Faculty Profiles - TAKESHITA Yohei

Papers - TAKESHITA Yohei

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Clinical anatomy of the submental vein. International journal

Soichiro Ishii, Norio Kitagawa, Shogo Kikuta, Eiji Iwata, Saw Kalyar Htike, Keiko Fukino, Yohei Takeshita, Kenji Mitsudo, R Shane Tubbs, Joe Iwanaga

Surgical and radiologic anatomy : SRA 47 ( 1 ) 127 - 127 2025.4

Language：English Publishing type：Research paper (scientific journal)

This review provides a comprehensive overview of the anatomy of the submental vein, synthesizing recent findings on its development, anatomical features, course, and clinical significance. Additionally, it introduces the mylohyoid triangle, a new anatomical landmark where the submental vein, submental artery, and the nerve to the mylohyoid muscle run in parallel. As an essential structure in head and neck reconstructive surgery, the submental vein exhibits considerable anatomical variability, primarily due to its complex developmental process. This review highlights the importance of understanding the anatomy of the submental vein and performing thorough preoperative evaluations to enhance surgical success.

DOI： 10.1007/s00276-025-03636-6

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A case of a large venous ring around the mandibular condyle. International journal

Keitaro Nishi, Tatsuo Okui, Yohei Takeshita, Jingo Kusukawa, R Shane Tubbs, Joe Iwanaga

Surgical and radiologic anatomy : SRA 47 ( 1 ) 95 - 95 2025.3

Language：English Publishing type：Research paper (scientific journal)

Anatomical details regarding venous drainage of the head and neck are an important matter for surgeons to avoid unnecessary complications such as hemorrhage. This report describes a case of the large venous ring around the mandibular condyle found in the cadaver. The left maxillofacial region of a latex-injected embalmed male cadaver (82 years of age at death) was dissected. The large two maxillary veins ran lateral to the capsule and superior to the mandibular notch and coursed posteroinferiorly to merge, and one trunk was formed at the posterior border of the ramus. It then received the superficial temporal vein superiorly to form the retromandibular vein (RMV). In addition, three maxillary veins were drained from the pterygoid venous plexus (PVP), medial to the ramus, one maxillary vein drained from the PVP into the RMV trunk, while two maxillary veins drained from the PVP into the anterior division of the RMV. All five large veins lateral and medial to the condyle drained from the PVP into the RMV. The knowledge of such an anatomical variation might prevent intraoperative bleeding in the temporomandibular joint region.

DOI： 10.1007/s00276-025-03602-2

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Evidence-Based Anatomical Terminology in Dentistry Developed by a Consortium of Experts. International journal

Joe Iwanaga, Sergey L Kabak, Puhan He, Yusuke Hamada, Shogo Kikuta, Yohei Takeshita, Rarinthorn Samrid, Thewarid Berkban, Norio Kitagawa, Junichiro Wada, Taku Toriumi, Yuki Matsushita, Soichiro Ibaragi, Mi-Sun Hur, Hee-Jin Kim

Clinical anatomy (New York, N.Y.) 2025.2

Language：English Publishing type：Research paper (scientific journal)

This article aimed to develop evidence-based anatomical terminology in dentistry agreed upon by experts in multiple fields and ultimately to bridge anatomy and clinical dentistry. A comprehensive list of dental anatomical terminology was detailed in table format, and specific terms of interest were highlighted with their respective literature review. The presence of teeth is a unique feature of the oral cavity where dental professionals work. Dentistry is a highly specialized field focusing on preserving the health of dentition and its supporting and surrounding structures. Thus, "teeth" and "mouth" related anatomical terms must be very specialized for dentistry. Many of the terms highlighted were clinical dental or alveolar-related terms that were not clearly established in the general anatomical terminology. The authors hope the evidence-based anatomical terminology in dentistry developed by a consortium of experts will be generally accepted worldwide and ultimately bridge the fields of anatomy and clinical dentistry.

DOI： 10.1002/ca.24260

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Evaluation of CT Findings in Squamous and Non-Squamous Cell Carcinomas of the Maxillary Sinus

Yuka Asaumi, Mamiko Fujikura, Miki Hisatomi, Wlla E. Al-Hammad, Yohei Takeshita, Shunsuke Okada, Toshiyuki Kawazu, Yoshinobu Yanagi, Junichi Asaumi

Journal of Hard Tissue Biology 34 ( 1 ) 35 - 40 2025

Correction: Radiological assessment of the dissection area in supraomohyoid neck dissection. Reviewed International journal

