Updated on 2022/07/02

写真a

 
FUJISAWA Masayoshi
 
Organization
Faculty of Medicine, Dentistry and Pharmaceutical Sciences Assistant Professor
Position
Assistant Professor
External link

Degree

  • 医学博士 ( 2003.9   岡山大学 )

Research Interests

  • blood vessel invasion

  • immunohistochemistry

  • breast cancer

  • cancer microenvironment

Research Areas

  • Life Science / Human pathology  / Diagnostic pathology

 

Papers

  • Expression of Spred2 in the urothelial tumorigenesis of the urinary bladder Reviewed

    Shinsuke Oda, Masayoshi Fujisawa, Li Chunning, Toshihiro Ito, Takahiro Yamaguchi, Teizo Yoshimura, Akihiro Matsukawa

    PLos ONE   16 ( 11 )   ee0254289   2021.11

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  • Thioredoxin interacting protein protects mice from fasting induced liver steatosis by activating ER stress and its downstream signaling pathways. International journal

    Hiroyuki Miyahara, Kosei Hasegawa, Masato Yashiro, Toshiaki Ohara, Masayoshi Fujisawa, Teizo Yoshimura, Akihiro Matsukawa, Hirokazu Tsukahara

    Scientific reports   12 ( 1 )   4819 - 4819   2022.3

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    Under normal conditions, fasting results in decreased protein disulfide isomerase (PDI) activity and accumulation of unfolded proteins, leading to the subsequent activation of the unfolded protein response (UPR)/autophagy signaling pathway to eliminate damaged mitochondria. Fasting also induces upregulation of thioredoxin-interacting protein (TXNIP) expression and mice deficient of this protein (TXNIP-KO mice) was shown to develop severe hypoglycemia, hyperlipidemia and liver steatosis (LS). In the present study, we aimed to determine the role of TXNIP in fasting-induced LS by using male TXNIP-KO mice that developed LS without severe hypoglycemia. In TXNIP-KO mice, fasting induced severe microvesicular LS. Examinations by transmission electron microscopy revealed mitochondria with smaller size and deformities and the presence of few autophagosomes. The expression of β-oxidation-associated genes remained at the same level and the level of LC3-II was low. PDI activity level stayed at the original level and the levels of p-IRE1 and X-box binding protein 1 spliced form (sXBP1) were lower. Interestingly, treatment of TXNIP-KO mice with bacitracin, a PDI inhibitor, restored the level of LC3-II after fasting. These results suggest that TXNIP regulates PDI activity and subsequent activation of the UPR/autophagy pathway and plays a protective role in fasting-induced LS.

    DOI: 10.1038/s41598-022-08791-z

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  • Diagnostic Utility of the PD-L1 Immunostaining in Biopsy Specimens of Patients with Biliary Tract Neoplasms. International journal

    Kazuyuki Matsumoto, Toshiaki Ohara, Masayoshi Fujisawa, Akinobu Takaki, Masahiro Takahara, Hironari Kato, Ryuichi Yoshida, Yuzo Umeda, Takahito Yagi, Akihiro Matsukawa, Hiroyuki Okada

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract   2022.2

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    BACKGROUND: Anti-programmed death 1/programmed death ligand 1 (PD1/PD-L1) antibodies have been successfully used as treatment agents for several solid tumors; however, it is difficult to predict their effectiveness. We evaluated whether biopsy specimens could predict the positive status of PD-L1 in surgically resected tissue. METHODS: Among 91 patients who underwent tissue sampling with endoscopic or liver biopsy before surgery for biliary tract neoplasms in an academic center, 45 (49%) patients were selected for retrospective analysis because the quality and quantity of their biopsy specimens were adequate for histologic evaluation. We performed immunohistochemical staining to investigate the PD-L1 expression in both resected and biopsy specimens. The percentage of the positively stained cells was calculated for subsequent use in the correlation investigation. RESULTS: The biopsy methods were endoscopic retrograde cholangiopancreatography (ERCP) in 28 cases, percutaneous liver biopsy in 10 cases, and endoscopic ultrasound fine-needle aspiration in 7 cases. Among the 45 patients, when patients with > 10% positive tumor cells in surgically resected tissues were regarded as truly positive PD-L1, the positive and negative concordance rates between surgically resected tissues and biopsy samples were 56% (5/9) and 100% (36/36), respectively. With regard to the use of preoperative biopsy as a diagnostic tool, all (5/5) PD-L1-positive patients had a positive resected specimen. The accuracy of each biopsy method was as follows: ERCP, 89% (25/28); fine-needle aspiration, 86% (6/7); and liver biopsy, 100% (10/10). CONCLUSIONS: Biopsy samples could be a surrogate material for the assessment of the PD-L1 expression with substantial positive and high negative concordance rates.

