Faculty Profiles - WASHIO Yousuke

Papers - WASHIO Yousuke

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Epidemiology of Pediatric Acute Encephalitis/Encephalopathy in Japan.

Shinichiro Goto, Nobuyuki Nosaka, Takashi Yorifuji, Tomoaki Wada, Yosuke Fujii, Masato Yashiro, Yosuke Washio, Kosei Hasegawa, Hirokazu Tsukahara, Tsuneo Morishima

Acta medica Okayama 72 ( 4 ) 351 - 357 2018.8

Language：English Publishing type：Research paper (scientific journal)

We studied the etiology of pediatric acute encephalitis/encephalopathy (pAEE) using epidemiological data obtained from a nationwide survey in Japan. Two-step questionnaires were sent to the pediatric departments of hospitals throughout the country in 2007, querying the number of the cases during 2005-2006 as the first step, and asking for the details of clinical information as the second step. In all, 636 children with pAEE (age ≤ 15 years) were enrolled. For the known etiology of pAEE (63.5% of the total cases), 26 microbes and 2 clinical entities were listed, but the etiology of 36.5% remained unknown. Influenza virus (26.7%), exanthem subitum (12.3%), and rotavirus (4.1%) were the most common, and the incidence of pAEE peaked at the age of 1 year. This trend was common among all etiologies. Among the neurological symptoms observed at the onset of pAEE, seizures were observed more often in patients aged ≤ 3 years, although abnormal speech and behavior were also common in older children. Undesirable outcomes (death and neurological sequelae) occurred at high rates in patients with any known etiology other than mycoplasma. In conclusion, these findings provide comprehensive insight into pAEE in Japan.

DOI： 10.18926/AMO/56170

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全前脳胞症に22q11.2欠失症候群を合併した1例

谷和祐, 牧尉太, 江口武志, 玉田祥子, 岡村朋香, 光井崇, 衛藤英理子, 早田桂, 鷲尾洋介, 吉本順子, 増山寿

日本周産期・新生児医学会雑誌 54 ( 2 ) 720 - 720 2018.6

Cover Image, Volume 176A, Number 3, March 2018. International journal

Kei Tamai, Katsuhiko Tada, Akihito Takeuchi, Makoto Nakamura, Hidenori Marunaka, Yosuke Washio, Hiroyuki Tanaka, Fuyuki Miya, Nobuhiko Okamoto, Misao Kageyama

American journal of medical genetics. Part A 176 ( 3 ) i 2018.3

Fetal ultrasonographic findings including cerebral hyperechogenicity in a patient with non-lethal form of Raine syndrome. International journal

Kei Tamai, Katsuhiko Tada, Akihito Takeuchi, Makoto Nakamura, Hidenori Marunaka, Yosuke Washio, Hiroyuki Tanaka, Fuyuki Miya, Nobuhiko Okamoto, Misao Kageyama

American journal of medical genetics. Part A 176 ( 3 ) 682 - 686 2018.3

Language：English Publishing type：Research paper (scientific journal)

Raine syndrome is a rare osteosclerotic bone dysplasia characterized by craniofacial anomalies and intracranial calcification. Most patients with Raine syndrome are of Arab ancestry and die during the neonatal period. We herein report a Japanese patient with non-lethal Raine syndrome who presented with characteristic cerebral hyperechogenicity and a hypoplastic nose by fetal ultrasonography. She was admitted to the NICU due to pyriform aperture stenosis. Craniofacial abnormalities, intracranial calcification, osteosclerosis, chondrodysplasia punctata, and a mutation of FAM20C was identified. She was subsequently discharged without surgical intervention and is now 2 years old with mild neurodevelopmental delays. Images of cerebral hyperechogenicity by fetal ultrasonography in a non-lethal case were described herein for the first time. This patient represents a rare occurrence of a child with Raine syndrome born to Japanese parents and confirms that this syndrome is not always lethal. Even if Raine syndrome is suspected in a fetus due to cerebral hyperechogenicity and a hypoplastic nose, cerebral hyperechogenicity without pulmonary hypoplasia does not always predict lethality or severe neurodevelopmental delays. The information provided herein will be useful for prenatal counseling.

DOI： 10.1002/ajmg.a.38598

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Emergency Caesarean Section Saved Both an Anti-MuSK Antibody-positive Myasthenia Gravis Mother with Pregnancy-induced Hypertension and Her Premature Baby.

