Updated on 2024/02/08

写真a

 
UCHIDA Haruhito
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Special-Appointment Professor
Position
Special-Appointment Professor
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Degree

  • Doctor (MD, PhD) ( 2006.3   Okayama University )

Research Areas

  • Life Science / General internal medicine

Education

  • Okayama University   医学部大学院医学研究科  

    1999.4 - 2006.3

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    Country: Japan

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  • Okayama University   医学部   医学科

    1993.4 - 1999.3

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    Country: Japan

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Professional Memberships

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Papers

  • Organ Damage and Quality of Life in Takayasu Arteritis - Evidence From a National Registry Analysis.

    Hajime Yoshifuji, Yoshikazu Nakaoka, Haruhito A Uchida, Takahiko Sugihara, Yoshiko Watanabe, Sohei Funakoshi, Mitsuaki Isobe, Masayoshi Harigai

    Circulation journal : official journal of the Japanese Circulation Society   2023.12

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    BACKGROUND: Takayasu arteritis, affecting primarily young women, damages large arteries and organs. We examined the impact of disease duration and sex on organ damage and quality of life using Japan's Intractable Disease Registry.Methods and Results: After refining data, 2,013 of 2,795 patients were included in the study. Longer disease duration was related to a lower prevalence of disease activity symptoms, a higher prevalence of organ damage, and a higher proportion of patients requiring nursing care. Compared with men, women tended to have an earlier onset age, exhibiting longer disease duration. A higher proportion of women had aortic regurgitation and required nursing care. The proportion of female patients in employment was lower than that of the general female population, whereas no difference was observed between male patients and the general male population. Logistic regression analysis revealed that age at surveillance, brain ischemia, visual impairment/loss, and ischemic heart disease were significant factors associated with high nursing care needs (Level ≥2, with daily activity limitations). CONCLUSIONS: Early diagnosis and effective treatment, particularly to prevent brain ischemia, visual impairment, and ischemic heart disease, may improve the quality of life of patients with Takayasu arteritis, especially women.

    DOI: 10.1253/circj.CJ-23-0656

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  • Kidney Veno-Muscular Characteristics and Kidney Disease Progression: A Native Kidney-Biopsy Study. International journal

    Kenji Tsuji, Hiroyuki Nakanoh, Kensaku Takahashi, Takafumi Morita, Yizhen Sang, Kazuhiko Fukushima, Natsumi Matsuoka-Uchiyama, Yasuhiro Onishi, Haruhito A Uchida, Shinji Kitamura, Jun Wada

    Kidney medicine   5 ( 12 )   100733 - 100733   2023.12

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    RATIONALE & OBJECTIVE: Assessment of kidney biopsies provides crucial information for diagnosis and disease activity, as well as prognostic value. Kidney-biopsy specimens occasionally contain veno-muscular complex (VMC), which consists of muscle tissues around the kidney venous system in the corticomedullary region. However, the role of VMC and the clinical significance of VMC variants are poorly understood. In the present study, we investigated kidney prognostic values of VMC variants. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: Among 808 patients who underwent a kidney biopsy from 2011 to 2019, 246 patients whose kidney biopsy specimens contained VMC were enrolled. PREDICTORS: VMC variants; inflammatory-VMC (an infiltration of ≥80 inflammatory cells/mm2-VMC area) and VMC hypertrophy (hyper-VMC, a VMC average width ≥850 μm), and the interstitial fibrosis/tubular atrophy (IFTA) score. OUTCOMES: A decline in estimated glomerular filtration rate (eGFR) ≥40% from the baseline or commencement of kidney replacement therapy. ANALYTICAL APPROACH: Cox proportional hazards model. RESULTS: Among 246 patients with data on VMC, mean baseline eGFR was 56.0±25.6 ml/min per 1.73 m2; 80 had high inflammatory-VMC, and 62 had VMC hypertrophy. There were 51 kidney events over median follow-up of 2.5 years. We analyzed 2 VMC variants. Multivariable logistic regression analysis revealed that eGFR negatively correlated with the presence of both inflammatory-VMC and hyper-VMC. A Cox proportional hazards analysis revealed that inflammatory-VMC (but not hyper-VMC) was independently associated with the primary outcome after adjustments for known risk factors of progression, including proteinuria, eGFR, and the interstitial fibrosis/tubular atrophy (IFTA) score (hazard ratio, 1.97; 95% confidence interval, 1.00-3.91). LIMITATIONS: Single-center study and small sample size. CONCLUSIONS: Assessment of inflammatory-VMC provides additional kidney prognostic information to known indicators of kidney disease progression in patients who undergo kidney biopsy. PLAIN-LANGUAGE SUMMARY: Assessment of kidney biopsies provides crucial information for diagnosis, disease activity, and prognostic value. Kidney-biopsy specimens occasionally contain veno-muscular complex (VMC), which consists of muscle tissues around the kidney venous system. Currently, the role of VMC in kidney health and diseases and the clinical significance of VMC variants are poorly understood. In the present study, we have shown that an infiltration of ≥80 inflammatory cells/mm2-VMC area (inflammatory-VMC) is independently associated with kidney disease progression after adjustments for known risk factors of progression. Therefore, assessment of inflammatory-VMC provides additional kidney prognostic information to known indicators of kidney disease progression in patients who undergo kidney biopsy.

    DOI: 10.1016/j.xkme.2023.100733

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  • Neutrophil Elastase Inhibition by Sivelestat (ONO-5046) Attenuates AngII-induced Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Mice. International journal

    Yoshiko Hada, Haruhito A Uchida, Shugo Okamoto, Nozomu Otaka, Katsuyoshi Katayama, Venkateswaran Subramanian, Alan Daugherty, Jun Wada

    American journal of hypertension   2023.11

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    BACKGROUND: Abdominal aortic aneurysm (AAA) is an arterial disease characterized by dilatation of the aortic wall. It has been suggested that neutrophil counts and neutrophil elastase activity are associated with AAA. We investigated whether a neutrophil elastase (NE) inhibitor, sivelestat (Siv), had a protective effect against angiotensin II (AngII)-induced AAAs. METHODS: Male apolipoprotein E-deficient mice were assigned into 3 groups: Vehicle+saline, AngII+saline, and AngII+Siv. All mice were administered intraperitoneally with either Siv or vehicle twice daily after AngII infusion. RESULTS: In the 4-week AngII infusion study, plasma NE concentration (p=0.041) and its activity (p=0.011) were elevated by AngII. These increases were attenuated by Siv (concentration:p=0.010, activity:p=0.027). Further, plasma elastase activity was closely correlated with aortic width (R=0.6976, p<0.001). In the 1-week AngII infusion study, plasma and tissue elastase activity increased by AngII (plasma:p=0.034, tissue:p<0.001), but were reduced by Siv (plasma:p=0.014, tissue:p=0.024). AngII increased aortic width (p=0.011) but was attenuated by co-administration of Siv (p=0.022). Moreover, Siv decreased the incidence of AAAs (p=0.009). Elastin fragmentation induced by AngII was reduced by Siv. Many inflammatory cells that were either CD68 or Gr-1 positive were observed in the AngII+saline group, whereas few inflammatory cells were accumulated in the AngII+Siv group. MMP-2 and MMP-9 were enhanced by AngII, but were reduced by Siv. In vitro, MMP-2 activity was induced by human NE (medium:p<0.001, cells:p=0.001), which was attenuated by co-incubation of Siv in medium (p<0.001) and protein of human aortic smooth muscle cells (p=0.001). CONCLUSION: Siv attenuated AngII-induced AAA through the inhibition of NE.

    DOI: 10.1093/ajh/hpad107

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  • ヘパリン起因性血小板減少症患者に対する内シャント造設術の経験

    藤井 泰宏, 廣田 真規, 加藤 源太郎, 竹内 英実, 黒子 洋介, 川畑 拓也, 小谷 恭弘, 小林 純子, 内田 治仁, 小松 弘明, 井上 善紀, 枝木 大治, 鈴木 浩之, 岸 良匡, 成宮 悠仁, 森岡 慧, 三浦 望, 杭ノ瀬 慶彦, 武田 直人, 笠原 真悟

    脈管学   63 ( Suppl. )   S178 - S178   2023.10

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  • 神経障害(2) 糖尿病神経障害におけるミエリン傷害

    片山 勝喜, 内田 治仁, 檜山 武史, 徐 珊珊, 栢野 功政, 松本 真実, 浦久保 秀俊, 大野 伸彦, 宮本 聡, 四方 賢一, 和田 淳

    糖尿病合併症   37 ( Suppl.1 )   149 - 149   2023.9

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  • Elderly Brothers With Fabry Disease Exhibiting Cardiac and Renal Manifestations

    Keiko Tanaka, Hitoshi Sugiyama, Hiroshi Morinaga, Akifumi Onishi, Yuzuki Kano, Hidemi Takeuchi, Kenji Tsuji, Motoki Kubo, Katsuyuki Tanabe, Haruhito A. Uchida, Kazufumi Nakamura, Jun Wada

    Annals of Internal Medicine: Clinical Cases   2 ( 5 )   2023.5

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    Publishing type:Research paper (scientific journal)   Publisher:American College of Physicians  

    DOI: 10.7326/aimcc.2022.1003

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  • 岡山市CKDネットワーク(OCKD-NET)2の登録時データ解析 OCKD-NET1との比較

    田中 景子, 内田 治仁, 大西 康博, 岡本 修吾, 竹内 英実, 辻 憲二, 田邊 克幸, 森永 裕士, 太田 康介, 丸山 啓輔, 大城 義之, 森岡 茂, 瀧上 慶一, 蒲生 直幸, 杉山 斉, 和田 淳

    日本腎臓学会誌   65 ( 3 )   268 - 268   2023.5

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  • 岡山市CKDネットワーク(OCKD-NET)におけるCKD病診連携12年後の追跡調査

    大西 康博, 内田 治仁, 田中 景子, 岡本 修吾, 竹内 英実, 辻 憲二, 田邊 克幸, 森永 裕士, 喜多村 真治, 前島 洋平, 太田 康介, 丸山 啓輔, 大城 義之, 森岡 茂, 瀧上 慶一, 蒲生 直幸, 杉山 斉, 和田 淳

    日本腎臓学会誌   65 ( 3 )   240 - 240   2023.5

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  • 医学生に対する腎セミナー開催についての検討

    辻 憲二, 岡本 修吾, 大西 康博, 田中 景子, 竹内 英実, 田邊 克幸, 森永 裕士, 内田 治仁, 喜多村 真治, 和田 淳

    日本腎臓学会誌   65 ( 3 )   326 - 326   2023.5

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  • The Effect of Medical Cooperation in the CKD Patients: 10-Year Multicenter Cohort Study. International journal

    Yasuhiro Onishi, Haruhito A Uchida, Yohei Maeshima, Yuka Okuyama, Nozomu Otaka, Haruyo Ujike, Keiko Tanaka, Hidemi Takeuchi, Kenji Tsuji, Masashi Kitagawa, Katsuyuki Tanabe, Hiroshi Morinaga, Masaru Kinomura, Shinji Kitamura, Hitoshi Sugiyama, Kosuke Ota, Keisuke Maruyama, Makoto Hiramatsu, Yoshiyuki Oshiro, Shigeru Morioka, Keiichi Takiue, Kazuyoshi Omori, Masaki Fukushima, Naoyuki Gamou, Hiroshi Hirata, Ryosuke Sato, Hirofumi Makino, Jun Wada

    Journal of personalized medicine   13 ( 4 )   2023.3

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    INTRODUCTION: While chronic kidney disease (CKD) is one of the most important contributors to mortality from non-communicable diseases, the number of nephrologists is limited worldwide. Medical cooperation is a system of cooperation between primary care physicians and nephrological institutions, consisting of nephrologists and multidisciplinary care teams. Although it has been reported that multidisciplinary care teams contribute to the prevention of worsening renal functions and cardiovascular events, there are few studies on the effect of a medical cooperation system. METHODS: We aimed to evaluate the effect of medical cooperation on all-cause mortality and renal prognosis in patients with CKD. One hundred and sixty-eight patients who visited the one hundred and sixty-three clinics and seven general hospitals of Okayama city were recruited between December 2009 and September 2016, and one hundred twenty-three patients were classified into a medical cooperation group. The outcome was defined as the incidence of all-cause mortality, or renal composite outcome (end-stage renal disease or 50% eGFR decline). We evaluated the effects on renal composite outcome and pre-ESRD mortality while incorporating the competing risk for the alternate outcome into a Fine-Gray subdistribution hazard model. RESULTS: The medical cooperation group had more patients with glomerulonephritis (35.0% vs. 2.2%) and less nephrosclerosis (35.0% vs. 64.5%) than the primary care group. Throughout the follow-up period of 5.59 ± 2.78 years, 23 participants (13.7%) died, 41 participants (24.4%) reached 50% decline in eGFR, and 37 participants (22.0%) developed end-stage renal disease (ESRD). All-cause mortality was significantly reduced by medical cooperation (sHR 0.297, 95% CI 0.105-0.835, p = 0.021). However, there was a significant association between medical cooperation and CKD progression (sHR 3.069, 95% CI 1.225-7.687, p = 0.017). CONCLUSION: We evaluated mortality and ESRD using a CKD cohort with a long-term observation period and concluded that medical cooperation might be expected to influence the quality of medical care in the patients with CKD.

    DOI: 10.3390/jpm13040582

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  • Serum sCD40L and IL-31 in Association with Early Phase of IgA Nephropathy. International journal

    Keiko Tanaka, Hitoshi Sugiyama, Hiroshi Morinaga, Masashi Kitagawa, Yuzuki Kano, Yasuhiro Onishi, Koki Mise, Katsuyuki Tanabe, Haruhito A Uchida, Jun Wada

    Journal of clinical medicine   12 ( 5 )   2023.3

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    BACKGROUND: IgA nephropathy (IgAN) is a major cause of chronic glomerulonephritis worldwide. T cell dysregulation has been reported to contribute to the pathogenesis of IgAN. Methods We measured a broad range of Th1, Th2 and Th17 cytokines in the serum of IgAN patients. We searched for significant cytokines, which were associated with clinical parameters and histological scores in IgAN patients. RESULTS: Among 15 cytokines, the levels of soluble CD40L (sCD40L) and IL-31 were higher in IgAN patients and were significantly associated with a higher estimated glomerular filtration rate (eGFR), a lower urinary protein to creatinine ratio (UPCR), and milder tubulointerstitial lesions (i.e., the early phase of IgAN). Multivariate analysis revealed that serum sCD40L was an independent determinant of a lower UPCR after adjustment for age, eGFR, and mean blood pressure (MBP). CD40, a receptor of sCD40L, has been reported to be upregulated on mesangial cells in IgAN. The sCD40L/CD40 interaction may directly induce inflammation in mesangial areas and may therefore be involved in the development of IgAN. CONCLUSIONS: The present study demonstrated the significance of serum sCD40L and IL-31 in the early phase of IgAN. Serum sCD40L may be a marker of the beginning of inflammation in IgAN.

    DOI: 10.3390/jcm12052023

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  • Association between Urinary Creatinine Excretion and Hypothyroidism in Patients with Chronic Kidney Disease. International journal

    Natsumi Matsuoka-Uchiyama, Kenji Tsuji, Kensaku Takahashi, Kazuhiko Fukushima, Hidemi Takeuchi, Shinji Kitamura, Kenichi Inagaki, Haruhito A Uchida, Jun Wada

    Diagnostics (Basel, Switzerland)   13 ( 4 )   2023.2

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    While hypothyroidism increases serum creatinine (Cr) levels, it is uncertain whether the elevation is mediated via a decline in the glomerular filtration rate (GFR) or the reflection of enhanced Cr production from the muscles or both. In the present study, we explored an association between urinary Cr excretion rate (CER) and hypothyroidism. A total of 553 patients with chronic kidney disease were enrolled in a cross-sectional study. Multiple linear regression analysis was performed to explore the association between hypothyroidism and urinary CER. The mean urinary CER was 1.01 ± 0.38 g/day and 121 patients (22%) had hypothyroidism. The multiple linear regression analysis revealed explanatory variables with urinary CER, including age, sex, body mass index, 24 h Cr clearance (24hrCcr), and albumin while hypothyroidism was not considered an independent explanatory variable. In addition, scatter plot analysis with regression fit line representing the association between estimated GFR calculated using s-Cr (eGFRcre) and 24hrCcr revealed that eGFRcre and 24hrCcr had strong correlations with each other in hypothyroid patients as well as euthyroid patients. Collectively, hypothyroidism was not considered an independent explanatory variable for urinary CER in the present study and eGFRcre is a useful marker to evaluate kidney function regardless of the presence of hypothyroidism.

    DOI: 10.3390/diagnostics13040669

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  • Efficacy and Safety of Esaxerenone in Hypertensive Patients with Diabetic Kidney Disease: A Multicenter, Open-Label, Prospective Study. International journal

    Haruhito A Uchida, Hirofumi Nakajima, Masami Hashimoto, Akihiko Nakamura, Tomokazu Nunoue, Kazuharu Murakami, Takeshi Hosoya, Kiichi Komoto, Takashi Taguchi, Takaaki Akasaka, Kazuhito Shiosakai, Kotaro Sugimoto, Jun Wada

    Advances in therapy   39 ( 11 )   5158 - 5175   2022.11

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    INTRODUCTION: Clinical data of esaxerenone in hypertensive patients with diabetic kidney disease (DKD) are lacking. We evaluated the efficacy and safety of esaxerenone in patients with DKD and an inadequate response to blood pressure (BP)-lowering treatment. METHODS: In this multicenter, open-label, prospective study, patients were divided into urinary albumin-to-creatinine ratio subcohorts (UACR < 30, 30 to < 300, and 300 to < 1000 mg/gCr). Esaxerenone was initiated at 1.25 mg/day and followed by incremental dose escalation based on BP and serum potassium level monitoring. The treatment period was 12 weeks. The primary endpoint was change in morning home systolic BP/diastolic BP (SBP/DBP) from baseline to end of treatment (EOT). Secondary endpoints included achievement rate of target BP, change in UACR from baseline, and safety. RESULTS: In total, 113 patients were enrolled. Morning home SBP/DBP significantly decreased from baseline to EOT in the total population (- 11.6/- 5.2 mmHg, both p < 0.001) and in all UACR subcohorts (all p < 0.001). The target BP achievement rate was 38.5%. Significant reductions in bedtime home and office BPs were also shown in the total population and all UACR subcohorts. UACR significantly improved from baseline to EOT in the total (- 50.9%, p < 0.001) and all UACR subcohorts (all p < 0.001). Incidence of serum potassium elevation as drug-related treatment emergent adverse events was 2.7%. The change from baseline in estimated glomerular filtration rate (eGFR) was - 4.8 mL/min/1.73 m2. CONCLUSION: Esaxerenone demonstrated a BP-lowering effect and improved albuminuria. The effects were consistent regardless of the severity of albuminuria without clinically relevant serum potassium elevation and eGFR reduction. CLINICAL TRIAL REGISTRATION: jRCTs06119002.

    DOI: 10.1007/s12325-022-02294-z

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  • The Beneficial Effect of Personalized Lifestyle Intervention in Chronic Kidney Disease Follow-Up Project for National Health Insurance Specific Health Checkup: A Five-Year Community-Based Cohort Study. International journal

    Hidemi Takeuchi, Haruhito A Uchida, Katsuyoshi Katayama, Natsumi Matsuoka-Uchiyama, Shugo Okamoto, Yasuhiro Onishi, Yuka Okuyama, Ryoko Umebayashi, Kodai Miyaji, Akiko Kai, Izumi Matsumoto, Keiko Taniguchi, Fukiko Yamashita, Tsutomu Emi, Hitoshi Sugiyama, Jun Wada

    Medicina (Kaunas, Lithuania)   58 ( 11 )   2022.10

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    Background and Objectives: Mimasaka city is a relatively small city with a population of 28,381, and an aging rate (≥65 years old) of 38.9%, where only one nephrology clinic is available. Since 2013, the city has conducted its own unique lifestyle intervention for the participants of the National Health Insurance specific medical health checkup, aiming to prevent the progression of chronic kidney disease (CKD) severity. Materials and Methods: The persons in National Health Insurance specific medical health checkup (40-74 years old) conducted in Mimasaka city in 2013, with eGFR less than 50 mL/min/1.73 m² or 50-90 mL/min/1.73 m² with urine dipstick protein 1+ or more, were registered for the CKD follow-up project, as high-risk subjects for advanced renal dysfunction. Municipal workers directly visited the subjects' homes to provide individual health guidance and encourage medical consultation. We aimed to examine the effect of home-visit intervention on the changes of renal function and related factors until 2017. Results: The number of the high-risk subjects who continuously received the health checkup until 2017 was 63, and only 23 (36.5%) visited a medical institution in the first year. The eGFR decreased by only 0.4 mL/min/1.73 m²/year, and the subjects with urinary protein 1+ or higher decreased significantly from 20 (31.7%) to 9 (14.3%) (p = 0.034) in the high-risk subjects. The changes in eGFR and urinary protein was almost in the same fashion regardless of their medical institution visits. Next, we examined the effects of various factors on ΔeGFR, the changes of eGFR from 2013 to 2017, by multivariate linear regression analysis. The effects of medical institution visit were not significant, and the degree of urinary protein (coefficient B: 4.503, β: 0.705, p &lt; 0.001), age (coefficient B: 4.753, β: 0.341, p = 0.004), and smoking (coefficient B: 5.878, β: 0.295, p = 0.031) had independent significant effects, indicating that they were the factors exacerbating the decrease in eGFR from the baseline. Conclusions: The personalized lifestyle intervention by home-visit in CKD follow-up project showed the possibility of beneficial effects on the deterioration of renal function. This may be an efficient method to change behavior in a small community with limited medical resources.

    DOI: 10.3390/medicina58111529

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  • Association between the patterns of large-vessel lesions and treatment outcomes in patients with large-vessel giant cell arteritis. International journal

    Takahiko Sugihara, Haruhito A Uchida, Hajime Yoshifuji, Yasuhiro Maejima, Taio Naniwa, Yasuhiro Katsumata, Takahiro Okazaki, Jun Ishizaki, Yohko Murakawa, Noriyoshi Ogawa, Hiroaki Dobashi, Tetsuya Horita, Yoshiya Tanaka, Shunsuke Furuta, Tsutomu Takeuchi, Yoshinori Komagata, Yoshikazu Nakaoka, Masayoshi Harigai

    Modern rheumatology   2022.10

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    OBJECTIVE: We aimed to identify associations between patterns of large-vessel lesions of large-vessel giant cell arteritis (LV-GCA) and treatment outcomes. METHODS: We extracted data on 68 newly-diagnosed patients with LV-GCA from a retrospective, multi-centric, nationwide registry of GCA patients treated with glucocorticoids between 2007 and 2014. Patients with aortic lesions were identified based on findings from contrast-enhanced computed tomography (CT), magnetic resonance imaging, or positron emission tomography-CT (group 2, n=49). Patients without aortic lesions were subdivided into LV-GCA with or without subclavian lesions defined as group 1 (n=9) or group 3 (n=10), respectively. Primary outcome evaluation was failure to achieve clinical remission by week 24 and/or relapse within 104 weeks. RESULTS: The mean age and proportion of patients with cranial lesions and polymyalgia rheumatica in group 2 was numerically lower than in the other two groups. Large-vessel lesions in group 3 included carotid, pulmonary, renal, hepatic or mesenteric lesions. The cumulative rate of poor treatment outcomes over two years was 11.1%, 55.3%, and 88.0% in groups 1, 2, and 3, respectively (by Kaplan-Meier analysis). The mean time to poor outcome was significantly different between the groups. CONCLUSIONS: Classification by subclavian and aortic lesions may be useful to determine treatment strategy.

    DOI: 10.1093/mr/roac122

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  • 異なる経過をたどった腎動脈狭窄を伴う高安動脈炎の2症例

    武本 梨佳, 内田 治仁, 戸田 洋伸, 岡本 修吾, 竹内 英実, 梅林 亮子, 大塚 文男, 伊藤 浩, 和田 淳

    脈管学   62 ( Suppl. )   S195 - S195   2022.10

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  • ベーチェット病により腎動脈狭窄症をきたした1例

    内田 治仁, 戸田 洋伸, 武本 梨佳, 岡本 修吾, 竹内 英実, 梅林 亮子, 和田 淳

    脈管学   62 ( Suppl. )   S182 - S183   2022.10

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  • 当院における腎移植後コロナウイルス感染症の臨床経過

    吉永 香澄, 関戸 崇了, 丸山 雄樹, 山野井 友昭, 西村 慎吾, 竹内 英実, 田邉 克幸, 森永 裕士, 内田 治仁, 和田 淳, 枝村 康平, 小林 知子, 小林 泰之, 荒木 元朗

    移植   57 ( 総会臨時 )   262 - 262   2022.10

  • 異なる経過をたどった腎動脈狭窄を伴う高安動脈炎の2症例

    武本 梨佳, 内田 治仁, 戸田 洋伸, 岡本 修吾, 竹内 英実, 梅林 亮子, 大塚 文男, 伊藤 浩, 和田 淳

    脈管学   62 ( Suppl. )   S195 - S195   2022.10

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  • The association between hypothyroidism and proteinuria in patients with chronic kidney disease: a cross-sectional study. International journal

    Natsumi Matsuoka-Uchiyama, Kenji Tsuji, Yizhen Sang, Kensaku Takahashi, Kazuhiko Fukushima, Hidemi Takeuchi, Kenichi Inagaki, Haruhito A Uchida, Shinji Kitamura, Hitoshi Sugiyama, Jun Wada

    Scientific reports   12 ( 1 )   14999 - 14999   2022.9

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    Hypothyroidism is known to be correlated with kidney function and nephrotic range proteinuria. However, it is uncertain whether non-nephrotic proteinuria is associated with hypothyroidism. This study aimed to evaluate the association of proteinuria and hypothyroidism in chronic kidney disease (CKD) patients. We conducted a cross-sectional study composed of 421 CKD patients in a single hospital with measurements of 24-h urine protein excretion (UP) and thyroid function tests. Spearman correlation analysis revealed that 24-h Cr clearance (24hrCcr) was positively (r = 0.273, p < 0.001) and UP was negatively (r = - 0.207, p < 0.001) correlated with free triiodothyronine. Frequency distribution analysis stratified by CKD stage and UP for hypothyroidism revealed that the prevalence of hypothyroidism was higher among participants with higher CKD stage and nephrotic range proteinuria. Multivariate logistic regression analysis revealed that 24hrCcr and UP were significantly correlated with hypothyroidism (24hrCcr/10 mL/min decrease: odds ratio [OR], 1.29; 95% confidence interval [CI], 1.18-1.41; UP/1 g increase: OR, 1.10; 95% CI, 1.03-1.17). In addition, nephrotic range proteinuria, but not moderate UP (UP: 1.5-3.49 g/day), was significantly correlated with hypothyroidism compared to UP < 0.5 g/day. In summary, decreased kidney function and nephrotic range proteinuria, not non-nephrotic proteinuria, are independently associated with the hypothyroidism.

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  • Simulation for ultrasound-guided renal biopsy using boiled egg. International journal

    Kenji Tsuji, Shinji Kitamura, Haruhito A Uchida, Jun Wada

    Nephrology (Carlton, Vic.)   27 ( 9 )   753 - 757   2022.9

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    Real-time ultrasound-guided renal biopsy is generally applied to diagnose multiple kidney diseases. A practical simulation model is desired since it is an invasive technique with higher risks of complications such as bleeding. We developed a simple simulation tool for ultrasound-guided renal biopsy using boiled eggs. Boiled chicken eggs were embedded in the agar, and a biopsy simulation was performed using a real-time ultrasound-guided technique as the renal biopsy simulator by trainees and biopsy-proficient nephrologists, and the feedback from the participants was obtained. The ultrasonographic evaluation revealed a clear contrast between egg yolk and white, which clearly mimicked the kidney cortex and medulla region. In addition, we observed the needle entering the egg white under needle penetration, and we obtained the biopsy core consisting of egg white. As for the simulations, all the participants succeeded in obtaining the appropriate samples. A total of 92% of the trainees agreed that the simulation could reduce their fears of performing renal biopsies in patients. In addition, all the trainees and biopsy-proficient nephrologists recommend using the simulator for trainees before conducting renal biopsies on patients. The total cost of the simulator was low (<USD 1/simulator). Collectively, our simulation tool using boiled eggs may be a good candidate for practical simulation models of renal biopsy.

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  • Establishing clinical remission criteria and the framework of a treat-to-target algorithm for Takayasu arteritis: Results of a Delphi exercise carried out by an expert panel of the Japan Research Committee of the Ministry of Health, Labour and Welfare for intractable vasculitis. International journal

    Takahiko Sugihara, Yoshikazu Nakaoka, Haruhito A Uchida, Hajime Yoshifuji, Yasuhiro Maejima, Yoshiko Watanabe, Eisuke Amiya, Kazuo Tanemoto, Tetsuro Miyata, Natsuka Umezawa, Yusuke Manabe, Jun Ishizaki, Tsuyoshi Shirai, Hiroko Nagafuchi, Hitoshi Hasegawa, Takako Miyamae, Hiroaki Niiro, Shuichi Ito, Tomonori Ishii, Mitsuaki Isobe, Masayoshi Harigai

    Modern rheumatology   32 ( 5 )   930 - 937   2022.8

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    OBJECTIVE: To develop a proposal for remission criteria and a framework for a treat-to-target (T2T) algorithm for Takayasu arteritis (TAK). METHODS: A study group of the large-vessel vasculitis group of the Japanese Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis (JPVAS) consists of 10 rheumatologists, 5 cardiologists, 1 nephrologist, 1 vascular surgeon, 1 cardiac surgeon, and 2 pediatric rheumatologists. A Delphi survey of remission criteria items was circulated among the study group over 4 reiterations. To develop the T2T algorithm, the study group conducted four face-to-face meetings and two rounds of Delphi together with 3 patients. RESULTS: Initial literature review resulted in a list of 117 candidate items for remission criteria, of which 56 items with a mean score of ≥4 (0-5) were extracted including disease activity domains and treatment/comorbidity domains. The study group provided six overarching principles for the T2T algorithm, two recommendations on treatment goals, five on evaluation of disease activity and imaging findings including PET-CT, and two on treatment intensification. CONCLUSIONS: We developed a T2T algorithm and proposals for standardized remission criteria by means of a Delphi exercise. These will guide future evaluation of different TAK treatment regimens.