Yohei Takeshita, Joe Iwanaga, Yoshio Ohyama, Soichiro Ibaragi, Yuki Matsushita, R Shane Tubbs, Norio Kitagawa, Toshiyuki Kawazu, Miki Hisatomi, Shunsuke Okada, Mamiko Fujikura, Junichi Asaumi

Surgical and radiologic anatomy : SRA 46 ( 12 ) 1993 - 1994 2024.12

Anatomical relationship between maxillary posterior teeth and the maxillary sinus in an Indonesian population: a CT scan study. Reviewed International journal

Erli Sarilita, Rizky Maulana Muhammad, Harry Galuh Nugraha, Nani Murniati, Harmas Yazid Yusuf, Yohei Takeshita, Junichi Asaumi

BMC oral health 24 ( 1 ) 1014 - 1014 2024.8

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The anatomical proximity between the root apex of the maxillary posterior teeth and the maxillary sinus can lead to complications, including odontogenic maxillary sinusitis. While several studies have investigated similar variables in different populations, there is limited research on the Indonesian population. This study aimed to describe the anatomical position of the maxillary posterior teeth in relation to the floor of the maxillary sinus using CT scans. METHODS: A total of 122 patients (432 maxillary premolars and 1,282 maxillary molars) underwent CT scans to evaluate 1,711 roots. The vertical relationship between the root apex of the maxillary posterior teeth and the maxillary sinus was classified into three types: IS (inside sinus), CO (sinus contact), and OS (outside sinus). RESULTS: The IS type was predominantly found in the palatal roots of the first molars, accounting for 20% of the total roots in this type. The CO type was most frequently observed in the mesiobuccal roots of the second molars, representing 18% of the total roots in this type. The OS type was most commonly found in the first premolar, comprising 20% of the total roots in this type. CONCLUSIONS: The palatal roots of the first molars exhibited the highest frequency of proximity to the maxillary sinus. CT scans can effectively assess the relationship between the root apex of the posterior teeth and the maxillary sinus. CLINICAL RELEVANCE: Clinicians should consider this information comprehensively when planning treatments for maxillary molars.

DOI： 10.1186/s12903-024-04783-9

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Lingual nerve revisited-A comprehensive review Part II: Surgery and radiology. Reviewed International journal

Kisho Ono, Takashi Nishioka, Kyoichi Obata, Yohei Takeshita, Chista Irani, Yuki Kunisada, Norie Yoshioka, Soichiro Ibaragi, R Shane Tubbs, Joe Iwanaga

Clinical anatomy (New York, N.Y.) 2024.8

Language：English Publishing type：Research paper (scientific journal)

The lingual nerve (LN) is a branch of the mandibular division of the fifth cranial nerve, the trigeminal nerve, arising in the infratemporal fossa. It provides sensory fibers to the mucous membranes of the floor of the mouth, the lingual gingiva, and the anterior two-thirds of the tongue. Although the LN should rarely be encountered during routine and basic oral surgical procedures in daily dental practice, its anatomical location occasionally poses the risk of iatrogenic injury. The purpose of this section is to consider this potential LN injury risk and to educate readers about the anatomy of this nerve and how to treat it.

DOI： 10.1002/ca.24211

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Central dentinogenic ghost cell tumor of the maxilla: a case report with new imaging findings and review of the literature Reviewed

Suzuka Yoshida, Yohei Takeshita, Toshiyuki Kawazu, Miki Hisatomi, Shunsuke Okada, Mamiko Fujikura, Kyoichi Obata, Kiyofumi Takabatake, Saori Yoshida, Junichi Asaumi

Oral Radiology 2024.7

Authorship：Corresponding author Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

A dentinogenic ghost cell tumor (DGCT) is a rare benign odontogenic tumor that commonly shows characteristics of solid proliferation and has a relatively high risk of recurrence after surgical treatment. We herein report a case of a central DGCT that occurred in the maxilla and resulted in bone expansion. This study highlights new imaging findings (particularly magnetic resonance imaging) along with histopathological observations. In addition, we conducted a review of the existing literature on this rare tumor. A 37-year-old man developed swelling around the right cheek. A benign odontogenic tumor such as ameloblastoma was suspected based on the imaging examination findings (including bone expansion and the internal characteristics of the tumor) on panoramic imaging, computed tomography, and magnetic resonance imaging. The lesion was surgically excised from the right maxilla. Postoperative histopathological examination led to a definitive diagnosis of central DGCT. The tumor comprised epithelial neoplastic islands, resembling ameloblastoma, inside tight fibroconnective tissue; masses of ghost cells and formation of dentin were also observed. We had suspected that the minute high-density region around the molars on the imaging examinations represented alveolar bone change; however, it represented dentin formation. This led to difficulty diagnosing the lesion. Although DGCT may present characteristic findings on imaging examinations, its occurrence is infrequent, and in some cases, the findings may include the presence or absence of an impacted tooth without obvious calcification. The present case suggests that we should consider the possibility of an odontogenic tumor with calcification when high-density structures are observed inside the lesion.