Yoshiaki Takahashi, Toru Yamashita, Ryuta Morihara, Yumiko Nakano, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Kei Hayata, Hisashi Masuyama, Tomoka Okamura, Yosuke Washio, Koji Abe

Internal medicine (Tokyo, Japan) 56 ( 24 ) 3361 - 3364 2017.12

Language：English Publishing type：Research paper (scientific journal)

We herein report the case of a 46-year-old pregnant woman with anti-muscle specific kinase (MuSK) antibody-positive myasthenia gravis (MG) who showed pregnancy-induced hypertension and developed respiratory failure at 30 weeks and 5 days of pregnancy, and who underwent an emergency caesarean section (CS). Her MG symptoms gradually improved in the subsequent weeks. The premature baby with positive MuSK antibodies was successfully delivered, but the male baby required temporary artificial ventilation. However, his condition also gradually improved over time. The present case suggests that an emergency CS could rescue both the mother, who was in critical condition, and the prematurely born baby, even when suffering from acute respiratory insufficiency.

DOI： 10.2169/internalmedicine.8636-16

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羊水過多をきたし出生直後に気管切開を必要としたNager症候群の1例

江口武志, 谷和祐, 岡村朋香, 鷲尾洋介, 吉本順子, 増山寿, 平松祐司, 塚原宏一

日本周産期・新生児医学会雑誌 53 ( 2 ) 754 - 754 2017.6

当院で経験した気管無形成の3症例

谷和祐, 甲斐憲治, 清時毅典, 牧尉太, 岡本和浩, 江口武志, 玉田祥子, 岡村朋香, 光井崇, 衛藤英理子, 早田桂, 鷲尾洋介, 吉本順子, 増山寿, 平松祐司

日本周産期・新生児医学会雑誌 53 ( 2 ) 529 - 529 2017.6

Local and Systemic Immune Responses to Influenza A Virus Infection in Pneumonia and Encephalitis Mouse Models. International journal

Yoshiharu Nagaoka, Nobuyuki Nosaka, Mutsuko Yamada, Masato Yashiro, Yosuke Washio, Kenji Baba, Tsuneo Morishima, Hirokazu Tsukahara

Disease markers 2017 2594231 - 2594231 2017

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To compare local and systemic profiles between different disease pathologies (pneumonia and encephalitis) induced by influenza A virus (IAV). METHODS: An IAV pneumonia model was created by intranasal inoculation of C57BL/6 mice with influenza A/WSN/33 (H1N1) virus. Lung lavage and blood collection were performed on day 3 after IAV inoculation. Similarly, an IAV encephalitis mouse model was created by direct intracranial IAV inoculation. Cerebrospinal fluid (CSF) and blood collection were conducted according to the same schedule. Cytokine/chemokine profiles were produced for each collected sample. Then the data were compared visually using radar charts. RESULTS: Serum cytokine profiles were similar in pneumonia and encephalitis models, but local responses between the bronchoalveolar lavage fluid (BALF) in the pneumonia model and CSF in the encephalitis model differed. Moreover, to varying degrees, the profiles of local cytokines/chemokines differed from those of serum in both the pneumonia and encephalitis models. CONCLUSION: Investigating local samples such as BALF and CSF is important for evaluating local immune responses, providing insight into pathology at the primary loci of infection. Serum data alone might be insufficient to elucidate local immune responses and might not enable clinicians to devise the most appropriate treatment strategies.

DOI： 10.1155/2017/2594231

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【周産期医学必修知識第8版】新生児編未熟児くる病

塚原宏一, 鷲尾洋介, 吉本順子

周産期医学 46 ( 増刊 ) 896 - 899 2016.12

出生後早期に気道確保を必要とした上顎体、舌奇形腫、舌裂を合併した唇顎口蓋裂の一例

江口武志, 牧尉太, 谷和祐, 岡本和浩, 玉田祥子, 光井崇, 衛藤英理子, 早田桂, 増山寿, 鷲尾洋介, 吉本順子, 飯田征二, 平松祐司

現代産婦人科 65 ( Suppl. ) S46 - S46 2016.9

体重差が少ないMD双胎の管理と母体・新生児予後の検討

江口武志, 柏原麻子, 牧尉太, 玉田祥子, 光井崇, 平野友美加, 衛藤英理子, 早田桂, 増山寿, 平松祐司, 鷲尾洋介, 吉本順子

日本周産期・新生児医学会雑誌 52 ( 2 ) 750 - 750 2016.6

Hemodynamic analysis in infants with late-onset circulatory collapse. International journal

Yosuke Washio, Atsushi Uchiyama, Hidehiko Nakanishi, Satsuki Totsu, Kenichi Masumoto, Satoshi Kusuda

Pediatrics international : official journal of the Japan Pediatric Society 55 ( 5 ) 582 - 8 2013.10

