Faculty Profiles - FUJISAWA Masayoshi

MISC - FUJISAWA Masayoshi

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生検検体を用いた胆道癌におけるPD-L1発現の検討

松本和幸, 高木章乃夫, 大原利章, 藤澤真義, 高原政宏, 加藤博也, 吉田龍一, 楳田祐三, 八木孝仁, 松川昭博

日本消化器病学会雑誌 119 ( 臨増大会 ) A730 - A730 2022.10

松本和幸, 高木章乃夫, 大原利章, 藤澤真義, 高原政宏, 加藤博也, 吉田龍一, 楳田祐三, 八木孝仁, 松川昭博

日本消化器病学会雑誌 119 ( 臨増大会 ) A730 - A730 2022.10

Author Correction: Thioredoxin interacting protein protects mice from fasting induced liver steatosis by activating ER stress and its downstream signaling pathways. International journal

Hiroyuki Miyahara, Kosei Hasegawa, Masato Yashiro, Toshiaki Ohara, Masayoshi Fujisawa, Teizo Yoshimura, Akihiro Matsukawa, Hirokazu Tsukahara

Scientific reports 12 ( 1 ) 8026 - 8026 2022.5

Spred2は部分的にmiR-506-3p/KLF4/Stat3シグナルをターゲットしてHCCにおいて幹細胞性を制御する(Spred2 regulates stemness in HCC, partly targeting on miR-506-3p/KLF4/Stat3 signaling)

高桐, 藤澤真義, 大原利章, 吉村禎造, 松川昭博

日本病理学会会誌 111 ( 1 ) 228 - 228 2022.3

転移性トリプルネガティブ乳がんに対する鉄キレート剤の効果(Effects of Iron Chelators on Metastatic Triple-negative Breast Cancer)

王宇沢, 李春寧, 田ミャオ, 陳悦華, 吉村禎造, 藤澤真義, 大原利章, 松川昭博

日本病理学会会誌 111 ( 1 ) 284 - 284 2022.3

鉄キレート剤による偽低酸素は抗腫瘍効果とCD8+T細胞活性化を両立する(Pseudo-hypoxia by iron chelators consists anti-cancer effect and CD8+ T-cell activation)

陳悦華, 大原利章, 王宇沢, 濱田祐輔, 藤澤真義, 吉村禎造, 松川昭博

日本病理学会会誌 111 ( 1 ) 311 - 311 2022.3

鉄キレート剤は抗腫瘍効果の他に免疫活性効果を持っている(Iron chelator has anti-cancer effect and immune activation effect)

浜田祐輔, 大原利章, 王宇沢, 陳悦華, 吉村禎造, 藤澤真義, 松川昭博

日本病理学会会誌 111 ( 1 ) 324 - 324 2022.3

4T1細胞放出Wnt7aを含む小胞小体細胞亜群通信に関与し肺への細胞転移を促進(Interclonal Cooperation by Exosomal Wnt7a Promotes Lung Metastasis of the 4T1 Breast Cancer cells)

李春寧, 吉村禎造, 大原利章, 藤澤真義, 王宇沢, 松川昭博

日本病理学会会誌 111 ( 1 ) 253 - 253 2022.3

鉄キレート剤による偽低酸素は抗腫瘍効果とCD8+T細胞活性化を両立する(Pseudo-hypoxia by iron chelators consists anti-cancer effect and CD8+ T-cell activation)

陳悦華, 大原利章, 王宇沢, 濱田祐輔, 藤澤真義, 吉村禎造, 松川昭博

日本病理学会会誌 111 ( 1 ) 311 - 311 2022.3

肺腺癌におけるSpred2の発現と増殖・浸潤との関係(The role of Spred2 in lung adenocarcinoma)

太田陽子, ガオ・トン, 藤澤真義, 吉村禎造, 松川昭博

日本病理学会会誌 111 ( 1 ) 323 - 323 2022.3

鉄キレート剤は抗腫瘍効果の他に免疫活性効果を持っている(Iron chelator has anti-cancer effect and immune activation effect)

浜田祐輔, 大原利章, 王宇沢, 陳悦華, 吉村禎造, 藤澤真義, 松川昭博

日本病理学会会誌 111 ( 1 ) 324 - 324 2022.3

HCC細胞のオートファジーにおけるSpred2の機能及びm TOR活性化との関係(Role of Spred2 in autophagy in HCC cells and its relation to mTOR activation)

