Faculty Profiles - UCHIDA Haruhito

Papers - UCHIDA Haruhito

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Vasohibin-2は大動脈瘤モデルマウスにおいて胸部大動脈瘤を増悪させる

奥山倫弘, 内田治仁, 梅林亮子, 垣尾勇樹, 田邊克幸, 藤井泰宏, 大澤晋, 佐藤靖史, 佐野俊二, 和田淳

脈管学 56 ( Suppl. ) S153 - S153 2016.10

The possible involvement of intestine-derived IgA1: a case of IgA nephropathy associated with Crohn's disease. Reviewed International journal

Tomohiro Terasaka, Haruhito A Uchida, Ryoko Umebayashi, Keiko Tsukamoto, Keiko Tanaka, Masashi Kitagawa, Hitoshi Sugiyama, Hiroaki Tanioka, Jun Wada

BMC nephrology 17 ( 1 ) 122 - 122 2016.9

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: A link between IgA nephropathy and Crohn's disease has recently been reported. Other researchers hypothesize that intestine-derived IgA complexes deposit in glomerular mesangial cells, eliciting IgA nephropathy. Intestinal mucosal plasma cells mainly secrete IgA2. Nevertheless, IgA1 deposition is strongly implicated as being the primary cause of IgA nephropathy. CASE PRESENTATION: A 46-year-old Japanese man developed IgA nephropathy 29 years ago, following tonsillectomy. As a result, a normal urinalysis was obtained. The patient previously suffered Crohn's disease followed by urinary occult blood and proteinuria six years ago. Exacerbation of IgA nephropathy was highly suspected. Therefore a renal biopsy was performed. A diagnosis of exacerbation of IgA nephropathy with mesangial cell proliferation and fibrotic cellular crescent was based upon the pathological findings. The patient exhibited a positive clinical course and eventually achieved a remission with immunosuppressive therapy including prednisolone treatment. Immunostaining for the detection of IgA subtypes was performed on both of his kidney and excised ileum. The results revealed IgA1 and IgA2 deposition by submucosal cells in intestine. Furthermore, IgA1 deposition of mesangial areas in the patient's kidney, indicated an association of IgA1 with the exacerbation of IgA nephropathy. CONCLUSION: This case represents the possibility that the intestine-derived IgA1 can be the origin of galactose-deficient IgA which is known to cause IgA nephropathy exacerbation.

DOI： 10.1186/s12882-016-0344-1

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The Possible Association of the Incidence of ESRD in the Patient with Diabetic Nephropathy with Salt Intake in the World Reviewed

Haruhito A. Uchida, Jun Wada, Hirofumi Makino

BMJ open e-letter 2016.8

Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice. Reviewed International journal

Deborah A Howatt, Anju Balakrishnan, Jessica J Moorleghen, Latha Muniappan, Debra L Rateri, Haruhito A Uchida, Jiro Takano, Takaomi C Saido, Athar H Chishti, Laurent Baud, Venkateswaran Subramanian

Arteriosclerosis, thrombosis, and vascular biology 36 ( 5 ) 835 - 45 2016.5

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Angiotensin II (AngII) infusion profoundly increases activity of calpains, calcium-dependent neutral cysteine proteases, in mice. Pharmacological inhibition of calpains attenuates AngII-induced aortic medial macrophage accumulation, atherosclerosis, and abdominal aortic aneurysm in mice. However, the precise functional contribution of leukocyte-derived calpains in AngII-induced vascular pathologies has not been determined. The purpose of this study was to determine whether calpains expressed in bone marrow (BM)-derived cells contribute to AngII-induced atherosclerosis and aortic aneurysms in hypercholesterolemic mice. APPROACH AND RESULTS: To study whether leukocyte calpains contributed to AngII-induced aortic pathologies, irradiated male low-density lipoprotein receptor(-/-) mice were repopulated with BM-derived cells that were either wild-type or overexpressed calpastatin, the endogenous inhibitor of calpains. Mice were fed a fat-enriched diet and infused with AngII (1000 ng/kg per minute) for 4 weeks. Overexpression of calpastatin in BM-derived cells significantly attenuated AngII-induced atherosclerotic lesion formation in aortic arches, but had no effect on aneurysm formation. Using either BM-derived cells from calpain-1-deficient mice or mice with leukocyte-specific calpain-2 deficiency generated using cre-loxP recombination technology, further studies demonstrated that independent deficiency of either calpain-1 or -2 in leukocytes modestly attenuated AngII-induced atherosclerosis. Calpastatin overexpression significantly attenuated AngII-induced inflammatory responses in macrophages and spleen. Furthermore, calpain inhibition suppressed migration and adhesion of macrophages to endothelial cells in vitro. Calpain inhibition also significantly decreased hypercholesterolemia-induced atherosclerosis in the absence of AngII. CONCLUSIONS: The present study demonstrates a pivotal role for BM-derived calpains in mediating AngII-induced atherosclerosis by influencing macrophage function.