    DOI: 10.1007/s11605-021-05197-6

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  • Spred2 controls the severity of Concanavalin A-induced liver damage by limiting interferon-gamma production by CD4+ and CD8+ T cells. International journal

    Cuiming Sun, Masayoshi Fujisawa, Toshiaki Ohara, Qiuying Liu, Chen Cao, Xu Yang, Teizo Yoshimura, Steven L Kunkel, Akihiro Matsukawa

    Journal of advanced research   35   71 - 86   2022.1

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    Introduction: Mitogen-activated protein kinases (MAPKs) are involved in T cell-mediated liver damage. However, the inhibitory mechanism(s) that controls T cell-mediated liver damage remains unknown. Objectives: We investigated whether Spred2 (Sprouty-related, EVH1 domain-containing protein 2) that negatively regulates ERK-MAPK pathway has a biological impact on T cell-mediated liver damage by using a murine model. Methods: We induced hepatotoxicity in genetically engineered mice by intravenously injecting Concanavalin A (Con A) and analyzed the mechanisms using serum chemistry, histology, ELISA, qRT-PCR, Western blotting and flow cytometry. Results: Spred2-deficient mice (Spred2-/-) developed more sever liver damage than wild-type (WT) mice with increased interferon-γ (IFNγ) production. Hepatic ERK phosphorylation was enhanced in Spred2-/- mice, and pretreatment of Spred2-/- mice with the MAPK/ERK inhibitor U0126 markedly inhibited the liver damage and reduced IFNγ production. Neutralization of IFNγ abolished the damage with decreased hepatic Stat1 activation in Spred2-/- mice. IFNγ was mainly produced from CD4+ and CD8+ T cells, and their depletion decreased liver damage and IFNγ production. Transplantation of CD4+ and/or CD8+ T cells from Spred2-/- mice into RAG1-/- mice deficient in both T and B cells caused more severe liver damage than those from WT mice. Hepatic expression of T cell attractants, CXCL9 and CXCL10, was augmented in Spred2-/- mice as compared to WT mice. Conversely, liver damage, IFNγ production and the recruitment of CD4+ and CD8+ T cells in livers after Con A challenge were lower in Spred2 transgenic mice, and Spred2-overexpressing CD4+ and CD8+ T cells produced lower levels of IFNγ than WT cells upon stimulation with Con A in vitro. Conclusion: We demonstrated, for the first time, that Spred2 functions as an endogenous regulator of T cell IFNγ production and Spred2-mediated inhibition of ERK-MAPK pathway may be an effective remedy for T cell-dependent liver damage.

    DOI: 10.1016/j.jare.2021.03.014

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  • Crosstalk between Cancer Cells and Fibroblasts for the Production of Monocyte Chemoattractant Protein-1 in the Murine 4T1 Breast Cancer. International journal

    Mayu Imamura, Tiantian Li, Chunning Li, Masayoshi Fujisawa, Naofumi Mukaida, Akihiro Matsukawa, Teizo Yoshimura

    Current issues in molecular biology   43 ( 3 )   1726 - 1740   2021.10

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    The chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2) is shown to promote the progression of breast cancer. We previously identified cancer cell-derived granulocyte-macrophage colony-stimulating factor (GM-CSF) as a potential regulator of MCP-1 production in the murine 4T1 breast cancer, but it played a minimum role in overall MCP-1 production. Here, we evaluated the crosstalk between 4T1 cells and fibroblasts. When fibroblasts were co-cultured with 4T1 cells or stimulated with the culture supernatants of 4T1 cells (4T1-sup), MCP-1 production by fibroblasts markedly increased. 4T1 cells expressed mRNA for platelet-derived growth factor (PDGF)-a, b and c, and the PDGF receptor inhibitor crenolanib almost completely inhibited 4T1-sup-induced MCP-1 production by fibroblasts. However, PDGF receptor antagonists failed to reduce MCP-1 production in tumor-bearing mice. Histologically, 4T1 tumors contained a small number of αSMA-positive fibroblasts, and Mcp-1 mRNA was mainly associated with macrophages, especially those surrounding necrotic lesions on day 14, by in situ hybridization. Thus, although cancer cells have the capacity to crosstalk with fibroblasts via PDGFs, this crosstalk does not play a major role in MCP-1 production or cancer progression in this model. Unraveling complex crosstalk between cancer cells and stromal cells will help us identify new targets to help treat breast cancer patients.

    DOI: 10.3390/cimb43030122

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  • PolyI:C suppresses TGF-β1-induced Akt phosphorylation and reduces the motility of A549 lung carcinoma cells. International journal

    Takahiro Yamaguchi, Teizo Yoshimura, Toshiaki Ohara, Masayoshi Fujisawa, Gao Tong, Akihiro Matsukawa

    Molecular biology reports   2021.8

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    BACKGROUNDS: Epithelial mesenchymal transition (EMT) is a critical process involved in the invasion and metastasis of cancer, including lung cancer (LC). Transforming growth factor (TGF)-β is one of factors capable of inducing EMT. Polyinosinic-polycytidylic acid (polyI:C), a synthetic agonist for toll-like receptor (TLR) 3, can enhance immune responses and has been used as an adjuvant for cancer vaccines; however, it remains unclear whether it influences other process, such as EMT. In the present study, we examined the effects of polyI:C on TGF-β-treated A549 human LC cells. METHODS AND RESULTS: By in vitro cell proliferation assay, polyI:C showed no effect on the growth of A549 cells treated with TGF-β1 at the concentration range up to 10 μg/ml; however, it markedly suppressed the motility in a cell scratch and a cell invasion assay. By Western blotting, polyI:C dramatically decreased TGF-β1-induced Ak strain transforming (Akt) phosphorylation and increased phosphatase and tensin homologue (PTEN) expression without affecting the Son of mothers against decapentaplegic (Smad) 3 phosphorylation or the expression level of E-cadherin, N-cadherin or Snail, indicating that polyI:C suppressed cell motility independently of the 'cadherin switching'. The Akt inhibitor perifosine inhibited TGF-β1-induced cell invasion, and the PTEN-specific inhibitor VO-OHpic appeared to reverse the inhibitory effect of polyI:C. CONCLUSION: PolyI:C has a novel function to suppress the motility of LC cells undergoing EMT by targeting the phosphatidylinositol 3-kinase/Akt pathway partly via PTEN and may prevent or reduce the metastasis of LC cells.