DOI： 10.1007/s11282-024-00764-4

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Other Link： https://link.springer.com/article/10.1007/s11282-024-00764-4/fulltext.html

Efficacy of Cisplatin–CXCR4 Antagonist Combination Therapy in Oral Cancer Reviewed

Saori Yoshida, Hotaka Kawai, Yamin Soe, Htoo Shwe Eain, Sho Sanou, Kiyofumi Takabatake, Yohei Takeshita, Miki Hisatomi, Hitoshi Nagatsuka, Junichi Asaumi, Yoshinobu Yanagi

Cancers 16 ( 13 ) 2326 - 2326 2024.6

Publishing type：Research paper (scientific journal) Publisher：MDPI AG

Cisplatin is a platinum-based compound that is widely used for treating inoperable oral squamous cell carcinoma (OSCC) in Japan; however, resistance to cisplatin presents a challenge and innovative approaches are required. We aimed to investigate the therapeutic potential of targeting the chemokine receptor CXCR4, which is involved in angiogenesis and tumor progression, using the CXCR4 inhibitor AMD3100, in combination with cisplatin. AMD3100 induced necrosis and bleeding in OSCC xenografts by inhibiting angiogenesis. We investigated the combined ability of AMD3100 plus cisplatin to enhance the antitumor effect in cisplatin-resistant OSCC. An MTS assay identified HSC-2 cells as cisplatin-resistant cells in vitro. Mice treated with the cisplatin-AMD combination exhibited the most significant reduction in tumor volume, accompanied by extensive hemorrhage and necrosis. Histological examination indicated thin and short tumor vessels in the AMD and cisplatin–AMD groups. These results indicated that cisplatin and AMD3100 had synergistic antitumor effects, highlighting their potential for vascular therapy of refractory OSCC. Antitumor vascular therapy using cisplatin combined with a CXCR4 inhibitor provides a novel strategy for addressing cisplatin-resistant OSCC.

DOI： 10.3390/cancers16132326

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Anatomy of the Buccal Space: Surgical and Radiological Perspectives. Reviewed International journal

Chung Yoh Kim, Yohei Takeshita, Takuma Kugimoto, Hiroyuki Harada, Jin Seo Park, R Shane Tubbs, Joe Iwanaga

The Journal of craniofacial surgery 2024.6

Language：English Publishing type：Research paper (scientific journal)

Among the anatomical spaces in the head and neck area, the buccal space has often been studied in dental/oral surgery and cosmetic surgery because it contains the facial vessels, mandibular and facial nerves, and adipose tissue called the buccal fat pad. In addition, as the space can communicate with other spaces, it can be significant in infections. Although the anatomy of the buccal space has been reported in several studies, there have been discrepancies concerning its boundaries, and its communications have often been overlooked. The aim of this review is to examine the anatomy of buccal space including its boundaries, contents, continuity with adjacent spaces, and clinical significance. A literature review was performed on Google Scholar and PubMed. The literature has depicted the anterior, medial, and lateral boundaries more or less consistently, but descriptions of the posterior, superior, and inferior borders are controversial. The buccal space includes the facial arteries, veins, facial nerves, parotid duct, and lymph nodes, which can be described differently depending on definitions and the extent of the space. As it communicates with other anatomical spaces including the masticatory space, it can be a reservoir and a channel for infections and tumors. Buccal fat pads have various clinical applications, from a candidate for flap reconstruction to a target for removal for cosmetic purposes. This review will help understand the anatomy of the buccal space including its boundaries, residing structures, and communication with other spaces from surgical and radiological perspectives.

DOI： 10.1097/SCS.0000000000010411

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Imaging characteristics of incidentally detected cosmetic surgery-derived foreign bodies on CT images in the maxillofacial region Reviewed

Miki Hisatomi, Yohei Takeshita, Yoshinobu Yanagi, Shunsuke Okada, Mamiko Fujikura, Suzuka Yoshida, Toshiyuki Kawazu, Junichi Asaumi

Oral Radiology 2024.4

Preliminary Study of Dental Caries Detection by Deep Neural Network Applying Domain-Specific Transfer Learning Reviewed

Toshiyuki Kawazu, Yohei Takeshita, Mamiko Fujikura, Shunsuke Okada, Miki Hisatomi, Junichi Asaumi

