 菊地覚次, 三好健太郎, 黒田新士, 田邊, 俊介, 楳田祐三, 小谷恭弘, 杉本誠一郎, 岡崎幹生, 枝園忠彦, 豊岡伸, 一, 藤原俊義, 笠原真悟

    第85回日本臨床外科学会総会   2023.11

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  • 術中迅速による肺門リンパ節転移陰性確認に基 づく縦隔リンパ節郭清の省略は許容されるのか

    諏澤憲, 橋本好平, 田中真, 枝園和彦, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    第64回日本肺癌学会学術集会   2023.11

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  • 肺炎症性筋線維芽細胞腫瘍の3 切除例

    梅田将志, 三好健太郎, 田中真, 橋本好平, 諏澤憲, 枝園和彦, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    第64回日本肺癌学会学術集会   2023.11

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  • 中葉気管支より分岐する右B2 およびB3 転 位気管支を伴う肺癌に対する2 切除例

    今西謙太郎, 諏澤憲, 柳光剛志, 調枝治樹, 橋本好平, 田中真, 枝園和彦, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    第64回日本肺癌学会学術集会   2023.11

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  • Risk factors and short- and long-term outcomes after deceased donor lung transplantation – single center cohort study from Okayama University

    Haruki Choshi, Kentaroh Miyoshi, Masashi Umeda, Tsuyoshi Ryuko, Hiroyuki Ujike, Shinichi Kawana, Yujiro Kubo, Shin Tanaka, Kohei Hashimoto, Mikio Okazaki, Seiichiro Sugimoto, Shinichi Toyooka

    Lung Transplantation Conference 2023   2023.11

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  • 肺癌手術の治療成績にフレイルティが与える影響

    杉本誠一郎, 松原慧, 調枝治樹, 田中真, 橋本好平, 諏澤憲, 枝園和彦, 三好健太郎, 山本寛斉, 岡崎幹生, 豊岡伸一

    第76回日本胸部外科学会定期学術集会   2023.10

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    杉本誠一郎

    Transplant Day 2023   2023.10

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  • 岡山大学脳死肺移植例におけるドナー因子と短・長期アウトカム

    三好健太郎, 田中真, 杉本誠一郎, 調枝治樹, 松原慧, 富岡泰章, 塩谷俊雄, 橋本好平, 黒崎毅史, 大谷真二, 岡﨑幹夫, 山根正修, 豊岡伸一

    第76回日本胸部外科学会定期学術集会   2023.10

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  • 術中トラブルシューティングや肺動脈形成の経験から考察したRATS の適応

    岡崎幹生, 田中真, 橋本好平, 枝園和彦, 諏澤憲, 三好健太郎, 山本寛斉, 杉本誠一郎, 豊岡伸一

    第76回日本胸部外科学会定期学術集会   2023.10

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  • Miracle Recovery Case 肺移植待機中の重度の心原性ショックに対してECMO+IMPELLAによる循環補助で救命し、回復期に肺移植を施行した症例

    田中 真, 石上 恵美, 石原 恵, 調枝 治樹, 橋本 好平, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斎, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    移植   58 ( 総会臨時 )   135 - 135   2023.9

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  • Pushing the Border!攻めの肺移植 DQ-DSA陽性生体肺移植レシピエントに対する両側脳死再肺移植

    三好 健太郎, 調枝 治樹, 富岡 泰章, 石原 恵, 田中 真, 杉本 誠一郎, 山根 正修, 久保 友次郎, 川名 伸一, 清水 大, 松原 慧, 橋本 好平, 岡崎 幹生, 豊岡 伸一

    移植   58 ( 総会臨時 )   148 - 148   2023.9

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  • 新型コロナ時代の肺移植 肺移植患者におけるCOVID-19の発症抑制を目的とした中和抗体薬の投与

    川名 伸一, 杉本 誠一郎, 調枝 治樹, 田中 真, 石原 恵, 橋本 好平, 諏澤 憲, 枝園 和彦, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 豊岡 伸一

    移植   58 ( 総会臨時 )   193 - 193   2023.9

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  • 生体肺移植後の慢性腎臓病に対して生体腎移植を施行した2例

    柳光 剛志, 杉本 誠一郎, 調枝 治樹, 田中 真, 橋本 好平, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 石原 恵, 豊岡 伸一

    移植   58 ( 総会臨時 )   298 - 298   2023.9

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  • 腹膜透析による横隔膜交通症に対して術中ICG を用いて横隔膜縫縮 術を施行した一例

    林 直宏, 橋本好平, 調枝治樹, 田中 真, 枝園和彦, 諏澤 憲, 三好健太郎, 山本寛斉, 岡﨑幹生, 杉本誠一郎, 豊岡伸一

    第98回中国四国外科学会総会   2023.9

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  • 肺底動脈大動脈起始症に対する胸腔鏡下左肺底区域切除術の2症例

    林 龍也, 三好健太郎, 調枝治樹, 今西謙太郎, 三原大樹, 石村昴誠, 藤井龍之介, 橋本好平, 田中 真, 諏澤 憲, 枝園和彦, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    第98回中国四国外科学会総会   2023.9

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  • MRSA 肺炎を合併し治療に難渋した先天性気管支閉鎖症の1 切除例

    三原大樹, 田中 真, 枝園和彦, 山本寛斉, 石村昂誠, 今西謙太郎, 林 龍也, 藤井龍之介, 橋本好平, 諏澤 憲, 三好健太郎, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    第98回中国四国外科学会総会   2023.9

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  • 肺移植レシピエントにおけるSARS-CoV-2ワクチン追加接種の有効性の検討

    川名 伸一, 杉本誠一郎, 調枝 治樹, 田中 真, 三好健太郎, 梅田 将志, 柳光 剛志, 氏家 裕征, 久保友次郎, 橋本 好平, 諏澤 憲, 枝園 和彦, 山本 寛斉, 岡﨑 幹生, 豊岡 伸一

    第68回日本呼吸器学会 中国・四国地方会   2023.7

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  • 臓器移植法改正後の肺移植の変遷

    今村 由人, 中島 大輔, 狩野 孝, 新谷 康, 杉本 誠一郎, 豊岡 伸一, 星川 康, 松本 桂太郎, 永安 武, 鈴木 秀海, 吉野 一郎, 前田 寿美子, 千田 雅之, 白石 武史, 佐藤 寿彦, 佐藤 雅昭, 中島 淳, 大石 久, 岡田 克典, 伊達 洋至

    日本呼吸器外科学会雑誌   37 ( 3 )   O17 - 1   2023.6

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  • 椎体浸潤を伴う非小細胞肺癌に対する術前導入化学放射線療法後手術症例の治療成績の検討

    林 直宏, 山本 寛斉, 橋本 好平, 田中 真, 枝園 和彦, 諏澤 憲, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    日本呼吸器外科学会雑誌   37 ( 3 )   O8 - 2   2023.6

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  • 慢性移植肺機能不全(CLAD)に対する再肺移植の術式と長期成績

    杉本 誠一郎, 調枝 治樹, 氏家 裕征, 川名 伸一, 久保 友次郎, 松原 慧, 田中 真, 橋本 好平, 諏澤 憲, 枝園 和彦, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 豊岡 伸一

    日本呼吸器外科学会雑誌   37 ( 3 )   O18 - 4   2023.6

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  • 67歳の間質性肺炎に対する両側生体肺移植の経験

    調枝 治樹, 杉本 誠一郎, 田中 真, 氏家 裕征, 松原 慧, 橋本 好平, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 豊岡 伸一

    日本呼吸器外科学会雑誌   37 ( 3 )   O18 - 2   2023.6

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    J-GLOBAL

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  • 肺移植レシピエントにおけるSARS-CoV-2ワクチン追加接種の有効性の検討

    川名 伸一, 杉本 誠一郎, 松原 慧, 田中 真, 三好 健太郎, 調枝 治樹, 氏家 裕征, 久保 友次郎, 清水 大, 橋本 好平, 枝園 和彦, 諏澤 憲, 山本 寛斉, 岡崎 幹生, 豊岡 伸一

    日本呼吸器外科学会雑誌   37 ( 3 )   O17 - 2   2023.6

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  • 肺虚血再灌流障害に対する高ヒスチジン糖タンパク質(HRG)補充療法の有用性

    久保 友次郎, 杉本 誠一郎, 調枝 治樹, 氏家 裕征, 川名 伸一, 清水 大, 松原 慧, 橋本 好平, 田中 真, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 豊岡 伸一

    日本呼吸器外科学会雑誌   37 ( 3 )   O19 - 2   2023.6

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  • 多発肋骨骨折に対する金属ワイヤ固定の工夫 Twisted wire splint法

    柳光 剛志, 三好 健太郎, 松原 慧, 橋本 好平, 田中 真, 枝園 和彦, 諏澤 憲, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    日本呼吸器外科学会雑誌   37 ( 3 )   P30 - 3   2023.6

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  • 術後46年で胸膜播種再発をきたした無巨核球性血小板減少を伴う赤芽球癆と重症筋無力症合併胸腺腫の一切除例

    梅田 将志, 諏澤 憲, 田中 真, 橋本 好平, 枝園 和彦, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    日本呼吸器外科学会雑誌   37 ( 3 )   P69 - 3   2023.6

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  • 子宮肉腫肺転移における腫瘍浸潤リンパ球・三次リンパ様構造・末梢血好中球リンパ球比の検討

    山本 寛斉, 松田 直樹, 橋本 好平, 田中 真, 枝園 和彦, 諏澤 憲, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    日本呼吸器外科学会雑誌   37 ( 3 )   O14 - 7   2023.6

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  • 多様な体幹部巨大軟部肉腫の切除における胸壁再建の工夫

    梅田将志, 三好健太郎, 田中 真, 橋本好平, 諏澤 憲, 枝園和彦, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    第66回関西胸部外科学会学術集会   2023.6

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  • Long-term outcome of cadaveric and living-donor lobar lung transplantation

    Seiichiro Sugimoto

    International Symposium on Lung Transplantation   2023.6

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  • ロボット支援下肺切除手術における術中トラブルシューティング

    諏澤 憲, 田中 真, 橋本好平, 枝園和彦, 三好健太郎, 山本寛斉, 岡﨑幹生, 杉本誠一郎, 豊岡伸一

    第66回関西胸部外科学会学術集会   2023.6

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  • 肺移植における気管支吻合: スペイン仕込みのこだわり吻合

    田中 真, 調枝治樹, 橋本好平, 枝園和彦, 諏澤 憲, 三好健太郎, 山本寛斉, 岡﨑幹生, 杉本誠一郎, 豊岡伸一

    第66回関西胸部外科学会学術集会   2023.6

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  • 縦隔セミノーマに対するサルベージ手術

    橋本好平, 諏澤 憲, 調枝治樹, 田中 真, 枝園和彦, 三好健太郎, 山本寛斉, 岡﨑幹生, 杉本誠一郎, 豊岡伸一

    第66回関西胸部外科学会学術集会   2023.6

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  • 術後46年で胸膜播種再発をきたした無巨核球性血小板減少を伴う赤芽球癆と重症筋無力症合併胸腺腫の一切除例

    梅田 将志, 諏澤 憲, 田中 真, 橋本 好平, 枝園 和彦, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    日本呼吸器外科学会雑誌   37 ( 3 )   P69 - 3   2023.6

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  • 多発肋骨骨折に対する金属ワイヤ固定の工夫 Twisted wire splint法

    柳光 剛志, 三好 健太郎, 松原 慧, 橋本 好平, 田中 真, 枝園 和彦, 諏澤 憲, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    日本呼吸器外科学会雑誌   37 ( 3 )   P30 - 3   2023.6

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  • 臓器移植法改正後の肺移植の変遷

    今村 由人, 中島 大輔, 狩野 孝, 新谷 康, 杉本 誠一郎, 豊岡 伸一, 星川 康, 松本 桂太郎, 永安 武, 鈴木 秀海, 吉野 一郎, 前田 寿美子, 千田 雅之, 白石 武史, 佐藤 寿彦, 佐藤 雅昭, 中島 淳, 大石 久, 岡田 克典, 伊達 洋至

    日本呼吸器外科学会雑誌   37 ( 3 )   O17 - 1   2023.6

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  • 肺移植術前の骨格筋量および待機期間中の骨格筋量変化と術後アウトカムの関連について

    萩山 明和, 杉本 誠一郎, 田中 真, 松原 慧, 三好 健太郎, 堅山 佳美, 濱田 全紀, 千田 益生, 豊岡 伸一

    移植   57 ( 4 )   402 - 402   2023.4

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  • 脳死両肺移植後患者における血栓性微小血管障害症(Thorombotic microangiopathy:TMA)

    柳光 剛志, 三好 健太郎, 松原 慧, 橋本 好平, 田中 真, 枝園 和彦, 諏澤 憲, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    移植   57 ( 4 )   415 - 415   2023.4

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  • 非小細胞肺がんにおける腫瘍免疫状態指標としての好中球・リンパ球比(NLR)の有用性

    岩田 一馬, 諏澤 憲, 松原 慧, 橋本 好平, 田中 真, 枝園 和彦, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    日本外科学会定期学術集会抄録集   123回   DP - 2   2023.4

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  • 外科専攻医の産育休後復帰支援とダイバーシティ推進のための全体教育への取り組み

    竹原 裕子, 溝尾 妙子, 小林 純子, 安井 和也, 菊池 覚次, 黒田 新士, 楳田 祐三, 吉田 龍一, 小谷 恭弘, 杉本 誠一郎, 岡崎 幹生, 枝國 忠彦, 豊岡 伸一, 笠原 真悟

    日本外科学会定期学術集会抄録集   123回   SF - 4   2023.4

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  • 待機中に二次性肺高血圧を発症した特発性肺線維症に対する脳死左片肺移植術

    調枝 治樹, 三好 健太郎, 清水 大, 松原 慧, 橋本 好平, 田中 真, 枝園 和彦, 諏澤 憲, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    移植   57 ( 4 )   394 - 394   2023.4

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  • (347) Augmented Humoral Response to a Third And Fourth Dose of Mrna Sars-Cov-2 Vaccines in Lung Transplant Recipients

    S. Kawana, S. Sugimoto, K. Matsubara, S. Tanaka, K. Miyoshi, H. Choshi, H. Ujike, Y. Kubo, D. Shimizu, K. Hashimoto, K. Shien, K. Suzawa, H. Yamamoto, M. Okazaki, S. Toyooka

    The Journal of Heart and Lung Transplantation   42 ( 4 )   S164 - S165   2023.4

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    DOI: 10.1016/j.healun.2023.02.1651

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  • (875) A Novel Strategy In Vivo Lung Recovery for Prompt Recovery from Primary Graft Dysfunction after Lung Transplantation

    K. Matsubara, K. Miyoshi, K. Takeshi, S. Kawana, Y. Kubo, D. Shimizu, K. Hashimoto, S. Tanaka, M. Okazaki, S. Sugimoto, S. Toyooka

    The Journal of Heart and Lung Transplantation   42 ( 4 )   2023.4

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    DOI: 10.1016/j.healun.2023.02.888

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  • (891) Bilateral Lung Transplantation from Living Donors in a 67-Year-Old Patient

    H. Ujike, S. Tanaka, H. Choshi, S. Kawana, Y. Kubo, D. Shimizu, K. Matsubara, K. Hashimoto, K. Shien, K. Suzawa, K. Miyoshi, H. Yamamoto, M. Okazaki, S. Sugimoto, S. Toyooka

    The Journal of Heart and Lung Transplantation   42 ( 4 )   2023.4

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    DOI: 10.1016/j.healun.2023.02.904

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  • (258) Histidine-Rich Glycoprotein Ameliorates Lung Ischemia-Reperfusion Injury in a Mouse

    Y. Kubo, S. Sugimoto, H. Choshi, H. Ujike, S. Kawana, D. Shimizu, K. Matsubara, K. Hashimoto, S. Tanaka, K. Shien, K. Suzawa, K. Miyoshi, H. Yamamoto, M. Okazaki, S. Toyooka

    The Journal of Heart and Lung Transplantation   42 ( 4 )   S124 - S125   2023.4

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    DOI: 10.1016/j.healun.2023.02.1562

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  • (78) Indication and Long-Term Outcome of Pediatric Lung Transplantation in Japan; A Multicenter, Retrospective Study

    Y. Morimura, S. Tanaka, K. Matsubara, S. Tanaka, T. Kanou, Y. Yamada, Y. Yutaka, A. Ohsumi, D. Nakajima, M. Hamaji, Y. Shintani, S. Sugimoto, S. Toyooka, H. Date

    The Journal of Heart and Lung Transplantation   42 ( 4 )   S44 - S45   2023.4

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    DOI: 10.1016/j.healun.2023.02.094

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  • (1068) Successful Lung Re-Transplantation with Perioperative Desensitization for Sensitized Recipient with Donor Specific DQ Antibody

    H. Choshi, K. Miyoshi, H. Ujike, S. Kawana, Y. Kubo, D. Shimizu, K. Matsubara, K. Hashimoto, S. Tanaka, K. Shien, K. Suzawa, H. Yamamoto, M. Okazaki, S. Sugimoto, S. Toyooka

    The Journal of Heart and Lung Transplantation   42 ( 4 )   S461 - S462   2023.4

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    DOI: 10.1016/j.healun.2023.02.1279

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  • 広範な心嚢内大血管浸潤を伴う局所進行肺がんに対して集学的治療が奏効した1例

    松岡 篤志, 諏澤 憲, 吉川 真生, 田中 真, 橋本 好平, 枝園 和彦, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    肺癌   63 ( 1 )   74 - 74   2023.2

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  • 肺移植術前の骨格筋量と質、およびその待機期間中の変化と術後アウトカムの関連性

    萩山 明和, 杉本 誠一郎, 三好 健太郎, 田中 真, 松原 慧, 堅山 佳美, 濱田 全紀, 千田 益生, 豊岡 伸一

    呼吸理学療法学   3 ( Suppl. )   138 - 138   2023

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  • Downsizing Cadaveric Lung Transplantation

    SUGIMOTO Seiichiro, CHOSHI Haruki, TANAKA Shin, ISHIHARA Megumi, HASHIMOTO Kohei, SUZAWA Ken, SHIEN Kazuhiko, MIYOSHI Kentaroh, YAMAMOTO Hiromasa, OKAZAKI Mikio, TOYOOKA Shinichi

    日本移植学会総会プログラム抄録集   59th (Web)   2023

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  • 導入化学放射線療法後に再発を認めた非小細胞肺がん症例に対する局所治療の意義

    枝園和彦, 吉川真生, 大亀正義, 橋本好平, 田中真, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 木浦勝行, 豊岡伸一

    肺癌   62 ( 6 )   532 - 532   2022.12

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  • 術前画像によるTis/T1 肺腺癌の予後予測モデル

    吉川真生, 枝園和彦, 松原慧, 田中真, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    肺癌   62 ( 6 )   711 - 711   2022.12

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  • 局所進行肺癌に対する集学的治療における末梢血好中球/リンパ球比(NLR)と放射線肺臓炎の関連

    久保友次郎, 山本寛斉, 松原慧, 橋本好平, 田中真, 枝園和彦, 諏澤憲, 三好健太郎, 岡崎幹生, 杉本誠一郎, 勝井邦彰, 平木隆夫, 豊岡伸一

    肺癌   62 ( 6 )   704 - 704   2022.12

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  • 子宮肉腫肺転移における腫瘍浸潤リンパ球,三次リンパ様構造,末梢血好中球リンパ球比・総リンパ球数の検討

    山本寛斉, 松田直樹, 橋本好平, 田中真, 枝園和彦, 諏澤憲, 三好健太郎, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    肺癌   62 ( 6 )   622 - 622   2022.12

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  • 肺移植の実際とリハビリテーション医療 Invited

    杉本誠一郎

    第6回日本リハビリテーション医学会秋季学術集会プログラム・抄録集   S158 - S158   2022.11

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  • Pulmonary Alveolar Proteinosis after Lung Transplantation

    Dai Shimizu, Shinichi Kawana, Kentaroh Miyoshi, Shin Tanaka, Yujiro Kubo, Kei Matsubara, Kohei Hashimoto, Mikio Okazaki, Seiichiro Sugimoto, Shinichi Toyooka

    The 17th Lung Transplantation Conference   2022.10

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  • 臓器保存の最前線 Ex vivo lung perfusion技術を体内へ応用したIn vivo Lung Recoveryによる新規治療戦略

    松原 慧, 三好 健太郎, 黒崎 毅史, 川名 伸一, 久保 友次郎, 清水 大, 橋本 好平, 田中 真, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    移植   57 ( 総会臨時 )   182 - 182   2022.10

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  • 肺グラフト評価法と保存法の現状と展望 心停止ドナー肺移植におけるEx Vivo Lung Perfusionの展望

    田中 真, 石上 恵美, 石原 恵, 松原 慧, 橋本 好平, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    移植   57 ( 総会臨時 )   211 - 211   2022.10

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  • 日本での心停止ドナー肺移植導入に向けて、スペインでの経験を踏まえて

    田中 真, 石上 恵美, 石原 恵, 橋本 好平, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹夫, 杉本 誠一郎, 豊岡 伸一

    移植   57 ( 総会臨時 )   338 - 338   2022.10

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  • 肺移植後長期予後向上への取り組み 60歳以上の高齢肺移植レシピエントにおける傾向スコアマッチングを用いた術後長期成績に関する検討

    久保 友次郎, 田中 真, 氏家 裕征, 川名 伸一, 清水 大, 松原 慧, 富岡 泰章, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    移植   57 ( 総会臨時 )   224 - 224   2022.10

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  • 生体肺移植のオプションがない再肺移植待機中の男児に対して長期的な肺移植までのブリッジとしての使用も視野に入れたV-V ECMOの導入経験

    富岡 泰章, 三好 健太郎, 田中 真, 杉本 誠一郎, 伊賀 徳周, 金井 理恵, 二階 哲朗, 豊岡 伸一, 山根 正修

    移植   57 ( 総会臨時 )   337 - 337   2022.10

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  • 小児ドナーからの臓器摘出,小児臓器移植における留意点 小児肺移植の適応疾患と長期予後 多施設共同後ろ向き研究

    森村 祐樹, 田中 里奈, 松原 慧, 田中 真, 狩野 孝, 山田 義人, 豊 洋次郎, 大角 明宏, 中島 大輔, 濱路 政嗣, 新谷 康, 杉本 誠一郎, 豊岡 伸一, 伊達 洋至

    移植   57 ( 総会臨時 )   178 - 178   2022.10

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  • 生体ドナーの健康を考える 生体ドナーの肺移植後長期的なQOLの検討

    藤井 健人, 田中 真, 石上 恵美, 石原 恵, 松原 慧, 橋本 好平, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   57 ( 総会臨時 )   172 - 172   2022.10

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  • 中四国の非移植施設との連携による肺メディカルコンサルタント互助の取り組み

    杉本 誠一郎, 松原 慧, 清水 大, 橋本 好平, 田中 真, 三好 健太郎, 石原 恵, 富岡 泰章, 塩谷 俊雄, 鹿谷 芳伸, 山根 正修, 青江 基, 豊岡 伸一

    移植   57 ( 総会臨時 )   337 - 337   2022.10

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  • 新型コロナウイルス時代の臓器提供,臓器移植のありかた 肺移植レシピエントに発症したCOVID-19の経験

    川名 伸一, 杉本 誠一郎, 田中 真, 三好 健太郎, 氏家 裕征, 久保 友次郎, 清水 大, 松原 慧, 橋本 好平, 諏澤 憲, 枝園 和彦, 山本 寛斉, 岡崎 幹生, 豊岡 伸一

    移植   57 ( 総会臨時 )   143 - 143   2022.10

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  • SympathicotomyとRamicotomyを併施した胸部交感神経遮断術

    調枝治樹, 三好健太郎, 松原慧, 橋本好平, 田中真, 枝園和彦, 諏澤憲, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    第97回中国四国外科学会総会   O-10   2022.9

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  • 術前組織診断が肺腺癌であった細気管支腺腫/線毛性粘液結節性乳頭状腫瘍の1切除例

    中村薫, 諏澤憲, 松岡篤志, 水野大輔, 吉近諒, 調枝治樹, 橋本好平, 田中 真, 枝園和彦, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    第97回中国四国外科学会総会   Y-42   2022.9

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  • 上縦隔血管前リンパ節にsingle station転移再発を来した右下葉肺癌術後の一例

    水野大輔, 諏澤憲, 松岡篤志, 吉近諒, 調枝治樹, 松原慧, 田中 真, 橋本好平, 枝園和彦, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    第97回中国四国外科学会総会   Y-36   2022.9

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  • 肺移植up-to-date Invited

    杉本誠一郎

    第97回中国四国外科学会総会   ES1-2   2022.9

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  • 広範な心嚢内大血管浸潤を伴う局所進行肺がんに対して集学的治療が奏功した一例

    松岡篤志, 諏澤憲, 吉川真生, 田中真, 橋本好平, 枝園和彦, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    第60回日本肺癌学会 中国・四国支部学術集会   HT-24   2022.7

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  • 多発血管炎性肉芽腫症に合併した左上葉肺癌の一例

    橋本好平, 三好健太郎, 松原慧, 田中真, 枝園和彦, 諏澤憲, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    第60回日本肺癌学会 中国・四国支部学術集会   H-13   2022.7

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  • 超音波手術器を用いて胸腔鏡下に切除した肋骨腫瘍の一例

    氏家裕征, 山本寛斉, 松原慧, 田中真, 橋本好平, 諏澤憲, 枝園和彦, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    第60回日本肺癌学会 中国・四国支部学術集会   H-11   2022.7

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  • 移植登録後に急速に増悪し二次性肺高血圧症にいたった特発性肺線維症に対する脳死片肺移植

    松原慧, 三好健太郎, 氏家裕征, 川名伸一, 久保友次郎, 清水大, 橋本好平, 田中真, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    第66回日本呼吸器学会 中国・四国地方会   K-10   2022.7

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    杉本 誠一郎

    医工学治療   34 ( Suppl. )   111 - 111   2022.5

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  • ステレオタイプ・スレットという問題とニュースレターの果たす役割

    竹原 裕子, 溝尾 妙子, 小林 純子, 坂本 美咲, 新田 薫, 工藤 由里絵, 安井 和也, 菊池 覚次, 黒田 新士, 吉田 龍一, 岡崎 幹生, 杉本 誠一郎, 枝園 忠彦, 小谷 恭弘, 豊岡 伸一, 笠原 真悟, 藤原 俊義, 土井原 博義

    日本外科学会定期学術集会抄録集   122回   SP - 6   2022.4

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  • Identification of Single-Nucleotide Polymorphisms Associated with Renal Dysfunction After Lung Transplantation Using Ethnic-Specific SNP Array

    Y. Tomioka, S. Sugimoto, S. Kawana, Y. Kubo, D. Shimizu, K. Matsubara, S. Tanaka, K. Miyoshi, M. Okazaki, S. Toyooka

    The Journal of Heart and Lung Transplantation   41 ( 4 )   S254 - S255   2022.4

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    DOI: 10.1016/j.healun.2022.01.623

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  • The Percentage of Low Attenuation Area on Computed Tomography to Detect Chronic Lung Allograft Dysfunction After Bilateral Lung Transplantation

    Y. Kubo, S. Sugimoto, T. Shiotani, S. Kawana, D. Shimizu, K. Matsubara, K. Hashimoto, S. Tanaka, K. Shien, K. Suzawa, K. Miyoshi, H. Yamamoto, M. Okazaki, S. Toyooka

    The Journal of Heart and Lung Transplantation   41 ( 4 )   S106 - S107   2022.4

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    DOI: 10.1016/j.healun.2022.01.247

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  • Pulmonary Alveolar Proteinosis After Lung Transplantation

    S. Kawana, K. Miyoshi, S. Tanaka, S. Sugimoto, Y. Kubo, D. Shimizu, K. Matsubara, K. Hashimoto, K. Shien, K. Suzawa, H. Yamamoto, M. Okazaki, S. Toyooka

    The Journal of Heart and Lung Transplantation   41 ( 4 )   S378 - S379   2022.4

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    DOI: 10.1016/j.healun.2022.01.1512

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  • Inhibiting S100A8/A9 Attenuates Airway Obstruction in a Mouse Heterotopic Tracheal Transplantation Model

    D. Shimizu, M. Okazaki, S. Sugimoto, R. Kinoshita, S. Kawana, Y. Kubo, K. Matsubara, K. Nakata, A. Matsukawa, M. Sakaguchi, S. Toyooka

    The Journal of Heart and Lung Transplantation   41 ( 4 )   2022.4

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    DOI: 10.1016/j.healun.2022.01.191

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  • Anti-S100A8/A9 Neutralizing Monoclonal Antibody Ameliorates Lung Injury Induced by Lung Ischemia Reperfusion Injury

    K. Nakata, M. Okazaki, K. Miyoshi, S. Sugimoto, M. Sakaguchi, S. Toyooka

    The Journal of Heart and Lung Transplantation   41 ( 4 )   2022.4

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    DOI: 10.1016/j.healun.2022.01.040

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  • Impact of Prognostic Nutrition Index on the Waitlist Mortality of Lung Transplantation

    K. Matsubara, S. Otani, S. Kawana, Y. Kubo, D. Shimizu, S. Tanaka, K. Miyoshi, M. Okazaki, S. Sugimoto, S. Toyooka

    The Journal of Heart and Lung Transplantation   41 ( 4 )   S49 - S50   2022.4

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    DOI: 10.1016/j.healun.2022.01.112

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  • ステレオタイプ・スレットという問題とニュースレターの果たす役割

    竹原 裕子, 溝尾 妙子, 小林 純子, 坂本 美咲, 新田 薫, 工藤 由里絵, 安井 和也, 菊池 覚次, 黒田 新士, 吉田 龍一, 岡崎 幹生, 杉本 誠一郎, 枝園 忠彦, 小谷 恭弘, 豊岡 伸一, 笠原 真悟, 藤原 俊義, 土井原 博義

    日本外科学会定期学術集会抄録集   122回   SP - 6   2022.4

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  • 【Transplant Physician育成】肺移植における肺移植内科医育成の必要性

    平間 崇, 春藤 裕樹, 前田 寿美子, 中島 崇裕, 佐藤 雅昭, 松田 安史, 狩野 孝, 中島 大輔, 杉本 誠一郎, 早稲田 龍一, 松本 桂太郎, 岡田 克典

    移植   56 ( 4 )   341 - 346   2022.2

  • 著明な左下葉肺水腫を呈したグラフトによる脳死左片肺移植の経験

    松原慧, 杉本誠一郎, 川名伸一, 久保友次郎, 清水大, 石上恵美, 石原恵, 橋本好平, 田中真, 三好健太郎, 豊岡伸一, 豊岡伸一

    日本肺および心肺移植研究会プログラム・抄録集   38th   2022

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  • 移植直前の二次性肺高血圧が片肺移植後の予後に与える影響~両肺移植との比較~

    清水大, 三好健太郎, 杉本誠一郎, 久保友次郎, 川名伸一, 松原慧, 田中真, 岡崎幹生, 豊岡伸一

    日本肺および心肺移植研究会プログラム・抄録集   38th   2022

  • 脳死両肺移植後CLADによる高炭酸ガス血症に対する治療戦略:日中のリハビリテーションと夜間の人工呼吸器管理

    調枝治樹, 田中真, 松原慧, 枝園和彦, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    日本肺および心肺移植研究会プログラム・抄録集   38th   2022

  • 心臓死ドナーを脳死ドナー基準で分類した場合の心臓死肺移植後成績

    田中真, MEJIRA Lucas Hoyos, GOMEZ-DE-ANTONIOA David, 松原慧, 枝園和彦, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    日本呼吸器外科学会総会(Web)   39th   2022

  • 胸骨骨折に伴うフレイルチェストに対してプレートとワイヤー固定法を用いて整復し得た一例

    調枝治樹, 田中真, 松原慧, 枝園和彦, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    日本呼吸器外科学会総会(Web)   39th   2022

  • 肉腫多発肺転移手術症例における好中球/リンパ球比(NLR)の検討

    山本寛斉, 松原慧, 田中真, 枝園和彦, 諏澤憲, 三好健太郎, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    日本呼吸器外科学会総会(Web)   39th   2022

  • 胸部薄切CTおよびFDG-PET/CTによる小型肺腺癌の組織学的悪性度予測

    吉川真生, 枝園和彦, 松原慧, 田中真, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    日本呼吸器外科学会総会(Web)   39th   2022

  • ジャポニカアレイNEOを用いた肺移植後の慢性腎臓病に関連する一塩基多型の同定

    富岡泰章, 杉本誠一郎, 川名伸一, 久保友次郎, 清水大, 松原慧, 田中真, 枝園和彦, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 豊岡伸一

    日本呼吸器外科学会総会(Web)   39th   2022

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  • 肺尖部の死腔充填を企図した有効な有茎広背筋弁の採取・充填法

    氏家裕征, 三好健太郎, 松原慧, 田中真, 枝園和彦, 諏澤憲, 山本寛斉, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    日本呼吸器外科学会総会(Web)   39th   2022

  • プレシジョン・メディシンの時代に呼吸器外科医が果たす役割

    枝園和彦, 枝園和彦, 諏澤憲, 山本寛斉, 岡崎幹生, 田中真, 三好健太郎, 杉本誠一郎, 遠西大輔, 冨田秀太, 豊岡伸一

    日本呼吸器外科学会総会(Web)   39th   2022

  • 脳死片肺移植の長期成績

    杉本誠一郎, 三好健太郎, 田中真, 松原慧, 諏澤憲, 枝園和彦, 山本寛斉, 岡崎幹生, 豊岡伸一

    日本呼吸器外科学会総会(Web)   39th   2022

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  • 呼吸器外科ロボット手術の教育方針:Solo Surgery化と適応拡大へのステップアップ方法

    岡崎幹生, 田中真, 枝園和彦, 諏澤憲, 三好健太郎, 山本寛斉, 杉本誠一郎, 豊岡伸一

    日本呼吸器外科学会総会(Web)   39th   2022

  • 肺移植後Primary Graft Dysfunctionに対する新規治療戦略In vivo Lung Recovery(IVLR)の開発

    松原慧, 三好健太郎, 黒崎毅史, 川名伸一, 久保友次郎, 清水大, 高寛, 橋本好平, 田中真, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    日本胸部外科学会定期学術集会(Web)   75th   2022

  • 肺移植後の長期成績と慢性期管理

    杉本誠一郎, 三好健太郎, 田中真, 松原彗, 橋本好平, 諏澤憲, 枝園和彦, 山本寛斉, 岡崎幹生, 豊岡伸一

    日本胸部外科学会定期学術集会(Web)   75th   2022

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  • Ex vivo lung perfusion技術を体内へ応用したIn vivo Lung Recoveryによる新規治療戦略

    松原慧, 三好健太郎, 黒崎毅史, 川名伸一, 久保友次郎, 清水大, 橋本好平, 田中真, 岡崎幹生, 杉本誠一郎, 豊岡伸一

    日本移植学会総会プログラム抄録集   58th (Web)   2022

  • 250例の経験からみた呼吸器外科ロボット手術がもたらしたもの,もたらすもの

    岡崎幹生, 田中真, 枝園和彦, 諏澤憲, 三好健太郎, 山本寛斉, 杉本誠一郎, 豊岡伸一

    日本ロボット外科学会学術集会プログラム・抄録集   14th   2022

  • 血漿Histidine-rich glycoprotein濃度と肺移植後一時移植機能不全との関係

    塩谷 俊雄, 杉本 誠一郎, 富岡 泰章, 田中 真, 諏澤 憲, 枝園 和彦, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   74回   LOD17 - 1   2021.10

