Updated on 2025/07/02

写真a

 
UCHIDA Haruhito
 
Organization
Scheduled update Special-Appointment Professor
Position
Special-Appointment Professor
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Degree

  • Doctor (MD, PhD) ( 2006.3   Okayama University )

Research Areas

  • Life Science / General internal medicine

Education

  • Okayama University   医学部大学院医学研究科  

    1999.4 - 2006.3

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    Country: Japan

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  • Okayama University   医学部   医学科

    1993.4 - 1999.3

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    Country: Japan

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Professional Memberships

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Papers

  • Performance of the modified 2022 ACR/EULAR giant cell arteritis classification criteria without age restriction for discriminating from Takayasu arteritis

    Takahiko Sugihara, Masayoshi Harigai, Haruhito A. Uchida, Hajime Yoshifuji, Yasuhiro Maejima, Jun Ishizaki, Yoshiko Watanabe, Hiroaki Dobashi, Yoshinori Komagata, Naoto Tamura, Yoshikazu Nakaoka, Yoshiya Tanaka, Tsutomu Takeuchi, Taio Naniwa, Hiroko Nagafuchi, Takahiro Okazaki, Tetsuya Horita, Tatsuya Atsumi, Yoshihiro Arimura, Mitsuaki Isobe, Kazuo Tanemoto, Noriyoshi Ogawa, Yohko Murakawa, Shunsuke Furuta, Hitoshi Hasegawa, Yasuhiro Katsumata, Eisuke Amiya, Hiroshi Akazawa, Issei Komuro, Koichi Amano, Atsushi Kawakami, Shigeto Kobayashi, Takashi Wada, Eri Muso, Atsushi Komatsuda, Satoshi Ito, Noriyuki Homma, Taichi Hayashi, Shinichi Takeda, Takashi Wada

    Arthritis Research & Therapy   27 ( 1 )   2025.1

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    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Abstract

    Objective

    To evaluate the ability to discriminate giant cell arteritis (GCA) from Takayasu arteritis (TAK) according to the modified 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology (ACR/EULAR) GCA classification criteria.

    Methods

    Patients enrolled in the Japanese nationwide retrospective registry were evaluated using the criteria with partial modification; wall thickening of descending thoracic-abdominal aorta were mainly diagnosed by contrast-enhanced computed tomography (CT) or magnetic resonance imaging instead of evaluating with positron emission tomography (PET)-CT. The discriminability of the criteria was evaluated using C-statistic (> 0.7: good ability).

    Results

    Newly diagnosed patients with GCA (n = 139) and TAK (n = 129) were assessed, and 23.3% of TAK were aged 50 years or older at onset. The sensitivity of the modified 2022 ACR/EULAR GCA classification criteria with a score ≥ 6 was 82.0%, 68.5%, and 32.1% in all GCA, GCA with large-vessel involvement, and GCA without cranial arteritis, respectively. The specificity of the modified criteria was 96.1% for the 129 TAK as controls. Five patients with late-onset TAK met the modified criteria, and four had cranial signs and symptoms, two had bilateral axillary artery involvement, and four had descending thoracic-abdominal aorta involvement. The discriminability of the criteria was good (C-statistic: 0.986, 95% confidence interval [CI]: 0.976–0.996) and remained good after excluding age (C-statistic: 0.927, 95% CI: 0.894–0.961). The discriminability of a set of large-vessel lesions (bilateral axillary artery and descending thoracic-abdominal aorta) and inflammatory markers was markedly decreased with poor C-statistic value (C-statistic: 0.598, 95% CI: 0.530–0.667). Discriminability was improved after adding polymyalgia rheumatica (PMR) (C-statistic: 0.757, 95% CI: 0.700–0.813) or age (C-statistic: 0.913, 95%CI: 0.874–0.951) to the set of large-vessel lesions. In GCA patients with a score ≤ 5, 52% had bilateral subclavian and/or axillary artery involvement.

