研究者詳細 - 前田　嘉信

MISC - 前田　嘉信

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Recombinant Thrombomodurin For The Treatment Of Transplantation-Associated Coagulopathy After Allogeneic Stem Cell Transplantation

Kazuyoshi Ishii, Shosaku Nomura, Tomoki Ito, Yuta Katayama, Taiichi Kyo, Shuichi Ota, Masanori Seki, Shigeru Chiba, Yoshinobu Maeda, Mitsune Tanimoto, Takayuki Ikezoe, Hideo Yagi, Yoji Ishida, Naohito Fujishima, Kenichi Sawada

BLOOD 122 ( 21 ) 2013年11月

Preparation of Enteric-coated Capsules of Beclomethasone Dipropionate for Patients with Intestinal Graft-versus-Host Disease and a Case Study

Kiminaka Murakawa, Tomoaki Sato, Yoshinobu Maeda, Yoshihisa Kitamura, Mitsune Tanimoto, Toshiaki Sendo

ACTA MEDICA OKAYAMA 67 ( 5 ) 319 - 324 2013年10月

記述言語：英語出版者・発行元：OKAYAMA UNIV MED SCHOOL

Graft-versus-host disease (GVHD) is a major concern in transplantation patients. Gut GVHD is accompanied by diarrhea, abdominal pain, and/or melena. Although oral treatment with corticosteroids (CSs) is effective in treating gut GVHD, it can cause adverse reactions that affect the entire body. Topical administration of CSs can be effective in treating diseases in which lesions are limited locally, because adverse reactions can then be alleviated. In this study, we examine and discuss an enteric-coated beclomethasone dipropionate (BDP) capsule (BDP-EC) formulated at Okayama University Hospital. The BDP-EC did not dissolve in solution 1 (pH1.2), and began disintegrating in solution 2 (pH6.8) after 5min, with a mean dissolution rate at 15min of 85%. We then used the capsule to treat a patient who developed gut GVHD after allogeneic hematopoietic stem cell transplantation. Clinically, the frequency of diarrhea decreased after BDP-EC administration. In addition, we were able to decrease the prednisolone equivalent dose. Symptoms associated with adverse reactions to BDP were not observed during the hospitalization period. These findings suggest that the administration of BDP-EC in the early stages of gut GVHD may allow a reduction in the initial doses of systemic CSs.

DOI： 10.18926/AMO/51868

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B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma without mediastinal disease: mimicking nodular sclerosis classical Hodgkin lymphoma

Noriko Iwaki, Yasuharu Sato, Toshiro Kurokawa, Yoshinobu Maeda, Kyotaro Ohno, Mai Takeuchi, Katsuyoshi Takata, Yorihisa Orita, Shinji Nakao, Tadashi Yoshino

MEDICAL MOLECULAR MORPHOLOGY 46 ( 3 ) 172 - 176 2013年9月

記述言語：英語出版者・発行元：SPRINGER JAPAN KK

B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma (BCLu-DLBCL/CHL), also known as gray-zone lymphoma, has overlapping clinical and biological characteristics of both diffuse large B-cell lymphoma and classical Hodgkin lymphoma (CHL). These lymphomas are typically associated with mediastinal disease, and extranodal involvement is rare. In the present report, we describe a case of a 78-year-old woman with BCLu-DLBCL/CHL found to have extranodal lesions and no evidence of mediastinal disease. Although biopsy specimens were histologically similar to nodular sclerosis CHL, the tumor cells were positive for CD30 and mature B-cell markers, such as CD20, CD79a, PAX5, BOB.1, and OCT-2, but negative for CD15. Furthermore, the patient had extranodal lesions and an increased level of soluble IL-2 receptor. These findings are unusual in CHL. Therefore, we diagnosed the patient with BCLu-DLBCL/CHL. She received adriamycin, bleomycin, vincristine, and dacarbazine therapy and exhibited partial response. Some cases without mediastinal disease, such as our case, have been reported; however, these cases are rare and further studies are required.