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  • 当院での様々な開胸アプローチの経験

    田中 真, 富岡 泰章, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    肺癌   61 ( 6 )   572 - 572   2021.10

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  • 肉腫多発肺転移に対する肺切除術

    山本 寛斉, 田中 真, 枝園 和彦, 諏澤 憲, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    肺癌   61 ( 6 )   663 - 663   2021.10

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  • OSNA法を用いた肺がん所属リンパ節転移診断の臨床有用性の検討

    諏澤 憲, 難波 圭, 枝園 和彦, 三浦 章博, 荒木 恒太, 宮内 俊策, 中田 憲太郎, 富岡 泰章, 田中 真, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    肺癌   61 ( 6 )   666 - 666   2021.10

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  • 気管支断端被覆の適応と方法 局所進行非小細胞肺癌に対する術前化学放射線療法後肺切除術における気管支断端および吻合部被覆の検討

    土生 智大, 山本 寛斉, 田中 真, 諏澤 憲, 枝園 和彦, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   74回   LDB2 - 5   2021.10

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  • 綿密な術前準備を行った低肺機能患者の両側続発性高度気胸の1手術例

    土生 智大, 諏澤 憲, 坂田 龍平, 久保 友次郎, 岩田 一馬, 松田 直樹, 富岡 泰章, 塩谷 俊雄, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   74回   LCPA2 - 1   2021.10

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  • 片肺移植における二次性肺高血圧の影響 当院の片側脳死肺移植症例の検討から

    清水 大, 三好 健太郎, 杉本 誠一郎, 久保 友次郎, 川名 伸一, 富岡 泰章, 松原 慧, 田中 真, 岡崎 幹生, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   74回   LOP15 - 2   2021.10

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  • 複雑気管支形成の適応、手術手技と成績 局所進行非小細胞肺癌に対する導入化学放射線療法後の複雑気管支形成術

    山本 寛斉, 田中 真, 枝園 和彦, 諏澤 憲, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   74回   LPD2 - 7   2021.10

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  • 未来のための今 大河の時代に入った心臓移植・肺移植 心停止下肺移植 本邦での挑戦

    田中 真, Mejia Lucas Hoyos, Gomez-De-Antonioa David, 松原 慧, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    日本胸部外科学会定期学術集会   74回   SP7 - 6   2021.10

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  • 肉腫多発肺転移に対する肺切除術

    山本 寛斉, 田中 真, 枝園 和彦, 諏澤 憲, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    肺癌   61 ( 6 )   663 - 663   2021.10

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  • 当院での様々な開胸アプローチの経験

    田中 真, 富岡 泰章, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    肺癌   61 ( 6 )   572 - 572   2021.10

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  • OSNA法を用いた肺がん所属リンパ節転移診断の臨床有用性の検討

    諏澤 憲, 難波 圭, 枝園 和彦, 三浦 章博, 荒木 恒太, 宮内 俊策, 中田 憲太郎, 富岡 泰章, 田中 真, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    肺癌   61 ( 6 )   666 - 666   2021.10

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  • 当院におけるロボット支援下呼吸器外科手術の現状と安全性確保の工夫

    岡崎幹生, 田中真, 枝園和彦, 諏澤憲, 三好健太郎, 山本寛斉, 杉本誠一郎, 山根正修, 豊岡伸一

    第96回中国四国外科学会総会   2021.9

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  • 左上葉切除後の低肺機能を伴った右下葉肺癌に対して左下葉と右上葉の術中肺換気により 右S6 スリーブ区域切除術を施行した一例

    林直宏, 山本寛斉, 土生智大, 氏家裕征, 大亀正義, 田中真, 枝園和彦, 諏澤憲, 三好健太郎, 岡崎幹生, 杉本誠一郎, 山根正修, 豊岡伸一

    第96回中国四国外科学会総会   2021.9

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  • 肺移植に関連した感染症(待機中から術後慢性期まで) Clostridioides difficile感染症診療ガイドライン作成に伴う当院での肺移植周術期の検討

    久保 友次郎, 田中 真, 石上 恵美, 石原 恵, 坂田 龍平, 富岡 泰章, 枝園 和彦, 諏澤 憲, 大谷 真二, 山本 寛斉, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   56 ( 総会臨時 )   SSY4 - 4   2021.9

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  • マウス異所性気管移植モデルを用いたS100A8/A9抗体の慢性移植肺機能不全に対する効果の検討

    清水 大, 岡崎 幹生, 木下 理恵, 中田 憲太郎, 三好 健太郎, 大谷 真二, 杉本 誠一郎, 山根 正修, 阪口 政清, 豊岡 伸一

    移植   56 ( 総会臨時 )   P2 - 11   2021.9

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  • 生体肺移植後CLADにおける2019年ISHLT新基準にもとづく予後評価

    松原 慧, 三好 健太郎, 大谷 真二, 川名 伸一, 久保 友次郎, 清水 大, 富岡 泰章, 田中 真, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   56 ( 総会臨時 )   O23 - 1   2021.9

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  • 肺移植におけるドナー不足にどう取組むか 心停止ドナー肺移植、スペインでの経験を踏まえて

    田中 真, 石上 恵美, 石原 恵, 富岡 泰章, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   56 ( 総会臨時 )   SSY9 - 4   2021.9

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  • 肺移植後の慢性期合併症とその管理 肺移植後の慢性腎臓病に対して血液透析を導入した症例の検討

    富岡 泰章, 杉本 誠一郎, 川名 伸一, 久保 友次郎, 清水 大, 松原 慧, 田中 真, 枝園 和彦, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 山根 正, 豊岡 伸一

    移植   56 ( 総会臨時 )   SWS8 - 4   2021.9

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  • 肺移植に関連した感染症(待機中から術後慢性期まで) びまん性汎細気管支炎に対する肺移植後の慢性期管理と長期成績

    杉本 誠一郎, 三好 健太郎, 田中 真, 富岡 泰章, 石原 恵, 石上 恵美, 諏澤 憲, 枝園 和彦, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    移植   56 ( 総会臨時 )   SSY4 - 5   2021.9

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  • 肺移植における多職種連携 新型コロナウイルス感染症(COVID-19)流行下での肺移植後患者フォローの工夫と課題

    石原 恵, 杉本 誠一郎, 石上 恵美, 鶴園 真理, 山下 里美, 難波 由美子, 富岡 泰章, 田中 真, 三好 健太郎, 大谷 真二, 山根 正修, 豊岡 伸一

    移植   56 ( 総会臨時 )   SWS3 - 2   2021.9

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  • 術前診断し、治療介入することで安全に切除し得た後縦隔Paraganglioma の一例

    中惇太, 三好健太郎, 氏家裕征, 富岡泰章, 田中真, 枝園和彦, 諏澤憲, 山本寛斉, 岡崎幹生, 杉本誠一郎, 山根正修, 豊岡伸一

    第59回日本肺癌学会 中国・四国支部学術集会   2021.8

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  • 生体肺移植後と脳死肺移植後の慢性移植肺機能不全(CLAD)の比較

    杉本誠一郎, 三好健太郎, 田中 真, 富岡 泰章, 枝園 和彦, 諏澤 憲, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    第59回日本肺癌学会 中国・四国支部学術集会   2021.8

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  • BKウイルス感染症による出血性膀胱炎で周術期治療に難渋した小児生体肺移植の1例

    富岡 泰章, 大谷 真二, 石上 恵美, 石原 恵, 松原 慧, 清水 大, 山本 治慎, 塩谷 俊雄, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   56 ( 1 )   100 - 100   2021.7

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  • 脊柱側彎症患者に対する脳死両肺移植、術後合併症の経験

    山本 治慎, 大谷 真二, 清水 大, 松原 慧, 富岡 泰章, 塩谷 俊雄, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   56 ( 1 )   102 - 102   2021.7

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  • シャント造設を契機に片側肺の肺水腫及び肺高血圧を来した両側生体肺移植後CLADの一例

    清水 大, 三好 健太郎, 東馬 智子, 松田 裕介, 松原 慧, 富岡 泰章, 塩谷 俊雄, 山本 治慎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   56 ( 1 )   104 - 104   2021.7

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  • 肺移植後成績の芳しくないレシピエント群-乳幼児肺移植

    大谷 真二, 石原 恵, 石上 恵美, 松原 慧, 清水 大, 富岡 泰章, 山本 治慎, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   56 ( 1 )   76 - 76   2021.7

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  • 本邦における肺移植時の一酸化窒素ガス(NO)使用状況に関する実態調査

    吉安 展将, 佐藤 雅昭, 中島 大輔, 富岡 泰章, 渡辺 有為, 白石 武史, 舟木 壮一郎, 前田 寿美子, 朝重 耕一, 中島 崇裕, 土谷 智史, 杉本 誠一郎, 吉野 一郎, 永安 武, 千田 雅之, 南 正人, 岡田 克典, 豊岡 伸一, 伊達 洋至, 中島 淳

    移植   56 ( 1 )   88 - 88   2021.7

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  • Split lung transplantation for small children: Bilateral segmental lung transplantation using split adult living-donor lower lobe

    Seiichiro Sugimoto, Shinji Otani, Kentaroh Miyoshi, Shin Tanaka, Yasuaki Tomioka, Ken Suzawa, Hiromasa Yamamoto, Mikio Okazaki, Masaomi Yamane, Shinichi Toyooka

    International Symposium of Pediatric Heart and Lung Transplantation   2021.7

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  • 当院における術前禁煙指導の新たな取り組みと課題

    久保友次郎, 三好健太郎, 富岡 泰章, 塩谷 俊雄, 諏澤 憲, 大谷 真二, 山本 寛斉, 岡崎 幹生, 杉本誠一郎, 山根 正修, 小林 求, 豊岡 伸一

    第64回関西胸部外科学会学術集会   72 - 72   2021.6

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  • 肺移植から応用できる呼吸器外科手術手技 Invited

    杉本誠一郎

    第64回関西胸部外科学会学術集会   63 - 63   2021.6

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  • ロボット支援手術第2世代術者のラーニングカーブ

    大谷 真二, 岡崎 幹生, 坂田 龍平, 松田 直樹, 岩田 一馬, 高津 史明, 諏澤 憲, 三好 健太郎, 山本 寛斉, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本呼吸器外科学会雑誌   35 ( 3 )   MO58 - 1   2021.5

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  • 肺移植における最適な術前予後予測スコアリング法 9つの術前予後予測スコアリング法の検証から

    山本 治慎, 杉本 誠一郎, 富岡 泰章, 塩谷 俊雄, 清水 大, 松原 慧, 三好 健太郎, 大谷 真二, 岡崎 幹生, 山根 正修, 豊岡 伸一

    日本呼吸器外科学会雑誌   35 ( 3 )   O18 - 5   2021.5

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  • 肺がん治療発展を目指した呼吸器外科医の役割 家族性肺がんの経験

    諏澤 憲, 山本 寛斉, 三好 健太郎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本呼吸器外科学会雑誌   35 ( 3 )   MO10 - 3   2021.5

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  • 肺移植後移植片慢性機能不全におけるGoddard scoreの検討

    塩谷 俊雄, 杉本 誠一郎, 山本 治慎, 富岡 泰章, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    日本呼吸器外科学会雑誌   35 ( 3 )   O18 - 3   2021.5

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  • 肺移植患者の周術期におけるClostridioides difficile感染症の検討

    坂田 龍平, 大谷 真二, 石上 恵美, 石原 恵, 土生 智大, 岩田 一馬, 久保 友次郎, 松田 直樹, 清水 大, 松原 慧, 富岡 泰章, 山本 治慎, 塩谷 俊雄, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本呼吸器外科学会雑誌   35 ( 3 )   O18 - 4   2021.5

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  • N2肺癌に対する術前導入化学放射線療法後手術症例における好中球/リンパ球比の検討

    山本 寛斉, 津高 慎平, 富岡 泰章, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本呼吸器外科学会雑誌   35 ( 3 )   O8 - 1   2021.5

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  • UNCX遺伝子多型と肺移植後の腎機能障害との関係

    富岡 泰章, 杉本 誠一郎, 山本 治慎, 清水 大, 松原 慧, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    日本呼吸器外科学会雑誌   35 ( 3 )   RO17 - 2   2021.5

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  • Vessel sealerを常時用いたRATS手技

    岡崎 幹生, 諏澤 憲, 大谷 真二, 三好 健太郎, 山本 寛斉, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本呼吸器外科学会雑誌   35 ( 3 )   RV5 - 1   2021.5

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  • 肺移植における予後改善に向けての取組 生体肺移植と脳死肺移植の違いに着目した慢性移植肺機能不全(CLAD)の早期診断を目指した取り組み

    杉本 誠一郎, 塩谷 俊雄, 山本 治慎, 富岡 泰章, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    日本呼吸器外科学会雑誌   35 ( 3 )   PD2 - 4   2021.5

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  • RATS? VATS? Uniportal VATS?〜あなたならどのアプローチを選ぶ?〜 肥満症例や不全分葉症例から見たRATSの有用性

    岡崎 幹生, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本呼吸器外科学会雑誌   35 ( 3 )   PD3 - 3   2021.5

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  • 当院における小児肺移植の成績

    大谷 真二, 富岡 泰章, 松原 慧, 清水 大, 山本 治慎, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本外科学会定期学術集会抄録集   121回   PS - 8   2021.4

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  • Combination of Neutrophil to Lymphocyte Ratio and Glasgow Prognostic Score Improves Prognostic Accuracy in Lung Transplantation: Validation of 9 Preoperative Prognostic Scoring Methods

    H. Yamamoto, S. Sugimoto, E. Suzuki, Y. Tomioka, T. Shiotani, D. Shimizu, K. Matsubara, K. Miyoshi, S. Otani, M. Okazaki, M. Yamane, S. Toyooka

    The Journal of Heart and Lung Transplantation   40 ( 4 )   2021.4

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    DOI: 10.1016/j.healun.2021.01.1007

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  • Plasma Levels of Histidine-Rich Glycoprotein are Associated with the Development of Primary Graft Dysfunction after Lung Transplantation

    T. Shiotani, S. Sugimoto, H. Yamamoto, K. Matsubara, D. Shimizu, K. Nakata, Y. Tomioka, K. Miyoshi, S. Otani, M. Okazaki, M. Yamane, S. Toyooka

    The Journal of Heart and Lung Transplantation   40 ( 4 )   2021.4

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    DOI: 10.1016/j.healun.2021.01.455

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  • The UNCX Polymorphism is Associated with the Development of Renal Dysfunction after Lung Transplantation

    Y. Tomioka, S. Sugimoto, K. Matsubara, D. Shimizu, H. Yamamoto, T. Shiotani, K. Miyoshi, S. Ohtani, M. Okazaki, M. Yamane, S. Toyooka

    The Journal of Heart and Lung Transplantation   40 ( 4 )   S346 - S347   2021.4

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    DOI: 10.1016/j.healun.2021.01.977

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  • Anti-HMGB1 Monoclonal Antibody Ameliorates Lung Ischemia Reperfusion Injury in Mice

    K. Nakata, M. Okazaki, S. Sugimoto, M. Yamane, S. Toyooka

    The Journal of Heart and Lung Transplantation   40 ( 4 )   2021.4

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    DOI: 10.1016/j.healun.2021.01.452

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  • Risk Assessment of Chronic Lung Allograft Dysfunction Phenotypes after Living-Donor Lobar Lung Transplantation According to the 2019 ISHLT Classification System

    K. Matsubara, S. Otani, D. Shimizu, Y. Tomioka, T. Shiotani, H. Yamamoto, K. Miyoshi, M. Okazaki, S. Sugimoto, M. Yamane, S. Toyooka

    The Journal of Heart and Lung Transplantation   40 ( 4 )   2021.4

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    DOI: 10.1016/j.healun.2021.01.867

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  • Post-Transplant Lymphoproliferative Disorder in Lung Transplantation: A Single-Center Experience in Japan

    D. Shimizu, S. Otani, Y. Tomioka, T. Shiotani, H. Yamamoto, K. Miyoshi, M. Okazaki, S. Sugimoto, M. Yamane, S. Toyooka

    The Journal of Heart and Lung Transplantation   40 ( 4 )   2021.4

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    DOI: 10.1016/j.healun.2021.01.884

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  • Pediatric Lung Transplantation−Intermediate Outcomes of a Japanese Center

    S. Otani, Y. Tomioka, K. Matsubara, D. Shimizu, H. Yamamoto, T. Shiotani, K. Suzawa, K. Miyoshi, H. Yamamoto, M. Okazaki, S. Sugimoto, M. Yamane, S. Toyooka

    The Journal of Heart and Lung Transplantation   40 ( 4 )   2021.4

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    DOI: 10.1016/j.healun.2021.01.995

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  • 脳死肺移植後、タクロリムス濃度調整に難渋した、クローン病合併レシピエントの1例

    松原 慧, 大谷 真二, 金 聖暎, 今井 祥子, 開原 裕子, 長谷川 祐子, 清水 大, 富岡 泰章, 山本 治慎, 塩谷 俊雄, 三好 健太郎, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    移植   55 ( 4 )   508 - 508   2021.3

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  • 肺移植における社会保険制度の現状と問題点 コーディネータの立場から

    大河 知世, 黒崎 毅史, 大谷 真二, 杉本 誠一郎, 大藤 剛宏

    移植   55 ( 4 )   474 - 474   2021.3

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  • 高IgE症候群による気管支拡張症に対して両側脳死肺移植を施行した1例

    清水 大, 大谷 真二, 富岡 泰章, 松原 慧, 塩谷 俊雄, 山本 治慎, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    移植   55 ( 4 )   507 - 507   2021.3

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  • 肺移植手術手技を応用した自家肺移植

    塩谷 俊雄, 大谷 真二, 青景 圭樹, 黒崎 毅史, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一, 坪井 正博, 大藤 剛宏

    移植   55 ( 4 )   451 - 451   2021.3

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  • 反転肺移植術の可能性 当院で経験した3症例

    山本 治慎, 大谷 真二, 日笠 友起子, 黒崎 毅史, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一, 小林 求, 大藤 剛宏

    移植   55 ( 4 )   453 - 453   2021.3

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  • 小児に対するABO血液型不一致の両側脳死肺移植の経験

    塩谷 俊雄, 杉本 誠一郎, 松原 慧, 富岡 泰章, 清水 大, 山本 治慎, 三好 健太郎, 大谷 真二, 岡崎 幹生, 山根 正修, 大藤 剛宏, 豊岡 伸一

    移植   55 ( 4 )   491 - 491   2021.3

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  • 脳死片肺移植を施行した多中心性キャッスルマン病の1例

    富岡 泰章, 大谷 真二, 松原 慧, 清水 大, 山本 治慎, 塩谷 俊雄, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    移植   55 ( 4 )   506 - 506   2021.3

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  • Robot-assisted mediastinal tumor resection with various position

    OKAZAKI Mikio, SUZAWA Ken, SHIOTANI Toshio, MIYOSHI Kentaro, OTANI Shinji, YAMAMOTO Hiromasa, SUGIMOTO Seiichiro, YAMANE Masaomi, TOYOOKA Shinichi

    日本内視鏡外科学会総会(Web)   33rd   2021

  • A growing demand for transplant physicians for lung transplantation in Japan

    平間崇, 平間崇, 春藤裕樹, 前田寿美子, 中島崇裕, 中島崇裕, 佐藤雅昭, 松田安史, 狩野孝, 中島大輔, 杉本誠一郎, 早稲田龍一, 松本桂太郎, 岡田克典, 岡田克典

    移植(Web)   56 ( 4 )   2021

  • 移植実施施設における肺移植内科医の役割

    平間 崇, 前田 寿美子, 中島 崇裕, 狩野 孝, 中島 大輔, 杉本 誠一郎, 早稲田 龍一, 松本 桂太郎, 佐藤 雅昭

    移植   55 ( 総会臨時 )   224 - 224   2020.10

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  • 当院の肺移植後リンパ増殖性疾患7例の検討 治療後のCLAD発症と日和見感染症による死亡をどう防ぐか

    清水 大, 大谷 真二, 富岡 泰章, 松原 慧, 塩谷 俊雄, 山本 治慎, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   55 ( 総会臨時 )   246 - 246   2020.10

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  • 肺移植におけるLiquid biopsy ドナー由来血中遊離DNAとマイクロRNA

    杉本 誠一郎, 塩谷 俊雄, 富岡 泰章, 石上 恵美, 石原 恵, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    移植   55 ( 総会臨時 )   242 - 242   2020.10

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  • 肺移植待機患者の予後予測におけるPrognostic Nutrition Index(PNI)の有用性

    松原 慧, 大谷 真二, 清水 大, 富岡 泰章, 山本 治慎, 塩谷 俊雄, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   55 ( 総会臨時 )   353 - 353   2020.10

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  • 当院における高齢者レシピエント症例の検討

    富岡 泰章, 大谷 真二, 清水 大, 松原 慧, 山本 治慎, 塩谷 俊雄, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   55 ( 総会臨時 )   253 - 253   2020.10

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  • ハイリスク症例をいかに手術に繋げるか? 導入放射線化学療法後の局所進行非小細胞肺癌に対する手術後に反回神経麻痺を発症した症例の検討

    杉本 誠一郎, 諏澤 憲, 富岡 泰章, 塩谷 俊雄, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    肺癌   60 ( 6 )   492 - 492   2020.10

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  • 高分化腺癌-いつ切るの? すりガラス成分を有する小型肺癌に対する治療の至適介入時期

    諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    肺癌   60 ( 6 )   484 - 484   2020.10

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  • 集学的治療が行われた局所進行肺癌患者における末梢血好中球/リンパ球比(NLR)の予後的意義について

    津高 慎平, 山本 寛斉, 諏澤 憲, 三好 健太郎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    肺癌   60 ( 6 )   658 - 658   2020.10

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  • 非小細胞肺癌手術症例と末梢血リンパ球/単球比とその継時的変化の関連の検討

    富岡 泰章, 山本 寛斉, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    肺癌   60 ( 6 )   587 - 587   2020.10

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  • 最新低侵襲手術におけるリンパ節郭清手技:単孔式VATS vs ロボット支援手術 RATSにおけるリンパ節郭清手技

    岡崎 幹生, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    肺癌   60 ( 6 )   464 - 464   2020.10

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  • 間質性肺炎合併肺癌:To treat, or not to treat? 間質性肺炎合併肺癌に対する外科的治療

    山本 寛斉, 松原 慧, 富岡 泰章, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    肺癌   60 ( 6 )   481 - 481   2020.10

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  • 肺癌との鑑別が困難であった器質化肺炎の1例

    富岡泰章, 大谷真二, 塩谷俊雄, 諏澤憲, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 山根正修, 豊岡伸一

    第95回中国四国外科学会総会   2020.10

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  • 生体肺移植ドナー手術において予定外の肺動脈再建が必要となった症例

    大谷真二, 富岡泰章, 松原 慧, 清水 大, 山本治慎, 塩谷俊雄, 諏澤 憲, 三好健太郎, 山本寛斉, 岡崎幹生, 杉本誠一郎, 山根正修, 豊岡伸一

    第95回中国四国外科学会総会   2020.10

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  • 初めて直腸間膜全切除を行った腹腔鏡下低位前方切除

    岩田一馬, 小畠誉也, 杉本誠一郎, 豊岡伸一

    第95回中国四国外科学会総会・第25回中国四国内視鏡外科研究会   2020.10

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  • 完全胸腔鏡下に右下葉切除を施行し得た、若年成人の先天性肺葉性肺気腫の1 例

    柳光剛志, 山本寛斉, 杉本誠一郎, 富岡泰章, 塩谷俊雄, 諏澤憲, 三好健太郎, 大谷真二, 岡﨑幹生, 山根正修, 豊岡伸一

    第95回中国四国外科学会総会   2020.10

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  • 肺移植手技を用いた中枢型広域浸潤肺癌に対する右上中葉拡大スリーブ切除

    三好健太郎, 伊達慶一, 山本治慎, 富岡泰章, 塩谷俊雄, 諏澤憲, 大谷真二, 山本寛斎, 岡﨑幹生, 杉本誠一郎, 山根正修, 豊岡伸一

    第95回中国四国外科学会総会   2020.10

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  • 新時代の肺癌治療〜集学的治療の一環としての外科手術 進行肺癌に対し完全治癒を目指した術前導入治療後の外科手術

    山根 正修, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 豊岡 伸一

    日本胸部外科学会定期学術集会   73回   LSY2 - 6   2020.10

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  • 肉腫多発肺転移手術症例における末梢血好中球/リンパ球比(NLR)の予後予測因子としての意義

    山本 寛斉, 富岡 泰章, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   73回   LOO2 - 2   2020.10

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  • 肺移植における抗HLA抗体と抗体関連拒絶反応 抗胸腺細胞グロブリンをfirst lineとした肺移植後急性期抗体関連拒絶反応の治療成績

    三好 健太郎, 大谷 真二, 杉本 誠一郎, 富岡 泰章, 塩谷 俊雄, 黒崎 毅史, 諏澤 憲, 山本 寛斎, 岡崎 幹生, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   73回   LWS1 - 1   2020.10

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  • ロボット支援手術におけるリンパ節郭清手技 VATS、単孔式VATSと比較して

    岡崎 幹生, 諏澤 憲, 富岡 泰章, 塩谷 俊雄, 三好 健太郎, 大谷 真二, 山本 寛斉, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   73回   LRS1 - 3   2020.10

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  • 肺移植における新しい肺保存法とグラフト機能評価法(ex vivo lung perfusion(EVLP)を含む) 肺移植における無気肺ドナーからの臓器保護的肺摘出法

    二萬 英斗, 三好 健太郎, 塩谷 俊雄, 山本 治慎, 黒崎 毅史, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   73回   LSY3 - 3   2020.10

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  • 間質性肺炎合併肺癌の予後における末梢血好中球/リンパ球比(NLR)の影響

    松原 慧, 山本 寛斉, 富岡 泰章, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    日本胸部外科学会定期学術集会   73回   LOO1 - 54   2020.10

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  • 地域枠医師に対する外科専門研修のあり方 充実した地域医療の実現を目指して

    黒田 新士, 吉田 龍一, 池田 宏国, 岡崎 幹生, 大澤 晋, 小谷 恭弘, 山根 正修, 杉本 誠一郎, 菊地 覚次, 安井 和也, 野田 卓男, 笠原 真悟, 豊岡 伸一, 土井原 博義, 藤原 俊義

    日本外科学会定期学術集会抄録集   120回   SP - 4   2020.8

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  • ウェットラボでのノンテクニカルスキル評価システムの有用性の検討

    山根 正修, 杉本 誠一郎, 岡崎 幹生, 豊岡 伸一

    日本呼吸器外科学会雑誌   34 ( 3 )   RO28 - 2   2020.8

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  • ロボット支援下肺葉切除術時の肺動脈損傷に対する対応

    岡崎 幹生, 諏澤 憲, 塩谷 俊雄, 三好 健太郎, 大谷 真二, 山本 寛斉, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    日本呼吸器外科学会雑誌   34 ( 3 )   V1 - 1   2020.8

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  • 右下肺静脈・左心房経由で左心室まで浸潤した小細胞肺癌に対する緊急手術の1例

    岡崎 幹生, 諏澤 憲, 塩谷 俊雄, 三好 健太郎, 大谷 真二, 山本 寛斉, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    日本呼吸器外科学会雑誌   34 ( 3 )   RV3 - 1   2020.8

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  • 肉腫多発肺転移に対する肺切除術

    山本 寛斉, 諏澤 憲, 三好 健太郎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    日本呼吸器外科学会雑誌   34 ( 3 )   O44 - 7   2020.8

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  • 臨床的N0・病理学的リンパ節転移陽性肺がんに対する肺切除の現状

    諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    日本呼吸器外科学会雑誌   34 ( 3 )   O3 - 1   2020.8

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  • 自然気胸後の器質化期膿胸に対する醸膿胸膜切除術 明瞭な臓側胸膜外層の同定に基づいた剥離

    清水 大, 三好 健太郎, 松原 慧, 山本 治慎, 諏澤 憲, 大谷 真二, 山本 寛斎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    日本呼吸器外科学会雑誌   34 ( 3 )   MO59 - 10   2020.8

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  • 抗HMGB1抗体による肺虚血再灌流障害の抑制

    中田 憲太郎, 岡崎 幹生, 清水 大, 宮内 俊作, 荒木 恒太, 三浦 章博, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 杉本 誠一郎, 山根 正修, 大藤 剛弘, 豊岡 伸一

    日本呼吸器外科学会雑誌   34 ( 3 )   O47 - 4   2020.8

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  • 肺移植の問題点と改善策 高度無気肺を合併したドナー肺による移植成績

    塩谷 俊雄, 杉本 誠一郎, 山本 治慎, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 大藤 剛宏, 豊岡 伸一

    日本呼吸器外科学会雑誌   34 ( 3 )   PD1 - 3   2020.8

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  • 肺移植から学ぶ呼吸器外科学 肺移植から学ぶゲノム医療

    杉本 誠一郎, 塩谷 俊雄, 山本 治慎, 田中 真, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 大藤 剛宏, 豊岡 伸一

    日本呼吸器外科学会雑誌   34 ( 3 )   S - 7   2020.8

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  • 気胸を合併し、発見された肺原発血管肉腫の1切除例

    毛利 謙吾, 岡崎 幹生, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    日本呼吸器外科学会雑誌   34 ( 3 )   SP4 - 3   2020.8

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  • 気管支断端瘻閉鎖後の治癒経過から考える治療方針

    山本 治慎, 三好 健太郎, 松原 慧, 塩谷 俊雄, 諏澤 憲, 大谷 真二, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    日本臨床外科学会雑誌   81 ( 6 )   1206 - 1206   2020.6

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  • 術中に胸腔間交通による医原性両側気胸を発症した1例

    富岡泰章, 大谷真二, 高津史明, 松原 慧, 津高慎平, 山本治慎, 塩谷俊雄, 諏澤 憲, 三好健太郎, 山本寛斉, 岡?幹生, 杉本誠一郎, 山根正修, 大藤剛宏, 豊岡伸一

    第63回関西胸部外科学会学術集会   2020.6

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  • スリーブ区域切除を駆使した肺機能温存手術

    諏澤憲, 三好健太郎, 大谷真二, 山本寛斉, 岡崎幹生, 杉本誠一郎, 山根正修, 豊岡伸一

    第63回関西胸部外科学会学術集会   2020.6

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  • CTガイド下生検では診断困難であった肺門部結節影

    松原 慧, 大谷 真二, 高津 史明, 富岡 泰章, 津高 慎平, 山本 治慎, 塩谷 俊雄, 難波 圭, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹雄, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    岡山医学会雑誌   132 ( 1 )   46 - 46   2020.4

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  • Plasma micro-RNA Levels are Associated with the Development of Chronic Lung Allograft Dysfunction after Bilateral Living-Donor and Cadaveric Lung Transplantation Reviewed

    T. Shiotani, S. Sugimoto, H. Yamamoto, D. Shimizu, K. Miyoshi, S. Otani, M. Okazaki, M. Yamane, T. Oto, S. Toyooka

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation   39 ( 4 )   S194   2020.4

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    Copyright © 2020. Published by Elsevier Inc. PURPOSE: Micro-RNAs (miRNAs) regulate genes by selectively silencing their target messenger RNAs. Recently, serum levels of miRNA related to pulmonary fibrosis (miR-21 and miR-155), have been shown to be associated with the development of chronic lung allograft dysfunction (CLAD) after cadaveric lung transplantation (CLT). We investigated the relationship between miRNAs levels and CLAD after bilateral living-donor lobar lung transplantation (LDLLT) and CLT. METHODS: Blood samples were collected from a total of 70 patients who underwent bilateral LDLLT (n=39) and bilateral CLT (n=31), including patients with CLAD (the CLAD group, n=25) and those without CLAD (the non-CLAD group, n=45). Plasma miRNA levels (miR-21 and miR-155) were quantified using real-time PCR and compared between the two groups. The relationship between miRNA levels and the results of pulmonary function tests at the onset of CLAD was assessed. Appropriate cut-off values of miRNA levels were set for the diagnosis of CLAD. RESULTS: The median follow-up period was 3074 (1071-7523) days. Plasma miRNA levels of the CLAD group were significantly higher than those of the non-CLAD group (miR-21, P<0.001; miR-155, P=0.013) (Fig. 1). In the CLAD group, miRNA levels after LDLLT were comparable to those after CLT. Moreover, miRNA levels were significantly negatively correlated with the baseline values of forced expiratory volume in 1 second (FEV1) (miR-21, P<0.001; miR-155, P=0.039) and those of total lung cavity (TLC) (miR-21, P<0.001; miR-155, P=0.0012) (Fig. 2). An ROC analysis of the performance of miR-21 level as a marker of CLAD yielded an AUC of 0.94 at a threshold level of 6.51. Patients with miR-21 level≥6.51 showed significantly better CLAD-free survival than those with miR-21 level<6.51 (P<0.001) (Fig. 3). CONCLUSION: Plasma miRNA levels are associated with the development of CLAD after bilateral LDLLT and CLT, and might be a potential biomarker for the diagnosis of CLAD.

    DOI: 10.1016/j.healun.2020.01.792

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  • Prognostic Nutritional Index Negatively Correlates with Lung Allocation Score and Predicts Survival after Both Cadaveric and Living-Donor Lobar Lung Transplantation

    H. Yamamoto, S. Sugimoto, T. Shiotani, K. Miyoshi, S. Otani, M. Okazaki, M. Yamane, T. Oto, S. Toyooka

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation   39 ( 4 )   S311   2020.4

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    Copyright © 2020. Published by Elsevier Inc. PURPOSE: The preoperative nutritional status affects the clinical outcome of surgery. To predict the clinical outcome, a prognostic nutritional index (PNI) calculated using serum albumin levels (ALB) and total lymphocyte count (TLC) has been shown to be valuable in various fields of surgery. In this study, we investigated the relationship between PNI and lung allocation score (LAS) as well as the impact of PNI on outcomes of lung transplantation (LT), including cadaveric lung transplantation (CLT) and living-donor lobar lung transplantation (LDLLT). METHODS: Between June 2003 and August 2016, a total of 127 patients underwent LT at Okayama University Hospital, including 71 recipients of CLT and 56 recipients of LDLLT. The PNI was calculated by the following equation: PNI = (10 × ALB(g/dl)+(0.005 × TLC(/mm3)). The overall survival was evaluated by univariate analysis (the log rank test) and multivariate analysis (the Cox proportional hazard regression model) using preoperative factors, including sex, age, BMI, diagnosis, oxygen concentration, mechanical ventilation, tracheostomy, ECMO support, use of glucocorticoids, serum creatinine level, diabetes mellitus, LAS, and PNI. RESULTS: PNI was significantly negatively correlated with LAS (r=-0.3, P=0.00062) (Fig. 1A). The univariate analysis revealed that the overall survival was significantly worse in the patients with age>28 (P=0.047), BMI<24.2 (P=0.0098), LAS>58.04 (P=0.000072), PNI<46.35 (P=0.018) (Fig. 1B). The multivariate analysis demonstrated that age (P=0.00093), BMI (P=0.0024), and PNI (P=0.0047) were independent prognostic factors of worse outcome. In the subgroup analysis, low PNI is a significant prognostic factor of worse survival after CLT (P=0.015) (Fig. 1C) and LDLLT (P=0.041) (Fig. 1D). CONCLUSION: Preoperative nutritional evaluation using PNI could contribute to the assessment of LT recipient's severity and predict survival after both CLT and LDLLT.

