研究者詳細 - 中川　晃志

論文 - 中川　晃志

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S状中隔によるmid-ventricular obstructionに対し、ペーシング治療が有効であった一例

中川晃志, 草野研吾, 福家聡一郎, 田中正道, 多田毅, 村上正人, 宮地晃平, 西井伸洋, 永瀬聡, 岡岳文, 大江透

Circulation Journal 72 ( Suppl.II ) 957 - 957 2008年4月

田中正道, 野坂和正, 中川晃志, 福家聡一郎, 西井伸洋, 永瀬聡, 岡岳文, 草野研吾, 大江透, 河野康之, 小松原一正

Circulation Journal 72 ( Suppl.II ) 953 - 953 2008年4月

Atrial fibrillation in patients with Brugada syndrome relationships of gene mutation, electrophysiology, and clinical backgrounds. 国際誌

Kengo F Kusano, Makiko Taniyama, Kazufumi Nakamura, Daiji Miura, Kimikazu Banba, Satoshi Nagase, Hiroshi Morita, Nobuhiro Nishii, Atsuyuki Watanabe, Takeshi Tada, Masato Murakami, Kohei Miyaji, Shigeki Hiramatsu, Koji Nakagawa, Masamichi Tanaka, Aya Miura, Hideo Kimura, Soichiro Fuke, Wakako Sumita, Satoru Sakuragi, Shigemi Urakawa, Jun Iwasaki, Tohru Ohe

Journal of the American College of Cardiology 51 ( 12 ) 1169 - 75 2008年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: The goal of our work was to examine the relationships of atrial fibrillation (AF) with genetic, clinical, and electrophysiological backgrounds in Brugada syndrome (BrS). BACKGROUND: Atrial fibrillation is often observed in patients with BrS and indicates that electrical abnormality might exist in the atrium as well as in the ventricle. SCN5A, a gene encoding the cardiac sodium channel, has been reported to be causally related to BrS. However, little is known about the relationships of atrial arrhythmias with genetic, clinical, and electrophysiological backgrounds of BrS. METHODS: Seventy-three BrS patients (49 +/- 12 years of age, men/women = 72/1) were studied. The existence of SCN5A mutation and clinical variables (syncopal episode, documented ventricular fibrillation [VF], and family history of sudden death) were compared with spontaneous AF episodes. Genetic and clinical variables were also compared with electrophysiologic (EP) parameters: atrial refractory period, interatrial conduction time (CT), repetitive atrial firing, and AF induction by atrial extra-stimulus testing. RESULTS: Spontaneous AF occurred in 10 (13.7%) of the BrS patients and SCN5A mutation was detected in 15 patients. Spontaneous AF was associated with higher incidence of syncopal episodes (60.0% vs. 22.2%, p < 0.03) and documented VF (40.0% vs. 14.3%, p < 0.05). SCN5A mutation was associated with prolonged CT (p < 0.03) and AF induction (p < 0.05) in EP study, but not related to the spontaneous AF episode and other clinical variables. In patients with documented VF, higher incidence of spontaneous AF (30.8% vs. 10.0%, p < 0.05), AF induction (53.8% vs. 20.0%, p < 0.03), and prolonged CT was observed. CONCLUSIONS: Spontaneous AF and VF are closely linked clinically and electrophysiologically in BrS patients. Patients with spontaneous AF have more severe clinical backgrounds in BrS. SCN5A mutation is associated with electrical abnormality but not disease severity.

DOI： 10.1016/j.jacc.2007.10.060

PubMed

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治療抵抗性の原発性肺高血圧症に対しSildenafil併用が著効した成人男性の一例

中川晃志, 田中正道, 多田毅, 永瀬聡, 中村一文, 櫻木悟, 草野研吾, 大江透

Circulation Journal 71 ( Suppl.III ) 975 - 975 2007年10月

孤立性心筋緻密化障害を有する難治性心不全に対し両心室ペーシングが有用であった1例

中川晃志, 福家聡一郎, 西井伸洋, 永瀬聡, 中村一文, 櫻木悟, 草野研吾, 大江透, 飛岡徹

Journal of Arrhythmia 23 ( Suppl. ) 244 - 244 2007年4月

WPW症候群を合併した家族性肥大型心筋症の一例

赤木達, 大田恵子, 中川晃志, 多田毅, 永瀬聡, 中村一文, 桜木悟, 草野研吾, 大江透

Circulation Journal 71 ( Suppl.II ) 858 - 858 2007年4月

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