DOI： 10.1007/s00795-013-0038-8

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Distinct morphologic, phenotypic,and clinical-course characteristics of indolent peripheral T-cell lymphoma 国際誌

Hayashi E, Takata K, Sato Y, Tashiro Y, Tachiyama Y, Sawada-Kitamura S, Hiramatsu Y, Sugiguchi S, Nose S, Hirokawa M, Ando M, Alkader LA, Maeda Y, Tanimoto M, Yoshino T

Hum Pathol. 44 ( 9 ) 1927 - 1936 2013年9月

Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics (vol 26, pg 22, 2013)

Katsuyoshi Takata, Yasuharu Sato, Naoya Nakamura, Mami Tokunaka, Yukari Miki, Yara Yukie Kikuti, Kazuhiko Igarashi, Etsuro Ito, Hideo Harigae, Seiichi Kato, Eiko Hayashi, Takashi Oka, Yoshinobu Hoshii, Akira Tari, Hiroyuki Okada, Lamia Abd Al-Kader, Yoshinobu Maeda, Mitsune Tanimoto, Tomohiro Kinoshita, Tadashi Yoshino

MODERN PATHOLOGY 26 ( 8 ) 1152 - 1152 2013年8月

Comparison of outcomes between autologous and allogeneic hematopoietic stem cell transplantation for peripheral T-cell lymphomas with central review of pathology

S-W Kim, S-S Yoon, R. Suzuki, Y. Matsuno, H. G. Yi, T. Yoshida, M. Imamura, A. Wake, K. Miura, M. Hino, T. Ishikawa, J. S. Kim, Y. Maeda, J-J Lee, H. J. Kang, H. S. Lee, J-H Lee, K. Izutsu, T. Fukuda, C. W. Kim, T. Yoshino, K. Ohshima, S. Nakamura, K. Nagafuji, J. Suzumiya, M. Harada, C. S. Kim

LEUKEMIA 27 ( 6 ) 1394 - 1397 2013年6月

De novo CD5-positive diffuse large B-cell lymphomas show high specificity for cyclin D2 expression 国際誌

Takuro Igawa, Yasuharu Sato, Katsuyoshi Takata, Noriko Iwaki, Takehiro Tanaka, Naoko Asano, Yoshinobu Maeda, Yorihisa Orita, Naoya Nakamura, Shigeo Nakamura, Tadashi Yoshino

DIAGNOSTIC PATHOLOGY 8 81 - 81 2013年5月

記述言語：英語出版者・発行元：BIOMED CENTRAL LTD

D cyclins positively regulate the cell cycle and mediate the pathogenesis of some lymphomas. Cyclin D1 overexpression is the hallmark of mantle cell lymphoma, whereas cyclins D2 and D3 are reportedly not as specific to certain lymphomas as cyclin D1. In this study, cyclin D2 was found to be overexpressed in 98% of de novo CD5-positive diffuse large B-cell lymphomas (DLBCLs) (50/51) and in 28% of CD5-negative DLBCLs (14/51). A statistically significant difference was observed between these two groups (p<0.0001). In contrast, no statistical difference was found in the cyclin D3 expression between CD5-positive (18/51) and CD5-negative (24/51) DLBCLs (p=0.23). Based on these findings, cyclin D2 is therefore considered to be closely associated with de novo CD5-positive DLBCLs. This insight may be useful for overcoming the inferior survival of this aggressive lymphoma. Virtual slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1382856320966453

DOI： 10.1186/1746-1596-8-81

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Impact of a single human leucocyte antigen (HLA) allele mismatch on the outcome of unrelated bone marrow transplantation over two time periods. A retrospective analysis of 3003 patients from the HLAWorking Group of the Japan Society for Blood and Marro・・・国際誌

Kanda Y, Kanda J, Atsuta Y, Maeda Y, Ichinohe T, Ohashi K, Fukuda T, Miyamura K, Iida H, Mori T, Iwato K, Eto T, Kawa K, Morita S, Morishima Y