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  • Edaravone Attenuated Angiotensin II-Induced Atherosclerosis and Abdominal Aortic Aneurysms in Apolipoprotein E-Deficient Mice. International journal

    Haruhito A Uchida, Tetsuharu Takatsuka, Yoshiko Hada, Ryoko Umebayashi, Hidemi Takeuchi, Kenichi Shikata, Venkateswaran Subramanian, Alan Daugherty, Jun Wada

    Biomolecules   12 ( 8 )   2022.8

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    BACKGROUND: The aim of the study was to define whether edaravone, a free-radical scavenger, influenced angiotensin II (AngII)-induced atherosclerosis and abdominal aortic aneurysms (AAAs) formation. METHODS: Male apolipoprotein E-deficient mice (8-12 weeks old) were fed with a normal diet for 5 weeks. Either edaravone (10 mg/kg/day) or vehicle was injected intraperitoneally for 5 weeks. After 1 week of injections, mice were infused subcutaneously with either AngII (1000 ng/kg/min, n = 16-17 per group) or saline (n = 5 per group) by osmotic minipumps for 4 weeks. RESULTS: AngII increased systolic blood pressure equivalently in mice administered with either edaravone or saline. Edaravone had no effect on plasma total cholesterol concentrations and body weights. AngII infusion significantly increased ex vivo maximal diameters of abdominal aortas and en face atherosclerosis but was significantly attenuated by edaravone administration. Edaravone also reduced the incidence of AngII-induced AAAs. In addition, edaravone diminished AngII-induced aortic MMP-2 activation. Quantitative RT-PCR revealed that edaravone ameliorated mRNA abundance of aortic MCP-1 and IL-1β. Immunostaining demonstrated that edaravone attenuated oxidative stress and macrophage accumulation in the aorta. Furthermore, edaravone administration suppressed thioglycolate-induced mice peritoneal macrophages (MPMs) accumulation and mRNA abundance of MCP-1 in MPMs in male apolipoprotein E-deficient mice. In vitro, edaravone reduced LPS-induced mRNA abundance of MCP-1 in MPMs. CONCLUSIONS: Edaravone attenuated AngII-induced AAAs and atherosclerosis in male apolipoprotein E-deficient mice via anti-oxidative action and anti-inflammatory effect.

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  • Cilostazol Attenuates AngII-Induced Cardiac Fibrosis in apoE Deficient Mice. International journal

    Yoshiko Hada, Haruhito A Uchida, Ryoko Umebayashi, Masashi Yoshida, Jun Wada

    International journal of molecular sciences   23 ( 16 )   2022.8

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    Cardiac fibrosis is characterized by the net accumulation of extracellular matrix in the myocardium and is an integral component of most pathological cardiac conditions. Cilostazol, a selective inhibitor of phosphodiesterase type III with anti-platelet, anti-mitogenic, and vasodilating properties, is widely used to treat the ischemic symptoms of peripheral vascular disease. Here, we investigated whether cilostazol has a protective effect against Angiotensin II (AngII)-induced cardiac fibrosis. Male apolipoprotein E-deficient mice were fed either a normal diet or a diet containing cilostazol (0.1% wt/wt). After 1 week of diet consumption, the mice were infused with saline or AngII (1000 ng kg-1 min-1) for 28 days. AngII infusion increased heart/body weight ratio (p &lt; 0.05), perivascular fibrosis (p &lt; 0.05), and interstitial cardiac fibrosis (p &lt; 0.0001), but were significantly attenuated by cilostazol treatment (p &lt; 0.05, respectively). Cilostazol also reduced AngII-induced increases in fibrotic and inflammatory gene expression (p &lt; 0.05, respectively). Furthermore, cilostazol attenuated both protein and mRNA abundance of osteopontin induced by AngII in vivo. In cultured human cardiac myocytes, cilostazol reduced mRNA expression of AngII-induced osteopontin in dose-dependent manner. This reduction was mimicked by forskolin treatment but was cancelled by co-treatment of H-89. Cilostazol attenuates AngII-induced cardiac fibrosis in mice through activation of the cAMP-PKA pathway.

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  • IL-17A promotes vascular calcification in an ex vivo murine aorta culture. International journal

    Sumie Hiramatsu-Asano, Tomoyuki Mukai, Takahiko Akagi, Haruhito A Uchida, Shunichi Fujita, Kazuhisa Nakano, Yoshitaka Morita

    Biochemical and biophysical research communications   604   83 - 87   2022.5

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    BACKGROUND: Vascular calcification is characterized by mineral deposition in the vasculature, which is triggered by chronic systemic inflammation, including psoriasis. Psoriasis is an IL-17A-mediated inflammatory skin disease that is associated with exacerbated vascular calcification and high cardiovascular mortality. Although previous studies have shown that IL-17A induces vascular dysfunction in murine psoriasis models, it has not been clarified whether IL-17A induces vascular calcification. In this study, we investigated the potential vascular calcification-inducing effect of IL-17A in an ex vivo culture system. METHODS: Thoracic and abdominal aortas from mice were cultured in a medium supplemented with inorganic phosphate and were treated with inflammatory cytokines (IL-1β, TNF-α, IL-6, and IL-17A). Vascular calcification was determined using micro-computed tomography (CT) and histological analyses. RESULTS: IL-1β, TNF-α, and IL-6 did not significantly promote vascular calcification, whereas IL-17A significantly accelerated vascular calcification of the aorta, as indicated by the increased mineralized volume based on micro-CT analysis. Micro-CT and histological analyses also revealed that the promoting effect of IL-17A on vascular calcification was concentration dependent. CONCLUSIONS: IL-17A significantly promoted vascular calcification in ex vivo cultured aortas, which suggests that this mechanism is involved in the increased risk of cardiovascular events in IL-17A-mediated inflammatory diseases.

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  • 岡山市CKDネットワーク(OCKD-NET)におけるCKD病診連携11年後の追跡調査

    大西 康博, 内田 治仁, 竹内 英実, 田中 景子, 辻 憲二, 田邊 克幸, 森永 裕士, 木野村 賢, 喜多村 真治, 前島 洋平, 杉山 斉, 太田 康介, 丸山 啓輔, 大城 義之, 森岡 茂, 瀧上 慶一, 蒲生 直幸, 和田 淳

    日本腎臓学会誌   64 ( 3 )   234 - 234   2022.5

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  • ゆで卵を用いた模擬腎生検 コロンブスの卵

    辻 憲二, 田中 景子, 竹内 英実, 田邊 克幸, 森永 裕士, 木野村 賢, 内田 治仁, 喜多村 真治, 杉山 斉, 和田 淳

    日本腎臓学会誌   64 ( 3 )   297 - 297   2022.5

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  • 加齢による筋萎縮に対するクロロゲン酸の保護効果

    内田 治仁, 秦 昌紫子, 岡本 修吾, 片山 勝喜, 竹内 英実, 和田 淳

    日本老年医学会雑誌   59 ( Suppl. )   151 - 151   2022.5

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  • ゆで卵を用いた模擬腎生検 コロンブスの卵

    辻 憲二, 田中 景子, 竹内 英実, 田邊 克幸, 森永 裕士, 木野村 賢, 内田 治仁, 喜多村 真治, 杉山 斉, 和田 淳

    日本腎臓学会誌   64 ( 3 )   297 - 297   2022.5

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  • 岡山市CKDネットワーク(OCKD-NET)におけるCKD病診連携11年後の追跡調査

    大西 康博, 内田 治仁, 竹内 英実, 田中 景子, 辻 憲二, 田邊 克幸, 森永 裕士, 木野村 賢, 喜多村 真治, 前島 洋平, 杉山 斉, 太田 康介, 丸山 啓輔, 大城 義之, 森岡 茂, 瀧上 慶一, 蒲生 直幸, 和田 淳

    日本腎臓学会誌   64 ( 3 )   234 - 234   2022.5

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  • Silica-associated systemic lupus erythematosus with lupus nephritis and lupus pneumonitis: A case report and a systematic review of the literature. International journal

    Kazuhiko Fukushima, Haruhito A Uchida, Yasuko Fuchimoto, Tomoyo Mifune, Mayu Watanabe, Kenji Tsuji, Katsuyuki Tanabe, Masaru Kinomura, Shinji Kitamura, Yosuke Miyamoto, Sae Wada, Taisaku Koyanagi, Hitoshi Sugiyama, Takumi Kishimoto, Jun Wada

    Medicine   101 ( 7 )   e28872   2022.2

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    INTRODUCTION: Several epidemiological studies have shown that silica exposure triggers the onset of systemic lupus erythematosus (SLE); however, the clinical characteristics of silica-associated SLE have not been well studied. PATIENT CONCERNS: A 67-year-old man with silicosis visited a primary hospital because of a fever and cough. His respiratory condition worsened, regardless of antibiotic medication, and he was referred to our hospital. DIAGNOSIS: The patient showed leukopenia, lymphopenia, serum creatinine elevation with proteinuria and hematuria, decreased serum C3 level, and was positive for anti-double stranded DNA antibody, anti-nuclear antibody, and direct Coombs test. He was diagnosed with SLE. Renal biopsy was performed, and the patient was diagnosed with lupus nephritis (class IV-G(A/C) + V defined by the International Society of Nephrology/Renal Pathology Society classification). Computed tomography revealed acute interstitial pneumonitis, bronchoalveolar lavage fluid showed elevation of the lymphocyte fraction, and he was diagnosed with lupus pneumonitis. INTERVENTIONS: Prednisolone (50 mg/day) with intravenous cyclophosphamide (500 mg/body) were initiated. OUTCOMES: The patient showed a favorable response to these therapies. He was discharged from our hospital and received outpatient care with prednisolone slowly tapered off. He had cytomegalovirus and herpes zoster virus infections during treatment, which healed with antiviral therapy. REVIEW: We searched for the literature on sSLE, and selected 11 case reports and 2 population-based studies. The prevalence of SLE manifestations in sSLE patients were comparative to that of general SLE, particularly that of elderly-onset SLE. Our renal biopsy report and previous reports indicate that lupus nephritis of sSLE patients show as various histological patterns as those of general SLE patients. Among the twenty sSLE patients reported in the case articles, three patients developed lupus pneumonitis and two of them died of it. Moreover, two patients died of bacterial pneumonia, one developed aspergillus abscesses, one got pulmonary tuberculosis, and one developed lung cancer. CONCLUSION: Close attention is needed, particularly for respiratory system events and infectious diseases, when treating patients with silica-associated SLE using immunosuppressive therapies.

    DOI: 10.1097/MD.0000000000028872

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  • Circulating GPIHBP1 levels and microvascular complications in patients with type 2 diabetes: A cross-sectional study. International journal

    Naoko Kurooka, Jun Eguchi, Kazutoshi Murakami, Shinji Kamei, Toru Kikutsuji, Sakiko Sasaki, Akiho Seki, Satoshi Yamaguchi, Ichiro Nojima, Mayu Watanabe, Chigusa Higuchi, Akihiro Katayama, Haruhito A Uchida, Atsuko Nakatsuka, Kenichi Shikata, Jun Wada

    Journal of clinical lipidology   16 ( 2 )   237 - 245   2022.1

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    BACKGROUND: Glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 (GPIHBP1) plays a crucial role in lipolytic processing. Previous studies have shown that GPIHBP1 mutations cause severe hypertriglyceridemia and that serum GPIHBP1 levels are marginally higher in patients with coronary heart disease; however, the role of GPIHBP1 in type 2 diabetes mellitus (T2DM) remains unknown. OBJECTIVE: We investigated the association between circulating GPIHBP1 levels and the prevalence of microvascular complications in T2DM. METHODS: A total of 237 subjects with T2DM and 235 non-diabetic control subjects were enrolled in this study. Their serum GPIHBP1 levels were evaluated using ELISA assays. RESULTS: Circulating GPIHBP1 levels were higher in patients with T2DM (952.7 pg/mL [761.3-1234.6], p < 0.0001) than in non-diabetic subjects (700.6 [570.8-829.6]), but did not differ in T2DM patients with or without hypertriglyceridemia. Serum GPIHBP1 levels were significantly higher in patients with T2DM with diabetic retinopathy (DR), diabetic nephropathy (DN), and microvascular complications than in those without these complications. Multivariable logistic regression and receiver operating characteristic (ROC) curve analyses revealed that the presence of microvascular complications, but not macrovascular complications, was independently associated with serum GPIHBP1 levels, which could predict the presence of diabetic microvascular complications. CONCLUSIONS: Elevated GPIHBP1 levels are associated with microvascular complications in T2DM and may help to predict their progression.

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  • Prevalence of Chronic Kidney Disease and Variation of Its Risk Factors by the Regions in Okayama Prefecture. International journal

    Ryoko Umebayashi, Haruhito Adam Uchida, Natsumi Matsuoka-Uchiyama, Hitoshi Sugiyama, Jun Wada

    Journal of personalized medicine   12 ( 1 )   2022.1

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    OBJECTIVE: The prevention of chronic kidney disease (CKD) progression is an important issue from health and financial perspectives. We conducted a single-year cross-sectional study to clarify the prevalence of CKD and its risk factors along with variations in these factors among five medical regions in Okayama Prefecture, Japan. METHODS AND RESULTS: Data concerning the renal function and proteinuria as well as other CKD risk factors were obtained from the database of the Japanese National Health Insurance. The proportion of CKD patients at an increased risk of progression to end-stage renal disease (ESRD), classified as orange and red on the CKD heatmap, ranged from 6-9% and did not vary significantly by the regions. However, the causes of the increased severity differed between regions where renal dysfunction was predominant and regions where there were many patients with proteinuria. CKD risk factors, such as diabetes mellitus, hypertension, hyper low-density lipoprotein-cholesterolemia, obesity, smoking and lack of exercise, also differed among these regions, suggesting that different regions need tailored interventions that suit the characteristics of the region, such as an increased health checkup ratio, dietary guidance and promotion of exercise opportunities. CONCLUSIONS: Approximately 6-9% of people are at an increased risk of developing ESRD (orange or red on a CKD heatmap) among the population with National Health Insurance in Okayama Prefecture. The underlying health problems that cause CKD may differ among the regions. Thus, it is necessary to consider intervention methods for preventing CKD progression that are tailored to each region's health problems.

    DOI: 10.3390/jpm12010097

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  • The Association of Postprandial Triglyceride Variability with Renal Dysfunction and Microalbuminuria in Patients with Type 2 Diabetic Mellitus: A Retrospective and Observational Study. International journal

    Natsumi Matsuoka-Uchiyama, Haruhito A Uchida, Shugo Okamoto, Yasuhiro Onishi, Katsuyoshi Katayama, Mariko Tsuchida-Nishiwaki, Hidemi Takeuchi, Rika Takemoto, Yoshiko Hada, Ryoko Umebayashi, Naoko Kurooka, Kenji Tsuji, Jun Eguchi, Hirofumi Nakajima, Kenichi Shikata, Jun Wada

    Journal of diabetes research   2022   3157841 - 3157841   2022

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    OBJECTIVE: We examined whether or not day-to-day variations in lipid profiles, especially triglyceride (TG) variability, were associated with the exacerbation of diabetic kidney disease. METHODS: We conducted a retrospective and observational study. First, 527 patients with type 2 diabetes mellitus (DM) who had had their estimated glomerular filtration rate (eGFR) checked every 6 months since 2012 for over 5 years were registered. Variability in postprandial TG was determined using the standard deviation (SD), SD adjusted (Adj-SD) for the number of measurements, and maximum minus minimum difference (MMD) during the first three years of follow-up. The endpoint was a ≥40% decline from baseline in the eGFR, initiation of dialysis or death. Next, 181 patients who had no micro- or macroalbuminuria in February 2013 were selected from among the 527 patients for an analysis. The endpoint was the incidence of microalbuminuria, initiation of dialysis, or death. RESULTS: Among the 527 participants, 110 reached a ≥40% decline from baseline in the eGFR or death. The renal survival was lower in the higher-SD, higher-Adj-SD, and higher-MMD groups than in the lower-SD, lower-Adj-SD, and lower-MMD groups, respectively (log-rank test p = 0.0073, 0.0059, and 0.0195, respectively). A lower SD, lower Adj-SD, and lower MMD were significantly associated with the renal survival in the adjusted model (hazard ratio, 1.62, 1.66, 1.59; 95% confidence intervals, 1.05-2.53, 1.08-2.58, 1.04-2.47, respectively). Next, among 181 participants, 108 developed microalbuminuria or death. The nonincidence of microalbuminuria was lower in the higher-SD, higher-Adj-SD, and higher-MMD groups than in the lower-SD, lower-Adj-SD, and lower-MMD groups, respectively (log-rank test p = 0.0241, 0.0352, and 0.0474, respectively). CONCLUSIONS: Postprandial TG variability is a novel risk factor for eGFR decline and the incidence of microalbuminuria in patients with type 2 DM.

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  • Development of Urinary Diagnostic Biomarker for IgA Nephropathy by Lectin Microarray. International journal

    Yasuhiro Onishi, Koki Mise, Chieko Kawakita, Haruhito A Uchida, Hitoshi Sugiyama, Ryosuke Sugawara, Satoshi Yamaguchi, Michihiro Yoshida, Toshiharu Mitsuhashi, Masao Yamada, Jun Hirabayashi, Jun Wada

    American journal of nephrology   53 ( 1 )   10 - 20   2022

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    INTRODUCTION: The pathogenic roles of aberrantly glycosylated IgA1 have been reported. However, it is unexplored whether the profiling of urinary glycans contributes to the diagnosis of IgAN. METHODS: We conducted a retrospective study enrolling 493 patients who underwent renal biopsy at Okayama University Hospital between December 2010 and September 2017. We performed lectin microarray in urine samples and investigated whether c-statistics of the reference standard diagnosis model employing hematuria, proteinuria, and serum IgA were improved by adding the urinary glycan intensity. RESULTS: Among 45 lectins, 3 lectins showed a significant improvement of the models: Amaranthus caudatus lectin (ACA) with the difference of c-statistics 0.038 (95% CI: 0.019-0.058, p < 0.001), Agaricus bisporus lectin (ABA) 0.035 (95% CI: 0.015-0.055, p < 0.001), and Maackia amurensis lectin (MAH) 0.035 (95% CI: 0.015-0.054, p < 0.001). In 3 lectins, each signal plus reference standard showed good reclassification (category-free NRI and relative IDI) and good model fitting associated with the improvement of AIC and BIC. Stratified by eGFR, the discriminatory ability of ACA plus reference standard was maintained, suggesting the robust renal function-independent diagnostic performance of ACA. By decision curve analysis, there was a 3.45% net benefit by adding urinary glycan intensity of ACA to the reference standard at the predefined threshold probability of 40%. CONCLUSIONS: The reduction of Gal(β1-3)GalNAc (T-antigen), Sia(α2-3)Gal(β1-3)GalNAc (Sialyl T), and Sia(α2-3)Gal(β1-3)Sia(α2-6)GalNAc (disialyl-T) was suggested by binding specificities of 3 lectins. C1GALT1 and COSMC were responsible for the biosynthesis of these glycans, and they were known to be downregulated in IgAN. The urinary glycan analysis by ACA is a useful and robust noninvasive strategy for the diagnosis of IgAN.

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  • Masked CKD in hyperthyroidism and reversible CKD status in hypothyroidism. International journal

    Natsumi Uchiyama-Matsuoka, Kenji Tsuji, Haruhito A Uchida, Shinji Kitamura, Yoshihiko Itoh, Yuki Nishiyama, Eisaku Morimoto, Satoshi Fujisawa, Tomohiro Terasaka, Takayuki Hara, Kanako Ogura-Ochi, Kenichi Inagaki, Jun Wada

    Frontiers in endocrinology   13   1048863 - 1048863   2022

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    INTRODUCTION: While it is well known that thyroid function may affect kidney function, the transition of the chronic kidney disease (CKD) status before and after treatment for thyroid disorders, as well as the factors affecting this change, remains to be explored. In the present study, we focused on the change in kidney function and their affecting factors during the treatment for both hyperthyroidism and hypothyroidism. METHODS: Eighty-eight patients with hyperthyroidism and fifty-two patients with hypothyroidism were enrolled in a retrospective and longitudinal case series to analyze the changes in kidney function and their affecting factors after treatment for thyroid disorders. RESULTS: Along with the improvement of thyroid function after treatment, there was a significant decrease in estimated glomerular filtration rate (eGFR) in hyperthyroidism (an average ΔeGFR of -41.1 mL/min/1.73 m2) and an increase in eGFR in hypothyroidism (an average ΔeGFR of 7.1 mL/min/1.73 m2). The multiple linear regression analysis revealed that sex, eGFR, free thyroxine (FT4) and free triiodothyronine (FT3) could be considered independent explanatory variables for ΔeGFR in hyperthyroidism, while age, eGFR, and FT3 were detected as independent explanatory variables in hypothyroidism. In addition, the stratification by kidney function at two points, pre- and post-treatment for thyroid disorders, revealed that 4.5% of the participants with hyperthyroidism were pre-defined as non-CKD and post-defined as CKD, indicating the presence of "masked" CKD in hyperthyroidism. On the other hand, 13.5% of the participants with hypothyroidism presented pre-defined CKD and post-defined non-CKD, indicating the presence of "reversible" CKD status in hypothyroidism. CONCLUSIONS: We uncovered the population of masked CKD in hyperthyroidism and reversible CKD status in hypothyroidism, thereby re-emphasizing the importance of a follow-up to examine kidney function after treatment for hyperthyroidism and the routine evaluation of thyroid function in CKD patients as well as the appropriate hormone therapy if the patient has hypothyroidism.

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  • 当院における75歳以上の患者での24時間自由行動下血圧の検討

    大高 望, 内田 治仁, 岡本 修吾, 大西 康博, 竹内 英実, 和田 淳

    日本老年医学会雑誌   58 ( 4 )   659 - 659   2021.10

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  • 超高齢者(oldest-old)における腎代替療法選択を行った2例

    大西 康博, 内田 治仁, 大高 望, 竹内 英実, 森永 裕士, 杉山 斉, 吉田 賢司, 和田 淳

    日本老年医学会雑誌   58 ( 4 )   657 - 657   2021.10

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  • PADは維持透析患者におけるフレイルを促進し予後不良とさせる

    竹内 英実, 内田 治仁, 大高 望, 和田 淳

    日本老年医学会雑誌   58 ( 4 )   656 - 656   2021.10

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  • クロロゲン酸の血管老化に対する保護効果

    内田 治仁, 秦 昌紫子, 大高 望, 竹内 英実, 和田 淳

    日本老年医学会雑誌   58 ( 4 )   656 - 656   2021.10

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  • 2型糖尿病患者における血中GPIHBP1濃度の臨床的意義

    黒岡 直子, 江口 潤, 内田 治仁, 村上 和敏, 亀井 信二, 菊辻 徹, 佐々木 佐起子, 関 明穂, 和田 淳

    日本動脈硬化学会総会プログラム・抄録集   53回   228 - 228   2021.10

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  • 尿中クレアチニン(Cr)排泄量低下が健康関連QOLに与える影響についての検討

    大西 康博, 内田 治仁, 杉山 斉, 浅野 健一郎, 徳増 裕宣, 和田 淳

    日本老年医学会雑誌   58 ( 4 )   657 - 657   2021.10

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  • Total vascular resistance, augmentation index, and augmentation pressure increase in patients with peripheral artery disease. International journal

    Rika Takemoto, Haruhito A Uchida, Hironobu Toda, Ken Okada, Fumio Otsuka, Hiroshi Ito, Jun Wada

    Medicine   100 ( 32 )   e26931   2021.8

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    ABSTRACT: Peripheral arterial disease (PAD) is one of major vascular diseases which frequently coexists with coronary arterial disease and cerebrovascular disease. The patients with PAD have a poor prognosis when it progresses. A new blood pressure testing device enables to simultaneously measure brachial blood pressure (BP), central BP, and several vascular parameters, with easy and non-invasive, in a short time. Here, we aimed to evaluate these arterial stiffness parameters in patients with PAD.In this study, 243 consecutive patients who were suspected of having PAD and referred to our hospital from September 2016 to June 2019, were registered. Several parameters, such as brachial BP, central BP, aortic pulse wave velocity (aPWV), total vascular resistance (TVR), augmentation index (AI) and augmentation pressure (AP), were determined by Mobil-O-Graph. Ankle-brachial pressure index (ABI) was used to define PAD (ABI ≤ 0.9 as PAD). The relationship between PAD and central BP, aPWV, TVR, AI, or AP were investigated.One hundred sixty-two patients (67%) were categorized as the PAD group and 81 patients (33%) as the non-PAD group. In the PAD group, the systolic brachial BP and central systolic BP were significantly higher than those in the non-PAD group (138 ± 24 mmHg vs 131 ± 19 mmHg, P < .05, 125 ± 22 mmHg vs 119 ± 18 mmHg, P < .05, respectively). TVR, AI, and AP were significantly higher in the PAD group (1785 ± 379 dyn s/cm5 vs 1661 ± 317 dyn s/cm5, P < .05, 26.2 ± 13.0% vs 22.2 ± 13.3%, P < .05, 13.5 ± 9.4 mmHg vs 10.7 ± 7.2 mmHg, P < .05, respectively). No significant differences in diastolic BP, central diastolic BP, and aPWV were found between the groups. Multivariate logistic regression analysis revealed that PAD was significantly associated with TVR, AI, and AP (P < .05, respectively).TVR/AP/AI were significantly higher in the PAD group than in the non-PAD group.

    DOI: 10.1097/MD.0000000000026931

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  • Association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study. International journal

    Mariko Tsuchida-Nishiwaki, Haruhito A Uchida, Hidemi Takeuchi, Noriyuki Nishiwaki, Yohei Maeshima, Chie Saito, Hitoshi Sugiyama, Jun Wada, Ichiei Narita, Tsuyoshi Watanabe, Seiichi Matsuo, Hirofumi Makino, Akira Hishida, Kunihiro Yamagata

    Scientific reports   11 ( 1 )   14990 - 14990   2021.7

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    It is well-known that hypertension exacerbates chronic kidney disease (CKD) progression, however, the optimal target blood pressure (BP) level in patients with CKD remains unclear. This study aimed to assess the optimal BP level for preventing CKD progression. The risk of renal outcome among different BP categories at baseline as well as 1 year after, were evaluated using individual CKD patient data aged between 40 and 74 years from FROM-J [Frontier of Renal Outcome Modifications in Japan] study. The renal outcome was defined as ≥ 40% reduction in estimated glomerular filtration rate to < 60 mL/min/1.73 m2, or a diagnosis of end stage renal disease. Regarding baseline BP, the group of systolic BP (SBP) 120-129 mmHg had the lowest risk of the renal outcome, which increased more than 60% in SBP ≥ 130 mmHg group. A significant increase in the renal outcome was found only in the group of diastolic BP ≥ 90 mmHg. The group of BP < 130/80 mmHg had a benefit for lowering the risk regardless of the presence of proteinuria, and it significantly reduced the risk in patients with proteinuria. Achieving SBP level < 130 mmHg after one year resulted in a 42% risk reduction in patients with SBP level ≥ 130 mmHg at baseline. Targeting SBP level < 130 mmHg would be associated with the preferable renal outcome.Clinical Trial Registration-URL: https://www.umin.ac.jp/ctr/ . Unique identifier: UMIN000001159 (16/05/2008).