    DOI: 10.1007/s11033-021-06625-1

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  • 癌関連線維芽細胞に対する鉄キレート剤の効果(Effects of Iron Chelators on Cancer-associated Fibroblasts)

    王 宇沢, 大原 利章, 李 春寧, 田 ミャオ, 小槙 志保, 吉村 禎造, 藤澤 真義, 松川 昭博

    日本病理学会会誌   110 ( 1 )   324 - 324   2021.3

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  • 腫瘍環境のSpred2欠損は4T1乳がん細胞の増殖と転移を抑制する(Spred2 deficiency in cancer microenvironment inhibits progression of 4T1 breast cancer cells in mice)

    Tian Miao, 吉村 禎造, 李 春寧, 大原 利章, 藤澤 真義, 松川 昭博

    日本病理学会会誌   110 ( 1 )   324 - 324   2021.3

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  • Spred2はHCCで幹細胞性をmiR-506-3pによって一部負に抑制する(Spred2 down-regulates stemness in HCC partly through targeting miR-506-3p)

    高 桐, 藤澤 真義, Aye Moh Moh Aung, 大原 利章, 吉村 禎造, 王 天一, 伊藤 佐智夫, 松川 昭博

    日本病理学会会誌   110 ( 1 )   225 - 225   2021.3

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  • HCC細胞のオートファジーにおけるSpred2の役割とERK活性化との関係(Role of Spred2 in autophagy in HCC cells and its relation to ERK activation)

    王 天一, 藤澤 真義, 大原 利章, 吉村 禎造, 高 桐, 松川 昭博

    日本病理学会会誌   110 ( 1 )   314 - 314   2021.3

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  • 異なる亜集団の腫瘍細胞から放出されたエクソソームWnt7aによリ4T1細胞の転移は促進される(4T1 cells promote tumor metastasis by exosomal Wnt7a released from distinct subpopulations)

    李 春寧, 大原 利章, 藤澤 真義, 阪口 政清, 山本 健一, 田 ミャオ, 王 宇沢, 吉村 禎造, 松川 昭博

    日本病理学会会誌   110 ( 1 )   231 - 231   2021.3

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  • 乳癌における傍導管浸潤(periductal invasion)の臨床病理学的意義

    藤澤 真義, 大森 昌子, 松川 昭博

    日本病理学会会誌   110 ( 1 )   322 - 322   2021.3

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  • 4T1乳癌モデルにおいてMCP-1産生を促す癌細胞・線維芽細胞間のクロストーク(Crosstalk between cancer cells and fibroblasts for MCP: production of MCP-1 in 4T1 breast cancer)

    吉村 禎造, 今村 真悠, り・てぃあんてぃあん, てぃあん・みあお, 李 春寧, 藤澤 真義, 松川 昭博

    日本病理学会会誌   110 ( 1 )   231 - 231   2021.3

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  • 肺腺癌におけるSpred2の発現と増殖、浸潤との関連の検討

    太田 陽子, 藤澤 真義, 吉村 禎造, スマルディカ・イワヤン, 枝園 和彦, 阪口 政清, 豊岡 伸一, 松川 昭博

    日本病理学会会誌   110 ( 1 )   291 - 291   2021.3

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  • Detection of cutaneous prion protein deposits could help diagnose GPI-anchorless prion disease with neuropathy. Reviewed International journal

    Hiroyuki Honda, Kosuke Matsuzono, Kota Satoh, Masayoshi Fujisawa, Satoshi O Suzuki, Chiaki Furuyama, Tetsuyuki Kitamoto, Shigeru Fujimoto, Koji Abe, Toru Iwaki

    European journal of neurology   28 ( 6 )   2133 - 2137   2021.1

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    BACKGROUND AND PURPOSE: To investigate prion protein (PrP) deposits in cutaneous tissues of patients of glycosylphosphatidylinositol (GPI)-anchorless prion diseases with neuropathy. METHODS: Cutaneous tissue samples from three patients with GPI-anchorless prion diseases were obtained, two cutaneous biopsy samples from the lower leg of Case 1 (Y162X) and Case 3 (D178fs25), and a cutaneous sample taken from the abdomen during an autopsy of Case 2 (D178fs25). We performed immunohistochemistry for PrP to look for abnormal PrP deposits. RESULTS: PrP deposits were observed in the dermal papilla, the sweat glands, the hair follicles, the arrector pili muscles, and peripheral nerves of all examined cases of GPI-anchorless prion disease with neuropathy. The abnormal PrP accumulation was frequently localized at the basement membrane, and colocalized with laminin. CONCLUSION: Immunohistochemical detection of PrP in cutaneous samples could be used to definitively diagnose GPI-anchorless PrP disease with neuropathy.