    DOI: 10.1016/j.healun.2020.01.700

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  • 肺移植における内科医の役割

    平間 崇, 前田 寿美子, 中島 崇裕, 狩野 孝, 中島 大輔, 杉本 誠一郎, 早稲田 龍一, 松本 桂太郎, 佐藤 雅昭

    移植   55   224_1 - 224_1   2020

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    <p>日本では移植施設の大半で移植外科医が肺移植患者の外来フォローを行なってきた。片肺移植が半数を占める日本では、原疾患の管理と固有肺の治療は移植後も重要であり、欧米のように呼吸器内科医が移植後管理をリードして診療をする時期に差し掛かっているのではないかと考えた。そこで、肺移植施設に勤務する移植外科医9名と呼吸器内科医9名、また非移植施設に勤務する呼吸器内科医14名にアンケート調査を実施し、移植施設における現在の外科医と内科医の介入度を調査した。また、移植医療について内科医が関われること、関わりにくいことを分析した。それらから、①呼吸器外科医は移植前、周術期、移植後と移植診療の大半を負担していること、②呼吸器内科医は移植前、移植後への介入に関心があるがその機会と教育の場が少ないこと、③内科医として移植患者を集中的に診察できる教育システムの充実させることが必要であることがわかった。これらを日本移植学会の今後の課題にできるか検討したい。</p>

    DOI: 10.11386/jst.55.Supplement_224_1

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  • 当院における高齢者レシピエント症例の検討

    富岡 泰章, 大谷 真二, 清水 大, 松原 慧, 山本 治慎, 塩谷 俊雄, 三好 健太郎, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 豊岡 伸一

    移植   55 ( Supplement )   253_1 - 253_1   2020

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    【背景】日本における高齢者レシピエントの長期成績に関しての報告は少ない.今回当院における高齢者レシピエントの長期成績について後方視的に検討した.【対象と方法】1998年1月~2020年1月に施行した18歳以上の肺移植症例161例を対象とした.60歳以上の高齢群(H群:n=10)と18-59歳の非高齢群(L群:n=151)の2群に分けて,全生存期間(OS)およびCLAD発症までの期間(CFS)について解析を行った.【結果】H群ではL群と比較して片肺移植(p=0.03),間質性肺炎(p=0.02),男性(p=0.04)の割合が有意に多かった.BMI,ドナー年齢,総虚血時間,LASスコアには有意差は認めなかった.H群とL群の5年OSはそれぞれ51.9%と75.5%であり,有意差を認めた(p=0.02).H群とL群の5年CFSはそれぞれ53.3%と72.5%であった.サブグループ解析では,H群の片肺移植症例(5年:OS 25%)は両肺移植症例(5年OS:75%)と比較してOSが悪い傾向にあった(p=0.08)が,H群の両肺移植症例はL群の両肺移植症例(5年OS:74.2%)と比較しても同等の成績であった(p=0.5).【結語】60歳以上のレシピエントの成績は60歳未満と比較し不良だが,両肺移植がより望ましい可能性が示唆された.

    DOI: 10.11386/jst.55.supplement_253_1

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  • 肺移植におけるLiquid biopsy:ドナー由来血中遊離DNAとマイクロRNA

    杉本 誠一郎, 塩谷 俊雄, 富岡 泰章, 石上 恵美, 石原 恵, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 豊岡 伸一

    移植   55 ( Supplement )   242_2 - 242_2   2020

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    【背景】低侵襲に血液や体液を採取し解析を行うLiquid biopsyは、癌領域では既に臨床応用され治療方針の決定に一役買っているが、移植領域ではまだ発展途上である。当科では肺移植におけるLiquid biopsyとして、ドナー由来血中遊離DNA(dd-cf-DNA)とマイクロRNA(miRNA)を標的にした研究を行ってきたため、その成果を報告する。【方法】ドナーとレシピエントの一塩基多型を比較してdd-cf-DNAを測定し、生体肺移植後の急性拒絶反応(AR)における診断的意義を検討した。次にレシピエントのみの検体で評価できるmiRNAを測定し、脳死・生体肺移植後の移植片慢性機能不全(CLAD)における診断的意義を検討した。【結果】dd-cf-DNAは、感染群(p=0.028)や安定群(p=0.001)よりAR群で有意に増加しており、生体肺移植後ARの診断に有用であった(Sci Rep 2018)。また線維化に関与するmiRNAが、非CLAD群よりCLAD群で有意に増加しており(p=0.008)、一秒量の変化率とも相関し(p=0.014)、CLAD診断に有用であった。【結論】肺移植のLiquid biopsy として、dd-cf-DNAは生体肺移植後ARの診断に、またmiRNAはCLADの診断に有用である。今後の臨床応用を目指して症例数の集積と簡便で精度の高い方法の開発が望まれる。

    DOI: 10.11386/jst.55.supplement_242_2

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  • 人生100年時代の肺がん治療 外科医の立場から

    宗 淳一, 富沢 健二, 武本 智樹, 小原 秀太, 藤野 智大, 古賀 教将, 西野 将矢, 濱田 顕, 千葉 眞人, 須田 健一, 杉本 誠一郎, 豊岡 伸一, 光冨 徹哉

    肺癌   59 ( 6 )   853 - 853   2019.11

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  • 肉腫多発肺転移に対する肺切除術

    難波圭, 豊岡伸一, 枝園和彦, 山本寛斉, 宗淳一, 黒崎毅史, 三好健太郎, 大谷真二, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   59 ( 6 )   684 - 684   2019.11

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  • 肺癌との鑑別が困難であった肺結節性リンパ過形成の1例

    富岡 泰章, 山本 寛斉, 松原 慧, 山本 治慎, 塩谷 俊雄, 難波 圭, 諏澤 憲, 三好 健太郎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    肺癌   59 ( 6 )   878 - 878   2019.11

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  • 頭頸部癌治療歴を有する非小細胞肺がん患者に対する手術症例の検討

    高津 史明, 諏澤 憲, 枝園 和彦, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    肺癌   59 ( 6 )   711 - 711   2019.11

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  • サルベージ治療・オリゴ再発に対する局所治療戦略 術前化学放射線療法後手術を行った局所進行肺癌術後再発症例の臨床経過

    諏澤 憲, 枝園 和彦, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    肺癌   59 ( 6 )   586 - 586   2019.11

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  • 定型カルチノイドを伴うびまん性特発性肺神経内分泌過形成の1例

    富岡 泰章, 山本 寛斉, 松原 慧, 山本 治慎, 塩谷 俊雄, 難波 圭, 諏澤 憲, 三好 健太郎, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    肺癌   59 ( 6 )   878 - 878   2019.11

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  • 腹臥位による後方アプローチ併用ロボット支援下ダンベル型神経鞘腫摘出術

    岡崎 幹生, 諏澤 憲, 塩谷 俊雄, 三好 健太郎, 大谷 真二, 山本 寛斉, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    肺癌   59 ( 6 )   745 - 745   2019.11

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  • Bリンパ球過形成を伴う小結節性胸腺腫瘍の1切除例

    上山 廉起, 岡崎 幹生, 塩谷 俊雄, 諏澤 憲, 三好 健太郎, 大谷 真二, 山本 寛斉, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    肺癌   59 ( 6 )   923 - 923   2019.11

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  • 人生100年時代の肺がん治療 外科医の立場から

    宗 淳一, 富沢 健二, 武本 智樹, 小原 秀太, 藤野 智大, 古賀 教将, 西野 将矢, 濱田 顕, 千葉 眞人, 須田 健一, 杉本 誠一郎, 豊岡 伸一, 光冨 徹哉

    肺癌   59 ( 6 )   853 - 853   2019.11

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  • EP1.18-08 Pulmonary Lobectomy and Completion Pneumonectomy for Ipsilateral Lung Cancer After Radical Resection

    M. Okazaki, K. Suzawa, K. Miyoshi, S. Otani, H. Yamamoto, S. Sugimoto, M. Yamane, T. Oto, S. Toyooka

    Journal of Thoracic Oncology   14 ( 10 )   2019.10

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    DOI: 10.1016/j.jtho.2019.08.2453

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  • SPECT/CTを用いて切除範囲を評価した左肺底動脈大動脈起始症の1例

    山本 諒, 杉本 誠一郎, 中田 憲太郎, 塩谷 俊雄, 三好 健太郎, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 大藤 剛宏, 豊岡 伸一, 末澤 孝徳

    肺癌   59 ( 5 )   509 - 509   2019.10

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  • P2.01-82 Lung Cancer in Lung Transplant Recipients

    S. Otani, T. Shiotani, K. Suzawa, K. Miyoshi, H. Yamamoto, M. Okazaki, S. Sugimoto, M. Yamane, T. Oto, S. Toyooka

    Journal of Thoracic Oncology   14 ( 10 )   2019.10

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    DOI: 10.1016/j.jtho.2019.08.1425

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  • MA20.11 Surgical Treatment for Metastatic Lung Tumors from Sarcomas of Soft Tissue and Bone

    H. Yamamoto, K. Namba, H. Yamamoto, T. Toji, J. Soh, K. Shien, K. Suzawa, T. Kurosaki, S. Ohtani, M. Okazaki, S. Sugimoto, M. Yamane, K. Takahashi, T. Kunisada, T. Oto, S. Toyooka

    Journal of Thoracic Oncology   14 ( 10 )   2019.10

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    DOI: 10.1016/j.jtho.2019.08.672

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  • EP1.01-18 Clinical Features of Locally Advanced Lung Cancer Patients with Radiation Pneumonitis After Induction Chemoradiotherapy

    K. Araki, K. Suzawa, S. Miyauchi, A. Miura, K. Namba, S. Otani, H. Yamamoto, M. Okazaki, S. Sugimoto, M. Yamane, S. Toyooka

    Journal of Thoracic Oncology   14 ( 10 )   2019.10

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    DOI: 10.1016/j.jtho.2019.08.1994

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  • P2.18-12 Prognostic Nutrition Index Affects Prognosis of Trimodality Therapy for Locally Advanced Lung Cancer with High T Factor

    J. Soh, K. Suzawa, K. Shien, S. Otani, H. Yamamoto, M. Okazaki, S. Sugimoto, M. Yamane, T. Oto, K. Kiura, S. Toyooka

    Journal of Thoracic Oncology   14 ( 10 )   2019.10

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    DOI: 10.1016/j.jtho.2019.08.1966

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  • P1.16-35 The Prognostic Impact of Sarcopenia on the Clinical Outcome of Thoracic Surgery for Non-Small Cell Lung Cancer in Elderly Patients

    A. Miura, J. Soh, S. Miyauchi, K. Araki, K. Nakata, K. Namba, K. Suzawa, S. Otani, H. Yamamoto, M. Okazaki, S. Sugimoto, M. Yamane, S. Toyooka

    Journal of Thoracic Oncology   14 ( 10 )   2019.10

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    DOI: 10.1016/j.jtho.2019.08.1261

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  • ハイリスク症例に対する肺移植 高度の胸膜癒着を認めたレシピエントに対する肺移植 Reviewed

    杉本 誠一郎, 塩谷 俊雄, 山本 治慎, 大河 知世, 三好 健太郎, 大谷 真二, 岡崎 幹生, 山根 正修, 大藤 剛宏, 豊岡 伸一

    移植   54 ( 総会臨時 )   174 - 174   2019.9

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  • ドナー胸腔内所見により再斡旋によるレシピエント変更後に肺移植を行った1例 Reviewed

    松原 慧, 大谷 真二, 山本 治慎, 塩谷 俊雄, 難波 圭, 二萬 英斗, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    移植   54 ( 総会臨時 )   315 - 315   2019.9

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  • 生体・脳死肺移植における予後予測因子としてのPrognostic Nutrition Index(PNI)の有用性 Reviewed

    山本 治慎, 杉本 誠一郎, 塩谷 俊雄, 三好 健太郎, 大谷 真二, 岡崎 幹生, 山根 正修, 大藤 剛宏, 豊岡 伸一

    移植   54 ( 総会臨時 )   215 - 215   2019.9

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  • 肺移植後移植片慢性機能不全の予防と治療-本邦における肺移植開始後20年での現状- 肺移植後移植片慢性機能不全(CLAD)における血中micro-RNA発現量の検討 Reviewed

    塩谷 俊雄, 杉本 誠一郎, 松原 慧, 山本 治慎, 二萬 英斗, 三好 健太郎, 大谷 真二, 岡崎 幹生, 山根 正修, 大藤 剛宏, 豊岡 伸一

    移植   54 ( 総会臨時 )   189 - 189   2019.9

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  • 患側の同定に難渋した食道癌術後に発症した両側気胸症例

    村田光隆, 諏澤 憲, 岡﨑幹生, 高津史明, 塩谷 俊雄, 三好 健太郎, 大谷真二, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 豊岡伸一

    第94回中国四国外科学会総会   2019.9

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  • ドナー胸腔内所見により再斡旋によるレシピエント変更後に肺移植を行った1例

    松原 慧, 大谷 真二, 山本 治慎, 塩谷 俊雄, 難波 圭, 二萬 英斗, 諏澤 憲, 三好 健太郎, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    移植   54 ( 総会臨時 )   315 - 315   2019.9

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  • 肺移植後移植片慢性機能不全の予防と治療-本邦における肺移植開始後20年での現状- 肺移植後移植片慢性機能不全(CLAD)における血中micro-RNA発現量の検討

    塩谷 俊雄, 杉本 誠一郎, 松原 慧, 山本 治慎, 二萬 英斗, 三好 健太郎, 大谷 真二, 岡崎 幹生, 山根 正修, 大藤 剛宏, 豊岡 伸一

    移植   54 ( 総会臨時 )   189 - 189   2019.9

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  • ハイリスク症例に対する肺移植 高度の胸膜癒着を認めたレシピエントに対する肺移植

    杉本 誠一郎, 塩谷 俊雄, 山本 治慎, 大河 知世, 三好 健太郎, 大谷 真二, 岡崎 幹生, 山根 正修, 大藤 剛宏, 豊岡 伸一

    移植   54 ( 総会臨時 )   174 - 174   2019.9

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  • 生体・脳死肺移植における予後予測因子としてのPrognostic Nutrition Index(PNI)の有用性

    山本 治慎, 杉本 誠一郎, 塩谷 俊雄, 三好 健太郎, 大谷 真二, 岡崎 幹生, 山根 正修, 大藤 剛宏, 豊岡 伸一

    移植   54 ( 総会臨時 )   215 - 215   2019.9

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  • 災害ボランティア活動に参加した喘息患者の血痰精査中に発見された右胸部異常陰影の一例

    鹿谷 芳伸, 黒崎 毅史, 大谷 真二, 中田 憲太郎, 難波 圭, 諏澤 憲, 枝園 和彦, 久保 寿夫, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 宗 淳一, 山根 正修, 大藤 剛宏, 豊岡 伸一

    岡山医学会雑誌   131 ( 2 )   113 - 113   2019.8

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  • 肺癌根治術後の同側肺癌症例に対する肺葉切除術または残肺全摘術の治療成績

    岡崎 幹生, 宗淳一, 黒崎毅史, 枝園和彦, 大谷真二, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 豊岡伸一

    第62回関西胸部外科学会学術集会   2019.6

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  • 導入療法後手術を行った局所進行肺がんの晩期に発症した肺アスペルギルス症に対して残肺全摘術を行った1例

    中田憲太郎, 山本寛斉, 宗淳一, 黒崎毅史, 枝園和彦, 大谷真二, 岡﨑幹生, 杉本誠一郎, 山根正修, 大藤剛宏, 豊岡伸一

    第62回関西胸部外科学会学術集会   2019.6

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  • 両側生体肺移植後のChronic Lung Allograft Dysfunctionの早期診断 肺血流シンチグラフィーの可能性

    山本 治慎, 杉本 誠一郎, 黒崎 毅史, 大谷 真二, 岡崎 幹生, 山根 正修, 豊岡 伸一, 大藤 剛宏

    日本呼吸器外科学会雑誌   33 ( 3 )   P96 - 2   2019.4

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  • 手掌多汗症に対する胸腔鏡下胸部交感神経交通枝切離術の手術成績

    黒崎 毅史, 森山 重治, 葉山 牧夫, 枝園 和彦, 大谷 真二, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 宗 淳一, 山根 正修, 大藤 剛宏, 豊岡 伸一

    日本呼吸器外科学会雑誌   33 ( 3 )   RV6 - 5   2019.4

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  • 保険診療に向けた肺癌に対するロボット支援手術の導入

    岡崎 幹生, 枝園 和彦, 黒崎 毅史, 大谷 真二, 山本 寛斉, 杉本 誠一郎, 宗 淳一, 山根 正修, 大藤 剛宏, 豊岡 伸一

    日本呼吸器外科学会雑誌   33 ( 3 )   P17 - 7   2019.4

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  • 生体肺移植後慢性拒絶反応と血中Irisin濃度の関係

    塩谷 俊雄, 杉本 誠一郎, 山本 治慎, 黒崎 毅史, 枝園 和彦, 大谷 真二, 山本 寛斉, 岡崎 幹生, 宗 淳一, 山根 正修, 大藤 剛宏, 豊岡 伸一

    日本呼吸器外科学会雑誌   33 ( 3 )   RO11 - 1   2019.4

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  • 術前放射線同時併用化学療法後手術を行った局所進行肺癌の術後再発に対する治療戦略 局所治療の有用性

    諏澤 憲, 宗 淳一, 枝園 和彦, 黒崎 毅史, 大谷 真二, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    日本呼吸器外科学会雑誌   33 ( 3 )   RO12 - 2   2019.4

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  • MET exon 14スキッピング変異肺癌に対する治療戦略 薬剤耐性克服を目指して

    諏澤 憲, 枝園 和彦, 山本 寛斉, 宗 淳一, 黒崎 毅史, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, ソムワー・ロメル, ラダニー・マーク, 豊岡 伸一

    日本呼吸器外科学会雑誌   33 ( 3 )   RO2 - 4   2019.4

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  • ラジオ波焼灼療法を契機に発症した肺膿瘍と膿胸に対する段階的手術の経験

    中田 憲太郎, 杉本 誠一郎, 鹿谷 芳伸, 黒崎 毅史, 枝園 和彦, 大谷 真二, 山本 寛斉, 宗 淳一, 山根 正修, 大藤 剛宏, 豊岡 伸一

    日本呼吸器外科学会雑誌   33 ( 3 )   RO8 - 4   2019.4

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  • 呼吸器感染症の外科治療 感染性肺疾患に対する肺移植の長期成績

    杉本 誠一郎, 黒崎 毅史, 大谷 真二, 枝園 和彦, 山本 寛斉, 岡崎 幹生, 宗 淳一, 山根 正修, 豊岡 伸一, 大藤 剛宏

    日本呼吸器外科学会雑誌   33 ( 3 )   WS4 - 5   2019.4

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  • 局所進行悪性胸部腫瘍に対する拡大手術 中枢進行型肺癌における自家肺移植(the Oto procedure)の長期成績

    塩谷 俊雄, 大谷 真二, 田中 真, 黒崎 毅史, 枝園 和彦, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 宗 淳一, 山根 正修, 豊岡 伸一, 大藤 剛宏

    日本呼吸器外科学会雑誌   33 ( 3 )   PD2 - 8   2019.4

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  • 呼吸器以外の併存疾患を有する症例および高齢者肺癌の周術期管理 高齢者肺癌に対する多職種連携周術期管理による術後合併症減少の試み

    三浦 章博, 宗 淳一, 宮内 俊策, 荒木 恒太, 中田 憲太郎, 塩谷 俊雄, 高橋 優太, 黒崎 毅史, 諏澤 憲, 枝園 和彦, 大谷 真二, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    日本呼吸器外科学会雑誌   33 ( 3 )   PD3 - 7   2019.4

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  • 肺移植へのゲノム医療の応用

    杉本 誠一郎, 山本 治慎, 田中 真, 諏澤 憲, 黒崎 毅史, 枝園 和彦, 大谷 真二, 山本 寛斉, 岡崎 幹生, 宗 淳一, 山根 正修, 大藤 剛宏, 豊岡 伸一

    日本外科学会定期学術集会抄録集   119回   SF - 036   2019.4

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  • 呼吸器外科医専門医としてあるべき姿を認定する専門医制度を目指す

    山根 正修, 杉本 誠一郎, 豊岡 伸一

    日本呼吸器外科学会雑誌   33 ( 3 )   SS2 - 6   2019.4

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  • 呼吸器外科医によるトランスレーショナルリサーチ トランスレーショナル研究の経験

    豊岡 伸一, 枝園 和彦, 山本 寛斉, 宗 淳一, 黒崎 毅史, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏

    日本外科学会定期学術集会抄録集   119回   WS - 8   2019.4

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  • 肉腫多発肺転移に対する肺切除術

    山本 寛斉, 枝園 和彦, 宗 淳一, 黒崎 毅史, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    日本呼吸器外科学会雑誌   33 ( 3 )   RO20 - 1   2019.4

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  • Decreased Serum Levels of Irisin are Associated with the Development of Chronic Lung Allograft Dysfunction after Bilateral Living-Donor Lobar Lung Transplantation

    T. Shiotani, S. Sugimoto, H. Yamamoto, T. Kurosaki, S. Otani, M. Okazaki, M. Yamane, S. Toyooka, T. Oto

    The Journal of Heart and Lung Transplantation   38 ( 4 )   S406 - S407   2019.4

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    DOI: 10.1016/j.healun.2019.01.1036

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  • Differences in Onset of Chronic Lung Allograft Dysfunction between Living Donor and Cadaveric Lung Transplantation

    S. Sugimoto, H. Yamamoto, T. Kurosaki, S. Otani, M. Okazaki, M. Yamane, S. Toyooka, T. Oto

    The Journal of Heart and Lung Transplantation   38 ( 4 )   2019.4

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    DOI: 10.1016/j.healun.2019.01.1041

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  • Early Shift of Lung Perfusion to the Unilateral Lung Predicts the Development of Unilateral Chronic Lung Allograft Dysfunction after Bilateral Living-Donor Lobar Lung Transplantation

    H. Yamamoto, S. Sugimoto, T. Kurosaki, S. Otani, M. Okazaki, M. Yamane, S. Toyooka, T. Oto

    The Journal of Heart and Lung Transplantation   38 ( 4 )   S408 - S409   2019.4

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    DOI: 10.1016/j.healun.2019.01.1040

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  • New Technique Which Was Combined Living Donor Lower Lobe with Cadaveric Marginal Lung as Called “Hybrid Lung Transplant”

    T. Kurosaki, S. Otani, K. Miyoshi, M. Okazaki, S. Sugimoto, M. Yamane, T. Oto

    The Journal of Heart and Lung Transplantation   38 ( 4 )   S337 - S338   2019.4

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    DOI: 10.1016/j.healun.2019.01.853

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  • Inverted Lung Transplantation: Interposition of Pericardial Conduit for Pulmonary Venous Anastomosis

    H. Yamamoto, K. Miyoshi, T. Kurosaki, S. Otani, M. Okazaki, S. Sugimoto, M. Yamane, S. Toyooka, T. Oto

    The Journal of Heart and Lung Transplantation   38 ( 4 )   2019.4

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    DOI: 10.1016/j.healun.2019.01.077

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  • 同種骨髄移植後に難治性気胸を呈し,脳死両肺移植を施行した二次性pleuroparenchymal fibroelastosis(PPFE)の1例

    谷本 安, 細川 忍, 肥後 寿夫, 杉本 誠一郎, 別所 昭宏, 大藤 剛宏, 木浦 勝行, 山鳥 一郎

    日本呼吸器学会誌   8 ( 増刊 )   320 - 320   2019.3

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  • EGFR遺伝子検索が診断・治療の一助となった両側同時多発肺腺癌の1例

    梅田 将志, 山本 寛斉, 中田 憲太郎, 枝園 和彦, 宗 淳一, 黒崎 毅史, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    肺癌   59 ( 1 )   99 - 99   2019.2

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  • 左上葉切除術後6日目に診断しえた左上肺静脈断端血栓の1例

    本田 貴裕, 杉本 誠一郎, 鹿谷 芳伸, 枝園 和彦, 山本 寛斉, 岡崎 幹生, 宗 淳一, 山根 正修, 豊岡 伸一, 黒崎 毅史, 大谷 真二, 大藤 剛宏

    肺癌   59 ( 1 )   107 - 108   2019.2

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  • 左上葉切除術後6日目に診断しえた左上肺静脈断端血栓の1例

    本田貴裕, 杉本誠一郎, 鹿谷芳伸, 枝園和彦, 山本寛斉, 岡崎幹生, 宗淳一, 山根正修, 豊岡伸一, 黒崎毅史, 大谷真二, 大藤剛宏

    肺癌(Web)   59 ( 1 )   2019

  • EGFR遺伝子検索が診断・治療の一助となった両側同時多発肺腺癌の1例

    梅田将志, 山本寛斉, 中田憲太郎, 枝園和彦, 宗淳一, 黒崎毅史, 大谷真二, 岡崎幹生, 杉本誠一郎, 山根正修, 大藤剛宏, 豊岡伸一

    肺癌(Web)   59 ( 1 )   2019

  • SPECT/CTを用いて切除範囲を評価した左肺底動脈大動脈起始症の1例

    山本諒, 杉本誠一郎, 中田憲太郎, 塩谷俊雄, 三好健太郎, 大谷真二, 山本寛斉, 岡崎幹生, 山根正修, 大藤剛宏, 豊岡伸一, 末澤孝徳

    肺癌(Web)   59 ( 5 )   2019

  • 同種骨髄移植後に難治性気胸を呈し,脳死両肺移植を施行した二次性pleuroparenchymal fibroelastosis(PPFE)の1例

    谷本安, 細川忍, 肥後寿夫, 杉本誠一郎, 別所昭宏, 大藤剛宏, 木浦勝行, 山鳥一郎

    日本呼吸器学会誌(Web)   8   2019

  • 本邦初の生体肺移植症例の移植後20年の経過

    小松雅宙, 山本洋, 市山崇史, 牛木淳人, 安尾将法, 小泉知展, 杉本誠一郎, 大藤剛宏, 伊達洋至, 花岡正幸

    日本呼吸器学会誌(Web)   8   2019

  • 縦隔炎合併前縦隔腫瘍の1例

    三浦 章博, 枝園 和彦, 黒崎 毅史, 大谷 真二, 山本 寛斉, 岡崎 幹夫, 杉本 誠一郎, 宗 淳一, 山根 正修, 大藤 剛宏, 豊岡 伸一

    岡山医学会雑誌   130 ( 3 )   185 - 185   2018.12

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  • 導入化学放射線療法後手術を施行した局所進行非小細胞肺癌患者に発症した肺アスペルギルス症

    杉本 誠一郎, 宗 淳一, 枝園 和彦, 黒崎 毅史, 大谷 真二, 山本 寛斉, 岡崎 幹生, 山根 正修, 大藤 剛宏, 木浦 勝行, 金澤 右, 豊岡 伸一

    肺癌   58 ( 6 )   569 - 569   2018.10

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  • 右上葉スリーブ切除を施行した気管支原発粘液腫の1例

    二萬 英斗, 三好 健太郎, 黒崎 毅史, 枝園 和彦, 大谷 真二, 杉本 誠一郎, 宗 淳一, 山根 正修, 大藤 剛宏, 豊岡 伸一

    肺癌   58 ( 6 )   619 - 619   2018.10

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  • 免疫療法の新展開 悪性胸膜中皮腫に対するREIC/Dkk-3遺伝子治療

    山本 寛斉, 枝園 和彦, 宗 淳一, 黒崎 毅史, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    肺癌   58 ( 6 )   441 - 441   2018.10

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  • 局所進行非小細胞肺癌に対する導入療法後肺切除術の晩期肺障害を考える

    宗 淳一, 杉本 誠一郎, 枝園 和彦, 山本 寛斉, 黒崎 毅史, 大谷 真二, 岡崎 幹生, 山根 正修, 勝井 邦彰, 大藤 剛宏, 木浦 勝行, 金澤 右, 豊岡 伸一

    肺癌   58 ( 6 )   567 - 567   2018.10

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  • 肺移植後に発見された肺癌の検討

    大谷 真二, 黒崎 毅史, 枝園 和彦, 山本 寛斉, 岡崎 幹生, 杉本 誠一郎, 宗 淳一, 豊岡 伸一, 大藤 剛宏

    肺癌   58 ( 6 )   526 - 526   2018.10

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  • P3.CR-07 Comprehensive Genomic Profiles for a Mediastinal Tumor Suspected of Synovial Sarcoma: A Case Report

    K. Araki, K. Shien, K. Namba, J. Soh, S. Miyauchi, A. Miura, Y. Takahashi, E. Kurihara, Y. Ogoshi, H. Yamamoto, S. Sugimoto, M. Yamane, S. Toyooka

    Journal of Thoracic Oncology   13 ( 10 )   2018.10

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    DOI: 10.1016/j.jtho.2018.08.1986

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  • P2.01-71 Clinical Outcome of Induction Chemoradiotherapy Followed by Surgery for the Patients with cN2 Non-Small Cell Lung Cancer

    A. Miura, J. Soh, K. Araki, Y. Takahashi, E. Kurihara, Y. Ogoshi, K. Shien, H. Yamamoto, S. Sugimoto, M. Yamane, K. Kiura, S. Kanazawa, S. Toyooka

    Journal of Thoracic Oncology   13 ( 10 )   2018.10

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    DOI: 10.1016/j.jtho.2018.08.1125

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  • P1.17-15 Perioperative Prognostic Nutrition Index for Induction Chemoradiotherapy Followed by Surgery in Locally Advanced Non-Small Lung Cancers

    J. Soh, S. Miyauchi, K. Araki, A. Miura, Y. Takahashi, E. Kurihara, Y. Ogoshi, K. Shien, H. Yamamoto, S. Sugimoto, M. Yamane, K. Kiura, S. Kanazawa, S. Toyooka

    Journal of Thoracic Oncology   13 ( 10 )   2018.10

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    DOI: 10.1016/j.jtho.2018.08.1048

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  • P1.14-29 Surgical Treatment for Metastatic Lung Tumors from Various Sarcomas

    H. Yamamoto, K. Namba, K. Takahashi, J. Soh, K. Shien, T. Kurosaki, S. Ohtani, M. Okazaki, S. Sugimoto, M. Yamane, T. Oto, S. Toyooka

    Journal of Thoracic Oncology   13 ( 10 )   2018.10

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    DOI: 10.1016/j.jtho.2018.08.931

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  • P1.14-30 Prognostic Factors for Sarcoma Patients with Lung Metastasis Who Underwent Extended Pulmonary Resection

    H. Yamamoto, K. Namba, H. Yamamoto, J. Soh, K. Shien, T. Kurosaki, S. Ohtani, M. Okazaki, S. Sugimoto, M. Yamane, T. Oto, S. Toyooka

    Journal of Thoracic Oncology   13 ( 10 )   S610 - S611   2018.10

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    DOI: 10.1016/j.jtho.2018.08.932

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  • P1.17-17 The Impact of Induction Chemoradiotherapy Followed by Surgery for N1 Involved Non-Small Cell Lung Cancer

    Y. Takahashi, J. Soh, S. Miyauchi, K. Araki, A. Miura, E. Kurihara, Y. Ogoshi, K. Shien, H. Yamamoto, S. Sugimoto, M. Yamane, K. Kiura, S. Kanazawa, S. Toyooka

    Journal of Thoracic Oncology   13 ( 10 )   2018.10

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    DOI: 10.1016/j.jtho.2018.08.1050

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  • P3.01-72 Pulmonary Resection in a Prone Position for Lung Cancer Invading the Spine: Two Cases Report

    S. Miyauchi, J. Soh, K. Araki, A. Miura, Y. Takahashi, E. Kurihara, Y. Ogoshi, K. Shien, H. Yamamoto, S. Sugimoto, M. Yamane, S. Toyooka

    Journal of Thoracic Oncology   13 ( 10 )   2018.10

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    DOI: 10.1016/j.jtho.2018.08.1632

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  • 気管支吻合部合併症ゼロを目指して

    黒崎毅史, 大谷真二, 杉本誠一郎, 山本治慎, 塩谷俊雄, 鹿谷芳伸, 田中真, 橋本好平, 二萬英斗, 岡崎幹生, 山根正修, 大藤剛宏

    日本移植学会総会プログラム抄録集   53 ( 総会臨時 )   248 - 248   2018.9

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  • 両側生体肺移植後のCLAD診断における肺血流シンチグラフィーの有用性

    山本治慎, 杉本誠一郎, 黒崎毅史, 大谷真二, 岡崎幹生, 山根正修, 豊岡伸一, 大藤剛宏

    日本移植学会総会プログラム抄録集   54th ( 総会臨時 )   343 - 343   2018.9

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  • 肺移植待機IIPs患者におけるピルフェニドン治療介入が待機許容に与える影響について

    三好健太郎, 田中真, 黒崎毅史, 大谷真二, 杉本誠一郎, 山根正修, 豊岡伸一, 大藤剛宏

    日本移植学会総会プログラム抄録集   54th   398   2018.9

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  • 術前ステロイド投与が造血幹細胞移植後の肺移植に与える影響

    杉本誠一郎, 黒崎毅史, 大谷真二, 岡崎幹生, 山根正修, 豊岡伸一, 大藤剛宏

    日本移植学会総会プログラム抄録集   54th ( 総会臨時 )   278 - 278   2018.9

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  • 本邦の肺移植医療における呼吸器内科医の関与の仕方

    大谷真二, 黒崎毅史, 肥後寿夫, 大河知世, 岡崎幹生, 杉本誠一郎, 山根正修, 大藤剛宏

    日本移植学会総会プログラム抄録集   54th   231   2018.9

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  • 骨髄異形成症候群を合併した若年者自然気胸に対する再発予防手術の適応

    塩谷俊雄, 黒崎毅史, 枝園和彦, 大谷真二, 山本寛斉, 杉本誠一郎, 宗淳一, 山根正修, 大藤剛宏, 豊岡伸一

    日本気胸・嚢胞性肺疾患学会雑誌   18 ( 2 )   109 - 109   2018.7

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  • 嚢胞性肺疾患に対する片肺移植後に残存自己肺に生じる合併症

    二萬英斗, 黒崎毅史, 大谷真二, 杉本誠一郎, 山根正修, 豊岡伸一, 大藤剛宏

    日本気胸・嚢胞性肺疾患学会雑誌   18 ( 2 )   85   2018.7

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  • 岡山大学病院におけるリンパ脈管筋腫症(LAM)と肺移植の現状