    DOI: 10.1038/s41598-021-94467-z

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  • 透析患者におけるCVDとフレイルの関係

    竹内 英実, 内田 治仁, 大高 望, 奥山 由加, 梅林 亮子, 杉山 斉, 和田 淳

    日本腎臓学会誌   63 ( 4 )   431 - 431   2021.6

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  • 慢性腎臓病における貧血管理 Kakusyo 3C Studyからの検討

    奥山 由加, 内田 治仁, 大高 望, 竹内 英実, 辻 憲二, 田邊 克幸, 木野村 賢, 吉田 賢司, 前島 洋平, 杉山 斉, 伊藤 浩, 和田 淳

    日本腎臓学会誌   63 ( 4 )   474 - 474   2021.6

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  • 中四国地域におけるCKDおよびCVDの関連に関するコホート研究 Kakusyo 3C Studyのイベント解析

    大高 望, 内田 治仁, 竹内 英実, 辻 憲二, 田邊 克幸, 木野村 賢, 吉田 賢司, 前島 洋平, 杉山 斉, 伊藤 浩, 和田 淳

    日本腎臓学会誌   63 ( 4 )   464 - 464   2021.6

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  • 岡山市CKDネットワーク(OCKD-NET)におけるCKD病診連携10年後の追跡調査

    大西 康博, 内田 治仁, 大高 望, 竹内 英実, 辻 憲二, 田邊 克幸, 森永 裕士, 木野村 賢, 喜多村 真治, 前島 洋平, 杉山 斉, 太田 康介, 丸山 啓輔, 大城 義之, 森岡 茂, 瀧上 慶一, 蒲生 直幸, 和田 淳

    日本腎臓学会誌   63 ( 4 )   513 - 513   2021.6

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  • 甲状腺機能低下症とCKDの関連性におけるCr代謝の影響についての検討

    内山 奈津実, 辻 憲二, 喜多村 真治, 稲垣 兼一, 内田 治仁, 杉山 斉, 和田 淳

    日本腎臓学会誌   63 ( 4 )   463 - 463   2021.6

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  • 甲状腺機能低下症とCKDの関連性におけるCr代謝の影響についての検討

    内山 奈津実, 辻 憲二, 喜多村 真治, 稲垣 兼一, 内田 治仁, 杉山 斉, 和田 淳

    日本腎臓学会誌   63 ( 4 )   463 - 463   2021.6

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  • 中四国地域におけるCKDおよびCVDの関連に関するコホート研究 Kakusyo 3C Studyのイベント解析

    大高 望, 内田 治仁, 竹内 英実, 辻 憲二, 田邊 克幸, 木野村 賢, 吉田 賢司, 前島 洋平, 杉山 斉, 伊藤 浩, 和田 淳

    日本腎臓学会誌   63 ( 4 )   464 - 464   2021.6

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  • 慢性腎臓病における貧血管理 Kakusyo 3C Studyからの検討

    奥山 由加, 内田 治仁, 大高 望, 竹内 英実, 辻 憲二, 田邊 克幸, 木野村 賢, 吉田 賢司, 前島 洋平, 杉山 斉, 伊藤 浩, 和田 淳

    日本腎臓学会誌   63 ( 4 )   474 - 474   2021.6

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  • 岡山市CKDネットワーク(OCKD-NET)におけるCKD病診連携10年後の追跡調査

    大西 康博, 内田 治仁, 大高 望, 竹内 英実, 辻 憲二, 田邊 克幸, 森永 裕士, 木野村 賢, 喜多村 真治, 前島 洋平, 杉山 斉, 太田 康介, 丸山 啓輔, 大城 義之, 森岡 茂, 瀧上 慶一, 蒲生 直幸, 和田 淳

    日本腎臓学会誌   63 ( 4 )   513 - 513   2021.6

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  • 両側乳頭浮腫を伴う肥厚性硬膜炎を発症した維持血液透析患者の一例

    内山 奈津実, 木野村 賢, 高橋 謙作, 谷村 智史, 森岡 朋代, 加納 弓月, 川北 智英子, 田邊 克幸, 内田 治仁, 杉山 斉, 難波 清人, 和田 淳

    中国腎不全研究会誌   29   27 - 28   2021.6

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  • Novel Urinary Glycan Biomarkers Predict Cardiovascular Events in Patients With Type 2 Diabetes: A Multicenter Prospective Study With 5-Year Follow Up (U-CARE Study 2) International journal

    Koki Mise, Mariko Imamura, Satoshi Yamaguchi, Mayu Watanabe, Chigusa Higuchi, Akihiro Katayama, Satoshi Miyamoto, Haruhito A. Uchida, Atsuko Nakatsuka, Jun Eguchi, Kazuyuki Hida, Tatsuaki Nakato, Atsuhito Tone, Sanae Teshigawara, Takashi Matsuoka, Shinji Kamei, Kazutoshi Murakami, Ikki Shimizu, Katsuhiro Miyashita, Shinichiro Ando, Tomokazu Nunoue, Michihiro Yoshida, Masao Yamada, Kenichi Shikata, Jun Wada

    Frontiers in Cardiovascular Medicine   8   668059 - 668059   2021.5

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    <bold>Background:</bold> Although various biomarkers predict cardiovascular event (CVE) in patients with diabetes, the relationship of urinary glycan profile with CVE in patients with diabetes remains unclear.

    <bold>Methods:</bold> Among 680 patients with type 2 diabetes, we examined the baseline urinary glycan signals binding to 45 lectins with different specificities. Primary outcome was defined as CVE including cardiovascular disease, stroke, and peripheral arterial disease.

    <bold>Results:</bold> During approximately a 5-year follow-up period, 62 patients reached the endpoint. Cox proportional hazards analysis revealed that urinary glycan signals binding to two lectins were significantly associated with the outcome after adjustment for known indicators of CVE and for false discovery rate, as well as increased model fitness. Hazard ratios for these lectins (+1 SD for the glycan index) were UDA (recognizing glycan: mixture of Man5 to Man9): 1.78 (95% CI: 1.24–2.55, <italic>P</italic> = 0.002) and Calsepa [High-Man (Man2–6)]: 1.56 (1.19–2.04, <italic>P</italic> = 0.001). Common glycan binding to these lectins was high-mannose type of <italic>N</italic>-glycans. Moreover, adding glycan index for UDA to a model including known confounders improved the outcome prediction [Difference of Harrel's C-index: 0.028 (95% CI: 0.001–0.055, <italic>P</italic> = 0.044), net reclassification improvement at 5-year risk increased by 0.368 (0.045–0.692, <italic>P</italic> = 0.026), and the Akaike information criterion and Bayesian information criterion decreased from 725.7 to 716.5, and 761.8 to 757.2, respectively].

    <bold>Conclusion:</bold> The urinary excretion of high-mannose glycan may be a valuable biomarker for improving prediction of CVE in patients with type 2 diabetes, and provides the rationale to explore the mechanism underlying abnormal <italic>N</italic>-glycosylation occurring in patients with diabetes at higher risk of CVE.

    <bold>Trial Registration:</bold> This study was registered with the University Hospital Medical Information Network on June 26, 2012 (Clinical trial number: UMIN000011525, URL: <ext-link>https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000013482</ext-link>).

    DOI: 10.3389/fcvm.2021.668059

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  • Vasohibin-2 Aggravates Development of Ascending Aortic Aneurysms but not Abdominal Aortic Aneurysms nor Atherosclerosis in ApoE-Deficient Mice. International journal

    Nozomu Otaka, Haruhito A Uchida, Michihiro Okuyama, Yoshiko Hada, Yasuhiro Onishi, Yuki Kakio, Hidemi Takeuchi, Ryoko Umebayashi, Katsuyuki Tanabe, Venkateswaran Subramanian, Alan Daugherty, Yasufumi Sato, Jun Wada

    American journal of hypertension   34 ( 5 )   467 - 475   2021.5

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    BACKGROUND: Vasohibin-2 (VASH2) has been isolated as a homologue of vasohibin-1 (VASH1) that promote angiogenesis counteracting with VASH1. Chronic angiotensin II (AngII) infusion promotes both ascending and abdominal aortic aneurysms (AAs) in mice. The present study aimed to investigate whether exogenous VASH2 influenced AngII-induced vascular pathology in apolipoprotein E deficient (ApoE  -/-) mice. METHODS: Male, ApoE  -/- mice (9 to 14 weeks old) were injected with Ad LacZ or Ad VASH2. After a week, saline or AngII (1,000 ng/kg/min) was infused into the mice subcutaneously via mini-osmotic pumps for 3 weeks. Consequently, all these mice were divided into 4 groups: saline + LacZ (n=5), saline + VASH2 (n=5), AngII + LacZ (n=18), and AngII + VASH2 (n=17). RESULTS: Exogenous VASH2 had no significant effect on ex vivo maximal diameters of abdominal aortas (AngII + LacZ; 1.67±0.17 mm, AngII + VASH2; 1.52±0.16 mm, n.s.) or elastin fragmentation and accumulation of inflammatory cells. Conversely, exogenous VASH2 significantly increased intima areas of aortic arches (AngII + LacZ; 16.6±0.27 mm 2, AngII + VASH2; 18.6±0.64 mm 2, p=0.006). VASH2 effect of AngII-induced ascending AAs was associated with increased cleaved caspase-3 abundance. AngII-induced atherosclerosis was not altered by VASH2. CONCLUSION: The present study demonstrated that augmented VASH2 expression had no effect of AngII-induced abdominal AAs or atherosclerosis, while increasing dilation in the ascending aorta.

    DOI: 10.1093/ajh/hpaa181

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  • Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice. International journal

    Latha Muniappan, Michihiro Okuyama, Aida Javidan, Devi Thiagarajan, Weihua Jiang, Jessica J Moorleghen, Lihua Yang, Anju Balakrishnan, Deborah A Howatt, Haruhito A Uchida, Takaomi C Saido, Venkateswaran Subramanian

    Arteriosclerosis, thrombosis, and vascular biology   41 ( 5 )   1694 - 1709   2021.5

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    [Figure: see text].

    DOI: 10.1161/ATVBAHA.120.315546

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  • 妊娠中に加温式リサキュレーション法を施行した家族性高コレステロール血症(ホモ接合体)の1例

    奥山 由加, 内田 治仁, 高橋 謙作, 藤原 千尋, 竹内 英実, 田邊 克幸, 木野村 賢, 和田 淳

    日本透析医学会雑誌   54 ( Suppl.1 )   360 - 360   2021.5

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  • Fisetin Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Macrophage. International journal

    Yoshiko Hada, Haruhito A Uchida, Jun Wada

    BioMed research international   2021   5570885 - 5570885   2021

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    Several studies have reported the efficacy and safety of polyphenols in human health; however, the verification of their efficacy remains insufficient. The aim of this study was to examine whether fisetin, one of flavonoids prevalently present in fruits and vegetables, could suppress lipopolysaccharide- (LPS-) induced inflammatory responses in macrophages. LPS increased proinflammatory mRNA abundance (MCP 1, IL-1β, and iNOS) but were suppressed by fisetin. The increment of nitric oxide by LPS, an oxidative stress factor, was attenuated by fisetin. In addition, LPS-enhanced phosphorylation of mitogen-activated protein kinase (ERK and JNK) was reduced. Finally, fisetin attenuated the expression or activity of uPA, uPAR, MMP-2, and MMP-9, which are known as associated factors of macrophage recruitment or infiltration. In conclusion, fisetin is a promising therapeutic agent for macrophage-related inflammation diseases, like sepsis and atherosclerosis.

    DOI: 10.1155/2021/5570885

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  • Inhibition of Interleukin-6 Signaling Attenuates Aortitis, Left Ventricular Hypertrophy and Arthritis in Interleukin-1 Receptor Antagonist Deficient Mice. Reviewed International journal

    Yoshiko Hada, Haruhito A Uchida, Tomoyuki Mukai, Fumiaki Kojima, Masashi Yoshida, Hidemi Takeuchi, Yuki Kakio, Nozomu Otaka, Yoshitaka Morita, Jun Wada

    Clinical science (London, England : 1979)   134 ( 20 )   2771 - 2787   2020.10

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    The aim of this study was to examine whether inhibition of Interleukin (IL)-6 signaling by MR16-1, an IL-6 receptor antibody, attenuates aortitis, cardiac hypertrophy, and arthritis in IL-1 receptor antagonist deficient (IL-1RA KO) mice.  Four weeks old mice were intraperitoneally administered with either MR16-1 or non-immune IgG at dosages that were adjusted over time for 5 weeks.  These mice were stratified into 4 groups: MR16-1 treatment groups, KO/MR low group (first 2.0 mg, following 0.5 mg/week, n=14) and KO/MR high group (first 4.0 mg, following 2.0 mg/week, n=19) in IL-1RA KO mice, and IgG treatment groups, KO/IgG group (first 2.0 mg, following 1.0 mg/week, n=22) in IL-1RA KO mice, and wild/IgG group (first 2.0 mg, following 1.0 mg/week, n=17) in wild mice.  Aortitis, cardiac hypertrophy and arthropathy were histologically analyzed.  Sixty-eight % of the KO/IgG group developed aortitis (53% developed severe aortitis).  In contrast, only 21% of the KO/MR high group developed mild aortitis, without severe aortitis (P<0.01, vs KO/IgG group).  Infiltration of inflammatory cells, such as neutrophils, T cells, and macrophages, was frequently observed around aortic sinus of the KO/IgG group.  Left ventricle and cardiomyocyte hypertrophy were observed in IL-1RA KO mice.  Administration of high dosage of MR16-1 significantly suppressed cardiomyocyte hypertrophy.  MR16-1 attenuated the incidence and severity of arthritis in IL-1RA KO mice in a dose-dependent manner.  In conclusion, blockade of IL-6 signaling may exert a beneficial effect to attenuate severe aortitis, left ventricle hypertrophy, and arthritis.

    DOI: 10.1042/CS20201036

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  • Low-dose rituximab induction therapy is effective in immunological high-risk renal transplantation without increasing cytomegalovirus infection. Reviewed International journal

    Kasumi Yoshinaga, Motoo Araki, Koichiro Wada, Yuki Maruyama, Yosuke Mitsui, Takuya Sadahira, Risa Kubota, Shingo Nishimura, Yasuyuki Kobayashi, Hidemi Takeuchi, Katsuyuki Tanabe, Masashi Kitagawa, Hiroshi Morinaga, Haruhito Adam Uchida, Shinji Kitamura, Hitoshi Sugiyama, Jun Wada, Masami Watanabe, Toyohiko Watanabe, Yasutomo Nasu

    International journal of urology : official journal of the Japanese Urological Association   27 ( 12 )   1136 - 1142   2020.10

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    OBJECTIVES: To analyze the effect and impact of low-dose rituximab induction therapy on cytomegalovirus infection in living-donor renal transplantation. METHODS: A total of 92 recipients undergoing living-donor renal transplantation at Okayama University Hospital from May 2009 to August 2018 were evaluated retrospectively. Indications for preoperative rituximab (200 mg/body) were the following: (i) ABO major mismatch; (ii) ABO minor mismatch; (iii) donor-specific anti-human leukocyte antigen antibody-positive; and (iv) focal segmental glomerulosclerosis. We excluded four recipients who were followed <3 months, five who received >200 mg/body rituximab and seven who received prophylactic therapy for cytomegalovirus. RESULTS: There were 59 patients in the rituximab group and 17 in the non-rituximab group. Groups differed significantly in age (median age 53 vs 37 years, respectively; P = 0.04), but not in sex (male 64% vs 65%, P = 1.00), focal segmental glomerulosclerosis (3% vs 0%, P = 1.00) or percentage of cytomegalovirus-seronegative recipients of renal allografts from cytomegalovirus-seropositive donors (12% vs 18%, P = 0.68). The estimated glomerular filtration rate did not differ significantly between groups until 24 months after transplantation. Cytomegalovirus clinical symptoms (10% vs 24%, P = 0.22), including fever ≥38°C (5% vs 12%, P = 0.31) and gastrointestinal symptoms (5% vs 12%, P = 0.31), and the 5-year survival rates of death-censored graft loss (90% vs 83%, P = 0.43) did not differ significantly between groups. CONCLUSIONS: Low-dose rituximab induction therapy is effective in immunological high-risk recipients without increasing cytomegalovirus infection in the absence of valganciclovir prophylaxis.

    DOI: 10.1111/iju.14382

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  • 腎不全療法選択説明が緊急透析導入と療法選択に与える影響

    森永 裕士, 笠原 由美子, 井本 紀子, 角川 紫野, 矢田 光子, 大高 望, 辻 憲二, 北川 正史, 田邊 克幸, 木野村 賢, 喜多村 真治, 内田 治仁, 杉山 斉, 和田 淳

    日本透析医学会雑誌   53 ( Suppl.1 )   496 - 496   2020.10

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  • PAD合併により著明に増悪したフレイルな透析患者の予後

    竹内 英実, 内田 治仁, 大高 望, 梅林 亮子, 杉山 斉, 和田 淳

    日本透析医学会雑誌   53 ( Suppl.1 )   736 - 736   2020.10

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  • 内シャント再設置術の成績・術式・リスク因子の検討

    藤井 泰宏, 大澤 晋, 内田 治仁, 竹内 英実, 大高 望, 笠原 真悟

    脈管学   60 ( Suppl. )   S161 - S161   2020.10

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  • 末梢動脈疾患が動脈スティフネスパラメータに与える影響の検討

    武本 梨佳, 内田 治仁, 戸田 洋伸, 大塚 文男, 伊藤 浩, 和田 淳

    脈管学   60 ( Suppl. )   S172 - S172   2020.10

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  • Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis. Reviewed International journal

    Ichiro Nojima, Shingo Eikawa, Nahoko Tomonobu, Yoshiko Hada, Nobuo Kajitani, Sanae Teshigawara, Satoshi Miyamoto, Atsuhito Tone, Haruhito A Uchida, Atsuko Nakatsuka, Jun Eguchi, Kenichi Shikata, Heiichiro Udono, Jun Wada

    Scientific reports   10 ( 1 )   14928 - 14928   2020.9

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    The metabolic changes and dysfunction in CD8 + T cells may be involved in tumor progression and susceptibility to virus infection in type 2 diabetes (T2D). In C57BL/6JJcl mice fed with high fat-high sucrose chow (HFS), multifunctionality of CD8 + splenic and tumor-infiltrating lymphocytes (TILs) was impaired and associated with enhanced tumor growth, which were inhibited by metformin. In CD8 + splenic T cells from the HFS mice, glycolysis/basal respiration ratio was significantly reduced and reversed by metformin. In the patients with T2D (DM), multifunctionality of circulating CD8 + PD-1 + T cells stimulated with PMA/ionomycin as well as with HLA-A*24:02 CMV peptide was dampened, while metformin recovered multifunctionality. Both glycolysis and basal respiration were reduced in DM, and glycolysis was increased by metformin. The disturbance of the link between metabolism and immune function in CD8 + PD-1 + T cells in T2D was proved by recovery of antigen-specific and non-specific cytokine production via metformin-mediated increase in glycolytic activity.

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  • Tubulointerstitial Nephritis Cases With IgM-Positive Plasma Cells. Reviewed International journal

    Natsumi Matsuoka-Uchiyama, Kenji Tsuji, Kazuhiko Fukushima, Shinji Kitamura, Haruhito A Uchida, Hitoshi Sugiyama, Naoki Takahashi, Masayuki Iwano, Jun Wada

    Kidney international reports   5 ( 9 )   1576 - 1580   2020.9

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  • 2型糖尿病に対するメトホルミンの抗腫瘍効果

    野島 一郎, 榮川 伸吾, 梶谷 展生, 勅使川原 早苗, 宮本 聡, 利根 淳仁, 内田 治仁, 中司 敦子, 江口 潤, 四方 賢一, 鵜殿 平一郎, 和田 淳

    糖尿病   63 ( Suppl.1 )   S - 111   2020.8

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  • 中四国地域におけるCKDおよびCVDの関連に関するコホート研究Kakusyo 3C Study:登録3年後のCKD管理状況

    西脇 麻里子, 内田 治仁, 大高 望, 辻 憲二, 北川 正史, 田邊 克幸, 木野村 賢, 吉田 賢司, 前島 洋平, 杉山 斉, 伊藤 浩, 和田 淳

    日本腎臓学会誌   62 ( 4 )   378 - 378   2020.7

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  • 慢性腎臓病における貧血管理〜Kakusyo 3C Studyからの検討

    内山 奈津実, 内田 治仁, 西脇 麻里子, 大高 望, 辻 憲二, 北川 正史, 田邊 克幸, 木野村 賢, 吉田 賢司, 前島 洋平, 杉山 斉, 伊藤 浩, 和田 淳

    日本腎臓学会誌   62 ( 4 )   378 - 378   2020.7

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  • 岡山市CKDネットワーク(OCKD-NET)におけるCKD病診連携9年後の追跡調査

    大西 康博, 内田 治仁, 大高 望, 辻 憲二, 田邊 克幸, 森永 裕士, 木野村 賢, 喜多村 真治, 前島 洋平, 杉山 斉, 太田 康介, 丸山 啓輔, 大城 義之, 森岡 茂, 大森 一慶, 瀧上 慶一, 蒲生 直幸, 和田 淳

    日本腎臓学会誌   62 ( 4 )   307 - 307   2020.7

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  • The Protective Effect of Chlorogenic Acid on Vascular Senescence via the Nrf2/HO-1 Pathway. Reviewed International journal

    Yoshiko Hada, Haruhito A Uchida, Nozomu Otaka, Yasuhiro Onishi, Shugo Okamoto, Mariko Nishiwaki, Rika Takemoto, Hidemi Takeuchi, Jun Wada

    International journal of molecular sciences   21 ( 12 )   2020.6

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    The world faces the serious problem of aging. In this study, we aimed to investigate the effect of chlorogenic acid (CGA) on vascular senescence. C57/BL6 female mice that were 14 ± 3 months old were infused with either Angiotensin II (AngII) or saline subcutaneously for two weeks. These mice were administered CGA of 20 or 40 mg/kg/day, or saline via oral gavage. AngII infusion developed vascular senescence, which was confirmed by senescence associated-β-galactosidase (SA-β-gal) staining. CGA administration attenuated vascular senescence in a dose-dependent manner, in association with the increase of Sirtuin 1 (Sirt1) and endothelial nitric oxide synthase (eNOS), and with the decrease of p-Akt, PAI-1, p53, and p21. In an in vitro study, with or without pre-treatment of CGA, Human Umbilical Vein Endothelial Cells (HUVECs) were stimulated with H2O2 for an hour, then cultured in the absence or presence of 0.5-5.0 μM CGA for the indicated time. Endothelial cell senescence was induced by H2O2, which was attenuated by CGA treatment. Pre-treatment of CGA increased Nrf2 in HUVECs. After H2O2 treatment, translocation of Nrf2 into the nucleus and the subsequent increase of Heme Oxygenase-1 (HO-1) were observed earlier in CGA-treated cells. Furthermore, the HO-1 inhibitor canceled the beneficial effect of CGA on vascular senescence in mice. In conclusion, CGA exerts a beneficial effect on vascular senescence, which is at least partly dependent on the Nuclear factor erythroid 2-factor 2 (Nrf2)/HO-1 pathway.

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  • Effect of Angiotensin II on Bone Erosion and Systemic Bone Loss in Mice with Tumor Necrosis Factor-Mediated Arthritis. Reviewed International journal

    Takahiko Akagi, Tomoyuki Mukai, Takafumi Mito, Kyoko Kawahara, Shoko Tsuji, Shunichi Fujita, Haruhito A Uchida, Yoshitaka Morita

    International journal of molecular sciences   21 ( 11 )   2020.6

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    Angiotensin II (Ang II) is the main effector peptide of the renin-angiotensin system (RAS), which regulates the cardiovascular system. The RAS is reportedly also involved in bone metabolism. The upregulation of RAS components has been shown in arthritic synovial tissues, suggesting the potential involvement of Ang II in arthritis. Accordingly, in the present study, we investigated the role of Ang II in bone erosion and systemic bone loss in arthritis. Ang II was infused by osmotic pumps in tumor necrosis factor-transgenic (TNFtg) mice. Ang II infusion did not significantly affect the severity of clinical and histological inflammation, whereas bone erosion in the inflamed joints was significantly augmented. Ang II administration did not affect the bone mass of the tibia or vertebra. To suppress endogenous Ang II, Ang II type 1 receptor (AT1R)-deficient mice were crossed with TNFtg mice. Genetic deletion of AT1R did not significantly affect inflammation, bone erosion, or systemic bone loss. These results suggest that excessive systemic activation of the RAS can be a risk factor for progressive joint destruction. Our findings indicate an important implication for the pathogenesis of inflammatory bone destruction and for the clinical use of RAS inhibitors in patients with rheumatoid arthritis.

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  • Frailty Raises as a New Target in Patients with Chronic Hemodialysis in any Country and the Problem we Should Solve Reviewed

    Hidemi Takeuchi, Haruhito A Uchida, Jun Wada

    Journal of Clinical Trials   10 ( 3 )   2020.6

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  • Targeting Mitochondrial Fission as a Potential Therapeutic for Abdominal Aortic Aneurysm. Reviewed International journal

    Hannah A Cooper, Stephanie Cicalese, Kyle J Preston, Tatsuo Kawai, Keisuke Okuno, Eric T Choi, Shingo Kasahara, Haruhito A Uchida, Nozomu Otaka, Rosario Scalia, Victor Rizzo, Satoru Eguchi

    Cardiovascular research   117 ( 3 )   971 - 982   2020.5

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    AIMS: Angiotensin II is a potential contributor to the development of abdominal aortic aneurysm (AAA). In aortic vascular smooth muscle cells, exposure to angiotensin II induces mitochondrial fission via dynamin-related protein 1 (Drp1). However, pathophysiological relevance of mitochondrial morphology in angiotensin II-associated AAA remains unexplored. Here, we tested the hypothesis that mitochondrial fission is involved in the development of AAA. METHODS AND RESULTS: Immunohistochemistry was performed on human AAA samples and revealed enhanced expression of Drp1. In C57BL6 mice treated with angiotensin II plus β-aminopropionitrile, AAA tissue also showed an increase in Drp1 expression. A mitochondrial fission inhibitor, mdivi1, attenuated AAA size, associated aortic pathology, Drp1 protein induction and mitochondrial fission but not hypertension in these mice. Moreover, Western blot analysis showed that induction of matrix metalloproteinase-2, which precedes the development of AAA, was blocked by mdivi1. Mdivi1 also reduced the development of AAA in apolipoprotein E deficient mice infused with angiotensin II. As with mdivi1, Drp1+/- mice treated with angiotensin II plus β-aminopropionitrile showed a decrease in AAA compared to control Drp1+/+ mice. In abdominal aortic vascular smooth muscle cells, angiotensin II induced phosphorylation of Drp1 and mitochondrial fission, the latter of which was attenuated with Drp1 silencing as well as mdivi1. Angiotensin II also induced vascular cell adhesion molecule-1 expression and enhanced leukocyte adhesion and mitochondrial oxygen consumption in smooth muscle cells, which were attenuated with mdivi1. CONCLUSION: These data indicate that Drp1 and mitochondrial fission play salient roles in AAA development, which likely involves mitochondrial dysfunction and inflammatory activation of vascular smooth muscle cells. TRANSLATIONAL PERSPECTIVES: Mitochondrial fission/fusion regulation is critical to maintain mitochondrial homeostasis. A shift toward mitochondrial fission is associated with a variety of cardiovascular diseases. A GTPase, Drp1 is known to mediate mitochondrial fission and we found evidence of Drp1 dysregulation in human and mouse abdominal aortic aneurysms (AAA). The results from the present study demonstrate that pharmacological as well as genetic inhibition of mitochondrial fission via Drp1 prevents AAA formation and vascular smooth muscle aneurysmal phenotype in mouse models of the disease. These data indicate that intervening in this pathway may have therapeutic potential for treating AAA.

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  • Associated factors of poor treatment outcomes in patients with giant cell arteritis: clinical implication of large vessel lesions. Reviewed International journal

    Takahiko Sugihara, Hitoshi Hasegawa, Haruhito A Uchida, Hajime Yoshifuji, Yoshiko Watanabe, Eisuke Amiya, Yasuhiro Maejima, Masanori Konishi, Yohko Murakawa, Noriyoshi Ogawa, Shunsuke Furuta, Yasuhiro Katsumata, Yoshinori Komagata, Taio Naniwa, Takahiro Okazaki, Yoshiya Tanaka, Tsutomu Takeuchi, Yoshikazu Nakaoka, Yoshihiro Arimura, Masayoshi Harigai, Mitsuaki Isobe

    Arthritis research & therapy   22 ( 1 )   72 - 72   2020.4

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    BACKGROUND: Relapses frequently occur in giant cell arteritis (GCA), and long-term glucocorticoid therapy is required. The identification of associated factors with poor treatment outcomes is important to decide the treatment algorithm of GCA. METHODS: We enrolled 139 newly diagnosed GCA patients treated with glucocorticoids between 2007 and 2014 in a retrospective, multi-center registry. Patients were diagnosed with temporal artery biopsy, 1990 American College of Rheumatology classification criteria, or large vessel lesions (LVLs) detected by imaging based on the modified classification criteria. Poor treatment outcomes (non-achievement of clinical remission by week 24 or relapse during 52 weeks) were evaluated. Clinical remission was defined as the absence of clinical signs and symptoms in cranial and large vessel areas, polymyalgia rheumatica (PMR), and elevation of C-reactive protein (CRP) levels. A patient was determined to have a relapse if he/she had either one of the signs and symptoms that newly appeared or worsened after achieving clinical remission. Re-elevation of CRP without clinical manifestations was considered as a relapse if other causes such as infection were excluded and the treatment was intensified. Associated factors with poor treatment outcomes were analyzed by using the Cox proportional hazard model. RESULTS: Cranial lesions, PMR, and LVLs were detected in 77.7%, 41.7%, and 52.5% of the enrolled patients, respectively. Treatment outcomes were evaluated in 119 newly diagnosed patients who were observed for 24 weeks or longer. The mean initial dose of prednisolone was 0.76 mg/kg/day, and 29.4% received any concomitant immunosuppressive drugs at baseline. Overall, 41 (34.5%) of the 119 patients had poor treatment outcomes; 13 did not achieve clinical remission by week 24, and 28 had a relapse after achieving clinical remission. Cumulative rates of the events of poor treatment outcomes in patients with and without LVLs were 47.5% and 17.7%, respectively. A multivariable model showed the presence of LVLs at baseline was significantly associated with poor treatment outcomes (adjusted hazard ratio [HR] 3.54, 95% CI 1.52-8.24, p = 0.003). Cranial lesions and PMR did not increase the risk of poor treatment outcomes. CONCLUSION: The initial treatment intensity in the treatment algorithm of GCA could be determined based upon the presence or absence of LVLs detected by imaging at baseline.