    DOI: 10.1111/ene.14720

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  • Expression of Spred2 in the urothelial tumorigenesis of the urinary bladder. International journal

    Shinsuke Oda, Masayoshi Fujisawa, Li Chunning, Toshihiro Ito, Takahiro Yamaguchi, Teizo Yoshimura, Akihiro Matsukawa

    PloS one   16 ( 11 )   e0254289   2021

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    Aberrant activation of the Ras/Raf/ERK (extracellular-signal-regulated kinase)-MAPK (mitogen-activated protein kinase) pathway is involved in the progression of cancer, including urothelial carcinoma; but the negative regulation remains unclear. In the present study, we investigated pathological expression of Spred2 (Sprouty-related EVH1 domain-containing protein 2), a negative regulator of the Ras/Raf/ERK-MAPK pathway, and the relation to ERK activation and Ki67 index in various categories of 275 urothelial tumors obtained from clinical patients. In situ hybridization demonstrated that Spred2 mRNA was highly expressed in high-grade non-invasive papillary urothelial carcinoma (HGPUC), and the expression was decreased in carcinoma in situ (CIS) and infiltrating urothelial carcinoma (IUC). Immunohistochemically, membranous Spred2 expression, important to interact with Ras/Raf, was preferentially found in HGPUC. Interestingly, membranous Spred2 expression was decreased in CIS and IUC relative to HGPUC, while ERK activation and the expression of the cell proliferation marker Ki67 index were increased. HGPUC with membranous Spred2 expression correlated significantly with lower levels of ERK activation and Ki67 index as compared to those with negative Spred2 expression. Thus, our pathological findings suggest that Spred2 counters cancer progression in non-invasive papillary carcinoma possibly through inhibiting the Ras/Raf/ERK-MAPK pathway, but this regulatory mechanism is lost in cancers with high malignancy. Spred2 appears to be a key regulator in the progression of non-invasive bladder carcinoma.

    DOI: 10.1371/journal.pone.0254289

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  • Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin. International journal

    Akina Kawara, Ryo Mizuta, Masayoshi Fujisawa, Toshihiro Ito, Chunning Li, Kaoru Nakamura, Cuiming Sun, Masaki Kuwabara, Masahiro Kitabatake, Teizo Yoshimura, Akihiro Matsukawa

    Scientific reports   10 ( 1 )   16490 - 16490   2020.10

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    The mitogen-activated protein kinase (MAPK) pathways are involved in many cellular processes, including the development of fibrosis. Here, we examined the role of Sprouty-related EVH-1-domain-containing protein (Spred) 2, a negative regulator of the MAPK-ERK pathway, in the development of bleomycin (BLM)-induced pulmonary fibrosis (PF). Compared to WT mice, Spred2-/- mice developed milder PF with increased proliferation of bronchial epithelial cells. Spred2-/- lung epithelial cells or MLE-12 cells treated with spred2 siRNA proliferated faster than control cells in vitro. Spred2-/- and WT macrophages produced similar levels of TNFα and MCP-1 in response to BLM or lipopolysaccharide and myeloid cell-specific deletion of Spred2 in mice had no effect. Spred2-/- fibroblasts proliferated faster and produced similar levels of MCP-1 compared to WT fibroblasts. Spred2 mRNA was almost exclusively detected in bronchial epithelial cells of naïve WT mice and it accumulated in approximately 50% of cells with a characteristic of Clara cells, 14 days after BLM treatment. These results suggest that Spred2 is involved in the regulation of tissue repair after BLM-induced lung injury and increased proliferation of lung bronchial cells in Spred2-/- mice may contribute to faster tissue repair. Thus, Spred2 may present a new therapeutic target for the treatment of PF.

    DOI: 10.1038/s41598-020-73752-3

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  • Decreased miR-200b-3p in cancer cells leads to angiogenesis in HCC by enhancing endothelial ERG expression Reviewed

    Aye Moh-Moh-Aung, Masayoshi Fujisawa, Sachio Ito, Hiroshi Katayama, Toshiaki Ohara, Yoko Ota, Teizo Yoshimura, Akihiro Matsukawa 3

    Scientific Reports   26 ( 10 )   10418   2020.10

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  • A case of Down syndrome with prenatal onset of transient abnormal myelopoiesis and fetal vascular malperfusion of the placenta Reviewed

    Japanese Journal of Diagnostic Pathology   34 ( 4 )   428 - 434   2020.10

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  • Elastin and collagen IV double staining: A refined method to detect blood vessel invasion in breast cancer Reviewed

    Masayoshi Fujisawa, Masako Omori, Hiroyoshi Doihara, Ye‐Min Than, Hnin Wint Wint Swe, Teizo Yoshimura, Akihiro Matsukawa

    Pathology International   70 ( 9 )   612 - 623   2020.9

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  • Spred2欠損はコンカナバリンA誘発性肝傷害をCXCL9/10を介したT細胞の誘引により悪化させる(Spred2 deficiency exacerbated Concanavalin A-induced liver injury by attracting T cells via CXCL9/10)

    孫 翠明, 吉村 禎造, 藤澤 真義, 大原 利章, 松川 昭博

    日本病理学会会誌   109 ( 1 )   346 - 347   2020.3

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  • Spred2は腫瘍幹細胞性の維持に関与しHepG2 HCCの悪性度を低下させる(Spred2 involved in tumor stemness maintenance down-regulates malignant potential of HepG2 HCC)

