研究者詳細 - 石川　崇典

論文 - 石川　崇典

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Malocclusion impairs cognitive behavior via AgRP signaling in adolescent mice. 査読国際誌

Junya Kusumoto, Koji Ataka, Haruki Iwai, Yasuhiko Oga, Keita Yamagata, Kanako Marutani, Takanori Ishikawa, Akihiro Asakawa, Shouichi Miyawaki

Frontiers in neuroscience 17 1156523 - 1156523 2023年

記述言語：英語掲載種別：研究論文（学術雑誌）

INTRODUCTION: Occlusal disharmony induced by deteriorating oral health conditions, such as tooth loss and decreased masticatory muscle due to sarcopenia, is one of the causes of cognitive impairment. Chewing is an essential oral function for maintaining cognitive function not only in the elderly but also in young people. Malocclusion is an occlusal disharmony that commonly occurs in children. The connection between a decline in cognitive function and malocclusion in children has been shown with chronic mouth breathing, obstructive sleep apnea syndrome, and thumb/digit sucking habits. However, the mechanism of malocclusion-induced cognitive decline is not fully understood. We recently reported an association between feeding-related neuropeptides and cognitive decline in adolescent mice with activity-based anorexia. The aim of the present study was to assess the effects of malocclusion on cognitive behavior and clarify the connection between cognitive decline and hypothalamic feeding-related neuropeptides in adolescent mice with malocclusion. METHODS: Four-week-old mice were randomly assigned to the sham-operated solid diet-fed (Sham/solid), sham-operated powder diet-fed (Sham/powder), or malocclusion-operated powder diet-fed (Malocclusion/powder) group. We applied composite resin to the mandibular anterior teeth to simulate malocclusion. We evaluated cognitive behavior using a novel object recognition (NOR) test, measured hypothalamic feeding-related neuropeptide mRNA expression levels, and enumerated c-Fos-positive cells in the hypothalamus 1 month after surgery. We also evaluated the effects of central antibody administration on cognitive behavior impairment in the NOR test. RESULTS: The NOR indices were lower and the agouti-related peptide (AgRP) mRNA levels and number of c-Fos-positive cells were higher in the malocclusion/powder group than in the other groups. The c-Fos-positive cells were also AgRP-positive. We observed that the central administration of anti-AgRP antibody significantly increased the NOR indices. DISCUSSION: The present study suggests that elevated cerebral AgRP signaling contributes to malocclusion-induced cognitive decline in adolescents, and the suppression of AgRP signaling can be a new therapeutic target against cognitive decline in occlusal disharmony.

DOI： 10.3389/fnins.2023.1156523

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A novel auxiliary device enhances the miniscrew stability under immediate heavy loading simulating orthopedic treatment. 査読国際誌

Keita Yamagata, Yasuhiko Oga, Sangho Kwon, Aya Maeda-Iino, Takanori Ishikawa, Shouichi Miyawaki

The Angle orthodontist 93 ( 1 ) 71 - 78 2022年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: To evaluate miniscrew stability and perform a histomorphometric analysis of the bone around the miniscrew under a load corresponding to orthopedic force. MATERIALS AND METHODS: Thirty-two miniscrews were implanted into eight rabbit tibias. Auxiliary group rabbits received auxiliary devices with miniscrews (n = 8, 28 days; n = 8, 56 days), and those in the nonauxiliary control group received miniscrews without auxiliary devices (n = 8, 28 days; n = 8, 56 days). Elastics were placed between miniscrews to apply a load of 5 N. Miniscrew stability was evaluated using a Periotest. Bone-to-implant contact (BIC) and spike implantation depth were measured histomorphologically. RESULTS: Periotest values in the auxiliary group were significantly lower than those in the nonauxiliary group at all time periods. There was no significant difference in BIC between the auxiliary and nonauxiliary groups at 28 or 56 days postimplantation. The implantation spike depth in the auxiliary group was significantly greater at 56 days compared to that at 28 days. Newly formed bone was observed around the spike of the auxiliary device at 56 days. CONCLUSIONS: The results suggest that the use of miniscrews in conjunction with auxiliary devices provides stable skeletal anchorage, which may be useful in orthopedic treatments.

DOI： 10.2319/022222-163.1

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Retrotransposons Manipulating Mammalian Skeletal Development in Chondrocytes. 査読国際誌

Satoshi Kubota, Takanori Ishikawa, Kazumi Kawata, Takako Hattori, Takashi Nishida

International journal of molecular sciences 21 ( 5 ) 2020年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

Retrotransposons are genetic elements that copy and paste themselves in the host genome through transcription, reverse-transcription, and integration processes. Along with their proliferation in the genome, retrotransposons inevitably modify host genes around the integration sites, and occasionally create novel genes. Even now, a number of retrotransposons are still actively editing our genomes. As such, their profound role in the evolution of mammalian genomes is obvious; thus, their contribution to mammalian skeletal evolution and development is also unquestionable. In mammals, most of the skeletal parts are formed and grown through a process entitled endochondral ossification, in which chondrocytes play central roles. In this review, current knowledge on the evolutional, physiological, and pathological roles of retrotransposons in mammalian chondrocyte differentiation and cartilage development is summarized. The possible biological impact of these mobile genetic elements in the future is also discussed.

