研究者詳細 - 藤澤　真義

論文 - 藤澤　真義

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Papillary thyroid carcinoma arising from a median ectopic thyroid with no thyroglossal duct remnant

Tomoyasu Tachibana, Yorihisa Orita, Masayoshi Fujisawa, Yuya Ogawara

Acta Medica Okayama 67 ( 1 ) 61 - 64 2013年

Pathologic findings of autoimmune pancreatitis and IgG4-related disease

Kenji Notohara, Yoji Wani, Masayoshi Fujisawa

Current Immunology Reviews 7 ( 2 ) 212 - 220 2011年

Aberrant expression of an "intestinal marker" Cdx2 in pyloric gland adenoma of the gallbladder

Yoji Wani, Kenji Notohara, Masayoshi Fujisawa

Virchows Archiv 453 ( 5 ) 521 - 527 2008年11月

Solid pseudopapillary neoplasm: pathological diagnosis and distinction from other solid cellular tumours of the pancreas

Kenji Notohara, Yoji Wani, Masayoshi Fujisawa

Diagnostic Histopathology 14 ( 6 ) 266 - 274 2008年6月

Nonfunctioning endocrine pancreatic tumor examined with 18F-FDG PET/CT

Nobuyuki Toshikuni, Kyohei Kai, Masayoshi Fujisawa

Annals of Nuclear Medicine 22 ( 2 ) 133 - 137 2008年2月

CD56-positive cells with or without synaptophysin expression are recognized in the pancreatic duct epithelium: a study with adult and fetal tissues and specimens from chronic pancreatitis.

Fujisawa Masayoshi, Notohara Kenji, Tsukayama Choutatsu, Mizuno Ryuichirou, Okada Shigeru

Acta Medica Okayama 57 ( 6 ) 279 - 284 2003年12月

記述言語：英語出版者・発行元：Okayama University Medical School

<p>We observed the distribution of CD56+ epithelial cells in the pancreatic duct system using 25 fetal, one infantile, 3 normal adult, 4 diabetic, and 8 chronically inflamed pancreatic tissue samples. In the early stage of gestation (12 to 17 weeks), CD56+ cells were commonly seen in the immature tubular structures. They were often continuous to pancreatic islets, and their distribution was similar to that of synaptophysin (Syn)+ cells, suggesting that they are precursors of islet neogenesis. Their number decreased in proportion to gestational age. Instead, from 24 weeks of gestation, luminal cell clusters that were common in interlobular ducts revealed CD56+. These cell clusters were unrelated to islet neogenesis and Syn expression. Similar CD56+ luminal cell clusters were also observed in cases of chronic pancreatitis, whereas they were scarce in normal adult and diabetic tissues. CD56+ cells were also occasionally seen in intralobular ducts, intercalated ducts, and centroacinar cells in cases of chronic pancreatitis. We conclude that there are two types of CD56+ epithelial cells in the pancreatic duct system: CD56+ endocrine cells are numerous during the early stage of gestation, when islet neogenesis appears, while CD56+ luminal cells may represent developmental and regenerative changes of pancreatic ducts.</p>

DOI： 10.18926/AMO/32811

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Effects of phlebotomy on the growth of ferric nitrilotriacetate-induced renal cell carcinoma.

Mizote Akiko, Hida Akira I, Hosako Mutsumi, Fujisawa Masayoshi, Kamekawa Mika, Okada Shigeru

Acta Medica Okayama 56 ( 4 ) 199 - 204 2002年8月

記述言語：英語出版者・発行元：Okayama University Medical School

<p>The ferric nitrilotriacetate-induced carcinogenesis model is unique in that reactive oxygen species-free radicals are involved in the carcinogenic process. But the effects of iron-withdrawal in the progression of renal cell carcinoma are not well understood. We performed repeated phlebotomies on animals that had been administered ferric nitrilotriacetate in the initiation stage of renal cell carcinoma (phlebotomy group), and compared the development of renal tumors with those not receiving repeated phlebotomies (non-phlebotomy group). Ferric nitrilotriacetate-treated male Wistar rats were randomly divided into 2 groups: a phlebotomy group (21 rats) and a non-phlebotomy group (17 rats). Ten age-adjusted normal rats were also observed as a normal group. Hematocrit was maintained under 25% in the phlebotomy group. Hematocrit levels in the normal group and in the non-phlebotomy group were not significantly different. As a result, the incidence of renal cell carcinoma was not significantly different between phlebotomy and non-phlebotomy animals. However, the total weight of the renal cell carcinoma was significantly heavier in the animals from non-phlebotomy group than in those from the phlebotomy group (23.64 g +/- 18.54 vs. 54.40 g +/- 42.40, P < 0.05). The present study demonstrated that phlebotomy after the administration of ferric nitrilotriacetate did not reduce the incidence of renal cell carcinoma. In addition, we showed that iron withdrawal at the promotion stage of carcinogenesis will retard tumor growth.</p>

DOI： 10.18926/AMO/31687

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