    高 桐, 吉村 禎造, 大原 利章, 藤澤 真義, 松川 昭博

    日本病理学会会誌   109 ( 1 )   348 - 348   2020.3

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  • 乳癌における血管浸潤の検索法 新規法(Elastin and collagen 4 double staining)と従来法との比較検討

    藤澤 真義, 大森 昌子, 松川 昭博

    日本病理学会会誌   109 ( 1 )   311 - 311   2020.3

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  • 癌転移は,エキソソームの異なる細胞亜群からの放出によって調節される(Cancer metastasis is regulated via exosomes released from distinct cell subpopulation)

    李 春寧, 吉村 禎造, 田 ミョウ, 大原 利章, 藤澤 真義, 松川 昭博

    日本病理学会会誌   109 ( 1 )   358 - 358   2020.3

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  • 急激な経過をたどりdiffuse alveolar hemorrhageにて死亡したSLEの一例

    河原 明奈, 藤澤 真義, 松川 昭博

    日本病理学会会誌   109 ( 1 )   484 - 484   2020.3

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  • 膵癌におけるFNA検体と切除検体とのPD-L1発現の検討

    松本 和幸, 高木 章乃夫, 大原 利章, 藤澤 真義, 高原 政宏, 加藤 博也, 吉田 龍一, 楳田 祐三, 八木 孝仁, 松川 昭博, 岡田 裕之

    日本消化器病学会雑誌   116 ( 臨増大会 )   A826 - A826   2019.11

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  • HepG2細胞におけるSpred2遺伝子の不活化はERK経路を活性化して細胞増殖、移動および浸潤を促進する(Spred2 deletion accelerates growth, migration and invasion in HepG2 cells by activating ERK pathway)

    高 桐, 楊 旭, 藤澤 真義, 大原 利章, 吉村 禎造, 松川 昭博

    日本病理学会会誌   108 ( 1 )   382 - 382   2019.4

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  • Spred2はINF gamma生産を調節することによりマウスのConA誘発肝障害を予防する(Spred2 protects mice from ConA-induced liver injury by regulating IFN gamma production)

    孫 翠明, 藤澤 真義, 大原 利章, 吉村 禎造, 松川 昭博

    日本病理学会会誌   108 ( 1 )   382 - 382   2019.4

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  • 高齢発症で再発を繰り返し、致死的な経過をたどった若年性顆粒膜細胞腫の一例(Juvenile granulosa cell tumor with unusual clinical course: a late-onset and late recurrent case)

    太田 陽子, タテ・サン, 伏見 聡一郎, 藤澤 真義, 柳井 広之, 戸田 博子, 大森 昌子, 國友 忠義, 松川 昭博

    日本病理学会会誌   108 ( 1 )   408 - 408   2019.4

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  • マウス4T1乳癌モデルにおける新たなMCP-1産生機序の同定 腫瘍細胞・線維芽細胞間のクロストーク

    今村 真悠, 藤澤 真義, Li Tiantian, 河原 明奈, 松川 昭博, 吉村 禎造

    日本病理学会会誌   108 ( 1 )   461 - 461   2019.4

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  • 癌細胞が産生するGM-CSFは、癌の進展・転移に関わるか? マウス4T1乳癌モデルでの検討

    中村 薫, Li Chunning, Li Tiantian, 藤澤 真義, 松川 昭博, 向田 直史, 吉村 禎造

    日本病理学会会誌   108 ( 1 )   464 - 464   2019.4

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  • 乳癌における静脈浸潤の新規検索法

    藤澤 真義, モウモウアウン・エイ, 柳井 広之, 大森 昌子, 松川 昭博

    日本病理学会会誌   108 ( 1 )   289 - 289   2019.4

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  • miR-200b-3p発現低下は転写因子ERGを標的として肝細胞癌の血管新生に関与する(Downregulated miR-200b-3p plays a role in angiogenesis of hepatocellular carcinoma by targeting ERG)

    エイ・モウモウ・アウン, 藤澤 真義, 吉村 禎造, 松川 昭博

    日本病理学会会誌   108 ( 1 )   329 - 329   2019.4

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  • 肺線維芽細胞の増殖におけるSpred2の役割

    河原 明奈, 水田 亮, 藤澤 真義, 吉村 禎造, 松川 昭博

    日本病理学会会誌   108 ( 1 )   353 - 353   2019.4

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  • 異なる細胞亜集団に由来するエキソソームによって癌の進行が制御される可能性(Cancer progression can be regulated by exosomes from distinct cell subpopulation)

    李 春寧, 田 ミョウ, 大原 利章, 藤澤 真義, 吉村 禎造, 松川 昭博

    日本病理学会会誌   108 ( 1 )   394 - 394   2019.4

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  • Ovarian stromal cells as a source of cancer-associated fibroblasts in human epithelial ovarian cancer: A histopathological study. Reviewed

    Fujisawa M, Aye Moh-Moh-Aung, Zeng Z, Wani Y, Matsukawa A.