DOI： 10.1161/ATVBAHA.116.307285

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腎機能障害を合併した治療抵抗性高血圧症の一例

遠藤豊宏, 内田治仁, 谷村智史, 三瀬広記, 井上達之, 竹内英実, 垣尾勇樹, 梅林亮子, 杉山斉, 和田淳

日本高血圧学会臨床高血圧フォーラムプログラム・抄録集 5回 181 - 181 2016.5

Acute idiopathic blue fingers: a young man with Achenbach's syndrome. Reviewed International journal

Hidemi Takeuchi, Haruhito Adam Uchida, Yuka Okuyama, Jun Wada

BMJ case reports 2016 10.1136/bcr-2016-214491 2016.4

Language：English Publishing type：Research paper (scientific journal)

We report a case of a 20-year-old man presenting with acute painful blue fingers. All physical findings, including an Allen test, were normal, and systematic symptoms frequently seen in collagen diseases were absent. Although we performed a wide variety of investigations including medical imaging, no specific abnormal findings were observed. Skin biopsy pathology was an important reference. The patient's symptoms gradually improved and were completely resolved without specific treatment. Based on the clinical presentation and course, we gave a diagnosis of Achenbach's syndrome, developed in a young male. Achenbach's syndrome is rare, but still may be encountered in clinical practice. The symptoms can be startling to the patient, eliciting fear of something terrible when, in fact, the syndrome is relatively benign and has a good prognosis. Recognising this disease quickly after presentation helps to eliminate the anxiety of the patient, as well as reducing excessively invasive investigations. We present a case report to enlighten Achenbach's syndrome.

DOI： 10.1136/bcr-2016-214491

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Chronic Kidney Disease Is Positively and Diabetes Mellitus Is Negatively Associated with Abdominal Aortic Aneurysm. Reviewed International journal

Hidemi Takeuchi, Michihiro Okuyama, Haruhito A Uchida, Yuki Kakio, Ryoko Umebayashi, Yuka Okuyama, Yasuhiro Fujii, Susumu Ozawa, Masashi Yoshida, Yu Oshima, Shunji Sano, Jun Wada

PloS one 11 ( 10 ) e0164015 2016

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND AND AIMS: Chronic kidney disease (CKD) and diabetes mellitus (DM) are considered as risk factors for cardiovascular diseases. The purpose of this study was to clarify the relationship of CKD and DM with the presence of abdominal aortic aneurysm (AAA). METHODS: We enrolled 261 patients with AAA (AAA+) and age-and-sex matched 261 patients without AAA (AAA-) at two hospitals between 2008 and 2014, and examined the association between the risk factors and the presence of AAA. Furthermore, in order to investigate the prevalence of AAA in each group, we enrolled 1126 patients with CKD and 400 patients with DM. RESULTS: The presence of CKD in patients with AAA+ was significantly higher than that in patients with AAA- (AAA+; 65%, AAA-; 52%, P = 0.004). The presence of DM in patients with AAA+ was significantly lower than that in patients with AAA- (AAA+; 17%, AAA-; 35%, P < 0.001). A multivariate logistic regression analysis demonstrated that hypertension, ischemic heart disease and CKD were independent determinants, whereas, DM was a negatively independent determinant, for the presence of AAA. The prevalence of AAA in patients with CKD 65 years old and above was 5.1%, whereas, that in patients with DM 65 years old and above was only 0.6%. CONCLUSION: CKD is a positively associated with the presence of AAA. In contrast, DM is a negatively associated with the presence of AAA in Japanese population.