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  • JCS 2017 Guideline on Management of Vasculitis Syndrome - Digest Version. Reviewed

    Mitsuaki Isobe, Koichi Amano, Yoshihiro Arimura, Akihiro Ishizu, Shuichi Ito, Shinya Kaname, Shigeto Kobayashi, Yoshinori Komagata, Issei Komuro, Kimihiro Komori, Kei Takahashi, Kazuo Tanemoto, Hitoshi Hasegawa, Masayoshi Harigai, Shouichi Fujimoto, Tatsuhiko Miyazaki, Tetsuro Miyata, Hidehiro Yamada, Akitoshi Yoshida, Takashi Wada, Yoshinori Inoue, Haruhito A Uchida, Hideki Ota, Takahiro Okazaki, Mitsuho Onimaru, Tamihiro Kawakami, Reiko Kinouchi, Atsushi Kurata, Hisanori Kosuge, Ken-Ei Sada, Kunihiro Shigematsu, Eiichi Suematsu, Eijun Sueyoshi, Takahiko Sugihara, Hitoshi Sugiyama, Mitsuhiro Takeno, Naoto Tamura, Michi Tsutsumino, Hiroaki Dobashi, Yoshikazu Nakaoka, Kenji Nagasaka, Yasuhiro Maejima, Hajime Yoshifuji, Yoshiko Watanabe, Shoichi Ozaki, Takeshi Kimura, Hiroshi Shigematsu, Keiko Yamauchi-Takihara, Toyoaki Murohara, Shin-Ichi Momomura

    Circulation journal : official journal of the Japanese Circulation Society   84 ( 2 )   299 - 359   2020.1

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    DOI: 10.1253/circj.CJ-19-0773

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  • Podocyte autophagy is associated with foot process effacement and proteinuria in patients with minimal change nephrotic syndrome. Reviewed International journal

    Ayu Ogawa-Akiyama, Hitoshi Sugiyama, Masashi Kitagawa, Keiko Tanaka, Yuzuki Kano, Koki Mise, Nozomu Otaka, Katsuyuki Tanabe, Hiroshi Morinaga, Masaru Kinomura, Haruhito A Uchida, Jun Wada

    PloS one   15 ( 1 )   e0228337   2020

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    Autophagy is a cellular mechanism involved in the bulk degradation of proteins and turnover of organelle. Several studies have shown the significance of autophagy of the renal tubular epithelium in rodent models of tubulointerstitial disorder. However, the role of autophagy in the regulation of human glomerular diseases is largely unknown. The current study aimed to demonstrate morphological evidence of autophagy and its association with the ultrastructural changes of podocytes and clinical data in patients with idiopathic nephrotic syndrome, a disease in which patients exhibit podocyte injury. The study population included 95 patients, including patients with glomerular disease (minimal change nephrotic syndrome [MCNS], n = 41; idiopathic membranous nephropathy [IMN], n = 37) and 17 control subjects who underwent percutaneous renal biopsy. The number of autophagic vacuoles and the grade of foot process effacement (FPE) in podocytes were examined by electron microscopy (EM). The relationships among the expression of autophagic vacuoles, the grade of FPE, and the clinical data were determined. Autophagic vacuoles were mainly detected in podocytes by EM. The microtubule-associated protein 1 light chain 3 (LC3)-positive area was co-localized with the Wilms tumor 1 (WT1)-positive area on immunofluorescence microscopy, which suggested that autophagy occurred in the podocytes of patients with MCNS. The number of autophagic vacuoles in the podocytes was significantly correlated with the podocyte FPE score (r = -0.443, p = 0.004), the amount of proteinuria (r = 0.334, p = 0.033), and the level of serum albumin (r = -0.317, p = 0.043) in patients with MCNS. The FPE score was a significant determinant for autophagy after adjusting for the age in a multiple regression analysis in MCNS patients (p = 0.0456). However, such correlations were not observed in patients with IMN or in control subjects. In conclusion, the results indicated that the autophagy of podocytes is associated with FPE and severe proteinuria in patients with MCNS. The mechanisms underlying the activation of autophagy in association with FPE in podocytes should be further investigated in order to elucidate the pathophysiology of MCNS.

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  • The Aging Population and Research into Treatments for Abdominal Aortic Aneurysms. Reviewed

    Ryoko Umebayashi, Haruhito Adam Uchida, Jun Wada

    Acta medica Okayama   73 ( 6 )   475 - 477   2019.12

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    Abdominal aortic aneurysms (AAAs) usually expand asymptomatically until the occurrence of a life-threatening event such as aortic rupture, which is closely associated with high mortality. AAA and aortic dissection are ranked among the top 10 causes of death in Japan. The major risk factors for AAA are age over 65 years, male gender, family history, and smoking. Thus, for prevention, smoking cessation is the most important lifestyle-intervention. For treatment, since AAA generally affects elderly people, less invasive treatment is preferable. However, the only established treatment for AAA is open repair and endovascular repair. This review describes potential medical treatments to slow aneurysm growth or prevent AAA rupture.

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  • 18歳時に経皮的腎動脈形成術を行い10年以上経過して血圧上昇をきたした高安動脈炎の1例

    内田 治仁, 戸田 洋伸, 藤本 竜一, 大塚 寛昭, 花山 宜久, 武本 梨佳, 大西 康博, 高杉 佳奈子, 梅林 亮子, 吉田 賢司, 和田 淳

    脈管学   59 ( Suppl. )   S226 - S226   2019.10

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  • PAD患者におけるTotal Vascular ResistanceおよびAugmentation Pressureに関する検討

    内田 治仁, 武本 梨佳, 松岡 奈津美, 大西 康博, 岡本 修吾, 西脇 麻里子, 秦 昌紫子, 大高 望, 戸田 洋伸, 北川 正史, 和田 淳

    日本高血圧学会総会プログラム・抄録集   42回   348 - 348   2019.10

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  • フェブキソスタットによる尿酸低下が血管機能に与える影響の検討

    松岡 奈津実, 内田 治仁, 前島 洋平, 雛元 紀和, 浅野 健一郎, 大西 康博, 岡本 修吾, 西脇 麻里子, 秦 昌紫子, 武本 梨佳, 大高 望, 北川 正史, 和田 淳

    日本高血圧学会総会プログラム・抄録集   42回   368 - 368   2019.10

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  • Impaired mental health status in patients with chronic kidney disease is associated with estimated glomerular filtration rate decline. Reviewed International journal

    Yasuhiro Onishi, Haruhito A Uchida, Hidemi Takeuchi, Yuki Kakio, Hitoshi Sugiyama, Jun Wada, Noriaki Shimada, Hironobu Tokumasu, Masaki Fukushima, Kenichiro Asano

    Nephrology (Carlton, Vic.)   24 ( 9 )   926 - 932   2019.9

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    AIM: Deteriorated health-related quality of life (HRQOL) is associated with increased risk for death in both chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients; however, the impact of HRQOL on CKD progression is not well investigated. METHODS: We aimed to evaluate the association between HRQOL and CKD progression in Japanese patients with CKD. One hundred and three outpatients who visited the department of nephrology at our hospital (mean estimated glomerular filtration rate (eGFR); 32.1 ± 11.2 mL/min per 1.73 m2 ) between April 2007 and March 2012 were enrolled in this study. The primary outcome was 30% decline of eGFR or ESRD. We assessed HRQOL of all participants at baseline, including the physical component summary (PCS), the mental component summary (MCS) and the role/social component summary (RCS), using SF-36. Based on the baseline score of PCS, MCS and RCS, we divided all subjects into two groups by median. RESULTS: We studied 66 men (64.1%) and 37 women aged 61.7 ± 10.0 years old. During approximately 2.5 years of follow-up period, 59 patients (57.3%) reached 30% eGFR decline or ESRD. Cox regression analyses demonstrated that lower MCS score was significantly associated with CKD progression (hazard ratio (HR) = 1.83, 95% CI = 1.04-3.21, P = 0.035), but that lower PCS score and RCS score were not (HR = 0.70, 95% CI = 0.39-1.25, P = 0.223; HR = 0.95, 95% CI = 0.54-1.67, P = 0.854, respectively). CONCLUSION: We found that impaired mental health was associated with CKD progression. The evaluation of the mental health should be performed in the patients with CKD.

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  • A Patient with Type 3 Autoimmune Polyglandular Syndrome who Developed Systemic Lupus Erythematosus 8 years after the Diagnosis of Autoimmune Hepatitis. Reviewed

    Tomoyo Mifune-Morioka, Haruhito A Uchida, Kazuhiko Fukushima, Mayu Watanabe, Chihiro Ouchi, Koki Mise, Chieko Kawakita, Yuzuki Kano, Akifumi Onishi, Kishio Toma, Jun Eguchi, Nozomu Wada, Fusao Ikeda, Erika Sasaki, Yu Suganami, Masayuki Kishida, Hitoshi Sugiyama, Hiroyuki Okada, Jun Wada

    Acta medica Okayama   73 ( 4 )   367 - 372   2019.8

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    Eight years prior to her present admission, a 61-year-old Japanese woman was diagnosed with autoimmune hepatitis, slowly progressive insulin-dependent diabetes mellitus, and chronic thyroiditis; she had been treated with oral prednisolone (PSL). After she suddenly discontinued PSL, she newly developed systemic lupus erythematosus. A combination therapy of oral PSL and intravenous cyclophosphamide resulted in remission. She was finally diagnosed with autoimmune polyglandular syndrome (APS) type 3 (3A ,3B, 3D), complicated with four different autoimmune diseases. Since patients with type 3 APS may present many manifestations over a long period of time, they should be carefully monitored.

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  • Combination of Renal Angioplasty and Angiotensin-converting-enzyme Inhibitor Can Reduce Proteinuria in Patients with Bilateral Renal Artery Disease. Reviewed

    Hironobu Toda, Haruhito Uchida, Kazufumi Nakamura, Hidemi Takeuchi, Masaru Kinomura, Koji Nakagawa, Atsuyuki Watanabe, Toru Miyoshi, Nobuhiro Nishii, Hiroshi Morita, Jun Wada, Hiroshi Ito

    Internal medicine (Tokyo, Japan)   58 ( 13 )   1917 - 1922   2019.7

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    Recent large clinical trials failed to show clear benefits of percutaneous transluminal renal angioplasty (PTRA) as compared with medical therapy on patients with renal artery stenosis. It was also reported that proteinuria is an adverse prognostic factor after PTRA, and PTRA is less effective in patients with overt proteinuria. From the renoprotective point of view, to reduce proteinuria after PTRA is an important therapeutic goal in patients with renal artery stenosis with overt proteinuria. We hereby describe two patients successfully treated by combination therapy with PTRA and administration of angiotensin-converting enzyme (ACE) inhibitor for bilateral renal artery disease with overt proteinuria.

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  • 血管内皮細胞における細胞老化に対するクロロゲン酸の及ぼす影響の検討

    秦 昌紫子, 内田 治仁, 大高 望, 大西 康博, 和田 淳

    日本動脈硬化学会総会プログラム・抄録集   51回   1 - 5   2019.7

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  • Osteomalacia and Fanconi Syndrome Induced by Adefovir. Reviewed

    Natsumi Matsuoka, Haruhito A Uchida, Yoshikazu Hara, Hiroto Matsuda

    Internal medicine (Tokyo, Japan)   58 ( 11 )   1659 - 1659   2019.6

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  • The clinical efficacy of angiotensin II type1 receptor blockers on inflammatory markers in patients with hypertension: a multicenter randomized-controlled trial; MUSCAT-3 study. Reviewed International journal

    Ryoko Umebayashi, Haruhito A Uchida, Yuka Okuyama, Yuki Kakio, Yoshihisa Hanayama, Kenichi Shikata, Jun Wada

    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals   24 ( 3 )   255 - 261   2019.5

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    Purpose: The purpose of present study was to evaluate the clinical efficacy of irbesartan on the anti-inflammatory and anti-oxidative stress effect in patients with hypertension compared to other ARBs. Further, we assessed the effect of the ARBs on kidney function and urinary albumin excretion. Methods: Eighty-five outpatients with hypertension who took an ARB except irbesartan more than 3 months were assigned into two groups, one continued the same ARB and the other switched the ARB to irbesartan for 6 months. Results: Although blood pressures were equally controlled (continue group: 148 ± 2/79 ± 2 mmHg to 131 ± 2/74 ± 2 mmHg; switch group: 152 ± 2/81 ± 2 mmHg to 132 ± 2/74 ± 2 mmHg; p < 0.001 each), the inflammatory markers (hsCRP, PTX3, MCP-1) and oxidative stress marker (MDA-LDL) did not change after 6 months in both groups. Urinary albumin excretion was significantly reduced only in the switch group without renal function deterioration (switch group 292.4 ± 857.9 mg/gCr to 250.6 ± 906.5 mg/gCr, p = 0.012). Conclusion: These results provide knowledge of the characteristics of irbesartan, suggesting appropriate choice of ARBs in the treatment for hypertension should be considered.

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  • 当院で腹膜透析を導入した多発性嚢胞腎患者に関する検討

    大西 康博, 田邊 克幸, 大高 望, 大西 章史, 北川 正史, 森永 裕士, 木野村 賢, 内田 治仁, 杉山 斉, 和田 淳

    日本透析医学会雑誌   52 ( Suppl.1 )   549 - 549   2019.5

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  • 岡山市CKDネットワーク(OCKD-NET)におけるCKD病診連携8年後の追跡調査

    大西 康博, 内田 治仁, 大高 望, 田邊 克幸, 森永 裕士, 木野村 賢, 前島 洋平, 杉山 斉, 太田 康介, 丸山 啓輔, 平松 信, 大城 義之, 森岡 茂, 福島 正樹, 和田 淳

    日本腎臓学会誌   61 ( 3 )   388 - 388   2019.5

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  • Higher Serum Testosterone Levels Associated with Favorable Prognosis in Enzalutamide- and Abiraterone-Treated Castration-Resistant Prostate Cancer. Reviewed International journal

    Shinichi Sakamoto, Maihulan Maimaiti, Minhui Xu, Shuhei Kamada, Yasutaka Yamada, Hiroki Kitoh, Hiroaki Matsumoto, Nobuyoshi Takeuchi, Kosuke Higuchi, Haruhito A Uchida, Akira Komiya, Maki Nagata, Hiroomi Nakatsu, Hideyasu Matsuyama, Koichiro Akakura, Tomohiko Ichikawa

    Journal of clinical medicine   8 ( 4 )   2019.4

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    Testosterone plays a significant role in maintaining the tumor microenvironment. The role of the target serum testosterone (TST) level in enzalutamide- (Enza) and abiraterone (Abi)-treated castration-resistant prostate cancer (CRPC) patients was studied. In total, 107 patients treated with Enza and/or Abi at Chiba University Hospital and affiliated hospitals were studied. The relationships between progression-free survival (PFS), overall survival (OS), and clinical factors were studied by Cox proportional hazard and Kaplan-Meier models. In the Abi and Enza groups overall, TST ≥ 13 ng/dL (median) (Hazard Ratio (HR) 0.43, p = 0.0032) remained an independent prognostic factor for PFS. In the Enza group, TST ≥ 13 ng/dL (median) was found to be a significant prognostic factor (HR 0.28, p = 0.0044), while, in the Abi group, TST ≥ 12 ng/dL (median) was not significant (HR 0.40, p = 0.0891). TST showed significant correlation with PFS periods (r = 0. 32, p = 0.0067), whereas, for OS, TST ≥ 13 ng/dL (median) showed no significant difference in the Abi and Enza groups overall. According to Kaplan-Meier analysis, a longer PFS at first-line therapy showed a favorable prognosis in the Enza group (p = 0.0429), while no difference was observed in the Abi group (p = 0.6051). The TST level and PFS of first-line therapy may be considered when determining the treatment strategy for CRPC patients.

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  • Exogenous Vasohibin-2 Exacerbates Angiotensin II-Induced Ascending Aortic Dilation in Mice. Reviewed

    Michihiro Okuyama, Haruhito A Uchida, Yoshiko Hada, Yuki Kakio, Nozomu Otaka, Ryoko Umebayashi, Katsuyuki Tanabe, Yasuhiro Fujii, Shingo Kasahara, Venkateswaran Subramanian, Alan Daugherty, Yasufumi Sato, Jun Wada

    Circulation reports   1 ( 4 )   155 - 161   2019.4

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    Background: Chronic angiotensin II (AngII) infusion promotes ascending aortic dilation in C57BL/6J mice. Meanwhile, vasohibin-2 (VASH2) is an angiogenesis promoter in neovascularization under various pathologic conditions. The aim of this study was to investigate whether exogenous VASH2 influences chronic AngII-induced ascending aortic dilation. Methods and Results: Eight-ten-week-old male C57BL/6J mice were injected with adenovirus (Ad) expressing either VASH2 or LacZ. One week after the injection, mice were infused with either AngII or saline s.c. for 3 weeks. Mice were divided into 4 groups: AngII+VASH2, AngII+LacZ, saline+VASH2, and saline+LacZ. Overexpression of VASH2 significantly increased AngII-induced intimal areas as well as the external diameter of the ascending aorta. In addition, VASH2 overexpression promoted ascending aortic medial elastin fragmentation in AngII-infused mice, which was associated with increased matrix metalloproteinase activity and medial smooth muscle cell (SMC) apoptosis. On western blot analysis, accumulation of apoptotic signaling proteins, p21 and p53 was increased in the AngII+VASH2 group. Furthermore, transfection of human aortic SMC with Ad VASH2 increased p21 and p53 protein abundance upon AngII stimulation. Positive TUNEL staining was also detected in the same group of the human aortic SMC. Conclusions: Exogenous VASH2 exacerbates AngII-induced ascending aortic dilation in vivo, which is associated with increased medial apoptosis and elastin fragmentation.

    DOI: 10.1253/circrep.CR-19-0008

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  • The relationship between repeated measurement of casual and 24-h urinary sodium-to-potassium ratio in patients with chronic kidney disease. Reviewed International journal

    Yuka Okuyama, Haruhito A Uchida, Toshiyuki Iwahori, Hiroyoshi Segawa, Ayako Kato, Hidemi Takeuchi, Yuki Kakio, Ryoko Umebayashi, Masashi Kitagawa, Hitoshi Sugiyama, Katsuyuki Miura, Hirotsugu Ueshima, Jun Wada

    Journal of human hypertension   33 ( 4 )   286 - 297   2019.4

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    This study aimed to clarify the relationship between repeated measurements of casual (spot) and 24-h urinary sodium-to-potassium (Na/K) ratios in patients with chronic kidney disease (CKD). A total of 61 inpatients with CKD, 31 in stage 1-3 (eGFR [estimated glomerular filtration rate] ≥ 30 ml/min/1.73 m2) and 30 in stage 4-5 (eGFR < 30 ml/min/1.73 m2), aged 20-85 consuming a low-sodium diet (NaCl [sodium chloride] 6 g/day) were recruited. Urinary Na, K, and Na/K ratios were measured in both casual urine samples and 2-day, 24 h urine samples, and then analyzed by correlation and Bland-Altman analyses. Mean 24-h urine Na/K ratio was higher in participants in stage 4-5 (5.1) than in participants in stage 1-3 (4.1) CKD. Casual urine Na/K ratio was strongly correlated with 2-day, 24-h urine Na/K ratio by sampling 4 casual urine specimens every morning and evening in participants in stage 1-3 (r = 0.69-0.78), but not in stage 4-5 (r = 0.12-0.19). The bias for mean Na/K ratio between 2-day, 24-h urine, and the 4 casual urine sampling ranged from -0.86 to 0.16 in participants in stage 1-3, and the quality of agreement for the mean of this casual urine sampling was similar to that of sampling 8 casual urine samples for estimating 2-day, 24-h values. Methods using repeated casual urine Na/K ratios may provide a reasonable estimation of 24-h urine Na/K ratio in normotensive and hypertensive as well as individuals with stage 1-3, but not stage 4-5 CKD.

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  • Urine 5MedC, a Marker of DNA Methylation, in the Progression of Chronic Kidney Disease. Reviewed International journal

    Akifumi Onishi, Hitoshi Sugiyama, Masashi Kitagawa, Toshio Yamanari, Keiko Tanaka, Ayu Ogawa-Akiyama, Yuzuki Kano, Koki Mise, Katsuyuki Tanabe, Hiroshi Morinaga, Masaru Kinomura, Haruhito A Uchida, Jun Wada

    Disease markers   2019   5432453 - 5432453   2019

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    Background: Alterations in DNA methylation may be involved in disease progression in patients with chronic kidney disease (CKD). Recent studies have suggested that 5-methyl-2'-deoxycytidine (5MedC) may be a marker of hypermethylation of DNA. Currently, there is no information available regarding the urine levels of 5MedC and its association with the progression of CKD. Method: We examined the urine levels of 5MedC in spot urine samples from 308 patients with CKD (median age: 56 years, male: 53.2%, and glomerulonephritis: 51.0%) using a competitive enzyme-linked immunosorbent assay and investigated the relationships among urine 5MedC, urine albumin, urine α1-microglobulin (α1MG), and the laboratory parameters associated with CKD. The patients were followed for three years to evaluate renal endpoints in a prospective manner. Results: The urine 5MedC level was significantly increased in the later stages of CKD compared to the early to middle stages of CKD. In multiple logistic regression models, urine 5MedC was significantly associated with the prediction of later CKD stages. Urine 5MedC (median value, 65.9 μmol/gCr) was significantly able to predict a 30% decline in the estimated GFR or a development of end-stage renal disease when combined with macroalbuminuria or an increased level of urine α1MG (median value, 5.7 mg/gCr). Conclusion: The present data demonstrate that the urine 5MedC level is associated with a reduced renal function and can serve as a novel and potent biomarker for predicting the renal outcome in CKD patients. Further studies will be necessary to elucidate the role of urine DNA methylation in the progression of CKD.

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  • Report of health checkup system for chronic kidney disease in general population in Okayama city: effect of health guidance intervention on chronic kidney disease outcome. Reviewed International journal

    Yuki Kakio, Haruhito A Uchida, Hidemi Takeuchi, Yuka Okuyama, Ryoko Umebayashi, Hiroyuki Watatani, Yohei Maeshima, Hitoshi Sugiyama, Jun Wada

    International journal of nephrology and renovascular disease   12   143 - 152   2019

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    Background: From 2011, Okayama municipal government started the health checkup follow-up project to find those who were unaware of suffering chronic kidney disease and to prevent from aggravation of CKD stage. In this study, we aimed to evaluate the effect of 2 years' CKD-follow-up project regarding renal function and CKD risks. Patients and methods: Those who received a health checkup by the national health insurance in Okayama city in 2011 were recruited. The patients with lifestyle-related diseases or metabolic syndrome were excluded. Subjects who had an estimated glomerular filtration rate<50 mL/min/1.73 m2 or urinary protein positive by dipstick test were defined as compromised renal function group. They were recommended to visit a medical institution. Non-compromised renal function participants with two or more risks for CKD (hyperglycemia, higher blood pressure, dyslipidemia, hyperuricemia) were recommended to receive a health guidance (risk group). The change of renal function and CKD risks between 2011 and 2013 in each group was examined. Results: A total of 28,309 people received a health checkup in 2011. In compromised renal function group, 39.5% (96/243) of the subjects improved their CKD stages in 2013 regardless of the visit of medical institutions or the frequency of receiving health checkup. In risk group, 63.4% (260/410) of the subjects decreased their CKD risks in 2013 independent of the reception of health guidance. Conclusion: In both compromised renal function group and risk group, more than half of subjects kept their kidney function (217/243) and decreased the number of CKD risks (260/410) in 2 years' follow-up. Receiving a health checkup itself and notification of one's own health condition could exert a protective effect on kidney function.

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  • Abdominal aortic aneurysm in aged population. Reviewed International journal

    Ryoko Umebayashi, Haruhito A Uchida, Jun Wada

    Aging   10 ( 12 )   3650 - 3651   2018.12

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  • Diabetic nephropathy is associated with frailty in patients with chronic hemodialysis. Reviewed

    Yuki Kakio, Haruhito A Uchida, Hidemi Takeuchi, Yuka Okuyama, Michihiro Okuyama, Ryoko Umebayashi, Kentaro Wada, Hitoshi Sugiyama, Ken Sugimoto, Hiromi Rakugi, Shingo Kasahara, Jun Wada

    Geriatrics & gerontology international   18 ( 12 )   1597 - 1602   2018.12

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    AIM: Since 1998, the leading cause of chronic hemodialysis in Japan has been diabetic nephropathy. Diabetes mellitus is known to be a risk factor for frailty, but it still remains unknown whether diabetic nephropathy is associated with frailty in chronic dialysis patients. The authors carried out the present study to reveal the association between frailty and diabetic nephropathy in chronic hemodialysis patients. METHODS: A total of 355 patients who were on hemodialysis were recruited. Participants were divided into two groups of either patients who suffered diabetic nephropathy with end-stage renal disease (DN group, n = 150) or not (Non-DN group, n = 205). The authors investigated the difference of the prevalence of frailty between the two groups. Furthermore, the authors examined the risk factors for frailty. RESULTS: The prevalence of frailty in the DN group was significantly higher than that in the Non-DN group (28.0% vs 16.5%, P = 0.0161). To evaluate the association between frailty and its risk factors, we compared frail patients (n = 71) and non-frail patients (n = 262). After adjusting their interrelationships by using multivariate logistic regression analysis, diabetic nephropathy was determined as a significant risk factor for frailty. CONCLUSIONS: The authors found the close association between frailty and diabetic nephropathy in chronic hemodialysis patients. Geriatr Gerontol Int 2018; 18: 1597-1602.

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  • Chronic kidney disease is associated with carotid atherosclerosis and symptomatic ischaemic stroke. Reviewed International journal

    Nobuo Kajitani, Haruhito A Uchida, Isao Suminoe, Yuki Kakio, Masashi Kitagawa, Hajime Sato, Jun Wada

    The Journal of international medical research   46 ( 9 )   3873 - 3883   2018.9

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    Objective We aimed to investigate the relationships among chronic kidney disease (CKD), symptomatic ischaemic stroke, and carotid atherosclerosis. Methods We enrolled 455 patients who underwent carotid ultrasonography in our hospital, including 311 patients with symptomatic ischaemic stroke and 144 patients without symptomatic ischaemic stroke. Carotid intima-media thickness (IMT), the rate of internal carotid artery stenosis, and maximal plaque size were evaluated. Results The mean age of the patients was 68.5 ± 11.0 years and the mean estimated glomerular filtration rate (eGFR) was 68.8 ± 18.2 mL/min/1.73 m2. After adjustment for cardiovascular risk factors, the mean IMT was significantly higher in patients with CKD than in those without CKD. The IMT and eGFR were negatively correlated in patients with stroke (r = -0.169). Multiple logistic regression analyses showed that mean IMT, plaque size, and internal carotid artery stenosis were significant determinants of symptomatic ischaemic stroke after adjustment of multivariate risk factors. Furthermore, the eGFR was a negative determinant of symptomatic ischaemic stroke after adjusting for classical risk factors (odds ratio [95% confidence interval] = 0.868 [0.769-0.979]). Conclusion CKD might be associated with the carotid atherosclerosis and symptomatic ischaemic stroke.

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  • 末梢動脈疾患が中心血圧、aPWV、AIに与える影響の検討

    武本 梨佳, 内田 治仁, 垣尾 勇樹, 大高 望, 大西 康博, 秦 昌紫子, 北川 正史, 戸田 洋伸, 吉田 賢司, 大塚 文男, 杉山 斉, 伊藤 浩, 和田 淳

    日本高血圧学会総会プログラム・抄録集   41回   PM01 - 03   2018.9

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  • Coral reef aorta一連の病変と考えられた移植腎動脈狭窄に対する血管内治療の1例 Reviewed

    戸田 洋伸, 大塚 寛昭, 江尻 健太郎, 内田 治仁, 杜 徳尚, 中川 晃志, 渡邊 敦之, 三好 亨, 西井 伸洋, 中村 一文, 森田 宏, 伊藤 浩

    脈管学   58 ( Suppl. )   S206 - S206   2018.9

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  • 両大血管右室起始症患者の腎内血行動態を超音波ドプラ法で評価した1例

    大高 望, 杜 徳尚, 武本 梨佳, 渡辺 修久, 木野村 賢, 大西 康博, 垣尾 勇樹, 戸田 洋伸, 内田 治仁, 伊藤 浩, 和田 淳

    脈管学   58 ( Suppl. )   S209 - S210   2018.9

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  • Peripheral artery disease is associated with frailty in chronic hemodialysis patients. Reviewed International journal

    Michihiro Okuyama, Hidemi Takeuchi, Haruhito A Uchida, Yuki Kakio, Yuka Okuyama, Ryoko Umebayashi, Kentaro Wada, Hitoshi Sugiyama, Ken Sugimoto, Hiromi Rakugi, Shingo Kasahara, Jun Wada

    Vascular   26 ( 4 )   425 - 431   2018.8

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    Objectives The clinical condition of frailty is a common problem in the elderly population. However, the relationship between peripheral artery disease and frailty in hemodialysis patients remains unknown. The aim of this study was to identify the relationships between peripheral artery disease and frailty in Japanese chronic hemodialysis patients. Methods A total of 362 chronic hemodialysis patients who regularly visited six institutions were enrolled. To evaluate frailty, the modified Fried's frailty phenotype adjusted for Japanese were used. Peripheral artery disease was defined as ankle-brachial index <0.9. Results Of 362 patients, 62 patients (17.1%) were categorized as peripheral artery disease group and 300 patients (82.9%) as Non-peripheral artery disease group. The prevalence of frailty in the peripheral artery disease group was significantly higher than in the Non-peripheral artery disease group (34% vs. 18%, P = 0.0103). Non-shunt side grip strength was significantly stronger in the Non-peripheral artery disease group (23.6 kg vs. 17.0 kg, P < 0.0001). Thigh circumferences were also significantly larger in the Non-peripheral artery disease group (41.7 cm vs. 39.7 cm, P = 0.0054). A multivariate logistic regression analysis demonstrated that the factors independently associated with peripheral artery disease were as follows: frailty (odds ratio = 2.06, 95% confidence interval 1.09-3.89) and myocardial infarction (odds ratio = 3.74, 95% confidence interval 2.05-6.83). Conclusions It is concluded that peripheral artery disease is closely associated with frailty in hemodialysis patients.