    Conclusion

    The modified 2022 ACR/EULAR GCA classification criteria well performed in classifying GCA and TAK without PET-CT in routine clinical practice. A set of items included in the modified GCA classification criteria had good discriminative ability for GCA and TAK, even when age was excluded. However, age restriction or PMR was required to distinguish GCA without cranial lesions from TAK.

    DOI: 10.1186/s13075-025-03486-y

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    Other Link: https://link.springer.com/article/10.1186/s13075-025-03486-y/fulltext.html

  • The Change in Public Perception and Knowledge Acquisition Methods of Chronic Kidney Disease Among General Population in Okayama Prefecture, Japan. International journal

    Ryoko Umebayashi, Natsumi Matsuoka-Uchiyama, Hitoshi Sugiyama, Kenichi Shikata, Naoki Kashihara, Hirofumi Makino, Jun Wada, Haruhito A Uchida

    Diseases (Basel, Switzerland)   12 ( 11 )   2024.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    CKD public education plays a very important role in effective chronic kidney disease (CKD) countermeasure. We have been conducting CKD public education programs in Okayama Prefecture since 2007. Here, we aimed to examine the actual status of CKD perceptance and changes in CKD perceptance due to these education programs. The study was conducted on individuals who underwent health checkups at 12 medical institutions across five medical regions in Okayama Prefecture between 1 October and 30 November in 2015, 2019, and 2023. The results showed that overall CKD perceptance has improved over time (perceptance of "CKD" 4% to 7%, "chronic kidney disease" 27% to 34%, 2015 vs. 2023). "Chronic kidney disease" was more commonly recognized than "CKD", and the elderly were more aware of the disease than younger people. The CKD perceptance improved across all age groups. However, the rate of CKD perceptance is still low, especially among young people. Previously, newspapers were the second most common resource of information about CKD after television. However, the Internet has recently replaced newspapers as the second most common source of information, especially among younger people. Understanding of the exact diagnosis of CKD also remains insufficient. It is necessary to continue more effective CKD public education programs through more intelligible terminology and information sources that match the demographics of target population.

    DOI: 10.3390/diseases12110268

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  • Clinical Characteristics and Treatment Outcomes of Patients With Newly Diagnosed Takayasu Arteritis in Japan During the First 2 Years of Treatment ― A Nationwide Retrospective Cohort Study ―

    Haruhito A. Uchida, Yoshikazu Nakaoka, Takahiko Sugihara, Hajime Yoshifuji, Yasuhiro Maejima, Yoshiko Watanabe, Hiroko Nagafuchi, Takahiro Okazaki, Yoshinori Komagata, Yoshiya Tanaka, Eisuke Amiya, Tatsuya Atsumi, Kazuo Tanemoto, Tsutomu Takeuchi, Taio Naniwa, Atsushi Komatsuda, Hiroaki Dobashi, Koichi Amano, Noriyoshi Ogawa, Yohko Murakawa, Hitoshi Hasegawa, Taichi Hayashi, Yoshihiro Arimura, Mitsuaki Isobe, Masayoshi Harigai

    Circulation Journal   2024.9

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    Publishing type:Research paper (scientific journal)   Publisher:Japanese Circulation Society  

    DOI: 10.1253/circj.cj-24-0178

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  • A case of renal hypouricemia due to T217M mutation in SLC22A12 incidentally associated with IgA nephropathy. International journal

    Yoshimasa Sakurabu, Haruhito A Uchida, Toshihisa Tahara, Tomohiko Asakawa, Haruka Yamasaki, Katsuyoshi Katayama, Shugo Okamoto, Yasuhiro Onishi, Natsumi Matsuoka-Uchiyama, Keiko Tanaka, Hidemi Takeuchi, Kenji Tsuji, Ryoko Umebayashi, Yuki Ohashi, Kimiyoshi Ichida, Jun Wada

    Clinical case reports   12 ( 9 )   e9368   2024.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    A T217M heterozygous mutation in the SLC22A12 gene caused renal hypouricemia; this patient with IgA nephropathy had no findings other than IgA nephropathy on renal biopsy. Hypouricemia was susceptible to oxidative stress, but IgA nephropathy in the patient with hypouricemia could be treated with steroid pulse therapy without adverse events.