王天一, 高桐, 藤澤真義, 吉村禎造, 松川昭博

日本病理学会会誌 111 ( 1 ) 332 - 332 2022.3

李春寧, 吉村禎造, 大原利章, 藤澤真義, 王宇沢, 松川昭博

日本病理学会会誌 111 ( 1 ) 253 - 253 2022.3

腫瘍血管同定のための二重免疫染色と乳癌の予後判定への応用(Double immunostaining for tumor vessel identification and its application in breast cancer prognosis)

ニン・ウインウイン・・スウエ, 松川昭博, 藤澤真義

日本病理学会会誌 111 ( 1 ) 254 - 255 2022.3

転移性トリプルネガティブ乳がんに対する鉄キレート剤の効果(Effects of Iron Chelators on Metastatic Triple-negative Breast Cancer)

王宇沢, 李春寧, 田ミャオ, 陳悦華, 吉村禎造, 藤澤真義, 大原利章, 松川昭博

日本病理学会会誌 111 ( 1 ) 284 - 284 2022.3

高桐, 藤澤真義, 大原利章, 吉村禎造, 松川昭博

日本病理学会会誌 111 ( 1 ) 228 - 228 2022.3

Diagnostic Utility of the PD-L1 Immunostaining in Biopsy Specimens of Patients with Biliary Tract Neoplasms. International journal

Kazuyuki Matsumoto, Toshiaki Ohara, Masayoshi Fujisawa, Akinobu Takaki, Masahiro Takahara, Hironari Kato, Ryuichi Yoshida, Yuzo Umeda, Takahito Yagi, Akihiro Matsukawa, Hiroyuki Okada

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 26 ( 6 ) 1213 - 1223 2022.2

Language：English

BACKGROUND: Anti-programmed death 1/programmed death ligand 1 (PD1/PD-L1) antibodies have been successfully used as treatment agents for several solid tumors; however, it is difficult to predict their effectiveness. We evaluated whether biopsy specimens could predict the positive status of PD-L1 in surgically resected tissue. METHODS: Among 91 patients who underwent tissue sampling with endoscopic or liver biopsy before surgery for biliary tract neoplasms in an academic center, 45 (49%) patients were selected for retrospective analysis because the quality and quantity of their biopsy specimens were adequate for histologic evaluation. We performed immunohistochemical staining to investigate the PD-L1 expression in both resected and biopsy specimens. The percentage of the positively stained cells was calculated for subsequent use in the correlation investigation. RESULTS: The biopsy methods were endoscopic retrograde cholangiopancreatography (ERCP) in 28 cases, percutaneous liver biopsy in 10 cases, and endoscopic ultrasound fine-needle aspiration in 7 cases. Among the 45 patients, when patients with > 10% positive tumor cells in surgically resected tissues were regarded as truly positive PD-L1, the positive and negative concordance rates between surgically resected tissues and biopsy samples were 56% (5/9) and 100% (36/36), respectively. With regard to the use of preoperative biopsy as a diagnostic tool, all (5/5) PD-L1-positive patients had a positive resected specimen. The accuracy of each biopsy method was as follows: ERCP, 89% (25/28); fine-needle aspiration, 86% (6/7); and liver biopsy, 100% (10/10). CONCLUSIONS: Biopsy samples could be a surrogate material for the assessment of the PD-L1 expression with substantial positive and high negative concordance rates.

DOI： 10.1007/s11605-021-05197-6

PubMed

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生検検体を用いた胆道癌におけるPD-L1発現の検討

松本和幸, 高木章乃夫, 大原利章, 藤澤真義, 高原政宏, 加藤博也, 吉田龍一, 楳田祐三, 八木孝仁, 松川昭博

日本消化器病学会雑誌(Web) 119 2022

癌関連線維芽細胞に対する鉄キレート剤の効果(Effects of Iron Chelators on Cancer-associated Fibroblasts)

王宇沢, 大原利章, 李春寧, 田ミャオ, 小槙志保, 吉村禎造, 藤澤真義, 松川昭博

日本病理学会会誌 110 ( 1 ) 324 - 324 2021.3

HCC細胞のオートファジーにおけるSpred2の役割とERK活性化との関係(Role of Spred2 in autophagy in HCC cells and its relation to ERK activation)

王天一, 藤澤真義, 大原利章, 吉村禎造, 高桐, 松川昭博

日本病理学会会誌 110 ( 1 ) 314 - 314 2021.3

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MISC - FUJISAWA Masayoshi