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  • Identification of Novel Urinary Biomarkers for Predicting Renal Prognosis in Patients With Type 2 Diabetes by Glycan Profiling in a Multicenter Prospective Cohort Study: U-CARE Study 1. Reviewed International journal

    Koki Mise, Mariko Imamura, Satoshi Yamaguchi, Sanae Teshigawara, Atsuhito Tone, Haruhito A Uchida, Jun Eguchi, Atsuko Nakatsuka, Daisuke Ogawa, Michihiro Yoshida, Masao Yamada, Kenichi Shikata, Jun Wada

    Diabetes care   41 ( 8 )   1765 - 1775   2018.8

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    OBJECTIVE: Because quantifying glycans with complex structures is technically challenging, little is known about the association of glycosylation profiles with the renal prognosis in diabetic kidney disease (DKD). RESEARCH DESIGN AND METHODS: In 675 patients with type 2 diabetes, we assessed the baseline urinary glycan signals binding to 45 lectins with different specificities. The end point was a decrease of estimated glomerular filtration rate (eGFR) by ≥30% from baseline or dialysis for end-stage renal disease. RESULTS: During a median follow-up of 4.0 years, 63 patients reached the end point. Cox proportional hazards analysis revealed that urinary levels of glycans binding to six lectins were significantly associated with the outcome after adjustment for known indicators of DKD, although these urinary glycans, except that for DBA, were highly correlated with baseline albuminuria and eGFR. Hazard ratios for these lectins were (+1 SD for the glycan index) as follows: SNA (recognizing glycan Siaα2-6Gal/GalNAc), 1.42 (95% CI 1.14-1.76); RCA120 (Galβ4GlcNAc), 1.28 (1.01-1.64); DBA (GalNAcα3GalNAc), 0.80 (0.64-0.997); ABA (Galβ3GalNAc), 1.29 (1.02-1.64); Jacalin (Galβ3GalNAc), 1.30 (1.02-1.67); and ACA (Galβ3GalNAc), 1.32 (1.04-1.67). Adding these glycan indexes to a model containing known indicators of progression improved prediction of the outcome (net reclassification improvement increased by 0.51 [0.22-0.80], relative integrated discrimination improvement increased by 0.18 [0.01-0.35], and the Akaike information criterion decreased from 296 to 287). CONCLUSIONS: The urinary glycan profile identified in this study may be useful for predicting renal prognosis in patients with type 2 diabetes. Additional investigation of glycosylation changes and urinary glycan excretion in DKD is needed.

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  • 4年半後に再発した腎血管性高血圧の1例

    大高 望, 内田 治仁, 武本 梨佳, 大西 康博, 垣尾 勇樹, 奥山 由加, 梅林 亮子, 谷村 智史, 杉山 斉, 和田 淳

    日本腎臓学会誌   60 ( 6 )   771 - 771   2018.8

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  • 生体肝移植後に発症したAAアミロイドーシスの1例

    大西 康博, 北川 正史, 御舩 朋代, 福島 和彦, 渡邉 真由, 木野村 賢, 内田 治仁, 杉山 斉, 高木 章乃夫, 八木 孝仁, 和田 淳

    日本腎臓学会誌   60 ( 6 )   757 - 757   2018.8

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  • IgA Nephropathy Complicated with X-linked Thrombocytopenia. Reviewed

    Yuki Kakio, Haruhito Adam Uchida, Masashi Kitagawa, Yuka Arata, Ayako Kato, Akiko Inoue-Torii, Norikazu Hinamoto, Ayu Ogawa-Akiyama, Hitoshi Sugiyama, Jun Wada

    Acta medica Okayama   72 ( 3 )   301 - 307   2018.6

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    Renal involvement is occasionally observed in Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT). It has been reported that galactose-deficient IgA is a closely linked to IgA nephropathy (IgAN), suggesting that patients with XLT/WAS associated with reduced galactosylation on serum IgA are susceptible to IgAN. It is necessary to pay more attention to patients with IgAN due to the potential complication with XLT/WAS. We here present a patient of XLT complicated with mild IgAN who underwent tonsillectomy combined with steroid pulse therapy to achieve complete clinical remission.

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  • Cilostazol Attenuates Angiotensin II-Induced Abdominal Aortic Aneurysms but Not Atherosclerosis in Apolipoprotein E-Deficient Mice. Reviewed International journal

    Ryoko Umebayashi, Haruhito A Uchida, Yuki Kakio, Venkateswaran Subramanian, Alan Daugherty, Jun Wada

    Arteriosclerosis, thrombosis, and vascular biology   38 ( 4 )   903 - 912   2018.4

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    OBJECTIVE: Abdominal aortic aneurysm (AAA) is a permanent dilation of the abdominal aorta associated with rupture, which frequently results in fatal consequences. AAA tissue is commonly characterized by localized structural deterioration accompanied with inflammation and profound accumulation of leukocytes, although the specific function of these cells is unknown. Cilostazol, a phosphodiesterase III inhibitor, is commonly used for patients with peripheral vascular disease or stroke because of its anti-platelet aggregation effect and anti-inflammatory effect, which is vasoprotective effect. In this study, we evaluated the effects of cilostazol on angiotensin II-induced AAA formation. APPROACH AND RESULTS: Male apolipoprotein E-deficient mice were fed either normal diet or a diet containing cilostazol (0.1% wt/wt). After 1 week of diet consumption, mice were infused with angiotensin II (1000 ng/kg per minute) for 4 weeks. Angiotensin II infusion increased maximal diameters of abdominal aortas, whereas cilostazol administration significantly attenuated dilatation of abdominal aortas, thereby, reducing AAA incidence. Cilostazol also reduced macrophage accumulation, matrix metalloproteinases activation, and inflammatory gene expression in the aortic media. In cultured vascular endothelial cells, cilostazol reduced expression of inflammatory cytokines and adhesive molecules through activation of the cAMP-PKA (protein kinase A) pathway. CONCLUSIONS: Cilostazol attenuated angiotensin II-induced AAA formation by its anti-inflammatory effect through phosphodiesterase III inhibition in the aortic wall. Cilostazol may be a promising new therapeutic option for AAAs.

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  • The Prevalence of Frailty and its Associated Factors in Japanese Hemodialysis Patients. Reviewed International journal

    Hidemi Takeuchi, Haruhito A Uchida, Yuki Kakio, Yuka Okuyama, Michihiro Okuyama, Ryoko Umebayashi, Kentaro Wada, Hitoshi Sugiyama, Ken Sugimoto, Hiromi Rakugi, Jun Wada

    Aging and disease   9 ( 2 )   192 - 207   2018.4

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    The population undergoing dialysis is aging worldwide, particularly in Japan. The clinical condition of frailty is the most problematic expression in the elderly population. Potential pathophysiological factors of frailty present in patients with CKD and are accentuated in patients with ESRD. The aim of this study was to identify the prevalence and predictors of frailty in Japanese HD patients. This study was a multicenter, cross-sectional and observational investigation conducted at 6 institutions. To evaluate frailty, the modified Fried's frailty phenotype adjusted for Japanese as the self-reported questionnaire was used. Of the 542 patients visiting each institution, 388 were enrolled in this study. In total, 26.0% of participants were categorized as not-frailty, 52.6% as pre-frailty and 21.4% as frailty. The prevalence of frailty increased steadily with age and was more prevalent in females than in males and the subjects with frailty received polypharmacy. A multivariate logistic regression analysis revealed that the factors independently associated with frailty were the following: female gender (odds ratio [OR] = 3.661, 95% confidence interval [CI] 1.398-9.588), age (OR = 1.065, 95% CI 1.014-1.119), age ≥ 75 years old (OR = 4.892, 95% CI 1.715-13.955), body mass index (BMI) < 18.5 (OR = 0.110, 95% CI 0.0293-0.416), number of medications being taken (OR = 1.351, 95% CI 1.163-1.570), diabetes mellitus (DM) (OR = 2.765, 95% CI 1.081-7.071) and MNA-SF ≤ 11 (OR = 7.405, 95% CI 2.732-20.072). Frailty was associated with the accumulation of risk factors. The prevalence of frailty in Japanese patients with HD was relatively lower than that previously reported in Western developed countries; however, it was extremely high compared to the general population regardless of age. Our findings suggest that frailty might be associated with an increase in the prevalence of adverse health outcomes in patients with HD.

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  • 岡山市CKDネットワーク(OCKD-NET)におけるCKD病診連携7年後の追跡調査

    大西 康博, 内田 治仁, 大高 望, 奥山 由加, 田邊 克幸, 森永 裕士, 木野村 賢, 前島 洋平, 杉山 斉, 太田 康介, 平松 信, 大城 義之, 森岡 茂, 福島 正樹, 和田 淳

    日本腎臓学会誌   60 ( 3 )   399 - 399   2018.4

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  • 動脈硬化ではなく細動脈硝子化は糸球体全節性硬化と独立して尿細管間質病変と関連する

    北川 正史, 杉山 斉, 加納 弓月, 山成 俊夫, 田中 景子, 大西 章史, 内田 治仁, 和田 淳

    日本腎臓学会誌   60 ( 3 )   370 - 370   2018.4

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  • Impact of nocturnal blood pressure variability on renal arterioles. Reviewed International journal

    Haruhito A Uchida, Masashi Kitagawa, Jun Wada

    Hypertension research : official journal of the Japanese Society of Hypertension   41 ( 1 )   6 - 7   2018.1

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    DOI: 10.1038/hr.2017.88

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  • Serum cystatin C is an independent biomarker associated with the renal resistive index in patients with chronic kidney disease. Reviewed International journal

    Ayu Ogawa-Akiyama, Hitoshi Sugiyama, Masashi Kitagawa, Keiko Tanaka, Akifumi Onishi, Toshio Yamanari, Hiroshi Morinaga, Haruhito Adam Uchida, Kazufumi Nakamura, Hiroshi Ito, Jun Wada

    PloS one   13 ( 3 )   e0193695   2018

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    Cystatin C is a cysteine protease inhibitor that is produced by nearly all human cells. The serum level of cystatin C is a stronger predictor of the renal outcome and the risk of cardiovascular events than the creatinine level. The resistive index (RI) on renal Doppler ultrasonography is a good indicator of vascular resistance as well as the renal outcomes in patients with chronic kidney disease (CKD). However, it is unclear whether serum cystatin C is associated with signs of vascular dysfunction, such as the renal RI. We measured the serum cystatin C levels in 101 CKD patients and investigated the relationships between cystatin C and markers of vascular dysfunction, including the renal RI, ankle-brachial pulse wave velocity (baPWV), intima-media thickness (IMT), and cardiac function. The renal RI was significantly correlated with the serum cystatin C level (p < 0.0001, r = 0.6920). The serum cystatin C level was found to be a significant determinant of the renal RI (p < 0.0001), but not the baPWV, in a multivariate regression analysis. The multivariate odds ratio of the serum cystatin C level for a renal RI of more than 0.66 was statistically significant (2.92, p = 0.0106). The area under the receiver-operating characteristic curve comparing the sensitivity and specificity of cystatin C for predicting an RI of more than 0.66 was 0.882 (cutoff value: 2.04 mg/L). In conclusion, the serum cystatin C level is an independent biomarker associated with the renal RI in patients with CKD.

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  • 閉塞性動脈硬化症診断におけるトレッドミル負荷ABIの有用性

    武本 梨佳, 戸田 洋伸, 越智 真金, 大塚 寛昭, 江尻 健太郎, 内田 治仁, 岡田 健, 大塚 文男, 和田 淳, 伊藤 浩

    脈管学   57 ( Suppl. )   S260 - S260   2017.10

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  • Poor glycemic control attributable to insulin antibody in a fulminant type 1 diabetes patient under hemodialysis: successful treatment with double filtration plasmapheresis and prednisolone Reviewed

    Kentaro Wada, Haruhito A. Uchida, Yuko Wada

    Renal Replacement Therapy   3 ( 1 )   2017.4

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    DOI: 10.1186/s41100-017-0096-9

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  • Practical efficacy of olmesartan versus azilsartan in patients with hypertension: a multicenter randomized-controlled trial (MUSCAT-4 study). Reviewed International journal

    Yuki Kakio, Haruhito A Uchida, Ryoko Umebayashi, Hidemi Takeuchi, Yuka Okuyama, Yoshihisa Hanayama, Jun Wada

    Blood pressure monitoring   22 ( 2 )   59 - 67   2017.4

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    BACKGROUND: Olmesartan and azilsartan, angiotensin II receptor blockers (ARBs), are expected to decrease blood pressure more than the other ARBs. We conducted randomized-controlled trials to compare the practical efficacy of olmesartan with azilsartan. METHODS: Eighty-four patients treated with the conventional ARBs for more than 3 months were assigned randomly to receive either 20 mg of olmesartan (olmesartan medoxomil, OL group) or 20 mg of azilsartan (azilsartan, not azilsartan medoxomil, AZ group) once daily for 16 weeks. The practical efficacy on blood pressure was compared between the OL and AZ groups. RESULTS: Office blood pressure of both groups decreased significantly (OL group: 152/86-141/79 mmHg, P<0.05, AZ group: 149/83-135/75 mmHg; P<0.05). Diastolic home blood pressure in the AZ group decreased significantly (79±9-74±7 mmHg; P<0.05), but not in the OL group (79±11-75±10 mmHg; P=0.068). However, there were no significant differences between the groups. The dosage of olmesartan and azilsartan increased significantly and slightly for 16 weeks (OL group: 20.3-23.1 mg; P<0.05, AZ group: 20.5-23.2 mg; P<0.05), without a significant difference between groups. Furthermore, there were no significant differences in renal function, lipid profiles, brain natriuretic peptide, soluble fms-like tyrosine kinase-1, and urinary L-type fatty acid-binding protein between the two groups. CONCLUSION: Both olmesartan and azilsartan equally reduced blood pressures. Both olmesartan and azilsartan showed a renoprotective effect and were well tolerated without any major adverse events.

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  • baPWVによる動脈硬化評価は腎生検後の貧血進行の予測因子となる

    田中 景子, 北川 正史, 大西 章史, 山成 俊夫, 秋山 愛由, 三瀬 広記, 森永 裕士, 内田 治仁, 杉山 斉, 和田 淳

    日本腎臓学会誌   59 ( 3 )   345 - 345   2017.4

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  • 腎内細動脈硝子化、動脈硬化病変は全身の動脈硬化指標の異なる因子が規定する

    北川 正史, 杉山 斉, 大西 章史, 山成 俊夫, 田中 景子, 三瀬 広記, 森永 裕士, 内田 治仁, 和田 淳

    日本腎臓学会誌   59 ( 3 )   309 - 309   2017.4

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  • Effectiveness case of Jidabokuippo (traditional Japanese Kampo medicine) on pain, venous thrombosis, and subcutaneous hematoma after percutaneous femoral catheterization in a hemodialysis patient Reviewed

    Kentaro Wada, Haruhito A. Uchida, Yuko Wada

    Renal Replacement Therapy   3 ( 1 )   2017.1

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    DOI: 10.1186/s41100-016-0086-3

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  • Arterial Stiffness is an Independent Risk Factor for Anemia After Percutaneous Native Kidney Biopsy. Reviewed International journal

    Keiko Tanaka, Masashi Kitagawa, Akifumi Onishi, Toshio Yamanari, Ayu Ogawa-Akiyama, Koki Mise, Tatsuyuki Inoue, Hiroshi Morinaga, Haruhito A Uchida, Hitoshi Sugiyama, Jun Wada

    Kidney & blood pressure research   42 ( 2 )   284 - 293   2017

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    BACKGROUND/AIMS: Bleeding is the most common complication after renal biopsy. Although numerous predictors of bleeding have been reported, it remains unclear whether arterial stiffness affects bleeding complications. METHOD: We performed an observational study of the renal biopsies performed in our division over an approximately 6-year period (May 2010 to May 2016). The clinical and laboratory factors were analyzed to reveal the risk factors associated with bleeding, with a focus on anemia (defined as a ≥10% decrease in hemoglobin [Hb] after biopsy). The brachial-ankle pulse wave velocity (baPWV) was measured to evaluate arterial stiffness. RESULTS: This study included 462 patients (male, n=244; female, n=218). Anemia (defined above) was observed in 54 patients (11.7%). The risk of anemia was higher in women, older patients, and patients with lower serum albumin, lower eGFR and lower diastolic blood pressure after biopsy. We then performed a further analysis of 187 patients whose baPWV data were available. Multivariate analysis revealed that a higher baPWV was an independent risk factor for anemia. ROC analysis for predicting anemia found that a baPWV value of 1839 cm/s had the best performance (AUC 0.689). CONCLUSION: An increased baPWV may be a more valuable predictor of bleeding than any of the other reported risk factors.

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  • The possible involvement of intestine-derived IgA1: a case of IgA nephropathy associated with Crohn's disease. Reviewed International journal

    Tomohiro Terasaka, Haruhito A Uchida, Ryoko Umebayashi, Keiko Tsukamoto, Keiko Tanaka, Masashi Kitagawa, Hitoshi Sugiyama, Hiroaki Tanioka, Jun Wada

    BMC nephrology   17 ( 1 )   122 - 122   2016.9

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    BACKGROUND: A link between IgA nephropathy and Crohn's disease has recently been reported. Other researchers hypothesize that intestine-derived IgA complexes deposit in glomerular mesangial cells, eliciting IgA nephropathy. Intestinal mucosal plasma cells mainly secrete IgA2. Nevertheless, IgA1 deposition is strongly implicated as being the primary cause of IgA nephropathy. CASE PRESENTATION: A 46-year-old Japanese man developed IgA nephropathy 29 years ago, following tonsillectomy. As a result, a normal urinalysis was obtained. The patient previously suffered Crohn's disease followed by urinary occult blood and proteinuria six years ago. Exacerbation of IgA nephropathy was highly suspected. Therefore a renal biopsy was performed. A diagnosis of exacerbation of IgA nephropathy with mesangial cell proliferation and fibrotic cellular crescent was based upon the pathological findings. The patient exhibited a positive clinical course and eventually achieved a remission with immunosuppressive therapy including prednisolone treatment. Immunostaining for the detection of IgA subtypes was performed on both of his kidney and excised ileum. The results revealed IgA1 and IgA2 deposition by submucosal cells in intestine. Furthermore, IgA1 deposition of mesangial areas in the patient's kidney, indicated an association of IgA1 with the exacerbation of IgA nephropathy. CONCLUSION: This case represents the possibility that the intestine-derived IgA1 can be the origin of galactose-deficient IgA which is known to cause IgA nephropathy exacerbation.

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  • The Possible Association of the Incidence of ESRD in the Patient with Diabetic Nephropathy with Salt Intake in the World Reviewed

    Haruhito A. Uchida, Jun Wada, Hirofumi Makino

    BMJ open e-letter   2016.8

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  • Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice. Reviewed International journal

    Deborah A Howatt, Anju Balakrishnan, Jessica J Moorleghen, Latha Muniappan, Debra L Rateri, Haruhito A Uchida, Jiro Takano, Takaomi C Saido, Athar H Chishti, Laurent Baud, Venkateswaran Subramanian

    Arteriosclerosis, thrombosis, and vascular biology   36 ( 5 )   835 - 45   2016.5

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    OBJECTIVE: Angiotensin II (AngII) infusion profoundly increases activity of calpains, calcium-dependent neutral cysteine proteases, in mice. Pharmacological inhibition of calpains attenuates AngII-induced aortic medial macrophage accumulation, atherosclerosis, and abdominal aortic aneurysm in mice. However, the precise functional contribution of leukocyte-derived calpains in AngII-induced vascular pathologies has not been determined. The purpose of this study was to determine whether calpains expressed in bone marrow (BM)-derived cells contribute to AngII-induced atherosclerosis and aortic aneurysms in hypercholesterolemic mice. APPROACH AND RESULTS: To study whether leukocyte calpains contributed to AngII-induced aortic pathologies, irradiated male low-density lipoprotein receptor(-/-) mice were repopulated with BM-derived cells that were either wild-type or overexpressed calpastatin, the endogenous inhibitor of calpains. Mice were fed a fat-enriched diet and infused with AngII (1000 ng/kg per minute) for 4 weeks. Overexpression of calpastatin in BM-derived cells significantly attenuated AngII-induced atherosclerotic lesion formation in aortic arches, but had no effect on aneurysm formation. Using either BM-derived cells from calpain-1-deficient mice or mice with leukocyte-specific calpain-2 deficiency generated using cre-loxP recombination technology, further studies demonstrated that independent deficiency of either calpain-1 or -2 in leukocytes modestly attenuated AngII-induced atherosclerosis. Calpastatin overexpression significantly attenuated AngII-induced inflammatory responses in macrophages and spleen. Furthermore, calpain inhibition suppressed migration and adhesion of macrophages to endothelial cells in vitro. Calpain inhibition also significantly decreased hypercholesterolemia-induced atherosclerosis in the absence of AngII. CONCLUSIONS: The present study demonstrates a pivotal role for BM-derived calpains in mediating AngII-induced atherosclerosis by influencing macrophage function.

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  • 腎機能障害を合併した治療抵抗性高血圧症の一例

    遠藤 豊宏, 内田 治仁, 谷村 智史, 三瀬 広記, 井上 達之, 竹内 英実, 垣尾 勇樹, 梅林 亮子, 杉山 斉, 和田 淳

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   5回   181 - 181   2016.5

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  • Acute idiopathic blue fingers: a young man with Achenbach's syndrome. Reviewed International journal

    Hidemi Takeuchi, Haruhito Adam Uchida, Yuka Okuyama, Jun Wada

    BMJ case reports   2016   10.1136/bcr-2016-214491   2016.4

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    We report a case of a 20-year-old man presenting with acute painful blue fingers. All physical findings, including an Allen test, were normal, and systematic symptoms frequently seen in collagen diseases were absent. Although we performed a wide variety of investigations including medical imaging, no specific abnormal findings were observed. Skin biopsy pathology was an important reference. The patient's symptoms gradually improved and were completely resolved without specific treatment. Based on the clinical presentation and course, we gave a diagnosis of Achenbach's syndrome, developed in a young male. Achenbach's syndrome is rare, but still may be encountered in clinical practice. The symptoms can be startling to the patient, eliciting fear of something terrible when, in fact, the syndrome is relatively benign and has a good prognosis. Recognising this disease quickly after presentation helps to eliminate the anxiety of the patient, as well as reducing excessively invasive investigations. We present a case report to enlighten Achenbach's syndrome.

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  • Chronic Kidney Disease Is Positively and Diabetes Mellitus Is Negatively Associated with Abdominal Aortic Aneurysm. Reviewed International journal

    Hidemi Takeuchi, Michihiro Okuyama, Haruhito A Uchida, Yuki Kakio, Ryoko Umebayashi, Yuka Okuyama, Yasuhiro Fujii, Susumu Ozawa, Masashi Yoshida, Yu Oshima, Shunji Sano, Jun Wada

    PloS one   11 ( 10 )   e0164015   2016

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    BACKGROUND AND AIMS: Chronic kidney disease (CKD) and diabetes mellitus (DM) are considered as risk factors for cardiovascular diseases. The purpose of this study was to clarify the relationship of CKD and DM with the presence of abdominal aortic aneurysm (AAA). METHODS: We enrolled 261 patients with AAA (AAA+) and age-and-sex matched 261 patients without AAA (AAA-) at two hospitals between 2008 and 2014, and examined the association between the risk factors and the presence of AAA. Furthermore, in order to investigate the prevalence of AAA in each group, we enrolled 1126 patients with CKD and 400 patients with DM. RESULTS: The presence of CKD in patients with AAA+ was significantly higher than that in patients with AAA- (AAA+; 65%, AAA-; 52%, P = 0.004). The presence of DM in patients with AAA+ was significantly lower than that in patients with AAA- (AAA+; 17%, AAA-; 35%, P < 0.001). A multivariate logistic regression analysis demonstrated that hypertension, ischemic heart disease and CKD were independent determinants, whereas, DM was a negatively independent determinant, for the presence of AAA. The prevalence of AAA in patients with CKD 65 years old and above was 5.1%, whereas, that in patients with DM 65 years old and above was only 0.6%. CONCLUSION: CKD is a positively associated with the presence of AAA. In contrast, DM is a negatively associated with the presence of AAA in Japanese population.

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  • Successful treatment by mycophenolate mofetil in a patient with focal segmental glomerulosclerosis associated with posterior reversible encephalopathy syndrome. Reviewed

    Masafumi Tenta, Haruhito Adam Uchida, Tomokazu Nunoue, Ryoko Umebayashi, Yuka Okuyama, Masashi Kitagawa, Yohei Maeshima, Hitoshi Sugiyama, Jun Wada

    CEN case reports   4 ( 2 )   190 - 195   2015.11

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    It has been reported that cyclosporine A (CsA) treatment may be associated with posterior reversible encephalopathy syndrome. We report a 16-year-old man who exhibited nephrotic syndrome and posterior reversible encephalopathy syndrome. Intensive antihypertensive therapy restored him to consciousness. Renal biopsy revealed that he suffered from focal segmental glomerulosclerosis. Although he was treated with prednisolone and low-density lipoprotein apheresis therapy, his proteinuria remained at high level. Then, mycophenolate mofetil (MMF) with less influence on vessel endothelium compared with CsA and tacrolimus was administered. Soon after, he reached remission of nephrotic syndrome without recurrence of posterior reversible encephalopathy syndrome. This is the first case that a young patient of focal segmental glomerulosclerosis with posterior reversible encephalopathy syndrome achieved a complete remission by MMF treatment without recurrence of posterior reversible encephalopathy syndrome. MMF may be effective for young patients of focal segmental glomerulosclerosis especially with clinical condition of vascular endothelial damage such as posterior reversible encephalopathy syndrome.

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  • 有痛性手指チアノーゼを来した若年男性の1例

    竹内 英実, 内田 治仁, 奥山 由加, 垣尾 勇樹, 梅林 亮子, 武本 梨佳, 戸田 洋伸, 藤井 泰宏, 大澤 晋, 村上 和敏, 大塚 文男, 和田 淳

    脈管学   55 ( Suppl. )   S246 - S247   2015.10

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  • 下大静脈フィルター閉塞が誘因となった症候性下肢動静脈瘻の2症例 Reviewed

    大澤 晋, 藤井 泰宏, 藤原 寛康, 増田 善逸, 黒子 洋介, 戸田 洋伸, 内田 治仁, 村上 和敏, 江尻 健太郎, 高樽 由美, 料治 三恵, 逢坂 大樹, 竹内 英実, 武本 梨佳, 本田 雅子, 三宅 麻希, 佐野 俊二

    脈管学   55 ( Suppl. )   S212 - S212   2015.10

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  • Retrograde Renal Ablation via the Renal Vein as a New Treatment Option for Renovascular Hypertension. Reviewed International journal

    Hiroyasu Fujiwara, Hideo Gobara, Takao Hiraki, Toshihiro Iguchi, Haruhito Adam Uchida, Susumu Kanazawa

    Journal of vascular and interventional radiology : JVIR   26 ( 6 )   807 - 8   2015.6

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    DOI: 10.1016/j.jvir.2015.01.030

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  • 血中FGF21は腎機能、蛋白尿と独立した腎予後を予測するバイオマーカーである

    北川 正史, 杉山 斉, 森永 裕士, 秋山 愛由, 山成 俊夫, 大西 章史, 田中 景子, 菊本 陽子, 井上 達之, 内田 治仁, 和田 淳

    日本腎臓学会誌   57 ( 3 )   465 - 465   2015.4

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  • Autoimmune pancreatitis and minimal change nephrotic syndrome: an unusual association? Reviewed International journal

    Yuka Okuyama, Haruhito Adam Uchida, Masafumi Tenta, Tomokazu Nunoue, Ryoko Umebayashi, Hiroshi Morinaga, Shinji Kitamura, Yohei Maeshima, Hitoshi Sugiyama, Jun Wada

    Nephrology (Carlton, Vic.)   20 ( 3 )   225 - 6   2015.3

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  • Effects of lanthanum carbonate versus calcium carbonate on vascular stiffness and bone mineral metabolism in hemodialysis patients with type 2 diabetes mellitus: a randomized controlled trial. Reviewed International journal

    Kentaro Wada, Yuko Wada, Haruhito Adam Uchida, Shuichi Tsuruoka

    International journal of nephrology and renovascular disease   8   111 - 8   2015

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    BACKGROUND: Vascular calcification contributes to cardiovascular disease in hemodialysis (HD) patients with diabetes. The randomized controlled trial reported here compared the effects of lanthanum carbonate (LC) and calcium carbonate (CC) on vascular stiffness assessed using brachial-ankle pulse wave velocity (ba-PWV), intima-media thickness (IMT), bone mineral density (BMD), and serum markers of chronic kidney disease - mineral and bone disorder in such patients. METHODS: Ba-PWV, IMT, BMD, and the biomarkers osteocalcin (OC) and bone alkaline phosphatase (BAP) were examined in 43 type 2 diabetes HD patients treated with LC (n=21) or CC (n=22) for 2 years. RESULTS: Forty-one patients completed the study (19, LC; 22, CC). The mean ba-PWV significantly increased only in the CC group (median: 2,280.5 to 2,402.5 cm/s, P<0.05), after 24-month treatment; it remained unchanged in the LC group (median: 1,830.5 to 2,018.3 cm/s). However, the difference between the groups did not reach statistical significance. Changes in IMT and BMD were not different between the two groups. Changes in serum phosphorus, corrected calcium, and intact parathyroid hormone levels were similar between the groups. The incidence of fracture was 0% (0/19) in the LC group, and 13.6% (3/22) in the CC group (P=0.2478). The OC/BAP ratio increased significantly in the LC group (median: 0.83 to 2.47), compared with in the CC group (median: 0.77 to 1.40) (P=0.036). CONCLUSION: From this study, in Japanese type 2 diabetes HD patients, we conclude that 2-year treatment with LC might have slowed the progression of ba-PWV; however, it did not cause a difference in ba-PWV, IMT, BMD, or fracture, compared with CC. Further, LC increased the OC/BAP ratio to a greater extent than CC.