    黒崎毅史, 黒崎毅史, 大谷真二, 大谷真二, 杉本誠一郎, 山根正修, 豊岡伸一, 大藤剛宏

    日本気胸・嚢胞性肺疾患学会雑誌   18 ( 2 )   85   2018.7

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  • 悪性胸膜中皮腫に対するREIC/Dkk-3遺伝子治療

    山本 寛斉, 諏澤 憲, 枝園 和彦, 宗 淳一, 黒崎 毅史, 大谷 真二, 岡崎 幹生, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    日本がん免疫学会総会プログラム・抄録集   22回   146 - 146   2018.7

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  • 上縦隔に発生した肺葉外肺分画症の1例

    三浦章博, 大谷真二, 林直宏, 荒木恒太, 宮内俊策, 塩谷俊雄, 黒崎毅史, 枝園和彦, 山本寛斉, 杉本誠一郎, 宗淳一, 山根正修, 大藤剛宏, 豊岡伸一

    日本臨床外科学会雑誌   79 ( 6 )   1340 - 1340   2018.6

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  • 脳死両側肺葉移植後に胸骨ワイヤーの皮下への迷入を認めた1例

    林直宏, 三浦章博, 山本治慎, 黒崎毅史, 枝園和彦, 大谷真二, 山本寛斉, 杉本誠一郎, 宗淳一, 山根正修, 豊岡伸一, 大藤剛宏

    日本臨床外科学会雑誌   79 ( 6 )   1340 - 1340   2018.6

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  • 日本における肺移植の現状

    黒崎毅史, 大谷真二, 田中真, 山本治慎, 鹿谷芳伸, 二萬英斗, 目崎久美, 塩谷俊雄, 荒木恒太, 宮原一彰, 橋本好平, 杉本誠一郎, 山根正修, 豊岡伸一, 大藤剛宏

    日本呼吸器外科学会総会(Web)   32 ( 3 )   PD1 - 8   2018.4

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  • The Feasibility of Lung Transplantation From Donors Mechanically Ventilated for Prolonged Periods

    Seiichiro Sugimoto

    The Journal of Heart and Lung Transplantation   2018.4

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  • Experience of Using mTOR Inhibitor in Lung Transplant at Recipients With Lymphangioleiomyomatosis

    T. Kurosaki, S. Otani, S. Sugimoto, K. Miyoshi, H. Yamamoto, S. Tanaka, Y. Shikatani, K. Mesaki, K. Hashimoto, M. Yamane, S. Toyooka, T. Oto

    The Journal of Heart and Lung Transplantation   37 ( 4 )   S455 - S456   2018.4

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    DOI: 10.1016/j.healun.2018.01.1186

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  • Early Detection of Chronic Lung Allograft Dysfunction After Bilateral Living Donor Lobar Lung Transplantation by Computed Tomographic Scanning Scoring Method

    E. Niman, K. Miyoshi, S. Namura, T. Kurosaki, S. Ohtani, S. Sugimoto, M. Yamane, S. Toyooka, T. Oto

    The Journal of Heart and Lung Transplantation   37 ( 4 )   2018.4

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    DOI: 10.1016/j.healun.2018.01.1152

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  • Overexpression of SOCS3 Attenuates Tracheal Allograft Rejection in the Early Phase After Murine Heterotopic Tracheal Transplantation by the Inhibition of Th1 Response

    K. Mesaki, S. Sugimoto, H. Watanabe, M. Fujisawa, T. Yoshimura, T. Kurosaki, S. Otani, M. Yamane, S. Toyooka, A. Matsukawa, T. Oto

    The Journal of Heart and Lung Transplantation   37 ( 4 )   2018.4

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    DOI: 10.1016/j.healun.2018.01.509

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  • Increased Plasma Levels of Donor-derived Cell-free DNA Correlate With Acute Rejection in the Recipients of Living Donor-lobar Lung Transplantation

    S. Tanaka, S. Sugimoto, T. Kurosaki, S. Otani, M. Yamane, S. Toyooka, T. Oto

    The Journal of Heart and Lung Transplantation   37 ( 4 )   2018.4

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    DOI: 10.1016/j.healun.2018.01.570

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  • Spred-2 is Necessary to Protect Against Lung Graft Injury After Mouse Lung Transplantation

    K. Hashimoto, S. Sugimoto, T. Kurosaki, S. Otani, M. Yamane, S. Toyooka, T. Oto

    The Journal of Heart and Lung Transplantation   37 ( 4 )   S212 - S213   2018.4

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    DOI: 10.1016/j.healun.2018.01.520

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  • 肺移植後気管支合併症は脳死肺移植より生体肺移植の予後に大きな影響を与える

    杉本誠一郎, 山根正修, 黒崎毅史, 大谷真二, 枝園和彦, 山本寛斉, 宗淳一, 豊岡伸一, 大藤剛宏

    日本呼吸器外科学会総会(Web)   35th ( 3 )   ROMBUNNO.RO17‐6 (WEB ONLY) - 6   2018

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  • 小児肺移植における術中・術後管理

    塩谷俊雄, 塩谷俊雄, 大谷真二, 大谷真二, 黒崎毅史, 黒崎毅史, 岡原修二, 岡原修二, 日笠友起子, 日笠友起子, 小林求, 小林求, 杉本誠一郎, 杉本誠一郎, 山根正修, 山根正修, 大藤剛宏, 大藤剛宏

    日本肺および心肺移植研究会プログラム・抄録集   34th   39   2018

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  • cN2非小細胞肺癌に対する術前導入療法後手術の治療成績の検討~治療後再発因子に注目して~

    三浦章博, 宗淳一, 黒崎毅史, 枝園和彦, 大谷真二, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 豊岡伸一

    日本呼吸器外科学会総会(Web)   35th ( 3 )   ROMBUNNO.RO11‐4 (WEB ONLY) - 4   2018

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  • 妊婦に合併した縦隔成熟奇形腫に対して手術を行った1例

    宮内俊策, 枝園和彦, 宗淳一, 黒崎毅史, 大谷真二, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 豊岡伸一

    日本呼吸器外科学会総会(Web)   35th ( 3 )   ROMBUNNO.P64‐4 (WEB ONLY) - 4   2018

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  • cN1非小細胞肺癌に対する術前化学放射線療法後手術の可能性

    高橋優太, 宗淳一, 黒崎毅史, 枝園和彦, 大谷真二, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 豊岡伸一

    日本呼吸器外科学会総会(Web)   35th ( 3 )   ROMBUNNO.O6‐2 (WEB ONLY) - 2   2018

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  • 肺移植後の肺機能にグルココルチコイド感受性遺伝子が与える影響

    山本治慎, 杉本誠一郎, 田中真, 黒崎毅史, 大谷真二, 山根正修, 豊岡伸一, 大藤剛宏

    日本呼吸器外科学会総会(Web)   35th   ROMBUNNO.RO8‐2 (WEB ONLY)   2018

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  • 心臓手術後急性期の脳死ドナーにおける脳死下肺摘出術の留意点癒着が予想される肺ドナーにおけるハーベストの留意点

    黒崎毅史, 杉本誠一郎, 鹿谷芳伸, 橋本好平, 目崎久美, 田中真, 二萬英斗, 大谷真二, 山根正修, 豊岡伸一, 大藤剛宏

    日本肺および心肺移植研究会プログラム・抄録集   34th   40   2018

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  • ベトナム初の肺移植成功

    田中真, 大谷真二, 山本治慎, 鹿谷芳伸, 目崎久美, 橋本好平, 宮原一彰, 二萬英斗, 黒崎毅史, 杉本誠一郎, 山根正修, 岡原修司, 日笠友起子, 小林求, 大藤剛宏

    日本肺および心肺移植研究会プログラム・抄録集   34th   31   2018

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  • 異なる癌腫におけるHER2膜貫通領域の遺伝子変異の同定と最適化治療

    山本寛斉, 枝園和彦, 宗淳一, 黒崎毅史, 大谷真二, 杉本誠一郎, 山根正修, 大藤剛宏, 豊岡伸一

    日本外科学会定期学術集会(Web)   118th   ROMBUNNO.PS‐136‐1 (WEB ONLY) - 2157   2018

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  • Superior sulcus tumorに対するtransmanubrial approachとVATSを組み合わせた仰臥位での左肺上葉切除

    塩谷俊雄, 枝園和彦, 宗淳一, 黒崎毅史, 大谷真二, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 豊岡伸一

    日本呼吸器外科学会総会(Web)   35th ( 3 )   ROMBUNNO.V15‐2 (WEB ONLY) - 2   2018

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  • 海水溺水による脳死ドナーの両肺上葉を利用した脳死左片肺移植の1例

    鹿谷芳伸, 大谷真二, 橋本好平, 目崎久美, 田中真, 二萬英斗, 黒崎毅史, 杉本誠一郎, 山根正修, 大藤剛宏

    日本肺および心肺移植研究会プログラム・抄録集   34th   22   2018

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  • アニマルラボを利用した胸部外科手術におけるチームトレーニング

    山根正修, 杉本誠一郎, 宗淳一, 豊岡伸一

    日本呼吸器外科学会総会(Web)   35th ( 3 )   ROMBUNNO.P78‐2 (WEB ONLY) - 2   2018

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  • 局所進行非小細胞肺癌に対する化学放射線療法後の心大血管合併切除手術

    宗淳一, 佐藤博紀, 難波圭, 鳥越英次郎, 黒崎毅史, 枝園和彦, 大谷真二, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 豊岡伸一

    日本外科学会定期学術集会(Web)   118th   ROMBUNNO.SS‐5‐6 (WEB ONLY) - 348   2018

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  • 移植肺由来血中遊離DNAは生体肺移植後のPrimary graft dysfunctionや急性拒絶反応に関連する

    田中真, 杉本誠一郎, 黒崎毅史, 大谷真二, 山根正修, 豊岡伸一, 大藤剛宏

    日本呼吸器外科学会総会(Web)   35th   ROMBUNNO.RO8‐1 (WEB ONLY)   2018

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  • 外科技術の継承の試み~継承向上と手術手技トレーニングの実践

    山根正修, 万代康弘, 野間和広, 杉本誠一郎, 伊野英男, 太田徹哉, 田中信一郎, 村岡篤, 片岡正文, 信久徹治, 笠原真悟, 豊岡伸一, 藤原俊義

    日本外科学会定期学術集会(Web)   118th   ROMBUNNO.SF‐022‐4 (WEB ONLY)   2018

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  • Sproutry-related EVH1-domain-containing protein(Spred2)の急性期虚血再還流障害における移植肺への影響

    橋本好平, 杉本誠一郎, 黒崎毅, 大谷真二, 山根正修, 豊岡伸一, 大藤剛宏

    日本胸部外科学会定期学術集会(Web)   71st   2018

  • 肉腫多発肺転移に対する肺切除術の検討

    山本寛斉, 難波圭, 枝園和彦, 宗淳一, 黒崎毅史, 大谷真二, 岡崎幹生, 杉本誠一郎, 山根正修, 大藤剛宏, 豊岡伸一

    日本胸部外科学会定期学術集会(Web)   71st   2018

  • 診断および周術期管理に苦慮した縦隔炎合併胸腺嚢胞の1例

    高橋 洋祐, 枝園 和彦, 宗 淳一, 栗原 英祐, 大谷 真二, 山本 寛斉, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 豊岡 伸一

    肺癌   57 ( 7 )   907 - 907   2017.12

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  • P2.16-026 Surgical Treatment for Metastatic Lung Tumors from Various Sarcomas

    H. Yamamoto, K. Namba, K. Takahashi, J. Soh, K. Shien, T. Kurosaki, S. Ohtani, S. Sugimoto, M. Yamane, T. Oto, S. Toyooka

    Journal of Thoracic Oncology   12 ( 11 )   2017.11

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    DOI: 10.1016/j.jtho.2017.09.1435

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  • 肉腫多発肺転移に対する肺切除術の検討

    山本寛斉, 難波圭, 枝園和彦, 宗淳一, 大谷真二, 杉本誠一郎, 大藤剛宏, 豊岡伸一

    日本臨床外科学会雑誌   78 ( 増刊 )   412 - 412   2017.10

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  • G‐CSF投与による増悪が示唆された肺癌術後壊疽性膿皮症の1例

    山本治慎, 杉本誠一郎, 大谷真二, 黒崎毅史, 枝園和彦, 山本寛斉, 宗淳一, 山根正修, 豊岡伸一, 大藤剛宏

    日本肺癌学会総会号   58th ( 5 )   497 - 497   2017.9

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  • 椎体浸潤局所進行肺癌に対する腹臥位アプローチによる根治切除術

    宗淳一, 豊岡伸一, 黒崎毅史, 大谷真二, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 金澤右, 木浦勝行

    日本肺癌学会総会号   58th ( 5 )   403 - 403   2017.9

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  • 肉腫多発肺転移に対する肺切除術の検討

    山本寛斉, 豊岡伸一, 枝園和彦, 宗淳一, 黒崎毅史, 大谷真二, 杉本誠一郎, 山根正修, 大藤剛宏

    日本肺癌学会総会号   58th ( 5 )   485 - 485   2017.9

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  • CTスコア法による両側生体肺移植後CLADの評価

    名村 咲音, 三好 健太郎, 黒崎 毅史, 大谷 真二, 杉本 誠一郎, 山根 正修, 三好 新一郎, 大藤 剛宏

    移植   52 ( 2-3 )   256 - 256   2017.9

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  • カルタゲナー症候群に対する脳死肺移植の経験

    山本 治慎, 杉本 誠一郎, 大谷 真二, 黒崎 毅史, 三好 健太郎, 山根 正修, 三好 新一郎, 大藤 剛宏

    移植   52 ( 2-3 )   263 - 263   2017.9

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  • 肺移植後患者に対する皮下注型グロブリン製剤の使用経験

    二萬 英斗, 三好 健太郎, 黒崎 毅史, 大谷 真二, 杉本 誠一郎, 山根 正修, 三好 新一郎, 大藤 剛宏

    移植   52 ( 2-3 )   255 - 255   2017.9

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  • 発熱・炎症反応上昇で発見された肝移植後肺硬化性血管腫の1例

    谷守通, 野田卓男, 尾山貴徳, 納所洋, 谷本光隆, 三好健太郎, 杉本誠一郎, 三好新一郎, 八木孝仁, 藤原充弘, 脇研自

    日本小児科学会雑誌   121 ( 8 )   1445‐1446 - 1446   2017.8

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  • 岡山大学病院における肺グラフト不全の原因と再肺移植

    黒崎毅史, 大谷真二, 杉本誠一郎, 大河知世, 山根正修, 大藤剛宏

    日本移植学会総会プログラム抄録集   53rd   327   2017.8

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  • 肺移植後に生体腎移植を施行した2例

    荒木恒太, 杉本誠一郎, 黒崎毅史, 大河知世, 大谷真二, 山根正修, 大藤剛宏

    日本移植学会総会プログラム抄録集   53rd   479   2017.8

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  • 肺移植後拒絶反応に対する非侵襲的バイオマーカーとしての抗HLA‐IgMの意義

    三好健太郎, 宮原一彰, 黒崎毅史, 大谷真二, 杉本誠一郎, 山根正修, 大藤剛宏

    日本移植学会総会プログラム抄録集   53rd   273   2017.8

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  • 本邦のデータに基づく造血幹細胞移植後の肺移植の検討

    陳豊史, 杉本誠一郎, 白石武史, 南正人, 松田安史, 千田雅之, 前田寿美子, 岡田克典, 奥村明之進, 岩崎昭憲, 大藤剛宏, 伊達洋至

    日本移植学会総会プログラム抄録集   53rd   348   2017.8

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  • 移植肺由来血中遊離DNAの定量による生体肺移植後の急性拒絶反応の診断

    田中真, 杉本誠一郎, 黒崎毅史, 三好健太郎, 大谷真二, 山根正修, 豊岡伸一, 大藤剛宏

    日本移植学会総会プログラム抄録集   53rd   274   2017.8

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  • Extended Criteria Donorを用いた肺移植における人工心肺の役割

    杉本誠一郎, 三好健太郎, 黒崎毅史, 大谷真二, 山根正修, 大藤剛宏

    日本移植学会総会プログラム抄録集   53rd   301   2017.8

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  • 肺移植後の慢性腎不全に対して透析を導入した症例の検討

    大谷真二, 黒崎毅史, 三好健太郎, 大河知世, 杉本誠一郎, 山根正修, 大藤剛宏

    日本移植学会総会プログラム抄録集   53rd   428   2017.8

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  • 肺移植術後Open chest managementの有用性

    塩谷俊雄, 大谷真二, 二萬英斗, 黒崎毅史, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏

    日本移植学会総会プログラム抄録集   52 ( 総会臨時 )   346 - 346   2017.8

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  • 重症慢性肺移植片対宿主病(GVHD)に対し脳死肺移植により呼吸器症状が劇的に改善した1例

    加登翔太, 半谷まゆみ, 久世崇史, 上田有里子, 三谷友一, 関正史, 樋渡光輝, 山本治慎, 大谷真二, 杉本誠一郎, 大藤剛宏, 滝田順子, 岡明

    日本小児科学会雑誌   121 ( 7 )   1239‐1240   2017.7

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  • 両側脳死肺移植後の両側気管支狭窄に対して気管支ステントを留置した1例

    大谷真二, 杉本誠一郎, 三好健太郎, 三好新一郎, 大藤剛宏

    気管支学   39   S370   2017.5

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  • G-CSF投与による増悪が示唆された肺癌術後壊疽性膿皮症の1例

    山本 治慎, 杉本 誠一郎, 大谷 真二, 黒崎 毅史, 枝園 和彦, 三好 健太郎, 山本 寛斉, 宗 淳一, 山根 正修, 豊岡 伸一, 大藤 剛宏, 三好 新一郎

    岡山医学会雑誌   129 ( 1 )   70 - 70   2017.4

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  • Pirfenidone as a Bridge Therapy for Lung Transplantation

    S. Tanaka, K. Miyoshi, T. Kurosaki, S. Otani, S. Sugimoto, M. Yamane, T. Oto

    The Journal of Heart and Lung Transplantation   36 ( 4 )   2017.4

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    DOI: 10.1016/j.healun.2017.01.1495

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  • Post-Lung Transplant Outcome & Risk Matching Between Donor & Recipient - Score-Based Analyses

    K. Miyoshi, T. Kurosaki, S. Otani, S. Sugimoto, M. Yamane, T. Oto

    The Journal of Heart and Lung Transplantation   36 ( 4 )   2017.4

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    DOI: 10.1016/j.healun.2017.01.1512

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  • Early Elevation of Anti-HLA Immunoglobulin M Level Is Associated with Subsequent Lung Transplant Rejection and Worse Outcomes

    K. Miyahara, K. Miyoshi, T. Kurosaki, S. Otani, S. Sugimoto, M. Yamane, T. Oto

    The Journal of Heart and Lung Transplantation   36 ( 4 )   2017.4

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    DOI: 10.1016/j.healun.2017.01.420

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  • Bronchial Complications After Living-Donor Lobar Lung Transplantation: Bronchial Stenoses in the Lobar to Segmental Bronchi Necessitating Earlier Intervention

    S. Sugimoto, T. Kurosaki, K. Miyoshi, S. Otani, M. Yamane, S. Miyoshi, T. Oto

    The Journal of Heart and Lung Transplantation   36 ( 4 )   S407 - S408   2017.4

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    DOI: 10.1016/j.healun.2017.01.1163

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  • Meticulous Closure of Collateral Blood Flow in the Perihilar Mediastinal Pleura Decreases Bleeding and Surgical Mortality in Lung Transplant Recipients with Pulmonary Hypertension

    Seiichiro Sugimoto

    The Journal of Heart and Lung Transplantation   2017.4

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  • Warm Retrograde Perfusion Can Remove More Fat from Lung Grafts with Fat Embolism in a Porcine Donor Model

    M. Irie, S. Otani, T. Kurosaki, Y. Shikatani, K. Mesaki, K. Hashimoto, S. Tanaka, K. Miyahara, T. Ohki, K. Miyoshi, S. Sugimoto, M. Yamane, S. Miyoshi, T. Oto

    The Journal of Heart and Lung Transplantation   36 ( 4 )   S374 - S375   2017.4

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    DOI: 10.1016/j.healun.2017.01.1064

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  • Prognostic Factors in Lung Transplantation After Hematopoietic Stem Cell Transplantation

    Seiichiro Sugimoto

    The Journal of Heart and Lung Transplantation   2017.4

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  • Clinical Characteristics & Outcomes of Restrictive CLAD After Bilateral Living-Donor Lobar Lung Transplantation

    K. Mesaki, K. Miyoshi, S. Namura, T. Kurosaki, S. Otani, S. Sugimoto, M. Yamane, S. Miyoshi, T. Oto

    The Journal of Heart and Lung Transplantation   36 ( 4 )   2017.4

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    DOI: 10.1016/j.healun.2017.01.1506

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  • 肉腫多発肺転移に対する肺切除術

    難波 圭, 豊岡 伸一, 枝園 和彦, 山本 寛斉, 宗 淳一, 黒崎 毅史, 三好 健太郎, 大谷 真二, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 三好 新一郎

    日本呼吸器外科学会雑誌   31 ( 3 )   RO6 - 6   2017.4

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  • 乳児混合性白血病に対する造血幹細胞移植後の重症慢性肺GVHDに対して両側脳死肺移植を行った1例

    加登翔太, 半谷まゆみ, 三谷友一, 関正史, 大谷真二, 杉本誠一郎, 樋渡光輝, 樋渡光輝, 大藤剛宏, 滝田順子

    日本造血細胞移植学会総会プログラム・抄録集   39th   296   2017.2

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  • Impact of Prognostic Nutrition Index for Induction Chemoradiotherapy Followed by Surgery in Locally Advanced Non-Small Lung Cancers

    Junichi Soh, Shinichi Toyooka, Kazuhiko Shien, Hiromasa Yamamoto, Tsuyoshi Kurosaki, Kentaro Miyoshi, Shinji Otani, Seiichiro Sugimoto, Masaomi Yamane, Takahiro Oto, Susumu Kanazawa, Katsuyuki Kiura, Shinichiro Miyoshi

    JOURNAL OF THORACIC ONCOLOGY   12 ( 1 )   S880 - S881   2017.1

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    DOI: 10.1016/j.jtho.2016.11.1201

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  • Clinical Outcomes of Induction Chemoradiotherapy with High Dose Chest Radiation for Locally Advanced Non-Small Cell Lung Cancer Patients

    Hidejiro Torigoe, Shinichi Toyooka, Kazuhiko Shien, Junichi Soh, Hiromasa Yamamoto, Kentaro Miyoshi, Seiichiro Sugimoto, Masaomi Yamane, Takahiro Oto, Kuniaki Katsui, Katsuyuki Hotta, Susumu Kanazawa, Katsuyuki Kiura, Shinichiro Miyoshi

    JOURNAL OF THORACIC ONCOLOGY   12 ( 1 )   S851 - S851   2017.1

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    DOI: 10.1016/j.jtho.2016.11.1156

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  • The Advantage of Induction Chemoradiotherapy in Bronchoplastic Procedure for Non-Small Cell Lung Cancer Accompanied with Central Disease Region

    Hiroki Sato, Shinichi Toyooka, Takeshi Kurosaki, Kazuhiko Shien, Kentaro Miyoshi, Shinji Ohtani, Hiromasa Yamamoto, Seiichiro Sugimoto, Junichi Soh, Masaomi Yamane, Takahiro Oto, Shinichiro Miyoshi

    JOURNAL OF THORACIC ONCOLOGY   12 ( 1 )   S868 - S869   2017.1

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  • 両側生体肺移植後に生じた拘束型CLADの7例

    目崎久美, 三好健太郎, 名村咲音, 黒崎毅史, 大谷真二, 杉本誠一郎, 山根正修, 三好新一郎, 大藤剛宏

    日本呼吸器外科学会総会(Web)   34th   ROMBUNNO.O16‐4 (WEB ONLY)   2017

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  • 術前化学放射線療法が奏効し完全切除し得た左房浸潤を伴う局所進行肺癌の1例

    高橋優太, 枝園和彦, 宗淳一, 豊岡伸一, 黒崎毅史, 三好健太郎, 大谷真二, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   34th ( 3 )   ROMBUNNO.P10‐2 (WEB ONLY) - 2   2017

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  • カルタゲナー症候群に対する脳死肺移植の経験

    山本治慎, 杉本誠一郎, 大谷真二, 黒崎毅史, 三好健太郎, 山根正修, 三好新一郎, 大藤剛宏

    日本肺および心肺移植研究会プログラム・抄録集   33rd   33   2017

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  • 気道再建術の要点―局所進行肺癌に対する術前化学放射線療法後手術を中心に―

    豊岡伸一, 佐藤博紀, 枝園和彦, 宗淳一, 山本寛斉, 黒崎毅史, 三好健太郎, 大谷真二, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   34th ( 3 )   ROMBUNNO.PD2‐5 (WEB ONLY) - 5   2017

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  • 肺移植後患者に対する皮下注型グロブリン製剤の使用経験

    二萬英斗, 三好健太郎, 黒崎毅史, 大谷真二, 杉本誠一郎, 山根正修, 三好新一郎, 大藤剛宏

    日本肺および心肺移植研究会プログラム・抄録集   33rd   25   2017

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  • 左肺下葉切除後に冠状動脈損傷をきたした一例

    栗原英祐, 山本寛斉, 豊岡伸一, 小谷恭弘, 大越祐介, 枝園和彦, 黒崎毅史, 三好健太郎, 大谷真二, 杉本誠一郎, 宗淳一, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   34th ( 3 )   ROMBUNNO.P102‐1 (WEB ONLY) - 1   2017

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  • 線維性縦隔炎の一例

    大越祐介, 山本寛斉, 牧佑歩, 枝園和彦, 黒崎毅史, 三好健太郎, 大谷真二, 杉本誠一郎, 宗淳一, 山根正修, 豊岡伸一, 大藤剛宏, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   34th ( 3 )   ROMBUNNO.P47‐6 (WEB ONLY) - 6   2017

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  • 肺移植患者における胸骨横切開術後胸骨合併症の検討

    山本治慎, 杉本誠一郎, 大谷真二, 黒崎毅史, 枝園和彦, 三好健太郎, 山本寛斉, 宗淳一, 山根正修, 豊岡伸一, 三好新一郎, 大藤剛宏

    日本呼吸器外科学会総会(Web)   34th ( 3 )   ROMBUNNO.P99‐6 (WEB ONLY) - 6   2017

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  • 外科における分子標的治療の役割

    山本寛斉, 枝園和彦, 宗淳一, 諏澤憲, 渡邉元嗣, 佐藤博紀, 鳥越英次郎, 難波圭, 黒崎毅史, 三好健太郎, 大谷真二, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎, 豊岡伸一

    日本呼吸器外科学会総会(Web)   34th ( 3 )   ROMBUNNO.RO9‐4 (WEB ONLY) - 4   2017

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  • CTスコア法による両側生体肺移植後CLADの評価

    名村咲音, 三好健太郎, 黒崎毅史, 大谷真二, 杉本誠一郎, 山根正修, 三好新一郎, 大藤剛宏

    日本肺および心肺移植研究会プログラム・抄録集   33rd   26   2017

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  • Lung Allocation Score Does Not Reflect Post-Lung Transplant Outcome in a Use of Low Risk Donor

    黒崎毅史, 大谷真二, 山本治慎, 田中真, 橋本好平, 目崎久美, 宮原一彰, 鹿谷芳伸, 二萬英斗, 大亀剛, 入江真大, 三好健太郎, 杉本誠一郎, 山根正修, 三好新一郎, 大藤剛宏

    日本呼吸器外科学会総会(Web)   34th   ROMBUNNO.O16‐2 (WEB ONLY)   2017

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  • ドナー挿管期間に着目したスコアリング法による肺移植ドナー評価の有用性

    田中真, 三好健太郎, 黒崎毅, 大谷真二, 杉本誠一郎, 山根正修, 大藤剛宏

    日本呼吸器外科学会総会(Web)   34th   ROMBUNNO.O16‐3 (WEB ONLY)   2017

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  • 脳死肺移植における不十分なドナー左房カフに対する再建術

    杉本誠一郎, 大谷真二, 黒崎毅史, 三好健太郎, 山根正修, 三好新一郎, 大藤剛宏

    日本呼吸器外科学会総会(Web)   34th   ROMBUNNO.P99‐7 (WEB ONLY)   2017

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  • 局所進行非小細胞肺癌の術前化学放射線療法後手術後の術後再発に対する局所治療は有効か?

    宗淳一, 諏澤憲, 豊岡伸一, 枝園和彦, 山本寛斉, 黒崎毅史, 三好健太郎, 大谷真二, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   34th ( 3 )   ROMBUNNO.RO11‐6 (WEB ONLY) - 6   2017

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  • 脳死片肺移植術施行中,グラフト再灌流の際に突然のST上昇・Bispectral index(BIS)値の低下を来たした一例

    前田明倫, 日笠友起子, 岡原修司, 大亀剛, 杉本誠一郎, 大藤剛宏, 小林求

    日本肺および心肺移植研究会プログラム・抄録集   33rd   24   2017

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  • Clinical Characteristics Of Japanese Candidates For Lung Transplant Due To Interstitial Lung Disease And Risk Factors For Early Death While On The Waiting List

    H. Higo, E. Ichihara, T. Kurosaki, K. Miyoshi, T. Kubo, S. Otani, S. Sugimoto, M. Yamane, N. Miyahara, K. Kiura, T. Oto

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   195   2017

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  • Stage 3胸腺癌に対する導入放射線療法後の手術におけるsemi-clamshellアプローチ

    川名 伸一, 三好 健太郎, 橋本 好平, 黒崎 毅史, 牧 佑歩, 大谷 真二, 山本 寛斉, 杉本 誠一郎, 宗 淳一, 山根 正修, 豊岡 伸一, 大藤 剛宏, 三好 新一郎

    肺癌   56 ( 7 )   1087 - 1087   2016.12

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  • 右肺三葉合流部に発生し,安全に切除できた巨大孤発性線維性腫瘍の一例

    鹿谷芳伸, 宗淳一, 下田篤史, 黒崎毅史, 三好健太郎, 大谷真二, 山本寛斉, 杉本誠一郎, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本肺癌学会総会号   57th ( 6 )   611 - 611   2016.11

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  • 陽型肺腺癌の1切除例

    清水大, 三好健太郎, 目崎久美, 枝園和彦, 杉本誠一郎, 山本寛斉, 宗淳一, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本肺癌学会総会号   57th   682   2016.11

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  • 肺癌に対する左上葉切除後に発症した食道アカラシアの1例

    二萬英斗, 宗淳一, 枝園和彦, 豊岡伸一, 黒崎毅史, 大谷真二, 三好健太郎, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本肺癌学会総会号   57th ( 6 )   749 - 749   2016.11

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  • 導入療法後肺切除時の大網被覆により術後胃排出障害を生じた2例

    土生智大, 枝園和彦, 豊岡伸一, 宗淳一, 二萬英斗, 山本寛斉, 黒崎毅史, 三好健太郎, 大谷真二, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本肺癌学会総会号   57th ( 6 )   851 - 851   2016.11

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  • FDGの高集積を伴う巨大前縦隔腫瘍を呈したCastleman病の1切除例

    大谷真二, 杉本誠一郎, 田中顕之, 鹿谷芳伸, 黒崎毅史, 枝園和彦, 三好健太郎, 山本寛斉, 宗淳一, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本肺癌学会総会号   57th ( 6 )   595 - 595   2016.11

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  • 肉腫肺転移に対して区域切除以上の肺切除を施行した患者における術前予後予測因子の検討

    山本治慎, 豊岡伸一, 山本寛斉, 宗淳一, 枝園和彦, 黒崎毅史, 三好健太郎, 大谷真二, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本肺癌学会総会号   57th ( 6 )   534 - 534   2016.11

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  • 非小細胞肺癌切除症例における術前血漿中抗RPL29抗体価と予後

    山本寛斉, 山本寛斉, 高木章乃夫, 林達朗, 古川公之, 田尾裕之, 枝園和彦, 宗淳一, 大谷真二, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 岡部和倫, 三好新一郎, 豊岡伸一

    日本肺癌学会総会号   57th ( 6 )   518 - 518   2016.11

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  • 右残肺全摘後の気管支断端瘻に対し,ヒストアクリルによる閉鎖術が有効であった1例

    勝部璃子, 宗淳一, 豊岡伸一, 黒崎毅史, 枝園和彦, 三好健太郎, 大谷真二, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本肺癌学会総会号   57th ( 6 )   643 - 643   2016.11

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  • 高線量照射による術前化学放射線療法後手術症例の検討

    鳥越英次郎, 豊岡伸一, 枝園和彦, 三好健太郎, 山本寛斉, 杉本誠一郎, 宗淳一, 山根正修, 大藤剛宏, 三好新一郎

    日本肺癌学会総会号   57th ( 6 )   525 - 525   2016.11

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  • 局所進行非小細胞肺癌の術前化学放射線療法後手術における予後栄養指数(PNI)の治療効果への影響

    宗淳一, 豊岡伸一, 枝園和彦, 山本寛斉, 黒崎毅史, 三好健太郎, 大谷真二, 杉本誠一郎, 山根正修, 大藤剛宏, 木浦勝行, 金澤右

    日本肺癌学会総会号   57th ( 6 )   782 - 782   2016.11

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  • 腸型肺腺癌の1切除例

    清水 大, 三好 健太郎, 目崎 久美, 枝園 和彦, 杉本 誠一郎, 山本 寛斉, 宗 淳一, 豊岡 伸一, 大藤 剛宏, 三好 新一郎

    肺癌   56 ( 6 )   682 - 682   2016.11

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  • 岡山大学における移植肺の長期生着に関する問題点

    大谷真二, 杉本誠一郎, 黒崎毅史, 三好健太郎, 大河知世, 山根正修, 三好新一郎, 大藤剛宏

    日本移植学会総会プログラム抄録集   52nd   221   2016.9

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  • 本邦における造血幹細胞移植後の肺移植の検討

    陳豊史, 杉本誠一郎, 白石武史, 南正人, 松田安史, 千田雅之, 前田寿美子, 青山晃博, 岡田克典, 奥村明之進, 岩崎昭憲, 三好新一郎, 大藤剛宏, 伊達洋至

    日本移植学会総会プログラム抄録集   52nd   317   2016.9

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  • 臓器摘出手術時の循環動態不安定時の対策

    山根正修, 杉本誠一郎, 三好健太郎, 大谷真二, 黒崎毅, 大藤剛宏, 三好新一郎

    日本移植学会総会プログラム抄録集   52nd   409   2016.9

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  • 両側生体肺移植後、BOSの加療中に拘束型CLADに移行した1例

    目崎 久美, 三好 健太郎, 橋本 好平, 黒崎 毅史, 大谷 真二, 杉本 誠一郎, 山根 正修, 三好 新一郎, 大藤 剛宏

    移植   51 ( 2-3 )   233 - 233   2016.8

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  • 肺移植後Tacrolimus徐放性製剤(グラセプター)の使用経験

    二萬 英斗, 三好 健太郎, 大藤 剛宏, 鹿谷 芳伸, 田中 真, 橋本 好平, 目崎 久美, 宮原 一彰, 大亀 剛, 入江 真大, 平野 豊, 黒崎 毅史, 大谷 真二, 杉本 誠一郎, 山根 正修, 三好 新一郎