    PLoS One   13 ( 10 )   e0205494   2018.10

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  • spred-2は肝傷害を保護する(Spred-2 protects mice from ConA-induced liver injury)

    孫 翠明, 吉村 禎造, 藤澤 真義, 大原 利章, 楊 旭

    日本病理学会会誌   107 ( 1 )   368 - 368   2018.4

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  • Spred2欠損は内臓脂肪織炎、インスリン抵抗性を増悪させる

    大倉 隆宏, 丸谷 梨栄, 吉村 禎造, 藤澤 真義, 大原 利章, 松川 昭博

    日本病理学会会誌   107 ( 1 )   347 - 347   2018.4

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  • 4T1マウス乳癌の進展におけるがん細胞由来GM-CSFの果たす役割(The role of tumor cell-derived GM-CSF in the progression of 4T1 murine breast cancer)

    吉村 禎造, 中村 薫, 佐藤 美和, 李 春寧, 藤澤 真義, 向田 直史, 松川 昭博

    日本病理学会会誌   107 ( 1 )   341 - 341   2018.4

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  • microRNA 200b-3pはERGを標的とすることで肝細胞癌の血管新生に関与している可能性がある(MicroRNA 200b-3p May Play a Role in Angiogenesis of Hepatocellular Carcinoma by Targeting ERG)

    エイ・モゥモゥ・アウン, 藤澤 真義, 吉村 禎造, 松川 昭博

    日本病理学会会誌   107 ( 1 )   369 - 369   2018.4

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  • 肺腺がんにおけるSpred2の役割の解明

    太田 陽子, 藤澤 真義, 吉村 禎造, スマルディカ・イワヤン, 枝園 和彦, 阪口 政清, 豊岡 伸一, 松川 昭博

    日本病理学会会誌   107 ( 1 )   414 - 414   2018.4

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  • 胎児期に一過性骨髄異常増殖症を発症し胎盤にfetal thrombotic vasculopathyを伴ったダウン症の1例

    濱崎 友洋, 藤澤 真義, 伏見 聡一郎, 堀田 真智子, 苗村 智, 和仁 洋治, 吉村 禎造, 松川 昭博

    日本病理学会会誌   107 ( 1 )   530 - 530   2018.4

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  • ヒト卵巣癌における線維芽細胞の由来

    藤澤 真義, 柳井 広之, 和仁 洋治, 伏見 聡一郎, 松川 昭博

    日本病理学会会誌   107 ( 1 )   389 - 389   2018.4

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  • ブレオマイシン肺線維症モデルにおけるSpred-2の役割

    河原 明奈, 水田 亮, 藤澤 真義, 吉村 禎造, 松川 昭博

    日本病理学会会誌   107 ( 1 )   413 - 413   2018.4

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  • Biphenotypic sinonasal sarcomaの1例

    林 詠子, 祇園 由佳, 藤澤 真義, 能島 舞, 田中 顕之, 田中 健大, 柳井 広之, 吉野 正

    診断病理   34 ( 4 )   293 - 298   2017.10

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    患者は50代女性。半年前から徐々に増悪する右鼻閉を訴えていた。画像検査にて頭蓋底に浸潤する右鼻腔・右篩骨洞腫瘤を指摘され、摘出術が施行された。組織学的に上皮下に紡錐形核を有する均一な細胞が束状に増殖しており、staghorn patternを示す血管がみられた。細胞異型や核分裂像に乏しく、壊死はみられなかった。免疫組織化学的に紡錐形細胞はS100蛋白(+)、α-smooth muscle actin(+)、Ki-67陽性率は1%以下であった。電子顕微鏡にて細胞質内にfocal dense plaqueを、RT-PCRにてPAX3-FOXO1融合遺伝子産物が認められた。以上より近年sinonasal tractに発生する新しい腫瘍の一つとして提唱された、biphenotypic sinonasal sarcomaと診断した。(著者抄録)

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  • Sarcomatoid changeがみられたclear cell RCC with unusual papillary configurationの一例

    河原 明奈, 藤澤 真義, 黒田 直人, 松川 昭博

    日本病理学会会誌   106 ( 2 )   93 - 93   2017.9

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  • Molecular subtypes of breast cancers from Myanmar women: a study of 91 cases at two pathology centers.Asian Pacific Journal of Cancer Prevention Reviewed

    San TH, Fujisawa M, Fushimi S, Soe L, Min NW, Yoshimura T, Ohara T, Yee MM, Oda S, Matsukawa A

    Asian Pac J Cancer Prev.   18 ( 6 )   1617 - 1621   2017.6

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  • Molecular subtypes of breast cancers from Myanmar women Reviewed

    Thar Htet San,Masayoshi Fujisawa*,Soichiro Fushimi,Lamin Soe,Ngu Wah Min,Teizo Yoshimura*,Toshiaki Ohara*,Myint Myint Yee,Shinsuke Oda,Akihiro Matsukawa*

    Asian Pacific Journal of Cancer Prevention, Asian Pacific journal of cancer prevention : APJCP   18 ( 6 )   1617 - 1621   2017.6

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    DOI: 10.22034/APJCP.2017.18.6.1617

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  • Low prevalence of human mammary tumor virus (HMTV) in breast cancer patients from Myanmar Reviewed

    San TH, Fujisawa M, Fushimi S, Yoshimura T, Ohara T, Soe L, Min NW, Kyaw O, Yang X,?Matsukawa A

    Infect Agent Cancer   12 ( 20 )   2017.4

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    DOI: 10.1186/s13027-017-0130-0

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  • Low prevalence of human mammary tumor virus (HMTV) in breast cancer patients from Myanmar Reviewed

    Thar Htet San,Masayoshi Fujisawa*,Soichiro Fushimi,Teizo Yoshimura*,Toshiaki Ohara*,Lamin Soe,Ngu Wah Min,Ohnmar Kyaw,Xu Yang,Akihiro Matsukawa*