Journal of Medical and Biological Engineering 2024.2

Radiological assessment of the dissection area in supraomohyoid neck dissection Reviewed

Yohei Takeshita, Joe Iwanaga, Yoshio Ohyama, Soichiro Ibaragi, Yuki Matsushita, R. Shane Tubbs, Norio Kitagawa, Toshiyuki Kawazu, Miki Hisatomi, Shunsuke Okada, Mamiko Fujikura, Junichi Asaumi

Surgical and Radiologic Anatomy 2024

Authorship：Lead author,　Corresponding author Publishing type：Research paper (scientific journal)

Purpose: The current supraomohyoid neck dissection (SOHND) is performed above the omohyoid muscle to dissect levels I, II, and III in the levels of cervical lymph nodes. However, the anatomical boundary between levels III and IV is the inferior border of the cricoid cartilage. We investigated the anatomical relationship between the omohyoid muscle and cricoid cartilage using contrast-enhanced CT (CE-CT) images to assess the validity of the current SOHND. Methods: CE-CT images of the head and neck regions in patients were reviewed. The patients were divided into two groups: “malignant tumors” and “others”. The vertebral levels corresponding to the positions of anatomical structures such as the intersection of the omohyoid muscle and internal jugular vein (OM-IJ), and the inferior border of the cricoid cartilage (CC), were recorded. Results: The OM-IJ was located around the seventh cervical to the first thoracic vertebra. There was a significant difference between the malignant tumor and others groups in females (p = 0.036). The CC was located around the sixth to seventh cervical vertebrae. There was a significant sex difference in each group (malignant tumor: p < 0.0001; others: p = 0.008). Both sexes tended to have lower OM-IJ than CC, and females had significantly lower OM-IJ than males. Conclusion: This study provides clear anatomical evidence showing the difference between the SOHND dissection area and levels I, II, and III. It could be considered that in most cases SOHND invades level IV, not just levels I, II, and III, especially in female patients.

DOI： 10.1007/s00276-024-03453-3

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Mylohyoid Muscle: Current Understanding for Clinical Management Part II: Clinical Anatomy, Radiology, and Surgical/Clinical Relevance. Reviewed International journal

Kyoichi Obata, Norio Kitagawa, Kisho Ono, Hideka Kanemoto, Keiko Fukino, Yohei Takeshita, Soichiro Ibaragi, R Shane Tubbs, Joe Iwanaga

The Journal of craniofacial surgery 2023.11

Language：English Publishing type：Research paper (scientific journal)

The mylohyoid is one of the suprahyoid muscles along with the geniohyoid, digastric, and stylohyoid muscles that lies between the anterior belly of the digastric muscle inferiorly and the geniohyoid superiorly. In Part II, the radiology and clinical/surgical importance of the mylohyoid muscle will be discussed.

DOI： 10.1097/SCS.0000000000009797

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Mylohyoid Muscle: Current Understanding for Clinical Management-Part I: Anatomy and Embryology. Reviewed International journal

Kyoichi Obata, Norio Kitagawa, Kisho Ono, Hideka Kanemoto, Keiko Fukino, Yohei Takeshita, Soichiro Ibaragi, Richard S Tubbs, Joe Iwanaga

The Journal of craniofacial surgery 2023.11

Language：English Publishing type：Research paper (scientific journal)

The mylohyoid is one of the suprahyoid muscles, along with the geniohyoid, digastric, and stylohyoid muscles. It lies between the anterior belly of the digastric muscle inferiorly and the geniohyoid superiorly. In Part I, the anatomy and embryology of the mylohyoid muscle will be reviewed in preparation for the clinical discussion in Part II.

DOI： 10.1097/SCS.0000000000009812

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An imaging‑based diagnostic approach to vascular anomalies of the oral and maxillofacial region Reviewed

Wlla Al‑Hammad, Mamiko Fujikura, Miki Hisatomi, Shunsuke Okada, Luciana Munhoz, Toshiyuki Kawazu, Yohei Takeshita, Mariko Fujita, Yoshinobu Yanagi, Jun-Ichi Asaumi

Oncology Letters 26 ( 3 ) 2023.7

分化度の異なる口腔扁平上皮癌におけるシスプラチンとCXCR4阻害剤併用の効果

吉田沙織, 河合穂高, 竹下洋平, 岡田俊輔, 藤倉満美子, 久富美紀, 河津俊幸, 長塚仁, 浅海淳一, 柳文修

日本口腔内科学会雑誌 28 ( 2 ) 106 - 106 2022.12

Collision tumor of small cell carcinoma and squamous cell carcinoma of the maxillary sinus: Case report. Reviewed International journal