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Late-onset circulatory collapse (LCC) is a disorder in which blood pressure decreases and oliguria suddenly occurs in preterm infants who have survived the acute stage, leading to shock, without contributing underlying factors. In order to evaluate hemodynamic changes during LCC, the correlation between myocardial functions and organ blood flow was investigated with echography. METHODS: Seven very-low-birthweight infants were given a diagnosis of LCC during the study period. Cardiovascular and organ flow parameters of the infants were recorded prospectively, once a week, and compared with eight control very-low-birthweight infants with matching gestational age. Echographic study was performed before LCC, at the onset of LCC, and after LCC among infants with LCC. RESULTS: A significant increase in ejection fraction and a significant decrease in end systolic wall stress were observed in infants with the LCC condition. At the same time, the mean blood flow velocity increased significantly in the superior mesenteric artery, while it decreased in the anterior cerebral artery. Systolic blood flow velocity increased and mean velocity was maintained in the renal artery during LCC. CONCLUSION: LCC is a distributive shock, characterized by a hyperdynamic state and decreased afterload. Echographic examination of organ flow during LCC is useful in understanding the pathophysiology of the disorder.

DOI： 10.1111/ped.12114

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Effect of Bifidobacterium administration on very-low-birthweight infants. International journal

Chika Yamasaki, Satsuki Totsu, Atushi Uchiyama, Hidehiko Nakanishi, Kenichi Masumoto, Yosuke Washio, Kyoko Shuri, Shuji Ishida, Ken Imai, Satoshi Kusuda

Pediatrics international : official journal of the Japan Pediatric Society 54 ( 5 ) 651 - 6 2012.10

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The aim of this study was to evaluate the efficacy and safety of early administration of Bifidobacterium bifidum OLB6378 (B. bifidum) on accelerating enteral feeding and bacterial colonization in very-low-birthweight (VLBW) infants. METHODS: We conducted a single-center prospective pilot study. Thirty-six VLBW infants were randomly divided into two groups: group E, wherein B. bifidum was supplemented within 48 h of birth, and group L, wherein it was supplemented more than 48 h after birth. RESULTS: Group E and group L reached a total feeding volume of 100 mL/(kg/day) after 10 [7-13] days and 11 [10-15] days, respectively (median [quartile]). The daily bodyweight gain in group E was significantly higher (21.4 ± 3.2 g/day vs 18.3 ± 4.0 g/day, P < 0.02; 11.1 ± 1.5 g/kg/day vs 10.4 ± 1.2 g/kg/day, P < 0.04). No significant differences were found in the fecal Bifidobacterium level between the groups quantitated with a real-time polymerase chain reaction assay at 1 and 4 weeks of age. However, the highest colonization rate of Bifidobacterium was observed when the supplementation started between 24 and 48 h after birth. The incidence of morbidities between the groups was similar. CONCLUSION: The early administration of B. bifidum to VLBW infants seems effective in promoting growth during the stay in the neonatal intensive care unit without increasing the incidence of morbidity. Furthermore, the preferable timing of starting the probiotic supplementation for VLBW infants is at latest less than 48 h after birth.

DOI： 10.1111/j.1442-200X.2012.03649.x

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Hydrocortisone and long-term outcomes in very-low-birthweight infants. International journal

Chika Yamasaki, Atsushi Uchiyama, Hidehiko Nakanishi, Kenichi Masumoto, Hiroyuki Aoyagi, Yosuke Washio, Satsuki Totsu, Ken Imai, Satoshi Kusuda

Pediatrics international : official journal of the Japan Pediatric Society 54 ( 4 ) 465 - 70 2012.8

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The long-term effects of hydrocortisone (HDC) used for very-low-birthweight (VLBW) infants with chronic lung disease (CLD) are not fully understood. The aim of this study was to examine the short-term clinical effects and long-term impact of a physiological replacement dose of HDC on acute deterioration of CLD in VLBW infants. METHODS: This prospective case-control study included 110 of the 174 VLBW infants admitted to our facility between 2003 and 2006 who were followed up to a corrected age of 18 months. Infant deaths and infants with congenital deformities were excluded from the study. The infants were classified into the following three groups: infants with CLD and treated with HDC (1-2 mg/kg/dose) due to progressive deterioration in oxygenation (CLD treatment group; n = 24); infants with CLD but not treated with HDC (CLD untreated group; n = 40); and infants without CLD (non-CLD group; n = 46). RESULTS: The fraction of inspired oxygen (F(I) O(2) ) in the CLD treatment group improved significantly after treatment (P < 0.01). There were no significant differences among the three groups in terms of growth and neurodevelopmental quotient at the corrected age of 18 months following adjustment for birthweight, sex, and presence of light-for-date infants. There were also no significant intergroup differences in all three areas of developmental quotient. CONCLUSIONS: Physiological doses of HDC replacement are effective in treating acute deterioration in oxygenation in VLBW infants with CLD. Furthermore, this treatment modality did not adversely affect the growth and development of infants at the corrected age of 18 months.

DOI： 10.1111/j.1442-200X.2012.03601.x

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