DOI： 10.1371/journal.pone.0164015

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Successful treatment by mycophenolate mofetil in a patient with focal segmental glomerulosclerosis associated with posterior reversible encephalopathy syndrome. Reviewed

Masafumi Tenta, Haruhito Adam Uchida, Tomokazu Nunoue, Ryoko Umebayashi, Yuka Okuyama, Masashi Kitagawa, Yohei Maeshima, Hitoshi Sugiyama, Jun Wada

CEN case reports 4 ( 2 ) 190 - 195 2015.11

Language：English Publishing type：Research paper (scientific journal)

It has been reported that cyclosporine A (CsA) treatment may be associated with posterior reversible encephalopathy syndrome. We report a 16-year-old man who exhibited nephrotic syndrome and posterior reversible encephalopathy syndrome. Intensive antihypertensive therapy restored him to consciousness. Renal biopsy revealed that he suffered from focal segmental glomerulosclerosis. Although he was treated with prednisolone and low-density lipoprotein apheresis therapy, his proteinuria remained at high level. Then, mycophenolate mofetil (MMF) with less influence on vessel endothelium compared with CsA and tacrolimus was administered. Soon after, he reached remission of nephrotic syndrome without recurrence of posterior reversible encephalopathy syndrome. This is the first case that a young patient of focal segmental glomerulosclerosis with posterior reversible encephalopathy syndrome achieved a complete remission by MMF treatment without recurrence of posterior reversible encephalopathy syndrome. MMF may be effective for young patients of focal segmental glomerulosclerosis especially with clinical condition of vascular endothelial damage such as posterior reversible encephalopathy syndrome.

DOI： 10.1007/s13730-014-0165-7

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有痛性手指チアノーゼを来した若年男性の1例

竹内英実, 内田治仁, 奥山由加, 垣尾勇樹, 梅林亮子, 武本梨佳, 戸田洋伸, 藤井泰宏, 大澤晋, 村上和敏, 大塚文男, 和田淳

脈管学 55 ( Suppl. ) S246 - S247 2015.10

下大静脈フィルター閉塞が誘因となった症候性下肢動静脈瘻の2症例 Reviewed

大澤晋, 藤井泰宏, 藤原寛康, 増田善逸, 黒子洋介, 戸田洋伸, 内田治仁, 村上和敏, 江尻健太郎, 高樽由美, 料治三恵, 逢坂大樹, 竹内英実, 武本梨佳, 本田雅子, 三宅麻希, 佐野俊二

脈管学 55 ( Suppl. ) S212 - S212 2015.10

日本人の体格を考慮した、タバコ窩内シャント設置術適応の検討

藤井泰宏, 大澤晋, 黒子洋介, 増田善逸, 佐野俊二, 内田治仁, 竹内英実, 戸田洋伸, 逢坂大樹, 武本梨佳

脈管学 55 ( Suppl. ) S179 - S179 2015.10

Retrograde Renal Ablation via the Renal Vein as a New Treatment Option for Renovascular Hypertension. Reviewed International journal

Hiroyasu Fujiwara, Hideo Gobara, Takao Hiraki, Toshihiro Iguchi, Haruhito Adam Uchida, Susumu Kanazawa

Journal of vascular and interventional radiology : JVIR 26 ( 6 ) 807 - 8 2015.6

血中FGF21は腎機能、蛋白尿と独立した腎予後を予測するバイオマーカーである

北川正史, 杉山斉, 森永裕士, 秋山愛由, 山成俊夫, 大西章史, 田中景子, 菊本陽子, 井上達之, 内田治仁, 和田淳

日本腎臓学会誌 57 ( 3 ) 465 - 465 2015.4

Autoimmune pancreatitis and minimal change nephrotic syndrome: an unusual association? Reviewed International journal

Yuka Okuyama, Haruhito Adam Uchida, Masafumi Tenta, Tomokazu Nunoue, Ryoko Umebayashi, Hiroshi Morinaga, Shinji Kitamura, Yohei Maeshima, Hitoshi Sugiyama, Jun Wada

Nephrology (Carlton, Vic.) 20 ( 3 ) 225 - 6 2015.3

Effects of lanthanum carbonate versus calcium carbonate on vascular stiffness and bone mineral metabolism in hemodialysis patients with type 2 diabetes mellitus: a randomized controlled trial. Reviewed International journal