Br J Haematol. 161 ( 4 ) 566 - 577 2013年5月

MTX中止直後に一過性の白血球増多を認め、その後自然退縮したMTX-LPDの一例

近藤英生, 葛島清隆, 市村浩一, 前田嘉信, 藤井伸治, 松岡賢市, 品川克至, 長谷川詠子, 黒井大雅, 佐伯恭昌, 浅野豪, 高田尚良, 佐藤康晴, 吉野正, 谷本光音

日本リンパ網内系学会会誌 53 133 - 133 2013年4月

ハプロフル移植を施行した全身性Bacillus cereus多発膿瘍を合併した急性骨髄単球性白血病の一例

長谷川詠子, 佐伯恭昌, 黒井大雅, 淺野豪, 松岡賢市, 近藤英生, 淺田騰, 藤井敬子, 藤井伸治, 前田嘉信, 品川克至, 谷本光音

日本造血細胞移植学会総会プログラム・抄録集 35th 275 2013年2月

Antibiotic sensitivity of bacteria on the oral mucosa after hematopoietic cell transplantation 国際誌

Yoshihiko Soga, Yoshinobu Maeda, Mitsune Tanimoto, Takayuki Ebinuma, Hiroshi Maeda, Shogo Takashiba

SUPPORTIVE CARE IN CANCER 21 ( 2 ) 367 - 368 2013年2月

Mediastinal gray zone lymphomaに対しRituximab併用DA-EPOCH療法を施行した3症例

吉岡尚徳, 佐伯恭昌, 浅野豪, 松岡賢市, 藤井伸治, 近藤英生, 前田嘉信, 品川克至, 吉野正, 谷本光音

日本内科学会雑誌 102 ( Suppl. ) 187 - 187 2013年2月

Contribution of the PD-1-PD-L Pathway to Chronic Graft-Versus-Host Disease

Hideaki Fujiwara, Koichiro Kobayashi, Hisakazu Nishimori, Masaaki Nishinohara, Sachiyo Okamoto, Ken-ichi Matsuoka, Eisei Kondo, Nobuharu Fujii, Katsuji Shinagawa, Mitsune Tanimoto, Yoshinobu Maeda

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 19 ( 2 ) S324 - S325 2013年2月

Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics 国際誌

Katsuyoshi Takata, Yasuharu Sato, Naoya Nakamura, Mami Tokunaka, Yukari Miki, Yara Yukie Kikuti, Kazuhiko Igarashi, Etsuro Ito, Hideo Harigae, Seiichi Kato, Eiko Hayashi, Takashi Oka, Yoshinobu Hoshii, Akira Tari, Hiroyuki Okada, Abd Alkader Lamia Mohamad, Yoshinobu Maeda, Mitsune Tanimoto, Tomohiro Kinoshita, Tadashi Yoshino