    移植   51 ( 2-3 )   262 - 262   2016.8

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  • 肺移植での術中出血量を減少させる工夫 側副血行路クリッピングの効果

    今西 謙太郎, 杉本 誠一郎, 入江 真大, 黒崎 毅史, 三好 健太郎, 大谷 真二, 山根 正修, 三好 新一郎, 大藤 剛宏

    移植   51 ( 2-3 )   250 - 250   2016.8

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  • 肺移植後患者及びその家族への集団指導とピアサポートの役割

    横山 千恵, 本郷 恵理, 大月 絢加, 福島 嘉子, 森岡 未来, 金治 麻菜美, 大河 知世, 瀬浪 典子, 佐原 優子, 宮原 一彰, 三好 健太郎, 大谷 真二, 杉本 誠一郎, 山根 正修, 大藤 剛宏

    移植   51 ( 2-3 )   252 - 252   2016.8

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  • ハイブリッド肺移植の経験

    大藤 剛宏, 小林 求, 三好 健太郎, 杉本 誠一郎, 大谷 真二, 黒崎 毅史, 大亀 剛, 平野 豊, 入江 真大, 宮原 一彰, 横山 千恵, 日笠 友起子, 川西 秀明, 大河 知世, 山根 正修, 三好 新一郎

    移植   51 ( 2-3 )   247 - 247   2016.8

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  • 出血性肺梗塞ドナーを利用した両側脳死肺移植の一例

    鹿谷 芳伸, 三好 健太郎, 橋本 好平, 目崎 久美, 二萬 英斗, 入江 真人, 平野 豊, 黒崎 毅史, 大谷 真二, 杉本 誠一郎, 山根 正修, 三好 新一郎, 大藤 剛宏

    移植   51 ( 2-3 )   248 - 248   2016.8

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  • 肺移植患者における腎機能に応じたバルガンシクロビル予防投与の検討

    川西 秀明, 村川 公央, 北村 佳久, 黒崎 毅史, 三好 健太郎, 大谷 真二, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 千堂 年昭

    移植   51 ( 2-3 )   263 - 263   2016.8

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  • 診療参加型臨床実習におけるmini‐CEXの導入:多数の具体的達成・評価項目表の再構築

    杉本誠一郎, 大谷真二, 山根正修

    医学教育   47 ( Suppl. )   122   2016.7

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  • 胸骨原発軟骨肉腫に対し、胸骨体・左右肋軟骨部分切除およびpolypropylene meshによる胸壁再建を施行した1例

    川名 伸一, 山本 寛斉, 牧 佑歩, 黒崎 毅史, 三好 健太郎, 大谷 真二, 杉本 誠一郎, 宗 淳一, 山根 正修, 豊岡 伸一, 大藤 剛宏, 三好 新一郎

    日本臨床外科学会雑誌   77 ( 7 )   1863 - 1863   2016.7

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  • 多発性肺動静脈瘻に対するコイル塞栓部に生じた非結核性抗酸菌症の1例

    目崎 久美, 杉本 誠一郎, 大亀 剛, 黒崎 毅史, 牧 佑歩, 三好 健太郎, 大谷 真二, 山本 寛斉, 宗 淳一, 山根 正修, 豊岡 伸一, 大藤 剛宏, 三好 新一郎

    日本臨床外科学会雑誌   77 ( 7 )   1863 - 1863   2016.7

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  • 臨床実習終了時OSCEにおける手術室内を想定したシナリオによる清潔操作・患者安全評価の試み

    大谷 真二, 杉本 誠一郎, 万代 康弘, 豊岡 伸一, 大藤 剛宏, 三好 新一郎, 山根 正修

    医学教育   47 ( Suppl. )   212 - 212   2016.7

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  • IPAHに対する肺移植成績と長期内科治療がおよぼす影響

    三好健太郎, 三好健太郎, 黒崎毅史, 大谷真二, 杉本誠一郎, 山根正修, 大藤剛宏

    呼吸と循環   64 ( 5 )   S57   2016.5

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  • 慢性進行性肺アスペルギルス症治療改善後に同一空洞内発育を呈し診断に苦慮した肺扁平上皮癌の2例

    濱田昇, 板野純子, 谷本安, 杉本誠一郎, 大藤剛宏

    気管支学   38   S367   2016.5

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  • 肺移植後の気管支合併症に対する気管支鏡下治療

    杉本誠一郎, 大谷真二, 三好健太郎, 三好新一郎, 大藤剛宏

    気管支学   38   S167   2016.5

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  • 胸骨原発軟骨肉腫に対し,胸骨体・左右肋軟骨部分切除およびpolypropylene meshによる胸壁再建を施行した1例

    川名伸一, 山本寛斉, 牧佑歩, 黒崎毅史, 三好健太郎, 大谷真二, 杉本誠一郎, 宗淳一, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    岡山医学会雑誌   128 ( 1 )   80‐81 - 81   2016.4

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  • 多発性肺動静脈瘻に対するコイル塞栓部に生じた非結核性抗酸菌症の1例

    目崎久美, 杉本誠一郎, 大亀剛, 黒崎毅史, 牧佑歩, 三好健太郎, 大谷真二, 山本寛斉, 宗淳一, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    岡山医学会雑誌   128 ( 1 )   81 - 81   2016.4

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  • Cadaveric Lobar Lung Transplantation Based on the Experiences of Living-Donor Lobar Lung Transplantation

    M. Irie, S. Sugimoto, T. Kurosaki, K. Miyoshi, S. Otani, M. Yamane, T. Oto, S. Miyoshi

    The Journal of Heart and Lung Transplantation   35 ( 4 )   2016.4

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    DOI: 10.1016/j.healun.2016.01.1052

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  • Prolonged Warm Ischemia Prevents Lung Allograft Acceptance in Lung Transplantation from Donation after Cardiac Death in the Mouse

    Y. Hirano, S. Sugimoto, T. Kurosaki, S. Otani, K. Miyoshi, M. Yamane, T. Oto, S. Miyoshi

    The Journal of Heart and Lung Transplantation   35 ( 4 )   S143 - S144   2016.4

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    DOI: 10.1016/j.healun.2016.01.396

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  • Refinement of Lung Donor Scoring System with Consideration for Negative Impact of Prolonged Donor Intubation Time

    S. Tanaka, K. Miyoshi, T. Kurosaki, S. Otani, S. Sugimoto, M. Yamane, T. Oto

    The Journal of Heart and Lung Transplantation   35 ( 4 )   2016.4

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    DOI: 10.1016/j.healun.2016.01.1064

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  • Not Donor’s but Recipient’s Airway Organisms Are Relevant to Post-Lung Transplant Pneumonia

    K. Miyoshi, Y. Konishi, T. Kurosaki, S. Otani, S. Sugimoto, M. Yamane, S. Miyoshi, T. Oto

    The Journal of Heart and Lung Transplantation   35 ( 4 )   2016.4

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    DOI: 10.1016/j.healun.2016.01.880

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  • Prolonged Administration of Twice Daily Bolus Intravenous Tacrolimus Early after Lung Transplantation

    Y. Hirano, S. Sugimoto, T. Mano, T. Kurosaki, S. Otani, K. Miyoshi, M. Yamane, S. Miyoshi, T. Oto

    The Journal of Heart and Lung Transplantation   35 ( 4 )   2016.4

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    DOI: 10.1016/j.healun.2016.01.676

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  • Lung Allocation Score Does Not Reflect Post-Lung Transplant Outcome in a Use of Low Risk Donor

    T. Kurosaki, K. Miyoshi, K. Imanishi, T. Okawa, S. Otani, S. Sugimoto, M. Yamane, S. Miyoshi, T. Oto

    The Journal of Heart and Lung Transplantation   35 ( 4 )   2016.4

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    DOI: 10.1016/j.healun.2016.01.037

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  • [Cross-sectoral Approach of a Perioperative Management Center for General Thoracic Surgery].

    Atsushi Shimoda, Junichi Soh, Takako Ashiba, Naomichi Murata, Tomomi Fukuda, Motomu Kobayashi, Hidejiro Torigoe, Yuho Maki, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka, Takahiro Oto, Shinichiro Miyoshi

    Kyobu geka. The Japanese journal of thoracic surgery   69 ( 1 )   20 - 4   2016.1

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    Perioperative assessment and care, such as enhanced recovery after surgery (ERAS), is very important for improving the clinical outcomes of patients who have undergone surgery. However, professional assessments and care cannot be achieved through the actions of only 1 surgical department. We established a perioperative management center(PERIO) comprised of surgeons, dedicated nurses, anesthesiologists, dentists, physiotherapists, pharmacists, and nutritionists to perform intensive cross-sectoral perioperative management. In this manuscript, we investigated the impact of PERIO on the clinical outcomes of 127 elderly patients who underwent thoracic surgery for the resection of non-small cell lung cancer (NSCLC). We categorized these 127 patients into 3 groups:① those treated before the introduction of PERIO (between January 2006 to August 2008), ② those treated during the early phase after PERIO introduction (September 2008 to December 2011), and ③ those treated during the late phase after PERIO introduction( January 2012 to December 2014). Radical operations were performed significantly more frequently after PERIO introduction than before PERIO introduction, while the postoperative complication rates were similar among the 3 groups. The duration of postoperative hospitalization was reduced after the introduction of PERIO, and the hospital surplus increased after the introduction of PERIO. In conclusion, PERIO may play an important role in improving the clinical outcomes of thoracic surgery, especially for elderly patients with NSCLC.

    DOI: 10.15106/J00349.2016107863

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  • CO2送気併用による,鏡視下胸腺摘出術の利点と欠点

    牧佑歩, 宗淳一, 黒崎毅史, 大谷真二, 三好健太郎, 山本寛斉, 杉本誠一郎, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   33rd ( 3 )   P42‐2 (WEB ONLY) - 2   2016

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  • サイモグロブリンを使用した肺移植後急性拒絶反応の6例

    黒崎毅史, 大谷真二, 田中真, 宮原一彰, 大亀剛, 入江真大, 平野豊, 三好健太郎, 杉本誠一郎, 山根正修, 三好新一郎, 大藤剛宏

    日本呼吸器外科学会総会(Web)   33rd   O21‐5 (WEB ONLY)   2016

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  • 肺癌の分子生物学の進歩と外科診療への応用

    山本寛斉, 豊岡伸一, 諏澤憲, 宗淳一, 牧佑歩, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   33rd ( 3 )   SY2‐1 (WEB ONLY) - 1   2016

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  • 肺移植後気管支合併症の特徴と長期予後:生体肺移植と脳死肺移植の違い

    杉本誠一郎, 黒崎毅史, 三好健太郎, 大谷真二, 牧佑歩, 山本寛斉, 宗淳一, 山根正修, 豊岡伸一, 三好新一郎, 大藤剛宏

    日本呼吸器外科学会総会(Web)   33rd ( 3 )   PD1‐2 (WEB ONLY) - 2   2016

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  • 肺移植患者における腎機能に応じたバルガンシクロビル予防投与の検討

    川西秀明, 村川公央, 北村佳久, 黒崎毅史, 三好健太郎, 大谷真二, 杉本誠一郎, 山根正修, 大藤剛宏, 千堂年昭

    日本肺および心肺移植研究会プログラム・抄録集   32nd   40   2016

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  • 診療科横断的周術期管理による,呼吸器外科手術後の合併症対策

    牧佑歩, 宗淳一, 鳥越英次郎, 黒崎毅史, 三好健太郎, 大谷真二, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 森田瑞樹, 豊岡伸一, 三好新一郎

    日本外科学会定期学術集会(Web)   116th   PS‐094‐7 (WEB ONLY) - 7   2016

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  • 肺移植での術中出血量を減少させる工夫―側副血行路クリッピングの効果

    今西謙太郎, 杉本誠一郎, 入江真大, 黒崎毅史, 三好健太郎, 大谷真二, 山根正修, 三好新一郎, 大藤剛宏

    日本肺および心肺移植研究会プログラム・抄録集   32nd   27   2016

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  • ハイブリッド肺移植の経験

    大藤剛宏, 小林求, 三好健太郎, 杉本誠一郎, 大谷真二, 黒崎毅史, 大亀剛, 平野豊, 入江真大, 宮原一彰, 横山千恵, 日笠友起子, 川西秀明, 大河知世, 山根正修, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   32nd   24   2016

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  • 出血性肺梗塞ドナーを利用した両側脳死肺移植の一例

    鹿谷芳伸, 三好健太郎, 橋本好平, 目崎久美, 二萬英斗, 入江真人, 平野豊, 黒崎毅史, 大谷真二, 杉本誠一郎, 山根正修, 三好新一郎, 大藤剛宏

    日本肺および心肺移植研究会プログラム・抄録集   32nd   25   2016

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  • 両側生体肺移植後,BOSの加療中に拘束型CLADに移行した1例

    目崎久美, 三好健太郎, 橋本好平, 黒崎毅史, 大谷真二, 杉本誠一郎, 山根正修, 三好新一郎, 大藤剛宏

    日本肺および心肺移植研究会プログラム・抄録集   32nd   10   2016

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  • 肺移植後患者及びその家族への集団指導とピアサポートの役割

    横山千恵, 本郷恵理, 大月絢加, 福島嘉子, 森岡未来, 金治麻菜美, 大河知世, 瀬浪典子, 佐原優子, 宮原一彰, 三好健太郎, 大谷真二, 杉本誠一郎, 山根正修, 大藤剛宏

    日本肺および心肺移植研究会プログラム・抄録集   32nd   29   2016

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  • 非小細胞肺癌に対する根治的放射線化学療法後手術の治療成績

    宗淳一, 豊岡伸一, 山本寛斉, 牧佑歩, 黒崎毅史, 三好健太郎, 大谷真二, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   33rd ( 3 )   O2‐6 (WEB ONLY) - 6   2016

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  • Stage3胸腺癌に対する導入放射線療法後の手術におけるsemi‐clamshellアプローチ

    川名伸一, 三好健太郎, 橋本好平, 黒崎毅史, 牧佑歩, 大谷真二, 山本寛斉, 杉本誠一郎, 宗淳一, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    肺癌(Web)   56 ( 7 )   1087(J‐STAGE)   2016

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  • 全診療科中で学生評価の最も高い呼吸器外科臨床実習の実践

    山根正修, 杉本誠一郎, 三好健太郎, 山本寛斉, 宗淳一, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   33rd ( 3 )   O11‐2 (WEB ONLY) - 2   2016

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  • Pathologically proven cN2局所進行非小細胞肺癌に対する術前化学放射線治療後手術療法の治療成績

    目崎久美, 宗淳一, 豊岡伸一, 鳥越英次郎, 佐藤博紀, 黒崎毅史, 牧佑歩, 三好健太郎, 大谷真二, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   33rd ( 3 )   P8‐8 (WEB ONLY) - 8   2016

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  • 初回肺移植後症例における再移植の忍容性

    三好健太郎, 黒崎毅史, 大谷真二, 杉本誠一郎, 山根正修, 三好新一郎, 大藤剛宏

    日本呼吸器外科学会総会(Web)   33rd   PD1‐5 (WEB ONLY)   2016

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  • cN2stage IIIA非小細胞肺癌に対する導入化学放射線治療後外科療法の成績

    目崎久美, 豊岡伸一, 宗淳一, 鳥越英次郎, 諏澤憲, 牧祐歩, 山本寛斉, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 伊達洋至, 三好新一郎

    日本外科学会定期学術集会(Web)   116th   OP‐030‐2 (WEB ONLY) - 2   2016

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  • 肺移植後Tacrolimus徐放性製剤(グラセプター)の使用経験

    二萬英斗, 三好健太郎, 大藤剛宏, 鹿谷芳伸, 田中真, 橋本好平, 目崎久美, 宮原一彰, 大亀剛, 入江真大, 平野豊, 黒崎毅史, 大谷真二, 杉本誠一郎, 山根正修, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   32nd   39   2016

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  • 肺動静脈瘻に対するコイル塞栓術に起因した非結核性抗酸菌症の1手術例

    目崎久美, 杉本誠一郎, 大亀剛, 山根正修, 黒崎毅史, 牧佑歩, 三好健太郎, 大谷真二, 山本寛斉, 宗淳一, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   33rd ( 3 )   P68‐3 (WEB ONLY) - 3   2016

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  • 肉腫肺転移に対する肺切除の検討

    山本寛斉, 豊岡伸一, 宗淳一, 牧佑歩, 黒崎毅史, 三好健太郎, 大谷真二, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   33rd ( 3 )   O5‐4 (WEB ONLY) - 4   2016

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  • 局所進行非小細胞肺癌に対する術前導入化学放射線療法後のスリーブ肺葉切除術の検討

    豊岡伸一, 宗淳一, 山本寛斉, 牧佑歩, 大谷真二, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   33rd ( 3 )   IS2‐4 (WEB ONLY) - 4   2016

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  • Remodelling-Related Molecular Profiles In Different Subforms Of Chronic Lung Allograft Dysfunction

    D. Jonigk, B. Rath, L. Maegel, H. Golpon, N. Izykowski, T. Welte, S. Janciauskene, J. Gottlieb, G. Warnecke, A. Haverich, H. Kreipe, M. P. Kuehnel, F. Laenger

    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE   193   21   2016

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  • 肺移植後の腹骨盤域に残存するリンパ脈管筋腫症に対するシロリムスの治療効果:症例報告

    内嶺陽平, 須野学, 須野学, 伊藤雄大, 山本健人, 中西里佳, 伊藤明花, 三好健太郎, 山根正修, 杉本誠一郎, 大藤剛宏

    日本医療薬学会年会講演要旨集(Web)   26   2016

  • 移植医療を支える臨床検査 肺移植と臨床検査

    杉本誠一郎, 大藤剛宏, 三好新一郎, 三好新一郎

    臨床検査   59 ( 13 )   1498 - 1502   2015.12

  • 前縦隔滑膜肉腫の1切除例

    下田 篤史, 宋 淳一, 黒崎 毅史, 三好 健太郎, 牧 佑歩, 大谷 真二, 山本 寛斎, 杉本 誠一郎, 山根 正修, 豊岡 伸一, 大藤 剛宏, 三好 新一郎

    肺癌   55 ( 7 )   1115 - 1116   2015.12

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  • 人工気胸下の胸腔鏡手術で切除可能であった胸腔内巨大孤立性線維性腫瘍の1例

    宮原 一彰, 宗 淳一, 牧 佑歩, 黒崎 毅史, 三好 健太郎, 大谷 真二, 山本 寛斉, 杉本 誠一郎, 山根 正修, 豊岡 伸一, 大藤 剛宏, 三好 新一郎

    肺癌   55 ( 7 )   1118 - 1118   2015.12

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  • 肺移植患者におけるミコフェノール酸による移植後早期の下痢発現リスク因子の検討

    伊藤雄大, 須野学, 須野学, 坂本健太, 吉崎祐太, 川西秀明, 千堂年昭, 三好健太郎, 山根正修, 杉本誠一郎, 大藤剛宏

    日本医療薬学会年会講演要旨集   25th   328 - 328   2015.10

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  • 仰臥位,腹臥位の肺癌手術における,胸腔内送気併用下での審査胸腔鏡の有用性

    牧佑歩, 宗淳一, 三好健太郎, 大谷真二, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 豊岡伸一, 三好新一郎

    日本肺癌学会総会号   56th ( 5 )   447 - 447   2015.10

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  • 局所進行肺癌に対する術中3DCTナビゲーションを使用した椎体合併切除術

    杉本誠一郎, 牧佑歩, 三好健太郎, 大谷真二, 山本寛斉, 宗淳一, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本肺癌学会総会号   56th ( 5 )   407 - 407   2015.10

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  • 肺癌の局所浸潤の評価における術前呼吸同期4D‐CTの有用性

    難波圭, 渡邊元嗣, 宗淳一, 黒崎毅史, 牧佑歩, 三好健太郎, 大谷真二, 山本寛斉, 杉本誠一郎, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本肺癌学会総会号   56th ( 5 )   723 - 723   2015.10

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  • 4D‐CTと術中人工気胸が腫瘍局在評価に有用であった横隔膜原発solitary fibrous tumorの1例

    目崎久美, 宗淳一, 宮原一彰, 牧佑歩, 目黒毅史, 三好健太郎, 大谷真二, 山本寛斉, 杉本誠一郎, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本肺癌学会総会号   56th ( 5 )   548 - 548   2015.10

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  • 脳転移・多発縦隔リンパ節転移を伴った肺腺癌に対し,集学的治療により長期無再発生存を得た1例

    鹿谷芳伸, 山根正修, 牧佑歩, 黒崎毅史, 三好健太郎, 山本寛斉, 杉本誠一郎, 宗淳一, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本肺癌学会総会号   56th ( 5 )   728 - 728   2015.10

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  • 悪性胸膜中皮腫に対するREIC/Dkk‐3遺伝子治療

    山本寛斉, 枝園和彦, 牧佑歩, 宗淳一, 大谷真二, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 渡部昌実, 那須保友, 三好新一郎, 豊岡伸一

    日本肺癌学会総会号   56th ( 5 )   502 - 502   2015.10

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  • 両側生体肺移植後の片側性慢性拒絶反応に対し脳死片肺移植を施行した1例

    橋本好平, 杉本誠一郎, 大谷真二, 大河知世, 黒崎毅史, 三好健太郎, 山根正修, 三好新一郎, 大藤剛宏

    日本移植学会総会プログラム抄録集   51st   294   2015.9

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  • 小児肺移植における生体肺移植の進歩

    大谷真二, 杉本誠一郎, 黒崎毅史, 三好健太郎, 大河知世, 山根正修, 三好新一郎, 大藤剛宏

    日本移植学会総会プログラム抄録集   51st   255   2015.9

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  • 移植医療が日本でも一般的な医療になるために

    杉本誠一郎, 黒崎毅史, 大谷真二, 大河知世, 三好健太郎, 山根正修, 三好新一郎, 大藤剛宏

    日本移植学会総会プログラム抄録集   51st   190   2015.9

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  • 脳死下肺摘出の標準化に向けた当院での対策

    杉本誠一郎, 山根正修, 三好健太郎, 黒崎毅史, 大谷真二, 大河知世, 三好新一郎, 大藤剛宏

    日本移植学会総会プログラム抄録集   51st   231   2015.9

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  • Impact of Intensive Interprofessional Perioperative Management on Clinical Outcome in the Elderly Patients with Lung Cancer Surgery

    Hidejiro Torigoe, Junichi Soh, Takako Ashiwa, Takeshi Kurosaki, Shiny Ohtani, Yuho Maki, Kentaro Miyoshi, Hiromasa Yamamoto, Seiichiro Sugimoto, Masaomi Yamane, Shinichi Toyooka, Takahiro Oto, Shinichiro Miyoshi

    JOURNAL OF THORACIC ONCOLOGY   10 ( 9 )   S514 - S514   2015.9

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  • Feasibility of Median Sternotomy Approach for Locally Advanced Lung Cancer

    Hiroki Sato, Takeshi Kurosaki, Shinji Otani, Yuho Maki, Kentaro Miyoshi, Hiromasa Yamamoto, Seiichiro Sugimoto, Junichi Soh, Masaomi Yamane, Shinichi Toyooka, Takahiro Oto, Shinichiro Miyoshi

    JOURNAL OF THORACIC ONCOLOGY   10 ( 9 )   S415 - S415   2015.9

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  • 臓器の至適保存・機能評価・治療を目的とした体外臓器還流システムの可能性

    三好健太郎, 黒崎毅史, 大谷真二, 黒崎毅史, 大谷真二, 杉本誠一郎, 山根正修, 三好新一郎, 大藤剛宏, 大藤剛宏

    日本移植学会総会プログラム抄録集   51st   239   2015.9

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  • 遺伝性出血性毛細血管拡張症に伴う多発性肺動静脈瘻に対する両側脳死肺移植の1例

    大亀 剛, 杉本 誠一郎, 岡田 真典, 伊賀 徳周, 三好 健太郎, 山根 正修, 小林 求, 大藤 剛宏, 三好 新一郎

    移植   50 ( 2-3 )   325 - 325   2015.8

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  • 肺移植後の慢性期合併症に対する対策

    杉本 誠一郎, 大藤 剛宏, 三好 健太郎, 中谷 文, 大河 知世, 伊賀 徳周, 岡田 真典, 山根 正修, 三好 新一郎

    移植   50 ( 2-3 )   336 - 336   2015.8

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  • 肺移植後急性期細菌性肺炎におけるレシピエントおよびドナー因子の影響

    小西 祐輔, 入江 真大, 黒崎 毅史, 岡田 真典, 平野 豊, 伊賀 徳周, 三好 健太郎, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 三好 新一郎, 岡山大学病院呼吸器外科肺移植グループ

    移植   50 ( 2-3 )   336 - 336   2015.8

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  • 対側反転肺移植を行った2例

    伊賀 徳周, 大藤 剛宏, 宮原 一彰, 大亀 剛, 入江 真大, 黒崎 毅史, 平野 豊, 小西 祐輔, 岡田 真典, 三好 健太郎, 杉本 誠一郎, 山根 正修, 三好 新一郎

    移植   50 ( 2-3 )   332 - 333   2015.8

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  • 肺移植周術期におけるタクロリムスの経静脈投与法と経腸投与法の比較

    真野 俊史, 杉本 誠一郎, 小西 祐輔, 入江 真大, 平野 豊, 黒崎 毅史, 岡田 真典, 伊賀 徳周, 三好 健太郎, 山根 正修, 大藤 剛宏, 三好 新一郎

    移植   50 ( 2-3 )   333 - 334   2015.8

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  • Ex-vivo lung perfusionの臨床導入によるマージナル肺移植

    三好 健太郎, 大藤 剛宏, 大河 知世, 中谷 文, 平野 豊, 小西 祐輔, 伊賀 徳周, 岡田 真典, 杉本 誠一郎, 山根 正修, 三好 新一郎

    移植   50 ( 2-3 )   330 - 330   2015.8

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  • 2歳児に対する成人分割下葉を用いた両側生体肺区域移植

    大藤 剛宏, 山根 正修, 杉本 誠一郎, 三好 健太郎, 大亀 剛, 岡田 真典, 伊賀 徳周, 平野 豊, 中谷 文, 横山 千恵, 大河 知世, 入江 真大, 黒崎 毅史, 小西 祐輔, 平山 伸, 小林 求, 三好 新一郎

    移植   50 ( 2-3 )   331 - 331   2015.8

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  • Chronic Lung Allograft Dysfunction After Bilateral Living Donor Lobar Lung Transplantation

    K. Miyoshi, T. Oto, S. Sugimoto, M. Yamane, S. Miyoshi

    The Journal of Heart and Lung Transplantation   34 ( 4 )   2015.4

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    DOI: 10.1016/j.healun.2015.01.108

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  • Update on the Outcomes of Lung Transplantation After Hematopoietic Stem Cell Transplantation: A Single-Center Experience

    S. Sugimoto, T. Oto, M. Okada, N. Iga, K. Miyoshi, M. Yamane, S. Miyoshi

    The Journal of Heart and Lung Transplantation   34 ( 4 )   2015.4

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    DOI: 10.1016/j.healun.2015.01.710

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  • 局所進行性肺癌に対する胸骨正中切開アプローチの利用可能性(Feasibility of median sternotomy approach for locally advanced lung cancer)

    佐藤 博紀, 豊岡 伸一, 岡田 真典, 伊賀 徳周, 牧 佑歩, 三好 健太郎, 山本 寛斉, 杉本 誠一郎, 宗 淳一, 山根 正修, 大藤 剛宏, 三好 新一郎

    日本呼吸器外科学会雑誌   29 ( 3 )   O39 - 1   2015.4

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  • 肺移植後急性期細菌性肺炎におけるレシピエントおよびドナー因子の影響

    小西祐輔, 入江真大, 黒崎毅史, 岡田真典, 平野豊, 伊賀徳周, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   31st   44   2015

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  • 肺移植後に腸管気腫症を発症した3例

    大亀剛, 杉本誠一郎, 岡田真典, 伊賀徳周, 三好健太郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   32nd   O29-4 (WEB ONLY)   2015

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  • 肉腫多発肺転移に対する外科的治療の検討

    山本寛斉, 山本寛斉, 豊岡伸一, 豊岡伸一, 豊岡伸一, 高橋克仁, 高橋克仁, 宗淳一, 宗淳一, 牧佑歩, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本癌治療学会学術集会(Web)   53rd ( 3 )   P148‐2 (WEB ONLY) - 2590   2015

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  • 高齢者肺癌手術における組織横断的周術期管理の導入効果

    鳥越英次郎, 宗淳一, 豊岡伸一, 牧佑歩, 伊賀徳周, 岡田真典, 三好健太郎, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   32nd ( 3 )   GP-6 (WEB ONLY) - 6   2015

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  • 左下葉原発局所進行肺癌に対し術前導入化学放射線療法を施行後,左下葉・舌区スリーブ切除術を施行した4例

    山本寛斉, 豊岡伸一, 宗淳一, 牧佑歩, 岡田真典, 伊賀徳周, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   32nd ( 3 )   RV2-1 (WEB ONLY) - 1   2015

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  • 局所進行非小細胞肺癌に対する導入化学放射線治療後外科療法の成績

    豊岡伸一, 宗淳一, 諏澤憲, 牧祐歩, 山本寛斉, 伊賀周徳, 岡田真典, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   32nd ( 3 )   SY3-1 (WEB ONLY) - 1   2015

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  • 局所進行肺癌に対する導入化学放射線療法後の椎体合併切除術

    杉本誠一郎, 岡田真典, 大亀剛, 伊賀徳周, 牧佑歩, 三好健太郎, 山本寛斉, 宗淳一, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   32nd ( 3 )   V6-2 (WEB ONLY) - 2   2015

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  • 肺癌に対する最適化治療―家族性肺癌家系におけるHER2新規遺伝子変異発見の経験から

    山本寛斉, 豊岡伸一, 宗淳一, 牧佑歩, 岡田真典, 伊賀徳周, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   32nd ( 3 )   P39-10 (WEB ONLY) - 10   2015

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  • 原発性肺癌と肋骨ランゲルハンス細胞組織球症を合併した一例

    宮原一彰, 鳥越英次郎, 大亀剛, 牧佑歩, 岡田真典, 伊賀徳周, 三好健太郎, 山本寛斉, 杉本誠一郎, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   32nd   O44-5 (WEB ONLY)   2015

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  • IV期非小細胞肺癌の切除症例の検討

    牧佑歩, 豊岡伸一, 宗淳一, 岡田真典, 伊賀徳周, 三好健太郎, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   32nd ( 3 )   O42-6 (WEB ONLY) - 6   2015

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  • レシピエントの状態に応じ対側反転肺移植を行った2例

    伊賀徳周, 大藤剛宏, 宮原一彰, 大亀剛, 岡田真典, 三好健太郎, 杉本誠一郎, 山根正修, 三好新一郎

    日本呼吸器外科学会総会(Web)   32nd   V7-7 (WEB ONLY)   2015

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  • 局所進行非小細胞肺癌に対する根治的放射線化学療法後手術の治療成績

    宗淳一, 豊岡伸一, 諏澤憲, 岡田真典, 牧佑歩, 伊賀徳周, 三好健太郎, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 伊達洋至, 三好新一郎

    日本呼吸器外科学会総会(Web)   32nd ( 3 )   RO2-2 (WEB ONLY) - 2   2015

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  • 前縦隔滑膜肉腫の1切除例

    下田篤史, 宋淳一, 黒崎毅史, 三好健太郎, 牧佑歩, 大谷真二, 山本寛斎, 杉本誠一郎, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    肺癌(Web)   55 ( 7 )   1115‐1116(J‐STAGE)   2015

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  • cN2stage IIIA非小細胞肺癌に対する集学的治療の成績

    豊岡伸一, 宗淳一, 堀田勝幸, 勝井邦彰, 諏澤憲, 牧祐歩, 山本寛斉, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 伊達洋至, 金澤右, 木浦勝行, 三好新一郎

    日本癌治療学会学術集会(Web)   53rd ( 3 )   OS4‐4 (WEB ONLY) - 97   2015

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  • 人工気胸下の胸腔鏡手術で切除可能であった胸腔内巨大孤立性線維性腫瘍の1例

    宮原一彰, 宗淳一, 牧佑歩, 黒崎毅史, 三好健太郎, 大谷真二, 山本寛斉, 杉本誠一郎, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    肺癌(Web)   55 ( 7 )   1118(J‐STAGE)   2015

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  • 肺動脈性肺高血圧症に対する肺移植成績と長期内科治療がおよぼす影響

    三好健太郎, 杉本誠一郎, 山根正修, 三好新一郎, 大藤剛宏

    日本呼吸器外科学会総会(Web)   32nd   O29-2 (WEB ONLY)   2015

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  • 心嚢内腫瘍として発症したIgG4関連疾患の一例

    岡田真典, 杉本誠一郎, 伊賀徳周, 牧佑歩, 三好健太郎, 山本寛斉, 宗淳一, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   32nd ( 3 )   P54-8 (WEB ONLY) - 8   2015

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  • 完全胸腔鏡下右下葉切除中に肺動脈出血を来たした一例

    宗淳一, 豊岡伸一, 鳥越英次郎, 古川公之, 牧佑歩, 岡田真典, 伊賀徳周, 三好健太郎, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   32nd ( 3 )   V29-5 (WEB ONLY) - 5   2015

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  • 胸膜肺全摘術後に発症した無瘻性膿胸の2例

    鳥越英次郎, 豊岡伸一, 牧佑歩, 伊賀徳周, 岡田真典, 三好健太郎, 山本寛斉, 宗淳一, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   32nd ( 3 )   O31-2 (WEB ONLY) - 2   2015

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  • Ex‐vivo lung perfusionの臨床導入によるマージナル肺移植

    三好健太郎, 大藤剛宏, 大河知世, 中谷文, 平野豊, 小西祐輔, 伊賀徳周, 岡田真典, 杉本誠一郎, 山根正修, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   31st   29   2015

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  • 遺伝性出血性毛細血管拡張症に伴う多発性肺動静脈瘻に対する両側脳死肺移植の1例

    大亀剛, 杉本誠一郎, 岡田真典, 伊賀徳周, 三好健太郎, 山根正修, 小林求, 大藤剛宏, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   31st   16   2015

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  • 2歳児に対する成人分割下葉を用いた両側生体肺区域移植

    大藤剛宏, 山根正修, 杉本誠一郎, 三好健太郎, 大亀剛, 岡田真典, 伊賀徳周, 平野豊, 中谷文, 横山千恵, 大河知世, 入江真大, 黒崎毅史, 小西祐輔, 平山伸, 小林求, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   31st   32   2015

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  • 対側反転肺移植を行った2例

    伊賀徳周, 大藤剛宏, 宮原一彰, 大亀剛, 入江真大, 黒崎毅史, 平野豊, 小西祐輔, 岡田真典, 三好健太郎, 杉本誠一郎, 山根正修, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   31st   35   2015

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  • 肺移植後の慢性期合併症に対する対策

    杉本誠一郎, 大藤剛宏, 三好健太郎, 中谷文, 大河知世, 伊賀徳周, 岡田真典, 山根正修, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   31st   43   2015

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  • cN2 IIIA期非小細胞肺癌に対する術前化学放射線治療後手術の治療成績の検討

    宗淳一, 豊岡伸一, 諏澤憲, 岡田真典, 伊賀徳周, 牧佑歩, 三好健太郎, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 伊達洋至, 三好新一郎

    日本外科学会定期学術集会(Web)   115th   PD-24-5 (WEB ONLY) - 5   2015

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  • 肺移植周術期におけるタクロリムスの経静脈投与法と経腸投与法の比較

    真野俊史, 杉本誠一郎, 小西祐輔, 入江真大, 平野豊, 黒崎毅史, 岡田真典, 伊賀徳周, 三好健太郎, 山根正修, 大藤剛宏, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   31st   38   2015

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  • 術前放射線同時併用化学療法後手術を行った局所進行非小細胞肺癌の術後再発症例に対する局所治療の検討

    諏澤憲, 豊岡伸一, 堀田勝幸, 勝井邦彰, 宗淳一, 牧佑歩, 山本寛斉, 平木隆夫, 杉本誠一郎, 山根正修, 大藤剛宏, 金澤右, 木浦勝行, 三好新一郎

    日本肺癌学会総会号   55th ( 5 )   409 - 409   2014.10

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  • 80歳以上のI期肺癌手術症例における縮小手術の妥当性の検討

    鳥越英次郎, 宗淳一, 豊岡伸一, 牧佑歩, 伊賀徳周, 岡田真典, 三好健太郎, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本肺癌学会総会号   55th ( 5 )   383 - 383   2014.10

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  • 3期局所進行非小細胞肺癌に対する導入化学放射線治療後手術の治療成績

    宗淳一, 豊岡伸一, 枝園和彦, 岡田真典, 伊賀徳周, 牧佑歩, 三好健太郎, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 木浦勝行, 金澤右, 伊達洋至, 三好新一郎

    日本肺癌学会総会号   55th ( 5 )   417 - 417   2014.10

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  • 肺腺癌におけるHER2膜貫通領域の遺伝子変異と機能解析

    山本寛斉, 阪口政清, 諏澤憲, 大塚智昭, 枝園和彦, 橋田真輔, 渡邉元嗣, 牧佑歩, 宗淳一, 岡田真典, 伊賀徳周, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎, 豊岡伸一

    日本肺癌学会総会号   55th ( 5 )   362 - 362   2014.10

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  • 右側肺葉切除後,異時性肺癌に対し中葉温存肺葉切除を行った3例

    牧佑歩, 宗淳一, 豊岡伸一, 鳥越英次郎, 佐藤博紀, 大亀剛, 岡田真典, 伊賀徳周, 三好健太郎, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本肺癌学会総会号   55th ( 5 )   483 - 483   2014.10

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  • 導入化学放射線療法後に遠位大動脈弓部置換術を伴う広範囲切除を行ったcT4非小細胞肺癌の1例

    渡邉元嗣, 宗淳一, 入江真大, 岡田真典, 伊賀徳周, 牧佑歩, 三好健太郎, 山本寛斉, 杉本誠一郎, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本肺癌学会総会号   55th ( 5 )   357 - 357   2014.10

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  • [Open-chest management with Esmarch bandages after lung transplantation].

