研究者詳細 - 佐々木　健二

MISC - 佐々木　健二

分割表示 111 件中 61 - 80 件目／全件表示 >>

Polycyclic N-Heterocyclic Compounds. 56. Reaction of N-(5,6-Dihydro[1]benzoxepino-[5,4-d]pyrimidin-4-yl)amidine or Its Amide Oxime Derivatives with Hydroxyl-amine Hyrdochloride

Kenji Sasaki, Ying-Xue Zhang, Kensuke Okuda, Takashi Hirota

J. Heterocyclic Chem. 2001年

Effects of 4-Hydroxyantipyrine and Acetaminophen O-Sulfate as Biodistribution Promoter

Yuhsuke Ohkawa, Yasunori Kiyohara, Tomoyuki Asoh, Hiroshi Maeda, Masateru Kurumi, Kenji Sasaki, Yuhji Kurosaki, Miki Matsumura, Taiji Nakayama

Biol. Pharm. Bull. 2001年

Effects of 4-Hydroxyantipyrine and Its 4-O-Sulfate on Antipyrine as Biodistribution Promoter

Yusuke Ohkawa, Miki Matsumura, Yuhji Kurosaki, Masateru Kurumi, Kenji Sasaki, Taiji Nakayama

Biol. Pharm. Bull. 2001年

Polycyclic N-Heterocyclic Compounds. 57. Syntheses of Fused Furo(or Thieno)[2,3-b]Pyridine Derivatives via Smiles Rearrangement and Intramolecular Cyclization

Takashi Hirota, Kei-ichiroh Tomita, Kenji Sasaki, Kensuke Okuda, Masahiko Yoshida, Setsuo Kashino

Heterocycles 2001年

Synthesis and Chemiluminescent Activity of 8,9-Dihydrobenzo[g]pyridazino[4,5-b]indole-7,10(11H)-diones

Masateru Kurumi, Kenji Sasaki, Hiroko Takata, Taiji Nakayama

J. Heterocyclic Chem. 2001年

Study on Glutathione-sulphonic Acid as Biodistribution Promoter: Concomitant Use Effect on Verapamil Hydrochloride and Tegafur.

Yusuke Ohkawa, Kyohko Higashiyama, Shigenari Sugaya, Tomoyuki Asoh, Hiroshi Maeda, Kenji Sasaki, Taiji Nakayama

Biol. Pharm. Bull. 2001年

Syntheses of Thiopyrone and Pyrone Derivatives by Photocyclization Reaction of 3-Aryl-2-([1]benzothien-3-yl)-propenoic Acids

Kenji Sasaki, Yasuyoshi Satoh, Takashi Hirota, Taiji Nakayama, Yoshinori Tominaga, nd Raymo, N. Castle

J. Heterocyclic Chem. 2000年

Synthesis and Chemiluminescent Activity of Pyridazino[4,5-b]indole-1,4- (2H,3H)-diones

Masateru Kurumi, Kenji Sasaki, Hiroko Takata, Taiji Nakayama

Heterocycles 2000年

Syntheses of thiopyrone and pyrone derivatives by photocyclization reaction of 3-aryl-2-([1]benzothien-3-yl)propenoic acids

Kenji Sasaki, Yasuyoshi Satoh, Takashi Hirota, Taiji Nakayama, Yoshinori Tominaga, Raymond N. Castle

Journal of Heterocyclic Chemistry 37 ( 4 ) 959 - 967 2000年

記述言語：英語

Naphtho[1, 2-b][1]benzothiophene-6-carboxylic acids, 6H-benzo[b]naphtho[2, 3-d]thiopyran-6-ones and 6H-benzo[b]naphtho[2, 3-d]pyran-6-ones were synthesized in one step by the photocyclization reaction of 3-aryl-2-([1]benzothien-3-yl)propenoic acids. The photocyclization reaction did not occur when the 3-aryl group contained the electron-withdrawing nitro group. The assignment of the 1H and 13C nmr spectra of 6H-benzo[b]naphtho[2, 3-d]thiopyran-6-one and 6H-benzo[b]naphtho[2, 3-d]pyran-6-one by two-dimensional nmr methods is described. The difference between the chemical shift values of H12 for these two compounds is attributed to different molecular geometries.

DOI： 10.1002/jhet.5570370446

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Biopharmaceutical Studies on Drug/Conjugated Metabolites Interactions: Application of Organic Sulfonic Compounds as Biodistribution Promoters

Yuhji Kurosaki, Yuhsuke Ohkawa, Kenji Sasaki, Taiji Nakayama

Pharmazie 2000年

Synthesis and chemiluminescence of 10-hydroxy- and 10- aminopyridazino[4,5-b]quinoline-1,4(2H, 3H)-diones

Yoshinori Tominaga, Noriko Yoshioka, Seigo Kataoka, Yasuhiro Shigemitsu, Takashi Hirota, Kenji Sasaki

Heterocycles 50 ( 1 ) 43 - 46 1999年1月

記述言語：英語出版者・発行元：Japan Institute of Heterocyclic Chemistry

Substituted anilines reacted with methyl 1-methyl-4-methylthio-2,5- dioxo-3-pyrroline-3-carboxylate (1) in refluxing methanol to give the corresponding methyl 1-methyl-2,5-dioxo-4-phenylamino-3-pyrroline-3- carboxylates (3a-e) which were converted in good yields to 2- methylpyrrolo[3,4-b]quinoline derivatives (4a-e) by heating in diphenyl ether. Reaction of 4a-e with hydrazine hydrate gave 10-hydroxypyridazino[4,5- b]quinoline-1,4(2H,3H)-diones (5a-e) in good yields. The desired 10- aminopyridazino[4,5-b]quinoline-1,4(2H, 3H)-diones (8a-e) were obtained by the chlorination of 4a-e with phosphorus oxychloride followed by ammonolysis with 28% ammonium hydroxide in good yields. Compounds (5) and (8) were found to be efficiently chemiluminescent in a similarly to luminol in the presence of H2O2 and horseradish peroxidase in a solution of a phosphate buffer pH 8.0.