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  • 当科で施行した生体腎移植レシピエント、ドナーのQOL評価

    有吉 勇一, 荒木 元朗, 宗石 理沙, 吉岡 貴史, 和田 耕一郎, 小林 泰之, 佐々木 克己, 江原 伸, 渡辺 豊彦, 那須 保友, 公文 裕巳, 有森 千聖, 北川 正史, 田邊 克幸, 森永 裕士, 菊本 陽子, 内田 治仁, 喜多村 真治, 前島 洋平, 杉山 斉, 槇野 博史

    移植   49 ( 4-5 )   377 - 377   2014.11

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  • Acute Effect of Aliskiren on Smoking-Induced Endothelial Dysfunction in Smoker Reviewed

    Haruhito A. Uchida, Hatsuzo Uchida, Jun Wada

    Journal of Cardiovascular Medicine and Cardiology   038 - 041   2014.10

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    DOI: 10.17352/2455-2976.000010

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  • 潰瘍性大腸炎に合併した腎血管性高血圧の1例

    田中 景子, 内田 治仁, 平松 澄恵, 天田 雅文, 井上 章子, 奥山 由加, 梅林 亮子, 郷原 英夫, 大澤 晋, 平岡 佐規子, 寺坂 律子, 杉山 斉, 和田 淳

    脈管学   54 ( 10 )   167 - 172   2014.10

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    腎血管性高血圧はさまざまな疾患を原因とする。今回我々は、潰瘍性大腸炎に腎血管性高血圧を合併した症例を経験した。症例は40歳男性。造影CTと血管造影で右腎動脈の閉塞と側副血行路の発達を認めた。さらに左腎区域動脈と肝動脈の狭小化、両側内腸骨動脈の閉塞と腹部大動脈の一部壁不整がみられた。FDG-PETで大動脈炎症候群は否定的であった。皮疹や結腸粘膜の生検で血管炎の所見は得られず、診断に苦慮した症例であった。(著者抄録)

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  • インターフェロン(IFN)が著効した生体肝移植後HCV陽性の膜性増殖性糸球体腎炎(MPGN)の1例

    田中 景子, 内田 治仁, 井上 章子, 雛元 紀和, 北川 正史, 高木 章乃夫, 杉山 斉, 和田 淳

    日本腎臓学会誌   56 ( 6 )   702 - 702   2014.8

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  • Large vessel vasculitis with myelodysplastic syndrome. Reviewed

    Takayuki Katsuyama, Haruhito Adam Uchida, Kishio Toma, Yoshinobu Maeda, Daisho Hirota, Ryoko Umebayashi, Ken-Ei Sada, Hirofumi Makino

    Internal medicine (Tokyo, Japan)   53 ( 1 )   63 - 6   2014

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    A 71-year-old woman presented with a high-grade fever, neck pain, anemia and thrombocytopenia. After performing further examinations, we concluded that she had simultaneously developed large vessel vasculitis and myelodysplastic syndrome (MDS). Although glucocorticoid administration improved her clinical symptoms, the MDS transformed into acute myeloid leukemia and she died one year after receiving the diagnosis. The occurrence of immune-mediated disorders in patients with MDS is a well-known phenomenon; however, large vessel vasculitis is a rare complication of MDS. Our case suggests that the association between systemic vasculitis and MDS may result in poor outcomes.

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  • MPO-ANCA関連腎炎と膜性腎症を合併した3症例の検討

    益田 加奈, 内田 治仁, 細谷 武史, 林 啓悟, 辻 憲二, 小川 愛由, 氏家 はる代, 梅林 亮子, 喜多村 真治, 前島 洋平, 杉山 斉, 槇野 博史

    日本腎臓学会誌   55 ( 6 )   1179 - 1179   2013.8

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  • The effects of telmisartan treatment on the abdominal fat depot in patients with metabolic syndrome and essential hypertension: Abdominal fat Depot Intervention Program of Okayama (ADIPO). Reviewed International journal

    Kazutoshi Murakami, Jun Wada, Daisuke Ogawa, Chikage Sato Horiguchi, Tomoko Miyoshi, Motofumi Sasaki, Haruhito A Uchida, Yoshio Nakamura, Hirofumi Makino

    Diabetes & vascular disease research   10 ( 1 )   93 - 6   2013.1

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    Telmisartan partially activates the peroxisome proliferator-activated receptor γ (PPARγ), which may ameliorate the accumulation of visceral adipose tissues and sensitise insulin action. Nineteen patients with essential hypertension and metabolic syndrome were randomly assigned to receive 40 mg of telmisartan (TELMI group) once daily or 80 mg of valsartan (VAL group) once daily for 24 weeks. The visceral fat area (VFA) measured by computed tomography (CT) was significantly reduced from 150.4±15.5 to 127.7±16.7 cm(2) in the TELMI group (p=0.049). Although VFA was also reduced in the VAL group from 169.8±14.8 to 155.3±14.8 cm(2), the change was not significant (p=0.173). There were no significant changes in body weight, body mass index (BMI), waist circumference, subdermal fat area (SFA), fasting plasma glucose, and homeostasis model assessment of insulin resistance (HOMA-IR) in comparison to the baseline and follow-up data in both groups. In conclusion, telmisartan may have a benefit in the reduction of visceral adipose tissues in comparison to valsartan.

    DOI: 10.1177/1479164112444640

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  • A decreased level of serum soluble Klotho is an independent biomarker associated with arterial stiffness in patients with chronic kidney disease. Reviewed International journal

    Masashi Kitagawa, Hitoshi Sugiyama, Hiroshi Morinaga, Tatsuyuki Inoue, Keiichi Takiue, Ayu Ogawa, Toshio Yamanari, Yoko Kikumoto, Haruhito Adam Uchida, Shinji Kitamura, Yohei Maeshima, Kazufumi Nakamura, Hiroshi Ito, Hirofumi Makino

    PloS one   8 ( 2 )   e56695   2013

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    BACKGROUND: Klotho was originally identified in a mutant mouse strain unable to express the gene that consequently showed shortened life spans. In humans, low serum Klotho levels are related to the prevalence of cardiovascular diseases in community-dwelling adults. However, it is unclear whether the serum Klotho levels are associated with signs of vascular dysfunction such as arterial stiffness, a major determinant of prognosis, in human subjects with chronic kidney disease (CKD). METHODS: We determined the levels of serum soluble Klotho in 114 patients with CKD using ELISA and investigated the relationship between the level of Klotho and markers of CKD-mineral and bone disorder (CKD-MBD) and various types of vascular dysfunction, including flow-mediated dilatation, a marker of endothelial dysfunction, ankle-brachial pulse wave velocity (baPWV), a marker of arterial stiffness, intima-media thickness (IMT), a marker of atherosclerosis, and the aortic calcification index (ACI), a marker of vascular calcification. RESULTS: The serum Klotho level significantly correlated with the 1,25-dihydroxyvitamin D level and inversely correlated with the parathyroid hormone level and the fractional excretion of phosphate. There were significant decreases in serum Klotho in patients with arterial stiffness defined as baPWV≥1400 cm/sec, atherosclerosis defined as maximum IMT≥1.1 mm and vascular calcification scores of ACI>0%. The serum Klotho level was a significant determinant of arterial stiffness, but not endothelial dysfunction, atherosclerosis or vascular calcification, in the multivariate analysis in either metabolic model, the CKD model or the CKD-MBD model. The adjusted odds ratio of serum Klotho for the baPWV was 0.60 (p = 0.0075). CONCLUSIONS: Decreases in the serum soluble Klotho levels are independently associated with signs of vascular dysfunction such as arterial stiffness in patients with CKD. Further research exploring whether therapeutic approaches to maintain or elevate the Klotho level could improve arterial stiffness in CKD patients is warranted.

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  • Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice. Reviewed International journal

    Venkateswaran Subramanian, Jessica J Moorleghen, Anju Balakrishnan, Deborah A Howatt, Athar H Chishti, Haruhito A Uchida

    PloS one   8 ( 8 )   e72214   2013

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    BACKGROUND AND OBJECTIVE: Recently, we demonstrated that angiotensin II (AngII)-infusion profoundly increased both aortic protein and activity of calpains, calcium-activated cysteine proteases, in mice. In addition, pharmacological inhibition of calpain attenuated AngII-induced abdominal aortic aneurysm (AA) in mice. Recent studies have shown that AngII infusion into mice leads to aneurysmal formation localized to the ascending aorta. However, the precise functional contribution of calpain isoforms (-1 or -2) in AngII-induced abdominal AA formation is not known. Similarly, a functional role of calpain in AngII-induced ascending AA remains to be defined. Using BDA-410, an inhibitor of calpains, and calpain-1 genetic deficient mice, we examined the relative contribution of calpain isoforms in AngII-induced ascending and abdominal AA development. METHODOLOGY/RESULTS: To investigate the relative contribution of calpain-1 and -2 in development of AngII-induced AAs, male LDLr -/- mice that were either calpain-1 +/+ or -/- were fed a saturated fat-enriched diet and infused with AngII (1,000 ng/kg/min) for 4 weeks. Calpain-1 deficiency had no significant effect on body weight or blood pressure during AngII infusion. Moreover, calpain-1 deficiency showed no discernible effects on AngII-induced ascending and abdominal AAs. Interestingly, AngII infusion induced increased expression of calpain-2 protein, thus compensating for total calpain activity in aortas of calpain-1 deficient mice. Oral administration of BDA-410, a calpain inhibitor, along with AngII-infusion significantly attenuated AngII-induced ascending and abdominal AA formation in both calpain-1 +/+ and -/- mice as compared to vehicle administered mice. Furthermore, BDA-410 administration attenuated AngII-induced aortic medial hypertrophy and macrophage accumulation. Western blot and immunostaining analyses revealed BDA-410 administration attenuated AngII-induced C-terminal fragmentation of filamin A, an actin binding cytoskeletal protein in aorta. CONCLUSION: Calpain-2 compensates for loss of calpain-1, and both calpain isoforms are involved in AngII-induced aortic aneurysm formation in mice.

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  • Case of emphysematous cholecystitis in a patient with type 2 diabetes mellitus associated with schizophrenia. Reviewed

    Ayu Ogawa, Kenichi Shikata, Haruhito Adam Uchida, Susumu Shinoura, Naosuke Yokomichi, Daisuke Ogawa, Chicage Sato-Horiguchi, Takahito Yagi, Jun Wada, Hirofumi Makino

    Journal of diabetes investigation   3 ( 6 )   534 - 5   2012.12

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    Emphysematous cholecystitis is a rare, but life-threatening, form of acute cholecystitis caused by gas-forming organisms in the gallbladder. A 73-year-old male patient with type 2 diabetes mellitus complicated with neuropathy associated with schizophrenia was admitted to Okayama University Hospital, Okayama, Japan, because of a high fever and general malaise. On the fourth hospital day, despite normal liver function tests and little abdominal pain, his abdominal computed tomography showed huge gas formation in the gallbladder lumen along with a dilated gallbladder with a thickened wall, consistent with emphysematous cholecystitis. The patient underwent an emergency open cholecystectomy. Few abdominal symptoms appeared because of the hyposensitivity to pain caused by not only diabetic neuropathy, but also antipsychotic agents the patient was taking for schizophrenia. Emphysematous cholecystitis should be taken into consideration for the differential diagnosis of high fever in diabetic patients with schizophrenia, irrespective of the level of liver function tests and clinical symptoms.

    DOI: 10.1111/j.2040-1124.2012.00232.x

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  • Activation of liver X receptor inhibits osteopontin and ameliorates diabetic nephropathy. Reviewed International journal

    Hiromi Tachibana, Daisuke Ogawa, Yuichi Matsushita, Dennis Bruemmer, Jun Wada, Sanae Teshigawara, Jun Eguchi, Chikage Sato-Horiguchi, Haruhito Adam Uchida, Kenichi Shikata, Hirofumi Makino

    Journal of the American Society of Nephrology : JASN   23 ( 11 )   1835 - 46   2012.11

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    Osteopontin is a proinflammatory cytokine and monocyte chemoattractant implicated in the pathogenesis of diabetic nephropathy. Synthetic agonists for liver X receptors (LXRs) suppress the expression of proinflammatory genes, including osteopontin, but whether LXR activation modulates diabetic nephropathy is unknown. We administered the LXR agonist T0901317 to mice with streptozotocin-induced diabetes and evaluated its effects on diabetic nephropathy. The LXR agonist decreased urinary albumin excretion without altering blood glucose levels and substantially attenuated macrophage infiltration, mesangial matrix accumulation, and interstitial fibrosis. LXR activation suppressed the gene expression of inflammatory mediators, including osteopontin, in the kidney cortex. In vitro, LXR activation suppressed osteopontin expression in proximal tubular epithelial cells by inhibiting AP-1-dependent transcriptional activation of the osteopontin promoter. Taken together, these results suggest that inhibition of renal osteopontin by LXR agonists may have therapeutic potential for diabetic nephropathy.

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  • A case of focal segmental glomerulosclerosis in an adult patient with hypogammaglobulinemia superimposed on membranoproliferative glomerulonephritis in childhood. Reviewed International journal

    Kenji Tsuji, Haruhito Adam Uchida, Tetsuichirou Ono, Tatsuyuki Inoue, Katsuji Shinagawa, Shinji Kitamura, Yohei Maeshima, Hitoshi Sugiyama, Hirofumi Makino

    BMC nephrology   13   46 - 46   2012.6

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    BACKGROUND: Common variable immunodeficiency (CVID) is a disorder characterized by hypogammaglobulinemia without a known predisposing cause. CASE PRESENTATION: We report a 36-year-old man who had suffered membranoproliferative glomerulonephritis (MPGN) in his childhood, later diagnosed with CVID at 35 years of age. He presented at our hospital with signs of proteinuria. A renal biopsy revealed he suffered from focal segmental glomerulosclerosis (FSGS), possibly due to obesity and hypertension, not CVID - associated MPGN. CONCLUSION: This is the first case report of FSGS in a CVID patient. In this case, we have to pay attention not only to the treatment of obesity and hypertension for FSGS but also to the recurrence of immune-complex glomerulonephritis such as MPGN, in case of the restoration of hypogammaglobulinemia.

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  • Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophage: anti-inflammatory effect of cholecystokinin. Reviewed International journal

    Satoshi Miyamoto, Kenichi Shikata, Kyoko Miyasaka, Shinichi Okada, Motofumi Sasaki, Ryo Kodera, Daisho Hirota, Nobuo Kajitani, Tetsuharu Takatsuka, Hitomi Usui Kataoka, Shingo Nishishita, Chikage Sato, Akihiro Funakoshi, Hisakazu Nishimori, Haruhito Adam Uchida, Daisuke Ogawa, Hirofumi Makino

    Diabetes   61 ( 4 )   897 - 907   2012.4

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    Inflammatory process is involved in the pathogenesis of diabetic nephropathy. In this article, we show that cholecystokinin (CCK) is expressed in the kidney and exerts renoprotective effects through its anti-inflammatory actions. DNA microarray showed that CCK was upregulated in the kidney of diabetic wild-type (WT) mice but not in diabetic intracellular adhesion molecule-1 knockout mice. We induced diabetes in CCK-1 receptor (CCK-1R) and CCK-2R double-knockout (CCK-1R(-/-),-2R(-/-)) mice, and furthermore, we performed a bone marrow transplantation study using CCK-1R(-/-) mice to determine the role of CCK-1R on macrophages in the diabetic kidney. Diabetic CCK-1R(-/-),-2R(-/-) mice revealed enhanced albuminuria and inflammation in the kidney compared with diabetic WT mice. In addition, diabetic WT mice with CCK-1R(-/-) bone marrow-derived cells developed more albuminuria than diabetic CCK-1R(-/-) mice with WT bone marrow-derived cells. Administration of sulfated cholecystokinin octapeptide (CCK-8S) ameliorated albuminuria, podocyte loss, expression of proinflammatory genes, and infiltration of macrophages in the kidneys of diabetic rats. Furthermore, CCK-8S inhibited both expression of tumor necrosis factor-α and chemotaxis in cultured THP-1 cells. These results suggest that CCK suppresses the activation of macrophage and expression of proinflammatory genes in diabetic kidney. Our findings may provide a novel strategy of therapy for the early stage of diabetic nephropathy.

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  • Calpain inhibition attenuates angiotensin II-induced abdominal aortic aneurysms and atherosclerosis in low-density lipoprotein receptor-deficient mice. Reviewed International journal

    Venkateswaran Subramanian, Haruhito A Uchida, Talha Ijaz, Jessica J Moorleghen, Deborah A Howatt, Anju Balakrishnan

    Journal of cardiovascular pharmacology   59 ( 1 )   66 - 76   2012.1

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    Chronic infusion of angiotensin II (AngII) augments atherosclerosis and abdominal aortic aneurysm (AAA) formation in hypercholesterolemic mice. AngII-induced AAAs are associated with medial macrophage accumulation and matrix metalloproteinase (MMP) activation. Inhibition of calpain, a calcium-activated neutral cysteine protease, by overexpression of its endogenous inhibitor, calpastatin, attenuates AngII-induced leukocyte infiltration, perivascular inflammation, and MMP activation in mice. The purpose of this study was to define whether pharmacological inhibition of calpain influences AngII-induced AAAs in hypercholesterolemic mice. Male low-density lipoprotein receptor-/- mice were fed a fat-enriched diet and administered with either vehicle or a calpain-specific inhibitor, BDA-410 (30 mg/kg per day) for 5 weeks. After 1 week of feeding, mice were infused with AngII (1000 ng/kg per minute) for 4 weeks. AngII-infusion profoundly increased aortic calpain protein and activity. BDA-410 administration had no effect on plasma cholesterol concentrations or AngII-increased systolic blood pressure. Calpain inhibition significantly attenuated AngII-induced AAA formation and atherosclerosis development. BDA-410 administration attenuated activation of MMP12, proinflammatory cytokines (IL-6, monocyte chemoattractant protein-1), and macrophage infiltration into the aorta. BDA-410 administration significantly attenuated thioglycolate-elicited macrophage accumulation in the peritoneal cavity. We conclude that calpain inhibition using BDA-410 attenuated AngII-induced AAA formation and atherosclerosis development in low-density lipoprotein receptor-/- mice.

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  • Losartan/hydrochlorothiazide combination therapy surpasses high-dose angiotensin receptor blocker in the reduction of morning home blood pressure in patients with morning hypertension. Reviewed

    Yoshihisa Hanayama, Haruhito Adam Uchida, Yoshio Nakamura, Hirofumi Makino

    Acta medica Okayama   66 ( 6 )   449 - 59   2012

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    Angiotensin receptor blockers (ARBs) are the first-line antihypertensive agents. In clinical practice, it is often difficult to achieve the recommended blood pressure level by ARBs in their ordinal dosages alone. This study examined the practical efficacy of a combination therapy of ARB with thiazide diuretics for lowering morning home blood pressure (MHBP) in comparison to high-dose ARB therapy in patients with morning hypertension administered an ordinal dosage of ARB. This study was performed in a prospective, randomized, open-labeled and blind-endpoint fashion. Patients were considered to have morning hypertension when their self-measured systolic MHBPs were 135mmHg or higher, irrespective of their diastolic MHBP and office blood pressures (OBPs). Forty-eight outpatients with morning hypertension receiving the ordinal dosage of ARB were given either losartan/hydrochlorothiazide (n = 26) or high-dose ARB (n = 22) in place of their previously prescribed ARB. No change in any medication was permitted during this period. Decreases of both systolic and diastolic MHBP after 3 months of treatment were significantly greater in the losartan/hydrochlorothiazide group than in the high-dose ARB group (p < 0.05, respectively). The ratio of adverse events was somewhat high (23.1% in the losartan/hydrochlorothiazide group, 9.1% in the high-dose ARB group, respectively). However, there were no significant differences in any particular adverse event between groups. This study suggested losartan/hydrochlorothiazide might be superior to high-dose ARB for reducing morning home blood pressure.

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  • Urokinase-type plasminogen activator deficiency in bone marrow-derived cells augments rupture of angiotensin II-induced abdominal aortic aneurysms. Reviewed International journal

    Haruhito A Uchida, Aruna Poduri, Venkateswaran Subramanian, Lisa A Cassis, Alan Daugherty

    Arteriosclerosis, thrombosis, and vascular biology   31 ( 12 )   2845 - 52   2011.12

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    OBJECTIVE: Abdominal aortic aneurysms (AAAs) are associated with fragmentation of extracellular matrix during development of aortic dilation and rupture. Therefore, it is important to identify specific protease systems involved in extracellular matrix degradation during AAA formation. The present study determined the contribution of the urokinase system to AAA formation and rupture. METHODS AND RESULTS: Angiotensin II (Ang II)-induced AAAs were associated with increased aortic abundance of both urokinase-type plasminogen activator receptor (uPAR) and urokinase-type plasminogen activator (uPA) proteins. However, this increased presence was unrelated to AAA formation because deficiencies of either uPAR or uPA had no effect on either the incidence or size of Ang II-induced AAAs in both normolipidemic mice and low-density lipoprotein receptor-/- mice fed a saturated fat-enriched diet. Although uPA deficiency did not affect development of AAAs, there was an effect of increasing mortality rate from AAA rupture in hypercholesterolemic mice. Bone marrow transplantation demonstrated that enhanced aneurysmal rupture was attributable to deficiency of uPA in leukocytes. uPA deficiency led to an increased propensity for impaired resolution of the thrombotic material within the aneurysmal tissue. Neither uPAR nor uPA deficiency had any effect on Ang II-induced atherosclerosis in low-density lipoprotein receptor-/- mice. CONCLUSIONS: The uPA-uPAR axis has no effect on the formation of Ang II-induced AAAs, but uPA deficiency promotes aneurysmal rupture.

    DOI: 10.1161/ATVBAHA.111.234997

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  • Development of angiotensin II-induced abdominal aortic aneurysms is independent of catalase in mice. Reviewed International journal

    Haruhito A Uchida, Hitoshi Sugiyama, Keiichi Takiue, Yoko Kikumoto, Tatsuyuki Inoue, Hirofumi Makino

    Journal of cardiovascular pharmacology   58 ( 6 )   633 - 8   2011.12

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    Chronic infusion of angiotensin II (AngII) into mice augments the development of abdominal aortic aneurysms (AAAs). Catalase is an important antioxidant enzyme in cellular peroxisome, and it physiologically maintains tissue and cellular redox homeostasis and thus plays a central role in defense against oxidative stress. The purpose of this study was to define whether deficiency of catalase influences AngII-induced AAAs. Male acatalasemic (C3H/AnLCsCs) mice and wild-type (C3H/AnLCsCs) mice (8-12 weeks old, N = 24 and 25, respectively) were fed a normal chow for 5 weeks. After 1 week of acclimtion, mice were infused subcutaneously with AngII (1000 ng·kg·min) by osmotic minipumps for 4 weeks. AngII increased systolic blood pressure equivalently in both groups. Acatalasemia had no effect on serum cholesterol concentrations. The body weight of acatalasemic mice was slightly greater than that of wild-type mice (P = 0.008). Although aortic catalase activity in acatalasemic mice was significantly low (P < 0.001), acatalasemia had no significant effect on the incidence of AngII-induced AAA formation (acatalasemia, 23%; wild, 21%), ex vivo measurement of maximal diameter of abdominal aorta (acatalasemia, 1.22 ± 0.29 mm; wild, 1.21 ± 0.17 mm), or aortic deposition of lipid peroxidation products such as 4-hydroxy-2-nonenal. The development of AngII-induced AAAs is independent of catalase.

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  • 膜性増殖性糸球体腎炎と低γグロブリン血症の経過中に巣状糸球体硬化症を併発した1例

    辻 憲二, 内田 治仁, 小野 哲一郎, 喜多村 真治, 前島 洋平, 杉山 斉, 槇野 博史

    日本腎臓学会誌   53 ( 6 )   822 - 822   2011.8

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  • 気腫性胆嚢炎を発症した統合失調症合併糖尿病の一例

    内田 治仁, 四方 賢一, 小川 愛由, 篠浦 歩, 横道 直佑, 八木 孝仁, 小川 大輔, 佐藤 千景, 和田 淳, 梶谷 展生, 槇野 博史

    糖尿病   54 ( 4 )   316 - 316   2011.4

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  • Serum high-sensitivity cardiac troponin T is a significant biomarker of left-ventricular diastolic dysfunction in subjects with non-diabetic chronic kidney disease. Reviewed International journal

    Masashi Kitagawa, Hitoshi Sugiyama, Hiroshi Morinaga, Tatsuyuki Inoue, Keiichi Takiue, Yoko Kikumoto, Haruhito Adam Uchida, Shinji Kitamura, Yohei Maeshima, Norihisa Toh, Kazufumi Nakamura, Hiroshi Ito, Hirofumi Makino

    Nephron extra   1 ( 1 )   166 - 77   2011.1

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    BACKGROUND: Chronic kidney disease (CKD) is associated with left-ventricular (LV) diastolic dysfunction (LVDD) which progresses to diastolic heart failure. However, biomarkers predicting LVDD in patients with CKD are largely unknown. METHODS: In 93 patients with non-diabetic CKD, the relationships among echocardiography, high-sensitivity cardiac troponin T (hs-cTnT), B-type natriuretic peptide (BNP), and renal function were evaluated. LV mass index, peak early diastolic mitral filling velocity (E), peak early diastolic mitral annular velocity (E'), and E/E' were recorded. RESULTS: The E' values were significantly decreased and E/E', BNP, and hs-cTnT increased with increasing CKD stage. The CKD patients with LVDD with E' <5 cm/s had a significantly higher hs-cTnT level as well as a significantly higher BNP level compared to those with E' ≥5 cm/s. The area under the receiver-operating characteristic curve for hs-cTnT and BNP to detect E' <5 cm/s was 0.880 (p = 0.0101) and 0.741 (p = 0.0570), respectively. In multivariate analysis, hs-cTnT and albuminuria were significantly associated with E', and estimated glomerular filtration rate with the hs-cTnT level, after adjusting for age, cause of CKD, and other parameters. CONCLUSIONS: These data suggest that hs-cTnT may be a useful biomarker of LVDD in non- diabetic CKD patients.

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  • Insufficient control of morning home blood pressure in Japanese patients with hypertension associated with diabetes mellitus. Reviewed

    Haruhito A Uchida, Yoshio Nakamura, Hisanao Norii, Masanobu Kaihara, Yoshihisa Hanayama, Ken-Ei Sada, Jun Wada, Kenichi Shikata, Hirofumi Makino

    Journal of diabetes investigation   1 ( 6 )   266 - 72   2010.12

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    UNLABELLED: Aims/Introduction:  The combination of hypertension with diabetes mellitus (DM) has been recognized as a critical risk factor for cardiovascular disease (CVD). We investigated the blood pressure levels in hypertensive patients with DM (HDM patients) compared with those without DM (HnDM patients). Furthermore, we examined the effect of risk factors, including chronic kidney disease (CKD) and stroke, on the management of both office blood pressure (OBP) and morning home blood pressure (MHBP). MATERIALS AND METHODS:   OBP and MHBP were evaluated in 1230 essential hypertensive patients in 30 institutions. Among them, 366 (30%) were complicated with DM. RESULTS:   The ratio of masked hypertensives whose systolic OBP was <140 mmHg and systolic MHBP was more than 135 mmHg in HDM patients was significantly higher than that in HnDM patients (P < 0.02). HDM patients had significantly lower systolic and diastolic OBP and diastolic MHBP than HnDM patients (P < 0.05, respectively). However, systolic MHBP in HDM patients tended to be higher compared with HnDM patients (P = 0.0623). A stratified analysis showed that HDM patients with CKD or stroke had significantly higher systolic MHBP than others (P < 0.05, respectively). The adjusted odds ratio for morning hypertension defined by a systolic MHBP more than 135 mmHg was significantly higher in the HDM patients with CKD (1.98) compared with HnDM patients without CKD (reference). CONCLUSIONS:   Diabetes, CKD and stroke are risk factors for MHBP. More intensive treatment is needed to achieve the thera-peutic goal for systolic MHBP in HDM patients, especially those who are complicated with CKD or stroke. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2010.00056.x, 2010).

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  • Total lymphocyte deficiency attenuates AngII-induced atherosclerosis in males but not abdominal aortic aneurysms in apoE deficient mice. Reviewed International journal

    Haruhito A Uchida, Fjoralba Kristo, Debra L Rateri, Hong Lu, Richard Charnigo, Lisa A Cassis, Alan Daugherty

    Atherosclerosis   211 ( 2 )   399 - 403   2010.8

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    OBJECTIVE: T and B lymphocytes are associated with atherosclerosis and aneurysms. Angiotensin II (AngII) infusion into hypercholesterolemic mice results in augmentation of atherosclerosis and abdominal aortic aneurysm (AAA) formation. In this study, we determined whether total lymphocyte deficiency reduced AngII-induced vascular diseases. METHODS AND RESULTS: ApoE deficient (apoE -/-) mice were cross-bred with recombination activating gene-1 (Rag-1) deficient mice that lack mature T and B lymphocytes. Heterozygous littermates (Rag-1 +/-) have normal lymphocytic function and served as controls. Male and female apoE -/- mice that were either Rag-1 +/- or -/- were fed a normal laboratory diet and infused with either saline or AngII (1000ng/kg/min) subcutaneously via osmotic mini pump for 28 days. Total lymphocyte deficiency had no significant effect on body weight and systolic blood pressure prior to and during AngII infusion. However, it was associated with decreased serum cholesterol concentrations. AngII infusion increased atherosclerotic lesion area in Rag-1 +/- mice compared to saline (P=0.017 in males and P=0.004 in females). This effect was significantly blunted in Rag-1 -/- male (P=0.044), but not female mice. AngII-infusion promoted increased width of the abdominal aorta, with a greater effect in males. Despite the reduction in atherosclerosis in males, Rag-1 deficiency had no significant effect on AngII-induced aortic dilation in either gender. CONCLUSION: T and B lymphocyte deficiency attenuates AngII-induced atherosclerosis in males but not AAA formation in apoE -/- mice.

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  • Olmesartan and temocapril prevented the development of hyperglycemia and the deterioration of pancreatic islet morphology in Otsuka-Long-Evans-Tokushima Fatty rats. Reviewed

    Masanobu Kaihara, Yoshio Nakamura, Taro Sugimoto, Haruhito A Uchida, Hisanao Norii, Hisanao Norii, Yoshihisa Hanayama, Hirofumi Makino

    Acta medica Okayama   63 ( 1 )   35 - 42   2009.2

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    We investigated the impact of olmesartan and temocapril on pancreatic islet beta-cells during the development of diabetes mellitus using Otsuka-Long-Evans-Tokushima Fatty (OLETF) rats. Four-week-old male OLETF rats were fed standard chow (untreated:n5), or chow containing either 0.005% olmesartan(n5) or 0.01% temocapril (n5) until being sacrificed at 35 weeks of age. Pancreas sections were double-stained with anti-insulin and anti-glucagon antibodies. The percent areas of beta-cells, alpha-cells and non-alpha-non-beta-cells were compared among groups. In untreated OLETF rats, the fasting plasma glucose (FPG) level was elevated at the 18th week and remained elevated until the 35th week. On the other hand, no significant elevation in FPG levels was observed in olmesartan- or temocapril-treated rats. Pancreatic islets from olmesartan-treated rats were significantly smaller in size as compared with those from untreated OLETF rats. Furthermore, the average area occupied by beta-cells as a fraction of the total area of an individual islet was significantly higher in olmesartan- or temocapril-treated rats than that in untreated OLETF rats. Olmesartan and temocapril both prevented the development of hyperglycemia, possibly through the prevention of islet beta-cell loss in spontaneously diabetic OLETF rats.