    Infectious Agents and Cancer   12 ( 1 )   60 - 66   2017.4

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    DOI: 10.1186/s13027-017-0130-0

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  • Spred-2欠損はGalN/LPS誘導性の急性肝障害を悪化させる(Spred-2 deficiency exacerbated GalN/LPS induced acute liver injury)

    楊 旭, 吉村 禎造, 藤澤 真義, 大原 利章, 佐藤 美和, 美野 愛, 松川 昭博

    日本病理学会会誌   106 ( 1 )   446 - 446   2017.3

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  • polyI:CによるAktリン酸化抑制を介した腫瘍細胞の転移抑制機構(Poly I:C suppress migration of carcinoma cells by inhibiting Akt phosphorylation)

    山口 隆廣, 吉村 禎造, 大原 利章, 藤澤 真義, 松川 昭博

    日本病理学会会誌   106 ( 1 )   282 - 282   2017.3

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  • ヒト卵巣癌における線維芽細胞の由来

    藤澤 真義, 柳井 広之, 和仁 洋治, 松川 昭博

    日本病理学会会誌   106 ( 1 )   318 - 318   2017.3

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  • 間質性肺炎モデルにおけるSpred-2の役割

    河原 明奈, 藤澤 真義, 吉村 禎造, 松川 昭博

    日本病理学会会誌   106 ( 1 )   330 - 330   2017.3

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  • 前頭葉に発生し,てんかん原性を示した髄膜腫合併髄膜血管腫症の1例 Reviewed

    河原明奈、伏見聡一郎、板倉淳哉、藤澤真義、小林勝弘、林裕美子、伊達勲、上利崇、柳井広之、松川昭博

    診断病理   34 ( 1 )   46 - 50   2017.1

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  • A Novel Role of Spred2 in the Colonic Epithelial Cell Homeostasis and Inflammation.(共著Scientific reports) Reviewed

    Scientific reports   21 ( 6 )   37531   2016.11

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    DOI: 10.1038/srep37531

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  • Alveolar soft part sarcoma in the thigh: a case report. Reviewed

    Japanese Journal of Diagnostic Pathology   33 ( 2 )   158 - 162   2016.4

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  • ミャンマーの乳がんの組織学的側面(Histologic Profile of Breast Cancer in Myanmar)

    サン・タ・テ, 藤澤 真義, 伏見 聡一郎, イー・ミント・ミント, Yang Xu, Aye Moh Moh Aung, 渡邉 治之, 荒嶋 康晴, 大原 利章, 松川 昭博

    日本病理学会会誌   105 ( 1 )   566 - 566   2016.4

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  • Spred-2欠損はGalN/LPS誘導性の急性腎障害を悪化させる(Spred-2 deficiency exacerbates D-Galactosamine/lipopolysaccharide -induced acute liver injury)

    楊 旭, 吉村 禎造, 藤澤 真義, 大原 利章, 山口 隆廣, サン・タ・テ, 小田 晋輔, 佐藤 美和, 美野 愛, 松川 昭博

    日本病理学会会誌   105 ( 1 )   449 - 450   2016.4

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  • てんかんの原因となった、髄膜腫を併存した髄膜血管腫症の1例

    河原 明奈, 伏見 聡一郎, 板倉 淳哉, 小田 晋輔, 太田 陽子, 堀田 真智子, 藤澤 真義, 柳井 広之, 松川 昭博

    日本病理学会会誌   105 ( 1 )   562 - 562   2016.4

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  • Spred-2欠損によるシスプラチン腎障害増悪における好中球の関与

    藤井 裕生, 何 佳利, 吉村 禎造, 藤澤 真義, 佐藤 美和, 楊 旭, 松川 昭博

    日本病理学会会誌   105 ( 1 )   592 - 592   2016.4

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  • 多房性嚢胞性変化を呈したsex cord tumor with annular tubules(SCTAT)の一例

    太田 陽子, 伏見 聡一郎, 堀田 真智子, 河田 卓也, サン・タ・テ, 内野 かおり, 藤澤 真義, 和仁 洋治, 松川 昭博

    日本病理学会会誌   105 ( 1 )   400 - 400   2016.4

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  • 濾胞性リンパ腫の経過中にT細胞性リンパ腫を合併した2症例

    藤澤 真義, 和仁 洋治, 伏見 聡一郎, 佐藤 康晴, 山鳥 一郎, 松川 昭博

    日本病理学会会誌   105 ( 1 )   560 - 560   2016.4

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  • Tracheal stenosis caused by unnoticed foreign bodies Reviewed

    Yuya Ogawara, Tomoyasu Tachibana, Yorihisa Orita, Kaori Uchino, Yoji Wani, Itaru Nagahiro, Yuko Matsuyama, Iku Abe, Masayoshi Fujisawa, Kazunori Nishizaki

    Acta Medica Okayama   68 ( 4 )   249 - 252   2014.8

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    We describe an extremely rare case of tracheal stenosis caused by unnoticed microscopic fiber-like foreign bodies. A 66-year-old woman complained of dyspnea with inspiratory stridor. Magnifying electroendoscopy and computed tomography revealed stenosis involving the entire circumference of the tracheal lumen. Tracheotomy and biopsy were performed. Histologically, the lesion showed chronic inflammation with a deposition of fiber-like foreign bodies. The patient had no history of trauma or inhalation injury, but had undergone intratracheal intubation on 4 occasions. The lesion was incised using semiconductor laser photoresection, and the postoperative course was good. To the best of our knowledge, this represents the first report in the English literature of tracheal stenosis caused by unnoticed foreign bodies. The origin of these fiber-like foreign bodies remains unclear but might be related to chronic inflammation resulting from intratracheal intubations. © 2014 by Okayama University Medical School.