    Eito Niman, Takahiro Oto, Shinji Otani, Seiichiro Sugimoto, Masaomi Yamane, Junichi Soh, Shinichiro Miyoshi

    Kyobu geka. The Japanese journal of thoracic surgery   67 ( 10 )   884 - 7   2014.9

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    There are patients in whom management in an open-chest state after lung transplantation is necessary due to over-sized grafts, heart failure, use of extracorporeal membrane oxygenation (ECMO), or bleeding. In such patients, we suture Esmarch bandages, which are used for orthopedic surgery, to the open chest wound and perform wound management. We report 3 patients in whom wound management using this method was performed due to postoperative cardiac failure, primary graft dysfunction, and a postoperative pulmonary edema, respectively. Due to improvement in the wound management method and use of appropriate antibiotics, each patient could be managed without developing wound infection. This method was also useful for the management of bleeding.

    DOI: 10.15106/J00349.2015000768

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  • 肺移植患者における腎機能に応じたバルガンシクロビル予防投与の検討

    川西秀明, 村川公央, 北村佳久, 岡田真典, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 千堂年昭

    日本医療薬学会年会講演要旨集   24th   329 - 329   2014.8

  • 呼吸同期‐CTが術前隣接臓器浸潤の評価に有用であった非小細胞肺癌の2例

    渡邉元嗣, 宗淳一, 入江真大, 岡田真典, 三好健太郎, 山本寛斉, 杉本誠一郎, 葉山牧夫, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    岡山医学会雑誌   126 ( 2 )   176 - 176   2014.8

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  • PET/CTで胸腺腫と同時に左腋窩リンパ節にFDGの高集積を認めた1例

    福本侑麻, 杉本誠一郎, 岡田真典, 三好健太郎, 山本寛斉, 宗淳一, 葉山牧夫, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    岡山医学会雑誌   126 ( 2 )   176 - 176   2014.8

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  • 特発性難治性乳び胸の一治験例

    半澤俊哉, 三好健太郎, 原暁生, 杉本誠一郎, 山根正修, 三好新一郎

    岡山医学会雑誌   126 ( 2 )   176   2014.8

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  • 孤立性肺結節影を呈した単中心性Castleman病(形質細胞型)の1例

    岡田 真典, 杉本 誠一郎, 伊賀 徳周, 牧 佑歩, 三好 健太郎, 山本 寛斉, 宗 淳一, 山根 正修, 豊岡 伸一, 大藤 剛宏, 三好 新一郎

    肺癌   54 ( 4 )   254 - 255   2014.8

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  • 肺移植術後の妊娠・出産についての考察

    岡田真典, 伊賀徳周, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本移植学会総会プログラム抄録集   50th   199   2014.8

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  • 骨髄移植後肺GVHDに対する両側生体肺葉移植術後にPassenger Lymphocyte Syndromeを呈した一例

    大亀剛, 杉本誠一郎, 前田嘉信, 伊賀徳周, 岡田真典, 三好健太郎, 山根正修, 大藤剛宏, 三好新一郎

    日本移植学会総会プログラム抄録集   50th   427   2014.8

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  • 肺移植患者の理学療法と当院での現状

    萩山明和, 築山尚司, 福田智美, 岩井賢司, 三好健太郎, 杉本誠一郎, 大藤剛宏

    日本移植学会総会プログラム抄録集   50th   272 - 272   2014.8

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  • 外科研修医に対するシミュレーターを用いた周術期急変時の初期対応評価の試み

    杉本誠一郎, 山根正修, 万代康弘, 大澤晋, 内海方嗣, 豊岡伸一, 大藤剛宏, 三好新一郎

    医学教育   45 ( Suppl. )   130   2014.7

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  • 肺移植患者におけるミコフェノール酸およびそのグルクロン酸抱合代謝物の血漿中濃度に対するUGT1A8の遺伝子多型の影響

    伊藤 雄大, 須野 学, 川西 秀明, 千堂 年昭, 三好 健太郎, 山根 正修, 杉本 誠一郎, 大藤 剛宏

    移植   49 ( 2-3 )   315 - 315   2014.7

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  • 呼吸器外科医育成に求められる質の高い指導医と研修プログラムを目指した取組み

    山根 正修, 岡田 真典, 三好 健太郎, 山本 寛斉, 杉本 誠一郎, 宗 淳一, 葉山 牧夫, 豊岡 伸一, 大藤 剛宏, 三好 新一郎

    日本呼吸器外科学会雑誌   28 ( 3 )   RS5 - 1   2014.4

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  • The Impact of Incomplete Pulmonary Fissures of Living Lobar Lung Transplant Donors on Bronchial Stenosis of Lung Recipients

    S. Sugimoto, T. Oto, M. Okada, K. Miyoshi, A. Nakatani, M. Yamane, S. Miyoshi

    The Journal of Heart and Lung Transplantation   33 ( 4 )   2014.4

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    DOI: 10.1016/j.healun.2014.01.791

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  • 左上葉切除後に生じた気管支狭窄の1例

    葉山牧夫, 三好健太郎, 山本寛斎, 杉本誠一郎, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    気管支学   36   S205   2014.3

  • cN2非小細胞肺癌に対する化学放射線療法後手術療法の成績

    豊岡伸一, 堀田勝幸, 勝井邦彰, 枝園和彦, 宗淳一, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 木浦勝行, 三好新一郎

    日本呼吸器学会誌   3 ( 増刊 )   57 - 57   2014.3

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  • EGFR阻害剤に対する獲得耐性の機構

    豊岡伸一, 枝園和彦, 宗淳一, 山本寛斉, 大塚智昭, 諏澤憲, 橋田真輔, 葉山牧夫, 杉本誠一郎, 山根正修, 大藤剛宏, 木浦勝行, 三好新一郎

    日本呼吸器学会誌   3 ( 増刊 )   23 - 23   2014.3

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  • SY-3-2 最適化医療時代における外科医 : 研究心という剪刀を携える(SY-3 シンポジウム(3)肺癌の個別化医療時代における外科医の役割,第114回日本外科学会定期学術集会)

    豊岡 伸一, 山本 寛斉, 枝園 和彦, 宗 淳一, 葉山 牧夫, 岡田 真典, 三好 健太郎, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 三好 新一郎

    日本外科学会雑誌   115 ( 2 )   124 - 124   2014.3

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  • シミュレーション教育から考える外科医として必要な教育理論と指導者としてのシミュレーション教育効果

    万代康弘, 山根正修, 杉本誠一郎, 浅野博昭, 佃和憲, 三好新一郎

    日本外科学会雑誌   115   449   2014.3

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  • OP-076-1 シミュレーション教育から考える外科医として必要な教育理論と指導者としてのシミュレーション教育効果(OP-076 教育-2,一般演題,第114回日本外科学会定期学術集会)

    万代 康弘, 山根 正修, 杉本 誠一郎, 浅野 博昭, 佃 和憲, 三好 新一郎

    日本外科学会雑誌   115 ( 2 )   449 - 449   2014.3

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  • 最適化医療時代における外科医:研究心という剪刀を携える

    豊岡伸一, 山本寛斉, 枝園和彦, 宗淳一, 葉山牧夫, 岡田真典, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本外科学会雑誌   115 ( 臨増2 )   124 - 124   2014.3

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  • 家族性・孤発性肺腺癌におけるHER2膜貫通領域の新規遺伝子変異

    山本寛斉, 豊岡伸一, 枝園和彦, 橋田真輔, 古川公之, 宗淳一, 岡田真典, 三好健太郎, 杉本誠一郎, 葉山牧夫, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   31st ( 3 )   O17-4 (WEB ONLY) - 4   2014

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  • 術後気管支虚血に対する新たな診断法~Fluorescein induced(Auto) fluorescence imaging technique~

    伊賀徳周, 大藤剛宏, 平野豊, 小西祐輔, 岡田真典, 三好健太郎, 杉本誠一郎, 山根正修, 豊岡伸一, 三好新一郎

    日本呼吸器外科学会総会(Web)   31st   V23-6 (WEB ONLY)   2014

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  • Ex‐vivo lung perfusion臨床導入によるマージナル肺移植の実際

    三好健太郎, 大藤剛宏, 平野豊, 小西祐輔, 伊賀徳周, 岡田真典, 平山伸, 杉本誠一郎, 山根正修, 三好新一郎

    日本呼吸器外科学会総会(Web)   31st   RV8-6 (WEB ONLY)   2014

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  • 若年者女性に発症したMycobacterium avium complex症の一例

    渡邉元嗣, 宗淳一, 入江真大, 岡田真典, 三好健太郎, 山本寛斉, 杉本誠一郎, 葉山牧夫, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   31st ( 3 )   2-P22-10 (WEB ONLY) - 10   2014

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  • 術前3D‐CTで気管支分岐/肺静脈還流異常を診断し,右肺低区域切除を行った多発肺線癌の1例

    宗淳一, 渡邉元嗣, 豊岡伸一, 岡田真典, 枝園和彦, 三好健太郎, 山本寛斉, 杉本誠一郎, 葉山牧夫, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   31st ( 3 )   V9-5 (WEB ONLY) - 5   2014

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  • 慢性関節リウマチに合併した胸腺リンパ濾胞性過形成の1例

    葉山牧夫, 宗淳一, 杉本誠一郎, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本胸腺研究会プログラム・抄録集   33rd   55   2014

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  • 肺移植患者におけるミコフェノール酸およびそのグルクロン酸抱合代謝物の血漿中濃度に対するUGT1A8の遺伝子多型の影響

    伊藤雄大, 須野学, 川西秀明, 千堂年昭, 三好健太郎, 山根正修, 杉本誠一郎, 大藤剛宏

    日本肺および心肺移植研究会プログラム・抄録集   30th   25   2014

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  • Basiliximab inductionの検討

    平野豊, 三好健太郎, 山下里美, 中谷文, 岡田真典, 小西祐輔, 伊賀徳周, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   30th   23   2014

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  • 乳幼児に対する生体肺中葉移植術

    大藤剛宏, 伊賀徳周, 平野豊, 小西祐輔, 岡田真典, 三好健太郎, 杉本誠一郎, 横山千恵, 中谷文, 小林求, 山根正修, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   30th   37   2014

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  • 急性抗体関連型拒絶反応の治験例

    入江真大, 三好健太郎, 山下里美, 中谷文, 岡田真典, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   30th   18   2014

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  • 造血幹細胞移植後肺障害に対する肺移植の予後

    杉本誠一郎, 大藤剛宏, 平野豊, 小西祐輔, 伊賀徳周, 岡田真典, 三好健太郎, 中谷文, 山根正修, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   30th   31   2014

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  • 肺移植後悪性疾患症例の検討

    岡田真典, 大藤剛宏, 中谷文, 平野豊, 小西祐輔, 伊賀徳周, 三好健太郎, 杉本誠一郎, 山根正修, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   30th   22   2014

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  • 肺原発悪性黒色腫の一例

    渡邉元嗣, 宗淳一, 山本寛斉, 入江真大, 岡田真典, 三好健太郎, 杉本誠一郎, 葉山牧夫, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   31st ( 3 )   1-P31-8 (WEB ONLY) - 8   2014

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  • [The role of 18F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) in liposarcoma of the chest wall]

    Yamamoto, H., Sugimoto, S., Miyoshi, K., Yamamoto, H., Soh, J., Yamane, M., Toyooka, S., Oto, T., Miyoshi, S.

    Kyobu geka. The Japanese journal of thoracic surgery   67 ( 1 )   4 - 8   2014

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    18F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT)imaging is valuable in biopsy guidance, response assessment, grading, follow-up and prognostication for soft-tissue sarcoma. In liposarcoma, the maximum standardized uptake value (SUVmax) on PET/CT scan is correlated with the histological subtypes. We briefly review the role of FDG PET/CT in liposarcoma, and describe a case of chest wall liposarcoma treated based on the assessment with PET/CT. A 76-year-old man, with a 10-cm tumor at the thoracic outlet of the right chest wall, underwent the complete resection of the tumor according to the assessment with PET/CT that showed high FDG uptakeonly in the central area of the tumor with SUVmax of 5.89, but low uptake in the peripheral area. In accordance with the PET/CT findings, pathological examination revealed dedifferentiated liposarcoma in the central area and well-differentiated liposarcoma in the peripheral area. Pretherapy PET/CT should be performed for the appropriate treatment of liposarcoma.

    DOI: 10.15106/J00349.2014106921

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  • 肺癌術後の間質性肺炎急性増悪から回復後に発症した難治性気胸に対する1手術例

    岡田真典, 杉本誠一郎, 諏澤憲, 西川仁士, 三好健太郎, 山本寛斉, 宗淳一, 葉山牧夫, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   31st ( 3 )   1-P52-6 (WEB ONLY) - 6   2014

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  • 当院における肺移植の現況と今後の展望―脳死肺葉移植の可能性

    杉本誠一郎, 大藤剛宏, 三好健太郎, 岡田真典, 山本寛斉, 宗淳一, 葉山牧夫, 山根正修, 豊岡伸一, 三好新一郎

    日本呼吸器外科学会総会(Web)   31st ( 3 )   SY2-4 (WEB ONLY) - 4   2014

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  • Fluorescein induced(Auto)fluorescence imaging(FIFI)techniqueを用いた吻合部末梢気管支血流の動的観察

    伊賀徳周, 大藤剛宏, 平野豊, 小西祐輔, 岡田真典, 三好健太郎, 杉本誠一郎, 山根正修, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   30th   24   2014

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  • 術前診断し得た無症候性・機能性後縦隔傍神経節腫の1切除例

    入江 真大, 山本 寛斉, 諏澤 憲, 岡田 真典, 三好 健太郎, 杉本 誠一郎, 宗 淳一, 葉山 牧夫, 山根 正修, 豊岡 伸一, 大藤 剛宏, 三好 新一郎

    肺癌   53 ( 7 )   902 - 902   2013.12

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  • 肺癌術後の間質性肺炎急性増悪から回復後に発症した難治性気胸に対する手術経験

    岡田 真典, 杉本 誠一郎, 諏澤 憲, 西川 仁士, 三好 健太郎, 山本 寛斉, 宗 淳一, 葉山 牧夫, 山根 正修, 豊岡 伸一, 大藤 剛宏, 三好 新一郎

    肺癌   53 ( 7 )   907 - 908   2013.12

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  • 臨床病期N0肺腺癌における潜在的リンパ節転移予測因子の検討

    平野 豊, 宗 淳一, 豊岡 伸一, 三好 健太郎, 山本 寛斉, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 三好 新一郎

    肺癌   53 ( 7 )   901 - 901   2013.12

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  • PERIOPERATIVE NUTRITION OF INDUCTION CHEMORADIOTHERAPY FOLLOWED BY SURGERY IN LOCALLY ADVANCED NON-SMALL LUNG CANCER PATIENTS

    Junichi Soh, Yusuke Konishi, Shinichi Toyooka, Kazuhiko Shien, Hiromasa Yamamoto, Masanori Okada, Kentaroh Miyoshi, Seiichiro Sugimoto, Makio Hayama, Masaomi Yamane, Takahiro Oto, Katsuyuki Kiura, Shinichiro Miyoshi

    JOURNAL OF THORACIC ONCOLOGY   8   S815 - S815   2013.11

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  • EXTENDED SLEEVE LOBECTOMY AFTER INDUCTION CHEMORADIOTHERAPY FOR LOCALLY ADVANCED NON-SMALL CELL LUNG CANCER

    Hiromasa Yamamoto, Shinichi Toyooka, Junichi Soh, Masaomi Yamane, Kazuhiko Shien, Kentaroh Miyoshi, Seiichiro Sugimoto, Takahiro Oto, Shinichiro Miyoshi

    JOURNAL OF THORACIC ONCOLOGY   8   S819 - S819   2013.11

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  • TUMOR ARISING FROM LOWER LOBES IS A POOR PROGNOSTIC FACTOR IN NON-SMALL CELL LUNG CANCER PATIENTS WITH N2 DISEASE TREATED WITH INDUCTION CHEMORADIOTHERAPY

    Ken Suzawa, Shinichi Toyooka, Kazuhiko Shien, Junichi Soh, Hiromasa Yamamoto, Kentaroh Miyoshi, Seiichiro Sugimoto, Masaomi Yamane, Takahiro Oto, Kuniaki Katsui, Katsuyuki Kiura, Shinichiro Miyoshi

    JOURNAL OF THORACIC ONCOLOGY   8   S854 - S854   2013.11

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  • 術前診断し得た後縦隔原発の無症候性かつ機能性傍神経節腫の1切除例

    諏澤憲, 山本寛斉, 岡田真典, 枝園和彦, 三好健太郎, 杉本誠一郎, 宗淳一, 葉山牧夫, 山根正修, 大藤剛宏, 豊岡伸一, 三好新一郎

    日本肺癌学会総会号   54th ( 5 )   655 - 655   2013.10

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  • PET‐CT上縦隔リンパ節転移陽性例における偽陽性関連因子の後方視的検討

    渡邉元嗣, 宗淳一, 三好健太郎, 山本寛斎, 杉本誠一郎, 葉山牧夫, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本肺癌学会総会号   54th ( 5 )   509 - 509   2013.10

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  • 術前導入放射線化学療法を施行した局所進行非小細胞肺癌に対する椎体合併切除術後に気脳症を発症した1例

    杉本誠一郎, 諏澤憲, 西川仁士, 岡田真典, 三好健太郎, 山本寛斉, 宗淳一, 葉山牧夫, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本肺癌学会総会号   54th ( 5 )   676 - 676   2013.10

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  • 分子標的治療と肺癌外科治療―EGFR阻害剤獲得耐性機構とその克服

    豊岡伸一, 枝園和彦, 宗淳一, 山本寛斉, 諏澤憲, 橋田真輔, 葉山牧夫, 杉本誠一郎, 山根正修, 大藤剛宏, 木浦勝行, 三好新一郎

    日本肺癌学会総会号   54th ( 5 )   397 - 397   2013.10

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  • 当科における脳死肺移植待機中のLAM患者の検討

    岡田真典, 大藤剛宏, 中谷文, 平野豊, 小西祐輔, 伊賀徳周, 三好健太郎, 杉本誠一郎, 山根正修, 三好新一郎

    移植   48   285   2013.8

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  • 生体肺移植後のBOSと長期予後における検討

    山根正修, 岡田真典, 三好健太郎, 大谷真二, 杉本誠一郎, 中谷文, 大藤剛宏, 三好新一郎

    移植   48   288   2013.8

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  • 1年5カ月の長期人工呼吸管理後に脳死両肺移植が可能であった閉塞性細気管支炎の一例

    原暁生, 大藤剛宏, 田中孝幸, 中谷文, 三好健太郎, 杉本誠一郎, 山根正修, 三好新一郎

    移植   48   410   2013.8

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  • 肺移植後遠隔期合併症とその管理

    三好健太郎, 中谷文, 岡田真典, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    移植   48   186   2013.8

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  • 肺移植の現況―小児肺移植の現状と課題―

    大藤剛宏, 岡田真典, 中谷文, 三好健太郎, 杉本誠一郎, 山根正修, 三好新一郎

    移植   48   190   2013.8

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  • 肺移植後の気管支合併症に対する治療方針

    杉本誠一郎, 大藤剛宏, 三好健太郎, 岡田真典, 中谷文, 山根正修, 三好新一郎

    移植   48   250   2013.8

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  • 長期間のEpoprostenol療法後に脳死両側肺移植を施行した1例

    平野豊, 三好健太郎, 大藤剛宏, 中谷文, 杉本誠一郎, 山根正修, 三好新一郎

    移植   48   411   2013.8

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  • 多数の具体的達成・評価項目票使用による診療参加型臨床実習の導入

    山根 正修, 杉本 誠一郎, 宗 淳一, 万代 康弘, 三好 健太郎, 山本 寛斉, 豊岡 伸一, 大藤 剛宏, 三好 新一郎

    医学教育   44 ( Suppl. )   110 - 110   2013.7

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  • Autofluorescence Imaging(AFI)気管支鏡を用いた気道虚血障害の評価

    伊賀徳周, 大藤剛宏, 岡田真典, 西川仁士, 三好健太郎, 杉本誠一郎, 山根正修, 豊岡伸一, 三好新一郎

    気管支学   35   S115   2013.5

  • 術前PET検査が有用であった胸壁原発脂肪肉腫の一例

    山本治慎, 杉本誠一郎, 三好健太郎, 山本寛斉, 宗淳一, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    岡山医学会雑誌   125 ( 1 )   91 - 91   2013.4

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  • 巨大縦隔脂肪肉腫の1切除例

    平野豊, 山本寛斉, 豊岡伸一, 西川仁士, 三好健太郎, 杉本誠一郎, 宗淳一, 山根正修, 大藤剛宏, 三好新一郎

    岡山医学会雑誌   125 ( 1 )   91 - 91   2013.4

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  • MAPK/ERK Pathway Activation Leads to Severe Ischemia-Reperfusion-Induced Lung Injury

    M. Okada, M. Yamane, N. Iga, H. Nishikawa, S. Yamamoto, S. Otani, N. Waki, S. Hirayama, K. Miyoshi, S. Sugimoto, S. Toyooka, T. Oto, A. Matsukawa, S. Miyoshi

    The Journal of Heart and Lung Transplantation   32 ( 4 )   2013.4

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    DOI: 10.1016/j.healun.2013.01.309

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  • Lung Transplantation for Diffuse Panbronchiolitis

    S. Sugimoto, T. Oto, K. Miyoshi, H. Nishikawa, A. Nakatani, M. Yamane, S. Miyoshi

    The Journal of Heart and Lung Transplantation   32 ( 4 )   2013.4

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    DOI: 10.1016/j.healun.2013.01.456

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  • 移植医療を日常診療に―理想的なチーム医療体制の構築に向けて

    山根正修, 西川仁士, 大谷真二, 三好健太郎, 杉本誠一郎, 宗淳一, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本外科学会雑誌   114 ( 臨増2 )   331 - 331   2013.3

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  • WS-15-2 移植医療を日常診療に : 理想的なチーム医療体制の構築に向けて(WS ワークショップ,第113回日本外科学会定期学術集会)

    山根 正修, 西川 仁士, 大谷 真二, 三好 健太郎, 杉本 誠一郎, 宗 淳一, 豊岡 伸一, 大藤 剛宏, 三好 新一郎

    日本外科学会雑誌   114 ( 2 )   331 - 331   2013.3

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  • 局所進行非小細胞癌に対する導入化学放射線療法後肺切除術における周術期栄養状態の検討

    小西祐輔, 宗淳子, 豊岡伸一, 諏澤憲, 平野豊, 山本寛斎, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 木浦勝行, 三好新一郎

    静脈経腸栄養   28 ( 1 )   462 - 462   2013.1

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  • 術前診断し得た無症候性・機能性後縦隔傍神経節腫の1切除例

    入江真大, 山本寛斉, 諏澤憲, 岡田真典, 三好健太郎, 杉本誠一郎, 宗淳一, 葉山牧夫, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    肺癌(Web)   53 ( 7 )   902(J-STAGE)   2013

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  • 臨床病期I期非小細胞肺癌における潜在的リンパ節転移の予測因子の検討

    平野豊, 宗淳一, 豊岡伸一, 西川仁士, 三好健太郎, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   30th ( 3 )   P08-02 (WEB ONLY) - 02   2013

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  • 肺癌術後の間質性肺炎急性増悪から回復後に発症した難治性気胸に対する手術経験

    岡田真典, 杉本誠一郎, 諏澤憲, 西川仁士, 三好健太郎, 山本寛斉, 宗淳一, 葉山牧夫, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    肺癌(Web)   53 ( 7 )   907-908(J-STAGE)   2013

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  • びまん性汎細気管支炎に対する肺移植

    杉本誠一郎, 大藤剛宏, 三好健太郎, 西川仁士, 山本寛斉, 宗淳一, 山根正修, 豊岡伸一, 三好新一郎

    日本呼吸器外科学会総会(Web)   30th ( 3 )   P56-10 (WEB ONLY) - 10   2013

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  • 一側肺移植における仰臥位Semi‐clamshell approach

    三好健太郎, 大藤剛宏, 山本寛斉, 杉本誠一郎, 宗淳一, 山根正修, 豊岡伸一, 三好新一郎

    日本呼吸器外科学会総会(Web)   30th ( 3 )   V14-01 (WEB ONLY) - 01   2013

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  • 導入化学放射線療法後に左下葉・舌区スリーブ切除術を施行した局所進行左下葉原発肺癌の3例

    宗淳一, 豊岡伸一, 山本寛斉, 枝園和彦, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   30th ( 3 )   P15-07 (WEB ONLY) - 07   2013

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  • 非小細胞肺癌に対する導入化学放射線療法後の拡大スリーブ切除術の予後

    豊岡伸一, 宗淳一, 山本寛斉, 西川仁士, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   30th ( 3 )   P15-06 (WEB ONLY) - 06   2013

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  • 喀血を繰り返し,完全鏡視下上大区域切除により治療的診断を行った肺嚢胞内出血の1例

    小西祐輔, 宗淳一, 豊岡伸一, 平野豊, 諏澤憲, 西川仁士, 三好健太郎, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   30th ( 3 )   P59-06 (WEB ONLY) - 06   2013

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  • 巨大縦隔脂肪肉腫に対してClamshell切開に下部胸骨正中切開を加えることで切除可能であった1例

    平野豊, 山本寛斉, 豊岡伸一, 西川仁士, 三好健太郎, 杉本誠一郎, 宗淳一, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   30th ( 3 )   P81-09 (WEB ONLY) - 09   2013

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  • 肺摘除後無瘻性膿胸に対する容易な閉創を企図した小開窓法

    西川仁士, 三好健太郎, 小西祐輔, 山本寛斉, 杉本誠一郎, 宗淳一, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   30th ( 3 )   P73-01 (WEB ONLY) - 01   2013

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  • 稀な組織型の胸壁腫瘍の一例

    山本寛斉, 豊岡伸一, 宗淳一, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   30th ( 3 )   P62-09 (WEB ONLY) - 09   2013

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  • 臨床病期N0肺腺癌における潜在的リンパ節転移予測因子の検討

    平野豊, 宗淳一, 豊岡伸一, 三好健太郎, 山本寛斉, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    肺癌(Web)   53 ( 7 )   901(J-STAGE)   2013

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  • Unilateral Lung Transplantation Using Bilateral Upper Lobes: Experimental Study

    H. Nishikawa, T. Oto, S. Otani, M. Harada, N. Iga, M. Okada, S. Hirayama, K. Miyoshi, S. Sugimoto, M. Yamane, S. Toyooka, S. Miyoshi

    TRANSPLANTATION   94 ( 10 )   938 - 938   2012.11

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  • 胸腺原発MALTリンパ腫の1切除例

    諏澤憲, 杉本誠一郎, 豊岡伸一, 平野豊, 小西祐輔, 三好健太郎, 山本寛斉, 宗淳一, 山根正修, 大藤剛宏, 三好新一郎

    肺癌   52 ( 5 )   703 - 703   2012.10

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  • 縦隔リンパ節転移陽性Stage III期非小細胞肺癌に対する治療

    豊岡伸一, 木浦勝行, 勝井邦彰, 宗淳一, 枝園和彦, 山本寛斉, 三好健太郎, 杉本誠一郎, 久本晃子, 山根正修, 大藤剛宏, 伊達洋至, 金澤右, 三好新一郎

    肺癌   52 ( 5 )   505 - 505   2012.10

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  • 導入療法後肺門部局所進行肺癌切除における全摘回避の工夫―健常部自家肺移植の有用性

    三好健太郎, 大藤剛宏, 平山伸, 山本寛斉, 杉本誠一郎, 宗淳一, 山根正修, 豊岡伸一, 三好新一郎

    肺癌   52 ( 5 )   572 - 572   2012.10

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  • 転移性肺腫瘍に対しラジオ波焼灼療法試行後に難治性皮下・縦隔気腫を呈した一例

    小西祐輔, 山本寛斉, 平木隆夫, 宗淳一, 豊岡伸一, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 金澤右, 三好新一郎

    肺癌   52 ( 5 )   585 - 585   2012.10

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  • 重粒子線(炭素イオン線)治療を施行されたIA期非小細胞肺癌の局所再発に対する手術経験

    杉本誠一郎, 豊岡伸一, 諏澤憲, 西江尚貴, 三好健太郎, 山本寛斉, 宗淳一, 山根正修, 大藤剛宏, 三好新一郎

    肺癌   52 ( 5 )   563 - 563   2012.10

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  • 微小乳頭状肺腺癌におけるEGFR、K-ras、EML4-ALKの変異の様式(EGFR, K-ras and EML4-ALK mutational profile of lung adenocarcinomas with micropapillary component)

    古川 公之, 宗 淳一, 豊岡 伸一, 枝園 和彦, 三好 健太郎, 山本 寛斉, 杉本 誠一郎, 山根 正修, 大藤 剛宏, 三好 新一郎

    肺癌   52 ( 5 )   671 - 671   2012.10

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  • AFI bronchoscopyを用いたairway ischemic damage評価の有用性

    伊賀徳周, 大藤剛宏, 岡田真典, 西川仁士, 原田昌明, 三好健太郎, 大谷真二, 平山伸, 杉本誠一郎, 山根正修, 豊岡伸一, 三好新一郎

    Gen Thorac Cardiovasc Surg   60 ( Supplement )   503   2012.9

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  • 局所進行肺癌に対する導入化学放射線療法後スリーブ肺葉切除術の成績と工夫

    豊岡伸一, 宗淳一, 山本寛斉, 枝園和彦, 三好健太郎, 杉本誠一郎, 平山伸, 山根正修, 大藤剛宏, 伊達洋至, 三好新一郎

    Gen Thorac Cardiovasc Surg   60 ( Supplement )   275   2012.9

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  • 肺細胞傷害後に放出される細胞外ATPによる腕移植後のTh17依存性拒絶反応

    杉本誠一郎, GELMAN Andrew E, 山本澄治, 三好健太郎, 山根正修, 大藤剛宏, 三好新一郎

    Gen Thorac Cardiovasc Surg   60 ( Supplement )   498   2012.9

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  • 当院における最新の呼吸器外科周術期管理―周術期管理センター(PERIO)導入の効果―

    宗淳一, 豊岡伸一, 山本寛斉, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    Gen Thorac Cardiovasc Surg   60 ( Supplement )   710   2012.9

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  • Extended criteria lungはどこまで使用可能なのか―ドナー・レシピエント双方のスコアリング分析に基づく考察

    三好健太郎, 大藤剛宏, 大谷真二, 杉本誠一郎, 山根正修, 豊岡伸一, 三好新一郎

    Gen Thorac Cardiovasc Surg   60 ( Supplement )   493   2012.9

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  • 当院における肺移植待機患者の管理と往診の取り組み

    中谷文, 大藤剛宏, 山根正修, 杉本誠一郎, 三好健太郎, 三好新一郎

    移植   47   270   2012.9

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  • シェーグレン症候群に伴う多発嚢胞性肺病変に対し肺移植が有効であった1例

    木村紘爾, 山根正修, 平山伸, 平野豊, 三好健太郎, 杉本誠一郎, 豊岡伸一, 大藤剛宏, 三好新一郎

    移植   47   295   2012.9

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  • 繰り返す両側気胸を伴う症例における片肺移植開胸法の工夫

    諏澤憲, 杉本誠一郎, 三好健太郎, 中谷文, 山根正修, 大藤剛宏, 三好新一郎

    移植   47   295   2012.9

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  • 肺移植後のタクロリムス経静脈投与法の有用性

    杉本誠一郎, 大藤剛宏, 諏澤憲, 中谷文, 三好健太郎, 山根正修, 三好新一郎

    移植   47   282   2012.9

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  • 左下葉原発肺癌に対し,術前導入化学放射線療法後に左下葉・舌区スリーブ切除術を施行した1例

    山本寛斉, 豊岡伸一, 宗淳一, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    肺癌   52 ( 4 )   450 - 450   2012.8

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  • 肺癌の肺内転移と鑑別を要した肺クリプトコッカス症の1例

    諏澤憲, 杉本誠一郎, 三好健太郎, 山本寛斉, 宗淳一, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    肺癌   52 ( 4 )   453 - 454   2012.8

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  • 左2nd carinaを含めた気管支楔状切除により肺切除を回避し得た気管支カルチノイドの1切除例