Kentaro Wada, Yuko Wada, Haruhito Adam Uchida, Shuichi Tsuruoka

International journal of nephrology and renovascular disease 8 111 - 8 2015

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Vascular calcification contributes to cardiovascular disease in hemodialysis (HD) patients with diabetes. The randomized controlled trial reported here compared the effects of lanthanum carbonate (LC) and calcium carbonate (CC) on vascular stiffness assessed using brachial-ankle pulse wave velocity (ba-PWV), intima-media thickness (IMT), bone mineral density (BMD), and serum markers of chronic kidney disease - mineral and bone disorder in such patients. METHODS: Ba-PWV, IMT, BMD, and the biomarkers osteocalcin (OC) and bone alkaline phosphatase (BAP) were examined in 43 type 2 diabetes HD patients treated with LC (n=21) or CC (n=22) for 2 years. RESULTS: Forty-one patients completed the study (19, LC; 22, CC). The mean ba-PWV significantly increased only in the CC group (median: 2,280.5 to 2,402.5 cm/s, P<0.05), after 24-month treatment; it remained unchanged in the LC group (median: 1,830.5 to 2,018.3 cm/s). However, the difference between the groups did not reach statistical significance. Changes in IMT and BMD were not different between the two groups. Changes in serum phosphorus, corrected calcium, and intact parathyroid hormone levels were similar between the groups. The incidence of fracture was 0% (0/19) in the LC group, and 13.6% (3/22) in the CC group (P=0.2478). The OC/BAP ratio increased significantly in the LC group (median: 0.83 to 2.47), compared with in the CC group (median: 0.77 to 1.40) (P=0.036). CONCLUSION: From this study, in Japanese type 2 diabetes HD patients, we conclude that 2-year treatment with LC might have slowed the progression of ba-PWV; however, it did not cause a difference in ba-PWV, IMT, BMD, or fracture, compared with CC. Further, LC increased the OC/BAP ratio to a greater extent than CC.

DOI： 10.2147/IJNRD.S90791

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当科で施行した生体腎移植レシピエント、ドナーのQOL評価

有吉勇一, 荒木元朗, 宗石理沙, 吉岡貴史, 和田耕一郎, 小林泰之, 佐々木克己, 江原伸, 渡辺豊彦, 那須保友, 公文裕巳, 有森千聖, 北川正史, 田邊克幸, 森永裕士, 菊本陽子, 内田治仁, 喜多村真治, 前島洋平, 杉山斉, 槇野博史

移植 49 ( 4-5 ) 377 - 377 2014.11

Acute Effect of Aliskiren on Smoking-Induced Endothelial Dysfunction in Smoker Reviewed

Haruhito A. Uchida, Hatsuzo Uchida, Jun Wada

Journal of Cardiovascular Medicine and Cardiology 038 - 041 2014.10

潰瘍性大腸炎に合併した腎血管性高血圧の1例

田中景子, 内田治仁, 平松澄恵, 天田雅文, 井上章子, 奥山由加, 梅林亮子, 郷原英夫, 大澤晋, 平岡佐規子, 寺坂律子, 杉山斉, 和田淳

脈管学 54 ( 10 ) 167 - 172 2014.10

Language：Japanese Publisher：(一社)日本脈管学会

腎血管性高血圧はさまざまな疾患を原因とする。今回我々は、潰瘍性大腸炎に腎血管性高血圧を合併した症例を経験した。症例は40歳男性。造影CTと血管造影で右腎動脈の閉塞と側副血行路の発達を認めた。さらに左腎区域動脈と肝動脈の狭小化、両側内腸骨動脈の閉塞と腹部大動脈の一部壁不整がみられた。FDG-PETで大動脈炎症候群は否定的であった。皮疹や結腸粘膜の生検で血管炎の所見は得られず、診断に苦慮した症例であった。(著者抄録)

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2014&ichushi_jid=J01422&link_issn=&doc_id=20141212320002&doc_link_id=10.7133%2Fjca.14-00031&url=https%3A%2F%2Fdoi.org%2F10.7133%2Fjca.14-00031&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

インターフェロン(IFN)が著効した生体肝移植後HCV陽性の膜性増殖性糸球体腎炎(MPGN)の1例

田中景子, 内田治仁, 井上章子, 雛元紀和, 北川正史, 高木章乃夫, 杉山斉, 和田淳

日本腎臓学会誌 56 ( 6 ) 702 - 702 2014.8

Large vessel vasculitis with myelodysplastic syndrome. Reviewed

Takayuki Katsuyama, Haruhito Adam Uchida, Kishio Toma, Yoshinobu Maeda, Daisho Hirota, Ryoko Umebayashi, Ken-Ei Sada, Hirofumi Makino

Internal medicine (Tokyo, Japan) 53 ( 1 ) 63 - 6 2014

Language：English Publishing type：Research paper (scientific journal)

A 71-year-old woman presented with a high-grade fever, neck pain, anemia and thrombocytopenia. After performing further examinations, we concluded that she had simultaneously developed large vessel vasculitis and myelodysplastic syndrome (MDS). Although glucocorticoid administration improved her clinical symptoms, the MDS transformed into acute myeloid leukemia and she died one year after receiving the diagnosis. The occurrence of immune-mediated disorders in patients with MDS is a well-known phenomenon; however, large vessel vasculitis is a rare complication of MDS. Our case suggests that the association between systemic vasculitis and MDS may result in poor outcomes.

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