    DOI: 10.1002/ccr3.9368

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  • A case of membranous nephropathy complicated by Cronkhite-Canada syndrome successfully treated with mizoribine.

    Hiroyuki Nakanoh, Kenji Tsuji, Shiho Morimoto, Kazuhiko Fukushima, Masaya Iwamuro, Haruhito A Uchida, Jun Wada

    CEN case reports   2024.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    Cronkhite-Canada syndrome (CCS) is a non-hereditary disorder characterized by non-neoplastic hamartomatous gastrointestinal polyposis, hair loss, nail atrophy, hyperpigmentation, and diarrhea. While the relationship between CCS and nephritis remains unclear, seven cases of nephritis complicated by CCS have been reported to date, all of which were membranous nephropathy (MN). A 57-year-old man presented with taste disturbance, hair loss, nail plate atrophy, skin pigmentation, and frequent diarrhea. Endoscopic findings showed multiple polyposis of the stomach and large intestine. Given the above, he was diagnosed with CCS. The symptoms gradually improved with prednisolone treatment, although urinary protein and hypoproteinemia appeared during the tapering of prednisolone. He was diagnosed with MN using a renal biopsy, and immunofluorescence microscopy with IgG subclass staining showed predominantly diffuse granular capillary wall staining of IgG4. The cause of secondary MN was not found, including malignant tumors. Nephrotic-range proteinuria persisted despite treatment with prednisolone and cyclosporine. Additional treatment with mizoribine resulted in incomplete remission type 1 of nephrotic syndrome, suggesting that mizoribine may be a treatment option for patients with CCS with steroid-resistant MN. Considering a high prevalence of hypoproteinemia due to chronic diarrhea and protein-losing enteropathy in patients with CCS, proteinuria might be overlooked; thus, follow-up urinalysis would be recommended in patients with CCS.

    DOI: 10.1007/s13730-024-00908-9

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MISC

  • 平滑筋肉腫の両側腎臓への転移に対して両腎摘出術を契機に血液透析導入とした一例

    浅川知彦, 竹内英実, 岡本修吾, 大西康博, 田中景子, 辻憲二, 田邊克幸, 森永裕士, 内田治仁, 和田淳

    中国腎不全研究会誌   32   2024

  • 当院における非外傷性腹直筋血腫5症例の報告

    中納弘幸, 竹内英実, 森本志帆, 寺嶋悠也, 岡本修吾, 大西康博, 田中景子, 勝山隆行, 辻憲二, 田邊克幸, 森永裕士, 宇賀麻由, 冨田晃司, 平木隆夫, 内田治仁, 和田淳

    中国腎不全研究会誌   32   2024

  • Significant Association of Shared Decision Making on Predialysis Patients with Satisfied Modality Selection and Increased Quality of Life (QOL) After Dialysis

    Yasuhiro Onishi, Hiroshi Morinaga, Naoya Kobayashi, Tomoyo Morioka, Ichiro Nojima, Hidemi Takeuchi, Kenji Tsuji, Katsuyuki Tanabe, Haruhito A. Uchida, Hitoshi Sugiyama, Jun Wada

    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY   34 ( 11 )   1088 - 1088   2023.11

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:AMER SOC NEPHROLOGY  

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  • 【血管炎の診断と治療:エッセンスと今後の展望】各種血管炎の診断・鑑別診断と治療 高安動脈炎

    内田 治仁

    診断と治療   109 ( 10 )   1385 - 1391   2021.10

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    Language:Japanese   Publisher:(株)診断と治療社  