    山本寛斉, 豊岡伸一, 宗淳一, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    気管支学   34 ( 4 )   403 - 403   2012.7

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  • 642 Neutrophil Elastase Inhibitor Improves Lung Function during Ex Vivo Lung Perfusion

    M. Harada, T. Oto, M. Okada, H. Nishikawa, N. Iga, K. Miyoshi, S. Otani, S. Sugimoto, M. Yamane, S. Miyoshi

    The Journal of Heart and Lung Transplantation   31 ( 4 )   S221 - S222   2012.4

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    DOI: 10.1016/j.healun.2012.01.656

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  • 142 Fifteen-Year Experience of Living Donor Lobar Lung Transplant: Update on the Outcomes and Pulmonary Function of Recipients

    M. Yamane, M. Yoshikawa, K. Miyoshi, S. Sugimoto, T. Oto, S. Miyoshi

    The Journal of Heart and Lung Transplantation   31 ( 4 )   S56 - S57   2012.4

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    DOI: 10.1016/j.healun.2012.01.146

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  • 16 Release of ATP by Injured Pulmonary Cells Triggers Th17 Dependent Lung Allograft Rejection

    S. Sugimoto, D. Kreisel, A.S. Krupnick, A.E. Gelman

    The Journal of Heart and Lung Transplantation   31 ( 4 )   2012.4

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    DOI: 10.1016/j.healun.2012.01.019

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  • 530 Detection of Post Lung Transplant Airway Ischemia Using Autofluorescence Imaging (AFI) Bronchoscopy

    I. Norichika, T. Oto, M. Okada, H. Masaaki, H. Nisikawa, K. Miyoshi, S. Otani, S. Sugimoto, M. Yamane, S. Toyooka, S. Miyoshi

    The Journal of Heart and Lung Transplantation   31 ( 4 )   2012.4

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    DOI: 10.1016/j.healun.2012.01.542

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  • 局所進行非小細胞肺癌に対する術前放射線同時併用化学療法後の肺切除の成績と周術期管理の工夫

    豊岡伸一, 宗淳一, 牧佑歩, 上野剛, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本外科学会雑誌   113 ( 臨増2 )   211 - 211   2012.3

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  • 非小細胞肺癌に対する根治的放射線化学療法後手術の治療成績

    宗淳一, 豊岡伸一, 枝園和彦, 三好健太郎, 上野剛, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本外科学会雑誌   113 ( 臨増2 )   803 - 803   2012.3

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  • 術前放射線化学療法後に前・後方アプローチにより根治術を行った肺尖部胸壁浸潤肺癌の1例

    杉本誠一郎, 豊岡伸一, 宗淳一, 鹿谷芳伸, 下田篤史, 山根正修, 大藤剛宏, 三好新一郎, 武本充宏, 木浦勝行

    肺癌   52 ( 1 )   109 - 110   2012.2

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  • 悪性中皮腫が原因と考えられるネフローゼ症候群に対し胸膜肺全摘を施行し改善した1例

    下田篤史, 豊岡伸一, 大澤昌宏, 宗淳一, 杉本誠一郎, 鹿谷芳伸, 山根正修, 大藤剛宏, 三好新一郎

    肺癌   52 ( 1 )   115 - 116   2012.2

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  • 術前導入化学放射線療法後,気管支形成を伴う右上葉切除,頚部・縦隔リンパ節郭清を施行した肺癌1例

    鹿谷芳伸, 豊岡伸一, 宗淳一, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎, 武本充宏, 木浦勝行

    肺癌   52 ( 1 )   120 - 120   2012.2

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  • 腫瘍原発部位はN2非小細胞肺癌に対する導入化学放射線治療後手術療法の予後因子である

    難波圭, 豊岡伸一, 枝園和彦, 宗淳一, 勝井邦彰, 山本寛斉, 三好健太郎, 杉本誠一郎, 久本晃子, 山根正修, 大藤剛宏, 金澤右, 木浦勝行, 三好新一郎

    日本癌治療学会学術集会(CD-ROM)   50th ( 3 )   ROMBUNNO.PS2-021 - 2125   2012

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  • Erdheim‐Chester diseaseによる間質性肺炎に対する肺移植の一例

    橋本好平, 水谷尚雄, 河本純一, 山根正修, 三好健太郎, 杉本誠一郎, 中谷文, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   29th   O06-02 (WEB ONLY)   2012

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  • 両側上葉を用いた左片肺移植の実験的検討

    西川仁士, 大藤剛宏, 岡田真典, 伊賀徳周, 原田昌明, 三好健太郎, 大谷真二, 杉本誠一郎, 山根正修, 豊岡伸一, 三好新一郎

    日本呼吸器外科学会総会(Web)   29th   O07-05 (WEB ONLY)   2012

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  • 肺移植後Posterior leukoencephalopathy syndrome発症例におけるタクロリムス徐放剤による免疫抑制管理

    三好健太郎, 大藤剛宏, 上野剛, 杉本誠一郎, 山根正修, 三好新一郎

    日本呼吸器外科学会総会(Web)   29th   O07-04 (WEB ONLY)   2012

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  • 甲状腺癌気管浸潤に対し,6cm長の気管切除を施行した1例

    豊岡伸一, 平成人, 宗淳一, 山本寛斉, 黒崎毅史, 三好健太郎, 上野剛, 杉本誠一郎, 平山伸, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   29th ( 3 )   V09-02 (WEB ONLY) - 02   2012

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  • 左上下葉気管支分岐部楔状切除を行った気管支カルチノイドの一切除例

    中田憲太郎, 山本寛斉, 豊岡伸一, 宗淳一, 上野剛, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   29th ( 3 )   P55-06 (WEB ONLY) - 06   2012

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  • 肺切除後心房細動例の検討

    山本治慎, 三好健太郎, 山本寛斎, 杉本誠一郎, 宗淳一, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   29th ( 3 )   P75-01 (WEB ONLY) - 01   2012

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  • 臓器移植法改正前後での脳死肺移植症例の比較検討

    杉本誠一郎, 大藤剛宏, 三好健太郎, 山本寛斉, 宗淳一, 山根正修, 豊岡伸一, 三好新一郎

    日本呼吸器外科学会総会(Web)   29th ( 3 )   RS08-03 (WEB ONLY) - 03   2012

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  • 非喫煙者肺腺癌におけるNFKBIA遺伝子発現の検討

    古川公之, 宗淳一, 豊岡伸一, 市村浩一, 枝園和彦, 牧佑歩, 村岡孝幸, 田中則光, 上野剛, 山本寛斎, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   29th ( 3 )   RS06-01 (WEB ONLY) - 01   2012

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  • 生体肺移植後の長期予後と呼吸機能の推移における検討

    山根正修, 吉川真生, 岡田真典, 伊賀徳周, 原田昌明, 西川仁士, 平山伸, 三好健太郎, 大谷真二, 杉本誠一郎, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   29th ( 3 )   O06-05 (WEB ONLY) - 05   2012

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  • 生体肺移植後閉塞性細肺気管支炎症候群(BOS)症例における呼吸機能と長期予後の検討

    吉川真生, 山根正修, 岡田真典, 伊賀徳周, 原田昌明, 西川仁士, 平山伸, 三好健太郎, 大谷真二, 杉本誠一郎, 中谷文, 大藤剛宏, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   28th   29   2012

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  • 虚血再灌流肺障害にはMAPK経路の活性化が関与する

    岡田真典, 山根正修, 伊賀徳周, 原田昌明, 西川仁士, 平山伸, 山本澄治, 脇直久, 三好健太郎, 大谷真二, 杉本誠一郎, 宗淳一, 豊岡伸一, 大藤剛宏, 松川昭博, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   28th   15   2012

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  • PK/PD理論に基づいたMRSA膿胸に対するArbekacin局所洗浄療法

    上野剛, 豊岡伸一, 黒崎毅史, 平山伸, 三好健太郎, 山本寛斉, 杉本誠一郎, 宗淳一, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   29th ( 3 )   P38-03 (WEB ONLY) - 03   2012

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  • 血清中microRNA34b/cメチル化同定による悪性胸膜中皮腫高感度スクリーニング法

    村岡孝幸, 宗淳一, 豊岡伸一, 枝園和彦, 古川公之, 牧佑歩, 上野剛, 山本寛斉, 青江啓介, 藤本伸一, 岸本卓巳, 大槻剛巳, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   29th ( 3 )   RS06-03 (WEB ONLY) - 03   2012

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  • Autofluorescence Imaging(AFI) bronchoscopyを用いたair way ischemic damageの評価

    伊賀徳周, 大藤剛宏, 岡田真典, 西川仁士, 原田昌明, 三好健太郎, 大谷真二, 杉本誠一郎, 山根正修, 豊岡伸一, 三好新一郎

    日本呼吸器外科学会総会(Web)   29th   RS07-02 (WEB ONLY)   2012

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  • 肺移植後気管支吻合部狭窄に対する血管用ステント留置術

    上野剛, 大藤剛宏, 山根正修, 平山伸, 三好健太郎, 山本寛斉, 杉本誠一郎, 宗淳一, 豊岡伸一, 三好新一郎

    日本呼吸器外科学会総会(Web)   29th ( 3 )   V19-02 (WEB ONLY) - 02   2012

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  • 岡山大学病院呼吸器外科における冠動脈ステント留置症例に対する周術期管理

    黒崎毅史, 豊岡伸一, 山本寛斎, 三好健太郎, 上野剛, 杉本誠一郎, 平山伸, 宗淳一, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会総会(Web)   29th ( 3 )   O23-03 (WEB ONLY) - 03   2012

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  • [Primary mediastinal lymphoma; a clinicopathologic case series].

    Sugimoto, S., Soh, J., Maki, Y., Kurosaki, T., Yamane, M., Toyooka, S., Oto, T., Miyoshi, S.

    Kyobu geka. The Japanese journal of thoracic surgery   65 ( 7 )   527 - 31   2012

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    Treatment for primary mediastinal lymphoma generally involves chemotherapy and radiotherapy, and treatment regimens depend on histologic subtypes of lymphoma. The histologic subtype of lymphoma is mostly determined by computed tomography (CT)-guided core-needle biopsy or surgical procedures, including thoracotomy, thoracoscopy and mediastinoscopy. We describe the clinicopathologic features and diagnostic procedures of 8 cases of primary mediastinal lymphoma. The male-to-female ratio was 1:1, and median age at diagnosis was 27 years. The median size of the primary mediastinal tumor on CT was 8.5 cm. Five patients were diagnosed by CT-guided core-needle biopsy, 1 by open biopsy and 2 by surgery. Three patients were diagnosed with nodular sclerosis Hodgkin lymphoma, 3 with mediastinal diffuse large B-cell lymphoma, 1 with precursor T-lymphoblastic leukemia/lymphoma and 1 with thymic extranodal marginal zone B-cell lymphoma. According to their histological subtypes, 5 patients were treated with chemoradiotherapy, 2 patients with chemotherapy and 1 patient of thymic extranodal marginal zone B-cell lymphoma with surgery alone. All patients survived in the median follow-up of 34.5 months. Appropriate biopsy procedure should be performed in patients with suspected mediastinal lymphoma.

    DOI: 10.15106/J00349.2012314022

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  • マージナルドナー肺の右下葉切除術後に脳死両側肺移植を施行した1例

    黒崎毅史, 杉本誠一郎, 三好健太郎, 平山伸, 中谷文, 山根正修, 大藤剛宏, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   28th   35   2012

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  • マージナルドナー肺による片肺移植の1例

    林優子, 山根正修, 上野剛, 平山伸, 三好健太郎, 大谷真二, 杉本誠一郎, 中谷文, 大藤剛宏, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   28th   34   2012

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  • Erdheim‐Chester diseaseによる間質性肺炎に対する肺移植の一例

    橋本好平, 水谷尚雄, 河本純一, 山根正修, 三好健太郎, 杉本誠一郎, 中谷文, 大藤剛宏, 三好新一郎

    日本肺および心肺移植研究会プログラム・抄録集   28th   33   2012

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  • 局所進行非小細胞肺癌に対する集学的治療の成績と今後の展望

    豊岡伸一, 木浦勝行, 勝井邦彰, 宗淳一, 枝園和彦, 山本寛斉, 三好健太郎, 杉本誠一郎, 久本晃子, 山根正修, 大藤剛宏, 伊達洋至, 金澤右, 三好新一郎

    日本癌治療学会学術集会(CD-ROM)   50th ( 3 )   ROMBUNNO.S03-4 - 608   2012

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  • 腎細胞癌の縦隔リンパ節転移による右主気管支狭窄に対して気管支動脈塞栓術後の気管支ステント留置が有効であった一例

    佐藤博紀, 杉本誠一郎, 黒崎毅史, 三好健太郎, 上野剛, 宗淳一, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本臨床外科学会雑誌   72 ( 増刊 )   745 - 745   2011.10

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  • 当院における重症筋無力症に対する鏡視下拡大胸腺摘出術

    宗淳一, 豊岡伸一, 林達朗, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    肺癌   51 ( 5 )   581 - 581   2011.10

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  • 縦隔悪性リンパ腫症例の検討

    杉本誠一郎, 宗淳一, 黒崎毅史, 佐藤博紀, 三浦章博, 牧佑歩, 三好健太郎, 上野剛, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    肺癌   51 ( 5 )   507 - 507   2011.10

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  • 縦隔リンパ節転移陽性非小細胞肺癌に対する導入化学放射線治療後手術療法の長期成績

    豊岡伸一, 宗淳一, 枝園和彦, 上野剛, 三好健太郎, 杉本誠一郎, 山根正修, 大藤剛宏, 武本充広, 堀田勝幸, 田端雅弘, 木浦勝行, 伊達洋至, 三好新一郎

    肺癌   51 ( 5 )   361 - 361   2011.10

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  • 当科における閉塞性肺疾患に対する肺移植の検討

    岡田真典, 大藤剛宏, 伊賀徳周, 原田昌明, 西川仁士, 三好健太郎, 大谷真二, 杉本誠一郎, 山根正修, 三好新一郎

    移植   46   196   2011.10

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  • 両側生体肺移植後5年以上経過した症例のBOSに関する検討

    杉本誠一郎, 大藤剛宏, 三好健太郎, 大谷真二, 岡田真典, 伊賀徳周, 原田昌明, 西川仁士, 山根正修, 三好新一郎

    移植   46   133   2011.10

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  • 両側脳死肺移植後の創離開に対して持続陰圧吸引法(VAC療法)が有効であった一例

    佐藤博紀, 杉本誠一郎, 黒崎毅史, 三好健太郎, 上野剛, 宗淳一, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    移植   46 ( 総会臨時 )   300 - 300   2011.10

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  • ブタ肺移植で使用している体外肺評価システム中還流液にエラスポールを加えた場合の有効性の検討

    原田昌明, 大藤剛宏, 岡田真典, 伊賀徳周, 西川仁志, 三好健太郎, 大谷真二, 杉本誠一郎, 山根正修, 三好新一郎

    移植   46   300   2011.10

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  • 電球色照明下における有彩色文章の読みやすさ

    桜井将人, 杉本誠一郎, 澁谷大志, 山本栄

    照明学会全国大会講演論文集   44th   178   2011.9

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  • SPREAD2ノックアウトマウスを用いた異所性気管移植モデルにおける慢性拒絶反応

    原翔平, 山根正修, 脇直久, 杉本誠一郎, 大藤剛宏, 三好新一郎

    移植   46 ( 4/5 )   381   2011.9

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  • 肺移植後閉胸困難症例の管理にEsmarch Bandagesが有用であった3例

    二萬英斗, 大藤剛宏, 大谷真二, 杉本誠一郎, 山根正修, 宗淳一, 三好新一郎

    移植   46 ( 4/5 )   385 - 385   2011.9

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  • 原発性肺癌に対する術中迅速リンパ節診断に基づく縮小リンパ節郭清の妥当性

    枝園和彦, 豊岡伸一, 宗淳一, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    General Thoracic and Cardiovascular Surgery   59 ( Supplement )   521   2011.9

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  • 導入療法後切除N2非小細胞肺癌症例における予後因子としての癌幹細胞関連マーカー

    枝園和彦, 豊岡伸一, 宗淳一, 杉本誠一郎, 山根正修, 大藤剛宏, 武本充広, 木浦勝行, 三好新一郎

    Gen Thorac Cardiovasc Surg   59 ( Supplement )   486   2011.9

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  • ドナー評価に関して

    山根正修, 大藤剛宏, 三好健太郎, 大谷真二, 青景圭樹, 杉本誠一郎, 宗淳一, 豊岡伸一, 三好新一郎

    移植   46 ( 4/5 )   386 - 386   2011.9

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  • 本邦初のBOS肺に対する再肺移植としての生体肺葉移植の経験

    大谷真二, 大藤剛宏, 宗淳一, 岡田真典, 西川仁志, 伊賀徳周, 牧佑歩, 青景圭樹, 杉本誠一郎, 山根正修, 豊岡伸一, 三好新一郎

    Gen Thorac Cardiovasc Surg   59 ( Supplement )   542   2011.9

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  • 本邦初のBOS肺に対する再肺移植の経験

    大谷真二, 大藤剛宏, 宗淳一, 伊賀徳周, 青景圭樹, 杉本誠一郎, 山根正修, 豊岡伸一, 三好新一郎

    移植   46 ( 4/5 )   384 - 385   2011.9

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  • 肺実質切離時におけるVessel sealing system(LigaSure)の有用性

    杉本誠一郎, 豊岡伸一, 伊賀徳周, 古川公之, 杉本龍士郎, 田中真, 枝園和彦, 西川仁士, 三好健太郎, 上野剛, 宗淳一, 山根正修, 大藤剛宏, 三好新一郎

    Gen Thorac Cardiovasc Surg   59 ( Supplement )   590   2011.9

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  • 当院におけるGVHD肺病変の治療

    田中真, 大藤剛宏, 三好健太郎, 大谷真二, 杉本誠一郎, 宗淳一, 山根正修, 豊岡伸一, 三好新一郎

    移植   46 ( 4/5 )   388 - 388   2011.9

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  • 本邦における肺移植における脳死ドナー肺の評価に関する検討と現状

    山根正修, 三好健太郎, 伊賀徳周, 原田昌明, 西川仁志, 岡田昌典, 杉本誠一郎, 豊岡伸一, 大藤剛宏, 三好新一郎

    Gen Thorac Cardiovasc Surg   59 ( Supplement )   509   2011.9

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  • 腎細胞癌の縦隔リンパ節転移による気道狭窄に対して気管支動脈塞栓術後のステント留置が有効であった1例

    佐藤博紀, 杉本誠一郎, 黒崎毅史, 三好健太郎, 上野剛, 宗淳一, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    肺癌   51 ( 4 )   310 - 310   2011.8

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  • 当科で経験した前縦隔悪性リンパ腫8例の検討

    杉本誠一郎, 宗淳一, 黒崎毅史, 佐藤博紀, 三浦章博, 牧佑歩, 三好健太郎, 上野剛, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    肺癌   51 ( 4 )   308 - 308   2011.8

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  • 第一肋骨線維性骨異形成の1切除例

    古川公之, 宗淳一, 豊岡伸一, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    肺癌   51 ( 4 )   313 - 314   2011.8

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  • COPDの集学的治療 肺移植

    大藤剛宏, 岡田真典, 伊賀徳周, 原田昌明, 西川仁士, 三好健太郎, 大谷真二, 杉本誠一郎, 宗淳一, 中谷文, 山根正修, 豊岡伸一, 三好新一郎

    日本気胸・嚢胞性肺疾患学会雑誌   11 ( 2 )   80 - 80   2011.8

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  • 当科におけるCOPDに対する肺移植治療経験

    岡田真典, 大藤剛宏, 伊賀徳周, 原田昌明, 西川仁士, 三好健太郎, 大谷真二, 宗淳一, 杉本誠一郎, 山根正修, 豊岡伸一, 三好新一郎

    日本気胸・嚢胞性肺疾患学会雑誌   11 ( 2 )   110 - 110   2011.8

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  • IS-7-4 Living-donor-lobar lung transplantation : A practical option for pediatric lung transplant candidates in Japan(IS-7 Pediatric transplantation : International consensus and future in Japan)

    Oto Takahiro

    Journal of Japan Surgical Society   112 ( 1 )   2011.5

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  • 術前放射線化学療法後に気管および気管支形成術により肺全摘を回避し得たT4(気管,気管分岐部浸潤)肺癌の2例

    伊賀徳周, 豊岡伸一, 大谷真二, 青景圭樹, 杉本誠一郎, 宗淳一, 山根正修, 大藤剛宏, 三好新一郎

    気管支学   33 ( 3 )   204 - 204   2011.5

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  • Pediatric transplantation:International consensus and future in Japan 小児肺移植における生体肺葉移植の位置づけ(Pediatric transplantation: International consensus and future in Japan Living-donor-lobar lung transplantation: A practical option for pediatric lung transplant candidates in Japan)

    大藤 剛宏, 山根 正修, 伊達 洋至, 南 正人, 白石 武史, 杉本 誠一郎, 青景 圭樹, 原田 昌明, 伊賀 徳周, 西川 仁士, 岡田 真典, 大谷 真二, 三好 健太郎, 脇 直久, 宗 淳一, 豊岡 伸一, 三好 新一郎

    日本外科学会雑誌   112 ( 臨増1-2 )   197 - 197   2011.5

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  • 上大静脈進展腫瘍に対する当科における手術アプローチ

    伊賀徳周, 宗淳一, 古川公之, 大谷真二, 青景圭樹, 杉本誠一郎, 山根正修, 豊岡伸一, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会雑誌   25 ( 3(Web) )   V01-04 (WEB ONLY) - 04   2011.4

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  • ラジオ波焼灼療法後に遅発性血気胸を発症した大腸癌肺転移の1例

    宗淳一, 豊岡伸一, 郷原英夫, 大谷真二, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会雑誌   25 ( 3(Web) )   P45-07 (WEB ONLY) - 07   2011.4

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  • 長期間の経過で増大した肺硬化性血管腫の1例

    村岡孝幸, 豊岡伸一, 伊賀徳周, 牧祐歩, 古川公之, 原田昌明, 三好健太郎, 上野剛, 大谷真二, 青景圭樹, 杉本誠一郎, 西川仁士, 宗淳一, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会雑誌   25 ( 3(Web) )   P40-04 (WEB ONLY) - 04   2011.4

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  • ブタモデルにおける区域肺動脈内色素注入による肺区域間面同定法

    杉本誠一郎, 大藤剛宏, 二萬英斗, 三好健太郎, 万代康弘, 澤田芳行, 大谷真二, 青景圭樹, 宗淳一, 山根正修, 豊岡伸一, 三好新一郎

    日本呼吸器外科学会雑誌   25 ( 3(Web) )   P25-01 (WEB ONLY) - 01   2011.4

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  • IKK beta in recipient myeloid cells promotes lung allograft acceptance and prevents the accumulation of intragraft IL-17(+) CD4(+) T cells

    Howard Huang, Sumiharu Yamamoto, Seiichiro Sugimoto, Jihong Zhu, Alexander Krupnick, Daniel Kreisel, Andrew Gelman

    JOURNAL OF IMMUNOLOGY   186   2011.4

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  • 23 Effect of Donor Premortem Hypoxia and Hypotension on Graft Function and Start of Warm Ischemia in Donation after Cardiac Death Lung Transplantation

    K. Miyoshi, T. Oto, S. Otani, S. Tanaka, M. Harada, T. Kakishita, S. Hori, S. Sugimoto, M. Yamane, S. Miyoshi

    The Journal of Heart and Lung Transplantation   30 ( 4 )   S15 - S16   2011.4

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    DOI: 10.1016/j.healun.2011.01.030

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  • 心臓死肺移植

    大藤剛宏, 宗淳一, 杉本誠一郎, 大谷真二, 三好健太郎, 脇直久, 山根正修, 豊岡伸一, 三好新一郎

    Gen Thorac Cardiovasc Surg   58 ( Supplement )   206   2010.10

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  • 特発性間質性肺炎に対する生体肺移植

    三好健太郎, 大藤剛宏, 杉本誠一郎, 宗淳一, 山根正修, 豊岡伸一, 三好新一郎

    移植   45 ( 5 )   538 - 539   2010.10

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  • 治療抵抗性特発性間質性肺炎に対する生体肺移植の治療成績

    三好健太郎, 大藤剛宏, 杉本誠一郎, 宗淳一, 山根正修, 豊岡伸一, 三好新一郎

    Gen Thorac Cardiovasc Surg   58 ( Supplement )   326   2010.10

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  • 局所進行肺癌に対する,横切開併用胸骨正中切開による肺切除術の検討

    牧佑歩, 豊岡伸一, 大谷真二, 青景圭樹, 杉本誠一郎, 宗淳一, 山根正修, 大藤剛宏, 三好新一郎

    Gen Thorac Cardiovasc Surg   58 ( Supplement )   587   2010.10

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  • 骨髄細胞IκBキナーゼβの欠損による肺移植後免疫寛容の導入阻害

    杉本誠一郎, HUANG Howard J, 岡崎幹生, 脇直久, 三好健太郎, 大谷真二, 原田昌明, 山根正修, 大藤剛宏, PATTERSON G Alexander, KREISEL Daniel, GELMAN Andrew E, 三好新一郎

    Gen Thorac Cardiovasc Surg   58 ( Supplement )   434   2010.10

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  • 高齢者肺癌に対する術後合併症の予防―より安全な外科療法を目指して―

    牧佑歩, 豊岡伸一, 大谷真二, 青景圭樹, 杉本誠一郎, 宗淳一, 山根正修, 大藤剛宏, 三好新一郎

    肺癌   50 ( 5 )   554 - 554   2010.10

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  • 胸膜肺全摘術によりネフローゼ症候群の改善を得た悪性胸膜中皮腫の1例

    宗淳一, 豊岡伸一, 牧佑歩, 杉本誠一郎, 山根正修, 大藤剛宏, 三好新一郎

    肺癌   50 ( 5 )   564 - 564   2010.10

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  • 初回手術後12年目に肺転移をきたし胸膜中皮腫との鑑別を要した滑膜肉腫の1例

    杉本誠一郎, 豊岡伸一, 下田篤史, 鹿谷芳伸, 大谷真二, 青景圭樹, 宗淳一, 山根正修, 大藤剛宏, 三好新一郎

    肺癌   50 ( 5 )   651 - 651   2010.10

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  • 転移性肺腫瘍との鑑別に難渋した肺硬化性血管腫の1例

    村岡孝幸, 豊岡伸一, 牧佑歩, 伊賀徳周, 古川公之, 原田昌明, 上野剛, 三好健太郎, 大谷真二, 青景圭樹, 杉本誠一郎, 宗淳一, 山根正修, 大藤剛宏, 三好新一郎

    肺癌   50 ( 5 )   721 - 721   2010.10

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  • 薄切CT評価によるcT1bN0原発性肺腺癌における選択的リンパ節郭清の可能性

    青景圭樹, 豊岡伸一, 杉本誠一郎, 宗淳一, 山根正修, 大藤剛宏, 三好新一郎

    肺癌   50 ( 5 )   537 - 537   2010.10

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  • 当院における胸腺腫手術症例の変遷

    下田篤史, 豊岡伸一, 宗淳一, 杉本誠一郎, 山根正修, 三好新一郎

    肺癌   50 ( 5 )   565 - 565   2010.10

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  • ハイリスク肺移植におけるbasiliximab induction therapyの検討

    大藤剛宏, 山根正修, 杉本誠一郎, 三好健太郎, 大谷真二, 原田昌明, 脇直久, 三好新一郎

    移植   45   198   2010.10

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  • 改訂臓器移植法施行後における生体肺移植の位置づけ:脳死下臓器提供で十分か?

    大藤剛宏, 山根正修, 杉本誠一郎, 三好健太郎, 脇直久, 大谷真二, 原田昌明, 鈴木智恵, 犬飼倫子, 岩崎光亜, 山田有香, 西岡麻衣, 中谷文, 横山千恵, 角南直美, 三好新一郎

    移植   45   148   2010.10

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  • 緊急顆粒球形成による移植肺の生着阻害

    杉本誠一郎, 岡崎幹生, 脇直久, 三好健太郎, 大谷真二, 原田昌明, 山根正修, 大藤剛宏, PATTERSON G Alexander, KREISEL Daniel, GELMAN Andrew E, 三好新一郎

    移植   45 ( 総会臨時 )   200 - 200   2010.10

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  • 心臓死肺移植ドナーにおける死戦期のグラフト障害因子とドナー適応判断豚肺移植モデルでの検討

    三好健太郎, 大藤剛宏, 原田昌明, 大谷真二, 脇直久, 杉本誠一郎, 山根正修, 三好新一郎

    移植   45   199   2010.10

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  • 当院における軟骨肉腫の臨床病理学的検討―胸壁原発例・肺転移例を中心に―

    宗淳一, 豊岡伸一, 牧佑歩, 杉本誠一郎, 原田昌明, 村岡孝幸, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会雑誌   24 ( 3 )   481 - 481   2010.4

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  • Bcl‐3はマウス肺移植後の虚血再還流障害を負に制御する

    杉本誠一郎, 岡崎幹生, GELMAN Andrew E, KREISEL Daniel, 三好新一郎

    日本呼吸器外科学会雑誌   24 ( 3 )   417 - 417   2010.4

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  • 高齢者社会における安全な呼吸器外科手術‐周術期センター開設による新しい取り組み‐

    牧佑歩, 豊岡伸一, 宗淳一, 杉本誠一郎, 村岡孝幸, 原田昌明, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会雑誌   24 ( 3 )   424 - 424   2010.4

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  • 単発腫瘤にて発症した肺ランゲルハンス組織球腫の1例

    村岡孝幸, 豊岡伸一, 牧祐歩, 原田昌明, 杉本誠一郎, 宗淳一, 山根正修, 大藤剛宏, 三好新一郎

    日本呼吸器外科学会雑誌   24 ( 3 )   459 - 459   2010.4

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  • 原発性肺高血圧症に対する生体肺移植レシピエントの管理―心機能の観点から―

    豊岡伸一, 大藤剛宏, 山根正修, 杉本誠一郎, 宗淳一, 石原恵, 伊達洋至, 三好新一郎

    日本呼吸器外科学会雑誌   24 ( 3 )   373 - 373   2010.4

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  • マウス肺移植後のグラフト障害におけるBcl3の役割―緊急の顆粒球形成の抑制による肺保護効果

    杉本誠一郎, 岡崎幹生, PATTERSON G Alexander, KREISEL Daniel, GELMAN Andrew E, 三好新一郎

    日本外科学会雑誌   111 ( 臨増2 )   648 - 648   2010.3

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  • 503: Does the Ex-Vivo Lung Evaluation System Affect Post-Transplant Graft Function in Swine Donation after Cardiac Death (DCD) Lung Transplantation?

    S. Otani, T. Oto, K. Miyoshi, S. Yamamoto, T. Kakishita, M. Okazaki, O. Yoshida, N. Waki, S. Hori, S. Sugimoto

    The Journal of Heart and Lung Transplantation   29 ( 2 )   S164 - S164   2010.2

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    DOI: 10.1016/j.healun.2009.11.520

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  • 肺移植後の虚血再灌流障害におけるIKKβの役割

    杉本誠一郎, HUANG Howard J, 岡崎幹生, PATTERSON G. Alexander, KREISEL Daniel, GELMAN Andrew E, 三好新一郎

    Gen Thorac Cardiovasc Surg   57 ( Supplement )   411   2009.9

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  • Costimulatory blockadeによる肺移植後免疫寛容とその阻害因子

    岡崎幹生, 杉本誠一郎, 山根正修, 豊岡伸一, 大藤剛宏, 佐野由文, 三好新一郎, KREISEL Daniel

    移植   44 ( 総会臨時 )   313 - 313   2009.9

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  • マウス肺移植後の急性拒絶反応におけるCD8+T細胞の役割

    杉本誠一郎, 岡崎幹生, PATTERSON G Alexander, GELMAN Andrew E, KREISEL Daniel, 三好新一郎

    移植   44 ( 総会臨時 )   312 - 312   2009.9

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  • Bc13 protects against lung graft injury by limiting emergency granulopoiesis

    Seiichiro Sugimoto, Daniel Kreisel, Ruaihdrhi Carmody, Andrew E. Gelman

    JOURNAL OF IMMUNOLOGY   182   2009.4

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  • 137: OX40 Triggering Breaks Costimulation Blockade-Mediated Lung Allograft Acceptance

    M. Okazaki, W. Li, J. Lai, S. Sugimoto, C.G. Kornfeld, F.H. Kreisel, X. Lin, G.A. Patterson, A.S. Krupnick, A.E. Gelman, D. Kreisel

    The Journal of Heart and Lung Transplantation   28 ( 2 )   2009.2

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    DOI: 10.1016/j.healun.2008.11.815

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  • 274: Deletion of Inhibitoryκ Kinase β from Myeloid Cells Prevents Induction of Mouse Lung Allograft Acceptance

    H. Huang, S. Sugimoto, G.A. Patterson, S.A. Krupnick, D. Kreisel, A.E. Gelman

    The Journal of Heart and Lung Transplantation   28 ( 2 )   S161 - S162   2009.2

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    DOI: 10.1016/j.healun.2008.11.281

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  • Emergency Granulopoiesis Prevents Lung Allograft Acceptance.

    Wenjun Li, Seiichiro Sugimoto, Jihong Zhu, Alexander S. Krupnick, Daniel Kreisel, Andrew E. Gelman

    AMERICAN JOURNAL OF TRANSPLANTATION   9   210 - 210   2009

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  • Granulocytes Activated by Lung Transplantation Stimulate Dendritic Cell Maturation and CD4+T Cell Th1 Polarization

    Yvette M. Carter, Seiichiro Sugimoto, Jihong Zhu, Alexander S. Krupnick, Daniel Kreisel, Andrew E. Gelman

    AMERICAN JOURNAL OF TRANSPLANTATION   9   397 - 397   2009

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  • Costimulatory blockadeによるCD4+Foxp3+制御性T細胞の移植肺への集積と急性拒絶反応の抑制

    岡崎幹生, 杉本誠一郎, 山根正修, 豊岡伸一, 大藤剛宏, 佐野由文, GELMAN Andrew E, KREISEL Daniel

    Gen Thorac Cardiovasc Surg   56 ( Supplement )   248   2008.9

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  • 肺急性拒絶反応におけるCCR2の役割

    岡崎幹生, 杉本誠一郎, 山根正修, 豊岡伸一, 大藤剛宏, 佐野由文

    移植   43 ( 総会臨時 )   396 - 396   2008.9

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  • The IkB family member Bcl-3 regulates lung graft inflammation and injury

    Andrew E. Gelman, Daniel Kreisel, Seiichiro Sugimoto, Jeremy Tietjens

    FASEB JOURNAL   22   2008.4

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  • 30: CCR2 Is Required for Monocyte Recruitment and Differentiation but Not Acute Rejection of Vascularized Mouse Lung Allografts

    M. Okazaki, S. Sugimoto, J. Lai, C.G. Kornfeld, J.R. Tietjens, S.B. Richardson, H.J. Huang, A. Patterson, A.S. Krupnick, A.E. Gelman, D. Kreisel

    The Journal of Heart and Lung Transplantation   27 ( 2 )   S70 - S71   2008.2

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    DOI: 10.1016/j.healun.2007.11.034

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  • 28: Maintenance of Canonical I-κB Kinase Activity Is Required To Prevent Lung Graft Injury

    H.J. Huang, S. Sugimoto, J. Lai, N.A. Das, M. Okazaki, G.A. Patterson, D. Kreisel, A.E. Gelman

    The Journal of Heart and Lung Transplantation   27 ( 2 )   2008.2

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    DOI: 10.1016/j.healun.2007.11.032

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  • 130: Costimulatory Blockade Leads to Accumulation of Antigen-Specific CD4+Foxp3+ Regulatory T Cells in Vascularized Mouse Lung Allografts and Prevents Their Acute Rejection

    Seiichiro Sugimoto

    The Journal of Heart and Lung Transplantation   2008.2

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  • 439: Bcl-3 Negatively Regulates Ischemia Reperfusion Injury in Mouse Orthotopic Vascularized Lung Grafts

    S. Sugimoto, J. Lai, M. Okazaki, R. Carmody, H.J. Huang, G.A. Patterson, D. Kreisel, A.E. Gelman

    The Journal of Heart and Lung Transplantation   27 ( 2 )   2008.2

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    DOI: 10.1016/j.healun.2007.11.451

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  • 同所性マウス肺移植後の急性拒絶反応におけるCD4陽性T細胞の役割と共刺激阻害剤の有効性の検討

    岡崎幹生, 杉本誠一郎, ALEXANDER Patterson G, ANDREW Gelman, DANIEL Kreisel

    移植   42 ( 総会臨時 )   177 - 177   2007.10

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  • 心臓死ドナー(NHBD)に対する,blood flushを用いたグラフト機能評価法の有用性についての検討

    堀志郎, 山根正修, 柿下大一, 吉田修, 杉本龍士郎, 杉本誠一郎, 大藤剛宏, 佐野由文, 伊達洋至

    移植   42 ( 総会臨時 )   243 - 243   2007.10

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  • Bilateral native lung-sparing lobar transplantation in a canine model.