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  • The MUSCAT study: a Multicenter PROBE Study Comparing the Effects of Angiotensin II Type-1 Receptor Blockers on Self-Monitored Home Blood Pressure in Patients with Morning Hypertension: study design and background characteristics. Reviewed International journal

    Haruhito Uchida, Yoshio Nakamura, Masanobu Kaihara, Hisanao Norii, Yoshihisa Hanayama, Hirofumi Makino

    Hypertension research : official journal of the Japanese Society of Hypertension   31 ( 1 )   51 - 8   2008.1

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    Elevated morning home blood pressure (MHBP) has been reported to have a close relationship to cerebro-cardiovascular events and hypertensive target organ damages, and hence is regarded as a predictor of cardiovascular events. However, there is no evidence that lowering of MHBP can improve morbidity, mortality or target organ damage. In recent guidelines, angiotensin II type-1 receptor blockers (ARBs) are recommended as the first-choice drugs for antihypertensive therapy. Pharmacological characteristics differ among ARBs, and some are suggested to have greater efficacy in lowering MHBP than others. In preparation for the MUSCAT study, we surveyed both self-monitored MHBP and office blood pressure (OBP) in 1,234 patients with essential hypertension. Among them, 367 patients had diabetes mellitus (DM) and 229 suffered from chronic kidney disease (CKD). More than 64% (n=790) of patients had morning hypertension. In MUSCAT, we will investigate the different effects of four ARBs (losartan, candesartan, valsartan, and telmisartan) in patients with morning hypertension, with a focus on the drugs' MHBP-lowering efficiency. Secondly, we will evaluate the different actions of the four ARBs on cardiovascular surrogate markers, such as the brachial-ankle pulse wave velocity, high-sensitive C-reactive protein level, and urinary albumin excretion/creatinine ratio. Patients will be randomized into four arms, and given one of the four "sartans" once daily for 12 months. MHBPs and surrogate markers will be examined at baseline and after 1 year of follow-up. In the stratified analysis, we will determine the significance of MHBP reduction on cardiovascular risk management.

    DOI: 10.1291/hypres.31.51

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  • Enhanced TGF-beta/Smad signaling in the early stage of diabetic nephropathy is independent of the AT1a receptor. Reviewed

    Yuko Okazaki, Yasushi Yamasaki, Haruhito A Uchida, Kazunori Okamoto, Minoru Satoh, Keisuke Maruyama, Yohei Maeshima, Hitoshi Sugiyama, Takeshi Sugaya, Naoki Kashihara, Hirofumi Makino

    Clinical and experimental nephrology   11 ( 1 )   77 - 87   2007.3

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    BACKGROUND: Angiotensin II (AII) and transforming growth factor-beta (TGF-beta) are closely involved in the pathogenesis of diabetic nephropathy (DN). AII is known to induce TGF-beta production in resident renal cells, including glomerular mesangial cells and tubular epithelial cells. TGF-beta receptor types I and II (TGF-betaRI, II) are up-regulated in the diabetic kidney. The aim of this study was to clarify the role of AII in the regulation of the TGF-beta system in the early stage of DN using AII type1a receptor-deficient(AT1a(-/-)) mice. METHODS: We investigated the expression of TGF-beta1, TGF-betaRI, II, and Smad signaling in AT1a(-/-) mice with streptozotocin (STZ)-induced DN. Mice were killed 10 and 20 days after the induction of hyperglycemia. The expression of TGF-beta receptors was analyzed by immunohistochemical staining and reverse transcriptase-polymerase chain reaction (RT-PCR). TGF-beta-specific Smad signaling was analyzed by electrophoretic mobility shift assay and Western blotting. RESULTS: The expression of both TGF-betaRI and RII was up-regulated in the glomerular tufts and vasculature in diabetic AT1a(+/+) mice kidney by immunohistochemistry. RT-PCR revealed that mRNAs for TGF-betaRI and RII were also up-regulated. Smad2 and 4 protein levels were reduced in the renal cortex after the induction of diabetes, with an increase of Smad 3/4 complex in the nucleus. The expression of TGF-beta receptors increased in both diabetic AT1a(-/-) and AT1a(+/+) mice. Smad signaling in AT1a(-/-) mice was also enhanced. CONCLUSIONS: Our results suggest that the complete blockade of the AT1a-mediated pathway has a minimal effect on the enhanced TGF-beta/Smad signaling in the early stage of DN, at least in the AT1a(-/-) model.

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  • Steroid pulse therapy impaired endothelial function while increasing plasma high molecule adiponectin concentration in patients with IgA nephropathy. Reviewed International journal

    Haruhito Adam Uchida, Yoshio Nakamura, Masanobu Kaihara, Hisanao Norii, Yoshihisa Hanayama, Hitoshi Sugiyama, Yohei Maeshima, Yasushi Yamasaki, Hirofumi Makino

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association   21 ( 12 )   3475 - 80   2006.12

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    BACKGROUND: Decreased plasma adiponectin is associated with impaired endothelial function and, thereby, increased risk for cardiovascular events. Glucocorticoid (GC) affects vascular endothelial cells either favourably or harmfully depending upon the dosages and duration. We examined the effect of GC pulse therapy on vascular endothelial function. METHODS: Fourteen young patients with IgA nephropathy were evaluated for flow-mediated vasodilation (FMD), plasma levels of adiponectin both in high molecular weight (HMW adiponectin) form and in single molecular form (total adiponectin), hepatocyte growth factor (HGF), asymmetric dimethylarginine (ADMA), and high-sensitive C-reactive protein, before and after a course of GC pulse therapy. RESULTS: GC pulse therapy significantly decreased FMD (from 7.2 +/- 2.6 to 5.7 +/- 2.5%, P < 0.01). Meanwhile, plasma adiponectin levels were significantly augmented (total adiponectin: from 10.2 +/- 4.0 to 12.1 +/- 6.3 microg/ml, P < 0.05; HMW: from 6.5 +/- 3.2 to 7.7 +/- 3.3 microg/ml, P < 0.05). In parallel, elevated concentrations of serum HGF (from 0.28 +/- 0.12 to 0.63 +/- 0.38 ng/ml, P < 0.01) and plasma ADMA (from 0.45 +/- 0.07 to 0.53 +/- 0.04 nmol/ml, P < 0.05) were observed. CONCLUSIONS: GC pulse therapy impaired endothelial function while increasing plasma adiponectin levels, which may in turn restore the endothelial function in patients with IgA nephropathy.

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  • An elderly patient with severe acute renal failure due to sodium bromate intoxication. Reviewed

    Haruhito A Uchida, Hitoshi Sugiyama, Sadahide Kanehisa, Kazushi Harada, Kenta Fujiwara, Tetsuya Ono, Michio Yamakido, Hirofumi Makino

    Internal medicine (Tokyo, Japan)   45 ( 3 )   151 - 4   2006

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    Accidental or deliberate ingestion of bromate solution has been reported in pediatric as well as adult cases; however there have been no reports of such intoxication in the elderly. We report a 78-year-old woman who suffered severe acute renal failure due to the accidental ingestion of sodium bromate solution. The patient was successfully treated with hemodialysis therapy and renal function recovered without hearing loss. This case suggests that emergency therapeutic measures, including hemodialysis, should be taken as soon as possible, and the rapid removal of bromate is essential to prevent severe intoxication and its sequelae. To the best of our knowledge this is the first report of an elderly patient that demonstrates the clinical benefit of hemodialysis therapy for bromate intoxication.

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  • Practical efficacy of telmisartan for decreasing morning home blood pressure and pulse wave velocity in patients with mild-to-moderate hypertension. Reviewed International journal

    Haruhito Uchida, Yoshio Nakamura, Masanobu Kaihara, Taro Sugimoto, Hisanori Norii, Motofumi Sasaki, Hajime Sato, Hirofumi Makino

    Hypertension research : official journal of the Japanese Society of Hypertension   27 ( 8 )   545 - 50   2004.8

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    The current guideline-recommended blood pressure values are difficult to maintain in general practice, partly due to the lack of ideal anti-hypertensive agents. Since morning hypertension has a high correlation with cardiovascular events, expectations that telmisartan, a long-acting angiotensin-II type-1 receptor blocker (ARB), can improve cardiovascular mortality are high. In this study, the efficiency of telmisartan in reducing morning hypertension and pulse wave velocity (PWV) as a practical surrogate endpoint was investigated. Seventeen unsupervised and 7 untreated hypertensive patients were prescribed telmisartan 40 mg/day for 3 months. Medication already prescribed upon enrollment in this study was continued, with the exception of ARBs (all of which turned out to be losartan 50 mg/day), which were discontinued and replaced with telmisartan. Morning home blood pressure (MHBP), office blood pressure (OBP), and brachial-ankle PWV (baPWV) were investigated in a prospective fashion. A stratified analysis was performed regarding previous use (group L) or non-use (group N) of losartan. Over a 3-month period, telmisartan was found to significantly reduce both OBP (from 153+/-13/85+/-9 to 141+/-17/80+/-7 mmHg (p <0.01)) and MHBP (from 153+/-23/93+/-11 to 137+/-22/82+/-10 mmHg (p <0.001)). Surprisingly, 7 patients (70%) from group L achieved an OBP of less than 140/90 mmHg by simply changing their medication to telmisartan. Furthermore, baPWV fell significantly from 1,892+/-334 cm/s to 1,672+/-324 cm/s (p <0.01), which was greater than the change in baPWV estimated by OBP reduction. Here it must be mentioned that there were no significant differences between group L and group N in the courses of blood pressures and baPWV. In conclusion, telmisartan 40 mg/day was found to be effective for reducing MHBP and arterial wall stiffness in patients with mild-to-moderate hypertension, and thus may also be effective for improving cerebrocardiovascular mortality.

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  • Pelvic lymphocyst infection associated with maternally inherited diabetes mellitus. Reviewed International journal

    Daisuke Ogawa, Kenichi Shikata, Mitsuhiro Matsuda, Jun Wada, Haruhito Uchida, Maki Asada, Hirofumi Makino

    Diabetes research and clinical practice   61 ( 2 )   137 - 41   2003.8

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    A 45-year-old woman with 20-year history of diabetes mellitus was admitted to our hospital because of high fever and abdominal pain. Radical hysterectomy and bilateral pelvic lymphadenectomy had been performed 4 months before admission for invasive cervical cancer. On admission, elastic hard tumors were palpable in the lower abdomen. Laboratory examination showed positive C-reactive protein (CRP), anemia and renal dysfunction. Computed tomography (CT) revealed several lymphocysts in the pelvis. She was diagnosed with infection of pelvic lymphocysts. Since her mother also had diabetes associated with deafness, we examined mitochondrial DNA in leukocytes and detected an A to G transition at the nucleotide position of 3243 (A3243G mutation). She was diagnosed as maternally inherited diabetes mellitus and deafness (MIDD). Puncture of the cysts followed by administration of antibiotics resulted in marked improvement of symptoms and laboratory findings. This is a rare case of pelvic lymphocyst infection in a patient with a mitochondrial disorder. Although the exact mechanism of infection is not clear, MIDD may represent an unusual risk factor for infection, and further investigation is necessary to assess the influence of mitochondrial dysfunction on the immune system. Pelvic lymphocyst infection should be considered in the differential diagnosis of abdominal pain and fever in patients with MIDD after abdominal surgery.

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  • 【血管炎の診断と治療:エッセンスと今後の展望】各種血管炎の診断・鑑別診断と治療 高安動脈炎

    内田 治仁

    診断と治療   109 ( 10 )   1385 - 1391   2021.10

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    <Headline>1 高安動脈炎は大型血管炎の代表的疾患の1つであり、日本人に多い。2 診断のためには、まず疑うことが大切である。症状は多彩でかつ非特異であるため丁寧な診察、詳細な問診そして画像診断が最も重要である。これらにより近年は早期診断が可能となってきている。3 治療は、炎症抑制目的に副腎皮質ホルモンを中心とした免疫抑制療法が行われることが多いが、炎症鎮静化後も血管病変による症状により日常生活が制限される患者も少なくないため、多角的な観点での治療を心掛けるべきである。(著者抄録)

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  • THE IMPACT OF BLOOD PRESSURE MANAGEMENT IN PATIENTS WITH CHRONIC KIDNEY DISEASE: A MULTICENTER PROSPECTIVE COHORT STUDY IN JAPAN

    Mariko Nishiwaki, Haruhito A. Uchida, Nozomu Otaka, Yoshiko Hada, Yasuhiro Onishi, Natsumi Uchiyama, Shugo Okamoto, Rika Takemoto, Masashi Kitagawa, Hitoshi Sugiyama, Chie Saito, Kunihiro Yamagata, Jun Wada

    JOURNAL OF HYPERTENSION   39   E122 - E123   2021.4

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  • The disease subsets in giant cell arteritis: data from an international observational cohort (Diagnostic and Classification Criteria in Vasculitis Study-DCVAS).

    大西康博, 内田治仁

    月刊リウマチ科   65 ( 1 )   2021

  • 中四国地域におけるCKDおよびCVDの関連に関するコホート研究;Kakusyo3C Studyのイベント解析

    大高望, 内田治仁, 竹内英実, 辻憲二, 田邊克幸, 木野村賢, 吉田賢司, 前島洋平, 杉山斉, 伊藤浩, 和田淳

    日本腎臓学会誌(Web)   63 ( 4 )   2021

  • 甲状腺機能低下症とCKDの関連性におけるCr代謝の影響についての検討

    内山奈津実, 辻憲二, 喜多村真治, 稲垣兼一, 内田治仁, 杉山斉, 和田淳

    日本腎臓学会誌(Web)   63 ( 4 )   2021

  • 慢性腎臓病における貧血管理~Kakusyo3C Studyからの検討

    奥山由加, 内田治仁, 大高望, 竹内英実, 辻憲二, 田邊克幸, 木野村賢, 吉田賢司, 前島洋平, 杉山斉, 伊藤浩, 和田淳

    日本腎臓学会誌(Web)   63 ( 4 )   2021

  • 岡山市CKDネットワーク(OCKD-NET)におけるCKD病診連携10年後の追跡調査

    大西康博, 内田治仁, 大高望, 竹内英実, 辻憲二, 田邊克幸, 森永裕士, 木野村賢, 喜多村真治, 前島洋平, 杉山斉, 太田康介, 丸山啓輔, 大城義之, 森岡茂, 瀧上慶一, 蒲生直幸, 和田淳

    日本腎臓学会誌(Web)   63 ( 4 )   2021

  • 地域医療連携

    内田 治仁

    岡山医学会雑誌   132 ( 2 )   108 - 109   2020.8

  • 【血管炎症候群を理解する】診る 大型血管炎をいかに診断するか?

    内田 治仁

    Heart View   24 ( 8 )   687 - 692   2020.8

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    <文献概要>Point 1 多枝の狭窄病変や拡張病変,著明な石灰化など,通常と異なる画像をみたら第一に疑う。2 造影CT,造影MRI,FDG-PET,血管超音波などの画像診断が重要である。3 特徴的な症状,原因不明の発熱や炎症反応高値などがある場合,本疾患を疑う。

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J03097&link_issn=&doc_id=20200717160004&doc_link_id=%2Fap4heard%2F2020%2F002408%2F003%2F0687-0692%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fap4heard%2F2020%2F002408%2F003%2F0687-0692%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

  • 腎臓病を克服する-腎臓病対策の全国展開と地域での活動 NPO法人日本腎臓病協会の取り組みの現状

    伊藤 孝史, 内田 治仁, 柏原 直樹

    日本腎臓学会誌   62 ( 4 )   216 - 216   2020.7

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  • 腎臓病を克服する-腎臓病対策の全国展開と地域での活動 NPO法人日本腎臓病協会の取り組みの現状

    伊藤 孝史, 内田 治仁, 柏原 直樹

    日本腎臓学会誌   62 ( 4 )   2020.7

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  • 【腎疾患領域の臨床研究の展望】産官学連携臨床研究の展望(KRI-Jの可能性について)

    伊藤 孝史, 内田 治仁, 南学 正臣, 柏原 直樹

    腎臓内科   11 ( 6 )   622 - 627   2020.6

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  • Clinical Significance of Total Vascular Resistance, Augmention Index and Augmentation Pressure in Patients With Peripheral Artery Disease

    Rika Takemoto, Haruhito A. Uchida, Nozomu Otaka, Shugo Okamoto, Mariko Nishiwaki, Yasuhiro Onishi, Natsumi Matsuoka, Yoshiko Hada, Hironobu Toda, Fumio Otsuka, Hiroshi Ito, Jun Wada

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   40   2020.5

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  • Inhibition of Interleukin-6 Signaling Attenuates Aortitis and Cardiomyocyte Hypertrophy in Interleukin-1 Receptor Antagonist Deficient Mice

    Yoshiko Hada, Haruhito A. Uchida, Tomoyuki Mukai, Fumiaki Kojima, Nozomu Otaka, Hidemi Takeuchi, Masashi Yoshida, Yoshitaka Morita, Jun Wada

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   40   2020.5

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  • 中四国地域におけるCKDおよびCVDの関連に関する前向きコホート研究;Kakusyo3C Study:登録3年後の中間解析

    大高望, 内田治仁, 西脇麻里子, 辻憲二, 北川正史, 田邊克幸, 木野村賢, 吉田賢司, 前島洋平, 杉山斉, 伊藤浩, 和田淳

    日本腎臓学会誌(Web)   62 ( 4 )   2020

  • 中四国地域におけるCKDおよびCVDの関連に関するコホート研究Kakusyo3C Study:登録3年後のCKD管理状況

    西脇麻里子, 内田治仁, 大高望, 辻憲二, 北川正史, 田邊克幸, 木野村賢, 吉田賢司, 前島洋平, 杉山斉, 伊藤浩, 和田淳

    日本腎臓学会誌(Web)   62 ( 4 )   2020

  • 腎不全療法選択説明が緊急透析導入と療法選択に与える影響

    森永裕士, 笠原由美子, 井本紀子, 角川紫野, 矢田光子, 大高望, 辻憲二, 北川正史, 田邊克幸, 木野村賢, 喜多村真治, 内田治仁, 杉山斉, 和田淳

    日本透析医学会雑誌   53 ( Supplement 1 )   2020

  • 岡山市CKDネットワーク(OCKD-NET)におけるCKD病診連携9年後の追跡調査

    大西康博, 内田治仁, 大高望, 辻憲二, 田邊克幸, 森永裕士, 木野村賢, 喜多村真治, 前島洋平, 杉山斉, 太田康介, 丸山啓輔, 大城義之, 森岡茂, 大森一慶, 瀧上慶一, 蒲生直幸, 和田淳

    日本腎臓学会誌(Web)   62 ( 4 )   2020

  • 慢性腎臓病における貧血管理~Kakusyo3C Studyからの検討

    内山奈津実, 内田治仁, 西脇麻里子, 大高望, 辻憲二, 北川正史, 田邊克幸, 木野村賢, 吉田賢司, 前島洋平, 杉山斉, 伊藤浩, 和田淳

    日本腎臓学会誌(Web)   62 ( 4 )   2020

  • JAK阻害薬による血管炎治療の可能性

    内田 治仁, 松本 佳則

    リウマチ科   62 ( 5 )   451 - 456   2019.11

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  • JKA活動 JKAの活動報告

    伊藤 孝史, 内田 治仁, 柏原 直樹

    日本腎臓学会誌   61 ( 8 )   1155 - 1159   2019.11

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  • Long-term Clinical Course and Outcomes of 2013 Patients with Takayasu Arteritis

    Hajime Yoshifuji, Haruhito Uchida, Yoshikazu Nakaoka, Takahiko Sugihara, Mitsuaki Isobe, Masayoshi Harigai

    ARTHRITIS & RHEUMATOLOGY   71   2019.10

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  • チーム医療・地域医療としての腎疾患対策 CKD地域連携の実際 岡山県におけるCKD対策

    内田 治仁

    日本腎臓学会誌   61 ( 6 )   861 - 861   2019.8

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  • Inhibition of Interleukin-6 Signaling on Aortitis in Interleukin-1 Receptor Antagonist Deficient Mice

    Yoshiko Hada, Haruhito A. Uchida, Tomoyuki Mukai, Fumiaki Kojima, Nozomu Otaka, Yasuhiro Onishi, Yoshitaka Morita, Yoichiro Iwakura, Jun Wada

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   39   2019.5

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  • Exogenous Vasohibin-2 Influences Development of Angiotensin II-induced Ascending Aortic Aneurysms but Not Abdominal Aortic Aneurysms in Either Normolipidemic or Apolipoprotein E-Deficient Mice

    Nozomu Otaka, Haruhito A. Uchida, MIchihiro Okuyama, Yuki Kakio, Yoshiko Hada, Hidemi Takeuchi, Ryoko Umebayashi, Katsuyuki Tanabe, Yasufumi Sato, Jun Wada

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   39   2019.5

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  • CKD対策の新たな展開 NPO法人日本腎臓病協会の役割

    伊藤 孝史, 内田 治仁, 柏原 直樹

    日本腎臓学会誌   61 ( 3 )   228 - 228   2019.5

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  • Total Vascular Resistance and Augmentation Pressure in Patients with Peripheral Artery Disease

    Rika Takemoto, Haruhito A. Uchida, Nozomu Otaka, Yoshiko Hada, Yasuhiro Onishi, Natsumi Matsuoka, Shugo Okamoto, Mariko Nishiwaki, Hironobu Toda, Fumio Otsuka, Hiroshi Ito, Jun Wada

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   39   2019.5

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  • 【CKD対策の最新動向】CKD診療体制・連携について

    内田 治仁, 前島 洋平, 杉山 斉, 和田 淳, 槇野 博史

    日本腎臓学会誌   61 ( 2 )   81 - 85   2019.3

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  • 【腎臓・高血圧診療・研究のアップデート】日本腎臓病協会設立の目的と展望 腎臓病の克服を目指して

    柏原 直樹, 伊藤 孝史, 内田 治仁, 要 伸也

    循環器内科   85 ( 1 )   4 - 10   2019.1

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  • 中四国地域におけるCKDおよびCVDの関連に関するコホート研究;Kakusyo 3C Study:登録2年後の中間解析

    大高望, 内田治仁, 大西章史, 辻憲二, 北川正史, 田邊克幸, 木野村賢, 吉田賢司, 前島洋平, 杉山斉, 伊藤浩, 和田淳

    日本腎臓学会誌   61 ( 3 )   2019

  • 慢性腎臓病における貧血管理~Kakusyo 3C Studyからの検討

    松岡奈津実, 内田治仁, 大高望, 大西章史, 辻憲二, 北川正史, 田邊克幸, 木野村賢, 吉田賢司, 前島洋平, 杉山斉, 伊藤浩, 和田淳

    日本腎臓学会誌   61 ( 3 )   2019

  • 中四国地域におけるCKDおよびCVDの関連に関するコホート研究Kakusyo 3C Study:登録2年後のCKD管理状況

    西脇麻里子, 内田治仁, 大高望, 大西章史, 辻憲二, 北川正史, 田邊克幸, 木野村賢, 吉田賢司, 前島洋平, 杉山斉, 伊藤浩, 和田淳

    日本腎臓学会誌   61 ( 3 )   2019

  • Characteristics and Treatment Outcomes of Takayasu Arteritis in a Nationwide, Retrospective Cohort Study in Japan

    Haruhito A. Uchida, Yoshikazu Nakaoka, Hajime Yoshifuji, Takahiko Sugihara, Yoshiko Watanabe, Masayoshi Harigai, Yoshihiro Arimura, Mitsuaki Isobe

    ARTHRITIS & RHEUMATOLOGY   70   2018.9

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  • Exogenous Vasohibin-2 Does Not Influence Angiotensin II-induced Abdominal Aortic Aneurysms Formation in Either Normolipidemic or Apolipoprotein E-Deficient Mice

    Nozomu Otaka, Haruhito A. Uchida, Yoshiko Hada, Hidemi Takeuchi, Yuki Kakio, MIchihiro Okuyama, Ryoko Umebayashi, Katsuyuki Tanabe, Yasufumi Sato, Jun Wada

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   38   2018.5

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    DOI: 10.1161/atvb.38.suppl_1.110

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  • 非アルコール性脂肪肝疾患を有する高血圧患者においてオルメサルタンは肝機能および肝線維化マーカー(TGF-β1)を改善させる

    大高 望, 内田 治仁, 梅林 亮子, 大西 康博, 奥山 由加, 竹内 英実, 垣尾 勇樹, 杉山 斉, 近藤 文雄, 原田 一志, 則井 久尚, 岡崎 祐子, 杉本 太郎, 橋本 洋夫, 和田 淳

    Therapeutic Research   39 ( 2 )   159 - 166   2018.2

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    非アルコール性脂肪肝疾患を有する高血圧患者11例(男性6例、女性5例、平均年齢59歳)を対象にオルメサルタン20mgを1日1回朝食後に12週間内服投与し、その効果を検討した。オルメサルタン投与前後で外来時の拡張期・収縮期血圧はいずれも有意な低下を認めた。また、肝機能およびTGF-β1は投与後に有意な改善を認めた。以上より、オルメサルタンは高血圧患者における降圧効果を示すだけでなく、非アルコール性脂肪肝障害の改善効果を有することが示唆された。

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  • Olmesartan ameliorates hepatic insufficiency and serum TGF-β1 level in hypertensive patients with non-alcoholic fatty liver disease

    Nozomu Otaka, Haruhito A. Uchida, Ryoko Umebayashi, Yasuhiro Onishi, Yuka Okuyama, Hidemi Takeuchi, Yuki Kakio, Hitoshi Sugiyama, Fumio Kondo, Kazushi Harada, Hisanao Norii, Yuko Okazaki, Taro Sugimoto, Hiroo Hashimoto, Jun Wada

    Therapeutic Research   39 ( 2 )   159 - 166   2018

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    © 2018 Excerpta Medica Inc. All rights reserved. Background : Because of westernization of lifestyle in recent years, the number of patients with lifestyle diseases, including obesity, metabolic syndrome, hypertension, dyslipidemia and diabetes mellitus, are increasing steadily. Recently, it has been noted that non-alcoholic fatty liver disease (NAFLD) alone can cause liver cirrhosis or liver cancer. Angiotensin type II receptor blocker (ARB) is widely used in clinical practice as an antihypertensive agent. In addition to the antihypertensive effect by inhibiting the renin-angiotensin system, ARB has been demonstrated to protect the multiple organs damage, including brain, heart and kidney. In recent years, many reports suggest that the renin-angiotensin system is involved in the development of liver fïbrosis. Objectives : We examined the protective effect of olmesartan on hepatic insufficiency and hepatic fibrosis marker in hypertensive patients with NAFLD. Methods : Olmesartan was administered to eleven hypertensive patients with NAFLD for 12 weeks. Results : Both office systolic blood pressure and diastolic blood pressure decreased from 141±3/82±2 mmHg to 130±7/76±4 mmHg (p = 0.035). AST decreased significantly from 48.8±4.5 IU/L to 42.2±4.6 IU/L (p=0.011), AST from 7l.7±7.8 IU/L to 59.8±8.5IU/L (p = 0.046), y-GTP from 102.3±21.6 IU/L to 90±20.3 IU/L (p = 0.049). Finally, regarding TGF β1, a significant change was observed from 14898±3101 pg/mL to 10738±2405pg/mL (p = 0.017). Conclusions: Olmesartan ameliorates hepatic insufficiency in hypertensive patients with NAFLD. Olmesartan may not only have a class effect of ARB but also have a drug effect, especially on NAFLD.