    <Headline>1 高安動脈炎は大型血管炎の代表的疾患の1つであり、日本人に多い。2 診断のためには、まず疑うことが大切である。症状は多彩でかつ非特異であるため丁寧な診察、詳細な問診そして画像診断が最も重要である。これらにより近年は早期診断が可能となってきている。3 治療は、炎症抑制目的に副腎皮質ホルモンを中心とした免疫抑制療法が行われることが多いが、炎症鎮静化後も血管病変による症状により日常生活が制限される患者も少なくないため、多角的な観点での治療を心掛けるべきである。(著者抄録)

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  • THE IMPACT OF BLOOD PRESSURE MANAGEMENT IN PATIENTS WITH CHRONIC KIDNEY DISEASE: A MULTICENTER PROSPECTIVE COHORT STUDY IN JAPAN

    Mariko Nishiwaki, Haruhito A. Uchida, Nozomu Otaka, Yoshiko Hada, Yasuhiro Onishi, Natsumi Uchiyama, Shugo Okamoto, Rika Takemoto, Masashi Kitagawa, Hitoshi Sugiyama, Chie Saito, Kunihiro Yamagata, Jun Wada

    JOURNAL OF HYPERTENSION   39   E122 - E123   2021.4

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    Language:English   Publishing type:Research paper, summary (international conference)   Publisher:LIPPINCOTT WILLIAMS & WILKINS  

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Research Projects

  • Role of microsomal prostaglandin E synthase-1 in the development of psoriasis.

    Grant number:21K06603  2021.04 - 2024.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    小島 史章, 内田 治仁, 坂本 信一

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    Grant amount:\4160000 ( Direct expense: \3200000 、 Indirect expense:\960000 )

    本研究は、遺伝子改変マウスを用いてPGE2生合成系に起因する免疫系の制御に主眼をおいた乾癬の病態形成機構の解明を目的としている。本年度は、乾癬病態モデルを対象とした解析を行って、乾癬モデルマウスの病態にPGE2生合成系が寄与する可能性を示す結果を得た。また、二次リンパ組織である脾臓において、組織学的な変化が生じていることも見出し、免疫系の関与が推察された。

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  • 血管石灰化病変の退縮を目指した、骨細胞様細胞に着目した血管石灰化の病態解析

    Grant number:20K08875  2020.04 - 2023.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    藤田 俊一, 向井 知之, 内田 治仁, 小畑 淳史, 守田 吉孝, 金藤 秀明

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    Grant amount:\4290000 ( Direct expense: \3300000 、 Indirect expense:\990000 )

    炎症性サイトカインによる血管石灰化への影響を評価するため、マウス大動脈を組織を用いたex vivoでの大動脈培養実験を行った。マウスより大動脈を摘出し、石灰化誘導培地で培養した。その培養系に炎症性サイトカインとしてIL-1β、IL-6、IL-17Aを加え、石灰化に及ぼす影響をマイクロCTおよび組織染色にて評価した。結果、IL-17Aが大動脈の石灰化を濃度依存的に促進することが分かった。IL-1β、IL-6にも一部促進傾向が見られたが,統計学的有意差は認めなかった。
    本研究成果は、IL-17Aが血管石灰化の促進に働くことを示している。乾癬および乾癬性関節炎は、その病態にIL-17Aが強く関与することが知られている。本研究成果は、乾癬及び乾癬性関節炎患者において血管合併症リスクが増えることの機序の説明になると考える。また、本モデルは比較的簡便に血管石灰化を誘導できるモデルであり、本モデルを用いて治療候補薬剤の評価などにも用いることが出来ると考える。
    現在までの研究成果は、下記の論文として報告した。
    IL-17A promotes vascular calcification in an ex vivo murine aorta culture.
    Hiramatsu-Asano S, Mukai T, Akagi T, Uchida HA, Fujita S, Nakano K, Morita Y.
    Biochem Biophys Res Commun. 2022 May 14;604:83-87. doi: 10.1016/j.bbrc.2022.03.051. Epub 2022 Mar 10.