DOI： 10.3987/COM-98-S(H)20

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A novel reaction of N-(5,6-dihydro[1]benzothiepino[5,4-d]pyrimidin-4-yl)amidine or its amide oxime derivatives with hydroxylamine(共著)

Journal of Heterocyclic Chemistry 36 ( 3 ) 787 - 791 1999年

Polycyclic N-heterocyclic compounds. 55 [1]. A novel reaction of N- (5,6-dihydro[1]benzothiepino[5,4-d]pyrimidin-4-yl)amidine or its amide oxime derivatives with hydroxylamine

Ying-Xue Zhang, Kenji Sasaki, Takashi Hirota

Journal of Heterocyclic Chemistry 36 ( 3 ) 787 - 791 1999年

記述言語：英語出版者・発行元：HeteroCorporation

The reactions of N-(5,6-dihydro[1]benzothiepino[5,4-d]pyrimidin-4- yl)amidines or its amide oxime derivatives with hydroxylamine hydrochloride under basic condition gave abnormal cyclization products via a ring cleavage of pyrimidine component accompanied with a ring closure of [1,2,4]oxadiazole.

DOI： 10.1002/jhet.5570360335

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Polycyclic N-Heterocyclic Compounds. 55. A novel reaction of N-(5,6-dihydro[1]benzothiepino[5,4-d]pyrimidin-4-yl)amidine or its amide oxime derivatives with hydroxylamine

Ying-Xue Zhang, Kenji Sasakii, Takashi Hirota

Journal of Heterocyclic Chemistry 1999年

Synthesis and pharmacological evaluation of 2,3,6,7-tetrahydrothieno[2,3-h]imidazo-[2,1-f][1,6]naphthyridines, 3,4,7,8-tetrahydro-2H-thieno[2,3-h]pyrimido[2,1-f][1,6]-naphthyridines and their precursor(共著)

Journal of Heterocyclic Chemistry 36 ( 2 ) 461 - 465 1999年

Polycyclic N-heterocyclic compounds. 50 [1]. Synthesis and pharmacological evaluation of 2,3,6,7-tetrahydrothieno[2,3-h]- imidazo[2,1 - f] [1,6] naphthyridines, 3,4,7,8-tetrahydro-2H-thieno[2,3-h]pyrimido[2,1- f][1,6]naphthyridines and their precursor

Kenji Sasaki, Abu Shara S. Rouf, Takashi Hirota, Naoki Nakaya

Journal of Heterocyclic Chemistry 36 ( 2 ) 461 - 465 1999年

記述言語：英語出版者・発行元：HeteroCorporation

Some novel 5-hydroxyalkylamino-1,2-dihydrothieno[2,3- h][1,6]naphthyridines were prepared by the reaction of 5-chloro-l,2- dihydrothieno[2,3-h][1,6]naphthyridine derivatives with some aminoalcohols in the presence of base. These derivatives were cyclized to the corresponding imidazo or pyrimido derivatives. The bronchodilatory activity of these compounds was evaluated on the basis of their relaxation activity to tracheal contraction induced by carbamylcholine chloride as a primary in vitro assays. Effect of some naphthyridines on carbamylcholine chloride-induced contractions of trachea in the presence or absence of milrinone or 4-(3- butoxy-4-methoxyphenyl)imidazolidin-2-one, which is inhibitor of phosphodiesterase III or IV, were also evaluated.

DOI： 10.1002/jhet.5570360221

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Synthesis and pharmacological evaluation of 2,3,6,7-tetrahydrothieno[2,3-h]imidazo[2,1- f][1,6]naphthyridines, 3,4,7,8-tetrahydro-2H-thieno[2,3-h]pyrimido[2,1- f][1,6]naphthyridines and their precursor

Kenji Sasaki, Abu Shara, Shamusur Rouf, Naoki Nakaya, Takashi Hirota

Journal of Heterocyclic Chemistry 1999年

Ring-cleavages and ring-closures of N-(benzo[h]quinazolin-4-yl)amidine and its amide oxime derivatives with hydroxylamine

Kenji Sasaki, Ying-Xue Zhang, Hiroshi Yamamoto, Setsuo Kashino, Takashi Hirota

Journal of Chemical Research (M) 1999年

Ring-cleavages and ring-closures of N-(benzo[h]quinazolin-4-yl)amidine and its amide oxime derivatives with hydroxylamine(共著)

Journal of Chemical Research(S) ( 2 ) 92 - 93 1999年

Polycyclic N-heterocyclic compounds. Part 54. Ring-cleavages and ring- closures of N-(benzo[h]quinazolin-4-yl)amidine and its amide oxime derivatives with hydroxylamine

Kenji Sasaki, Ying-Xue Zhang, Hiroshi Yamamoto, Setsuo Kashino, Takashi Hirota

Journal of Chemical Research - Part S ( 2 ) 92 - 93 1999年

記述言語：英語出版者・発行元：Royal Society of Chemistry

The synthesis of abnormal cyclization products, 2-(3-alkyl(or aryl)[1,2,4]oxadiazol-5-yl)-3,4-dihydro-1-naphthylaminoformaldehyde oximes and their homologues, by the reaction of N-(benzo[h]quinazolin-4-yl)amidine or its amide oxime derivatives with excess NH2OH·HCl are described.

DOI： 10.1039/a809077g

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