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  • 珪肺に続発したループス腎炎の1例

    福島和彦, 内田治仁, 御舩朋代, 渊本康子, 和田大広, 大西章史, 北川正史, 田邊克幸, 木野村賢, 喜多村真治, 小崎晋司, 杉山斉, 金廣有彦, 岸本卓巳, 和田淳

    日本腎臓学会誌   60 ( 6 )   2018

  • 【高齢者のCKD-保存期から透析まで-】CKDとフレイル

    竹内 英実, 内田 治仁, 和田 淳

    Geriatric Medicine   55 ( 12 )   1335 - 1340   2017.12

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    フレイルは加齢に伴って身体的予備力の低下した状態で、要支援・要介護の前段階、あるいは健康と身体機能障害の中間にある状態である。一方で、CKDは加齢に伴いその頻度は増加し、高齢者の多いわが国においては8人に1人がCKD患者であると推定されている国民病である。CKD患者は一般高齢者に比べフレイルを合併しやすく、合併することで透析導入や死亡のリスクを増大させる。CKDとフレイルは相互に悪影響を及ぼし合うこともわかっており、超高齢化を迎えたわが国において、今後フレイルを合併した予後不良のCKD患者は間違いなく増加するであろう。フレイルの最大の特徴は改善可能という点であり、早期に発見し、適切に対応することが望まれる。(著者抄録)

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  • 【肺血管炎の基礎と臨床】高安動脈炎における肺血管病変

    内田 治仁, 和田 淳

    呼吸器内科   32 ( 4 )   354 - 359   2017.10

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  • Characteristics and Treatment Outcomes of Giant Cell Arteritis with Large-Vessel Lesions in a Nationwide, Retrospective Cohort Study in Japan

    Takahiko Sugihara, Hitoshi Hasegawa, Haruhito Uchida, Hajime Yoshifuji, Yoshikazu Nakaoka, Yoshiko Watanabe, Eisuke Amiya, Masanori Konishi, Yasuhiro Katsumata, Yoshinori Komagata, Taio Naniwa, Takahiro Okazaki, Yoshiya Tanaka, Tsutomu Takeuchi, Masayoshi Harigai, Yoshihiro Arimura, Mitsuaki Isobe

    ARTHRITIS & RHEUMATOLOGY   69   2017.10

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  • Vasohibin-2は大動脈瘤モデルマウスにおいてVEGFとは独立して胸部大動脈瘤を増悪させる

    奥山 倫弘, 内田 治仁, 垣尾 勇樹, 梅林 亮子, 田邊 克幸, 藤井 泰宏, 大澤 晋, 佐藤 靖史, 和田 淳

    脈管学   57 ( Suppl. )   S128 - S128   2017.10

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  • 抗血管内皮細胞増殖因子(VEGF)薬硝子体内注射による腎障害が示唆された糖尿病性腎症の1例

    大高 望, 川北 智英子, 木野村 賢, 北川 正史, 田邊 克幸, 江口 潤, 内田 治仁, 杉山 斉, 和田 淳, 清水 章

    日本腎臓学会誌   59 ( 6 )   731 - 731   2017.9

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  • 岡山県健診受診者の慢性腎臓病(CKD)認知度 2015年度

    内田 治仁, 杉山 斉, 宮崎 雅史, 和田 淳, 四方 賢一, 柏原 直樹, 槇野 博史

    岡山医学会雑誌   129 ( 2 )   101 - 105   2017.8

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    岡山県では、2012年度から「第2次地域医療再生計画における糖尿病等生活習慣病医療連携推進事業」の中でCKD対策専門部会を設置し、同部会を中心にCKD対策に取り組んできた。これまで実施してきた対策のうち重要な取り組みのひとつとして、一般住民に対する啓蒙活動が挙げられる。今回、これまでの啓蒙活動により「CKD」「慢性腎臓病」という言葉が県民全体にどの程度認知されているのか把握するため、2015年10月〜11月に県下5医療圏12施設で健診を受けた人のうち協力が得られた7022名にアンケートを行った。結果、CKDの認知度は「知っている」と答えた人が4%、「聞いたことはある」が10%、「知らない」が85%であり、慢性腎臓病の認知度は「知っている」27%、「聞いたことはある」38%、「知らない」36%であった。医療圏別で比較したところ、CKDの認知度は県北部の圏域で高い傾向にあり、慢性腎臓病の認知度についても同様であった。

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  • 脂質異常症(高LDL血症、高TG血症、低HDL血症)の薬物療法について、治療薬の選択について教えてください。(研修1年7ヵ月)

    内田 治仁

    岡山医学会雑誌   129 ( 2 )   129 - 130   2017.8

  • 降圧薬使用の最適化に対する薬学的介入 降圧薬の処方実態からみえてきたチーム医療における薬学的介入の可能性

    神崎 浩孝, 有木 沙織, 竹内 英実, 小川 敦, 西原 茂樹, 村川 公央, 北村 佳久, 内田 治仁, 和田 淳, 千堂 年昭

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   6回   151 - 151   2017.5

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  • 高血圧治療ガイドライン改訂による降圧薬処方動向の変化

    有木 沙織, 神崎 浩孝, 竹内 英実, 小川 敦, 西原 茂樹, 村川 公央, 北村 佳久, 内田 治仁, 和田 淳, 千堂 年昭

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   6回   167 - 167   2017.5

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  • Overexpression of Vasohibin-2 Exacerbates Development of Angiotensin II-Induced Thoracic Aortic Aneurysms Independent of VeEGF

    Michihiro Okuyama, Haruhito A. Uchida, Ryoko Umebayashi, Yuki Kakio, Hidemi Takeuchi, Katsuyuki Tanabe, Yasufumi Sato, Jun Wada

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   37   2017.5

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  • RECENT CLINICAL FEATURE OF THE PATIENTS WITH TAKAYASU ARTERITIS IN A NATIONWIDE, RETROSPECTIVE COHORT STUDY IN JAPAN

    Haruhito A. Uchida, Yoshikazu Nakaoka, Hajime Yoshifuji, Takehiko Sugihara, Yoshiko Watanabe, Hitoshi Hasegawa, Eisuke Amiya, Masanori Konishi, Yoshihiro Arimura, Mitsuaki Isobe

    RHEUMATOLOGY   56   43 - 43   2017.3

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  • CHARACTERISTICS OF PATIENTS WITH GIANT CELL ARTERITIS AND TAKAYASU ARTERITIS IN A NATIONWIDE, RETROSPECTIVE COHORT STUDY IN JAPAN

    Takahiko Sugihara, Hitoshi Hasegawa, Haruhito Uchida, Hajime Yoshifuji, Yoshikazu Nakaoka, Yoshiko Watanabe, Kazuo Tanemoto, Eisuke Amiya, Masanori Konishi, Yoshihiro Arimura, Mitsuaki Isobe

    RHEUMATOLOGY   56   52 - 52   2017.3

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  • 抗てんかん薬の長期内服中に緩徐進行性の腎機能低下を呈した1例

    御舩朋代, 田邊克幸, 川北智英子, 山成俊夫, 北川正史, 木野村賢, 内田治仁, 喜多村真治, 杉山斉, 和田淳

    日本腎臓学会誌   59 ( 6 )   2017

  • 梅井論文に対するEditorial Comment

    竹内 英実, 内田 治仁

    心臓   48 ( 4 )   455 - 455   2016.4

  • 岡山県糖尿病医科・歯科連携で用いられる「歯周病セルフチェック票」の妥当性についての検討

    天田 雅文, 利根 淳仁, 角南 次郎, 大森 一弘, 松尾 敬子, 出原 陽子, 原本 麻代, 伊勢田 泉, 内田 治仁, 四方 賢一, 高柴 正悟, 肥田 和之, 和田 淳

    Diabetes Frontier   26 ( 4 )   512 - 517   2015.8

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    「歯周病セルフチェック票(以下セ票)」の妥当性を検討する目的で、2型糖尿病患者156名を対象に、セ票(全11項目、計21点)に記入後、歯科検診を実施した。検診評価項目として残存歯数、プラークスコア、歯肉炎指数、歯周ポケット深さを用いた。合計点数4点以下(罹患の可能性小)が32名、5〜9点(罹患の可能性大)が66名、10点以上(重度罹患の可能性大)が58名で、歯周ポケットの最大深度および全歯周ポケットに対する4mm以上の歯周ポケット深さが占める割合は、10点以上の群で他の2群より有意に高値を示した。セ票10点以上は、糖尿病患者における歯周病スクリーニングに有用であると考えられた。(著者抄録)

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  • クローン病に合併したIgA腎症の1例

    寺坂 友博, 内田 治仁, 梅林 亮子, 塚本 啓子, 田中 景子, 北川 正史, 杉山 斉, 和田 淳, 谷岡 洋亮

    日本腎臓学会誌   57 ( 6 )   1126 - 1126   2015.8

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  • 【他疾患を持つ患者さんの看護ケア-糖尿病・認知症・CKD・がん-】CKDは心臓病患者の生命予後を悪化させる

    内田 治仁

    循環器ナーシング   5 ( 7 )   46 - 54   2015.7

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    <point>●慢性腎臓病(CKD)は、日本に約1330万人いるといわれる国民病である!●CKDは、心血管疾患(CVD)イベントを起こす危険因子である!●CKDの早期発見・早期治療が心血管イベント予防に大切である!(著者抄録)

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  • 【腎臓病療養指導とチーム医療】総合的CKD対策の現状 地域医療連携室のかかわりによる腎臓病療養指導の拡がり

    内田 治仁

    日本腎臓学会誌   57 ( 5 )   828 - 832   2015.7

  • 【2型糖尿病におけるmultimorbidity】2型糖尿病×高血圧×慢性腎臓病

    梅林 亮子, 内田 治仁, 槇野 博史

    薬局   66 ( 7 )   2164 - 2170   2015.6

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    <Key Points>2型糖尿病と高血圧は高率に合併し、高血圧は糖尿病による腎障害をさらに悪化させる。糖尿病に対する集学的治療により糖尿病性腎症による透析導入患者の割合は2010年以降横ばいに転じたが、糖尿病性腎症は依然として透析導入原因疾患の第1位である。糖尿病性腎症では腎症の進展とともに大血管障害の合併リスクが高くなる。厳格な血糖コントロールと厳格な血圧コントロールにより、糖尿病性腎症の発症抑制、腎症のregression(退縮)、remission(寛解)が得られる。腎症3期以降では、食事療法の内容の変更と腎機能の応じた降圧薬・血糖降下薬の選択が必要になる。食事療法、運動療法、薬物療法を組み合わせて、血圧、血糖のみならず、肥満、脂質異常症などの危険因子を管理することが重要である。(著者抄録)

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  • 複数の側副血行路を有する腎血管性高血圧症に逆行性腎静脈塞栓術が有用であった1例

    梅林 亮子, 内田 治仁, 寺坂 友博, 塚本 啓子, 垣尾 勇樹, 竹内 英実, 奥山 由加, 北川 正史, 藤原 寛康, 金澤 右, 杉山 斉, 和田 淳

    日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   4回   142 - 142   2015.5

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  • 多発性嚢胞腎における指定難病重症度分類の評価に関する検討

    大西章史, 杉山斉, 田中景子, 山成俊夫, 秋山愛由, 北川正史, 森永裕士, 井上達之, 菊本陽子, 田邊克幸, 木野村賢, 花山宣久, 内田治仁, 喜多村真治, 和田淳

    日本腎臓学会誌   57 ( 3 )   2015

  • 糖尿病の腎臓においてcholecystokininはマクロファージに対する抗炎症作用を介した新規の保護効果を発揮する

    宮本 聡, 四方 賢一, 宮坂 京子, 岡田 震一, 佐々木 基史, 小寺 亮, 廣田 大昌, 梶谷 展生, 高塚 哲全, 片岡 仁美, 西下 伸吾, 堀口 千景, 船越 顕博, 西森 久和, 内田 治仁, 小川 大輔, 槇野 博史

    岡山医学会雑誌   126 ( 1 )   1 - 6   2014.4

  • 慢性腎臓病合併高血圧患者におけるアジルサルタンの臨床的効果の検討

    奥山 由加, 内田 治仁, 花山 宜久, 勅使川原 早苗, 梅林 亮子, 北川 正史, 杉山 斉, 槇野 博史

    Therapeutic Research   35 ( 3 )   293 - 298   2014.3

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    Language:Japanese   Publisher:ライフサイエンス出版(株)  

    対象は年齢20歳以上85歳未満で、慢性腎臓病を有する高血圧患者のうち、アジルサルタン以外のアンジオテンシンII受容体拮抗薬(ARB)常用量を含む降圧薬にて、3ヵ月以上加療してもなお、降圧目標に到達していない患者(男性9例、女性5例、年齢62±13歳)で、アジルサルタンの降圧効果、腎機能および血管内皮機能への影響について検討を行った。その結果、アジルサルタン20mg投与前後の外来収縮期血圧は有意に低下し、腎機能に関しての変化は、随時尿の総蛋白/クレアチニン比の有意な減少が認められた。血管内皮機能に関しては、反応性充血指数(RHI)が登録時1.8未満と低値であった8症例で検討したところ、有意な改善が認められた。各種マーカーや脂質プロファイルの変化においては、MDA-LDL、PAI-1、hsCRPでは、いずれも有意な変化を認めず、脂質においても有意な変化は認められなかった。以上の結果より、慢性腎臓病を合併する高血圧患者において、投与中のARBをアジルサルタンへ切り替えることで、さらなる降圧作用が示され、比較的安全に投与できる可能性が示唆された。

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    Other Link: https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2014&ichushi_jid=J01759&link_issn=&doc_id=20140403120014&doc_link_id=issn%3D0289-8020%26volume%3D35%26issue%3D3%26spage%3D293&url=http%3A%2F%2Fwww.pieronline.jp%2Fopenurl%3Fissn%3D0289-8020%26volume%3D35%26issue%3D3%26spage%3D293&type=PierOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00005_2.gif

  • 降圧療法により改善をみた悪性高血圧に伴う腎障害を来した2例

    荒田夕佳, 北川正史, 垣尾勇樹, 加藤綾子, 山成俊夫, 田邊克幸, 森永裕士, 内田治仁, 喜多村真治, 前島洋平, 杉山斉, 和田淳

    日本腎臓学会誌   56 ( 6 )   2014

  • 慢性腎臓病におけるエピジェネティクスと酸化ストレスの関連に関する検討

    大西章史, 杉山斉, 山成俊夫, 小川愛由, 北川正史, 森永裕士, 菊本陽子, 田邊克幸, 内田治仁, 喜多村真治, 前島洋平, 槇野博史

    日本腎臓学会誌   56 ( 3 )   2014

  • HD併用療法の実態調査 アンケート集計結果とPDR-CSレジストリから

    森永 裕士, 杉山 斉, 山成 俊夫, 小川 愛由, 北川 正史, 瀧上 慶一, 菊本 陽子, 内田 治仁, 喜多村 真治, 赤木 滋, 前島 洋平, 槇野 博史

    腎と透析   75 ( 別冊 腹膜透析2013 )   161 - 162   2013.7

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    Language:Japanese   Publisher:(株)東京医学社  

    岡山大学病院と関連施設における2011年6月から1年間のHD併用療法の実態についてアンケート調査した。11施設からPD患者212例についての回答が得られ、HD併用療法施行例の割合は15.1%であった。2009年から新潟大学・名古屋大学・九州大学・岡山大学で運営している多施設合同PDレジストリ(PDR-CS)の2011年度集計では、HD併用療法施行例の割合は4.8%であり、当院関連施設はこれと比較してはるかに高い普及率であった。

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  • 【冠動脈疾患診療(心血管イベント二次予防)】糖尿病、慢性腎臓病について循環器内科医が考えるべきこと

    内田 治仁, 槇野 博史

    Cardiac Practice   24 ( 2 )   145 - 149   2013.5

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  • 末期腎不全患者への治療法選択説明に関する実態調査

    森永裕士, 杉山斉, 山成俊夫, 小川愛由, 北川正史, 菊本陽子, 内田治仁, 喜多村真治, 赤木滋, 前島洋平, 槇野博史

    日本透析医学会雑誌   46 ( Supplement 1 )   2013

  • 岡山市CKDネットワーク(OCKD-NET)におけるCKD病診連携2年後の追跡調査

    山崎浩子, 前島洋平, 喜多村真治, 内田治仁, 赤木滋, 杉山斉, 太田康介, 平松信, 大城義之, 森岡茂, 福島正樹, 槇野博史

    日本腎臓学会誌   55 ( 3 )   2013

  • 尿中Trefoil Factor 3は慢性腎臓病における腎機能予後を予測するバイオマーカーである

    山成俊夫, 森永裕士, 杉山斉, 小川愛由, 北川正史, 菊本陽子, 内田治仁, 喜多村真治, 赤木滋, 前島洋平, 小川大輔, 四方賢一, 大本安一, 槇野博史

    日本腎臓学会誌   55 ( 3 )   2013

  • 生体肝移植後に発症したネフローゼ症候群の1例

    山成俊夫, 内田治仁, 勝山隆行, 当真貴志雄, 喜多村真治, 前島洋平, 杉山斉, 高取優二, 槇野博史

    日本腎臓学会誌   54 ( 6 )   2012

  • 尿中Na排泄過剰は女性CKD患者の尿蛋白・高血圧と相関し腎予後不良因子である

    森永裕士, 杉山斉, 小川愛由, 瀧上慶一, 北川正史, 菊本陽子, 内田治仁, 喜多村真治, 赤木滋, 前島洋平, 槇野博史

    日本腎臓学会誌   54 ( 3 )   2012

  • 慢性腎臓病患者における尿中Trefoil Factor 3は腎機能低下に伴い排泄増加し蛋白尿と相関する

    森永裕士, 杉山斉, 小川愛由, 瀧上慶一, 北川正史, 菊本陽子, 内田治仁, 喜多村真治, 赤木滋, 前島洋平, 大本安一, 小川大輔, 四方賢一, 槇野博史

    日本腎臓学会誌   54 ( 3 )   2012

  • 糖尿病性腎症におけるCholecystokininの抗炎症作用のメカニズム

    宮本聡, 四方賢一, 四方賢一, 宮坂京子, 小寺亮, 小寺亮, 廣田大昌, 梶谷展生, 佐藤千景, 佐藤千景, 片岡仁美, 片岡仁美, 小川大輔, 小川大輔, 内田治仁, 西森久和, 槇野博史

    日本糖尿病・肥満動物学会年次学術集会プログラム・講演抄録集   26th   2012

  • 【急性腎障害(AKI)の診療】各論-原因 コレステロール塞栓症とAKI

    内田 治仁, 槇野 博史

    Modern Physician   31 ( 1 )   53 - 56   2011.1

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    Language:Japanese   Publisher:(株)新興医学出版社  

    ●コレステロール塞栓症による腎障害は、粥状硬化巣がなんらかの原因で破綻し、コレステロール結晶が腎臓内の小動脈を閉塞することによって発症する。●血管手術後や心臓カテーテル検査後、あるいは抗凝固療法後に発症することが多い。●コレステロール塞栓は腎臓のみならず皮膚、腸管、脳などの多臓器に影響を及ぼす。●医原性要因、急性/亜急性腎障害、および皮膚症状の古典的3徴候のほか、好酸球の上昇が診断の手がかりとなる。●粥腫を安定化させるためスタチンの投与が推奨される。(著者抄録)

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  • IgA腎症に対するテルミサルタンの抗蛋白尿効果

    小林 みずほ, 杉山 斉, 内田 治仁, 角南 玲子, 小野田 哲也, 佐々木 基史, 来山 浩之, 山本 佳彦, 丸山 美江, 佐田 憲映, 和田 淳, 前島 洋平, 山崎 康司, 槇野 博史

    腎と透析   57 ( 4 )   537 - 542   2004.10

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    Language:Japanese   Publisher:(株)東京医学社  

    腎生検にてIgA腎症と確定診断された10症例(男性4例・女性6例,年齢41〜68歳・平均51.8±8.3歳)を対象にアンジオテンシンII受容体拮抗薬であるテルミサルタン投与による蛋白尿・血圧・腎機能に対する効果について検討した.対象患者にテルミサルタン1日1回10〜20mgより経口投与を開始し,血圧125/75mg以下を目標に投与量を漸増して臨床効果を前向きに検討した.その結果,テルミサルタンの投与により尿蛋白は投与開始前の2.11±1.52gから4ヵ月後より有意に低下し,6ヵ月後には0.54±0.12gと有意に低下した.開始前と6ヵ月後の血圧は収縮期が135.2±15.6mmHgから125.4±4.8mmHgに,拡張期が86.3±13.0mmHgから74.4±2.4mmHgに有意に低下した.投与中の血清クレアチニン値は開始2ヵ月後に軽度上昇したが,4ヵ月後には投与開始前のレベルに回復していた.以上より,テルミサルタンの投与により有意な尿蛋白の減少と降圧効果を認め,腎機能も維持され重篤な副作用も認めなかったことから短期的には有用と考えられた

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  • 下大静脈完全閉塞を合併した特発注門脈圧亢進症の1例(第82回日本循環器学会中国地方会)

    内田 治仁, 中村 好男, 則井 久尚, 開原 正展, 杉本 太郎, 槇野 博史, 三井 秀也

    Circulation journal : official journal of the Japanese Circulation Society   67   1009 - 1009   2003.10

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    CiNii Article

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  • シクロスポリン血中濃度に及ぼす抗真菌剤の影響 血漿交換を含めて

    川上 恭弘, 荒木 博陽, 橋本 泉, 内田 治仁, 杉山 斉, 山崎 康司, 五味田 裕, 槇野 博史

    TDM研究   20 ( 4 )   291 - 296   2003.10

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    Language:Japanese   Publisher:(一社)日本TDM学会  

    シクロスポリン(CyA)と抗真菌剤を同時投与された2例についてCyAの血中濃度と腎機能を中心に検討した.症例1ではCyAにイトラコナゾール(ITCZ)を併用することで血中CyAが急上昇し,又,アムホテリシンBの使用により腎機能が低下した.症例2でもITCZの併用により血中CyAが上昇し,ITCZからフルコナゾールに変更することでCyAは速やかに減少した.血漿交換を受けた症例1ではこれによる血中CyAへの明らかな影響は認められなかった

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  • 腎疾患における血管内皮機能の検討 2

    喜多村真治, 前島洋平, 中村好男, 内田治仁, 開原正展, 杉山斉, 山崎康司, 槙野博史

    日本腎臓学会誌   45 ( 3 )   2003

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Research Projects

  • Role of microsomal prostaglandin E synthase-1 in the development of psoriasis.

    Grant number:21K06603  2021.04 - 2024.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    小島 史章, 内田 治仁, 坂本 信一

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    Grant amount:\4160000 ( Direct expense: \3200000 、 Indirect expense:\960000 )

    本研究は、遺伝子改変マウスを用いてPGE2生合成系に起因する免疫系の制御に主眼をおいた乾癬の病態形成機構の解明を目的としている。本年度は、乾癬病態モデルを対象とした解析を行って、乾癬モデルマウスの病態にPGE2生合成系が寄与する可能性を示す結果を得た。また、二次リンパ組織である脾臓において、組織学的な変化が生じていることも見出し、免疫系の関与が推察された。

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  • N型カルシウムチャンネルが腹部大動脈瘤発症・進展に与える分子機構の解明

    Grant number:20K09127  2020.04 - 2023.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    内田 治仁

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    Grant amount:\4290000 ( Direct expense: \3300000 、 Indirect expense:\990000 )

    本研究では、腹部大動脈瘤の発症・進展におけるN型カルシウムチャンネルの意義について着目し、腹部大動脈瘤に対する新規治療法開発への足がかりとして、その重要性と分子機構を解明することを目的としている。
    本年度は、まず高脂血症モデルのN型カルシウムチャンネルノックアウトマウス作成を行った。N型カルシウムチャンネルノックアウトマウス(α1Bノックアウトマウス)とapoEノックアウトマウス(以下apoE KO)を入手・交配し、N型カルシウムチャンネル/apoEダブルノックアウトマウス(以下DKO)を作成した。
    次に、オス8~10週齢のDKOマウスとapoE KOマウスそれぞれに対してアンジオテンシンII(以下AngII、1,000ng/kg/min)あるいは生理食塩水を4週間、浸透圧ポンプを用いて投与した。生理食塩水を投与したマウスでは、体重、血圧、総コレステロール値、大動脈径などに関して群間で差は認められなかった(各N=5)。AngIIを投与したマウスについては、体重、血圧、総コレステロール値について群間で差は認められなかった。大動脈径については統計学的にわずかに有意でないものの、DKOマウスのほうで小さい傾向にあった。腹部大動脈瘤の発症率においても、統計学的にわずかに有意でないものの、DKOのほうで腹部大動脈瘤の発症抑制の傾向が認められた。免疫組織学的な検討においても、DKO群でapoE KO群と比べてマクロファージの病変部への浸潤が抑制されていることが確認された。

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  • 血管石灰化病変の退縮を目指した、骨細胞様細胞に着目した血管石灰化の病態解析

    Grant number:20K08875  2020.04 - 2023.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    藤田 俊一, 向井 知之, 内田 治仁, 小畑 淳史, 守田 吉孝, 金藤 秀明

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    Grant amount:\4290000 ( Direct expense: \3300000 、 Indirect expense:\990000 )

    炎症性サイトカインによる血管石灰化への影響を評価するため、マウス大動脈を組織を用いたex vivoでの大動脈培養実験を行った。マウスより大動脈を摘出し、石灰化誘導培地で培養した。その培養系に炎症性サイトカインとしてIL-1β、IL-6、IL-17Aを加え、石灰化に及ぼす影響をマイクロCTおよび組織染色にて評価した。結果、IL-17Aが大動脈の石灰化を濃度依存的に促進することが分かった。IL-1β、IL-6にも一部促進傾向が見られたが,統計学的有意差は認めなかった。
    本研究成果は、IL-17Aが血管石灰化の促進に働くことを示している。乾癬および乾癬性関節炎は、その病態にIL-17Aが強く関与することが知られている。本研究成果は、乾癬及び乾癬性関節炎患者において血管合併症リスクが増えることの機序の説明になると考える。また、本モデルは比較的簡便に血管石灰化を誘導できるモデルであり、本モデルを用いて治療候補薬剤の評価などにも用いることが出来ると考える。
    現在までの研究成果は、下記の論文として報告した。
    IL-17A promotes vascular calcification in an ex vivo murine aorta culture.
    Hiramatsu-Asano S, Mukai T, Akagi T, Uchida HA, Fujita S, Nakano K, Morita Y.
    Biochem Biophys Res Commun. 2022 May 14;604:83-87. doi: 10.1016/j.bbrc.2022.03.051. Epub 2022 Mar 10.

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  • Improvement of the patency rate for a small diameter vascular garft using Diamond-like-carbon coating

    Grant number:18K08733  2018.04 - 2021.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    MURAOKA GENYA

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    Grant amount:\4420000 ( Direct expense: \3400000 、 Indirect expense:\1020000 )

    When inner surface of ePTFE artificial vascular graft was coated with our new DLC-coating technology, the DLC-coated surface was more hydrophilic, more smooth, had more albumin and fibrinogen adsorption, and less platelets adhesion. With SDS-PAGE, protein adsorption was increased in almost all of category of protein molecule size. The whole blood test indicated that DLC has non-inferior hemocompatibility to normal ePTFE. As for an vascular graft function, DLC-coated ePTFE was non-inferior to normal ePTFE for hemocompatibility and patency in carotid artery replacement animal model using beagles. During this study, we newly developed carboxylated-DLC which is more hydrophilic than normal DLC and has started some studies about this new DLC with a new grant. In addition, during this study, we verified that this DLC can't be classified by current DLC classification because it has both DLC features and PLC features. This fact will be very historical in the field of DLC research.

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  • Development of DLC Coating Artificial Vascular Graft To Achieve Higher Patency

    Grant number:17K10756  2017.04 - 2020.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    FUJII YASUHIRO

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    Grant amount:\4550000 ( Direct expense: \3500000 、 Indirect expense:\1050000 )

    In this study, we have developed a novel technology of DLC coating for the inner side of ePTFE vascular graft. Then, we have got some patents for this technology. We proved that this new DLC coating improves hemocompatibility of ePTFE by reducing platelet adhesion, decreasing fibrinogen adsorption, and increasing albumin adsorption. Also, we performed arterial replacements in dogs and hemodyalysis shunt creations in goats. These studies proved that DLC coating ePTFE decreased hypertrophy of neointima after the graft implantation from the anastomosis sites.

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  • Molecular mechanism of Vasohibin-2 on development of abdominal aortic aneurysm

    Grant number:17K10757  2017.04 - 2020.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    UCHIDA HARUHITO

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    Grant amount:\4550000 ( Direct expense: \3500000 、 Indirect expense:\1050000 )

    The effect of Vasohibin-2, an angiogenesis regulator, on the development and progression of abdominal aortic aneurysm was fundamentally examined. When abdominal aortic aneurysm was induced in each of the mice in which Vasohibin-2 was overexpressed and the control mice, no significant difference was observed in the onset and progress of abdominal aortic aneurysm between the two groups. To confirm the result, protein expression was examined by histological and molecular biological approachs, but similarly no significant difference was observed between the two groups. Taken together, we found that Vasohibin-2 does not affect the development nor progression of abdominal aortic aneurysm.

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  • Effect and molecular mechanism of Vasohibin on development of abdominal aortic aneurysm

    Grant number:26462106  2014.04 - 2017.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    UCHIDA HARUHITO

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    Grant amount:\4940000 ( Direct expense: \3800000 、 Indirect expense:\1140000 )

    The role of Vasohibin-1 on development of Angiotensin II-inducced abdominal aortic aneurysm was examined. Angiotensin II of 1,000ng/kg/min was infused into male Vasohibin-1 +/- mice via osmotic mini-pump for 4 weeks, then abdominal aortic aneurysm was evaluated. Contrary to our expectation, hetero-knock out of Vasohibin-1 had minor effect on abdominal aortic aneurysm formation in comparison to control mice. In addition, no difference was observed between groups regarding several protease activities. This result implies that Vasohibin-1 plays little role on development of abdominal aortic aneurysm.

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  • The role of calpain on the development of abdominal aortic aneurysm

    Grant number:24791376  2012.04 - 2014.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    UCHIDA Haruhito

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    Grant amount:\4290000 ( Direct expense: \3300000 、 Indirect expense:\990000 )

    We examined the effect of calpain on the development of abdominal aortic aneurysm using AngII-infused apolipoprotein E deficient (apoE -/-) mice model.
    First, a calpain inhibitor significantly attenuated the formation of abdominal aortic aneurysm. On the other hand, calpain-1 deficiency in apoE -/- mice had no effect on the development of abdominal aortic aneurysm. Therefore, we found the significance of calpain on the development of abdominal aortic aneurysm however, it still remains unknown which isoform of calpain is important.

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  • Molecular mechanism of intercellular adhesion molecule-1 in the development of abdominal aortic aneurysms

    Grant number:22791252  2010 - 2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

    UCHIDA Haruhito

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    Grant amount:\4030000 ( Direct expense: \3100000 、 Indirect expense:\930000 )

    Angiotensin II was infused into apoE deficient mice(SKO) and ICAM-1xapoE double deficient mice(DKO) to develop abdominal aortic aneurysm(AAA). ICAM-1 deficiency in whole body attenuated the development of AAA. Bone marrow transplantation revealed that ICAM-1 deficiency in the recipient mice reduced the development of AAA. This result suggests that ICAM-1 may play an important role in the development of AAA formation in this model.

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  • Lecture: Myocardial Infarction (2023academic year) special  - その他

  • advanced medical sciences (2022academic year) Prophase  - 不開講

  • Lecture: Myocardial Infarction (2022academic year) special  - その他

  • advanced medical sciences (2021academic year) Prophase  - その他

  • Lecture: Myocardial Infarction (2021academic year) special  - その他