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  • N型カルシウムチャンネルが腹部大動脈瘤発症・進展に与える分子機構の解明

    Grant number:20K09127  2020.04 - 2023.03

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    内田 治仁

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    Grant amount:\4290000 ( Direct expense: \3300000 、 Indirect expense:\990000 )

    本研究では、腹部大動脈瘤の発症・進展におけるN型カルシウムチャンネルの意義について着目し、腹部大動脈瘤に対する新規治療法開発への足がかりとして、その重要性と分子機構を解明することを目的としている。
    本年度は、まず高脂血症モデルのN型カルシウムチャンネルノックアウトマウス作成を行った。N型カルシウムチャンネルノックアウトマウス(α1Bノックアウトマウス)とapoEノックアウトマウス(以下apoE KO)を入手・交配し、N型カルシウムチャンネル/apoEダブルノックアウトマウス(以下DKO)を作成した。
    次に、オス8~10週齢のDKOマウスとapoE KOマウスそれぞれに対してアンジオテンシンII(以下AngII、1,000ng/kg/min)あるいは生理食塩水を4週間、浸透圧ポンプを用いて投与した。生理食塩水を投与したマウスでは、体重、血圧、総コレステロール値、大動脈径などに関して群間で差は認められなかった(各N=5)。AngIIを投与したマウスについては、体重、血圧、総コレステロール値について群間で差は認められなかった。大動脈径については統計学的にわずかに有意でないものの、DKOマウスのほうで小さい傾向にあった。腹部大動脈瘤の発症率においても、統計学的にわずかに有意でないものの、DKOのほうで腹部大動脈瘤の発症抑制の傾向が認められた。免疫組織学的な検討においても、DKO群でapoE KO群と比べてマクロファージの病変部への浸潤が抑制されていることが確認された。

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  • Improvement of the patency rate for a small diameter vascular garft using Diamond-like-carbon coating

    Grant number:18K08733  2018.04 - 2021.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    MURAOKA GENYA

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    Grant amount:\4420000 ( Direct expense: \3400000 、 Indirect expense:\1020000 )

    When inner surface of ePTFE artificial vascular graft was coated with our new DLC-coating technology, the DLC-coated surface was more hydrophilic, more smooth, had more albumin and fibrinogen adsorption, and less platelets adhesion. With SDS-PAGE, protein adsorption was increased in almost all of category of protein molecule size. The whole blood test indicated that DLC has non-inferior hemocompatibility to normal ePTFE. As for an vascular graft function, DLC-coated ePTFE was non-inferior to normal ePTFE for hemocompatibility and patency in carotid artery replacement animal model using beagles. During this study, we newly developed carboxylated-DLC which is more hydrophilic than normal DLC and has started some studies about this new DLC with a new grant. In addition, during this study, we verified that this DLC can't be classified by current DLC classification because it has both DLC features and PLC features. This fact will be very historical in the field of DLC research.

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  • Molecular mechanism of Vasohibin-2 on development of abdominal aortic aneurysm

    Grant number:17K10757  2017.04 - 2020.03

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    UCHIDA HARUHITO

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    Grant amount:\4550000 ( Direct expense: \3500000 、 Indirect expense:\1050000 )

    The effect of Vasohibin-2, an angiogenesis regulator, on the development and progression of abdominal aortic aneurysm was fundamentally examined. When abdominal aortic aneurysm was induced in each of the mice in which Vasohibin-2 was overexpressed and the control mice, no significant difference was observed in the onset and progress of abdominal aortic aneurysm between the two groups. To confirm the result, protein expression was examined by histological and molecular biological approachs, but similarly no significant difference was observed between the two groups. Taken together, we found that Vasohibin-2 does not affect the development nor progression of abdominal aortic aneurysm.

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Class subject in charge

  • Lecture: Myocardial Infarction (2024academic year) special  - その他

  • Lecture: Myocardial Infarction (2023academic year) special  - その他

  • advanced medical sciences (2022academic year) Prophase  - 不開講

  • Lecture: Myocardial Infarction (2022academic year) special  - その他

  • advanced medical sciences (2021academic year) Prophase  - その他

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