    杉本誠一郎

    岡山医学会雑誌   119 ( 2 )   218   2007.9

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  • イヌ実験モデルにおける両側生体肺部分移植(原標題は英語)

    杉本誠一郎, 伊達洋至, 杉本龍士郎, 吉田修, 山根正修, 豊岡伸一, 青江基, 佐野由文

    Jpn J Thorac Cardiovasc Surg   54   323   2006.9

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  • 両側生体部分肺移植5年後に再発を認めた肺リンパ脈管筋腫症の一例

    杉本龍士郎, 伊達洋至, 杉本誠一郎, 吉田修, 山根正修, 豊岡伸一, 青江基, 岡崎恵, 佐野由文

    移植   41   320   2006.9

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  • 新しい生体肺移植術式bilateral native lung sparing lobar transplantationの慢性期評価と合併症

    杉本誠一郎, 伊達洋至, 杉本龍士郎, 岡崎恵, 吉田修, 山根正修, 豊岡伸一, 青江基, 佐野由文

    移植   41   200   2006.9

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  • 当院における肺移植後の気道系合併症の検討

    青江基, 平見有二, 重松久之, 山根正修, 豊岡伸一, 佐野由文, 吉田修, 杉本誠一郎, 杉本龍士郎, 岡崎恵, 伊達洋至

    Jpn J Thorac Cardiovasc Surg   54 ( Suppl. )   321 - 321   2006.9

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  • イヌモデルにおける両側生体肺部分移植(Bilateral Native Lung Sparing Lobar Transplantation in a Canine Model)

    杉本 誠一郎, 伊達 洋至, 杉本 龍士郎, 吉田 修, 山根 正修, 豊岡 伸一, 青江 基, 佐野 由文

    The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY   54 ( Suppl. )   323 - 323   2006.9

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  • OKT3が有用であった生体肺移植後のステロイド抵抗性急性拒絶反応の検討

    杉本誠一郎, 伊達洋至, 杉本龍士郎, 吉田修, 豊岡伸一, 青江基, 岡部和倫, 佐野由文

    日本呼吸器外科学会雑誌   20 ( 3 )   812 - 812   2006.5

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  • 新しい生体肺移植術式bilateral native lung sparing lobar transplantationの急性期評価

    杉本誠一郎, 伊達洋至, 杉本龍士郎, 吉田修, 青江基, 佐野由文

    日本外科学会雑誌   107 ( 臨増2 )   195 - 195   2006.3

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  • 両側生体部分肺移植後に肺リンパ脈管筋腫症再発を来たした一例

    杉本龍士郎, 伊達洋至, 杉本誠一郎, 青江基, 豊岡伸一, 岡部和倫, 岡崎恵, 佐野由文

    移植   41 ( 1 )   57 - 58   2006.2

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  • 両側自己肺温存肺部分移植術(NLSLT)の可能性

    杉本誠一郎, 伊達洋至, 杉本龍士郎, 岡崎恵, 吉田修, 青江基, 佐野由文

    移植   41 ( 1 )   55 - 55   2006.2

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  • Seven-year experience in living-donor lobar lung transplantation

    H. Date, M. Aoe, M. Okazaki, R. Sugimoto, S. Sugimoto, K. Goto, Y. Sano

    JOURNAL OF HEART AND LUNG TRANSPLANTATION   25 ( 2 )   S113 - S114   2006.2

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  • The technique of bilateral native lung sparing lobar transplantation in a canine model

    S. Sugimoto, H. Date, R. Sugimoto, M. Aoe, Y. Sano

    JOURNAL OF HEART AND LUNG TRANSPLANTATION   25 ( 2 )   S163 - S164   2006.2

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  • 人工呼吸器管理中の患者に対する生体肺移植の経験

    伊達 洋至, 青江 基, 佐野 由文, 杉本 誠一郎, 杉本 龍士郎, 岡崎 恵, 清水 信義

    移植   40 ( 総会臨時 )   279 - 279   2005.10

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  • 新しい生体肺移植術式bilateral native lung sparing lobar transplantationの開発

    杉本誠一郎

    移植   40 ( 総会臨時 )   278 - 278   2005.10

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  • 犬死体肺移植における心マッサージによるヘパリン,ウロキナーゼ投与の効果の検討

    杉本 龍士郎, 伊達 洋至, 杉本 誠一郎, 岡崎 恵, 青江 基, 佐野 由文, 清水 信義

    移植   40 ( 総会臨時 )   327 - 327   2005.10

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  • 直腸癌術後縫合不全による吻合部離開に対J型回腸嚢間置術を施行した1例

    杉本誠一郎, 内藤稔, 宗淳一, 伊野英男, 村上正和, 清水信義

    岡山医学会雑誌   117 ( 2 )   167 - 167   2005.9

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  • 両側生体部分肺移植後に生じた肺ろうに対し局所麻酔・硬膜外麻酔下にVATS閉鎖術を施行した1例

    杉本誠一郎, 永広格, 伊達洋至, 青江基, 佐野由文, 清水信義

    Jpn J Thorac Cardiovasc Surg   53   56   2005.3

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  • すい仮性嚢胞破裂による腹腔内出血の1例

    杉本誠一郎, 村上正和, 市原周治, 永広格, 内藤稔, 清水信義, 太田徹哉

    岡山医学会雑誌   116 ( 3 )   317   2005.1

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  • 甲状腺MALTリンパ腫の3切除例

    杉本誠一郎, 小笠原豊, 土井原博義, 清水信義

    甲状腺外科研究会   37回   150 - 150   2004.10

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  • 腹腔内出血をきたしたすい仮性嚢胞の1例

    杉本誠一郎, 村上正和, 市原周治, 永広格, 内藤稔, 清水信義, 太田徹哉

    日本臨床外科学会雑誌   65   635   2004.9

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  • 乳房温存療法後に発症したBOOP様肺炎の3例

    杉本誠一郎, 土井原博義, 小笠原豊, 清水信義

    日本臨床外科学会雑誌   65   542   2004.9

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  • 低位前方切除術後約3年を経過し発症した特発性大腸穿孔の1例

    杉本誠一郎, 村上正和, 内藤稔

    日本大腸こう門病学会雑誌   57 ( 9 )   748   2004.9

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  • OKT3が著効した両側生体部分肺移植後のステロイド抵抗性急性拒絶反応の1例

    杉本誠一郎, 伊達洋至, 永広格, 青江基, 佐野由文, 清水信義

    移植   39   350   2004.9

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  • 肺癌術後気管支断端ろうに対して,フィブリン糊の粘膜下注入で閉鎖し得た1例

    徳毛誠樹, 永広格, 杉本誠一郎, 田尾裕之, 源寛二, 板野秀樹, 青江基, 佐野由文, 伊達洋至

    日本呼吸器外科学会雑誌   18 ( 3 )   377 - 377   2004.4

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  • 両側生体部分肺移植後,開胸肺生検にて確定診断しえた急性拒絶反応の1例

    杉本誠一郎, 永広格, 伊達洋至, 青江基, 佐野由文, 清水信義

    日本呼吸器外科学会雑誌   18 ( 3 )   389 - 389   2004.4

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  • 胸壁切除術にて診断の確定した甲状腺乳頭癌肋骨転移の1例

    杉本誠一郎, 永広格, 青江基, 佐野由文, 伊達洋至, 清水信義

    日本呼吸器外科学会雑誌   18 ( 3 )   430 - 430   2004.4

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  • 術後創感染との鑑別が困難であった肺癌区域切除後限局性MRSA膿胸の一例

    水谷尚雄, 杉本誠一郎, 萱野公一, 寺本滋

    日本呼吸器外科学会雑誌   17 ( 3 )   342 - 342   2003.4

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  • 内視鏡下甲状腺良性腫瘍摘出術症例の検討

    萱野 公一, 杉本 誠一郎, 水谷 尚雄, 古城 資久, 西岡 聖

    甲状腺外科研究会   35回   112 - 112   2002.11

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  • 大綱充填術を施行した吻合部潰よう穿孔の1例

    杉本誠一郎, 萱野公一, 水谷尚雄, 古城資久, 宮崎医津博, 長尾俊彦, 西岡聖, 内田発三

    日本臨床外科学会雑誌   63 ( 増刊 )   357 - 357   2002.10

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  • 最近経験した非外傷性小腸穿孔の3例

    杉本誠一郎, 萱野公一, 水谷尚雄, 古城資久, 宮崎医津博, 西岡聖

    日本消化器外科学会雑誌   34 ( 7 )   1142 - 1142   2001.7

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  • へん平上皮癌を混在したlarge cell neuroendocrine carcinoma(LCNEC)の1例

    杉本誠一郎, 水谷尚雄, 萱野公一, 寺本滋

    日本呼吸器外科学会雑誌   15 ( 3 )   397 - 397   2001.4

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    J-GLOBAL

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  • 肺原発large cell neuroendocrine carcinomaの1例

    杉本誠一郎, 中野秀治, 三竿貴彦, 神野禎次, 多胡護, 山根正隆, 中川準平

    Jpn J Thorac Cardiovasc Surg   49 ( Suppl. )   135 - 135   2001.3

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  • 著明な石灰化を伴った縦隔嚢胞の2例

    杉本誠一郎, 中野秀治, 堀志郎, 高橋三奈, 小林成行, 中川準平, 三竿貴彦

    日本呼吸器外科学会雑誌   14 ( 3 )   452 - 452   2000.4

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  • 肝転移再発胃癌の臨床病理学的検討

    小野田 裕士, 泉 貞言, 杉本 誠一郎, 鈴鹿 伊智雄, 多胡 護, 塩田 邦彦, 山根 正隆, 中川 準平

    日本臨床外科学会雑誌   60 ( 増刊 )   494 - 494   1999.10

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  • 術前診断に苦慮した脾リンパ管腫の1例

    杉本 誠一郎, 小野田 裕士, 泉 貞言, 鈴鹿 伊智雄, 多胡 護, 塩田 邦彦, 山根 正隆, 中川 準平

    日本臨床外科学会雑誌   60 ( 増刊 )   392 - 392   1999.10

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  • 当院における乳房Paget病6例の検討

    岡 智, 三竿 貴彦, 中村 光次, 堀 志郎, 杉本 誠一郎, 森田 英幹, 鈴木 宏光, 田尾 裕之, 泉 貞言, 小野田 裕士

    香川県医師会誌   52 ( 特別 )   63 - 63   1999.8

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  • 両側巨大気腫性肺嚢胞症に対し胸腔鏡下手術を施行した2例

    鈴木 宏光, 中野 秀治, 三竿 貴彦, 杉本 誠一郎, 堀 志郎, 田尾 裕之, 中川 準平

    日本呼吸器外科学会雑誌   13 ( 3 )   428 - 428   1999.4

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  • 残胃癌22例の臨床病理学的検討

    田尾 裕之, 泉 貞言, 杉本 誠一郎, 堀 志郎, 鈴木 宏光, 小野田 裕士, 鈴鹿 伊智雄, 神野 禎次, 中野 秀治, 多胡 護

    日本消化器外科学会雑誌   32 ( 2 )   688 - 688   1999.2

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Awards

  • 第119回 日本外科学会定期学術集会 優秀演題賞

    2019.4  

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  • 岡山大学大学院医歯薬学総合研究科 Best Clinical Facilitator賞

    2018.5  

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  • 岡山大学大学院医歯薬学総合研究科 教育功労賞

    2014.1  

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  • The International Society for Heart and Lung Transplantation/Research Fellowship Grant Award 国際心肺移植学会研究奨励賞

    2008.4  

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  • 平成18年度 岡山医学会賞(砂田賞)

    2007.6  

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  • 第14回 岡山大学第二外科・心臓血管外科 同門会長賞

    2006.11  

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Research Projects

  • ナノポアシーケンサーを用いた移植肺障害の革新的な迅速診断法の開発と病態解明

    Grant number:23KK0154  2023.09 - 2027.03

    日本学術振興会  科学研究費助成事業  国際共同研究加速基金(海外連携研究)

    杉本 誠一郎, 大谷 真二, 橋本 好平, 三好 健太郎

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    Grant amount:\20930000 ( Direct expense: \16100000 、 Indirect expense:\4830000 )

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  • Identification of genetic loci associated with chronic lung allograft dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array

    Grant number:23K08294  2023.04 - 2026.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    富岡 泰章, 冨田 秀太, 豊岡 伸一, 杉本 誠一郎

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    Grant amount:\4810000 ( Direct expense: \3700000 、 Indirect expense:\1110000 )

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  • 同種造血細胞移植後閉塞性細気管支炎におけるマクロファージ標的治療の開発

    Grant number:23K07627  2023.04 - 2026.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    藤井 伸治, 遠西 大輔, 豊岡 伸一, 杉本 誠一郎, 藤原 英晃, 清家 圭介

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    Grant amount:\4550000 ( Direct expense: \3500000 、 Indirect expense:\1050000 )

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  • 空間マルチオミックスを用いた慢性肺GVHDとの比較による慢性移植肺機能不全の病態解明

    Grant number:23K08295  2023.04 - 2026.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    松原 慧, 橋本 好平, 豊岡 伸一, 遠西 大輔, 杉本 誠一郎, 田中 真, 岡崎 幹生, 三好 健太郎, 藤井 伸治

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    Grant amount:\4550000 ( Direct expense: \3500000 、 Indirect expense:\1050000 )

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  • ヤンセンファーマ株式会社契約研究助成2023

    2023.01 - 2023.12

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  • 抗炎症タンパク質HRGに着眼した肺虚血再灌流障害に対する新規治療法の開発

    Grant number:22K08974  2022.04 - 2025.03

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    杉本 誠一郎, 豊岡 伸一, 岡崎 幹生, 逢坂 大樹

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    Grant amount:\4160000 ( Direct expense: \3200000 、 Indirect expense:\960000 )

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  • In-vivo lung perfusion as a novel treatment strategy for primary graft dysfunction after lung transplantation

    Grant number:21K08882  2021.04 - 2024.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    三好 健太郎, 杉本 誠一郎, 岡崎 幹生

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    Grant amount:\4290000 ( Direct expense: \3300000 、 Indirect expense:\990000 )

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  • 肺虚血再灌流障害におけるS100A8/A9の役割の解明と新しい治療法の開発

    Grant number:20K09164  2020.04 - 2023.03

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    岡崎 幹生, 大谷 真二, 山根 正修, 坂上 倫久, 豊岡 伸一, 山本 寛斉, 木下 理恵, 杉本 誠一郎, 阪口 政清

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    Grant amount:\4290000 ( Direct expense: \3300000 、 Indirect expense:\990000 )

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  • 組織障害性HMGB1に着眼した肺虚血再灌流障害に対する新規戦略の確立

    Grant number:20K09176  2020.04 - 2023.03

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    大谷 真二, 山根 正修, 豊岡 伸一, 杉本 誠一郎, 王 登莉, 西堀 正洋, 岡崎 幹生, 三好 健太郎, 阪口 政清

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    Grant amount:\4290000 ( Direct expense: \3300000 、 Indirect expense:\990000 )

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  • マイクロ波焼灼術の豚肺を用いた基礎研究ー肺癌患者への適応拡大に向けてー

    Grant number:19K08227  2019.04 - 2022.03

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    生口 俊浩, 金澤 右, 平木 隆夫, 松井 裕輔, 冨田 晃司, 杉本 誠一郎, 都地 友紘

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    Grant amount:\4290000 ( Direct expense: \3300000 、 Indirect expense:\990000 )

    厚生労働省から発表された「平成29年(2017)人口動態統計(確定数)」によると日本人の死因の1位は「悪性新生物(がん)」であり、その中でも男女共に肺癌が1位となっている。原発性肺癌の標準治療は手術であるが早期肺癌であっても様々な理由から20%以上の患者は手術を施行できない。治療選択の限られている肺癌患者に新たな治療法を確立することは多くの患者が恩恵を受けるだけでなく、肺癌が死因1位のがんの中でも最多である我が国において大変重要な意味を持つ。
    肝臓癌に対する経皮的局所療法としてラジオ波焼灼術(RFA)が一般的に行われているがマイクロ波焼灼術(MWA)はRFAより強力であるため焼灼時間が短い、より大きな焼灼範囲を得られる、火傷の危険がないなどRFAにはない多くの利点がある。我々は肺癌にMWAを行うことで、RFAよりも大きな癌の治療が可能、1回の治療でより多くの癌の治療が可能、RFAより短時間での治療が可能など患者の恩恵が増すと考えた。
    本研究の目的は肺癌患者にMWA施行するにあたり明確にすべき点を動物実験にて解決することである。肺癌患者に対してMWAを行うにはまずは動物実験にて焼灼プロトコールの確立、肺動・静脈や気管支によるheat sink effectの影響の検証が必要であるため、平成31年度は焼灼実験のプロトコールを作成して倫理委員会へ申請し、申請許可を得た。
    次年度は動物実験を行い、「動物実験手技」「画像的分析」「組織的分析」を経て肺癌に対するプロトコールの確立を目指す。

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  • ジャポニカアレイを応用した肺移植後慢性拒絶反応の新しい診断法の開発

    Grant number:19K09305  2019.04 - 2022.03

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    杉本 誠一郎, 豊岡 伸一, 大藤 剛宏

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    Grant amount:\4420000 ( Direct expense: \3400000 、 Indirect expense:\1020000 )

    肺移植後の慢性拒絶反応である慢性移植肺機能不全(CLAD)は、肺移植後の長期生存を低下させる主な原因であり、移植後5年で約半数の患者がCLADを発症する。CLADは発症早期の治療介入により増悪を防止できる可能性があるが、現在の診断方法は呼吸機能に基づいており、早期診断が困難なため、早期診断を可能にする新しいバイオマーカーが必要とされている。我々はこれまでに、生体肺移植のドナーとレシピエントの一塩基多型(SNP)の違いから、レシピエント血中のドナー由来DNAを検出し、急性拒絶反応の新しい診断方法になりうることを報告した。しかし、限られたSNPの解析では、ドナーとレシピエントのDNAの類似性から診断が困難な場合があり、それを克服する新たな技術が必要であった。一方、ジャポニカアレイでは多量のSNPを微量の検体から安価に解析できるため、本研究ではジャポニカアレイを用いて、レシピエント血中のドナー由来DNAを測定し、肺移植後のCLADにおける新しい早期診断方法の開発を目的とした。本年度は、これまでに当院で保存された血液検体を用いて、ジャポニカアレイによる解析を試みた。しかし、ジャポニカアレイの解析では、従来の研究よりも多くのDNA量が必要とされ、保存された血液検体ではジャポニカアレイの解析に必要なDNA量が不足していることが判明した。このため、本年度に新たに施行した生体肺移植の症例から、ジャポニカアレイで必要とされるDNA量を満たした血液検体の保存方法に変更し、この血液検体を用いて、ジャポニカアレイによる約60万種のSNPを網羅的に解析し、標的SNPの同定を行った。予想通り、以前の解析方法に比べ、簡便に標的SNPを同定することが可能であったため、今後、レシピエント血中のドナー由来DNAを測定し、肺移植後CLADにおける新しい早期診断方法になりえるか、その可能性を検討していく。

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  • Novel lung preservation technique for organ donor with broad atelectasis

    Grant number:17K10785  2017.04 - 2020.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Miyoshi Kentaroh

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    Grant amount:\4680000 ( Direct expense: \3600000 、 Indirect expense:\1080000 )

    Brain-dead donor is susceptible to pulmonary atelectasis. In procurement surgery for lung transplantation, lung recruitment under circulatory condition and cold flush procedures for atelectatic donor lungs often provoke graft injury and primary graft dysfunction.We hypothesized that acirculatory lung recruitment (ALR) can mitigate the lung injury. The ALR can be performed by recruitment maneuver following aortic clamp in donor surgery. We examined the benefit of ALR using an animal transplant model.
    PaO2/FiO2 ratio after lung retrieval by ALR and transplantation showed significantly higher than conventional method.ALR was proven to be more protective for lung graft than conventional procurement procedure.

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  • ノバルティスファーマ研究助成

    2016

    ノバルティスファーマ研究助成 

    杉本誠一郎

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  • Donor-derived cell-free DNA is associated with acute rejection and decreased oxygenation in primary graft dysfunction after living donor-lobar lung transplantation

    Grant number:15K10256  2015.04 - 2018.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Sugimoto Seiichiro, OTO Takahiro, TOYOOKA Shinichi, TANAKA Shin

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    Grant amount:\4810000 ( Direct expense: \3700000 、 Indirect expense:\1110000 )

    Donor-derived cell-free DNA (dd-cf-DNA) has been shown to be an informative biomarker of rejection after lung transplantation (LT) from deceased donors. However, in living-donor lobar LT (LDLLT), because small grafts are implanted with short ischemic time from blood-relatives, the detection of dd-cf-DNA might be challenging. Our study was aimed to examine the role of dd-cf-DNA in the early phase after LDLLT. Immediately after LDLLT, the dd-cf-DNA levels were highly elevated, subsequently reaching the plateau, with the resolution of primary graft dysfunction (PGD). Increased levels of dd-cf-DNA significantly correlated with decreased oxygenation immediately and 72 hours after LDLLT. The dd-cf-DNA levels significantly increased in the patients with acute rejection than in those with infection or stable condition. The measurement of dd-cf-DNA might be useful to monitor the severity of PGD, and dd-cf-DNA could be a potential biomarker for the diagnosis of acute rejection after LDLLT.

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  • 肺移植後の虚血再灌流障害と移植肺生着阻害における制御機構の解明

    2014

    日本学術振興会藤田記念医学研究振興基金研究助成事業 

    杉本誠一郎

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  • 岡山大学若手研究者スタートアップ研究支援事業

    2013 - 2014

    岡山大学  岡山大学若手研究者スタートアップ研究支援事業 

    杉本誠一郎

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  • The mechanism of ischemia reperfusion injury and abrogation of lung allograft acceptance after lung transplantation

    Grant number:24791461  2012.04 - 2014.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    SUGIMOTO Seiichiro

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    Grant amount:\4290000 ( Direct expense: \3300000 、 Indirect expense:\990000 )

    Outcomes after lung transplantation remain significantly worse than those after transplantation of other solid organs. Ischemia reperfusion injury is the leading cause for early morbidity and mortality after lung transplantation and has also been shown to be a risk factor for chronic lung rejection demonstrating its long-term effect on allografts. In this study, we examined the mechanism of ischemia reperfusion injury and abrogation of lung allograft acceptance after lung transplantation.

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  • Ischemia reperfusion injury induced abrogation of lung transplant acceptance

    Grant number:22791251  2010 - 2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)  Grant-in-Aid for Young Scientists (B)

    SUGIMOTO Seiichiro

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    Grant amount:\4030000 ( Direct expense: \3100000 、 Indirect expense:\930000 )

    Lung transplantation has become the treatment of end-stage lung disease. However, outcomes after lung transplantation remain worse than those after transplantation of other solid organs. Ischemia reperfusion injury is considered to be linked to the limitation to long term survival after lung transplantation. We examined the mechanism that ischemia reperfusion injury induces the abrogation of lung transplant acceptance.

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Class subject in charge

  • Surgery (2) (Core Clinical Practice) (2023academic year) special  - その他

  • Respiratory Medicine (2023academic year) special  - その他

  • General Surgery (2023academic year) special  - その他

  • Lecture : Elderly healthcare (2023academic year) special  - その他

  • Surgery (2) (Core Clinical Practice) (2022academic year) special  - その他

  • General Surgery (2022academic year) special  - その他

  • Lecture : Elderly healthcare (2022academic year) special  - その他

  • Surgery (2) (Core Clinical Practice) (2021academic year) special  - その他

  • General Surgery (2021academic year) special  - その他

  • Surgery (2) (Core Clinical Practice) (2020academic year) special  - その他

  • General Surgery (2020academic year) special  - その他

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Academic Activities

  • 岡山大学関連病院呼吸器外科フェス2024

    Role(s):Planning, management, etc., Panel moderator, session chair, etc.

    2024.3.9

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  • 日本呼吸器外科学会雑誌

    Role(s):Peer review

    2024.3

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  • 第28回岡山大学外科MCセミナー

    Role(s):Planning, management, etc., Panel moderator, session chair, etc.

    2024.2.10

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  • American Journal of Transplantation

    Role(s):Peer review

    2024.2

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  • Surgical Case Reports

    Role(s):Peer review

    2024.2

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  • 第40回日本肺および心肺移植研究会 一般演題(臨床研究1)

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    2024.1.27

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  • eBioMedicine

    Role(s):Peer review

    2023.12

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  • Surgery Today

    Role(s):Peer review

    2023.12

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  • 日本呼吸器外科学会雑誌

    Role(s):Peer review

    2023.10

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  • 第27回岡山大学外科MCセミナー サブスぺ専門医・技術認定医への道

    Role(s):Planning, management, etc., Panel moderator, session chair, etc.

    2023.9.2

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  • 日本呼吸器外科学会雑誌

    Role(s):Peer review

    2023.9

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  • Surgery Today

    Role(s):Peer review

    2023.8

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  • Acta Medica Okayama

    Role(s):Peer review

    2023.8

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  • 第40回日本呼吸器外科学会学術集会 ポスター83 稀な症例7

    Role(s):Panel moderator, session chair, etc.

    2023.7.13 - 2023.7.14

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  • Surgical Case Reports

    Role(s):Peer review

    2023.7

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  • 第66回関西胸部外科学会学術集会 Case Presentation Award 呼吸器(1)

    Role(s):Panel moderator, session chair, etc.

    2023.6.8 - 2023.6.9

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  • Surgery Today

    Role(s):Peer review

    2023.4

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  • American Journal of Transplantation

    Role(s):Peer review

    2023.4

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  • Research Festival 2023

    Role(s):Planning, management, etc., Panel moderator, session chair, etc.

    2023.3.25

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    Type:Academic society, research group, etc. 

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  • Journal of Thoracic Disease

    Role(s):Peer review

    2023.3

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    Type:Peer review 

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  • Transplantation

    Role(s):Peer review

    2023.3

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    Type:Peer review 

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  • 第39回日本肺および心肺移植研究会 一般演題 移植後の諸問題

    Role(s):Panel moderator, session chair, etc.

    2023.1.28

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    Type:Academic society, research group, etc. 

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  • Surgical Case Reports

    Role(s):Peer review

    2023.1

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    Type:Peer review 

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  • Transplant International

    Role(s):Peer review

    2022.11

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    Type:Peer review 

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  • 第60回日本肺癌学会 中国・四国支部学術集会 一般演題3 外科療法・胸腺・胸膜疾患

    Role(s):Panel moderator, session chair, etc.

    2022.7.9 - 2022.7.10

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    Type:Academic society, research group, etc. 

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  • Acta Medica Okayama

    Role(s):Peer review

    2022.5

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    Type:Peer review 

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  • Surgical Case Reports

    Role(s):Peer review

    2022.5

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    Type:Peer review 

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  • Research Festival 2022 基礎研究

    Role(s):Planning, management, etc., Panel moderator, session chair, etc.

    2022.3.19

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    Type:Academic society, research group, etc. 

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  • 第38回日本肺および心肺移植研究会 一般演題 症例・肺移植手術

    Role(s):Panel moderator, session chair, etc.

    2022.1.29

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    Type:Academic society, research group, etc. 

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  • General Thoracic and Cardiovascular Surgery

    Role(s):Peer review

    2021.12

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    Type:Peer review 

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  • American Journal of Transplantation

    Role(s):Peer review

    2021.11

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    Type:Peer review 

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  • 第74回日本胸部外科学会定期学術集会 JATS Case Presentation Awards 呼吸器2「気胸・感染症」

    Role(s):Panel moderator, session chair, etc.

    2021.10.31 - 2021.11.3

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    Type:Academic society, research group, etc. 

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  • 第57回日本移植学会総会 分野別ワークショップ3 肺移植における多職種連携

    Role(s):Panel moderator, session chair, etc.

    2021.9.18 - 2021.9.20

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    Type:Academic society, research group, etc. 

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  • General Thoracic and Cardiovascular Surgery

    Role(s):Peer review

    2021.9

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    Type:Peer review 

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  • 第63回日本呼吸器学会中国・四国地方会 一般演題 肺腫瘍・アスベスト関連疾患

    Role(s):Panel moderator, session chair, etc.

    2021.8.7 - 2021.8.8

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    Type:Academic society, research group, etc. 

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  • Surgery Today

    Role(s):Peer review

    2021.8

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    Type:Peer review 

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  • Acta Medica Okayama

    Role(s):Peer review

    2021.7

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    Type:Peer review 

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  • 第38回日本呼吸器外科学会学術集会 要望演題14 難治性膿胸に対する治療戦略2

    Role(s):Panel moderator, session chair, etc.

    2021.5.20 - 2021.5.21

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    Type:Academic society, research group, etc. 

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  • 第38回日本呼吸器外科学会学術集会 ミニオーラル97 肺癌-その他14

    Role(s):Panel moderator, session chair, etc.

    2021.5.20 - 2021.5.21

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    Type:Academic society, research group, etc. 

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  • Research Festival 2021 基礎研究

    Role(s):Planning, management, etc., Panel moderator, session chair, etc.

    2021.2.21

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  • 第37回日本肺および心肺移植研究会

    Role(s):Planning, management, etc.

    2021.1.30 - 2021.2.14

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  • 第37回日本肺および心肺移植研究会 要望演題①困難症例検討会

    Role(s):Panel moderator, session chair, etc.

    2021.1.30 - 2021.2.14

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    Type:Academic society, research group, etc. 

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  • Surgical Case Reports

    Role(s):Peer review

    2020.12

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  • 第61回日本肺癌学会学術集会

    Role(s):Planning, management, etc., Panel moderator, session chair, etc.

    2020.11.12 - 2020.11.14

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  • JTO Clinical and Research Reports

    Role(s):Peer review

    2020.9

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  • Transplantation

    Role(s):Peer review

    2020.7

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  • Journal of Thoracic Disease

    Role(s):Peer review

    2020.6

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  • Acta Medica Okayama

    Role(s):Peer review

    2020.5

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  • Transplantation

    Role(s):Peer review

    2020.3

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  • 第36回日本肺および心肺移植研究会

    Role(s):Panel moderator, session chair, etc.

    2020.1.25

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  • 第7回OUTSSG胸腔鏡セミナー

    Role(s):Panel moderator, session chair, etc.

    2020.1.10 - 2020.1.11

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  • Scientific Reports

    Role(s):Peer review

    2019.12

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  • The 15th Lung Transplantation Conference

    Role(s):Panel moderator, session chair, etc.

    2019.11.1

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  • International Journal of Chronic Obstructive Pulmonary Disease

    Role(s):Peer review

    2019.11

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  • 第55回日本移植学会総会

    Role(s):Panel moderator, session chair, etc.

    2019.10.10 - 2019.10.12

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  • European Journal of Pharmacology

    Role(s):Peer review

    2019.7

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  • 第35回日本肺および心肺移植研究会

    Role(s):Panel moderator, session chair, etc.

    2019.1.26

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  • Surgical Case Reports

    Role(s):Peer review

    2018.12

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  • Ann Transplant

    Role(s):Peer review

    2018.12

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  • Transplant international

    Role(s):Peer review

    2018.11

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  • Surgical Case Reports

    Role(s):Peer review

    2018.11

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  • Ann Transplant

    Role(s):Peer review

    2018.9

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  • Surgical Case Reports

    Role(s):Peer review

    2018.8

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  • Acta Medica Okayama

    Role(s):Peer review

    2018.7

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  • The 14th Lung Transplantation Conference

    Role(s):Panel moderator, session chair, etc.

    2018.5.18

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    Type:Academic society, research group, etc. 

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  • 第5回OUTSSG胸腔鏡セミナー

    Role(s):Panel moderator, session chair, etc.

    2018.2.23 - 2018.2.25

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  • Ann Transplant

    Role(s):Peer review

    2017.12

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  • Surgical Case Reports

    Role(s):Peer review

    2017.10

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  • 第90回岡山胸部疾患懇話会

    Role(s):Panel moderator, session chair, etc.

    2017.9.12

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  • 第5回岡山呼吸器外科カンファレンス

    Role(s):Panel moderator, session chair, etc.

    2017.8.26

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  • 第4回OUTSSG胸腔鏡セミナー

    Role(s):Panel moderator, session chair, etc.

    2017.1.20 - 2017.1.22

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  • Surgical Case Reports

    Role(s):Peer review

    2017.1

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  • 第69回日本胸部外科学会定期学術集会

    Role(s):Planning, management, etc.

    2016.9.28 - 2016.10.1

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  • Journal of Cardiothoracic Surgery

    Role(s):Peer review

    2016.9

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  • 第24回岡山呼吸器外科懇話会

    Role(s):Panel moderator, session chair, etc.

    2016.7.15

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  • Acta Medica Okayama

    Role(s):Peer review

    2016.7

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  • Transplantation Science Symposium Asian Regional Meeting 2016

    Role(s):Peer review

    2016.4

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  • 第52回日本移植学会総会

    Role(s):Planning, management, etc.

    2016

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  • 第30回日本肺および心肺移植研究会

    Role(s):Panel moderator, session chair, etc.

    2014.1.25

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  • 第175回岡山外科会

    Role(s):Planning, management, etc.

    2013.1.19

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  • 第51回日本肺癌学会中国・四国支部会

    Role(s):Panel moderator, session chair, etc.

    2012.7.21

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