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  • Mucocele in the middle ear Reviewed

    Tomoyasu Tachibana, Yorihisa Orita, Masayoshi Fujisawa, Kazunori Nishizaki

    Otology and Neurotology   35 ( 2 )   92 - 94   2014.2

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    DOI: 10.1097/MAO.0b013e3182a361cd

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  • Factors that make it difficult to diagnose cervical tuberculous lymphadenitis

    Tomoyasu Tachibana, Yorihisa Orita, Masayoshi Fujisawa, Michihiro Nakada, Yuya Ogawara, Yuko Matsuyama, Iku Abe, Yasuharu Sato, Koichi Uesaka, Kazunori Nishizaki

    Journal of Infection and Chemotherapy   19 ( 6 )   1015 - 1020   2013.12

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    Cervical tuberculous lymphadenitis is mainly diagnosed by analyzing tissue samples obtained by fine-needle aspiration (FNA). However, some cases remain diagnostic challenges even after polymerase chain reaction analysis of FNA specimens. To delineate differences between cases that are relatively easy to diagnose and those for which diagnosis is difficult, 22 patients with cervical tuberculous lymphadenitis were studied retrospectively. FNA tissues were used to diagnose 14 cases (group A), whereas excisional biopsy was required for accurate diagnosis of 8 cases (group B). These two groups were compared with regard to results of blood examinations, ultrasound appearance, and various other procedures required to reach the final diagnosis. The results indicated that diagnosis of cervical tuberculous lymphadenitis was more difficult for patients with lower white blood cell counts, lower serum C-reactive protein levels, and absence of lymph node fusion or abscess formation on ultrasonography. The possibility of tuberculosis as a cause of cervical lymphadenopathy should always be considered, even when the presenting symptoms are not typical of this disease. © 2013 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases.

    DOI: 10.1007/s10156-013-0615-8

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  • Oxaliplatin-induced liver injury mimicking metastatic tumor on images: a case report(共著) Reviewed

    Japanese journal of clinical oncology   43 ( 10 )   1034 - 1038   2013.10

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    DOI: 10.1093/jjco/hyt113

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  • 1型自己免疫性膵炎におけるマクロファージの分布の検討

    内野 かおり, 能登原 憲司, 藤澤 真義, 和仁 洋治, 松川 昭博

    日本病理学会会誌   102 ( 1 )   439 - 439   2013.4

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  • Papillary thyroid carcinoma arising from a median ectopic thyroid with no thyroglossal duct remnant

    Tomoyasu Tachibana, Yorihisa Orita, Masayoshi Fujisawa, Yuya Ogawara

    Acta Medica Okayama   67 ( 1 )   61 - 64   2013

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    Thyroid carcinomas arising from ectopic thyroid tissue are uncommon; most of them arise from thyroid tissuein thyroglossal cysts. A rare case of a 66-year-old woman with papillary thyroid carcinoma arising from median ectopic thyroid tissue lacking a thyroglossal duct remnant is reported. The tumor was resected by Sistrunks procedure, and the patient's postoperative course was good. © 2013 by Okayama University Medical School.

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  • 膵癌におけるFNA検体と切除検体とのPD-L1発現の検討

    松本和幸, 高木章乃夫, 大原利章, 藤澤真義, 高原政宏, 加藤博也, 吉田龍一, 楳田祐三, 八木孝仁, 松川昭博, 岡田裕之

    日本消化器病学会雑誌(Web)   116   2019

  • Spred2欠損は内臓脂肪織炎,インスリン抵抗性を増悪させる

    大倉隆宏, 丸谷梨栄, 丸谷梨栄, 吉村禎造, 藤澤真義, 大原利章, 松川昭博

    日本病理学会会誌   107 ( 1 )   2018

  • 膀胱腫瘍におけるRas-ERK経路とその制御因子Spred-2の解析

    小田晋輔, 藤澤真義, 吉村禎造, 大原利章, 河原明奈, 山口隆廣, 太田陽子, 松川昭博

    日本病理学会会誌   106 ( 1 )   2017

  • 臨床病態に近い不均一性とがん幹細胞を備えた新規腫瘍モデルの開発

    大原利章, 友野靖子, 友野靖子, 吉村禎造, 藤澤真義, 松川昭博

    日本病理学会会誌   105 ( 1 )   2016

  • 膀胱腫瘍におけるRas-Raf-ERK経路とその制御因子Spred-2の解析

    小田晋輔, 藤澤真義, 吉村禎造, 大原利章, 河原明奈, 山口隆廣, 太田陽子, 松川昭博

    日本病理学会会誌   105 ( 1 )   2016

 

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  • Research Projects and Practicals: Pathology and Experimental Medicine I (2020academic year) special  - その他

  • Lecture and Research Projects: Pathology and Experimental Medicine I (2020academic year) special  - その他

  • Research Projects and Practicals: Pathology and Experimental Medicine II (2020academic year) special  - その他

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