Modern Pathology 26 ( 1 ) 22 - 31 2013年1月

記述言語：英語

We have reported previously that duodenal follicular lymphoma (FL) is distinct from nodal FL and showed more resemblance to mucosa-associated lymphoid tissue lymphoma, and that FL frequently involved the duodenal second portion. In the present study, we examined duodenal FLs and gastric/colonic FLs to clarify the clinicopathological and immunological differences between the tumor types. We analyzed 8 samples of gastric FL, 17 of duodenal ones, and 5 of colonic/rectal ones, and characterized them by immunohistochemistry, immunogenotyping, and histology. Gastric and colonic FLs presented in submucosal to subserosal areas, whereas duodenal ones presented in the mucosal to submucosal layers. Immunohistochemical analysis revealed that duodenal FLs exhibited the following phenotypes: CD10 (+), B-cell lymphoma 2 (BCL-2) (+), BCL-6 (+), activation-induced cytidine deaminase (AID) (-), BACH2 (+), CD27 (+), MUM-1 (-), Blimp-1 (-), and loose CD21 network (duodenal pattern). Gastric/colonic FLs exhibited the following phenotypes: CD10 (+), BCL-2 (+), BCL-6 (+), AID (+), BACH2 (+), CD27 (-), MUM-1 (-), Blimp-1 (-), and a dense CD21 network (nodal pattern). Expression of AID and CD27 in lymphoma cells and the CD21 network pattern were considerably different between duodenal FLs and gastric/colonic ones. Moreover, in situ hybridization revealed that, in the duodenal FLs, BACH2 was expressed at the periphery of the tumor follicle and tumor villi. The number of immunoglobulin heavy-chain variable domains VH4 and VH5 were higher in duodenal follicular lymphomoas than in gastric FLs. The lymphoma cells of duodenal FLs are different from those of gastric/colonic FLs, and duodenal FL is distinct even within the gastrointestinal tract. Somatic hypermutation in immunoglobulin genes and CD27 expression are hallmarks of memory B cells. We suggest that duodenal FL cells are in the memory B-cell stage, and require BACH2 instead of AID for ongoing mutation. © 2013 USCAP, Inc.

DOI： 10.1038/modpathol.2012.127

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Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics

Katsuyoshi Takata, Yasuharu Sato, Naoya Nakamura, Mami Tokunaka, Yukari Miki, Yara Yukie Kikuti, Kazuhiko Igarashi, Etsuro Ito, Hideo Harigae, Seiichi Kato, Eiko Hayashi, Takashi Oka, Yoshinobu Hoshii, Akira Tari, Hiroyuki Okada, Abd Alkader Lamia Mohamad, Yoshinobu Maeda, Mitsune Tanimoto, Tomohiro Kinoshita, Tadashi Yoshino

Modern Pathology 26 ( 1 ) 22 - 31 2013年1月

記述言語：英語

DOI： 10.1038/modpathol.2012.127

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当院同種造血幹細胞移植症例におけるDisease risk indexの有用性の検討

浅野豪, 近藤英生, 佐伯恭昌, 長谷川詠子, 黒井大雅, 西森久和, 松岡賢市, 浅田騰, 藤井敬子, 藤井伸治, 藤井伸治, 前田嘉信, 品川克至, 谷本光音

日本造血細胞移植学会総会プログラム・抄録集 35th 2013年

非血縁者間骨髄移植後再発に対してドナーリンパ球輸注療法が著効したGATA2変異を有するMonoMac症候群の1例

増成太郎, 枝廣暁, 大倉浩子, 鈴木優子, 長澤紗詠子, 木村耕介, 木口亨, 瀬崎伸夫, 石井啓太, 吉岡尚徳, 西森久和, 新谷大悟, 藤井伸治, 前田嘉信, 品川克至, 村松秀城, 小島勢二, 新谷憲治

日本造血細胞移植学会総会プログラム・抄録集 35th 2013年

慢性graft versus host disease(GVHD)に関連した腎障害の3例

井上章子, 北川正史, 大西章文, 菊本陽子, 喜多村真治, 前島洋平, 杉山斉, 槇野博史, 前田嘉信

日本腎臓学会誌 55 ( 6 ) 2013年

Detection of T-cell receptor γ gene rearrangement in paraffin-embedded T or NK/T cell lymphoma samples using the BIOMED-2 protocol. 国際誌

Miyata-Takata T, Takata K, Yamanouchi S, Sato Y, Harada M, Oka T, Tanaka T, Maeda Y, Tanimoto M, Yoshino T

Leuk Lymphoma 55 ( 9 ) 2161 - 4 2013年

Mediastinal gray zone lymphomaに対しRituximab併用DA-EPOCH療法を施行した3症例

佐伯恭昌, 吉岡尚徳, 淺野豪, 黒井大雅, 長谷川詠子, 松岡賢市, 藤井伸治, 近藤英生, 前田嘉信, 品川克至, 吉野正, 谷本光音

日本癌治療学会誌 47 ( 3 ) 2508 - 2508 2012年10月

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