DOI： 10.3390/ijms21051564

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Screening of key candidate genes and pathways for osteocytes involved in the differential response to different types of mechanical stimulation using a bioinformatics analysis 査読

Wang Z, Ishihara Y, Ishikawa T, Hoshijima M, Odagaki N, Hlaing EEH, Kamioka H

J. Bone Miner Metab 37 ( 4 ) 614 - 626 2019年7月

Physiological role of urothelial cancer-associated one long noncoding RNA in human skeletogenic cell differentiation. 査読国際誌

Takanori Ishikawa, Takashi Nishida, Mitsuaki Ono, Takeshi Takarada, Ha Thi Nguyen, Shinnosuke Kurihara, Takayuki Furumatsu, Yurika Murase, Masaharu Takigawa, Toshitaka Oohashi, Hiroshi Kamioka, Satoshi Kubota

Journal of cellular physiology 233 ( 6 ) 4825 - 4840 2018年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

A vast number of long-noncoding RNAs (lncRNA) are found expressed in human cells, which RNAs have been developed along with human evolution. However, the physiological functions of these lncRNAs remain mostly unknown. In the present study, we for the first time uncovered the fact that one of such lncRNAs plays a significant role in the differentiation of chondrocytes and, possibly, of osteoblasts differentiated from mesenchymal stem cells, which cells eventually construct the human skeleton. The urothelial cancer-associated 1 (UCA1) lncRNA is known to be associated with several human malignancies. Firstly, we confirmed that UCA1 was expressed in normal human chondrocytes, as well as in a human chondrocytic cell line; whereas it was not detected in human bone marrow mesenchymal stem cells (hBMSCs). Of note, although UCA1 expression was undetectable in hBMSCs, it was markedly induced along with the differentiation toward chondrocytes, suggesting its critical role in chondrogenesis. Consistent with this finding, silencing of the UCA1 gene significantly repressed the expression of chondrogenic genes in human chondrocytic cells. UCA1 gene silencing and hyper-expression also had a significant impact on the osteoblastic phenotype in a human cell line. Finally, forced expression of UCA1 in a murine chondrocyte precursor, which did not possess a UCA1 gene, overdrove its differentiation into chondrocytes. These results indicate a physiological and important role of this lncRNA in the skeletal development of humans, who require more sustained endochondral ossification and osteogenesis than do smaller vertebrates.

DOI： 10.1002/jcp.26285

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口蓋の歯科矯正用アンカースクリューと小臼歯の片顎抜去を伴う矯正歯科治療により過大なoverjetと顎口腔機能を改善した上顎前突症例査読

福嶋美佳, 國則貴玄, 石川崇典, 原田真利那, 楠元淳也, 大賀泰彦, 宮脇正一

Clinical and Investigative Orthodontics (Japanese Edition) 82 ( 1 ) 14 - 20 2023年5月

記述言語：日本語出版者・発行元：(公社)日本矯正歯科学会

上顎前歯の突出,口唇閉鎖不全および前歯部の咀嚼障害を主訴に来院した初診時年齢16歳5ヵ月の女性にマルチブラケット装置による矯正歯科治療を行い,良好な治療結果を得たので報告する.患者は過大なoverjetを伴う骨格性II級を呈していた.口蓋正中に歯科矯正用アンカースクリューを植立し,上顎両側第一小臼歯を抜去して,前歯の圧下を伴う後方移動を行った.上顎前歯の移動量は大きかったが,歯根吸収はわずかであった.保定開始から2年6ヵ月が経過し,機能的にも良好な咬合が獲得された.(著者抄録)

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上顎歯列弓幅径を維持しながら矯正歯科治療を行った軟口蓋裂を伴うアングルⅠ級叢生症例査読

石川崇典, 前田綾, 中川祥子, 迫口陽子, 宮脇正一

九州矯正歯科学会雑誌 17 ( 1 ) 1 - 6 2021年12月

口腔機能の異常と早期治療の必要性査読

宮脇正一, 古川みなみ, 丸谷佳菜子, 福嶋美佳, 石川崇典, 渡邉温子, 中川祥子, 髙橋広太郎, 大賀泰彦, 前田綾

東京矯正歯科学会雑誌 31 ( 2 ) 140 - 147 2021年

重度の埋伏永久歯を牽引誘導した2症例査読

石川崇典, 星島光博, 川邉紀章, 上岡寛

岡山歯学会雑誌 37 ( 1 ) 9 - 13 2018年6月

歯科矯正用アンカースクリューおよびオクルーザルスプリントを用いて咬合再構築を行った成人開咬症例査読

早野曉, 星島光博, 石川崇典, 上岡寛

中・四国矯正歯科学会雑誌 28 ( 1 ) 95 - 103 2016年

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