Irfan Sugianto, Yoshinobu Yanagi, Miki Hisatomi, Shunsuke Okada, Yohei Takeshita, Babatunde Olamide Bamgbose, Junichi Asaumi

Molecular and clinical oncology 16 ( 5 ) 96 - 96 2022.5

Language：English

A collision tumor refers to the coexistence of two diagnostically distinct tumors in a common anatomic space. Collision tumors are rare in the oral and maxillofacial region. The present study reported on the case of an 82-year-old female with a collision tumor in the maxillary sinus consisting of small cell carcinoma (SmCC) and squamous cell carcinoma (SCC). Computed tomography (CT) imaging revealed a mass in the right maxillary sinus. The lesion exhibited heterogeneous low signal intensity (SI) on T1-weighted imaging (T1WI), high SI on short T1 inversion recovery and heterogeneous solid enhancement on contrast-enhanced T1WI. The histopathology result of a biopsy specimen confirmed SmCC. After the patient received a course of chemoradiotherapy, follow-up CT revealed a residual tumor. In a second surgery, a remaining tumor and histopathology revealed SCC with no evidence of SmCC. The final diagnosis was a collision tumor made up of SCC and SmCC.

DOI： 10.3892/mco.2022.2529

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Ultrasound procedure for the diagnosis of mass lesions in the oral region. Reviewed

Yohei Takeshita, Toshiyuki Kawazu, Miki Hisatomi, Shunsuke Okada, Mamiko Fujikura, Saori Yoshida, Yuri Namba, Yudai Shimizu, Yoshinobu Yanagi, Junichi Asaumi

Oral radiology 2022.3

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: To examine the diagnostic usefulness and procedures of ultrasonography (US) for mass lesions in the soft tissue of the oral region. METHODS: This study involved patients with mass lesions (tumorous lesions and cysts) who had undergone US and histopathological examinations from January 2017 to December 2019. The following points were evaluated by two observers using an evaluation scale: vascularity, echo intensity level, boundary, margin shape, distribution of internal echoes, and capsule. The usefulness of each point for differential diagnosis of tumorous lesions and cysts was statistically analyzed. RESULTS: Forty-five mass lesions in the soft tissue of the oral region (33 tumorous lesions and 12 cysts) were analyzed. There were significant differences in four evaluation points between the tumorous lesions and cysts: vascularity, echo intensity level, boundary, and margin shape. Cysts were almost completely excluded diagnostically, especially when vascularity was observed. There were also significant differences in two evaluation points between nonvascular tumorous lesions and cysts: echo intensity level and boundary. CONCLUSIONS: In US examination for mass lesions in the oral region, it was possible to diagnose tumorous lesions and exclude cysts when vascularity was observed. When vascularity was not observed, however, tumorous lesions and cysts could be identified using two evaluation points: echo intensity level and boundary.

DOI： 10.1007/s11282-022-00605-2

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Influence of mesiodens on adjacent teeth and the timing of its safe removal. Reviewed International journal

Majd Barham, Shunsuke Okada, Miki Hisatomi, Abdullah Khasawneh, Nouha Tekiki, Yohei Takeshita, Toshiyuki Kawazu, Mariko Fujita, Yoshinobu Yanagi, Junichi Asaumi

Imaging science in dentistry 52 ( 1 ) 67 - 74 2022.3

Language：English Publishing type：Research paper (scientific journal)

Purpose: To focus on the effects of the presence of mesiodens on adjacent teeth and to investigate the timing of its safe removal. Materials and Methods: Cone-beam computed tomography examinations, obtained at Okayama University Hospital over a three-year period, were inspected. Data were recorded including the number of mesiodens; associated abnormalities; and the relationship with neighboring structures. Depending on multiple factors, the risk of developing complications due to early extraction of a mesiodens was divided into three categories: high, medium, and low risk. Results: A total of 5,958 cone-beam computed tomography exams were obtained, 460 patients aged 3-85 years were diagnosed with a total of 568 mesiodens, 382 (67.3%) of which were discovered in young patients (age <10 years), and 333 (87.2%) of these were associated with abnormalities. Regarding the risk categories, 11 (1.9%) were considered to be in the high-risk, five (0.9%) in the medium-risk and 552 (97.2%) in the low-risk categories. Moreover, eight out of 11 high-risk mesiodens were extracted and no post-operative complications have been seen. Conclusion: As the results showed that no postoperative complications were seen in all the extracted cases of high-risk mesiodens, this indicates the possibility of safe extraction at an early age which could reduce related future complications.

DOI： 10.5624/isd.20210218

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Papers - TAKESHITA Yohei